-- dump date 20140619_064318 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1121448000001 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 1121448000002 Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934 1121448000003 type II secretion system protein D; Region: type_II_gspD; TIGR02517 1121448000004 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1121448000005 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1121448000006 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1121448000007 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 1121448000008 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 1121448000009 Walker A motif; other site 1121448000010 ATP binding site [chemical binding]; other site 1121448000011 Walker B motif; other site 1121448000012 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 1121448000013 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1121448000014 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1121448000015 C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484 1121448000016 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1121448000017 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1121448000018 S-adenosylmethionine binding site [chemical binding]; other site 1121448000019 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 1121448000020 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1121448000021 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1121448000022 active site 1121448000023 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1121448000024 FeS/SAM binding site; other site 1121448000025 Radical SAM superfamily; Region: Radical_SAM; pfam04055 1121448000026 multiple promoter invertase; Provisional; Region: mpi; PRK13413 1121448000027 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1121448000028 catalytic residues [active] 1121448000029 catalytic nucleophile [active] 1121448000030 Presynaptic Site I dimer interface [polypeptide binding]; other site 1121448000031 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1121448000032 Synaptic Flat tetramer interface [polypeptide binding]; other site 1121448000033 Synaptic Site I dimer interface [polypeptide binding]; other site 1121448000034 DNA binding site [nucleotide binding] 1121448000035 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1121448000036 DNA-binding interface [nucleotide binding]; DNA binding site 1121448000037 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 1121448000038 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 1121448000039 Ligand binding site; other site 1121448000040 oligomer interface; other site 1121448000041 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1121448000042 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 1121448000043 KpsF/GutQ family protein; Region: kpsF; TIGR00393 1121448000044 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 1121448000045 putative active site [active] 1121448000046 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 1121448000047 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1121448000048 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1121448000049 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 1121448000050 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1121448000051 NAD(P) binding site [chemical binding]; other site 1121448000052 active site 1121448000053 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1121448000054 S-adenosylmethionine binding site [chemical binding]; other site 1121448000055 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1121448000056 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 1121448000057 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 1121448000058 trimer interface [polypeptide binding]; other site 1121448000059 active site 1121448000060 substrate binding site [chemical binding]; other site 1121448000061 CoA binding site [chemical binding]; other site 1121448000062 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 1121448000063 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1121448000064 active site 1121448000065 dimer interface [polypeptide binding]; other site 1121448000066 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1121448000067 Ligand Binding Site [chemical binding]; other site 1121448000068 Molecular Tunnel; other site 1121448000069 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1121448000070 Methyltransferase FkbM domain; Region: Methyltransf_21; pfam05050 1121448000071 Methyltransferase domain; Region: Methyltransf_24; pfam13578 1121448000072 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 1121448000073 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 1121448000074 Walker A/P-loop; other site 1121448000075 ATP binding site [chemical binding]; other site 1121448000076 Q-loop/lid; other site 1121448000077 ABC transporter signature motif; other site 1121448000078 Walker B; other site 1121448000079 D-loop; other site 1121448000080 H-loop/switch region; other site 1121448000081 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 1121448000082 putative carbohydrate binding site [chemical binding]; other site 1121448000083 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 1121448000084 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1121448000085 hypothetical protein; Region: PHA01623 1121448000086 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1121448000087 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1121448000088 P-loop; other site 1121448000089 Magnesium ion binding site [ion binding]; other site 1121448000090 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1121448000091 Magnesium ion binding site [ion binding]; other site 1121448000092 Replication initiator protein A; Region: RPA; cl17860 1121448000093 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 1121448000094 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3551 1121448000095 Rhamnan synthesis protein F; Region: RgpF; pfam05045 1121448000096 Glycosyl hydrolase family 99-like domain of WbsX-like glycosyltransferases; Region: Glyco_tran_WbsX; cd11579 1121448000097 putative ligand binding site [chemical binding]; other site 1121448000098 putative catalytic site [active] 1121448000099 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1121448000100 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1121448000101 S-adenosylmethionine binding site [chemical binding]; other site 1121448000102 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 1121448000103 trimer interface [polypeptide binding]; other site 1121448000104 active site 1121448000105 substrate binding site [chemical binding]; other site 1121448000106 CoA binding site [chemical binding]; other site 1121448000107 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1121448000108 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3551 1121448000109 GSCFA family; Region: GSCFA; pfam08885 1121448000110 Glycosyl hydrolase family 99-like domain of WbsX-like glycosyltransferases; Region: Glyco_tran_WbsX; cd11579 1121448000111 putative ligand binding site [chemical binding]; other site 1121448000112 putative catalytic site [active] 1121448000113 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1121448000114 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 1121448000115 Probable Catalytic site; other site 1121448000116 metal-binding site 1121448000117 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1121448000118 Radical SAM superfamily; Region: Radical_SAM; pfam04055 1121448000119 FeS/SAM binding site; other site 1121448000120 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 1121448000121 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1121448000122 ATP binding site [chemical binding]; other site 1121448000123 putative Mg++ binding site [ion binding]; other site 1121448000124 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1121448000125 nucleotide binding region [chemical binding]; other site 1121448000126 ATP-binding site [chemical binding]; other site 1121448000127 Cytochrome c; Region: Cytochrom_C; pfam00034 1121448000128 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 1121448000129 heme-binding residues [chemical binding]; other site 1121448000130 dTDP-glucose 4,6 dehydratase; Provisional; Region: PRK10084 1121448000131 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Validated; Region: PRK05537 1121448000132 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1121448000133 active site 1121448000134 nucleotide binding site [chemical binding]; other site 1121448000135 HIGH motif; other site 1121448000136 KMSKS motif; other site 1121448000137 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 1121448000138 ligand-binding site [chemical binding]; other site 1121448000139 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 1121448000140 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 1121448000141 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1121448000142 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1121448000143 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 1121448000144 Probable Catalytic site; other site 1121448000145 metal-binding site 1121448000146 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 1121448000147 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 1121448000148 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsS; COG3562 1121448000149 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1121448000150 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 1121448000151 substrate-cofactor binding pocket; other site 1121448000152 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1121448000153 catalytic residue [active] 1121448000154 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsS; COG3562 1121448000155 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 1121448000156 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1121448000157 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1121448000158 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1121448000159 NAD(P) binding site [chemical binding]; other site 1121448000160 active site 1121448000161 Sulfatase; Region: Sulfatase; cl17466 1121448000162 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 1121448000163 putative Zn2+ binding site [ion binding]; other site 1121448000164 putative DNA binding site [nucleotide binding]; other site 1121448000165 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1121448000166 Sialic acid synthase [Cell envelope biogenesis, outer membrane]; Region: SpsE; COG2089 1121448000167 NeuB family; Region: NeuB; pfam03102 1121448000168 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 1121448000169 NeuB binding interface [polypeptide binding]; other site 1121448000170 putative substrate binding site [chemical binding]; other site 1121448000171 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1121448000172 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1121448000173 MoxR-like ATPases [General function prediction only]; Region: COG0714 1121448000174 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1121448000175 Walker A motif; other site 1121448000176 ATP binding site [chemical binding]; other site 1121448000177 Walker B motif; other site 1121448000178 arginine finger; other site 1121448000179 Putative metallopeptidase domain; Region: DUF2201_N; pfam13203 1121448000180 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1121448000181 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 1121448000182 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 1121448000183 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 1121448000184 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 1121448000185 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 1121448000186 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1121448000187 sequence-specific DNA binding site [nucleotide binding]; other site 1121448000188 salt bridge; other site 1121448000189 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 1121448000190 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 1121448000191 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 1121448000192 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1121448000193 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1121448000194 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1121448000195 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1121448000196 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1121448000197 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1121448000198 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1121448000199 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 1121448000200 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1121448000201 active site 1121448000202 DNA binding site [nucleotide binding] 1121448000203 Int/Topo IB signature motif; other site 1121448000204 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121448000205 active site 1121448000206 phosphorylation site [posttranslational modification] 1121448000207 intermolecular recognition site; other site 1121448000208 dimerization interface [polypeptide binding]; other site 1121448000209 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1121448000210 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1121448000211 metal binding site [ion binding]; metal-binding site 1121448000212 active site 1121448000213 I-site; other site 1121448000214 HDOD domain; Region: HDOD; pfam08668 1121448000215 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; smart00471 1121448000216 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 1121448000217 DNA protecting protein DprA; Region: dprA; TIGR00732 1121448000218 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 1121448000219 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1121448000220 TPR motif; other site 1121448000221 binding surface 1121448000222 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1121448000223 putative binding surface; other site 1121448000224 active site 1121448000225 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1121448000226 putative binding surface; other site 1121448000227 active site 1121448000228 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 1121448000229 putative binding surface; other site 1121448000230 active site 1121448000231 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 1121448000232 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 1121448000233 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121448000234 ATP binding site [chemical binding]; other site 1121448000235 Mg2+ binding site [ion binding]; other site 1121448000236 G-X-G motif; other site 1121448000237 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 1121448000238 Response regulator receiver domain; Region: Response_reg; pfam00072 1121448000239 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121448000240 active site 1121448000241 phosphorylation site [posttranslational modification] 1121448000242 intermolecular recognition site; other site 1121448000243 dimerization interface [polypeptide binding]; other site 1121448000244 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 1121448000245 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1121448000246 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1121448000247 P-loop; other site 1121448000248 Magnesium ion binding site [ion binding]; other site 1121448000249 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1121448000250 Magnesium ion binding site [ion binding]; other site 1121448000251 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1121448000252 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 1121448000253 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 1121448000254 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 1121448000255 Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cl02500 1121448000256 HEAT repeats; Region: HEAT_2; pfam13646 1121448000257 protein binding surface [polypeptide binding]; other site 1121448000258 HEAT repeats; Region: HEAT_2; pfam13646 1121448000259 HEAT repeats; Region: HEAT_2; pfam13646 1121448000260 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 1121448000261 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 1121448000262 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121448000263 active site 1121448000264 phosphorylation site [posttranslational modification] 1121448000265 intermolecular recognition site; other site 1121448000266 dimerization interface [polypeptide binding]; other site 1121448000267 CheB methylesterase; Region: CheB_methylest; pfam01339 1121448000268 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 1121448000269 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 1121448000270 NAD binding site [chemical binding]; other site 1121448000271 homodimer interface [polypeptide binding]; other site 1121448000272 active site 1121448000273 substrate binding site [chemical binding]; other site 1121448000274 Protein of unknown function (DUF3179); Region: DUF3179; pfam11376 1121448000275 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 1121448000276 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1121448000277 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1121448000278 motif II; other site 1121448000279 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 1121448000280 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 1121448000281 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 1121448000282 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 1121448000283 Walker A motif; other site 1121448000284 ATP binding site [chemical binding]; other site 1121448000285 Walker B motif; other site 1121448000286 hypothetical protein; Provisional; Region: PRK09256 1121448000287 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1121448000288 Thermotoga maritima CorA_like subfamily; Region: TmCorA-like_1; cd12828 1121448000289 oligomer interface [polypeptide binding]; other site 1121448000290 metal binding site [ion binding]; metal-binding site 1121448000291 metal binding site [ion binding]; metal-binding site 1121448000292 Cl binding site [ion binding]; other site 1121448000293 aspartate ring; other site 1121448000294 basic sphincter; other site 1121448000295 putative hydrophobic gate; other site 1121448000296 periplasmic entrance; other site 1121448000297 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1121448000298 hydrogenase 4 subunit F; Validated; Region: PRK06458 1121448000299 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1121448000300 NADH dehydrogenase; Region: NADHdh; cl00469 1121448000301 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 1121448000302 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; pfam00329 1121448000303 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 1121448000304 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 1121448000305 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1121448000306 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 1121448000307 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1121448000308 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1121448000309 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1121448000310 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1121448000311 active site 1121448000312 (T/H)XGH motif; other site 1121448000313 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 1121448000314 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1121448000315 S-adenosylmethionine binding site [chemical binding]; other site 1121448000316 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 1121448000317 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1121448000318 Beta-Casp domain; Region: Beta-Casp; smart01027 1121448000319 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1121448000320 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 1121448000321 Protein of unknown function (DUF1847); Region: DUF1847; pfam08901 1121448000322 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1121448000323 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1121448000324 RNA binding surface [nucleotide binding]; other site 1121448000325 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 1121448000326 active site 1121448000327 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 1121448000328 Outer membrane lipoprotein carrier protein LolA; Region: LolA; pfam03548 1121448000329 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 1121448000330 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1121448000331 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1121448000332 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 1121448000333 elongation factor P; Validated; Region: PRK00529 1121448000334 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1121448000335 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1121448000336 RNA binding site [nucleotide binding]; other site 1121448000337 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1121448000338 RNA binding site [nucleotide binding]; other site 1121448000339 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 1121448000340 Dehydroquinase class II; Region: DHquinase_II; pfam01220 1121448000341 trimer interface [polypeptide binding]; other site 1121448000342 active site 1121448000343 dimer interface [polypeptide binding]; other site 1121448000344 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 1121448000345 G1 box; other site 1121448000346 GTP/Mg2+ binding site [chemical binding]; other site 1121448000347 Switch I region; other site 1121448000348 G2 box; other site 1121448000349 G3 box; other site 1121448000350 Switch II region; other site 1121448000351 G4 box; other site 1121448000352 G5 box; other site 1121448000353 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 1121448000354 Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237 1121448000355 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1121448000356 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1121448000357 S-adenosylmethionine binding site [chemical binding]; other site 1121448000358 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 1121448000359 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1121448000360 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1121448000361 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; cl01412 1121448000362 PAS domain; Region: PAS_9; pfam13426 1121448000363 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121448000364 putative active site [active] 1121448000365 heme pocket [chemical binding]; other site 1121448000366 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1121448000367 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1121448000368 metal binding site [ion binding]; metal-binding site 1121448000369 active site 1121448000370 I-site; other site 1121448000371 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 1121448000372 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1121448000373 substrate binding pocket [chemical binding]; other site 1121448000374 membrane-bound complex binding site; other site 1121448000375 hinge residues; other site 1121448000376 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 1121448000377 dTDP-glucose 4,6-dehydratase; Region: dTDP_gluc_dehyt; TIGR01181 1121448000378 NAD binding site [chemical binding]; other site 1121448000379 substrate binding site [chemical binding]; other site 1121448000380 homodimer interface [polypeptide binding]; other site 1121448000381 active site 1121448000382 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 1121448000383 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 1121448000384 NADP binding site [chemical binding]; other site 1121448000385 active site 1121448000386 putative substrate binding site [chemical binding]; other site 1121448000387 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 1121448000388 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1121448000389 Walker A motif; other site 1121448000390 ATP binding site [chemical binding]; other site 1121448000391 Walker B motif; other site 1121448000392 arginine finger; other site 1121448000393 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1121448000394 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 1121448000395 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1121448000396 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1121448000397 putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015 1121448000398 AAA ATPase domain; Region: AAA_16; pfam13191 1121448000399 type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515 1121448000400 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1121448000401 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1121448000402 Pilus assembly protein, PilO; Region: PilO; cl01234 1121448000403 type IV pilus assembly protein PilM; Region: pilM; TIGR01175 1121448000404 N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573 1121448000405 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 1121448000406 putative active site; other site 1121448000407 catalytic triad [active] 1121448000408 putative dimer interface [polypeptide binding]; other site 1121448000409 Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains [Transcription / Signal transduction mechanisms]; Region: FhlA; COG3604 1121448000410 GAF domain; Region: GAF; pfam01590 1121448000411 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1121448000412 Walker A motif; other site 1121448000413 ATP binding site [chemical binding]; other site 1121448000414 Walker B motif; other site 1121448000415 arginine finger; other site 1121448000416 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1121448000417 indolepyruvate oxidoreductase subunit beta; Reviewed; Region: PRK06853 1121448000418 indolepyruvate ferredoxin oxidoreductase, alpha subunit; Region: IOR_alpha; TIGR03336 1121448000419 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 1121448000420 dimer interface [polypeptide binding]; other site 1121448000421 PYR/PP interface [polypeptide binding]; other site 1121448000422 TPP binding site [chemical binding]; other site 1121448000423 substrate binding site [chemical binding]; other site 1121448000424 Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008 1121448000425 TPP-binding site; other site 1121448000426 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 1121448000427 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 1121448000428 putative catalytic cysteine [active] 1121448000429 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1121448000430 nicotinate (nicotinamide) nucleotide adenylyltransferase; Region: TIGR00482 1121448000431 active site 1121448000432 (T/H)XGH motif; other site 1121448000433 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1121448000434 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 1121448000435 Uncharacterized conserved protein [Function unknown]; Region: COG3379 1121448000436 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 1121448000437 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1121448000438 Radical SAM superfamily; Region: Radical_SAM; pfam04055 1121448000439 FeS/SAM binding site; other site 1121448000440 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 1121448000441 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 1121448000442 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 1121448000443 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1121448000444 putative acyl-acceptor binding pocket; other site 1121448000445 B12 binding domain; Region: B12-binding; pfam02310 1121448000446 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 1121448000447 B12 binding site [chemical binding]; other site 1121448000448 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1121448000449 FeS/SAM binding site; other site 1121448000450 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 1121448000451 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 1121448000452 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1121448000453 FeS/SAM binding site; other site 1121448000454 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 1121448000455 B12 binding site [chemical binding]; other site 1121448000456 Radical SAM superfamily; Region: Radical_SAM; pfam04055 1121448000457 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1121448000458 putative acyl-acceptor binding pocket; other site 1121448000459 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1121448000460 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 1121448000461 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 1121448000462 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 1121448000463 active site 1121448000464 PHP Thumb interface [polypeptide binding]; other site 1121448000465 metal binding site [ion binding]; metal-binding site 1121448000466 Ribosomal protein S11; Region: Ribosomal_S11; cl00332 1121448000467 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1121448000468 generic binding surface I; other site 1121448000469 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 1121448000470 active site 1121448000471 D-tyrosyl-tRNA(Tyr) deacylase; Provisional; Region: PRK05273 1121448000472 putative active site [active] 1121448000473 dimerization interface [polypeptide binding]; other site 1121448000474 putative tRNAtyr binding site [nucleotide binding]; other site 1121448000475 Response regulator receiver domain; Region: Response_reg; pfam00072 1121448000476 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121448000477 active site 1121448000478 phosphorylation site [posttranslational modification] 1121448000479 intermolecular recognition site; other site 1121448000480 dimerization interface [polypeptide binding]; other site 1121448000481 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1121448000482 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1121448000483 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1121448000484 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1121448000485 anti sigma factor interaction site; other site 1121448000486 regulatory phosphorylation site [posttranslational modification]; other site 1121448000487 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1121448000488 anti sigma factor interaction site; other site 1121448000489 regulatory phosphorylation site [posttranslational modification]; other site 1121448000490 Protein of unknown function (DUF342); Region: DUF342; pfam03961 1121448000491 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 1121448000492 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 1121448000493 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 1121448000494 flagellar motor protein MotS; Reviewed; Region: PRK06925 1121448000495 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1121448000496 ligand binding site [chemical binding]; other site 1121448000497 DUF based on E. rectale Gene description (DUF3880); Region: DUF3880; pfam12996 1121448000498 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 1121448000499 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1121448000500 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1121448000501 putative active site [active] 1121448000502 Flagellar hook capping protein [Cell motility and secretion]; Region: FlgD; COG1843 1121448000503 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 1121448000504 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 1121448000505 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 1121448000506 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1121448000507 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 1121448000508 Flagellar hook protein FlgE [Cell motility and secretion]; Region: FlgE; COG1749 1121448000509 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1121448000510 flagellin; Provisional; Region: PRK12804 1121448000511 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1121448000512 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1121448000513 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 1121448000514 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1121448000515 dimerization interface [polypeptide binding]; other site 1121448000516 active site 1121448000517 metal binding site [ion binding]; metal-binding site 1121448000518 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1121448000519 dsRNA binding site [nucleotide binding]; other site 1121448000520 BioD-like N-terminal domain of phosphotransacetylase [General function prediction only]; Region: Pta; COG0857 1121448000521 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1121448000522 DRTGG domain; Region: DRTGG; pfam07085 1121448000523 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 1121448000524 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1121448000525 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1121448000526 dimer interface [polypeptide binding]; other site 1121448000527 putative CheW interface [polypeptide binding]; other site 1121448000528 Heme NO binding; Region: HNOB; pfam07700 1121448000529 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1121448000530 S-adenosylmethionine binding site [chemical binding]; other site 1121448000531 Putative rRNA methylase; Region: rRNA_methylase; pfam06962 1121448000532 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 1121448000533 substrate binding pocket [chemical binding]; other site 1121448000534 membrane-bound complex binding site; other site 1121448000535 EamA-like transporter family; Region: EamA; pfam00892 1121448000536 EamA-like transporter family; Region: EamA; pfam00892 1121448000537 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1121448000538 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1121448000539 DNA-binding site [nucleotide binding]; DNA binding site 1121448000540 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1121448000541 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1121448000542 homodimer interface [polypeptide binding]; other site 1121448000543 catalytic residue [active] 1121448000544 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 1121448000545 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 1121448000546 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 1121448000547 Walker A motif; other site 1121448000548 ATP binding site [chemical binding]; other site 1121448000549 Walker B motif; other site 1121448000550 Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434 1121448000551 EAL domain; Region: EAL; pfam00563 1121448000552 Membrane transport protein; Region: Mem_trans; cl09117 1121448000553 PAS domain S-box; Region: sensory_box; TIGR00229 1121448000554 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121448000555 putative active site [active] 1121448000556 heme pocket [chemical binding]; other site 1121448000557 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1121448000558 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121448000559 putative active site [active] 1121448000560 heme pocket [chemical binding]; other site 1121448000561 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1121448000562 dimer interface [polypeptide binding]; other site 1121448000563 phosphorylation site [posttranslational modification] 1121448000564 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121448000565 ATP binding site [chemical binding]; other site 1121448000566 Mg2+ binding site [ion binding]; other site 1121448000567 G-X-G motif; other site 1121448000568 HD domain; Region: HD_3; pfam13023 1121448000569 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 1121448000570 heterotetramer interface [polypeptide binding]; other site 1121448000571 active site pocket [active] 1121448000572 cleavage site 1121448000573 Predicted dehydrogenase [General function prediction only]; Region: COG0579 1121448000574 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1121448000575 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1121448000576 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1121448000577 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1121448000578 S-adenosylmethionine binding site [chemical binding]; other site 1121448000579 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 1121448000580 HAMP domain; Region: HAMP; pfam00672 1121448000581 dimerization interface [polypeptide binding]; other site 1121448000582 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1121448000583 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121448000584 putative active site [active] 1121448000585 heme pocket [chemical binding]; other site 1121448000586 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1121448000587 dimer interface [polypeptide binding]; other site 1121448000588 phosphorylation site [posttranslational modification] 1121448000589 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121448000590 ATP binding site [chemical binding]; other site 1121448000591 G-X-G motif; other site 1121448000592 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 1121448000593 heme-binding residues [chemical binding]; other site 1121448000594 Haemolytic domain; Region: Haemolytic; cl00506 1121448000595 CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870 1121448000596 ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871 1121448000597 phosphoserine phosphatase SerB; Region: serB; TIGR00338 1121448000598 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1121448000599 motif II; other site 1121448000600 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 1121448000601 P22 coat protein - gene protein 5; Region: P22_CoatProtein; pfam11651 1121448000602 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1121448000603 Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; Region: ABCG_EPDR; cd03213 1121448000604 Walker A/P-loop; other site 1121448000605 ATP binding site [chemical binding]; other site 1121448000606 Q-loop/lid; other site 1121448000607 ABC transporter signature motif; other site 1121448000608 Walker B; other site 1121448000609 D-loop; other site 1121448000610 H-loop/switch region; other site 1121448000611 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1121448000612 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1121448000613 PAS domain; Region: PAS_8; pfam13188 1121448000614 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121448000615 putative active site [active] 1121448000616 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1121448000617 heme pocket [chemical binding]; other site 1121448000618 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1121448000619 dimer interface [polypeptide binding]; other site 1121448000620 phosphorylation site [posttranslational modification] 1121448000621 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121448000622 ATP binding site [chemical binding]; other site 1121448000623 Mg2+ binding site [ion binding]; other site 1121448000624 G-X-G motif; other site 1121448000625 Response regulator receiver domain; Region: Response_reg; pfam00072 1121448000626 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121448000627 active site 1121448000628 phosphorylation site [posttranslational modification] 1121448000629 intermolecular recognition site; other site 1121448000630 dimerization interface [polypeptide binding]; other site 1121448000631 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1121448000632 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 1121448000633 Transglutaminase/protease-like homologues; Region: TGc; smart00460 1121448000634 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 1121448000635 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 1121448000636 Uncharacterized conserved protein [Function unknown]; Region: COG2308 1121448000637 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1121448000638 active site 1121448000639 oxyanion hole [active] 1121448000640 PAS domain; Region: PAS_9; pfam13426 1121448000641 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121448000642 putative active site [active] 1121448000643 heme pocket [chemical binding]; other site 1121448000644 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1121448000645 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1121448000646 metal binding site [ion binding]; metal-binding site 1121448000647 active site 1121448000648 I-site; other site 1121448000649 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1121448000650 Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469 1121448000651 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1121448000652 domain interfaces; other site 1121448000653 active site 1121448000654 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 1121448000655 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1121448000656 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1121448000657 HlyD family secretion protein; Region: HlyD_3; pfam13437 1121448000658 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1121448000659 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 1121448000660 intermolecular salt bridges; other site 1121448000661 calcium mediated ligand binding site; other site 1121448000662 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 1121448000663 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 1121448000664 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 1121448000665 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1121448000666 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1121448000667 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1121448000668 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1121448000669 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1121448000670 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1121448000671 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 1121448000672 IMP binding site; other site 1121448000673 dimer interface [polypeptide binding]; other site 1121448000674 interdomain contacts; other site 1121448000675 partial ornithine binding site; other site 1121448000676 Glutamine phosphoribosylpyrophosphate amidotransferase [Nucleotide transport and metabolism]; Region: PurF; COG0034 1121448000677 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1121448000678 active site 1121448000679 tetramer interface [polypeptide binding]; other site 1121448000680 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1121448000681 active site 1121448000682 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 1121448000683 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 1121448000684 Protein of unknown function (DUF456); Region: DUF456; pfam04306 1121448000685 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1121448000686 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 1121448000687 acyl-activating enzyme (AAE) consensus motif; other site 1121448000688 AMP binding site [chemical binding]; other site 1121448000689 active site 1121448000690 CoA binding site [chemical binding]; other site 1121448000691 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 1121448000692 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 1121448000693 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 1121448000694 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 1121448000695 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1121448000696 P loop; other site 1121448000697 GTP binding site [chemical binding]; other site 1121448000698 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 1121448000699 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1121448000700 active site 1121448000701 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cd01635 1121448000702 recombination protein RecR; Reviewed; Region: recR; PRK00076 1121448000703 RecR protein; Region: RecR; pfam02132 1121448000704 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1121448000705 putative active site [active] 1121448000706 putative metal-binding site [ion binding]; other site 1121448000707 tetramer interface [polypeptide binding]; other site 1121448000708 hypothetical protein; Validated; Region: PRK00153 1121448000709 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 1121448000710 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1121448000711 Walker A motif; other site 1121448000712 ATP binding site [chemical binding]; other site 1121448000713 Walker B motif; other site 1121448000714 arginine finger; other site 1121448000715 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 1121448000716 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1121448000717 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1121448000718 homodimer interface [polypeptide binding]; other site 1121448000719 substrate-cofactor binding pocket; other site 1121448000720 catalytic residue [active] 1121448000721 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 1121448000722 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1121448000723 Adenylation domain of proteins similar to ATP-dependent polynucleotide ligases; Region: Adenylation_DNA_ligase_like; cl12015 1121448000724 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1121448000725 EamA-like transporter family; Region: EamA; pfam00892 1121448000726 EamA-like transporter family; Region: EamA; pfam00892 1121448000727 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1121448000728 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 1121448000729 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1121448000730 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1121448000731 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1121448000732 motif II; other site 1121448000733 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1121448000734 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121448000735 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1121448000736 putative active site [active] 1121448000737 heme pocket [chemical binding]; other site 1121448000738 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121448000739 putative active site [active] 1121448000740 heme pocket [chemical binding]; other site 1121448000741 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1121448000742 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1121448000743 dimer interface [polypeptide binding]; other site 1121448000744 phosphorylation site [posttranslational modification] 1121448000745 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121448000746 ATP binding site [chemical binding]; other site 1121448000747 Mg2+ binding site [ion binding]; other site 1121448000748 G-X-G motif; other site 1121448000749 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 1121448000750 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 1121448000751 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 1121448000752 Phage terminase large subunit; Region: Terminase_3; cl12054 1121448000753 DNA-directed RNA polymerase, sigma subunit (sigma70/sigma32) [Transcription]; Region: RpoD; COG0568 1121448000754 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 1121448000755 Cobalt chelatase (CbiK); Region: CbiK; pfam06180 1121448000756 active site 1121448000757 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 1121448000758 active site 1121448000759 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1121448000760 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1121448000761 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1121448000762 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1121448000763 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1121448000764 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1121448000765 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1121448000766 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 1121448000767 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 1121448000768 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1121448000769 EamA-like transporter family; Region: EamA; pfam00892 1121448000770 EamA-like transporter family; Region: EamA; pfam00892 1121448000771 GTP-binding protein YchF; Reviewed; Region: PRK09601 1121448000772 YchF GTPase; Region: YchF; cd01900 1121448000773 G1 box; other site 1121448000774 GTP/Mg2+ binding site [chemical binding]; other site 1121448000775 Switch I region; other site 1121448000776 G2 box; other site 1121448000777 Switch II region; other site 1121448000778 G3 box; other site 1121448000779 G4 box; other site 1121448000780 G5 box; other site 1121448000781 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1121448000782 phosphoglucomutase; Validated; Region: PRK07564 1121448000783 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 1121448000784 active site 1121448000785 substrate binding site [chemical binding]; other site 1121448000786 metal binding site [ion binding]; metal-binding site 1121448000787 Protein of unknown function (DUF497); Region: DUF497; pfam04365 1121448000788 PAS domain S-box; Region: sensory_box; TIGR00229 1121448000789 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121448000790 putative active site [active] 1121448000791 heme pocket [chemical binding]; other site 1121448000792 PAS domain S-box; Region: sensory_box; TIGR00229 1121448000793 PAS domain; Region: PAS; smart00091 1121448000794 putative active site [active] 1121448000795 heme pocket [chemical binding]; other site 1121448000796 PAS domain S-box; Region: sensory_box; TIGR00229 1121448000797 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121448000798 putative active site [active] 1121448000799 heme pocket [chemical binding]; other site 1121448000800 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 1121448000801 Ligand binding site; other site 1121448000802 metal-binding site 1121448000803 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 1121448000804 thiosulfate reductase PhsA; Provisional; Region: PRK15488 1121448000805 The MopB_Thiosulfate-R-like CD contains thiosulfate-, sulfur-, and polysulfide-reductases, and other related proteins. Thiosulfate reductase catalyzes the cleavage of sulfur-sulfur bonds in thiosulfate. Polysulfide reductase is a membrane-bound enzyme...; Region: MopB_Thiosulfate-R-like; cd02755 1121448000806 putative [Fe4-S4] binding site [ion binding]; other site 1121448000807 putative molybdopterin cofactor binding site [chemical binding]; other site 1121448000808 The MopB_CT_Thiosulfate-R-like CD contains thiosulfate-, sulfur-, and polysulfide-reductases, and other related proteins. Thiosulfate reductase catalyzes the cleavage of sulfur-sulfur bonds in thiosulfate. Polysulfide reductase is a membrane-bound enzyme...; Region: MopB_CT_Thiosulfate-R-like; cd02778 1121448000809 putative molybdopterin cofactor binding site; other site 1121448000810 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 1121448000811 NADH dehydrogenase subunit B; Validated; Region: PRK06411 1121448000812 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; pfam00329 1121448000813 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 1121448000814 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 1121448000815 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 1121448000816 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 1121448000817 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 1121448000818 NADH:ubiquinone oxidoreductase subunit 6 (chain J) [Energy production and conversion]; Region: NuoJ; COG0839 1121448000819 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 1121448000820 NADH dehydrogenase subunit 6; Provisional; Region: ND6; MTH00213 1121448000821 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 1121448000822 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK08375 1121448000823 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1121448000824 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12668 1121448000825 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1121448000826 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 1121448000827 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1121448000828 NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; Region: NuoN; COG1007 1121448000829 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1121448000830 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 1121448000831 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1121448000832 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1121448000833 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 1121448000834 putative ADP-binding pocket [chemical binding]; other site 1121448000835 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1121448000836 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 1121448000837 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1121448000838 active site 1121448000839 dimer interface [polypeptide binding]; other site 1121448000840 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1121448000841 Ligand Binding Site [chemical binding]; other site 1121448000842 Molecular Tunnel; other site 1121448000843 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1121448000844 Peptidase family M23; Region: Peptidase_M23; pfam01551 1121448000845 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 1121448000846 Ligand Binding Site [chemical binding]; other site 1121448000847 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 1121448000848 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1121448000849 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1121448000850 Walker A/P-loop; other site 1121448000851 ATP binding site [chemical binding]; other site 1121448000852 Q-loop/lid; other site 1121448000853 ABC transporter signature motif; other site 1121448000854 Walker B; other site 1121448000855 D-loop; other site 1121448000856 H-loop/switch region; other site 1121448000857 gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518 1121448000858 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 1121448000859 Domain of unknown function (DUF4340); Region: DUF4340; pfam14238 1121448000860 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 1121448000861 chaperone protein DnaJ; Provisional; Region: PRK14301 1121448000862 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1121448000863 HSP70 interaction site [polypeptide binding]; other site 1121448000864 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 1121448000865 substrate binding site [polypeptide binding]; other site 1121448000866 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1121448000867 Zn binding sites [ion binding]; other site 1121448000868 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1121448000869 dimer interface [polypeptide binding]; other site 1121448000870 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 1121448000871 trimer interface [polypeptide binding]; other site 1121448000872 dimer interface [polypeptide binding]; other site 1121448000873 putative active site [active] 1121448000874 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 1121448000875 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1121448000876 active site 1121448000877 HIGH motif; other site 1121448000878 nucleotide binding site [chemical binding]; other site 1121448000879 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 1121448000880 KMSKS motif; other site 1121448000881 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 1121448000882 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1121448000883 N-terminal putative catalytic domain of mainly uncharacterized prokaryotic proteins similar to archaeal thermoactive amylopullulanases; glycoside hydrolase family 57 (GH57); Region: GH57N_APU_like_1; cd10797 1121448000884 active site 1121448000885 catalytic site [active] 1121448000886 Domain of unknown function (DUF3536); Region: DUF3536; pfam12055 1121448000887 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1121448000888 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121448000889 putative active site [active] 1121448000890 heme pocket [chemical binding]; other site 1121448000891 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1121448000892 phosphorylation site [posttranslational modification] 1121448000893 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121448000894 ATP binding site [chemical binding]; other site 1121448000895 Mg2+ binding site [ion binding]; other site 1121448000896 G-X-G motif; other site 1121448000897 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1121448000898 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121448000899 active site 1121448000900 phosphorylation site [posttranslational modification] 1121448000901 intermolecular recognition site; other site 1121448000902 dimerization interface [polypeptide binding]; other site 1121448000903 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 1121448000904 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1121448000905 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1121448000906 dimer interface [polypeptide binding]; other site 1121448000907 putative CheW interface [polypeptide binding]; other site 1121448000908 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 1121448000909 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1121448000910 binding surface 1121448000911 TPR motif; other site 1121448000912 Response regulator receiver domain; Region: Response_reg; pfam00072 1121448000913 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121448000914 active site 1121448000915 phosphorylation site [posttranslational modification] 1121448000916 intermolecular recognition site; other site 1121448000917 dimerization interface [polypeptide binding]; other site 1121448000918 The HIRAN protein (HIP116, Rad5p N-terminal) is found in the N-terminal regions of the SWI2/SNF2 proteins typified by HIP116 and Rad5p; Region: HIRAN; smart00910 1121448000919 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542 1121448000920 HSP70 interaction site [polypeptide binding]; other site 1121448000921 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1121448000922 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1121448000923 active site 1121448000924 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1121448000925 LabA_like proteins; Region: LabA_like; cd06167 1121448000926 putative metal binding site [ion binding]; other site 1121448000927 Uncharacterized conserved protein [Function unknown]; Region: COG1432 1121448000928 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 1121448000929 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 1121448000930 phosphate binding site [ion binding]; other site 1121448000931 putative substrate binding pocket [chemical binding]; other site 1121448000932 dimer interface [polypeptide binding]; other site 1121448000933 HprK-related kinase B; Region: HprK_rel_B; TIGR04355 1121448000934 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270 1121448000935 active site 1121448000936 metal-binding site [ion binding] 1121448000937 nucleotide-binding site [chemical binding]; other site 1121448000938 ATP-grasp enzyme, GAK system; Region: grasp_GAK; TIGR04356 1121448000939 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1121448000940 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 1121448000941 PhoU domain; Region: PhoU; pfam01895 1121448000942 PhoU domain; Region: PhoU; pfam01895 1121448000943 Phosphotransferase enzyme family; Region: APH; pfam01636 1121448000944 Ecdysteroid kinase; Region: EcKinase; cl17738 1121448000945 amphi-Trp domain; Region: amphi-Trp; TIGR04354 1121448000946 amphi-Trp domain; Region: amphi-Trp; TIGR04354 1121448000947 XXXCH domain; Region: XXXCH_domain; TIGR04358 1121448000948 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 1121448000949 PhoU domain; Region: PhoU; pfam01895 1121448000950 PhoU domain; Region: PhoU; pfam01895 1121448000951 phosphate transporter ATP-binding protein; Provisional; Region: PRK14242 1121448000952 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1121448000953 Walker A/P-loop; other site 1121448000954 ATP binding site [chemical binding]; other site 1121448000955 Q-loop/lid; other site 1121448000956 ABC transporter signature motif; other site 1121448000957 Walker B; other site 1121448000958 D-loop; other site 1121448000959 H-loop/switch region; other site 1121448000960 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1121448000961 dimerization interface [polypeptide binding]; other site 1121448000962 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1121448000963 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121448000964 putative active site [active] 1121448000965 heme pocket [chemical binding]; other site 1121448000966 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1121448000967 dimer interface [polypeptide binding]; other site 1121448000968 phosphorylation site [posttranslational modification] 1121448000969 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121448000970 ATP binding site [chemical binding]; other site 1121448000971 Mg2+ binding site [ion binding]; other site 1121448000972 G-X-G motif; other site 1121448000973 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1121448000974 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121448000975 active site 1121448000976 phosphorylation site [posttranslational modification] 1121448000977 intermolecular recognition site; other site 1121448000978 dimerization interface [polypeptide binding]; other site 1121448000979 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1121448000980 DNA binding site [nucleotide binding] 1121448000981 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 1121448000982 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 1121448000983 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 1121448000984 Zn binding site [ion binding]; other site 1121448000985 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 1121448000986 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1121448000987 ATP binding site [chemical binding]; other site 1121448000988 putative Mg++ binding site [ion binding]; other site 1121448000989 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1121448000990 nucleotide binding region [chemical binding]; other site 1121448000991 ATP-binding site [chemical binding]; other site 1121448000992 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1121448000993 active site 1121448000994 tetramer interface; other site 1121448000995 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14314 1121448000996 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1121448000997 active site 1121448000998 substrate binding site [chemical binding]; other site 1121448000999 metal binding site [ion binding]; metal-binding site 1121448001000 dihydropteroate synthase; Region: DHPS; TIGR01496 1121448001001 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1121448001002 substrate binding pocket [chemical binding]; other site 1121448001003 dimer interface [polypeptide binding]; other site 1121448001004 inhibitor binding site; inhibition site 1121448001005 FtsH Extracellular; Region: FtsH_ext; pfam06480 1121448001006 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 1121448001007 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1121448001008 Walker A motif; other site 1121448001009 ATP binding site [chemical binding]; other site 1121448001010 Walker B motif; other site 1121448001011 arginine finger; other site 1121448001012 Peptidase family M41; Region: Peptidase_M41; pfam01434 1121448001013 MT-A70; Region: MT-A70; cl01947 1121448001014 Restriction endonuclease BglII; Region: Endonuc-BglII; pfam09195 1121448001015 Right handed beta helix region; Region: Beta_helix; pfam13229 1121448001016 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1121448001017 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121448001018 active site 1121448001019 phosphorylation site [posttranslational modification] 1121448001020 intermolecular recognition site; other site 1121448001021 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1121448001022 DNA binding residues [nucleotide binding] 1121448001023 dimerization interface [polypeptide binding]; other site 1121448001024 Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225 1121448001025 methionine sulfoxide reductase B; Provisional; Region: PRK00222 1121448001026 SelR domain; Region: SelR; pfam01641 1121448001027 PAS fold; Region: PAS_4; pfam08448 1121448001028 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 1121448001029 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1121448001030 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1121448001031 dimer interface [polypeptide binding]; other site 1121448001032 phosphorylation site [posttranslational modification] 1121448001033 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121448001034 ATP binding site [chemical binding]; other site 1121448001035 Mg2+ binding site [ion binding]; other site 1121448001036 G-X-G motif; other site 1121448001037 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 1121448001038 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII; cd09992 1121448001039 active site 1121448001040 Zn binding site [ion binding]; other site 1121448001041 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 1121448001042 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 1121448001043 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 1121448001044 Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; cl00873 1121448001045 DEDDy 3'-5' exonuclease domain of WRN and similar proteins; Region: WRN_exo; cd06141 1121448001046 catalytic site [active] 1121448001047 putative active site [active] 1121448001048 putative substrate binding site [chemical binding]; other site 1121448001049 NAD synthetase; Provisional; Region: PRK13981 1121448001050 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 1121448001051 multimer interface [polypeptide binding]; other site 1121448001052 active site 1121448001053 catalytic triad [active] 1121448001054 protein interface 1 [polypeptide binding]; other site 1121448001055 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1121448001056 homodimer interface [polypeptide binding]; other site 1121448001057 NAD binding pocket [chemical binding]; other site 1121448001058 ATP binding pocket [chemical binding]; other site 1121448001059 Mg binding site [ion binding]; other site 1121448001060 active-site loop [active] 1121448001061 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1121448001062 binding surface 1121448001063 TPR repeat; Region: TPR_11; pfam13414 1121448001064 TPR motif; other site 1121448001065 TPR repeat; Region: TPR_11; pfam13414 1121448001066 Tetratricopeptide repeats; Region: TPR; smart00028 1121448001067 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 1121448001068 DHHW protein; Region: DHHW; pfam14286 1121448001069 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 1121448001070 heme-binding residues [chemical binding]; other site 1121448001071 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1121448001072 Zn2+ binding site [ion binding]; other site 1121448001073 Mg2+ binding site [ion binding]; other site 1121448001074 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 1121448001075 dimer interface [polypeptide binding]; other site 1121448001076 catalytic triad [active] 1121448001077 peroxidatic and resolving cysteines [active] 1121448001078 triosephosphate isomerase; Provisional; Region: PRK14565 1121448001079 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1121448001080 substrate binding site [chemical binding]; other site 1121448001081 dimer interface [polypeptide binding]; other site 1121448001082 catalytic triad [active] 1121448001083 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1121448001084 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1121448001085 isopentenyl-diphosphate delta-isomerase, type 1; Region: IPP_isom_1; TIGR02150 1121448001086 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1121448001087 nudix motif; other site 1121448001088 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1121448001089 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 1121448001090 active site 1121448001091 dimerization interface [polypeptide binding]; other site 1121448001092 rod shape-determining protein MreB; Provisional; Region: PRK13930 1121448001093 MreB and similar proteins; Region: MreB_like; cd10225 1121448001094 nucleotide binding site [chemical binding]; other site 1121448001095 Mg binding site [ion binding]; other site 1121448001096 putative protofilament interaction site [polypeptide binding]; other site 1121448001097 RodZ interaction site [polypeptide binding]; other site 1121448001098 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1121448001099 GAF domain; Region: GAF; pfam01590 1121448001100 GAF domain; Region: GAF_3; pfam13492 1121448001101 GAF domain; Region: GAF_2; pfam13185 1121448001102 cell division protein FtsZ; Validated; Region: PRK09330 1121448001103 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1121448001104 nucleotide binding site [chemical binding]; other site 1121448001105 SulA interaction site; other site 1121448001106 cell division protein FtsA; Region: ftsA; TIGR01174 1121448001107 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1121448001108 nucleotide binding site [chemical binding]; other site 1121448001109 Cell division protein FtsA; Region: FtsA; pfam14450 1121448001110 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 1121448001111 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 1121448001112 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1121448001113 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1121448001114 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1121448001115 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1121448001116 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1121448001117 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 1121448001118 active site 1121448001119 homodimer interface [polypeptide binding]; other site 1121448001120 cell division protein FtsW; Region: ftsW; TIGR02614 1121448001121 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01390 1121448001122 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1121448001123 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1121448001124 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 1121448001125 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1121448001126 Mg++ binding site [ion binding]; other site 1121448001127 putative catalytic motif [active] 1121448001128 putative substrate binding site [chemical binding]; other site 1121448001129 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 1121448001130 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1121448001131 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1121448001132 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 1121448001133 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1121448001134 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1121448001135 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1121448001136 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1121448001137 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1121448001138 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 1121448001139 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 1121448001140 MraW methylase family; Region: Methyltransf_5; cl17771 1121448001141 MraZ protein; Region: MraZ; pfam02381 1121448001142 cell division protein MraZ; Reviewed; Region: PRK00326 1121448001143 MraZ protein; Region: MraZ; pfam02381 1121448001144 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1121448001145 Zn2+ binding site [ion binding]; other site 1121448001146 Mg2+ binding site [ion binding]; other site 1121448001147 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 1121448001148 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 1121448001149 putative dimer interface [polypeptide binding]; other site 1121448001150 active site pocket [active] 1121448001151 putative cataytic base [active] 1121448001152 Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018 1121448001153 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1121448001154 dimer interface [polypeptide binding]; other site 1121448001155 catalytic triad [active] 1121448001156 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1121448001157 catalytic residues [active] 1121448001158 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1121448001159 Ligand Binding Site [chemical binding]; other site 1121448001160 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1121448001161 dimer interface [polypeptide binding]; other site 1121448001162 substrate binding site [chemical binding]; other site 1121448001163 ATP binding site [chemical binding]; other site 1121448001164 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 1121448001165 gamma-glutamyl kinase; Provisional; Region: PRK05429 1121448001166 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1121448001167 nucleotide binding site [chemical binding]; other site 1121448001168 homotetrameric interface [polypeptide binding]; other site 1121448001169 putative phosphate binding site [ion binding]; other site 1121448001170 putative allosteric binding site; other site 1121448001171 PUA domain; Region: PUA; pfam01472 1121448001172 GTP1/OBG; Region: GTP1_OBG; pfam01018 1121448001173 GTPase CgtA; Reviewed; Region: obgE; PRK12299 1121448001174 GTP1/OBG; Region: GTP1_OBG; pfam01018 1121448001175 Obg GTPase; Region: Obg; cd01898 1121448001176 G1 box; other site 1121448001177 GTP/Mg2+ binding site [chemical binding]; other site 1121448001178 Switch I region; other site 1121448001179 G2 box; other site 1121448001180 G3 box; other site 1121448001181 Switch II region; other site 1121448001182 G4 box; other site 1121448001183 G5 box; other site 1121448001184 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1121448001185 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 1121448001186 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 1121448001187 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 1121448001188 TPR repeat; Region: TPR_11; pfam13414 1121448001189 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1121448001190 binding surface 1121448001191 TPR repeat; Region: TPR_11; pfam13414 1121448001192 TPR motif; other site 1121448001193 TPR repeat; Region: TPR_11; pfam13414 1121448001194 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1121448001195 binding surface 1121448001196 TPR motif; other site 1121448001197 TPR repeat; Region: TPR_11; pfam13414 1121448001198 putative transporter; Provisional; Region: PRK11660 1121448001199 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1121448001200 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1121448001201 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1121448001202 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 1121448001203 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 1121448001204 octaheme c-type cytochrome, tetrathionate reductase family; Region: octaheme_Shew; TIGR04315 1121448001205 Cytochrome c bacterial; Region: Cytochrome_cB; pfam11783 1121448001206 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 1121448001207 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121448001208 PAS domain; Region: PAS_9; pfam13426 1121448001209 putative active site [active] 1121448001210 heme pocket [chemical binding]; other site 1121448001211 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 1121448001212 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1121448001213 Walker A motif; other site 1121448001214 ATP binding site [chemical binding]; other site 1121448001215 Walker B motif; other site 1121448001216 arginine finger; other site 1121448001217 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1121448001218 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 1121448001219 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1121448001220 dimerization interface [polypeptide binding]; other site 1121448001221 PAS domain; Region: PAS_9; pfam13426 1121448001222 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121448001223 putative active site [active] 1121448001224 heme pocket [chemical binding]; other site 1121448001225 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1121448001226 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1121448001227 dimer interface [polypeptide binding]; other site 1121448001228 putative CheW interface [polypeptide binding]; other site 1121448001229 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1121448001230 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1121448001231 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1121448001232 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1121448001233 active site 1121448001234 transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283 1121448001235 GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Region: GT_2_like_a; cd02522 1121448001236 Probable Catalytic site; other site 1121448001237 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 1121448001238 Protein export membrane protein; Region: SecD_SecF; cl14618 1121448001239 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1121448001240 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1121448001241 HlyD family secretion protein; Region: HlyD_3; pfam13437 1121448001242 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1121448001243 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1121448001244 Domain of unknown function (DUF1956); Region: DUF1956; pfam09209 1121448001245 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 1121448001246 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1121448001247 flagellar basal-body rod protein FlgC; Region: FlgC; TIGR01395 1121448001248 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1121448001249 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1121448001250 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 1121448001251 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1121448001252 Walker A motif; other site 1121448001253 ATP binding site [chemical binding]; other site 1121448001254 Walker B motif; other site 1121448001255 arginine finger; other site 1121448001256 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1121448001257 Outer membrane lipoprotein; Region: YfiO; pfam13525 1121448001258 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1121448001259 binding surface 1121448001260 TPR motif; other site 1121448001261 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 1121448001262 Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility; Region: MEMO_like; cd07361 1121448001263 putative ligand binding pocket/active site [active] 1121448001264 putative metal binding site [ion binding]; other site 1121448001265 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 1121448001266 dimer interface [polypeptide binding]; other site 1121448001267 active site 1121448001268 putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605 1121448001269 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 1121448001270 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 1121448001271 domain interfaces; other site 1121448001272 active site 1121448001273 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1121448001274 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1121448001275 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1121448001276 dimer interface [polypeptide binding]; other site 1121448001277 putative CheW interface [polypeptide binding]; other site 1121448001278 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 1121448001279 STAS domain; Region: STAS_2; pfam13466 1121448001280 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1121448001281 putative binding surface; other site 1121448001282 active site 1121448001283 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 1121448001284 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 1121448001285 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121448001286 ATP binding site [chemical binding]; other site 1121448001287 Mg2+ binding site [ion binding]; other site 1121448001288 G-X-G motif; other site 1121448001289 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 1121448001290 VanZ like family; Region: VanZ; cl01971 1121448001291 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 1121448001292 Thioredoxin; Region: Thioredoxin_4; pfam13462 1121448001293 Response regulator receiver domain; Region: Response_reg; pfam00072 1121448001294 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121448001295 active site 1121448001296 phosphorylation site [posttranslational modification] 1121448001297 intermolecular recognition site; other site 1121448001298 dimerization interface [polypeptide binding]; other site 1121448001299 Tim44-like domain; Region: Tim44; cl09208 1121448001300 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1121448001301 Cation efflux family; Region: Cation_efflux; pfam01545 1121448001302 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1121448001303 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cd00449 1121448001304 homodimer interface [polypeptide binding]; other site 1121448001305 substrate-cofactor binding pocket; other site 1121448001306 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1121448001307 catalytic residue [active] 1121448001308 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 1121448001309 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1121448001310 Hemerythrin; Region: Hemerythrin; cd12107 1121448001311 Fe binding site [ion binding]; other site 1121448001312 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 1121448001313 FAD binding site [chemical binding]; other site 1121448001314 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 1121448001315 active site 1121448001316 8-oxo-dGMP binding site [chemical binding]; other site 1121448001317 nudix motif; other site 1121448001318 metal binding site [ion binding]; metal-binding site 1121448001319 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 1121448001320 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1121448001321 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1121448001322 catalytic residue [active] 1121448001323 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 1121448001324 4Fe-4S single cluster domain; Region: Fer4_13; pfam13370 1121448001325 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 1121448001326 NADPH bind site [chemical binding]; other site 1121448001327 putative FMN binding site [chemical binding]; other site 1121448001328 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 1121448001329 putative FMN binding site [chemical binding]; other site 1121448001330 NADPH bind site [chemical binding]; other site 1121448001331 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1121448001332 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1121448001333 Walker A/P-loop; other site 1121448001334 ATP binding site [chemical binding]; other site 1121448001335 Q-loop/lid; other site 1121448001336 ABC transporter signature motif; other site 1121448001337 Walker B; other site 1121448001338 D-loop; other site 1121448001339 H-loop/switch region; other site 1121448001340 seryl-tRNA synthetase; Provisional; Region: PRK05431 1121448001341 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1121448001342 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1121448001343 dimer interface [polypeptide binding]; other site 1121448001344 active site 1121448001345 motif 1; other site 1121448001346 motif 2; other site 1121448001347 motif 3; other site 1121448001348 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1121448001349 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1121448001350 dimerization interface [polypeptide binding]; other site 1121448001351 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1121448001352 dimer interface [polypeptide binding]; other site 1121448001353 putative CheW interface [polypeptide binding]; other site 1121448001354 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 1121448001355 putative CheA interaction surface; other site 1121448001356 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 1121448001357 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1121448001358 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1121448001359 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 1121448001360 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1121448001361 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1121448001362 dimer interface [polypeptide binding]; other site 1121448001363 putative anticodon binding site; other site 1121448001364 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 1121448001365 motif 1; other site 1121448001366 active site 1121448001367 motif 2; other site 1121448001368 motif 3; other site 1121448001369 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 1121448001370 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1121448001371 FtsX-like permease family; Region: FtsX; pfam02687 1121448001372 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1121448001373 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1121448001374 Walker A/P-loop; other site 1121448001375 ATP binding site [chemical binding]; other site 1121448001376 Q-loop/lid; other site 1121448001377 ABC transporter signature motif; other site 1121448001378 Walker B; other site 1121448001379 D-loop; other site 1121448001380 H-loop/switch region; other site 1121448001381 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 1121448001382 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1121448001383 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1121448001384 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1121448001385 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1121448001386 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1121448001387 Surface antigen; Region: Bac_surface_Ag; pfam01103 1121448001388 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 1121448001389 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1121448001390 Putative pyruvate format-lyase activating enzyme (DUF1786); Region: DUF1786; cl01638 1121448001391 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1121448001392 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 1121448001393 active site 1121448001394 CoA binding domain; Region: CoA_binding; smart00881 1121448001395 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 1121448001396 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 1121448001397 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 1121448001398 Walker A motif; other site 1121448001399 ATP binding site [chemical binding]; other site 1121448001400 Walker B motif; other site 1121448001401 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 1121448001402 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 1121448001403 Ligand Binding Site [chemical binding]; other site 1121448001404 TIGR00269 family protein; Region: TIGR00269 1121448001405 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 1121448001406 putative binding surface; other site 1121448001407 active site 1121448001408 Response regulator receiver domain; Region: Response_reg; pfam00072 1121448001409 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121448001410 active site 1121448001411 phosphorylation site [posttranslational modification] 1121448001412 intermolecular recognition site; other site 1121448001413 dimerization interface [polypeptide binding]; other site 1121448001414 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 1121448001415 Peptidase family M50; Region: Peptidase_M50; pfam02163 1121448001416 active site 1121448001417 putative substrate binding region [chemical binding]; other site 1121448001418 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1121448001419 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1121448001420 active site 1121448001421 HIGH motif; other site 1121448001422 dimer interface [polypeptide binding]; other site 1121448001423 KMSKS motif; other site 1121448001424 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 1121448001425 Competence protein; Region: Competence; pfam03772 1121448001426 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 1121448001427 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1121448001428 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1121448001429 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1121448001430 hinge; other site 1121448001431 active site 1121448001432 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 1121448001433 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 1121448001434 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 1121448001435 ATP-sulfurylase; Region: ATPS; cd00517 1121448001436 active site 1121448001437 HXXH motif; other site 1121448001438 flexible loop; other site 1121448001439 aconitate hydratase; Validated; Region: PRK07229 1121448001440 Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: AcnA_Bact; cd01585 1121448001441 substrate binding site [chemical binding]; other site 1121448001442 ligand binding site [chemical binding]; other site 1121448001443 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 1121448001444 substrate binding site [chemical binding]; other site 1121448001445 SurA N-terminal domain; Region: SurA_N_3; cl07813 1121448001446 nitrogen fixation protein NifM; Region: nifM_nitrog; TIGR02933 1121448001447 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1121448001448 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 1121448001449 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 1121448001450 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1121448001451 active site 1121448001452 metal binding site [ion binding]; metal-binding site 1121448001453 homotetramer interface [polypeptide binding]; other site 1121448001454 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1121448001455 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1121448001456 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1121448001457 multidrug efflux system protein MdtE; Provisional; Region: PRK09859 1121448001458 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1121448001459 HlyD family secretion protein; Region: HlyD_3; pfam13437 1121448001460 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 1121448001461 Protein export membrane protein; Region: SecD_SecF; cl14618 1121448001462 Protein export membrane protein; Region: SecD_SecF; cl14618 1121448001463 conjugal transfer relaxosome component TraJ; Provisional; Region: PRK13877 1121448001464 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 1121448001465 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 1121448001466 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 1121448001467 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1121448001468 Catalytic site [active] 1121448001469 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 1121448001470 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 1121448001471 active site 1121448001472 DNA binding site [nucleotide binding] 1121448001473 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 1121448001474 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 1121448001475 putative active site [active] 1121448001476 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 1121448001477 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1121448001478 cofactor binding site; other site 1121448001479 DNA binding site [nucleotide binding] 1121448001480 substrate interaction site [chemical binding]; other site 1121448001481 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 1121448001482 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1121448001483 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c_3; pfam13589 1121448001484 ATP binding site [chemical binding]; other site 1121448001485 Mg2+ binding site [ion binding]; other site 1121448001486 G-X-G motif; other site 1121448001487 Z1 domain; Region: Z1; pfam10593 1121448001488 Domain of unknown function (DUF4420); Region: DUF4420; pfam14390 1121448001489 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 1121448001490 Part of AAA domain; Region: AAA_19; pfam13245 1121448001491 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 1121448001492 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1121448001493 Walker A/P-loop; other site 1121448001494 ATP binding site [chemical binding]; other site 1121448001495 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 1121448001496 putative active site [active] 1121448001497 putative metal-binding site [ion binding]; other site 1121448001498 Fic/DOC family N-terminal; Region: Fic_N; pfam13784 1121448001499 Fic family protein [Function unknown]; Region: COG3177 1121448001500 Fic/DOC family; Region: Fic; pfam02661 1121448001501 Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227 1121448001502 Domain of unknown function (DUF1738); Region: DUF1738; pfam08401 1121448001503 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4643 1121448001504 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 1121448001505 active site 1121448001506 metal binding site [ion binding]; metal-binding site 1121448001507 interdomain interaction site; other site 1121448001508 Signal peptidase, peptidase S26; Region: Peptidase_S26; pfam10502 1121448001509 conjugal transfer pilin processing protease TraF; Provisional; Region: PRK13838 1121448001510 conjugal transfer coupling protein TraG; Provisional; Region: PRK13880 1121448001511 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1121448001512 Walker A motif; other site 1121448001513 ATP binding site [chemical binding]; other site 1121448001514 Walker B motif; other site 1121448001515 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: HicB; COG4226 1121448001516 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1121448001517 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1121448001518 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185 1121448001519 AAA domain; Region: AAA_33; pfam13671 1121448001520 Protein of unknown function (DUF3024); Region: DUF3024; pfam11225 1121448001521 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1121448001522 dimerization interface [polypeptide binding]; other site 1121448001523 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1121448001524 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1121448001525 dimer interface [polypeptide binding]; other site 1121448001526 putative CheW interface [polypeptide binding]; other site 1121448001527 Methylamine utilisation protein MauE; Region: MauE; pfam07291 1121448001528 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1121448001529 active site residue [active] 1121448001530 flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496 1121448001531 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 1121448001532 Walker A motif/ATP binding site; other site 1121448001533 Walker B motif; other site 1121448001534 flagellar assembly protein H; Validated; Region: fliH; PRK06669 1121448001535 Flagellar assembly protein FliH; Region: FliH; pfam02108 1121448001536 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 1121448001537 MgtE intracellular N domain; Region: MgtE_N; cl15244 1121448001538 FliG C-terminal domain; Region: FliG_C; pfam01706 1121448001539 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 1121448001540 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 1121448001541 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 1121448001542 Flagellar hook-basal body complex protein FliE; Region: FliE; pfam02049 1121448001543 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 1121448001544 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1121448001545 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1121448001546 flagellar basal body rod protein FlgB; Provisional; Region: flgB; PRK12621 1121448001547 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 1121448001548 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1121448001549 binding surface 1121448001550 TPR motif; other site 1121448001551 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1121448001552 binding surface 1121448001553 TPR motif; other site 1121448001554 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1121448001555 purine monophosphate binding site [chemical binding]; other site 1121448001556 dimer interface [polypeptide binding]; other site 1121448001557 putative catalytic residues [active] 1121448001558 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 1121448001559 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1121448001560 HflX GTPase family; Region: HflX; cd01878 1121448001561 G1 box; other site 1121448001562 GTP/Mg2+ binding site [chemical binding]; other site 1121448001563 Switch I region; other site 1121448001564 G2 box; other site 1121448001565 G3 box; other site 1121448001566 Switch II region; other site 1121448001567 G4 box; other site 1121448001568 G5 box; other site 1121448001569 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 1121448001570 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 1121448001571 putative dimer interface [polypeptide binding]; other site 1121448001572 putative anticodon binding site; other site 1121448001573 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 1121448001574 homodimer interface [polypeptide binding]; other site 1121448001575 motif 1; other site 1121448001576 motif 2; other site 1121448001577 active site 1121448001578 motif 3; other site 1121448001579 flagellar assembly protein FliW; Provisional; Region: PRK13285 1121448001580 carbon storage regulator; Provisional; Region: PRK01712 1121448001581 flagellar hook-associated protein 3; Region: flagell_flgL; TIGR02550 1121448001582 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1121448001583 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1121448001584 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK08471 1121448001585 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1121448001586 Rod binding protein; Region: Rod-binding; cl01626 1121448001587 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1121448001588 Peptidase family M23; Region: Peptidase_M23; pfam01551 1121448001589 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 1121448001590 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 1121448001591 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK12696 1121448001592 Flagellar L-ring protein; Region: FlgH; pfam02107 1121448001593 SAF-like; Region: SAF_2; pfam13144 1121448001594 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 1121448001595 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 1121448001596 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1121448001597 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1121448001598 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 1121448001599 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1121448001600 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 1121448001601 TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663 1121448001602 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 1121448001603 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 1121448001604 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 1121448001605 DctM-like transporters; Region: DctM; pfam06808 1121448001606 ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067 1121448001607 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 1121448001608 ethanolamine ammonia-lyase small subunit; Provisional; Region: PRK05465 1121448001609 NHL repeat; Region: NHL; pfam01436 1121448001610 NHL repeat; Region: NHL; pfam01436 1121448001611 NHL repeat; Region: NHL; pfam01436 1121448001612 NHL repeat; Region: NHL; pfam01436 1121448001613 NHL repeat; Region: NHL; pfam01436 1121448001614 NHL repeat; Region: NHL; pfam01436 1121448001615 NHL repeat; Region: NHL; pfam01436 1121448001616 NHL repeat; Region: NHL; pfam01436 1121448001617 NHL repeat; Region: NHL; pfam01436 1121448001618 NHL repeat; Region: NHL; pfam01436 1121448001619 NHL repeat; Region: NHL; pfam01436 1121448001620 NHL repeat; Region: NHL; pfam01436 1121448001621 Uncharacterized conserved protein [Function unknown]; Region: COG3379 1121448001622 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 1121448001623 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121448001624 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1121448001625 putative active site [active] 1121448001626 heme pocket [chemical binding]; other site 1121448001627 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121448001628 putative active site [active] 1121448001629 heme pocket [chemical binding]; other site 1121448001630 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121448001631 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1121448001632 putative active site [active] 1121448001633 heme pocket [chemical binding]; other site 1121448001634 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1121448001635 dimer interface [polypeptide binding]; other site 1121448001636 phosphorylation site [posttranslational modification] 1121448001637 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121448001638 ATP binding site [chemical binding]; other site 1121448001639 Mg2+ binding site [ion binding]; other site 1121448001640 G-X-G motif; other site 1121448001641 Response regulator receiver domain; Region: Response_reg; pfam00072 1121448001642 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121448001643 active site 1121448001644 phosphorylation site [posttranslational modification] 1121448001645 intermolecular recognition site; other site 1121448001646 dimerization interface [polypeptide binding]; other site 1121448001647 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1121448001648 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1121448001649 substrate binding pocket [chemical binding]; other site 1121448001650 membrane-bound complex binding site; other site 1121448001651 hinge residues; other site 1121448001652 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1121448001653 Part of AAA domain; Region: AAA_19; pfam13245 1121448001654 Family description; Region: UvrD_C_2; pfam13538 1121448001655 PAS domain; Region: PAS; smart00091 1121448001656 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1121448001657 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1121448001658 dimer interface [polypeptide binding]; other site 1121448001659 phosphorylation site [posttranslational modification] 1121448001660 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121448001661 ATP binding site [chemical binding]; other site 1121448001662 G-X-G motif; other site 1121448001663 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 1121448001664 active site 1121448001665 catalytic triad [active] 1121448001666 oxyanion hole [active] 1121448001667 switch loop; other site 1121448001668 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1121448001669 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1121448001670 Walker A/P-loop; other site 1121448001671 ATP binding site [chemical binding]; other site 1121448001672 Q-loop/lid; other site 1121448001673 ABC transporter signature motif; other site 1121448001674 Walker B; other site 1121448001675 D-loop; other site 1121448001676 H-loop/switch region; other site 1121448001677 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 1121448001678 FtsX-like permease family; Region: FtsX; pfam02687 1121448001679 Response regulator receiver domain; Region: Response_reg; pfam00072 1121448001680 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121448001681 active site 1121448001682 phosphorylation site [posttranslational modification] 1121448001683 intermolecular recognition site; other site 1121448001684 dimerization interface [polypeptide binding]; other site 1121448001685 Response regulator receiver domain; Region: Response_reg; pfam00072 1121448001686 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121448001687 active site 1121448001688 phosphorylation site [posttranslational modification] 1121448001689 intermolecular recognition site; other site 1121448001690 dimerization interface [polypeptide binding]; other site 1121448001691 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1121448001692 dimer interface [polypeptide binding]; other site 1121448001693 phosphorylation site [posttranslational modification] 1121448001694 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121448001695 ATP binding site [chemical binding]; other site 1121448001696 Mg2+ binding site [ion binding]; other site 1121448001697 G-X-G motif; other site 1121448001698 PAS domain; Region: PAS_9; pfam13426 1121448001699 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1121448001700 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1121448001701 Walker A motif; other site 1121448001702 ATP binding site [chemical binding]; other site 1121448001703 Walker B motif; other site 1121448001704 arginine finger; other site 1121448001705 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1121448001706 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1121448001707 phage shock protein operon transcriptional activator; Provisional; Region: pspF; PRK11608 1121448001708 Walker A motif; other site 1121448001709 ATP binding site [chemical binding]; other site 1121448001710 Walker B motif; other site 1121448001711 arginine finger; other site 1121448001712 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1121448001713 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 1121448001714 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845 1121448001715 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1121448001716 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1121448001717 HlyD family secretion protein; Region: HlyD_3; pfam13437 1121448001718 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1121448001719 PAS fold; Region: PAS_4; pfam08448 1121448001720 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1121448001721 dimer interface [polypeptide binding]; other site 1121448001722 phosphorylation site [posttranslational modification] 1121448001723 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121448001724 ATP binding site [chemical binding]; other site 1121448001725 Mg2+ binding site [ion binding]; other site 1121448001726 G-X-G motif; other site 1121448001727 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1121448001728 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121448001729 active site 1121448001730 phosphorylation site [posttranslational modification] 1121448001731 intermolecular recognition site; other site 1121448001732 dimerization interface [polypeptide binding]; other site 1121448001733 CHASE2 domain; Region: CHASE2; pfam05226 1121448001734 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1121448001735 cyclase homology domain; Region: CHD; cd07302 1121448001736 nucleotidyl binding site; other site 1121448001737 metal binding site [ion binding]; metal-binding site 1121448001738 dimer interface [polypeptide binding]; other site 1121448001739 Peptidase family M48; Region: Peptidase_M48; cl12018 1121448001740 Bacterial SH3 domain; Region: SH3_3; cl17532 1121448001741 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1121448001742 metal ion-dependent adhesion site (MIDAS); other site 1121448001743 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 1121448001744 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 1121448001745 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 1121448001746 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 1121448001747 catalytic triad [active] 1121448001748 Precorrin-8X methylmutase; Region: CbiC; pfam02570 1121448001749 cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; cl00913 1121448001750 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1121448001751 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 1121448001752 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 1121448001753 active site 1121448001754 putative homodimer interface [polypeptide binding]; other site 1121448001755 SAM binding site [chemical binding]; other site 1121448001756 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 1121448001757 precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; Region: CbiT; TIGR02469 1121448001758 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 1121448001759 active site 1121448001760 SAM binding site [chemical binding]; other site 1121448001761 homodimer interface [polypeptide binding]; other site 1121448001762 Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894 1121448001763 Domain of unknown function (DUF4412); Region: DUF4412; pfam14371 1121448001764 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1121448001765 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1121448001766 metal binding site [ion binding]; metal-binding site 1121448001767 active site 1121448001768 I-site; other site 1121448001769 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121448001770 active site 1121448001771 dimerization interface [polypeptide binding]; other site 1121448001772 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1121448001773 binding surface 1121448001774 TPR motif; other site 1121448001775 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1121448001776 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1121448001777 TPR motif; other site 1121448001778 binding surface 1121448001779 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1121448001780 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1121448001781 TPR motif; other site 1121448001782 TPR repeat; Region: TPR_11; pfam13414 1121448001783 binding surface 1121448001784 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1121448001785 binding surface 1121448001786 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1121448001787 TPR motif; other site 1121448001788 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 1121448001789 CoA binding domain; Region: CoA_binding_2; pfam13380 1121448001790 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 1121448001791 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 1121448001792 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1121448001793 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1121448001794 PAS domain; Region: PAS_9; pfam13426 1121448001795 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1121448001796 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1121448001797 metal binding site [ion binding]; metal-binding site 1121448001798 active site 1121448001799 I-site; other site 1121448001800 Response regulator receiver domain; Region: Response_reg; pfam00072 1121448001801 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121448001802 active site 1121448001803 phosphorylation site [posttranslational modification] 1121448001804 intermolecular recognition site; other site 1121448001805 dimerization interface [polypeptide binding]; other site 1121448001806 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 1121448001807 PAS domain; Region: PAS_9; pfam13426 1121448001808 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1121448001809 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1121448001810 dimer interface [polypeptide binding]; other site 1121448001811 phosphorylation site [posttranslational modification] 1121448001812 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121448001813 ATP binding site [chemical binding]; other site 1121448001814 Mg2+ binding site [ion binding]; other site 1121448001815 G-X-G motif; other site 1121448001816 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1121448001817 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1121448001818 substrate binding pocket [chemical binding]; other site 1121448001819 membrane-bound complex binding site; other site 1121448001820 hinge residues; other site 1121448001821 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1121448001822 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1121448001823 substrate binding pocket [chemical binding]; other site 1121448001824 membrane-bound complex binding site; other site 1121448001825 hinge residues; other site 1121448001826 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121448001827 ATP binding site [chemical binding]; other site 1121448001828 Mg2+ binding site [ion binding]; other site 1121448001829 G-X-G motif; other site 1121448001830 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051 1121448001831 EF-hand domain pair; Region: EF_hand_5; pfam13499 1121448001832 Ca2+ binding site [ion binding]; other site 1121448001833 EF-hand domain pair; Region: EF_hand_5; pfam13499 1121448001834 Ca2+-binding protein (EF-Hand superfamily) [Signal transduction mechanisms / Cytoskeleton / Cell division and chromosome partitioning / General function prediction only]; Region: FRQ1; COG5126 1121448001835 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051 1121448001836 Ca2+ binding site [ion binding]; other site 1121448001837 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1121448001838 dimerization interface [polypeptide binding]; other site 1121448001839 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1121448001840 dimer interface [polypeptide binding]; other site 1121448001841 phosphorylation site [posttranslational modification] 1121448001842 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121448001843 ATP binding site [chemical binding]; other site 1121448001844 Mg2+ binding site [ion binding]; other site 1121448001845 G-X-G motif; other site 1121448001846 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1121448001847 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121448001848 active site 1121448001849 phosphorylation site [posttranslational modification] 1121448001850 intermolecular recognition site; other site 1121448001851 dimerization interface [polypeptide binding]; other site 1121448001852 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1121448001853 DNA binding site [nucleotide binding] 1121448001854 Protein of unknown function, DUF486; Region: DUF486; cl01236 1121448001855 acetyl-CoA synthetase; Provisional; Region: PRK00174 1121448001856 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 1121448001857 active site 1121448001858 CoA binding site [chemical binding]; other site 1121448001859 acyl-activating enzyme (AAE) consensus motif; other site 1121448001860 AMP binding site [chemical binding]; other site 1121448001861 acetate binding site [chemical binding]; other site 1121448001862 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1121448001863 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 1121448001864 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1121448001865 dimerization interface [polypeptide binding]; other site 1121448001866 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1121448001867 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1121448001868 dimer interface [polypeptide binding]; other site 1121448001869 putative CheW interface [polypeptide binding]; other site 1121448001870 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 1121448001871 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1121448001872 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 1121448001873 PHP family phosphoesterase with a Zn ribbon [General function prediction only]; Region: COG1379 1121448001874 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 1121448001875 Herpes virus protein UL24; Region: Herpes_UL24; cl17308 1121448001876 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1121448001877 Family description; Region: UvrD_C_2; pfam13538 1121448001878 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1121448001879 Walker A motif; other site 1121448001880 ATP binding site [chemical binding]; other site 1121448001881 Walker B motif; other site 1121448001882 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 1121448001883 DHH family; Region: DHH; pfam01368 1121448001884 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 1121448001885 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1121448001886 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 1121448001887 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 1121448001888 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 1121448001889 putative active site; other site 1121448001890 catalytic residue [active] 1121448001891 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 1121448001892 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 1121448001893 putative active site; other site 1121448001894 catalytic residue [active] 1121448001895 Predicted alternative 3-dehydroquinate synthase [Amino acid transport and metabolism]; Region: COG1465 1121448001896 3-dehydroquinate synthase; Provisional; Region: PRK02290 1121448001897 Chorismate mutase type II; Region: CM_2; pfam01817 1121448001898 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 1121448001899 Prephenate dehydratase; Region: PDT; pfam00800 1121448001900 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 1121448001901 putative L-Phe binding site [chemical binding]; other site 1121448001902 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 1121448001903 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 1121448001904 active site 1121448001905 hinge; other site 1121448001906 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 1121448001907 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1121448001908 NAD binding site [chemical binding]; other site 1121448001909 arogenate dehydrogenase; Region: PLN02256 1121448001910 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 1121448001911 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1121448001912 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1121448001913 Glutamine amidotransferase class-I; Region: GATase; pfam00117 1121448001914 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1121448001915 glutamine binding [chemical binding]; other site 1121448001916 catalytic triad [active] 1121448001917 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 1121448001918 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1121448001919 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1121448001920 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1121448001921 active site 1121448001922 ribulose/triose binding site [chemical binding]; other site 1121448001923 phosphate binding site [ion binding]; other site 1121448001924 substrate (anthranilate) binding pocket [chemical binding]; other site 1121448001925 product (indole) binding pocket [chemical binding]; other site 1121448001926 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 1121448001927 active site 1121448001928 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 1121448001929 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1121448001930 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1121448001931 catalytic residue [active] 1121448001932 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 1121448001933 substrate binding site [chemical binding]; other site 1121448001934 active site 1121448001935 catalytic residues [active] 1121448001936 heterodimer interface [polypeptide binding]; other site 1121448001937 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 1121448001938 Ca2+ binding site [ion binding]; other site 1121448001939 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 1121448001940 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1121448001941 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1121448001942 homodimer interface [polypeptide binding]; other site 1121448001943 catalytic residue [active] 1121448001944 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1121448001945 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1121448001946 catalytic residues [active] 1121448001947 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1121448001948 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1121448001949 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 1121448001950 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 1121448001951 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 1121448001952 Walker A motif; other site 1121448001953 ATP binding site [chemical binding]; other site 1121448001954 Walker B motif; other site 1121448001955 FtsH Extracellular; Region: FtsH_ext; pfam06480 1121448001956 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 1121448001957 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1121448001958 Walker A motif; other site 1121448001959 ATP binding site [chemical binding]; other site 1121448001960 Walker B motif; other site 1121448001961 arginine finger; other site 1121448001962 Peptidase family M41; Region: Peptidase_M41; pfam01434 1121448001963 EamA-like transporter family; Region: EamA; pfam00892 1121448001964 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1121448001965 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1121448001966 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1121448001967 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1121448001968 NMT1/THI5 like; Region: NMT1; pfam09084 1121448001969 PAS domain S-box; Region: sensory_box; TIGR00229 1121448001970 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121448001971 putative active site [active] 1121448001972 heme pocket [chemical binding]; other site 1121448001973 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1121448001974 PAS domain; Region: PAS; smart00091 1121448001975 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1121448001976 dimer interface [polypeptide binding]; other site 1121448001977 phosphorylation site [posttranslational modification] 1121448001978 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121448001979 ATP binding site [chemical binding]; other site 1121448001980 Mg2+ binding site [ion binding]; other site 1121448001981 G-X-G motif; other site 1121448001982 Response regulator receiver domain; Region: Response_reg; pfam00072 1121448001983 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121448001984 active site 1121448001985 phosphorylation site [posttranslational modification] 1121448001986 intermolecular recognition site; other site 1121448001987 dimerization interface [polypeptide binding]; other site 1121448001988 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 1121448001989 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121448001990 Mg2+ binding site [ion binding]; other site 1121448001991 G-X-G motif; other site 1121448001992 CheW-like domain; Region: CheW; pfam01584 1121448001993 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1121448001994 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1121448001995 metal binding site [ion binding]; metal-binding site 1121448001996 active site 1121448001997 I-site; other site 1121448001998 Domain of unknown function (DUF1987); Region: DUF1987; pfam09345 1121448001999 Ferrous iron transport protein B; Region: FeoB_N; pfam02421 1121448002000 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 1121448002001 G1 box; other site 1121448002002 GTP/Mg2+ binding site [chemical binding]; other site 1121448002003 Switch I region; other site 1121448002004 G2 box; other site 1121448002005 G3 box; other site 1121448002006 Switch II region; other site 1121448002007 G4 box; other site 1121448002008 G5 box; other site 1121448002009 Nucleoside recognition; Region: Gate; pfam07670 1121448002010 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 1121448002011 Nucleoside recognition; Region: Gate; pfam07670 1121448002012 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1121448002013 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 1121448002014 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1121448002015 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1121448002016 motif II; other site 1121448002017 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1121448002018 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1121448002019 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1121448002020 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 1121448002021 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1121448002022 Zn2+ binding site [ion binding]; other site 1121448002023 Mg2+ binding site [ion binding]; other site 1121448002024 Domain of unknown function (DUF4198); Region: DUF4198; pfam10670 1121448002025 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 1121448002026 Formylmethanofuran dehydrogenase subunit E [Energy production and conversion]; Region: COG2191 1121448002027 FmdE, Molybdenum formylmethanofuran dehydrogenase operon; Region: FmdE; pfam02663 1121448002028 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; pfam01258 1121448002029 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1121448002030 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1121448002031 Walker A/P-loop; other site 1121448002032 ATP binding site [chemical binding]; other site 1121448002033 Q-loop/lid; other site 1121448002034 ABC transporter signature motif; other site 1121448002035 Walker B; other site 1121448002036 D-loop; other site 1121448002037 H-loop/switch region; other site 1121448002038 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1121448002039 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1121448002040 ABC-ATPase subunit interface; other site 1121448002041 dimer interface [polypeptide binding]; other site 1121448002042 putative PBP binding regions; other site 1121448002043 Metal binding protein HemV-2. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: HemV-2; cd01147 1121448002044 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1121448002045 putative metal binding site [ion binding]; other site 1121448002046 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 1121448002047 Histone acetyltransferase [Transcription / Chromatin structure and dynamics]; Region: ELP3; COG1243 1121448002048 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 1121448002049 nucleotide binding site/active site [active] 1121448002050 HIT family signature motif; other site 1121448002051 catalytic residue [active] 1121448002052 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1121448002053 IHF - DNA interface [nucleotide binding]; other site 1121448002054 IHF dimer interface [polypeptide binding]; other site 1121448002055 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 1121448002056 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 1121448002057 Sporulation related domain; Region: SPOR; pfam05036 1121448002058 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 1121448002059 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 1121448002060 active site 1121448002061 catalytic residues [active] 1121448002062 metal binding site [ion binding]; metal-binding site 1121448002063 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1121448002064 CoenzymeA binding site [chemical binding]; other site 1121448002065 subunit interaction site [polypeptide binding]; other site 1121448002066 PHB binding site; other site 1121448002067 Response regulator receiver domain; Region: Response_reg; pfam00072 1121448002068 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121448002069 active site 1121448002070 phosphorylation site [posttranslational modification] 1121448002071 intermolecular recognition site; other site 1121448002072 dimerization interface [polypeptide binding]; other site 1121448002073 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1121448002074 binding surface 1121448002075 TPR motif; other site 1121448002076 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1121448002077 binding surface 1121448002078 TPR motif; other site 1121448002079 TPR repeat; Region: TPR_11; pfam13414 1121448002080 putative molybdopterin biosynthesis protein MoeA/LysR substrate binding-domain-containing protein; Provisional; Region: PRK14498 1121448002081 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1121448002082 dimer interface [polypeptide binding]; other site 1121448002083 putative functional site; other site 1121448002084 putative MPT binding site; other site 1121448002085 PBP superfamily domain; Region: PBP_like; pfam12727 1121448002086 phosphodiesterase; Provisional; Region: PRK12704 1121448002087 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1121448002088 Zn2+ binding site [ion binding]; other site 1121448002089 Mg2+ binding site [ion binding]; other site 1121448002090 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14356 1121448002091 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1121448002092 Substrate binding site; other site 1121448002093 Mg++ binding site; other site 1121448002094 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 1121448002095 active site 1121448002096 substrate binding site [chemical binding]; other site 1121448002097 CoA binding site [chemical binding]; other site 1121448002098 F0F1 ATP synthase subunit epsilon; Provisional; Region: atpC; PRK13446 1121448002099 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1121448002100 gamma subunit interface [polypeptide binding]; other site 1121448002101 epsilon subunit interface [polypeptide binding]; other site 1121448002102 LBP interface [polypeptide binding]; other site 1121448002103 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1121448002104 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1121448002105 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1121448002106 alpha subunit interaction interface [polypeptide binding]; other site 1121448002107 Walker A motif; other site 1121448002108 ATP binding site [chemical binding]; other site 1121448002109 Walker B motif; other site 1121448002110 inhibitor binding site; inhibition site 1121448002111 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1121448002112 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1121448002113 core domain interface [polypeptide binding]; other site 1121448002114 delta subunit interface [polypeptide binding]; other site 1121448002115 epsilon subunit interface [polypeptide binding]; other site 1121448002116 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1121448002117 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1121448002118 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 1121448002119 beta subunit interaction interface [polypeptide binding]; other site 1121448002120 Walker A motif; other site 1121448002121 ATP binding site [chemical binding]; other site 1121448002122 Walker B motif; other site 1121448002123 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1121448002124 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13429 1121448002125 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 1121448002126 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 1121448002127 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 1121448002128 ATP synthase B/B' CF(0); Region: ATP-synt_B; pfam00430 1121448002129 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 1121448002130 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 1121448002131 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 1121448002132 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1121448002133 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1121448002134 rod shape-determining protein MreC; Provisional; Region: PRK13922 1121448002135 rod shape-determining protein MreC; Region: MreC; pfam04085 1121448002136 rod shape-determining protein MreB; Provisional; Region: PRK13927 1121448002137 MreB and similar proteins; Region: MreB_like; cd10225 1121448002138 nucleotide binding site [chemical binding]; other site 1121448002139 Mg binding site [ion binding]; other site 1121448002140 putative protofilament interaction site [polypeptide binding]; other site 1121448002141 RodZ interaction site [polypeptide binding]; other site 1121448002142 radical SAM protein, TIGR01212 family; Region: TIGR01212 1121448002143 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1121448002144 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1121448002145 dimer interface [polypeptide binding]; other site 1121448002146 putative CheW interface [polypeptide binding]; other site 1121448002147 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 1121448002148 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1121448002149 DNA binding site [nucleotide binding] 1121448002150 active site 1121448002151 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 1121448002152 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 1121448002153 tandem repeat interface [polypeptide binding]; other site 1121448002154 oligomer interface [polypeptide binding]; other site 1121448002155 active site residues [active] 1121448002156 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 1121448002157 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 1121448002158 RNA binding site [nucleotide binding]; other site 1121448002159 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1121448002160 RNA binding site [nucleotide binding]; other site 1121448002161 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1121448002162 RNA binding site [nucleotide binding]; other site 1121448002163 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1121448002164 RNA binding site [nucleotide binding]; other site 1121448002165 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1121448002166 RNA binding site [nucleotide binding]; other site 1121448002167 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1121448002168 RNA binding site [nucleotide binding]; other site 1121448002169 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 1121448002170 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1121448002171 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1121448002172 FeS/SAM binding site; other site 1121448002173 TRAM domain; Region: TRAM; cl01282 1121448002174 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1121448002175 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121448002176 putative active site [active] 1121448002177 heme pocket [chemical binding]; other site 1121448002178 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1121448002179 dimer interface [polypeptide binding]; other site 1121448002180 phosphorylation site [posttranslational modification] 1121448002181 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121448002182 ATP binding site [chemical binding]; other site 1121448002183 Mg2+ binding site [ion binding]; other site 1121448002184 G-X-G motif; other site 1121448002185 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1121448002186 active site 1121448002187 dimerization interface [polypeptide binding]; other site 1121448002188 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1121448002189 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1121448002190 glutaminase active site [active] 1121448002191 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1121448002192 dimer interface [polypeptide binding]; other site 1121448002193 active site 1121448002194 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1121448002195 dimer interface [polypeptide binding]; other site 1121448002196 active site 1121448002197 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 1121448002198 AMIN domain; Region: AMIN; pfam11741 1121448002199 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1121448002200 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1121448002201 active site 1121448002202 metal binding site [ion binding]; metal-binding site 1121448002203 DNA polymerase I; Provisional; Region: PRK05755 1121448002204 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1121448002205 active site 1121448002206 metal binding site 1 [ion binding]; metal-binding site 1121448002207 putative 5' ssDNA interaction site; other site 1121448002208 metal binding site 3; metal-binding site 1121448002209 metal binding site 2 [ion binding]; metal-binding site 1121448002210 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1121448002211 putative DNA binding site [nucleotide binding]; other site 1121448002212 putative metal binding site [ion binding]; other site 1121448002213 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 1121448002214 active site 1121448002215 substrate binding site [chemical binding]; other site 1121448002216 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1121448002217 active site 1121448002218 DNA binding site [nucleotide binding] 1121448002219 catalytic site [active] 1121448002220 Domain of unknown function (DUF1844); Region: DUF1844; pfam08899 1121448002221 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 1121448002222 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1121448002223 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1121448002224 Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434 1121448002225 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1121448002226 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1121448002227 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 1121448002228 acyl-activating enzyme (AAE) consensus motif; other site 1121448002229 AMP binding site [chemical binding]; other site 1121448002230 active site 1121448002231 CoA binding site [chemical binding]; other site 1121448002232 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 1121448002233 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1121448002234 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 1121448002235 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1121448002236 AIR carboxylase; Region: AIRC; pfam00731 1121448002237 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 1121448002238 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121448002239 ATP binding site [chemical binding]; other site 1121448002240 Mg2+ binding site [ion binding]; other site 1121448002241 G-X-G motif; other site 1121448002242 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 1121448002243 ATP binding site [chemical binding]; other site 1121448002244 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 1121448002245 ADP-L-glycero-D-manno-heptose-6-epimerase; Region: heptose_epim; TIGR02197 1121448002246 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 1121448002247 NADP binding site [chemical binding]; other site 1121448002248 homopentamer interface [polypeptide binding]; other site 1121448002249 substrate binding site [chemical binding]; other site 1121448002250 active site 1121448002251 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1121448002252 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1121448002253 active site 1121448002254 ATP binding site [chemical binding]; other site 1121448002255 substrate binding site [chemical binding]; other site 1121448002256 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1121448002257 substrate binding site [chemical binding]; other site 1121448002258 activation loop (A-loop); other site 1121448002259 activation loop (A-loop); other site 1121448002260 Protein of unknown function (DUF1566); Region: DUF1566; pfam07603 1121448002261 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 1121448002262 active site 1121448002263 metal binding site [ion binding]; metal-binding site 1121448002264 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 1121448002265 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 1121448002266 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 1121448002267 catalytic triad [active] 1121448002268 Dissimilatory sulfite reductase D (DsrD); Region: DsrD; pfam08679 1121448002269 sulfite reductase, dissimilatory-type beta subunit; Region: dsrB; TIGR02066 1121448002270 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1121448002271 sulfite reductase, dissimilatory-type alpha subunit; Region: dsrA; TIGR02064 1121448002272 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 1121448002273 Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467 1121448002274 GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Region: GT_2_like_a; cd02522 1121448002275 transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283 1121448002276 Probable Catalytic site; other site 1121448002277 transferase 1, rSAM/selenodomain-associated; Region: glyco_like_cofC; TIGR04282 1121448002278 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 1121448002279 FMN binding site [chemical binding]; other site 1121448002280 dimer interface [polypeptide binding]; other site 1121448002281 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1121448002282 FeS/SAM binding site; other site 1121448002283 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 1121448002284 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1121448002285 RNA binding surface [nucleotide binding]; other site 1121448002286 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1121448002287 S-adenosylmethionine binding site [chemical binding]; other site 1121448002288 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14184 1121448002289 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1121448002290 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1121448002291 homodimer interface [polypeptide binding]; other site 1121448002292 NADP binding site [chemical binding]; other site 1121448002293 substrate binding site [chemical binding]; other site 1121448002294 enolase; Provisional; Region: eno; PRK00077 1121448002295 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1121448002296 dimer interface [polypeptide binding]; other site 1121448002297 metal binding site [ion binding]; metal-binding site 1121448002298 substrate binding pocket [chemical binding]; other site 1121448002299 Type III pantothenate kinase; Region: Pan_kinase; cl17198 1121448002300 GPR1/FUN34/yaaH family; Region: Grp1_Fun34_YaaH; cl00685 1121448002301 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1121448002302 binding surface 1121448002303 TPR motif; other site 1121448002304 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 1121448002305 active site 1121448002306 phosphorylation site [posttranslational modification] 1121448002307 intermolecular recognition site; other site 1121448002308 dimerization interface [polypeptide binding]; other site 1121448002309 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1121448002310 binding surface 1121448002311 PAS fold; Region: PAS_4; pfam08448 1121448002312 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1121448002313 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1121448002314 PAS domain; Region: PAS_8; pfam13188 1121448002315 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1121448002316 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1121448002317 dimer interface [polypeptide binding]; other site 1121448002318 phosphorylation site [posttranslational modification] 1121448002319 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121448002320 ATP binding site [chemical binding]; other site 1121448002321 Mg2+ binding site [ion binding]; other site 1121448002322 G-X-G motif; other site 1121448002323 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 1121448002324 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 1121448002325 active site 1121448002326 NAD binding site [chemical binding]; other site 1121448002327 metal binding site [ion binding]; metal-binding site 1121448002328 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121448002329 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1121448002330 putative active site [active] 1121448002331 heme pocket [chemical binding]; other site 1121448002332 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121448002333 putative active site [active] 1121448002334 heme pocket [chemical binding]; other site 1121448002335 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1121448002336 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121448002337 putative active site [active] 1121448002338 heme pocket [chemical binding]; other site 1121448002339 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1121448002340 dimer interface [polypeptide binding]; other site 1121448002341 phosphorylation site [posttranslational modification] 1121448002342 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121448002343 ATP binding site [chemical binding]; other site 1121448002344 Mg2+ binding site [ion binding]; other site 1121448002345 G-X-G motif; other site 1121448002346 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121448002347 Response regulator receiver domain; Region: Response_reg; pfam00072 1121448002348 active site 1121448002349 phosphorylation site [posttranslational modification] 1121448002350 intermolecular recognition site; other site 1121448002351 dimerization interface [polypeptide binding]; other site 1121448002352 fructose-bisphosphate aldolase; Provisional; Region: PRK09250 1121448002353 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 1121448002354 putative active site; other site 1121448002355 catalytic residue [active] 1121448002356 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 1121448002357 heme-binding residues [chemical binding]; other site 1121448002358 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 1121448002359 heme-binding residues [chemical binding]; other site 1121448002360 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 1121448002361 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 1121448002362 heme-binding residues [chemical binding]; other site 1121448002363 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 1121448002364 heme-binding residues [chemical binding]; other site 1121448002365 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 1121448002366 Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901 1121448002367 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 1121448002368 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959 1121448002369 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1121448002370 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1121448002371 Ligand Binding Site [chemical binding]; other site 1121448002372 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1121448002373 Ligand Binding Site [chemical binding]; other site 1121448002374 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1121448002375 binding surface 1121448002376 TPR motif; other site 1121448002377 TPR repeat; Region: TPR_11; pfam13414 1121448002378 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1121448002379 binding surface 1121448002380 TPR motif; other site 1121448002381 TPR repeat; Region: TPR_11; pfam13414 1121448002382 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1121448002383 rRNA binding site [nucleotide binding]; other site 1121448002384 predicted 30S ribosome binding site; other site 1121448002385 MoxR-like ATPases [General function prediction only]; Region: COG0714 1121448002386 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1121448002387 Walker A motif; other site 1121448002388 ATP binding site [chemical binding]; other site 1121448002389 Walker B motif; other site 1121448002390 arginine finger; other site 1121448002391 Protein of unknown function DUF58; Region: DUF58; pfam01882 1121448002392 Domain of unknown function (DUF3488); Region: DUF3488; pfam11992 1121448002393 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1121448002394 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1121448002395 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 1121448002396 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1121448002397 Permease; Region: Permease; pfam02405 1121448002398 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1121448002399 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1121448002400 Walker A/P-loop; other site 1121448002401 ATP binding site [chemical binding]; other site 1121448002402 Q-loop/lid; other site 1121448002403 ABC transporter signature motif; other site 1121448002404 Walker B; other site 1121448002405 D-loop; other site 1121448002406 H-loop/switch region; other site 1121448002407 mce related protein; Region: MCE; pfam02470 1121448002408 Bacterial type III secretion protein (HrpB7); Region: HrpB7; cl09720 1121448002409 Protein of unknown function (DUF330); Region: DUF330; pfam03886 1121448002410 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1121448002411 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306 1121448002412 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1121448002413 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1121448002414 dimer interface [polypeptide binding]; other site 1121448002415 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1121448002416 catalytic residue [active] 1121448002417 serine O-acetyltransferase; Region: cysE; TIGR01172 1121448002418 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1121448002419 trimer interface [polypeptide binding]; other site 1121448002420 active site 1121448002421 substrate binding site [chemical binding]; other site 1121448002422 CoA binding site [chemical binding]; other site 1121448002423 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 1121448002424 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 1121448002425 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1121448002426 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1121448002427 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1121448002428 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 1121448002429 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1121448002430 catalytic site [active] 1121448002431 subunit interface [polypeptide binding]; other site 1121448002432 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1121448002433 TPR motif; other site 1121448002434 binding surface 1121448002435 TPR repeat; Region: TPR_11; pfam13414 1121448002436 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 1121448002437 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1121448002438 NAD binding site [chemical binding]; other site 1121448002439 catalytic residues [active] 1121448002440 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1121448002441 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1121448002442 substrate binding pocket [chemical binding]; other site 1121448002443 membrane-bound complex binding site; other site 1121448002444 hinge residues; other site 1121448002445 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1121448002446 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1121448002447 metal binding site [ion binding]; metal-binding site 1121448002448 active site 1121448002449 I-site; other site 1121448002450 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121448002451 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1121448002452 putative active site [active] 1121448002453 heme pocket [chemical binding]; other site 1121448002454 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121448002455 putative active site [active] 1121448002456 heme pocket [chemical binding]; other site 1121448002457 PAS domain S-box; Region: sensory_box; TIGR00229 1121448002458 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121448002459 putative active site [active] 1121448002460 heme pocket [chemical binding]; other site 1121448002461 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1121448002462 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1121448002463 dimer interface [polypeptide binding]; other site 1121448002464 phosphorylation site [posttranslational modification] 1121448002465 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121448002466 ATP binding site [chemical binding]; other site 1121448002467 G-X-G motif; other site 1121448002468 ferric uptake regulator; Provisional; Region: fur; PRK09462 1121448002469 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1121448002470 metal binding site 2 [ion binding]; metal-binding site 1121448002471 putative DNA binding helix; other site 1121448002472 metal binding site 1 [ion binding]; metal-binding site 1121448002473 dimer interface [polypeptide binding]; other site 1121448002474 structural Zn2+ binding site [ion binding]; other site 1121448002475 Rubrerythrin [Energy production and conversion]; Region: COG1592 1121448002476 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 1121448002477 binuclear metal center [ion binding]; other site 1121448002478 Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cl00202 1121448002479 iron binding site [ion binding]; other site 1121448002480 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 1121448002481 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 1121448002482 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 1121448002483 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 1121448002484 active site 1121448002485 homotetramer interface [polypeptide binding]; other site 1121448002486 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1121448002487 anti sigma factor interaction site; other site 1121448002488 regulatory phosphorylation site [posttranslational modification]; other site 1121448002489 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; cl17549 1121448002490 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121448002491 dimer interface [polypeptide binding]; other site 1121448002492 conserved gate region; other site 1121448002493 putative PBP binding loops; other site 1121448002494 ABC-ATPase subunit interface; other site 1121448002495 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1121448002496 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1121448002497 Walker A/P-loop; other site 1121448002498 ATP binding site [chemical binding]; other site 1121448002499 Q-loop/lid; other site 1121448002500 ABC transporter signature motif; other site 1121448002501 Walker B; other site 1121448002502 D-loop; other site 1121448002503 H-loop/switch region; other site 1121448002504 Protein involved in formate dehydrogenase formation; Region: FdhE; pfam04216 1121448002505 formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562 1121448002506 FdhD/NarQ family; Region: FdhD-NarQ; cl00659 1121448002507 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 1121448002508 GTP binding site; other site 1121448002509 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1121448002510 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1121448002511 catalytic residues [active] 1121448002512 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 1121448002513 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1121448002514 FeS/SAM binding site; other site 1121448002515 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1121448002516 Radical SAM superfamily; Region: Radical_SAM; pfam04055 1121448002517 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1121448002518 FeS/SAM binding site; other site 1121448002519 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 1121448002520 active site 1121448002521 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 1121448002522 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 1121448002523 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1121448002524 putative 2-aminoethylphosphonate ABC transporter, ATP-binding protein; Region: PhnT2; TIGR03265 1121448002525 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1121448002526 Walker A/P-loop; other site 1121448002527 ATP binding site [chemical binding]; other site 1121448002528 Q-loop/lid; other site 1121448002529 ABC transporter signature motif; other site 1121448002530 Walker B; other site 1121448002531 D-loop; other site 1121448002532 H-loop/switch region; other site 1121448002533 TOBE domain; Region: TOBE_2; pfam08402 1121448002534 putative 2-aminoethylphosphonate ABC transporter, permease protein; Region: PhnU2; TIGR03262 1121448002535 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121448002536 dimer interface [polypeptide binding]; other site 1121448002537 conserved gate region; other site 1121448002538 putative PBP binding loops; other site 1121448002539 ABC-ATPase subunit interface; other site 1121448002540 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121448002541 dimer interface [polypeptide binding]; other site 1121448002542 conserved gate region; other site 1121448002543 putative PBP binding loops; other site 1121448002544 ABC-ATPase subunit interface; other site 1121448002545 phosphonoacetaldehyde hydrolase; Provisional; Region: PRK13478 1121448002546 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1121448002547 motif II; other site 1121448002548 4-aminobutyrate aminotransferase; Provisional; Region: PRK06082 1121448002549 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1121448002550 inhibitor-cofactor binding pocket; inhibition site 1121448002551 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1121448002552 catalytic residue [active] 1121448002553 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1121448002554 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1121448002555 catalytic residue [active] 1121448002556 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1121448002557 hypothetical protein; Provisional; Region: PRK07208 1121448002558 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1121448002559 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1121448002560 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1121448002561 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1121448002562 active site 1121448002563 Protein of unknown function DUF45; Region: DUF45; pfam01863 1121448002564 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 1121448002565 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1121448002566 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1121448002567 metal binding site [ion binding]; metal-binding site 1121448002568 active site 1121448002569 I-site; other site 1121448002570 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1121448002571 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1121448002572 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1121448002573 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1121448002574 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1121448002575 metal binding site [ion binding]; metal-binding site 1121448002576 active site 1121448002577 I-site; other site 1121448002578 Nitrogen fixation protein of unknown function; Region: Nif11; cl06756 1121448002579 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 1121448002580 EamA-like transporter family; Region: EamA; pfam00892 1121448002581 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1121448002582 Helix-turn-helix domain; Region: HTH_18; pfam12833 1121448002583 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1121448002584 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1121448002585 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 1121448002586 putative ADP-binding pocket [chemical binding]; other site 1121448002587 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1121448002588 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 1121448002589 putative ADP-binding pocket [chemical binding]; other site 1121448002590 Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968 1121448002591 Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437 1121448002592 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1121448002593 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 1121448002594 spermidine synthase; Provisional; Region: PRK03612 1121448002595 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1121448002596 S-adenosylmethionine binding site [chemical binding]; other site 1121448002597 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; pfam02592 1121448002598 Domain of unknown function (DUF4178); Region: DUF4178; pfam13785 1121448002599 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 1121448002600 PAS domain S-box; Region: sensory_box; TIGR00229 1121448002601 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1121448002602 putative active site [active] 1121448002603 heme pocket [chemical binding]; other site 1121448002604 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1121448002605 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121448002606 putative active site [active] 1121448002607 heme pocket [chemical binding]; other site 1121448002608 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1121448002609 dimer interface [polypeptide binding]; other site 1121448002610 phosphorylation site [posttranslational modification] 1121448002611 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121448002612 ATP binding site [chemical binding]; other site 1121448002613 Mg2+ binding site [ion binding]; other site 1121448002614 G-X-G motif; other site 1121448002615 HDOD domain; Region: HDOD; pfam08668 1121448002616 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1121448002617 Zn2+ binding site [ion binding]; other site 1121448002618 Mg2+ binding site [ion binding]; other site 1121448002619 PAS domain; Region: PAS; smart00091 1121448002620 PAS fold; Region: PAS_4; pfam08448 1121448002621 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 1121448002622 Domain of unknown function (DUF4139); Region: DUF4139; pfam13598 1121448002623 murein hydrolase B; Provisional; Region: PRK10760; cl17906 1121448002624 Transglycosylase SLT domain; Region: SLT_2; pfam13406 1121448002625 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1121448002626 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1121448002627 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 1121448002628 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 1121448002629 active site 1121448002630 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 1121448002631 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1121448002632 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 1121448002633 putative FMN binding site [chemical binding]; other site 1121448002634 Predicted exonuclease [DNA replication, recombination, and repair]; Region: COG3359 1121448002635 RNase_H superfamily; Region: RNase_H_2; pfam13482 1121448002636 Response regulator receiver domain; Region: Response_reg; pfam00072 1121448002637 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121448002638 active site 1121448002639 phosphorylation site [posttranslational modification] 1121448002640 intermolecular recognition site; other site 1121448002641 dimerization interface [polypeptide binding]; other site 1121448002642 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1121448002643 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1121448002644 phosphorylation site [posttranslational modification] 1121448002645 dimer interface [polypeptide binding]; other site 1121448002646 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121448002647 ATP binding site [chemical binding]; other site 1121448002648 Mg2+ binding site [ion binding]; other site 1121448002649 G-X-G motif; other site 1121448002650 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 1121448002651 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121448002652 active site 1121448002653 phosphorylation site [posttranslational modification] 1121448002654 intermolecular recognition site; other site 1121448002655 dimerization interface [polypeptide binding]; other site 1121448002656 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1121448002657 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121448002658 PAS domain; Region: PAS_9; pfam13426 1121448002659 putative active site [active] 1121448002660 heme pocket [chemical binding]; other site 1121448002661 PAS domain S-box; Region: sensory_box; TIGR00229 1121448002662 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1121448002663 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121448002664 putative active site [active] 1121448002665 heme pocket [chemical binding]; other site 1121448002666 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1121448002667 dimer interface [polypeptide binding]; other site 1121448002668 phosphorylation site [posttranslational modification] 1121448002669 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121448002670 ATP binding site [chemical binding]; other site 1121448002671 Mg2+ binding site [ion binding]; other site 1121448002672 G-X-G motif; other site 1121448002673 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1121448002674 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121448002675 active site 1121448002676 phosphorylation site [posttranslational modification] 1121448002677 intermolecular recognition site; other site 1121448002678 dimerization interface [polypeptide binding]; other site 1121448002679 Response regulator receiver domain; Region: Response_reg; pfam00072 1121448002680 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121448002681 active site 1121448002682 phosphorylation site [posttranslational modification] 1121448002683 intermolecular recognition site; other site 1121448002684 dimerization interface [polypeptide binding]; other site 1121448002685 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1121448002686 putative binding surface; other site 1121448002687 active site 1121448002688 arginine decarboxylase; Provisional; Region: PRK15029 1121448002689 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121448002690 active site 1121448002691 phosphorylation site [posttranslational modification] 1121448002692 intermolecular recognition site; other site 1121448002693 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 1121448002694 homodimer interface [polypeptide binding]; other site 1121448002695 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1121448002696 catalytic residue [active] 1121448002697 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1121448002698 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 1121448002699 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1121448002700 active site 1121448002701 motif I; other site 1121448002702 motif II; other site 1121448002703 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 1121448002704 Response regulator receiver domain; Region: Response_reg; pfam00072 1121448002705 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121448002706 active site 1121448002707 phosphorylation site [posttranslational modification] 1121448002708 intermolecular recognition site; other site 1121448002709 dimerization interface [polypeptide binding]; other site 1121448002710 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 1121448002711 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 1121448002712 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1121448002713 putative binding surface; other site 1121448002714 active site 1121448002715 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121448002716 PAS domain; Region: PAS_9; pfam13426 1121448002717 putative active site [active] 1121448002718 heme pocket [chemical binding]; other site 1121448002719 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1121448002720 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1121448002721 metal binding site [ion binding]; metal-binding site 1121448002722 active site 1121448002723 I-site; other site 1121448002724 Peptidase C13 family; Region: Peptidase_C13; cl02159 1121448002725 Quinol:fumarate reductase (QFR) Type B subfamily, transmembrane subunit; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinone...; Region: QFR_TypeB_TM; cd00581 1121448002726 Iron-sulfur protein interface; other site 1121448002727 proximal heme binding site [chemical binding]; other site 1121448002728 distal heme binding site [chemical binding]; other site 1121448002729 dimer interface [polypeptide binding]; other site 1121448002730 fumarate reductase flavoprotein subunit; Provisional; Region: PRK08626 1121448002731 L-aspartate oxidase; Provisional; Region: PRK06175 1121448002732 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1121448002733 fumarate reductase iron-sulfur subunit; Provisional; Region: frdB; PRK13552 1121448002734 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1121448002735 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 1121448002736 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 1121448002737 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 1121448002738 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 1121448002739 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1121448002740 HlyD family secretion protein; Region: HlyD_3; pfam13437 1121448002741 Protein of unknown function (DUF3347); Region: DUF3347; pfam11827 1121448002742 Outer membrane efflux protein; Region: OEP; pfam02321 1121448002743 Outer membrane efflux protein; Region: OEP; pfam02321 1121448002744 polysaccharide export inner-membrane protein, BexC/CtrB/KpsE family; Region: BexC_CtrB_KpsE; TIGR01010 1121448002745 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1121448002746 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1121448002747 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 1121448002748 Walker A/P-loop; other site 1121448002749 ATP binding site [chemical binding]; other site 1121448002750 Q-loop/lid; other site 1121448002751 ABC transporter signature motif; other site 1121448002752 Walker B; other site 1121448002753 D-loop; other site 1121448002754 H-loop/switch region; other site 1121448002755 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1121448002756 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1121448002757 putative active site [active] 1121448002758 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1121448002759 active site 1121448002760 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1121448002761 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1121448002762 putative substrate translocation pore; other site 1121448002763 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08665 1121448002764 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 1121448002765 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 1121448002766 active site 1121448002767 dimer interface [polypeptide binding]; other site 1121448002768 effector binding site; other site 1121448002769 TSCPD domain; Region: TSCPD; pfam12637 1121448002770 cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673 1121448002771 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1121448002772 Walker A/P-loop; other site 1121448002773 ATP binding site [chemical binding]; other site 1121448002774 Q-loop/lid; other site 1121448002775 ABC transporter signature motif; other site 1121448002776 Walker B; other site 1121448002777 D-loop; other site 1121448002778 H-loop/switch region; other site 1121448002779 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 1121448002780 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 1121448002781 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 1121448002782 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1121448002783 S-adenosylmethionine binding site [chemical binding]; other site 1121448002784 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 1121448002785 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1121448002786 dimer interface [polypeptide binding]; other site 1121448002787 motif 1; other site 1121448002788 active site 1121448002789 motif 2; other site 1121448002790 motif 3; other site 1121448002791 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1121448002792 anticodon binding site; other site 1121448002793 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1121448002794 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1121448002795 dimer interface [polypeptide binding]; other site 1121448002796 anticodon binding site; other site 1121448002797 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1121448002798 homodimer interface [polypeptide binding]; other site 1121448002799 motif 1; other site 1121448002800 active site 1121448002801 motif 2; other site 1121448002802 GAD domain; Region: GAD; pfam02938 1121448002803 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1121448002804 active site 1121448002805 motif 3; other site 1121448002806 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1121448002807 active site 1121448002808 catalytic residues [active] 1121448002809 metal binding site [ion binding]; metal-binding site 1121448002810 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1121448002811 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1121448002812 putative active site [active] 1121448002813 substrate binding site [chemical binding]; other site 1121448002814 putative cosubstrate binding site; other site 1121448002815 catalytic site [active] 1121448002816 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1121448002817 substrate binding site [chemical binding]; other site 1121448002818 Protein of unknown function DUF116; Region: DUF116; pfam01976 1121448002819 NusB family; Region: NusB; pfam01029 1121448002820 putative RNA binding site [nucleotide binding]; other site 1121448002821 ribosomal RNA small subunit methyltransferase RsmB; Region: rsmB; TIGR00563 1121448002822 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1121448002823 S-adenosylmethionine binding site [chemical binding]; other site 1121448002824 Domain of unknown function (DUF1992); Region: DUF1992; cl08096 1121448002825 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 1121448002826 mce related protein; Region: MCE; pfam02470 1121448002827 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 1121448002828 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 1121448002829 Walker A/P-loop; other site 1121448002830 ATP binding site [chemical binding]; other site 1121448002831 Q-loop/lid; other site 1121448002832 ABC transporter signature motif; other site 1121448002833 Walker B; other site 1121448002834 D-loop; other site 1121448002835 H-loop/switch region; other site 1121448002836 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1121448002837 Permease; Region: Permease; pfam02405 1121448002838 ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaE; COG2870 1121448002839 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 1121448002840 putative ribose interaction site [chemical binding]; other site 1121448002841 putative ADP binding site [chemical binding]; other site 1121448002842 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 1121448002843 ParB-like nuclease domain; Region: ParB; smart00470 1121448002844 KorB domain; Region: KorB; pfam08535 1121448002845 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1121448002846 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1121448002847 P-loop; other site 1121448002848 Magnesium ion binding site [ion binding]; other site 1121448002849 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1121448002850 Magnesium ion binding site [ion binding]; other site 1121448002851 XXXCH domain; Region: XXXCH_domain; TIGR04358 1121448002852 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1121448002853 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 1121448002854 putative NAD(P) binding site [chemical binding]; other site 1121448002855 active site 1121448002856 putative substrate binding site [chemical binding]; other site 1121448002857 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 1121448002858 Flavoprotein; Region: Flavoprotein; pfam02441 1121448002859 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 1121448002860 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 1121448002861 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 1121448002862 Ferredoxin [Energy production and conversion]; Region: COG1146 1121448002863 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 1121448002864 2-ketoisovalerate ferredoxin reductase; Validated; Region: PRK07119 1121448002865 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 1121448002866 dimer interface [polypeptide binding]; other site 1121448002867 PYR/PP interface [polypeptide binding]; other site 1121448002868 TPP binding site [chemical binding]; other site 1121448002869 substrate binding site [chemical binding]; other site 1121448002870 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit [Energy production and conversion]; Region: PorB; COG1013 1121448002871 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 1121448002872 TPP-binding site [chemical binding]; other site 1121448002873 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 1121448002874 2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537 1121448002875 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 1121448002876 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1121448002877 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1121448002878 NAD(P) binding site [chemical binding]; other site 1121448002879 shikimate binding site; other site 1121448002880 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 1121448002881 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1121448002882 ATP binding site [chemical binding]; other site 1121448002883 putative Mg++ binding site [ion binding]; other site 1121448002884 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1121448002885 nucleotide binding region [chemical binding]; other site 1121448002886 ATP-binding site [chemical binding]; other site 1121448002887 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 1121448002888 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 1121448002889 active site 1121448002890 substrate binding site [chemical binding]; other site 1121448002891 catalytic site [active] 1121448002892 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1121448002893 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121448002894 active site 1121448002895 phosphorylation site [posttranslational modification] 1121448002896 intermolecular recognition site; other site 1121448002897 dimerization interface [polypeptide binding]; other site 1121448002898 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1121448002899 Walker A motif; other site 1121448002900 ATP binding site [chemical binding]; other site 1121448002901 Walker B motif; other site 1121448002902 arginine finger; other site 1121448002903 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1121448002904 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1121448002905 dimer interface [polypeptide binding]; other site 1121448002906 phosphorylation site [posttranslational modification] 1121448002907 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121448002908 ATP binding site [chemical binding]; other site 1121448002909 Mg2+ binding site [ion binding]; other site 1121448002910 G-X-G motif; other site 1121448002911 aspartate aminotransferase; Provisional; Region: PRK05764 1121448002912 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1121448002913 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1121448002914 homodimer interface [polypeptide binding]; other site 1121448002915 catalytic residue [active] 1121448002916 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 1121448002917 GTPase Era; Reviewed; Region: era; PRK00089 1121448002918 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1121448002919 G1 box; other site 1121448002920 GTP/Mg2+ binding site [chemical binding]; other site 1121448002921 Switch I region; other site 1121448002922 G2 box; other site 1121448002923 Switch II region; other site 1121448002924 G3 box; other site 1121448002925 G4 box; other site 1121448002926 G5 box; other site 1121448002927 KH domain; Region: KH_2; pfam07650 1121448002928 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 1121448002929 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1121448002930 catalytic residue [active] 1121448002931 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 1121448002932 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 1121448002933 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 1121448002934 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1121448002935 ligand binding site [chemical binding]; other site 1121448002936 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1121448002937 ligand binding site [chemical binding]; other site 1121448002938 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 1121448002939 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 1121448002940 flagellar biosynthetic protein FliO; Region: FliO_TIGR; TIGR03500 1121448002941 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 1121448002942 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 1121448002943 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 1121448002944 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1121448002945 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 1121448002946 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 1121448002947 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1121448002948 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1121448002949 catalytic residue [active] 1121448002950 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1121448002951 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1121448002952 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1121448002953 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 1121448002954 Acylphosphatase; Region: Acylphosphatase; cl00551 1121448002955 HypF finger; Region: zf-HYPF; pfam07503 1121448002956 HypF finger; Region: zf-HYPF; pfam07503 1121448002957 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 1121448002958 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 1121448002959 Transglycosylase; Region: Transgly; pfam00912 1121448002960 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1121448002961 RNA binding site [nucleotide binding]; other site 1121448002962 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1121448002963 PBP superfamily domain; Region: PBP_like_2; pfam12849 1121448002964 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 1121448002965 DNA binding residues [nucleotide binding] 1121448002966 MoeA_like. This domain is similar to a domain found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. There this domain is presumed to bind molybdopterin. The exact function of this subgroup is...; Region: MoeA_like; cd03522 1121448002967 putative MPT binding site; other site 1121448002968 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1121448002969 selenium-dependent molybdenum hydroxylase 1; Region: Se_dep_Molyb_1; TIGR03311 1121448002970 catalytic loop [active] 1121448002971 iron binding site [ion binding]; other site 1121448002972 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1121448002973 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; pfam01315 1121448002974 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1121448002975 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 1121448002976 FMN binding site [chemical binding]; other site 1121448002977 dimer interface [polypeptide binding]; other site 1121448002978 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 1121448002979 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1121448002980 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1121448002981 Methyltransferase domain; Region: Methyltransf_11; pfam08241 1121448002982 S-adenosylmethionine binding site [chemical binding]; other site 1121448002983 Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; pfam09719 1121448002984 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1121448002985 FeS/SAM binding site; other site 1121448002986 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG1964 1121448002987 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 1121448002988 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1121448002989 acyl-activating enzyme (AAE) consensus motif; other site 1121448002990 active site 1121448002991 AMP binding site [chemical binding]; other site 1121448002992 CoA binding site [chemical binding]; other site 1121448002993 xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964 1121448002994 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 1121448002995 XdhC Rossmann domain; Region: XdhC_C; pfam13478 1121448002996 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1121448002997 catalytic core [active] 1121448002998 HEAT repeats; Region: HEAT_2; pfam13646 1121448002999 Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cl02500 1121448003000 HEAT repeats; Region: HEAT_2; pfam13646 1121448003001 protein binding surface [polypeptide binding]; other site 1121448003002 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1121448003003 non-specific DNA binding site [nucleotide binding]; other site 1121448003004 salt bridge; other site 1121448003005 sequence-specific DNA binding site [nucleotide binding]; other site 1121448003006 Integrase core domain; Region: rve; pfam00665 1121448003007 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 1121448003008 AAA domain; Region: AAA_22; pfam13401 1121448003009 Protein of unknown function (DUF3164); Region: DUF3164; pfam11363 1121448003010 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1121448003011 IHF - DNA interface [nucleotide binding]; other site 1121448003012 IHF dimer interface [polypeptide binding]; other site 1121448003013 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 1121448003014 Protein of unknown function (DUF1018); Region: DUF1018; pfam06252 1121448003015 Homeodomain-like domain; Region: HTH_23; pfam13384 1121448003016 Uncharacterized conserved protein [Function unknown]; Region: COG4748 1121448003017 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 1121448003018 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 1121448003019 mismatch recognition site; other site 1121448003020 additional DNA contacts [nucleotide binding]; other site 1121448003021 active site 1121448003022 zinc binding site [ion binding]; other site 1121448003023 DNA intercalation site [nucleotide binding]; other site 1121448003024 C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145 1121448003025 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1121448003026 cofactor binding site; other site 1121448003027 DNA binding site [nucleotide binding] 1121448003028 substrate interaction site [chemical binding]; other site 1121448003029 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1121448003030 Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838 1121448003031 Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374 1121448003032 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 1121448003033 Protein of unknown function (DUF2730); Region: DUF2730; pfam10805 1121448003034 Protein of unknown function (DUF3486); Region: DUF3486; pfam11985 1121448003035 Mu-like prophage FluMu protein gp28 [General function prediction only]; Region: COG4373 1121448003036 Terminase-like family; Region: Terminase_6; pfam03237 1121448003037 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 1121448003038 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 1121448003039 Protein of unknown function (DUF1320); Region: DUF1320; cl01818 1121448003040 Phage virion morphogenesis family; Region: Phage_tail_S; cl02089 1121448003041 Domain of unknown function (DUF1789); Region: DUF1789; pfam08748 1121448003042 Phage related hypothetical protein (DUF1799); Region: DUF1799; pfam08809 1121448003043 Domain of unknown function (DUF1833); Region: DUF1833; pfam08875 1121448003044 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 1121448003045 DNA methylase; Region: N6_N4_Mtase; pfam01555 1121448003046 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 1121448003047 Coenzyme A binding pocket [chemical binding]; other site 1121448003048 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1121448003049 Thioredoxin (TRX)-Glutaredoxin (GRX)-like family; composed of archaeal and bacterial proteins that show similarity to both TRX and GRX, including the C-terminal TRX-fold subdomain of Pyrococcus furiosus protein disulfide oxidoreductase (PfPDO). All...; Region: TRX_GRX_like; cd02973 1121448003050 catalytic residues [active] 1121448003051 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1121448003052 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1121448003053 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1121448003054 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1121448003055 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1121448003056 motif II; other site 1121448003057 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1121448003058 homotrimer interaction site [polypeptide binding]; other site 1121448003059 putative active site [active] 1121448003060 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1121448003061 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1121448003062 ligand binding site [chemical binding]; other site 1121448003063 flexible hinge region; other site 1121448003064 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1121448003065 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1121448003066 active site 1121448003067 ATP binding site [chemical binding]; other site 1121448003068 substrate binding site [chemical binding]; other site 1121448003069 activation loop (A-loop); other site 1121448003070 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 1121448003071 AzlC protein; Region: AzlC; pfam03591 1121448003072 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1121448003073 dimerization interface [polypeptide binding]; other site 1121448003074 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121448003075 PAS domain; Region: PAS_9; pfam13426 1121448003076 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1121448003077 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1121448003078 dimer interface [polypeptide binding]; other site 1121448003079 hypothetical protein; Reviewed; Region: PRK09588 1121448003080 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 1121448003081 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1121448003082 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1121448003083 metal binding site [ion binding]; metal-binding site 1121448003084 active site 1121448003085 I-site; other site 1121448003086 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1121448003087 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121448003088 active site 1121448003089 phosphorylation site [posttranslational modification] 1121448003090 intermolecular recognition site; other site 1121448003091 dimerization interface [polypeptide binding]; other site 1121448003092 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1121448003093 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1121448003094 metal binding site [ion binding]; metal-binding site 1121448003095 active site 1121448003096 I-site; other site 1121448003097 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121448003098 Response regulator receiver domain; Region: Response_reg; pfam00072 1121448003099 active site 1121448003100 phosphorylation site [posttranslational modification] 1121448003101 intermolecular recognition site; other site 1121448003102 dimerization interface [polypeptide binding]; other site 1121448003103 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1121448003104 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121448003105 active site 1121448003106 phosphorylation site [posttranslational modification] 1121448003107 intermolecular recognition site; other site 1121448003108 dimerization interface [polypeptide binding]; other site 1121448003109 Protein of unknown function (DUF3124); Region: DUF3124; pfam11322 1121448003110 Cache domain; Region: Cache_1; pfam02743 1121448003111 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1121448003112 dimerization interface [polypeptide binding]; other site 1121448003113 PAS domain; Region: PAS_9; pfam13426 1121448003114 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121448003115 putative active site [active] 1121448003116 heme pocket [chemical binding]; other site 1121448003117 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1121448003118 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1121448003119 dimer interface [polypeptide binding]; other site 1121448003120 putative CheW interface [polypeptide binding]; other site 1121448003121 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1121448003122 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1121448003123 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1121448003124 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1121448003125 AAA domain; Region: AAA_32; pfam13654 1121448003126 Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067 1121448003127 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1121448003128 metal binding site 2 [ion binding]; metal-binding site 1121448003129 putative DNA binding helix; other site 1121448003130 metal binding site 1 [ion binding]; metal-binding site 1121448003131 dimer interface [polypeptide binding]; other site 1121448003132 structural Zn2+ binding site [ion binding]; other site 1121448003133 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 1121448003134 Curli production assembly/transport component CsgG; Region: CsgG; cl17434 1121448003135 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 1121448003136 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 1121448003137 dimer interface [polypeptide binding]; other site 1121448003138 PYR/PP interface [polypeptide binding]; other site 1121448003139 TPP binding site [chemical binding]; other site 1121448003140 substrate binding site [chemical binding]; other site 1121448003141 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 1121448003142 Domain of unknown function; Region: EKR; pfam10371 1121448003143 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1121448003144 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 1121448003145 TPP-binding site [chemical binding]; other site 1121448003146 dimer interface [polypeptide binding]; other site 1121448003147 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1121448003148 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 1121448003149 transmembrane helices; other site 1121448003150 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1121448003151 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121448003152 active site 1121448003153 phosphorylation site [posttranslational modification] 1121448003154 intermolecular recognition site; other site 1121448003155 dimerization interface [polypeptide binding]; other site 1121448003156 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1121448003157 Walker A motif; other site 1121448003158 ATP binding site [chemical binding]; other site 1121448003159 Walker B motif; other site 1121448003160 arginine finger; other site 1121448003161 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 1121448003162 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1121448003163 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1121448003164 substrate binding pocket [chemical binding]; other site 1121448003165 membrane-bound complex binding site; other site 1121448003166 hinge residues; other site 1121448003167 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121448003168 ATP binding site [chemical binding]; other site 1121448003169 Mg2+ binding site [ion binding]; other site 1121448003170 G-X-G motif; other site 1121448003171 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 1121448003172 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121448003173 PAS fold; Region: PAS_3; pfam08447 1121448003174 putative active site [active] 1121448003175 heme pocket [chemical binding]; other site 1121448003176 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121448003177 PAS fold; Region: PAS_3; pfam08447 1121448003178 putative active site [active] 1121448003179 heme pocket [chemical binding]; other site 1121448003180 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121448003181 PAS domain; Region: PAS_9; pfam13426 1121448003182 putative active site [active] 1121448003183 heme pocket [chemical binding]; other site 1121448003184 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 1121448003185 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1121448003186 Protein of unknown function (DUF1566); Region: DUF1566; pfam07603 1121448003187 Protein of unknown function (DUF1566); Region: DUF1566; pfam07603 1121448003188 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 1121448003189 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051 1121448003190 EF-hand domain pair; Region: EF_hand_5; pfam13499 1121448003191 Ca2+ binding site [ion binding]; other site 1121448003192 Response regulator receiver domain; Region: Response_reg; pfam00072 1121448003193 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121448003194 active site 1121448003195 phosphorylation site [posttranslational modification] 1121448003196 intermolecular recognition site; other site 1121448003197 dimerization interface [polypeptide binding]; other site 1121448003198 PAS domain S-box; Region: sensory_box; TIGR00229 1121448003199 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121448003200 putative active site [active] 1121448003201 heme pocket [chemical binding]; other site 1121448003202 PAS fold; Region: PAS_4; pfam08448 1121448003203 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1121448003204 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1121448003205 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1121448003206 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 1121448003207 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1121448003208 Ligand Binding Site [chemical binding]; other site 1121448003209 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1121448003210 Ligand Binding Site [chemical binding]; other site 1121448003211 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1121448003212 Ligand Binding Site [chemical binding]; other site 1121448003213 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1121448003214 Zn2+ binding site [ion binding]; other site 1121448003215 Mg2+ binding site [ion binding]; other site 1121448003216 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1121448003217 putative active site [active] 1121448003218 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1121448003219 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1121448003220 binding surface 1121448003221 TPR motif; other site 1121448003222 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1121448003223 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1121448003224 binding surface 1121448003225 TPR motif; other site 1121448003226 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1121448003227 Flagellin N-methylase; Region: FliB; pfam03692 1121448003228 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 1121448003229 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 1121448003230 PAS domain S-box; Region: sensory_box; TIGR00229 1121448003231 PAS domain; Region: PAS; smart00091 1121448003232 putative active site [active] 1121448003233 heme pocket [chemical binding]; other site 1121448003234 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1121448003235 Histidine kinase; Region: HisKA_2; pfam07568 1121448003236 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121448003237 ATP binding site [chemical binding]; other site 1121448003238 Mg2+ binding site [ion binding]; other site 1121448003239 G-X-G motif; other site 1121448003240 PAS domain; Region: PAS_9; pfam13426 1121448003241 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1121448003242 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1121448003243 metal binding site [ion binding]; metal-binding site 1121448003244 active site 1121448003245 I-site; other site 1121448003246 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 1121448003247 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1121448003248 active site 1121448003249 Riboflavin kinase; Region: Flavokinase; pfam01687 1121448003250 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 1121448003251 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1121448003252 Cl- selectivity filter; other site 1121448003253 Cl- binding residues [ion binding]; other site 1121448003254 pore gating glutamate residue; other site 1121448003255 dimer interface [polypeptide binding]; other site 1121448003256 FOG: CBS domain [General function prediction only]; Region: COG0517 1121448003257 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc2; cd04613 1121448003258 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 1121448003259 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 1121448003260 putative active site; other site 1121448003261 catalytic residue [active] 1121448003262 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 1121448003263 Family description; Region: VCBS; pfam13517 1121448003264 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1121448003265 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1121448003266 TM-ABC transporter signature motif; other site 1121448003267 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1121448003268 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1121448003269 TM-ABC transporter signature motif; other site 1121448003270 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1121448003271 Type I periplasmic binding component of ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in uptake of amino acids; Region: PBP1_ABC-type_HAAT_like; cd06333 1121448003272 putative ligand binding site [chemical binding]; other site 1121448003273 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1121448003274 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1121448003275 active site 1121448003276 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 1121448003277 dimer interface [polypeptide binding]; other site 1121448003278 putative tRNA-binding site [nucleotide binding]; other site 1121448003279 Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653 1121448003280 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 1121448003281 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 1121448003282 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 1121448003283 active site 1121448003284 NAD binding site [chemical binding]; other site 1121448003285 metal binding site [ion binding]; metal-binding site 1121448003286 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1121448003287 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 1121448003288 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 1121448003289 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1121448003290 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1121448003291 Predicted transcriptional regulators [Transcription]; Region: COG1733 1121448003292 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 1121448003293 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 1121448003294 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 1121448003295 active site 1121448003296 NAD binding site [chemical binding]; other site 1121448003297 metal binding site [ion binding]; metal-binding site 1121448003298 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1121448003299 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121448003300 putative active site [active] 1121448003301 heme pocket [chemical binding]; other site 1121448003302 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1121448003303 dimer interface [polypeptide binding]; other site 1121448003304 phosphorylation site [posttranslational modification] 1121448003305 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121448003306 ATP binding site [chemical binding]; other site 1121448003307 Mg2+ binding site [ion binding]; other site 1121448003308 G-X-G motif; other site 1121448003309 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1121448003310 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121448003311 active site 1121448003312 phosphorylation site [posttranslational modification] 1121448003313 intermolecular recognition site; other site 1121448003314 dimerization interface [polypeptide binding]; other site 1121448003315 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1121448003316 Walker A motif; other site 1121448003317 ATP binding site [chemical binding]; other site 1121448003318 Walker B motif; other site 1121448003319 arginine finger; other site 1121448003320 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1121448003321 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 1121448003322 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 1121448003323 dimer interface [polypeptide binding]; other site 1121448003324 active site 1121448003325 metal binding site [ion binding]; metal-binding site 1121448003326 Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414 1121448003327 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730 1121448003328 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 1121448003329 Aspartate oxidase [Coenzyme metabolism]; Region: NadB; COG0029 1121448003330 L-aspartate oxidase; Provisional; Region: PRK06175 1121448003331 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1121448003332 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 1121448003333 catalytic residues [active] 1121448003334 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1121448003335 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cl01482 1121448003336 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1121448003337 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121448003338 putative active site [active] 1121448003339 heme pocket [chemical binding]; other site 1121448003340 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1121448003341 phosphorylation site [posttranslational modification] 1121448003342 dimer interface [polypeptide binding]; other site 1121448003343 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121448003344 ATP binding site [chemical binding]; other site 1121448003345 G-X-G motif; other site 1121448003346 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1121448003347 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121448003348 active site 1121448003349 phosphorylation site [posttranslational modification] 1121448003350 intermolecular recognition site; other site 1121448003351 dimerization interface [polypeptide binding]; other site 1121448003352 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1121448003353 Walker A motif; other site 1121448003354 ATP binding site [chemical binding]; other site 1121448003355 Walker B motif; other site 1121448003356 arginine finger; other site 1121448003357 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1121448003358 Domain of unknown function (DUF3391); Region: DUF3391; pfam11871 1121448003359 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 1121448003360 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1121448003361 Zn2+ binding site [ion binding]; other site 1121448003362 Mg2+ binding site [ion binding]; other site 1121448003363 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121448003364 Response regulator receiver domain; Region: Response_reg; pfam00072 1121448003365 active site 1121448003366 phosphorylation site [posttranslational modification] 1121448003367 intermolecular recognition site; other site 1121448003368 dimerization interface [polypeptide binding]; other site 1121448003369 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1121448003370 dimer interface [polypeptide binding]; other site 1121448003371 phosphorylation site [posttranslational modification] 1121448003372 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121448003373 ATP binding site [chemical binding]; other site 1121448003374 Mg2+ binding site [ion binding]; other site 1121448003375 G-X-G motif; other site 1121448003376 Response regulator receiver domain; Region: Response_reg; pfam00072 1121448003377 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121448003378 active site 1121448003379 phosphorylation site [posttranslational modification] 1121448003380 intermolecular recognition site; other site 1121448003381 dimerization interface [polypeptide binding]; other site 1121448003382 PAS domain; Region: PAS; smart00091 1121448003383 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1121448003384 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121448003385 putative active site [active] 1121448003386 heme pocket [chemical binding]; other site 1121448003387 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1121448003388 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1121448003389 dimer interface [polypeptide binding]; other site 1121448003390 phosphorylation site [posttranslational modification] 1121448003391 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121448003392 ATP binding site [chemical binding]; other site 1121448003393 Mg2+ binding site [ion binding]; other site 1121448003394 G-X-G motif; other site 1121448003395 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1121448003396 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121448003397 active site 1121448003398 phosphorylation site [posttranslational modification] 1121448003399 intermolecular recognition site; other site 1121448003400 dimerization interface [polypeptide binding]; other site 1121448003401 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1121448003402 Walker A motif; other site 1121448003403 ATP binding site [chemical binding]; other site 1121448003404 Walker B motif; other site 1121448003405 arginine finger; other site 1121448003406 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1121448003407 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1121448003408 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1121448003409 substrate binding pocket [chemical binding]; other site 1121448003410 membrane-bound complex binding site; other site 1121448003411 hinge residues; other site 1121448003412 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1121448003413 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121448003414 putative active site [active] 1121448003415 heme pocket [chemical binding]; other site 1121448003416 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1121448003417 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1121448003418 dimer interface [polypeptide binding]; other site 1121448003419 phosphorylation site [posttranslational modification] 1121448003420 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121448003421 ATP binding site [chemical binding]; other site 1121448003422 Mg2+ binding site [ion binding]; other site 1121448003423 G-X-G motif; other site 1121448003424 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 1121448003425 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1121448003426 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121448003427 active site 1121448003428 phosphorylation site [posttranslational modification] 1121448003429 intermolecular recognition site; other site 1121448003430 dimerization interface [polypeptide binding]; other site 1121448003431 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 1121448003432 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 1121448003433 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1121448003434 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 1121448003435 FMN binding site [chemical binding]; other site 1121448003436 active site 1121448003437 catalytic residues [active] 1121448003438 substrate binding site [chemical binding]; other site 1121448003439 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 1121448003440 RNA polymerase sigma factor, FliA/WhiG family; Region: FliA_WhiG; TIGR02479 1121448003441 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1121448003442 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1121448003443 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1121448003444 DNA binding residues [nucleotide binding] 1121448003445 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 1121448003446 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 1121448003447 P-loop; other site 1121448003448 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 1121448003449 SRP54-type protein, GTPase domain; Region: SRP54; smart00962 1121448003450 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 1121448003451 FHIPEP family; Region: FHIPEP; pfam00771 1121448003452 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 1121448003453 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 1121448003454 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 1121448003455 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 1121448003456 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1121448003457 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 1121448003458 NAD(P) binding site [chemical binding]; other site 1121448003459 homodimer interface [polypeptide binding]; other site 1121448003460 substrate binding site [chemical binding]; other site 1121448003461 active site 1121448003462 aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181 1121448003463 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1121448003464 inhibitor-cofactor binding pocket; inhibition site 1121448003465 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1121448003466 catalytic residue [active] 1121448003467 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 1121448003468 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 1121448003469 putative trimer interface [polypeptide binding]; other site 1121448003470 putative CoA binding site [chemical binding]; other site 1121448003471 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1121448003472 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1121448003473 Ligand Binding Site [chemical binding]; other site 1121448003474 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1121448003475 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1121448003476 Walker A/P-loop; other site 1121448003477 ATP binding site [chemical binding]; other site 1121448003478 Q-loop/lid; other site 1121448003479 ABC transporter signature motif; other site 1121448003480 Walker B; other site 1121448003481 D-loop; other site 1121448003482 H-loop/switch region; other site 1121448003483 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1121448003484 TM-ABC transporter signature motif; other site 1121448003485 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1121448003486 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1121448003487 TM-ABC transporter signature motif; other site 1121448003488 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1121448003489 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 1121448003490 dimerization interface [polypeptide binding]; other site 1121448003491 ligand binding site [chemical binding]; other site 1121448003492 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1121448003493 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1121448003494 Walker A/P-loop; other site 1121448003495 ATP binding site [chemical binding]; other site 1121448003496 Q-loop/lid; other site 1121448003497 ABC transporter signature motif; other site 1121448003498 Walker B; other site 1121448003499 D-loop; other site 1121448003500 H-loop/switch region; other site 1121448003501 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1121448003502 EamA-like transporter family; Region: EamA; pfam00892 1121448003503 EamA-like transporter family; Region: EamA; pfam00892 1121448003504 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 1121448003505 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 1121448003506 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 1121448003507 dimerization interface [polypeptide binding]; other site 1121448003508 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 1121448003509 ATP binding site [chemical binding]; other site 1121448003510 atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245 1121448003511 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1121448003512 putative NAD(P) binding site [chemical binding]; other site 1121448003513 putative active site [active] 1121448003514 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 1121448003515 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 1121448003516 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1121448003517 molybdopterin cofactor binding site; other site 1121448003518 menaquinone biosynthesis decarboxylase, SCO4490 family; Region: mena_SCO4490; TIGR03701 1121448003519 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 1121448003520 Flavoprotein; Region: Flavoprotein; pfam02441 1121448003521 Adenosylhomocysteinase; Provisional; Region: PTZ00075 1121448003522 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 1121448003523 homotetramer interface [polypeptide binding]; other site 1121448003524 ligand binding site [chemical binding]; other site 1121448003525 catalytic site [active] 1121448003526 NAD binding site [chemical binding]; other site 1121448003527 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1121448003528 dimerization interface [polypeptide binding]; other site 1121448003529 putative DNA binding site [nucleotide binding]; other site 1121448003530 putative Zn2+ binding site [ion binding]; other site 1121448003531 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1121448003532 Protein of unknown function (DUF721); Region: DUF721; pfam05258 1121448003533 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1121448003534 DNA binding site [nucleotide binding] 1121448003535 active site 1121448003536 Int/Topo IB signature motif; other site 1121448003537 catalytic residues [active] 1121448003538 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 1121448003539 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1121448003540 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1121448003541 metal binding site [ion binding]; metal-binding site 1121448003542 active site 1121448003543 I-site; other site 1121448003544 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1121448003545 Beta-lactamase; Region: Beta-lactamase; pfam00144 1121448003546 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1121448003547 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1121448003548 DNA binding residues [nucleotide binding] 1121448003549 dimerization interface [polypeptide binding]; other site 1121448003550 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1121448003551 active site residue [active] 1121448003552 Protein of unknown function (DUF805); Region: DUF805; pfam05656 1121448003553 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1121448003554 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1121448003555 S-adenosylmethionine binding site [chemical binding]; other site 1121448003556 Predicted membrane protein [Function unknown]; Region: COG2860 1121448003557 UPF0126 domain; Region: UPF0126; pfam03458 1121448003558 UPF0126 domain; Region: UPF0126; pfam03458 1121448003559 Cache domain; Region: Cache_1; pfam02743 1121448003560 HAMP domain; Region: HAMP; pfam00672 1121448003561 PAS domain; Region: PAS_9; pfam13426 1121448003562 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1121448003563 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1121448003564 dimer interface [polypeptide binding]; other site 1121448003565 phosphorylation site [posttranslational modification] 1121448003566 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121448003567 ATP binding site [chemical binding]; other site 1121448003568 Mg2+ binding site [ion binding]; other site 1121448003569 G-X-G motif; other site 1121448003570 Response regulator receiver domain; Region: Response_reg; pfam00072 1121448003571 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121448003572 active site 1121448003573 phosphorylation site [posttranslational modification] 1121448003574 intermolecular recognition site; other site 1121448003575 dimerization interface [polypeptide binding]; other site 1121448003576 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 1121448003577 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1121448003578 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1121448003579 Coenzyme A binding pocket [chemical binding]; other site 1121448003580 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 1121448003581 cyclase homology domain; Region: CHD; cd07302 1121448003582 nucleotidyl binding site; other site 1121448003583 metal binding site [ion binding]; metal-binding site 1121448003584 dimer interface [polypeptide binding]; other site 1121448003585 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 1121448003586 DNA topoisomerase I; Validated; Region: PRK06599 1121448003587 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1121448003588 active site 1121448003589 interdomain interaction site; other site 1121448003590 putative metal-binding site [ion binding]; other site 1121448003591 nucleotide binding site [chemical binding]; other site 1121448003592 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1121448003593 domain I; other site 1121448003594 DNA binding groove [nucleotide binding] 1121448003595 phosphate binding site [ion binding]; other site 1121448003596 domain II; other site 1121448003597 domain III; other site 1121448003598 nucleotide binding site [chemical binding]; other site 1121448003599 catalytic site [active] 1121448003600 domain IV; other site 1121448003601 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1121448003602 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 1121448003603 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1121448003604 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1121448003605 ribulose-1,5-biphosphate synthetase; Provisional; Region: PRK04176 1121448003606 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1121448003607 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1121448003608 TPR motif; other site 1121448003609 binding surface 1121448003610 DNA gyrase subunit A; Validated; Region: PRK05560 1121448003611 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1121448003612 CAP-like domain; other site 1121448003613 active site 1121448003614 primary dimer interface [polypeptide binding]; other site 1121448003615 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1121448003616 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1121448003617 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1121448003618 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1121448003619 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1121448003620 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1121448003621 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 1121448003622 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121448003623 Mg2+ binding site [ion binding]; other site 1121448003624 G-X-G motif; other site 1121448003625 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1121448003626 anchoring element; other site 1121448003627 dimer interface [polypeptide binding]; other site 1121448003628 ATP binding site [chemical binding]; other site 1121448003629 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1121448003630 active site 1121448003631 putative metal-binding site [ion binding]; other site 1121448003632 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1121448003633 DNA polymerase III subunit beta; Provisional; Region: PRK14947 1121448003634 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1121448003635 putative DNA binding surface [nucleotide binding]; other site 1121448003636 dimer interface [polypeptide binding]; other site 1121448003637 beta-clamp/clamp loader binding surface; other site 1121448003638 beta-clamp/translesion DNA polymerase binding surface; other site 1121448003639 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 1121448003640 DnaA N-terminal domain; Region: DnaA_N; pfam11638 1121448003641 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1121448003642 Walker A motif; other site 1121448003643 ATP binding site [chemical binding]; other site 1121448003644 Walker B motif; other site 1121448003645 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1121448003646 DnaA box-binding interface [nucleotide binding]; other site 1121448003647 putative peptidase; Provisional; Region: PRK11649 1121448003648 Peptidase family M23; Region: Peptidase_M23; pfam01551 1121448003649 Uncharacterized conserved protein [Function unknown]; Region: COG4095 1121448003650 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 1121448003651 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 1121448003652 putative CheA interaction surface; other site 1121448003653 putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697 1121448003654 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121448003655 active site 1121448003656 phosphorylation site [posttranslational modification] 1121448003657 intermolecular recognition site; other site 1121448003658 dimerization interface [polypeptide binding]; other site 1121448003659 LytTr DNA-binding domain; Region: LytTR; smart00850 1121448003660 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 1121448003661 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 1121448003662 Histidine kinase; Region: His_kinase; pfam06580 1121448003663 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121448003664 ATP binding site [chemical binding]; other site 1121448003665 Mg2+ binding site [ion binding]; other site 1121448003666 G-X-G motif; other site 1121448003667 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 1121448003668 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 1121448003669 Carbon starvation protein CstA; Region: CstA; pfam02554 1121448003670 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 1121448003671 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 1121448003672 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1121448003673 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1121448003674 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1121448003675 catalytic residue [active] 1121448003676 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1121448003677 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1121448003678 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1121448003679 Tautomerase enzyme; Region: Tautomerase; pfam01361 1121448003680 active site 1 [active] 1121448003681 dimer interface [polypeptide binding]; other site 1121448003682 hexamer interface [polypeptide binding]; other site 1121448003683 active site 2 [active] 1121448003684 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 1121448003685 active site 1 [active] 1121448003686 dimer interface [polypeptide binding]; other site 1121448003687 hexamer interface [polypeptide binding]; other site 1121448003688 active site 2 [active] 1121448003689 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1121448003690 interface (dimer of trimers) [polypeptide binding]; other site 1121448003691 multifunctional aminopeptidase A; Provisional; Region: PRK00913 1121448003692 Substrate-binding/catalytic site; other site 1121448003693 Zn-binding sites [ion binding]; other site 1121448003694 Predicted acyl esterases [General function prediction only]; Region: COG2936 1121448003695 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1121448003696 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482 1121448003697 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1121448003698 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1121448003699 Metal-binding active site; metal-binding site 1121448003700 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1121448003701 SnoaL-like domain; Region: SnoaL_3; pfam13474 1121448003702 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1121448003703 active site 1121448003704 adenylosuccinate lyase; Provisional; Region: PRK07492 1121448003705 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 1121448003706 tetramer interface [polypeptide binding]; other site 1121448003707 active site 1121448003708 Adenylosuccinate lyase C-terminus; Region: ADSL_C; pfam10397 1121448003709 putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605 1121448003710 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 1121448003711 Ligand Binding Site [chemical binding]; other site 1121448003712 Domain of unknown function DUF39; Region: DUF39; pfam01837 1121448003713 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 1121448003714 Rubredoxin; Region: Rubredoxin; pfam00301 1121448003715 iron binding site [ion binding]; other site 1121448003716 helicase 45; Provisional; Region: PTZ00424 1121448003717 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1121448003718 ATP binding site [chemical binding]; other site 1121448003719 Mg++ binding site [ion binding]; other site 1121448003720 motif III; other site 1121448003721 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1121448003722 nucleotide binding region [chemical binding]; other site 1121448003723 ATP-binding site [chemical binding]; other site 1121448003724 Cache domain; Region: Cache_1; pfam02743 1121448003725 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1121448003726 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1121448003727 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1121448003728 metal binding site [ion binding]; metal-binding site 1121448003729 active site 1121448003730 I-site; other site 1121448003731 Predicted permease; Region: DUF318; cl17795 1121448003732 Domain of unknown function (DUF1980); Region: DUF1980; cl01492 1121448003733 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1121448003734 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1121448003735 dimerization interface 3.5A [polypeptide binding]; other site 1121448003736 active site 1121448003737 Uncharacterized conserved protein [Function unknown]; Region: COG3334 1121448003738 flagellar export protein FliJ; Region: flagell_FliJ; TIGR02473 1121448003739 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1121448003740 active site 1121448003741 Glycosyl transferase family 21; Region: Glyco_transf_21; pfam13506 1121448003742 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1121448003743 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1121448003744 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1121448003745 dimerization interface [polypeptide binding]; other site 1121448003746 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1121448003747 Type I periplasmic binding domain of uncharacterized extracellular ligand-binding proteins; Region: PBP1_STKc_like; cd06326 1121448003748 putative ligand binding site [chemical binding]; other site 1121448003749 Signal transduction histidine kinase, nitrate/nitrite-specific [Signal transduction mechanisms]; Region: NarQ; COG3850 1121448003750 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1121448003751 dimerization interface [polypeptide binding]; other site 1121448003752 PAS domain; Region: PAS; smart00091 1121448003753 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1121448003754 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1121448003755 dimer interface [polypeptide binding]; other site 1121448003756 phosphorylation site [posttranslational modification] 1121448003757 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121448003758 ATP binding site [chemical binding]; other site 1121448003759 Mg2+ binding site [ion binding]; other site 1121448003760 G-X-G motif; other site 1121448003761 Response regulator receiver domain; Region: Response_reg; pfam00072 1121448003762 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121448003763 active site 1121448003764 phosphorylation site [posttranslational modification] 1121448003765 intermolecular recognition site; other site 1121448003766 dimerization interface [polypeptide binding]; other site 1121448003767 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1121448003768 anti sigma factor interaction site; other site 1121448003769 regulatory phosphorylation site [posttranslational modification]; other site 1121448003770 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1121448003771 active site residue [active] 1121448003772 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1121448003773 EamA-like transporter family; Region: EamA; pfam00892 1121448003774 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1121448003775 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1121448003776 ligand binding site [chemical binding]; other site 1121448003777 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1121448003778 ligand binding site [chemical binding]; other site 1121448003779 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1121448003780 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1121448003781 ligand binding site [chemical binding]; other site 1121448003782 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 1121448003783 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 1121448003784 The MopB_Acetylene-hydratase CD contains acetylene hydratase (Ahy) and other related proteins. The acetylene hydratase of Pelobacter acetylenicus is a tungsten iron-sulfur protein involved in the fermentation of acetylene to ethanol and acetate. Members...; Region: MopB_Acetylene-hydratase; cd02759 1121448003785 putative [Fe4-S4] binding site [ion binding]; other site 1121448003786 putative molybdopterin cofactor binding site [chemical binding]; other site 1121448003787 The MopB_CT_Acetylene-hydratase CD contains acetylene hydratase (Ahy) and other related proteins. The acetylene hydratase of Pelobacter acetylenicus is a tungsten iron-sulfur protein involved in the fermentation of acetylene to ethanol and acetate. This...; Region: MopB_CT_Acetylene-hydratase; cd02781 1121448003788 putative molybdopterin cofactor binding site; other site 1121448003789 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1121448003790 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1121448003791 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1121448003792 Walker A/P-loop; other site 1121448003793 ATP binding site [chemical binding]; other site 1121448003794 Q-loop/lid; other site 1121448003795 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1121448003796 Q-loop/lid; other site 1121448003797 ABC transporter signature motif; other site 1121448003798 Walker B; other site 1121448003799 D-loop; other site 1121448003800 H-loop/switch region; other site 1121448003801 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1121448003802 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1121448003803 ligand binding site [chemical binding]; other site 1121448003804 flexible hinge region; other site 1121448003805 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1121448003806 anti sigma factor interaction site; other site 1121448003807 regulatory phosphorylation site [posttranslational modification]; other site 1121448003808 trehalose synthase; Region: treS_nterm; TIGR02456 1121448003809 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 1121448003810 active site 1121448003811 catalytic site [active] 1121448003812 Cyclo-malto-dextrinase C-terminal domain; Region: Cyc-maltodext_C; pfam10438 1121448003813 trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457 1121448003814 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 1121448003815 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1121448003816 Ligand Binding Site [chemical binding]; other site 1121448003817 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1121448003818 activation loop (A-loop); other site 1121448003819 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 1121448003820 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 1121448003821 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 1121448003822 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 1121448003823 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 1121448003824 Transglutaminase-like superfamily; Region: Transglut_core; cl17362 1121448003825 FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659 1121448003826 Nif-specific regulatory protein; Region: nifA; TIGR01817 1121448003827 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1121448003828 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1121448003829 Walker A motif; other site 1121448003830 ATP binding site [chemical binding]; other site 1121448003831 Walker B motif; other site 1121448003832 arginine finger; other site 1121448003833 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1121448003834 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1121448003835 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1121448003836 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1121448003837 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1121448003838 Uncharacterized conserved protein [Function unknown]; Region: COG2928 1121448003839 pantoate--beta-alanine ligase; Region: panC; TIGR00018 1121448003840 Pantoate-beta-alanine ligase; Region: PanC; cd00560 1121448003841 active site 1121448003842 ATP-binding site [chemical binding]; other site 1121448003843 pantoate-binding site; other site 1121448003844 HXXH motif; other site 1121448003845 Response regulator receiver domain; Region: Response_reg; pfam00072 1121448003846 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121448003847 active site 1121448003848 phosphorylation site [posttranslational modification] 1121448003849 intermolecular recognition site; other site 1121448003850 dimerization interface [polypeptide binding]; other site 1121448003851 photolyase PhrII; Region: phr2; TIGR00591 1121448003852 DNA photolyase; Region: DNA_photolyase; pfam00875 1121448003853 DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177 1121448003854 DNA polymerase III subunit delta'; Validated; Region: PRK08485 1121448003855 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1121448003856 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1121448003857 GDP-binding site [chemical binding]; other site 1121448003858 ACT binding site; other site 1121448003859 IMP binding site; other site 1121448003860 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 1121448003861 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 1121448003862 RNB domain; Region: RNB; pfam00773 1121448003863 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 1121448003864 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 1121448003865 NMT1/THI5 like; Region: NMT1; pfam09084 1121448003866 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1121448003867 substrate binding pocket [chemical binding]; other site 1121448003868 membrane-bound complex binding site; other site 1121448003869 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1121448003870 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1121448003871 putative active site [active] 1121448003872 heme pocket [chemical binding]; other site 1121448003873 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1121448003874 dimer interface [polypeptide binding]; other site 1121448003875 phosphorylation site [posttranslational modification] 1121448003876 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121448003877 ATP binding site [chemical binding]; other site 1121448003878 Mg2+ binding site [ion binding]; other site 1121448003879 G-X-G motif; other site 1121448003880 Response regulator receiver domain; Region: Response_reg; pfam00072 1121448003881 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121448003882 active site 1121448003883 phosphorylation site [posttranslational modification] 1121448003884 intermolecular recognition site; other site 1121448003885 dimerization interface [polypeptide binding]; other site 1121448003886 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1121448003887 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1121448003888 ABC-ATPase subunit interface; other site 1121448003889 dimer interface [polypeptide binding]; other site 1121448003890 putative PBP binding regions; other site 1121448003891 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 1121448003892 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1121448003893 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1121448003894 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1121448003895 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1121448003896 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 1121448003897 intersubunit interface [polypeptide binding]; other site 1121448003898 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121448003899 PAS domain; Region: PAS_9; pfam13426 1121448003900 putative active site [active] 1121448003901 heme pocket [chemical binding]; other site 1121448003902 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1121448003903 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121448003904 ATP binding site [chemical binding]; other site 1121448003905 Mg2+ binding site [ion binding]; other site 1121448003906 G-X-G motif; other site 1121448003907 Protein of unknown function, DUF599; Region: DUF599; cl01575 1121448003908 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1121448003909 putative catalytic site [active] 1121448003910 putative metal binding site [ion binding]; other site 1121448003911 putative phosphate binding site [ion binding]; other site 1121448003912 Response regulator receiver domain; Region: Response_reg; pfam00072 1121448003913 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121448003914 active site 1121448003915 phosphorylation site [posttranslational modification] 1121448003916 intermolecular recognition site; other site 1121448003917 dimerization interface [polypeptide binding]; other site 1121448003918 PAS domain S-box; Region: sensory_box; TIGR00229 1121448003919 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121448003920 putative active site [active] 1121448003921 heme pocket [chemical binding]; other site 1121448003922 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1121448003923 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1121448003924 metal binding site [ion binding]; metal-binding site 1121448003925 active site 1121448003926 I-site; other site 1121448003927 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1121448003928 Predicted inhibitor of MCP methylation, homolog of CheC [Cell motility and secretion]; Region: COG1406 1121448003929 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 1121448003930 HEAT repeats; Region: HEAT_2; pfam13646 1121448003931 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1121448003932 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121448003933 active site 1121448003934 phosphorylation site [posttranslational modification] 1121448003935 intermolecular recognition site; other site 1121448003936 dimerization interface [polypeptide binding]; other site 1121448003937 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 1121448003938 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121448003939 active site 1121448003940 phosphorylation site [posttranslational modification] 1121448003941 intermolecular recognition site; other site 1121448003942 dimerization interface [polypeptide binding]; other site 1121448003943 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG2; TIGR02495 1121448003944 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1121448003945 FeS/SAM binding site; other site 1121448003946 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK08270 1121448003947 ATP cone domain; Region: ATP-cone; pfam03477 1121448003948 Class III ribonucleotide reductase; Region: RNR_III; cd01675 1121448003949 effector binding site; other site 1121448003950 active site 1121448003951 Zn binding site [ion binding]; other site 1121448003952 glycine loop; other site 1121448003953 Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; pfam09860 1121448003954 DsrE/DsrF/DrsH-like family; Region: DrsE_2; cl17453 1121448003955 CHASE3 domain; Region: CHASE3; pfam05227 1121448003956 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1121448003957 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1121448003958 dimer interface [polypeptide binding]; other site 1121448003959 putative CheW interface [polypeptide binding]; other site 1121448003960 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1121448003961 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1121448003962 metal binding site [ion binding]; metal-binding site 1121448003963 active site 1121448003964 I-site; other site 1121448003965 Hemerythrin; Region: Hemerythrin; cd12107 1121448003966 Fe binding site [ion binding]; other site 1121448003967 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 1121448003968 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 1121448003969 Cache domain; Region: Cache_2; cl07034 1121448003970 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1121448003971 PAS domain; Region: PAS_8; pfam13188 1121448003972 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1121448003973 dimer interface [polypeptide binding]; other site 1121448003974 phosphorylation site [posttranslational modification] 1121448003975 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121448003976 ATP binding site [chemical binding]; other site 1121448003977 Mg2+ binding site [ion binding]; other site 1121448003978 G-X-G motif; other site 1121448003979 Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201 1121448003980 CheB methylesterase; Region: CheB_methylest; pfam01339 1121448003981 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 1121448003982 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 1121448003983 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 1121448003984 PAS domain; Region: PAS_10; pfam13596 1121448003985 PAS domain; Region: PAS_9; pfam13426 1121448003986 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121448003987 Response regulator receiver domain; Region: Response_reg; pfam00072 1121448003988 active site 1121448003989 phosphorylation site [posttranslational modification] 1121448003990 intermolecular recognition site; other site 1121448003991 dimerization interface [polypeptide binding]; other site 1121448003992 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121448003993 PAS domain; Region: PAS_9; pfam13426 1121448003994 putative active site [active] 1121448003995 heme pocket [chemical binding]; other site 1121448003996 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1121448003997 dimer interface [polypeptide binding]; other site 1121448003998 phosphorylation site [posttranslational modification] 1121448003999 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121448004000 ATP binding site [chemical binding]; other site 1121448004001 Mg2+ binding site [ion binding]; other site 1121448004002 G-X-G motif; other site 1121448004003 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121448004004 PAS domain; Region: PAS_9; pfam13426 1121448004005 putative active site [active] 1121448004006 heme pocket [chemical binding]; other site 1121448004007 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1121448004008 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1121448004009 dimer interface [polypeptide binding]; other site 1121448004010 phosphorylation site [posttranslational modification] 1121448004011 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121448004012 ATP binding site [chemical binding]; other site 1121448004013 Mg2+ binding site [ion binding]; other site 1121448004014 G-X-G motif; other site 1121448004015 PAS domain; Region: PAS_9; pfam13426 1121448004016 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121448004017 putative active site [active] 1121448004018 heme pocket [chemical binding]; other site 1121448004019 PAS domain S-box; Region: sensory_box; TIGR00229 1121448004020 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121448004021 putative active site [active] 1121448004022 heme pocket [chemical binding]; other site 1121448004023 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1121448004024 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 1121448004025 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121448004026 ATP binding site [chemical binding]; other site 1121448004027 G-X-G motif; other site 1121448004028 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 1121448004029 FAD binding domain; Region: FAD_binding_4; pfam01565 1121448004030 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1121448004031 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1121448004032 dimerization interface [polypeptide binding]; other site 1121448004033 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1121448004034 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 1121448004035 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1121448004036 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1121448004037 putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734 1121448004038 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1121448004039 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1121448004040 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1121448004041 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121448004042 active site 1121448004043 phosphorylation site [posttranslational modification] 1121448004044 intermolecular recognition site; other site 1121448004045 dimerization interface [polypeptide binding]; other site 1121448004046 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1121448004047 Walker A motif; other site 1121448004048 ATP binding site [chemical binding]; other site 1121448004049 Walker B motif; other site 1121448004050 arginine finger; other site 1121448004051 PAS domain; Region: PAS_9; pfam13426 1121448004052 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121448004053 ATP binding site [chemical binding]; other site 1121448004054 Mg2+ binding site [ion binding]; other site 1121448004055 G-X-G motif; other site 1121448004056 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121448004057 Response regulator receiver domain; Region: Response_reg; pfam00072 1121448004058 active site 1121448004059 phosphorylation site [posttranslational modification] 1121448004060 intermolecular recognition site; other site 1121448004061 dimerization interface [polypeptide binding]; other site 1121448004062 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1121448004063 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1121448004064 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417 1121448004065 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1121448004066 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1121448004067 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121448004068 dimer interface [polypeptide binding]; other site 1121448004069 conserved gate region; other site 1121448004070 putative PBP binding loops; other site 1121448004071 ABC-ATPase subunit interface; other site 1121448004072 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1121448004073 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121448004074 dimer interface [polypeptide binding]; other site 1121448004075 conserved gate region; other site 1121448004076 putative PBP binding loops; other site 1121448004077 ABC-ATPase subunit interface; other site 1121448004078 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 1121448004079 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 1121448004080 Walker A/P-loop; other site 1121448004081 ATP binding site [chemical binding]; other site 1121448004082 Q-loop/lid; other site 1121448004083 ABC transporter signature motif; other site 1121448004084 Walker B; other site 1121448004085 D-loop; other site 1121448004086 H-loop/switch region; other site 1121448004087 TOBE domain; Region: TOBE_2; pfam08402 1121448004088 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 1121448004089 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1121448004090 Walker A/P-loop; other site 1121448004091 ATP binding site [chemical binding]; other site 1121448004092 Q-loop/lid; other site 1121448004093 ABC transporter signature motif; other site 1121448004094 Walker B; other site 1121448004095 D-loop; other site 1121448004096 H-loop/switch region; other site 1121448004097 TOBE domain; Region: TOBE_2; pfam08402 1121448004098 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1121448004099 pseudo-rSAM protein/SPASM domain protein; Region: pseudo_SAM_Halo; TIGR04347 1121448004100 FeS/SAM binding site; other site 1121448004101 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 1121448004102 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 1121448004103 putative [4Fe-4S] binding site [ion binding]; other site 1121448004104 putative molybdopterin cofactor binding site [chemical binding]; other site 1121448004105 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 1121448004106 molybdopterin cofactor binding site; other site 1121448004107 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 1121448004108 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 1121448004109 catalytic triad [active] 1121448004110 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 1121448004111 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1121448004112 Surface antigen; Region: Bac_surface_Ag; pfam01103 1121448004113 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 1121448004114 Family of unknown function (DUF490); Region: DUF490; pfam04357 1121448004115 penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636 1121448004116 Transglycosylase; Region: Transgly; pfam00912 1121448004117 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 1121448004118 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1121448004119 nitrogenase cofactor biosynthesis protein NifB; Region: nifB; TIGR01290 1121448004120 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1121448004121 FeS/SAM binding site; other site 1121448004122 This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. This...; Region: NifX_NifB; cl00252 1121448004123 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 1121448004124 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 1121448004125 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 1121448004126 nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283 1121448004127 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 1121448004128 dimer interface [polypeptide binding]; other site 1121448004129 [2Fe-2S] cluster binding site [ion binding]; other site 1121448004130 nitrogenase cofactor biosynthesis protein NifB; Region: nifB; TIGR01290 1121448004131 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1121448004132 FeS/SAM binding site; other site 1121448004133 This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. This...; Region: NifX_NifB; cl00252 1121448004134 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 1121448004135 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 1121448004136 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 1121448004137 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 1121448004138 Nitrogen regulatory protein P-II; Region: P-II; pfam00543 1121448004139 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1121448004140 Nitrogen regulatory protein P-II; Region: P-II; pfam00543 1121448004141 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1121448004142 nitrogenase reductase; Reviewed; Region: nifH; PRK13235 1121448004143 NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040 1121448004144 Nucleotide-binding sites [chemical binding]; other site 1121448004145 Walker A motif; other site 1121448004146 Switch I region of nucleotide binding site; other site 1121448004147 Fe4S4 binding sites [ion binding]; other site 1121448004148 Switch II region of nucleotide binding site; other site 1121448004149 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 1121448004150 DNA methylase; Region: N6_N4_Mtase; pfam01555 1121448004151 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1121448004152 non-specific DNA binding site [nucleotide binding]; other site 1121448004153 salt bridge; other site 1121448004154 sequence-specific DNA binding site [nucleotide binding]; other site 1121448004155 Protein of unknown function (DUF2975); Region: DUF2975; pfam11188 1121448004156 integrase; Provisional; Region: PRK09692 1121448004157 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 1121448004158 active site 1121448004159 Int/Topo IB signature motif; other site 1121448004160 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 1121448004161 Protein of unknown function (DUF3987); Region: DUF3987; pfam13148 1121448004162 Zinc-binding domain of primase-helicase; Region: Prim_Zn_Ribbon; pfam08273 1121448004163 CHC2 zinc finger; Region: zf-CHC2; cl17510 1121448004164 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cd00188 1121448004165 active site 1121448004166 metal binding site [ion binding]; metal-binding site 1121448004167 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1121448004168 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1121448004169 P-loop; other site 1121448004170 Magnesium ion binding site [ion binding]; other site 1121448004171 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1121448004172 YcfA-like protein; Region: YcfA; pfam07927 1121448004173 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 1121448004174 Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cl00019 1121448004175 ADP-ribose binding site [chemical binding]; other site 1121448004176 Macro domain, Poa1p_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Poa1p_like; cd02901 1121448004177 ADP-ribose binding site [chemical binding]; other site 1121448004178 Protein of unknown function (DUF4065); Region: DUF4065; cl01445 1121448004179 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 1121448004180 HsdM N-terminal domain; Region: HsdM_N; pfam12161 1121448004181 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1121448004182 S-adenosylmethionine binding site [chemical binding]; other site 1121448004183 Fic/DOC family; Region: Fic; cl00960 1121448004184 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 1121448004185 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1121448004186 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1121448004187 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 1121448004188 Divergent AAA domain; Region: AAA_4; pfam04326 1121448004189 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 1121448004190 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 1121448004191 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1121448004192 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1121448004193 Protein of unknown function (DUF3010); Region: DUF3010; pfam11215 1121448004194 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 1121448004195 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 1121448004196 homodimer interaction site [polypeptide binding]; other site 1121448004197 cofactor binding site; other site 1121448004198 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1121448004199 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1121448004200 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1121448004201 Low molecular weight phosphatase family; Region: LMWPc; cl00105 1121448004202 active site 1121448004203 benzoyl-CoA reductase, subunit C; Region: benz_CoA_red_C; TIGR02263 1121448004204 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 1121448004205 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 1121448004206 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 1121448004207 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121448004208 active site 1121448004209 phosphorylation site [posttranslational modification] 1121448004210 intermolecular recognition site; other site 1121448004211 dimerization interface [polypeptide binding]; other site 1121448004212 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1121448004213 Zn2+ binding site [ion binding]; other site 1121448004214 Mg2+ binding site [ion binding]; other site 1121448004215 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1121448004216 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1121448004217 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1121448004218 dimer interface [polypeptide binding]; other site 1121448004219 phosphorylation site [posttranslational modification] 1121448004220 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121448004221 ATP binding site [chemical binding]; other site 1121448004222 Mg2+ binding site [ion binding]; other site 1121448004223 G-X-G motif; other site 1121448004224 Response regulator receiver domain; Region: Response_reg; pfam00072 1121448004225 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121448004226 active site 1121448004227 phosphorylation site [posttranslational modification] 1121448004228 intermolecular recognition site; other site 1121448004229 dimerization interface [polypeptide binding]; other site 1121448004230 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1121448004231 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121448004232 active site 1121448004233 phosphorylation site [posttranslational modification] 1121448004234 intermolecular recognition site; other site 1121448004235 dimerization interface [polypeptide binding]; other site 1121448004236 Putative regulatory protein; Region: CxxC_CXXC_SSSS; smart00834 1121448004237 Domain of unknown function (DUF4198); Region: DUF4198; pfam10670 1121448004238 cobalt transport protein CbiM; Validated; Region: PRK06265 1121448004239 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 1121448004240 This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899 1121448004241 FeoA domain; Region: FeoA; pfam04023 1121448004242 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 1121448004243 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 1121448004244 G1 box; other site 1121448004245 GTP/Mg2+ binding site [chemical binding]; other site 1121448004246 Switch I region; other site 1121448004247 G2 box; other site 1121448004248 G3 box; other site 1121448004249 Switch II region; other site 1121448004250 G4 box; other site 1121448004251 G5 box; other site 1121448004252 Nucleoside recognition; Region: Gate; pfam07670 1121448004253 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 1121448004254 Nucleoside recognition; Region: Gate; pfam07670 1121448004255 Transglycosylase; Region: Transgly; pfam00912 1121448004256 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1121448004257 RNA binding site [nucleotide binding]; other site 1121448004258 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1121448004259 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1121448004260 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1121448004261 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1121448004262 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1121448004263 S-adenosylmethionine binding site [chemical binding]; other site 1121448004264 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 1121448004265 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 1121448004266 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1121448004267 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1121448004268 active site 1121448004269 DNA polymerase IV; Validated; Region: PRK02406 1121448004270 DNA binding site [nucleotide binding] 1121448004271 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 1121448004272 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 1121448004273 active site 1121448004274 nucleotide binding site [chemical binding]; other site 1121448004275 HIGH motif; other site 1121448004276 KMSKS motif; other site 1121448004277 Flagellin N-methylase; Region: FliB; pfam03692 1121448004278 4Fe-4S binding domain; Region: Fer4; cl02805 1121448004279 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 1121448004280 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1121448004281 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1121448004282 active site residue [active] 1121448004283 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1121448004284 active site residue [active] 1121448004285 Predicted ferric reductase [Inorganic ion transport and metabolism]; Region: COG4097 1121448004286 Ferric reductase like transmembrane component; Region: Ferric_reduct; pfam01794 1121448004287 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 1121448004288 FAD binding pocket [chemical binding]; other site 1121448004289 conserved FAD binding motif [chemical binding]; other site 1121448004290 phosphate binding motif [ion binding]; other site 1121448004291 beta-alpha-beta structure motif; other site 1121448004292 NAD binding pocket [chemical binding]; other site 1121448004293 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 1121448004294 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1121448004295 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1121448004296 putative glutamate synthase subunit beta; Provisional; Region: PRK12770 1121448004297 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 1121448004298 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 1121448004299 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1121448004300 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1121448004301 homodimer interface [polypeptide binding]; other site 1121448004302 catalytic residue [active] 1121448004303 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1121448004304 FAD binding domain; Region: FAD_binding_4; pfam01565 1121448004305 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 1121448004306 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1121448004307 Cysteine-rich domain; Region: CCG; pfam02754 1121448004308 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 1121448004309 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1121448004310 catalytic residue [active] 1121448004311 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 1121448004312 YceG-like family; Region: YceG; pfam02618 1121448004313 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 1121448004314 dimerization interface [polypeptide binding]; other site 1121448004315 phosphoglycerate kinase; Provisional; Region: pgk; PRK00073 1121448004316 Phosphoglycerate kinase; Region: PGK; pfam00162 1121448004317 substrate binding site [chemical binding]; other site 1121448004318 hinge regions; other site 1121448004319 ADP binding site [chemical binding]; other site 1121448004320 catalytic site [active] 1121448004321 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 1121448004322 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1121448004323 TPP-binding site [chemical binding]; other site 1121448004324 dimer interface [polypeptide binding]; other site 1121448004325 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1121448004326 PYR/PP interface [polypeptide binding]; other site 1121448004327 dimer interface [polypeptide binding]; other site 1121448004328 TPP binding site [chemical binding]; other site 1121448004329 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1121448004330 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 1121448004331 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1121448004332 metal binding site [ion binding]; metal-binding site 1121448004333 substrate binding site [chemical binding]; other site 1121448004334 hexamer interface [polypeptide binding]; other site 1121448004335 Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765 1121448004336 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1121448004337 DNA binding residues [nucleotide binding] 1121448004338 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1121448004339 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1121448004340 putative tRNA-binding site [nucleotide binding]; other site 1121448004341 B3/4 domain; Region: B3_4; pfam03483 1121448004342 tRNA synthetase B5 domain; Region: B5; smart00874 1121448004343 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1121448004344 dimer interface [polypeptide binding]; other site 1121448004345 motif 1; other site 1121448004346 motif 3; other site 1121448004347 motif 2; other site 1121448004348 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 1121448004349 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1121448004350 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1121448004351 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1121448004352 dimer interface [polypeptide binding]; other site 1121448004353 motif 1; other site 1121448004354 active site 1121448004355 motif 2; other site 1121448004356 motif 3; other site 1121448004357 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1121448004358 23S rRNA binding site [nucleotide binding]; other site 1121448004359 L21 binding site [polypeptide binding]; other site 1121448004360 L13 binding site [polypeptide binding]; other site 1121448004361 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 1121448004362 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 1121448004363 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1121448004364 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1121448004365 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 1121448004366 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1121448004367 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1121448004368 active site 1121448004369 dimer interface [polypeptide binding]; other site 1121448004370 motif 1; other site 1121448004371 motif 2; other site 1121448004372 motif 3; other site 1121448004373 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1121448004374 anticodon binding site; other site 1121448004375 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 1121448004376 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 1121448004377 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 1121448004378 formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553 1121448004379 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 1121448004380 [4Fe-4S] binding site [ion binding]; other site 1121448004381 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1121448004382 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 1121448004383 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 1121448004384 molybdopterin cofactor binding site; other site 1121448004385 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 1121448004386 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 1121448004387 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1121448004388 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1121448004389 catalytic residues [active] 1121448004390 Methylamine utilisation protein MauE; Region: MauE; pfam07291 1121448004391 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1121448004392 active site 1121448004393 catalytic residues [active] 1121448004394 DNA binding site [nucleotide binding] 1121448004395 Int/Topo IB signature motif; other site 1121448004396 molybdenum-pterin binding domain; Region: Mop; TIGR00638 1121448004397 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 1121448004398 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1121448004399 Domain of unknown function (DUF1737); Region: DUF1737; cl10503 1121448004400 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 1121448004401 active site 1121448004402 oligomerization interface [polypeptide binding]; other site 1121448004403 metal binding site [ion binding]; metal-binding site 1121448004404 TPR repeat; Region: TPR_11; pfam13414 1121448004405 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1121448004406 binding surface 1121448004407 TPR motif; other site 1121448004408 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1121448004409 binding surface 1121448004410 TPR motif; other site 1121448004411 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 1121448004412 dimer interface [polypeptide binding]; other site 1121448004413 Citrate synthase; Region: Citrate_synt; pfam00285 1121448004414 active site 1121448004415 citrylCoA binding site [chemical binding]; other site 1121448004416 NADH binding [chemical binding]; other site 1121448004417 cationic pore residues; other site 1121448004418 oxalacetate/citrate binding site [chemical binding]; other site 1121448004419 coenzyme A binding site [chemical binding]; other site 1121448004420 catalytic triad [active] 1121448004421 Cache domain; Region: Cache_1; pfam02743 1121448004422 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1121448004423 dimerization interface [polypeptide binding]; other site 1121448004424 PAS domain; Region: PAS_9; pfam13426 1121448004425 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121448004426 putative active site [active] 1121448004427 heme pocket [chemical binding]; other site 1121448004428 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1121448004429 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1121448004430 dimer interface [polypeptide binding]; other site 1121448004431 putative CheW interface [polypeptide binding]; other site 1121448004432 Glucokinase; Region: Glucokinase; cl17310 1121448004433 Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023 1121448004434 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1121448004435 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1121448004436 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1121448004437 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1121448004438 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1121448004439 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 1121448004440 putative active site [active] 1121448004441 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 1121448004442 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1121448004443 active site 1121448004444 dimer interface [polypeptide binding]; other site 1121448004445 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 1121448004446 active site 1121448004447 catalytic residues [active] 1121448004448 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1121448004449 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1121448004450 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1121448004451 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1121448004452 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1121448004453 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1121448004454 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1121448004455 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1121448004456 dimerization interface [polypeptide binding]; other site 1121448004457 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1121448004458 dimer interface [polypeptide binding]; other site 1121448004459 phosphorylation site [posttranslational modification] 1121448004460 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121448004461 ATP binding site [chemical binding]; other site 1121448004462 Mg2+ binding site [ion binding]; other site 1121448004463 G-X-G motif; other site 1121448004464 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 1121448004465 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1121448004466 inhibitor-cofactor binding pocket; inhibition site 1121448004467 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1121448004468 catalytic residue [active] 1121448004469 cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788 1121448004470 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 1121448004471 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 1121448004472 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 1121448004473 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 1121448004474 active site 1121448004475 SAM binding site [chemical binding]; other site 1121448004476 homodimer interface [polypeptide binding]; other site 1121448004477 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1121448004478 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 1121448004479 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1121448004480 S-adenosylmethionine binding site [chemical binding]; other site 1121448004481 Uncharacterized protein conserved in bacteria (DUF2065); Region: DUF2065; cl01275 1121448004482 Vi polysaccharide biosynthesis protein TviB; Provisional; Region: PRK15182 1121448004483 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1121448004484 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1121448004485 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1121448004486 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1121448004487 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1121448004488 substrate binding pocket [chemical binding]; other site 1121448004489 chain length determination region; other site 1121448004490 substrate-Mg2+ binding site; other site 1121448004491 catalytic residues [active] 1121448004492 aspartate-rich region 1; other site 1121448004493 active site lid residues [active] 1121448004494 aspartate-rich region 2; other site 1121448004495 Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain [Nucleotide transport and metabolism]; Region: PurL; COG0046 1121448004496 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1121448004497 dimerization interface [polypeptide binding]; other site 1121448004498 ATP binding site [chemical binding]; other site 1121448004499 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 1121448004500 dimerization interface [polypeptide binding]; other site 1121448004501 ATP binding site [chemical binding]; other site 1121448004502 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 1121448004503 sensory histidine kinase AtoS; Provisional; Region: PRK11360 1121448004504 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 1121448004505 dimer interface [polypeptide binding]; other site 1121448004506 phosphorylation site [posttranslational modification] 1121448004507 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121448004508 ATP binding site [chemical binding]; other site 1121448004509 Mg2+ binding site [ion binding]; other site 1121448004510 G-X-G motif; other site 1121448004511 Response regulator receiver domain; Region: Response_reg; pfam00072 1121448004512 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121448004513 active site 1121448004514 phosphorylation site [posttranslational modification] 1121448004515 intermolecular recognition site; other site 1121448004516 dimerization interface [polypeptide binding]; other site 1121448004517 HDOD domain; Region: HDOD; pfam08668 1121448004518 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1121448004519 Zn2+ binding site [ion binding]; other site 1121448004520 Mg2+ binding site [ion binding]; other site 1121448004521 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 1121448004522 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121448004523 active site 1121448004524 phosphorylation site [posttranslational modification] 1121448004525 intermolecular recognition site; other site 1121448004526 dimerization interface [polypeptide binding]; other site 1121448004527 HD domain; Region: HD_5; pfam13487 1121448004528 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1121448004529 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1121448004530 Ligand binding site; other site 1121448004531 Putative Catalytic site; other site 1121448004532 DXD motif; other site 1121448004533 YdjC-like protein; Region: YdjC; pfam04794 1121448004534 Uncharacterized ArCR, COG2043; Region: DUF169; cl00894 1121448004535 Low-temperature-induced protein; Provisional; Region: PLN03021 1121448004536 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1121448004537 transmembrane helices; other site 1121448004538 TrkA-C domain; Region: TrkA_C; pfam02080 1121448004539 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1121448004540 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1121448004541 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1121448004542 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1121448004543 phosphate binding site [ion binding]; other site 1121448004544 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 1121448004545 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 1121448004546 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1121448004547 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1121448004548 Cysteine-rich domain; Region: CCG; pfam02754 1121448004549 Cysteine-rich domain; Region: CCG; pfam02754 1121448004550 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 1121448004551 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 1121448004552 propionate/acetate kinase; Provisional; Region: PRK12379 1121448004553 phosphate acetyltransferase; Reviewed; Region: PRK05632 1121448004554 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1121448004555 DRTGG domain; Region: DRTGG; pfam07085 1121448004556 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 1121448004557 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1121448004558 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1121448004559 Cysteine-rich domain; Region: CCG; pfam02754 1121448004560 Cysteine-rich domain; Region: CCG; pfam02754 1121448004561 FAD binding domain; Region: FAD_binding_4; pfam01565 1121448004562 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 1121448004563 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 1121448004564 L-lactate permease; Region: Lactate_perm; cl00701 1121448004565 Response regulator receiver domain; Region: Response_reg; pfam00072 1121448004566 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121448004567 active site 1121448004568 phosphorylation site [posttranslational modification] 1121448004569 intermolecular recognition site; other site 1121448004570 dimerization interface [polypeptide binding]; other site 1121448004571 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1121448004572 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1121448004573 Walker A motif; other site 1121448004574 ATP binding site [chemical binding]; other site 1121448004575 Walker B motif; other site 1121448004576 arginine finger; other site 1121448004577 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 1121448004578 ApbE family; Region: ApbE; pfam02424 1121448004579 ferredoxin; Validated; Region: PRK07118 1121448004580 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1121448004581 Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597 1121448004582 electron transport complex RsxE subunit; Provisional; Region: PRK12405 1121448004583 FMN-binding domain; Region: FMN_bind; cl01081 1121448004584 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; pfam03116 1121448004585 electron transport complex, RnfABCDGE type, C subunit; Region: rnfC; TIGR01945 1121448004586 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1121448004587 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 1121448004588 heme-binding residues [chemical binding]; other site 1121448004589 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 1121448004590 heme-binding residues [chemical binding]; other site 1121448004591 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 1121448004592 heme-binding residues [chemical binding]; other site 1121448004593 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 1121448004594 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1121448004595 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 1121448004596 acyl-activating enzyme (AAE) consensus motif; other site 1121448004597 AMP binding site [chemical binding]; other site 1121448004598 active site 1121448004599 CoA binding site [chemical binding]; other site 1121448004600 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1121448004601 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 1121448004602 non-specific DNA binding site [nucleotide binding]; other site 1121448004603 salt bridge; other site 1121448004604 sequence-specific DNA binding site [nucleotide binding]; other site 1121448004605 Cupin domain; Region: Cupin_2; pfam07883 1121448004606 PAS domain; Region: PAS_8; pfam13188 1121448004607 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1121448004608 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1121448004609 dimer interface [polypeptide binding]; other site 1121448004610 phosphorylation site [posttranslational modification] 1121448004611 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121448004612 ATP binding site [chemical binding]; other site 1121448004613 Mg2+ binding site [ion binding]; other site 1121448004614 G-X-G motif; other site 1121448004615 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1121448004616 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1121448004617 substrate binding pocket [chemical binding]; other site 1121448004618 membrane-bound complex binding site; other site 1121448004619 hinge residues; other site 1121448004620 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1121448004621 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1121448004622 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1121448004623 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1121448004624 dimer interface [polypeptide binding]; other site 1121448004625 phosphorylation site [posttranslational modification] 1121448004626 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121448004627 ATP binding site [chemical binding]; other site 1121448004628 Mg2+ binding site [ion binding]; other site 1121448004629 G-X-G motif; other site 1121448004630 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1121448004631 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121448004632 active site 1121448004633 phosphorylation site [posttranslational modification] 1121448004634 intermolecular recognition site; other site 1121448004635 dimerization interface [polypeptide binding]; other site 1121448004636 thiamine monophosphate kinase; Provisional; Region: PRK05731 1121448004637 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 1121448004638 ATP binding site [chemical binding]; other site 1121448004639 dimerization interface [polypeptide binding]; other site 1121448004640 biotin synthase; Provisional; Region: PRK08508 1121448004641 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 1121448004642 BioY family; Region: BioY; pfam02632 1121448004643 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 1121448004644 homodimer interaction site [polypeptide binding]; other site 1121448004645 cofactor binding site; other site 1121448004646 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; cl08354 1121448004647 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 1121448004648 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 1121448004649 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 1121448004650 Uncharacterized Fe-S center protein [General function prediction only]; Region: COG2768 1121448004651 Uncharacterized conserved protein [Function unknown]; Region: COG2006 1121448004652 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1121448004653 Domain of unknown function (DUF3391); Region: DUF3391; pfam11871 1121448004654 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1121448004655 Zn2+ binding site [ion binding]; other site 1121448004656 Mg2+ binding site [ion binding]; other site 1121448004657 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1121448004658 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1121448004659 Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633 1121448004660 Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295 1121448004661 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 1121448004662 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1121448004663 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1121448004664 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 1121448004665 active site residue [active] 1121448004666 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 1121448004667 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1121448004668 Walker A/P-loop; other site 1121448004669 ATP binding site [chemical binding]; other site 1121448004670 Q-loop/lid; other site 1121448004671 ABC transporter signature motif; other site 1121448004672 Walker B; other site 1121448004673 D-loop; other site 1121448004674 H-loop/switch region; other site 1121448004675 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1121448004676 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1121448004677 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1121448004678 Walker A/P-loop; other site 1121448004679 ATP binding site [chemical binding]; other site 1121448004680 Q-loop/lid; other site 1121448004681 ABC transporter signature motif; other site 1121448004682 Walker B; other site 1121448004683 D-loop; other site 1121448004684 H-loop/switch region; other site 1121448004685 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1121448004686 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1121448004687 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121448004688 dimer interface [polypeptide binding]; other site 1121448004689 conserved gate region; other site 1121448004690 putative PBP binding loops; other site 1121448004691 ABC-ATPase subunit interface; other site 1121448004692 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1121448004693 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121448004694 dimer interface [polypeptide binding]; other site 1121448004695 conserved gate region; other site 1121448004696 putative PBP binding loops; other site 1121448004697 ABC-ATPase subunit interface; other site 1121448004698 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498 1121448004699 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1121448004700 Predicted permease; Region: DUF318; cl17795 1121448004701 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1121448004702 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_4; cd03795 1121448004703 putative ADP-binding pocket [chemical binding]; other site 1121448004704 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 1121448004705 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1121448004706 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 1121448004707 heme-binding residues [chemical binding]; other site 1121448004708 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 1121448004709 4Fe-4S binding domain; Region: Fer4; pfam00037 1121448004710 Nitroreductase family; Region: Nitroreductase; pfam00881 1121448004711 FMN binding site [chemical binding]; other site 1121448004712 dimer interface [polypeptide binding]; other site 1121448004713 Protein of unknown function (DUF1499); Region: DUF1499; pfam07386 1121448004714 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1121448004715 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1121448004716 GIY-YIG motif/motif A; other site 1121448004717 active site 1121448004718 catalytic site [active] 1121448004719 putative DNA binding site [nucleotide binding]; other site 1121448004720 metal binding site [ion binding]; metal-binding site 1121448004721 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1121448004722 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 1121448004723 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 1121448004724 histidinol dehydrogenase; Region: hisD; TIGR00069 1121448004725 NAD binding site [chemical binding]; other site 1121448004726 dimerization interface [polypeptide binding]; other site 1121448004727 product binding site; other site 1121448004728 substrate binding site [chemical binding]; other site 1121448004729 zinc binding site [ion binding]; other site 1121448004730 catalytic residues [active] 1121448004731 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 1121448004732 ATP binding site [chemical binding]; other site 1121448004733 active site 1121448004734 substrate binding site [chemical binding]; other site 1121448004735 Protein of unknown function, DUF488; Region: DUF488; pfam04343 1121448004736 Protein of unknown function, DUF488; Region: DUF488; pfam04343 1121448004737 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 1121448004738 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1121448004739 FeS/SAM binding site; other site 1121448004740 Cupin domain; Region: Cupin_2; cl17218 1121448004741 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1121448004742 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1121448004743 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1121448004744 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1121448004745 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1121448004746 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1121448004747 active site 1121448004748 Acyl-CoA dehydrogenase, C-terminal domain; Region: Acyl-CoA_dh_1; pfam00441 1121448004749 active site 1121448004750 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 1121448004751 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 1121448004752 Ligand Binding Site [chemical binding]; other site 1121448004753 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 1121448004754 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 1121448004755 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1121448004756 Walker A motif; other site 1121448004757 ATP binding site [chemical binding]; other site 1121448004758 Walker B motif; other site 1121448004759 arginine finger; other site 1121448004760 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1121448004761 phage shock protein A; Region: phageshock_pspA; TIGR02977 1121448004762 Phage shock protein B; Region: PspB; cl05946 1121448004763 PspC domain; Region: PspC; pfam04024 1121448004764 phage shock protein C; Region: phageshock_pspC; TIGR02978 1121448004765 Maf-like protein; Region: Maf; pfam02545 1121448004766 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1121448004767 active site 1121448004768 dimer interface [polypeptide binding]; other site 1121448004769 Anti-sigma-28 factor, FlgM; Region: FlgM; pfam04316 1121448004770 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 1121448004771 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1121448004772 dimerization interface [polypeptide binding]; other site 1121448004773 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1121448004774 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1121448004775 dimer interface [polypeptide binding]; other site 1121448004776 putative CheW interface [polypeptide binding]; other site 1121448004777 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1121448004778 active site residue [active] 1121448004779 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 1121448004780 dinuclear metal binding motif [ion binding]; other site 1121448004781 Uncharacterized conserved protein [Function unknown]; Region: COG2006 1121448004782 Domain of unknown function (DUF362); Region: DUF362; pfam04015 1121448004783 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 1121448004784 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1121448004785 minor groove reading motif; other site 1121448004786 helix-hairpin-helix signature motif; other site 1121448004787 substrate binding pocket [chemical binding]; other site 1121448004788 active site 1121448004789 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 1121448004790 active site 1121448004791 8-oxo-dGMP binding site [chemical binding]; other site 1121448004792 nudix motif; other site 1121448004793 metal binding site [ion binding]; metal-binding site 1121448004794 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1121448004795 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1121448004796 ligand binding site [chemical binding]; other site 1121448004797 flexible hinge region; other site 1121448004798 helix_turn_helix, cAMP Regulatory protein; Region: HTH_CRP; smart00419 1121448004799 hybrid cluster protein; Provisional; Region: PRK05290 1121448004800 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1121448004801 ACS interaction site; other site 1121448004802 CODH interaction site; other site 1121448004803 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 1121448004804 hybrid metal cluster; other site 1121448004805 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527 1121448004806 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 1121448004807 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 1121448004808 ATP synthase subunit C; Region: ATP-synt_C; cl00466 1121448004809 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 1121448004810 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 1121448004811 CoA binding domain; Region: CoA_binding; pfam02629 1121448004812 S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887 1121448004813 cobalamin synthase; Reviewed; Region: cobS; PRK00235 1121448004814 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 1121448004815 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1121448004816 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1121448004817 Dihydroorotase and related cyclic amidohydrolases [Nucleotide transport and metabolism]; Region: PyrC; COG0044 1121448004818 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 1121448004819 active site 1121448004820 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 1121448004821 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 1121448004822 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14460 1121448004823 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1121448004824 FeS/SAM binding site; other site 1121448004825 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 1121448004826 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 1121448004827 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 1121448004828 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 1121448004829 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 1121448004830 cytochrome c nitrate reductase, small subunit; Region: cytochr_NrfH; TIGR03153 1121448004831 Cytochrome c552; Region: Cytochrom_C552; pfam02335 1121448004832 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1121448004833 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1121448004834 Coenzyme A binding pocket [chemical binding]; other site 1121448004835 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 1121448004836 Response regulator receiver domain; Region: Response_reg; pfam00072 1121448004837 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121448004838 active site 1121448004839 phosphorylation site [posttranslational modification] 1121448004840 intermolecular recognition site; other site 1121448004841 dimerization interface [polypeptide binding]; other site 1121448004842 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 1121448004843 UbiA prenyltransferase family; Region: UbiA; pfam01040 1121448004844 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1121448004845 MPT binding site; other site 1121448004846 trimer interface [polypeptide binding]; other site 1121448004847 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 1121448004848 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 1121448004849 substrate binding site; other site 1121448004850 tetramer interface; other site 1121448004851 TRAM domain; Region: TRAM; cl01282 1121448004852 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 1121448004853 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1121448004854 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 1121448004855 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 1121448004856 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 1121448004857 putative active site [active] 1121448004858 oxyanion strand; other site 1121448004859 catalytic triad [active] 1121448004860 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 1121448004861 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1121448004862 substrate binding site [chemical binding]; other site 1121448004863 glutamase interaction surface [polypeptide binding]; other site 1121448004864 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 1121448004865 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 1121448004866 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 1121448004867 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 1121448004868 Predicted phosphoesterases, related to the Icc protein [General function prediction only]; Region: COG2129 1121448004869 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1121448004870 active site 1121448004871 metal binding site [ion binding]; metal-binding site 1121448004872 SdiA-regulated; Region: SdiA-regulated; cd09971 1121448004873 putative active site [active] 1121448004874 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1121448004875 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121448004876 active site 1121448004877 phosphorylation site [posttranslational modification] 1121448004878 intermolecular recognition site; other site 1121448004879 dimerization interface [polypeptide binding]; other site 1121448004880 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1121448004881 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1121448004882 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1121448004883 Phosphotransferase enzyme family; Region: APH; pfam01636 1121448004884 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1121448004885 active site 1121448004886 substrate binding site [chemical binding]; other site 1121448004887 ATP binding site [chemical binding]; other site 1121448004888 Putative heavy-metal-binding; Region: YbjQ_1; pfam01906 1121448004889 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 1121448004890 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 1121448004891 CoA enzyme activase uncharacterized domain (DUF2229); Region: DUF2229; cl17855 1121448004892 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 1121448004893 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 1121448004894 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1121448004895 active site 1121448004896 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1121448004897 Protein phosphatase 2C; Region: PP2C; pfam00481 1121448004898 active site 1121448004899 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1121448004900 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1121448004901 substrate binding pocket [chemical binding]; other site 1121448004902 membrane-bound complex binding site; other site 1121448004903 hinge residues; other site 1121448004904 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121448004905 PAS fold; Region: PAS_3; pfam08447 1121448004906 putative active site [active] 1121448004907 heme pocket [chemical binding]; other site 1121448004908 PAS domain; Region: PAS_9; pfam13426 1121448004909 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1121448004910 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1121448004911 phosphorylation site [posttranslational modification] 1121448004912 dimer interface [polypeptide binding]; other site 1121448004913 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121448004914 ATP binding site [chemical binding]; other site 1121448004915 Mg2+ binding site [ion binding]; other site 1121448004916 G-X-G motif; other site 1121448004917 ABC1 family; Region: ABC1; cl17513 1121448004918 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 1121448004919 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1121448004920 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1121448004921 putative active site [active] 1121448004922 putative metal binding site [ion binding]; other site 1121448004923 enoyl-CoA hydratase; Provisional; Region: PRK08252 1121448004924 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1121448004925 substrate binding site [chemical binding]; other site 1121448004926 oxyanion hole (OAH) forming residues; other site 1121448004927 trimer interface [polypeptide binding]; other site 1121448004928 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1121448004929 ornithine cyclodeaminase; Validated; Region: PRK07340 1121448004930 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 1121448004931 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 1121448004932 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 1121448004933 NADP binding site [chemical binding]; other site 1121448004934 active site 1121448004935 putative substrate binding site [chemical binding]; other site 1121448004936 Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), N-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_N; cd03412 1121448004937 Cobalt chelatase (CbiK); Region: CbiK; pfam06180 1121448004938 active site 1121448004939 C-terminal domain interface [polypeptide binding]; other site 1121448004940 Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), C-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_C; cd03413 1121448004941 active site 1121448004942 N-terminal domain interface [polypeptide binding]; other site 1121448004943 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1121448004944 active site residue [active] 1121448004945 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1121448004946 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1121448004947 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1121448004948 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1121448004949 Cysteine-rich domain; Region: CCG; pfam02754 1121448004950 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 1121448004951 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 1121448004952 RNase E interface [polypeptide binding]; other site 1121448004953 trimer interface [polypeptide binding]; other site 1121448004954 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 1121448004955 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 1121448004956 RNase E interface [polypeptide binding]; other site 1121448004957 trimer interface [polypeptide binding]; other site 1121448004958 active site 1121448004959 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 1121448004960 putative nucleic acid binding region [nucleotide binding]; other site 1121448004961 G-X-X-G motif; other site 1121448004962 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1121448004963 RNA binding site [nucleotide binding]; other site 1121448004964 domain interface; other site 1121448004965 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1121448004966 16S/18S rRNA binding site [nucleotide binding]; other site 1121448004967 S13e-L30e interaction site [polypeptide binding]; other site 1121448004968 25S rRNA binding site [nucleotide binding]; other site 1121448004969 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1121448004970 tRNA pseudouridine(55) synthase; Region: TruB; TIGR00431 1121448004971 RNA binding site [nucleotide binding]; other site 1121448004972 active site 1121448004973 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 1121448004974 DHH family; Region: DHH; pfam01368 1121448004975 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 1121448004976 Protein of unknown function (DUF503); Region: DUF503; pfam04456 1121448004977 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1121448004978 translation initiation factor IF-2; Region: IF-2; TIGR00487 1121448004979 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1121448004980 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1121448004981 G1 box; other site 1121448004982 putative GEF interaction site [polypeptide binding]; other site 1121448004983 GTP/Mg2+ binding site [chemical binding]; other site 1121448004984 Switch I region; other site 1121448004985 G2 box; other site 1121448004986 G3 box; other site 1121448004987 Switch II region; other site 1121448004988 G4 box; other site 1121448004989 G5 box; other site 1121448004990 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1121448004991 Translation-initiation factor 2; Region: IF-2; pfam11987 1121448004992 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1121448004993 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cl00189 1121448004994 putative RNA binding cleft [nucleotide binding]; other site 1121448004995 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 1121448004996 NusA N-terminal domain; Region: NusA_N; pfam08529 1121448004997 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1121448004998 RNA binding site [nucleotide binding]; other site 1121448004999 homodimer interface [polypeptide binding]; other site 1121448005000 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1121448005001 G-X-X-G motif; other site 1121448005002 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1121448005003 G-X-X-G motif; other site 1121448005004 Sm and related proteins; Region: Sm_like; cl00259 1121448005005 ribosome maturation protein RimP; Reviewed; Region: PRK00092 1121448005006 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 1121448005007 putative oligomer interface [polypeptide binding]; other site 1121448005008 putative RNA binding site [nucleotide binding]; other site 1121448005009 Quinol:fumarate reductase (QFR) Type B subfamily, transmembrane subunit; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinone...; Region: QFR_TypeB_TM; cd00581 1121448005010 Iron-sulfur protein interface; other site 1121448005011 proximal heme binding site [chemical binding]; other site 1121448005012 distal heme binding site [chemical binding]; other site 1121448005013 dimer interface [polypeptide binding]; other site 1121448005014 fumarate reductase flavoprotein subunit; Provisional; Region: PRK08626 1121448005015 L-aspartate oxidase; Provisional; Region: PRK06175 1121448005016 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1121448005017 fumarate reductase iron-sulfur subunit; Provisional; Region: frdB; PRK13552 1121448005018 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1121448005019 fumarate hydratase; Provisional; Region: PRK06246 1121448005020 Fumarase C-terminus; Region: Fumerase_C; cl00795 1121448005021 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 1121448005022 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1121448005023 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 1121448005024 putative NAD(P) binding site [chemical binding]; other site 1121448005025 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1121448005026 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 1121448005027 transmembrane helices; other site 1121448005028 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1121448005029 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 1121448005030 transmembrane helices; other site 1121448005031 putative oxidoreductase; Provisional; Region: PRK12831 1121448005032 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1121448005033 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1121448005034 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 1121448005035 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 1121448005036 dimer interface [polypeptide binding]; other site 1121448005037 phosphorylation site [posttranslational modification] 1121448005038 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121448005039 ATP binding site [chemical binding]; other site 1121448005040 Mg2+ binding site [ion binding]; other site 1121448005041 G-X-G motif; other site 1121448005042 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121448005043 active site 1121448005044 phosphorylation site [posttranslational modification] 1121448005045 intermolecular recognition site; other site 1121448005046 dimerization interface [polypeptide binding]; other site 1121448005047 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1121448005048 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121448005049 active site 1121448005050 phosphorylation site [posttranslational modification] 1121448005051 intermolecular recognition site; other site 1121448005052 dimerization interface [polypeptide binding]; other site 1121448005053 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1121448005054 Walker A motif; other site 1121448005055 ATP binding site [chemical binding]; other site 1121448005056 Walker B motif; other site 1121448005057 arginine finger; other site 1121448005058 shikimate 5-dehydrogenase; Reviewed; Region: PRK12550 1121448005059 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1121448005060 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1121448005061 shikimate binding site; other site 1121448005062 NAD(P) binding site [chemical binding]; other site 1121448005063 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 1121448005064 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 1121448005065 Substrate binding site; other site 1121448005066 Cupin domain; Region: Cupin_2; cl17218 1121448005067 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 1121448005068 Uncharacterized protein conserved in archaea [Function unknown]; Region: COG3366 1121448005069 ATP-dependent protease Clp, ATPase subunit [Posttranslational modification, protein turnover, chaperones]; Region: ClpX; COG1219 1121448005070 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 1121448005071 Bacteriophage CI repressor helix-turn-helix domain; Region: Phage_CI_repr; pfam07022 1121448005072 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462 1121448005073 Catalytic site [active] 1121448005074 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 1121448005075 sequence-specific DNA binding site [nucleotide binding]; other site 1121448005076 salt bridge; other site 1121448005077 HflC protein; Region: hflC; TIGR01932 1121448005078 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 1121448005079 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 1121448005080 HflK protein; Region: hflK; TIGR01933 1121448005081 PhnA protein; Region: PhnA; pfam03831 1121448005082 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 1121448005083 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1121448005084 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1121448005085 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1121448005086 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1121448005087 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1121448005088 putative acyl-acceptor binding pocket; other site 1121448005089 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 1121448005090 elongation factor G; Reviewed; Region: PRK12740 1121448005091 G1 box; other site 1121448005092 putative GEF interaction site [polypeptide binding]; other site 1121448005093 GTP/Mg2+ binding site [chemical binding]; other site 1121448005094 Switch I region; other site 1121448005095 G2 box; other site 1121448005096 G3 box; other site 1121448005097 Switch II region; other site 1121448005098 G4 box; other site 1121448005099 G5 box; other site 1121448005100 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1121448005101 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1121448005102 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1121448005103 aminodeoxychorismate synthase; Provisional; Region: PRK07508 1121448005104 chorismate binding enzyme; Region: Chorismate_bind; cl10555 1121448005105 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 1121448005106 substrate-cofactor binding pocket; other site 1121448005107 homodimer interface [polypeptide binding]; other site 1121448005108 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1121448005109 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1121448005110 catalytic residue [active] 1121448005111 TraB family; Region: TraB; pfam01963 1121448005112 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1121448005113 dimer interface [polypeptide binding]; other site 1121448005114 putative CheW interface [polypeptide binding]; other site 1121448005115 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1121448005116 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1121448005117 substrate binding pocket [chemical binding]; other site 1121448005118 membrane-bound complex binding site; other site 1121448005119 hinge residues; other site 1121448005120 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1121448005121 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1121448005122 ligand binding site [chemical binding]; other site 1121448005123 flexible hinge region; other site 1121448005124 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1121448005125 metal binding site 2 [ion binding]; metal-binding site 1121448005126 putative DNA binding helix; other site 1121448005127 metal binding site 1 [ion binding]; metal-binding site 1121448005128 dimer interface [polypeptide binding]; other site 1121448005129 structural Zn2+ binding site [ion binding]; other site 1121448005130 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 1121448005131 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1121448005132 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121448005133 active site 1121448005134 phosphorylation site [posttranslational modification] 1121448005135 intermolecular recognition site; other site 1121448005136 dimerization interface [polypeptide binding]; other site 1121448005137 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 1121448005138 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1121448005139 minor groove reading motif; other site 1121448005140 helix-hairpin-helix signature motif; other site 1121448005141 substrate binding pocket [chemical binding]; other site 1121448005142 active site 1121448005143 Uncharacterized protein involved in tolerance to divalent cations [Inorganic ion transport and metabolism]; Region: CutA; COG1324 1121448005144 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1121448005145 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 1121448005146 substrate binding site [chemical binding]; other site 1121448005147 ATP binding site [chemical binding]; other site 1121448005148 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 1121448005149 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 1121448005150 active site 1121448005151 Zn binding site [ion binding]; other site 1121448005152 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 1121448005153 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1121448005154 active site 1121448005155 dimer interface [polypeptide binding]; other site 1121448005156 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1121448005157 Ligand Binding Site [chemical binding]; other site 1121448005158 Molecular Tunnel; other site 1121448005159 flavodoxin, short chain; Region: flav_short; TIGR01753 1121448005160 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1121448005161 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1121448005162 P-loop; other site 1121448005163 Magnesium ion binding site [ion binding]; other site 1121448005164 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1121448005165 Magnesium ion binding site [ion binding]; other site 1121448005166 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1121448005167 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1121448005168 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the GGDEF (DiGuanylate-Cyclase (DGC)) domain. The GGDEF domain has been suggested to be homologous to the adenylyl cyclase catalytic domain and...; Region: CBS_pair_GGDEF_assoc; cd04598 1121448005169 FOG: CBS domain [General function prediction only]; Region: COG0517 1121448005170 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1121448005171 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1121448005172 metal binding site [ion binding]; metal-binding site 1121448005173 active site 1121448005174 I-site; other site 1121448005175 Response regulator receiver domain; Region: Response_reg; pfam00072 1121448005176 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121448005177 active site 1121448005178 phosphorylation site [posttranslational modification] 1121448005179 intermolecular recognition site; other site 1121448005180 dimerization interface [polypeptide binding]; other site 1121448005181 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 1121448005182 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1121448005183 Flavodoxin; Region: Flavodoxin_1; pfam00258 1121448005184 Rubredoxin [Energy production and conversion]; Region: COG1773 1121448005185 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 1121448005186 iron binding site [ion binding]; other site 1121448005187 AzlC protein; Region: AzlC; cl00570 1121448005188 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 1121448005189 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 1121448005190 classical (c) SDRs; Region: SDR_c; cd05233 1121448005191 NAD(P) binding site [chemical binding]; other site 1121448005192 active site 1121448005193 Predicted Zn-dependent peptidases, insulinase-like [General function prediction only]; Region: COG1026 1121448005194 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1121448005195 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1121448005196 Peptidase M16C associated; Region: M16C_assoc; pfam08367 1121448005197 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 1121448005198 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1121448005199 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 1121448005200 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1121448005201 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 1121448005202 Uncharacterized conserved protein [Function unknown]; Region: COG3391 1121448005203 NHL repeat; Region: NHL; pfam01436 1121448005204 NHL repeat; Region: NHL; pfam01436 1121448005205 NHL repeat; Region: NHL; pfam01436 1121448005206 NHL repeat; Region: NHL; pfam01436 1121448005207 Uncharacterized conserved protein [Function unknown]; Region: COG3391 1121448005208 NHL repeat; Region: NHL; pfam01436 1121448005209 NHL repeat; Region: NHL; pfam01436 1121448005210 NHL repeat; Region: NHL; pfam01436 1121448005211 NHL repeat; Region: NHL; pfam01436 1121448005212 NHL repeat; Region: NHL; pfam01436 1121448005213 NHL repeat; Region: NHL; pfam01436 1121448005214 NHL repeat; Region: NHL; pfam01436 1121448005215 NHL repeat; Region: NHL; pfam01436 1121448005216 NHL repeat; Region: NHL; pfam01436 1121448005217 NHL repeat; Region: NHL; pfam01436 1121448005218 NHL repeat; Region: NHL; pfam01436 1121448005219 Uncharacterized conserved protein [Function unknown]; Region: COG3391 1121448005220 NHL repeat; Region: NHL; pfam01436 1121448005221 NHL repeat; Region: NHL; pfam01436 1121448005222 NHL repeat; Region: NHL; pfam01436 1121448005223 NHL repeat; Region: NHL; pfam01436 1121448005224 NHL repeat; Region: NHL; pfam01436 1121448005225 NHL repeat; Region: NHL; pfam01436 1121448005226 NHL repeat; Region: NHL; pfam01436 1121448005227 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 1121448005228 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 1121448005229 catalytic residues [active] 1121448005230 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 1121448005231 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 1121448005232 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1121448005233 3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353 1121448005234 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 1121448005235 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 1121448005236 AmmeMemoRadiSam system protein A; Region: AmmeMemoSam_A; TIGR04335 1121448005237 AMMECR1; Region: AMMECR1; pfam01871 1121448005238 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 1121448005239 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 1121448005240 active site 1121448005241 substrate binding site [chemical binding]; other site 1121448005242 cosubstrate binding site; other site 1121448005243 catalytic site [active] 1121448005244 Diphthamide biosynthesis methyltransferase [Translation, ribosomal structure and biogenesis]; Region: DPH5; COG1798 1121448005245 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1121448005246 active site 1121448005247 SAM binding site [chemical binding]; other site 1121448005248 homodimer interface [polypeptide binding]; other site 1121448005249 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 1121448005250 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1121448005251 active site 1121448005252 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 1121448005253 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1121448005254 HIGH motif; other site 1121448005255 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1121448005256 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1121448005257 active site 1121448005258 KMSKS motif; other site 1121448005259 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1121448005260 tRNA binding surface [nucleotide binding]; other site 1121448005261 anticodon binding site; other site 1121448005262 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 1121448005263 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1121448005264 NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691 1121448005265 AIR carboxylase; Region: AIRC; smart01001 1121448005266 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1121448005267 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121448005268 active site 1121448005269 phosphorylation site [posttranslational modification] 1121448005270 intermolecular recognition site; other site 1121448005271 dimerization interface [polypeptide binding]; other site 1121448005272 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1121448005273 Walker A motif; other site 1121448005274 ATP binding site [chemical binding]; other site 1121448005275 Walker B motif; other site 1121448005276 arginine finger; other site 1121448005277 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1121448005278 aspartate aminotransferase; Provisional; Region: PRK06836 1121448005279 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1121448005280 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1121448005281 homodimer interface [polypeptide binding]; other site 1121448005282 catalytic residue [active] 1121448005283 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1121448005284 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 1121448005285 Protein of unknown function (DUF3995); Region: DUF3995; pfam13160 1121448005286 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1121448005287 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1121448005288 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1121448005289 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074 1121448005290 Family description; Region: UvrD_C_2; pfam13538 1121448005291 Domain of unknown function (DUF309); Region: DUF309; pfam03745 1121448005292 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 1121448005293 putative CheA interaction surface; other site 1121448005294 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 1121448005295 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 1121448005296 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1121448005297 ATP binding site [chemical binding]; other site 1121448005298 putative Mg++ binding site [ion binding]; other site 1121448005299 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1121448005300 nucleotide binding region [chemical binding]; other site 1121448005301 ATP-binding site [chemical binding]; other site 1121448005302 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 1121448005303 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 1121448005304 SurA N-terminal domain; Region: SurA_N; pfam09312 1121448005305 SurA N-terminal domain; Region: SurA_N_3; cl07813 1121448005306 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1121448005307 Helix-turn-helix domain; Region: HTH_25; pfam13413 1121448005308 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 1121448005309 Recombination protein O N terminal; Region: RecO_N; pfam11967 1121448005310 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 1121448005311 dimer interface [polypeptide binding]; other site 1121448005312 motif 1; other site 1121448005313 active site 1121448005314 motif 2; other site 1121448005315 motif 3; other site 1121448005316 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 1121448005317 Domain of unknown function (DUF364); Region: DUF364; pfam04016 1121448005318 Putative methyltransferase; Region: Methyltransf_16; pfam10294 1121448005319 putative methanogenesis marker protein 1; Region: methan_mark_1; TIGR03266 1121448005320 YcaO-like family; Region: YcaO; pfam02624 1121448005321 TPR repeat; Region: TPR_11; pfam13414 1121448005322 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1121448005323 binding surface 1121448005324 TPR motif; other site 1121448005325 TPR repeat; Region: TPR_11; pfam13414 1121448005326 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920 1121448005327 DsrC like protein; Region: DsrC; pfam04358 1121448005328 peroxiredoxin; Region: AhpC; TIGR03137 1121448005329 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1121448005330 dimer interface [polypeptide binding]; other site 1121448005331 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1121448005332 catalytic triad [active] 1121448005333 peroxidatic and resolving cysteines [active] 1121448005334 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1121448005335 metal ion-dependent adhesion site (MIDAS); other site 1121448005336 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1121448005337 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1121448005338 ligand binding site [chemical binding]; other site 1121448005339 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 1121448005340 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1121448005341 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1121448005342 putative oxidoreductase; Provisional; Region: PRK12831 1121448005343 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1121448005344 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002 1121448005345 ferredoxin-NADP(+) reductase subunit alpha; Reviewed; Region: PRK06222 1121448005346 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)...; Region: DHOD_e_trans_like1; cd06219 1121448005347 FAD binding pocket [chemical binding]; other site 1121448005348 FAD binding motif [chemical binding]; other site 1121448005349 phosphate binding motif [ion binding]; other site 1121448005350 beta-alpha-beta structure motif; other site 1121448005351 NAD binding pocket [chemical binding]; other site 1121448005352 Iron coordination center [ion binding]; other site 1121448005353 Cache domain; Region: Cache_1; pfam02743 1121448005354 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1121448005355 dimerization interface [polypeptide binding]; other site 1121448005356 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1121448005357 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1121448005358 dimer interface [polypeptide binding]; other site 1121448005359 putative CheW interface [polypeptide binding]; other site 1121448005360 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1121448005361 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1121448005362 metal binding site [ion binding]; metal-binding site 1121448005363 active site 1121448005364 I-site; other site 1121448005365 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 1121448005366 active site 1121448005367 zinc binding site [ion binding]; other site 1121448005368 Na+ binding site [ion binding]; other site 1121448005369 Uncharacterized conserved protein [Function unknown]; Region: COG1433 1121448005370 Response regulator receiver domain; Region: Response_reg; pfam00072 1121448005371 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121448005372 active site 1121448005373 phosphorylation site [posttranslational modification] 1121448005374 intermolecular recognition site; other site 1121448005375 dimerization interface [polypeptide binding]; other site 1121448005376 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 1121448005377 heme-binding residues [chemical binding]; other site 1121448005378 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1121448005379 Cysteine-rich domain; Region: CCG; pfam02754 1121448005380 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959 1121448005381 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 1121448005382 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121448005383 PAS domain; Region: PAS_9; pfam13426 1121448005384 putative active site [active] 1121448005385 heme pocket [chemical binding]; other site 1121448005386 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 1121448005387 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1121448005388 Walker A motif; other site 1121448005389 ATP binding site [chemical binding]; other site 1121448005390 Walker B motif; other site 1121448005391 arginine finger; other site 1121448005392 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1121448005393 dimerization interface [polypeptide binding]; other site 1121448005394 PAS fold; Region: PAS_4; pfam08448 1121448005395 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1121448005396 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121448005397 putative active site [active] 1121448005398 heme pocket [chemical binding]; other site 1121448005399 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1121448005400 dimer interface [polypeptide binding]; other site 1121448005401 phosphorylation site [posttranslational modification] 1121448005402 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121448005403 ATP binding site [chemical binding]; other site 1121448005404 Mg2+ binding site [ion binding]; other site 1121448005405 G-X-G motif; other site 1121448005406 Response regulator receiver domain; Region: Response_reg; pfam00072 1121448005407 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121448005408 active site 1121448005409 phosphorylation site [posttranslational modification] 1121448005410 intermolecular recognition site; other site 1121448005411 dimerization interface [polypeptide binding]; other site 1121448005412 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121448005413 ATP binding site [chemical binding]; other site 1121448005414 Mg2+ binding site [ion binding]; other site 1121448005415 G-X-G motif; other site 1121448005416 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1121448005417 Ligand Binding Site [chemical binding]; other site 1121448005418 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1121448005419 Ligand Binding Site [chemical binding]; other site 1121448005420 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1121448005421 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121448005422 active site 1121448005423 phosphorylation site [posttranslational modification] 1121448005424 intermolecular recognition site; other site 1121448005425 Response regulator receiver domain; Region: Response_reg; pfam00072 1121448005426 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121448005427 active site 1121448005428 phosphorylation site [posttranslational modification] 1121448005429 intermolecular recognition site; other site 1121448005430 dimerization interface [polypeptide binding]; other site 1121448005431 PAS fold; Region: PAS_4; pfam08448 1121448005432 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1121448005433 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121448005434 ATP binding site [chemical binding]; other site 1121448005435 G-X-G motif; other site 1121448005436 Vi polysaccharide biosynthesis protein TviC; Provisional; Region: PRK15181 1121448005437 UDP-N-acetylglucosamine 4-epimerase, extended (e) SDRs; Region: UDP_AE_SDR_e; cd05256 1121448005438 NAD binding site [chemical binding]; other site 1121448005439 substrate binding site [chemical binding]; other site 1121448005440 homodimer interface [polypeptide binding]; other site 1121448005441 active site 1121448005442 Predicted transcriptional regulator [Transcription]; Region: COG2932 1121448005443 Bacteriophage CI repressor helix-turn-helix domain; Region: Phage_CI_repr; pfam07022 1121448005444 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1121448005445 Catalytic site [active] 1121448005446 2-oxoacid ferredoxin oxidoreductase subunit beta; Provisional; Region: PRK11869 1121448005447 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 1121448005448 TPP-binding site [chemical binding]; other site 1121448005449 Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367 1121448005450 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 1121448005451 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; pfam01558 1121448005452 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 1121448005453 dimer interface [polypeptide binding]; other site 1121448005454 PYR/PP interface [polypeptide binding]; other site 1121448005455 TPP binding site [chemical binding]; other site 1121448005456 substrate binding site [chemical binding]; other site 1121448005457 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1121448005458 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 1121448005459 dinuclear metal binding motif [ion binding]; other site 1121448005460 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 1121448005461 Ferritin-like domain; Region: Ferritin; pfam00210 1121448005462 ferroxidase diiron center [ion binding]; other site 1121448005463 conserved hypothetical protein; Region: TIGR02285 1121448005464 Deoxyhypusine synthase; Region: DS; cl00826 1121448005465 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1121448005466 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1121448005467 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1121448005468 non-specific DNA binding site [nucleotide binding]; other site 1121448005469 salt bridge; other site 1121448005470 sequence-specific DNA binding site [nucleotide binding]; other site 1121448005471 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121448005472 PAS domain; Region: PAS_9; pfam13426 1121448005473 putative active site [active] 1121448005474 heme pocket [chemical binding]; other site 1121448005475 diaminopimelate decarboxylase; Region: lysA; TIGR01048 1121448005476 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1121448005477 active site 1121448005478 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1121448005479 substrate binding site [chemical binding]; other site 1121448005480 catalytic residues [active] 1121448005481 dimer interface [polypeptide binding]; other site 1121448005482 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 1121448005483 MutS domain I; Region: MutS_I; pfam01624 1121448005484 MutS domain II; Region: MutS_II; pfam05188 1121448005485 MutS domain III; Region: MutS_III; pfam05192 1121448005486 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 1121448005487 Walker A/P-loop; other site 1121448005488 ATP binding site [chemical binding]; other site 1121448005489 Q-loop/lid; other site 1121448005490 ABC transporter signature motif; other site 1121448005491 Walker B; other site 1121448005492 D-loop; other site 1121448005493 H-loop/switch region; other site 1121448005494 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1121448005495 binding surface 1121448005496 TPR motif; other site 1121448005497 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 1121448005498 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1121448005499 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 1121448005500 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 1121448005501 catalytic residues [active] 1121448005502 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 1121448005503 putative active site pocket [active] 1121448005504 4-fold oligomerization interface [polypeptide binding]; other site 1121448005505 metal binding residues [ion binding]; metal-binding site 1121448005506 3-fold/trimer interface [polypeptide binding]; other site 1121448005507 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 1121448005508 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1121448005509 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 1121448005510 PSP1 C-terminal conserved region; Region: PSP1; cl00770 1121448005511 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 1121448005512 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1121448005513 active site 1121448005514 HIGH motif; other site 1121448005515 KMSKS motif; other site 1121448005516 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1121448005517 tRNA binding surface [nucleotide binding]; other site 1121448005518 anticodon binding site; other site 1121448005519 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 1121448005520 dimer interface [polypeptide binding]; other site 1121448005521 putative tRNA-binding site [nucleotide binding]; other site 1121448005522 acetyl-CoA synthetase; Provisional; Region: PRK00174 1121448005523 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 1121448005524 active site 1121448005525 CoA binding site [chemical binding]; other site 1121448005526 acyl-activating enzyme (AAE) consensus motif; other site 1121448005527 AMP binding site [chemical binding]; other site 1121448005528 acetate binding site [chemical binding]; other site 1121448005529 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 1121448005530 LytTr DNA-binding domain; Region: LytTR; smart00850 1121448005531 GTP-binding protein Der; Reviewed; Region: PRK00093 1121448005532 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1121448005533 G1 box; other site 1121448005534 GTP/Mg2+ binding site [chemical binding]; other site 1121448005535 Switch I region; other site 1121448005536 G2 box; other site 1121448005537 Switch II region; other site 1121448005538 G3 box; other site 1121448005539 G4 box; other site 1121448005540 G5 box; other site 1121448005541 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1121448005542 G1 box; other site 1121448005543 GTP/Mg2+ binding site [chemical binding]; other site 1121448005544 Switch I region; other site 1121448005545 G2 box; other site 1121448005546 G3 box; other site 1121448005547 Switch II region; other site 1121448005548 G4 box; other site 1121448005549 G5 box; other site 1121448005550 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348 1121448005551 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 1121448005552 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 1121448005553 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 1121448005554 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 1121448005555 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 1121448005556 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 1121448005557 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 1121448005558 GatB domain; Region: GatB_Yqey; smart00845 1121448005559 PilZ domain; Region: PilZ; pfam07238 1121448005560 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1121448005561 catalytic core [active] 1121448005562 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1121448005563 thiamine biosynthesis protein ThiC; Provisional; Region: PRK13352 1121448005564 thiamine biosynthesis protein ThiC; Region: thiC; TIGR00190 1121448005565 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 1121448005566 Protein of unknown function (DUF1385); Region: DUF1385; pfam07136 1121448005567 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1121448005568 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1121448005569 RF-1 domain; Region: RF-1; pfam00472 1121448005570 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 1121448005571 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1121448005572 S-adenosylmethionine binding site [chemical binding]; other site 1121448005573 elongation factor Tu; Reviewed; Region: PRK00049 1121448005574 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1121448005575 G1 box; other site 1121448005576 GEF interaction site [polypeptide binding]; other site 1121448005577 GTP/Mg2+ binding site [chemical binding]; other site 1121448005578 Switch I region; other site 1121448005579 G2 box; other site 1121448005580 G3 box; other site 1121448005581 Switch II region; other site 1121448005582 G4 box; other site 1121448005583 G5 box; other site 1121448005584 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1121448005585 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1121448005586 Antibiotic Binding Site [chemical binding]; other site 1121448005587 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 1121448005588 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584 1121448005589 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1121448005590 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1121448005591 putative homodimer interface [polypeptide binding]; other site 1121448005592 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1121448005593 heterodimer interface [polypeptide binding]; other site 1121448005594 homodimer interface [polypeptide binding]; other site 1121448005595 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1121448005596 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1121448005597 23S rRNA interface [nucleotide binding]; other site 1121448005598 L7/L12 interface [polypeptide binding]; other site 1121448005599 putative thiostrepton binding site; other site 1121448005600 L25 interface [polypeptide binding]; other site 1121448005601 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1121448005602 mRNA/rRNA interface [nucleotide binding]; other site 1121448005603 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1121448005604 23S rRNA interface [nucleotide binding]; other site 1121448005605 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1121448005606 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1121448005607 peripheral dimer interface [polypeptide binding]; other site 1121448005608 core dimer interface [polypeptide binding]; other site 1121448005609 L10 interface [polypeptide binding]; other site 1121448005610 L11 interface [polypeptide binding]; other site 1121448005611 putative EF-Tu interaction site [polypeptide binding]; other site 1121448005612 putative EF-G interaction site [polypeptide binding]; other site 1121448005613 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 1121448005614 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1121448005615 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 1121448005616 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1121448005617 RPB11 interaction site [polypeptide binding]; other site 1121448005618 RPB12 interaction site [polypeptide binding]; other site 1121448005619 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1121448005620 RPB3 interaction site [polypeptide binding]; other site 1121448005621 RPB1 interaction site [polypeptide binding]; other site 1121448005622 RPB11 interaction site [polypeptide binding]; other site 1121448005623 RPB10 interaction site [polypeptide binding]; other site 1121448005624 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1121448005625 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 1121448005626 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1121448005627 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1121448005628 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1121448005629 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 1121448005630 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 1121448005631 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 1121448005632 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 1121448005633 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1121448005634 DNA binding site [nucleotide binding] 1121448005635 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1121448005636 GTP-binding protein LepA; Provisional; Region: PRK05433 1121448005637 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1121448005638 G1 box; other site 1121448005639 putative GEF interaction site [polypeptide binding]; other site 1121448005640 GTP/Mg2+ binding site [chemical binding]; other site 1121448005641 Switch I region; other site 1121448005642 G2 box; other site 1121448005643 G3 box; other site 1121448005644 Switch II region; other site 1121448005645 G4 box; other site 1121448005646 G5 box; other site 1121448005647 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 1121448005648 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1121448005649 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1121448005650 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1121448005651 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1121448005652 Catalytic site [active] 1121448005653 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 1121448005654 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1121448005655 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1121448005656 Walker A motif; other site 1121448005657 ATP binding site [chemical binding]; other site 1121448005658 Walker B motif; other site 1121448005659 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 1121448005660 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 1121448005661 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 1121448005662 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 1121448005663 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 1121448005664 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 1121448005665 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1121448005666 active site residue [active] 1121448005667 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cl01482 1121448005668 dimer interface [polypeptide binding]; other site 1121448005669 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 1121448005670 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 1121448005671 hexamer interface [polypeptide binding]; other site 1121448005672 ligand binding site [chemical binding]; other site 1121448005673 putative active site [active] 1121448005674 NAD(P) binding site [chemical binding]; other site 1121448005675 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 1121448005676 Phosphate ATP-binding cassette transporter; Region: DUF3708; pfam12501 1121448005677 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 1121448005678 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121448005679 dimer interface [polypeptide binding]; other site 1121448005680 conserved gate region; other site 1121448005681 putative PBP binding loops; other site 1121448005682 ABC-ATPase subunit interface; other site 1121448005683 Domain of unknown function (DUF3333); Region: DUF3333; pfam11812 1121448005684 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 1121448005685 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121448005686 dimer interface [polypeptide binding]; other site 1121448005687 conserved gate region; other site 1121448005688 putative PBP binding loops; other site 1121448005689 ABC-ATPase subunit interface; other site 1121448005690 ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226 1121448005691 phosphate transporter ATP-binding protein; Provisional; Region: PRK14235 1121448005692 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1121448005693 Walker A/P-loop; other site 1121448005694 ATP binding site [chemical binding]; other site 1121448005695 Q-loop/lid; other site 1121448005696 ABC transporter signature motif; other site 1121448005697 Walker B; other site 1121448005698 D-loop; other site 1121448005699 H-loop/switch region; other site 1121448005700 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 1121448005701 PhoU domain; Region: PhoU; pfam01895 1121448005702 PhoU domain; Region: PhoU; pfam01895 1121448005703 putative GTP cyclohydrolase; Provisional; Region: PRK13674 1121448005704 Predicted Zn-ribbon RNA-binding protein with a function in translation [Translation, ribosomal structure and biogenesis]; Region: COG2888 1121448005705 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 1121448005706 PilZ domain; Region: PilZ; pfam07238 1121448005707 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 1121448005708 ATP-grasp domain; Region: ATP-grasp; pfam02222 1121448005709 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1121448005710 DsrE/DsrF-like family; Region: DrsE; pfam02635 1121448005711 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1121448005712 PAS domain; Region: PAS_9; pfam13426 1121448005713 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1121448005714 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121448005715 putative active site [active] 1121448005716 heme pocket [chemical binding]; other site 1121448005717 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1121448005718 dimer interface [polypeptide binding]; other site 1121448005719 phosphorylation site [posttranslational modification] 1121448005720 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121448005721 ATP binding site [chemical binding]; other site 1121448005722 Mg2+ binding site [ion binding]; other site 1121448005723 G-X-G motif; other site 1121448005724 Response regulator receiver domain; Region: Response_reg; pfam00072 1121448005725 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121448005726 active site 1121448005727 phosphorylation site [posttranslational modification] 1121448005728 intermolecular recognition site; other site 1121448005729 dimerization interface [polypeptide binding]; other site 1121448005730 PAS domain; Region: PAS_9; pfam13426 1121448005731 PAS domain; Region: PAS_9; pfam13426 1121448005732 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121448005733 putative active site [active] 1121448005734 heme pocket [chemical binding]; other site 1121448005735 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1121448005736 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121448005737 ATP binding site [chemical binding]; other site 1121448005738 Mg2+ binding site [ion binding]; other site 1121448005739 G-X-G motif; other site 1121448005740 Response regulator receiver domain; Region: Response_reg; pfam00072 1121448005741 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121448005742 active site 1121448005743 phosphorylation site [posttranslational modification] 1121448005744 intermolecular recognition site; other site 1121448005745 dimerization interface [polypeptide binding]; other site 1121448005746 Protein of unknown function (DUF1641); Region: DUF1641; pfam07849 1121448005747 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 1121448005748 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1121448005749 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121448005750 active site 1121448005751 phosphorylation site [posttranslational modification] 1121448005752 intermolecular recognition site; other site 1121448005753 dimerization interface [polypeptide binding]; other site 1121448005754 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1121448005755 Walker A motif; other site 1121448005756 ATP binding site [chemical binding]; other site 1121448005757 Walker B motif; other site 1121448005758 arginine finger; other site 1121448005759 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1121448005760 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1121448005761 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1121448005762 putative active site [active] 1121448005763 heme pocket [chemical binding]; other site 1121448005764 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121448005765 putative active site [active] 1121448005766 heme pocket [chemical binding]; other site 1121448005767 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 1121448005768 dimer interface [polypeptide binding]; other site 1121448005769 phosphorylation site [posttranslational modification] 1121448005770 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121448005771 ATP binding site [chemical binding]; other site 1121448005772 Mg2+ binding site [ion binding]; other site 1121448005773 G-X-G motif; other site 1121448005774 HAMP domain; Region: HAMP; pfam00672 1121448005775 dimerization interface [polypeptide binding]; other site 1121448005776 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121448005777 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1121448005778 putative active site [active] 1121448005779 heme pocket [chemical binding]; other site 1121448005780 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1121448005781 dimer interface [polypeptide binding]; other site 1121448005782 phosphorylation site [posttranslational modification] 1121448005783 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121448005784 ATP binding site [chemical binding]; other site 1121448005785 Mg2+ binding site [ion binding]; other site 1121448005786 G-X-G motif; other site 1121448005787 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121448005788 Response regulator receiver domain; Region: Response_reg; pfam00072 1121448005789 active site 1121448005790 phosphorylation site [posttranslational modification] 1121448005791 intermolecular recognition site; other site 1121448005792 dimerization interface [polypeptide binding]; other site 1121448005793 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1121448005794 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1121448005795 putative substrate translocation pore; other site 1121448005796 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 1121448005797 tetramer interfaces [polypeptide binding]; other site 1121448005798 binuclear metal-binding site [ion binding]; other site 1121448005799 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1121448005800 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1121448005801 dimer interface [polypeptide binding]; other site 1121448005802 phosphorylation site [posttranslational modification] 1121448005803 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121448005804 ATP binding site [chemical binding]; other site 1121448005805 Mg2+ binding site [ion binding]; other site 1121448005806 G-X-G motif; other site 1121448005807 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1121448005808 active site 1121448005809 catalytic triad [active] 1121448005810 oxyanion hole [active] 1121448005811 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1121448005812 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 1121448005813 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1121448005814 active site 1121448005815 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 1121448005816 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 1121448005817 putative ligand binding site [chemical binding]; other site 1121448005818 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1121448005819 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1121448005820 TM-ABC transporter signature motif; other site 1121448005821 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1121448005822 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1121448005823 TM-ABC transporter signature motif; other site 1121448005824 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 1121448005825 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1121448005826 Walker A/P-loop; other site 1121448005827 ATP binding site [chemical binding]; other site 1121448005828 Q-loop/lid; other site 1121448005829 ABC transporter signature motif; other site 1121448005830 Walker B; other site 1121448005831 D-loop; other site 1121448005832 H-loop/switch region; other site 1121448005833 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1121448005834 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1121448005835 Phosphotransferase enzyme family; Region: APH; pfam01636 1121448005836 active site 1121448005837 ATP binding site [chemical binding]; other site 1121448005838 substrate binding site [chemical binding]; other site 1121448005839 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1121448005840 active site 1121448005841 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14337 1121448005842 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1121448005843 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1121448005844 FeS/SAM binding site; other site 1121448005845 Bifunctional nuclease; Region: DNase-RNase; pfam02577 1121448005846 hypothetical protein; Provisional; Region: PRK06361 1121448005847 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 1121448005848 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 1121448005849 tRNA synthetases class I (E and Q), catalytic domain; Region: tRNA-synt_1c; pfam00749 1121448005850 active site 1121448005851 HIGH motif; other site 1121448005852 nucleotide binding site [chemical binding]; other site 1121448005853 active site 1121448005854 KMSKS motif; other site 1121448005855 Peptidase M1 family containing bacterial Aminopeptidase N; Region: M1_APN_5; cd09604 1121448005856 Zn binding site [ion binding]; other site 1121448005857 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121448005858 putative active site [active] 1121448005859 PAS fold; Region: PAS_3; pfam08447 1121448005860 heme pocket [chemical binding]; other site 1121448005861 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1121448005862 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1121448005863 dimer interface [polypeptide binding]; other site 1121448005864 phosphorylation site [posttranslational modification] 1121448005865 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121448005866 ATP binding site [chemical binding]; other site 1121448005867 Mg2+ binding site [ion binding]; other site 1121448005868 G-X-G motif; other site 1121448005869 Response regulator receiver domain; Region: Response_reg; pfam00072 1121448005870 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121448005871 active site 1121448005872 phosphorylation site [posttranslational modification] 1121448005873 intermolecular recognition site; other site 1121448005874 dimerization interface [polypeptide binding]; other site 1121448005875 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1121448005876 putative binding surface; other site 1121448005877 active site 1121448005878 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1121448005879 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1121448005880 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1121448005881 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1121448005882 Peptidase C25 family N-terminal domain, found in Arg-gingipain (Rgp), Lys-gingipain (Kgp) and related proteins; Region: Peptidase_C25_N; cl03181 1121448005883 active site 1121448005884 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1121448005885 Walker B; other site 1121448005886 D-loop; other site 1121448005887 H-loop/switch region; other site 1121448005888 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1121448005889 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1121448005890 active site 1121448005891 metal binding site [ion binding]; metal-binding site 1121448005892 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1121448005893 AAA domain; Region: AAA_23; pfam13476 1121448005894 Walker A/P-loop; other site 1121448005895 ATP binding site [chemical binding]; other site 1121448005896 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 1121448005897 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 1121448005898 isocitrate dehydrogenase; Validated; Region: PRK07362 1121448005899 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 1121448005900 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1121448005901 active site 1121448005902 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121448005903 PAS domain; Region: PAS_9; pfam13426 1121448005904 putative active site [active] 1121448005905 heme pocket [chemical binding]; other site 1121448005906 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121448005907 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1121448005908 putative active site [active] 1121448005909 heme pocket [chemical binding]; other site 1121448005910 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121448005911 putative active site [active] 1121448005912 heme pocket [chemical binding]; other site 1121448005913 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1121448005914 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1121448005915 metal binding site [ion binding]; metal-binding site 1121448005916 active site 1121448005917 I-site; other site 1121448005918 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1121448005919 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1121448005920 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1121448005921 Walker A/P-loop; other site 1121448005922 ATP binding site [chemical binding]; other site 1121448005923 Q-loop/lid; other site 1121448005924 ABC transporter signature motif; other site 1121448005925 Walker B; other site 1121448005926 D-loop; other site 1121448005927 H-loop/switch region; other site 1121448005928 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1121448005929 Ligand Binding Site [chemical binding]; other site 1121448005930 selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512 1121448005931 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 1121448005932 G1 box; other site 1121448005933 putative GEF interaction site [polypeptide binding]; other site 1121448005934 GTP/Mg2+ binding site [chemical binding]; other site 1121448005935 Switch I region; other site 1121448005936 G2 box; other site 1121448005937 G3 box; other site 1121448005938 Switch II region; other site 1121448005939 G4 box; other site 1121448005940 G5 box; other site 1121448005941 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 1121448005942 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 1121448005943 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 1121448005944 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 1121448005945 M18 Peptidase Aminopeptidase I; Region: M18_API; cd05659 1121448005946 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 1121448005947 oligomer interface [polypeptide binding]; other site 1121448005948 putative active site [active] 1121448005949 metal binding site [ion binding]; metal-binding site 1121448005950 seryl-tRNA(sec) selenium transferase; Region: selA; TIGR00474 1121448005951 Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921 1121448005952 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1121448005953 catalytic residue [active] 1121448005954 folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499 1121448005955 Fic family protein [Function unknown]; Region: COG3177 1121448005956 Fic/DOC family; Region: Fic; pfam02661 1121448005957 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 1121448005958 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656 1121448005959 CRISPR/Cas system-associated protein Cas3/Cas2; Region: Cas3_Cas2_I-F; cd09673 1121448005960 CRISPR-associated helicase Cas3, subtype I-F/YPEST; Region: cas3_yersinia; TIGR02562 1121448005961 CRISPR/Cas system-associated protein Csy1; Region: Csy1_I-F; cl09829 1121448005962 CRISPR/Cas system-associated RAMP superfamily protein Csy2; Region: Csy2_I-F; cd09736 1121448005963 CRISPR/Cas system-associated RAMP superfamily protein Csy3; Region: Csy3_I-F; cd09737 1121448005964 CRISPR/Cas system-associated RAMP superfamily protein Cas6f; Region: Cas6_I-F; cd09739 1121448005965 Response regulator receiver domain; Region: Response_reg; pfam00072 1121448005966 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121448005967 active site 1121448005968 phosphorylation site [posttranslational modification] 1121448005969 intermolecular recognition site; other site 1121448005970 dimerization interface [polypeptide binding]; other site 1121448005971 Response regulator receiver domain; Region: Response_reg; pfam00072 1121448005972 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121448005973 active site 1121448005974 phosphorylation site [posttranslational modification] 1121448005975 intermolecular recognition site; other site 1121448005976 dimerization interface [polypeptide binding]; other site 1121448005977 PAS domain; Region: PAS_9; pfam13426 1121448005978 PAS domain; Region: PAS_9; pfam13426 1121448005979 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121448005980 putative active site [active] 1121448005981 heme pocket [chemical binding]; other site 1121448005982 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1121448005983 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121448005984 ATP binding site [chemical binding]; other site 1121448005985 Mg2+ binding site [ion binding]; other site 1121448005986 G-X-G motif; other site 1121448005987 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1121448005988 PAS domain; Region: PAS_9; pfam13426 1121448005989 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1121448005990 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121448005991 putative active site [active] 1121448005992 heme pocket [chemical binding]; other site 1121448005993 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1121448005994 dimer interface [polypeptide binding]; other site 1121448005995 phosphorylation site [posttranslational modification] 1121448005996 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121448005997 ATP binding site [chemical binding]; other site 1121448005998 Mg2+ binding site [ion binding]; other site 1121448005999 G-X-G motif; other site 1121448006000 DsrE/DsrF-like family; Region: DrsE; pfam02635 1121448006001 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1121448006002 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 1121448006003 ATP-grasp domain; Region: ATP-grasp; pfam02222 1121448006004 Predicted Zn-ribbon RNA-binding protein with a function in translation [Translation, ribosomal structure and biogenesis]; Region: COG2888 1121448006005 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 1121448006006 PilZ domain; Region: PilZ; pfam07238 1121448006007 putative GTP cyclohydrolase; Provisional; Region: PRK13674 1121448006008 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 1121448006009 PhoU domain; Region: PhoU; pfam01895 1121448006010 PhoU domain; Region: PhoU; pfam01895 1121448006011 phosphate transporter ATP-binding protein; Provisional; Region: PRK14235 1121448006012 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1121448006013 Walker A/P-loop; other site 1121448006014 ATP binding site [chemical binding]; other site 1121448006015 Q-loop/lid; other site 1121448006016 ABC transporter signature motif; other site 1121448006017 Walker B; other site 1121448006018 D-loop; other site 1121448006019 H-loop/switch region; other site 1121448006020 ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226 1121448006021 Domain of unknown function (DUF3333); Region: DUF3333; pfam11812 1121448006022 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 1121448006023 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121448006024 dimer interface [polypeptide binding]; other site 1121448006025 conserved gate region; other site 1121448006026 putative PBP binding loops; other site 1121448006027 ABC-ATPase subunit interface; other site 1121448006028 Phosphate ATP-binding cassette transporter; Region: DUF3708; pfam12501 1121448006029 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 1121448006030 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121448006031 dimer interface [polypeptide binding]; other site 1121448006032 conserved gate region; other site 1121448006033 putative PBP binding loops; other site 1121448006034 ABC-ATPase subunit interface; other site 1121448006035 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 1121448006036 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 1121448006037 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 1121448006038 hexamer interface [polypeptide binding]; other site 1121448006039 ligand binding site [chemical binding]; other site 1121448006040 putative active site [active] 1121448006041 NAD(P) binding site [chemical binding]; other site 1121448006042 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257 1121448006043 GIY-YIG motif/motif A; other site 1121448006044 active site 1121448006045 catalytic site [active] 1121448006046 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 1121448006047 Found in ATP-dependent protease La (LON); Region: LON; smart00464 1121448006048 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1121448006049 Walker A motif; other site 1121448006050 ATP binding site [chemical binding]; other site 1121448006051 Walker B motif; other site 1121448006052 arginine finger; other site 1121448006053 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1121448006054 Acylphosphatase; Region: Acylphosphatase; pfam00708 1121448006055 hypothetical protein; Reviewed; Region: PRK00024 1121448006056 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 1121448006057 MPN+ (JAMM) motif; other site 1121448006058 Zinc-binding site [ion binding]; other site 1121448006059 DNA polymerase III, delta subunit; Region: holA; TIGR01128 1121448006060 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1121448006061 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1121448006062 HIGH motif; other site 1121448006063 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1121448006064 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1121448006065 active site 1121448006066 KMSKS motif; other site 1121448006067 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1121448006068 tRNA binding surface [nucleotide binding]; other site 1121448006069 transcription antitermination factor NusB; Region: nusB; TIGR01951 1121448006070 putative RNA binding site [nucleotide binding]; other site 1121448006071 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 1121448006072 homopentamer interface [polypeptide binding]; other site 1121448006073 active site 1121448006074 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 1121448006075 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 1121448006076 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 1121448006077 dimerization interface [polypeptide binding]; other site 1121448006078 active site 1121448006079 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 1121448006080 Lumazine binding domain; Region: Lum_binding; pfam00677 1121448006081 Lumazine binding domain; Region: Lum_binding; pfam00677 1121448006082 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 1121448006083 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 1121448006084 catalytic motif [active] 1121448006085 Zn binding site [ion binding]; other site 1121448006086 RibD C-terminal domain; Region: RibD_C; cl17279 1121448006087 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 1121448006088 catalytic motif [active] 1121448006089 Zn binding site [ion binding]; other site 1121448006090 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1121448006091 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1121448006092 dimer interface [polypeptide binding]; other site 1121448006093 active site 1121448006094 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1121448006095 folate binding site [chemical binding]; other site 1121448006096 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 1121448006097 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1121448006098 dimer interface [polypeptide binding]; other site 1121448006099 active site 1121448006100 acyl carrier protein; Provisional; Region: acpP; PRK00982 1121448006101 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1121448006102 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 1121448006103 NAD(P) binding site [chemical binding]; other site 1121448006104 homotetramer interface [polypeptide binding]; other site 1121448006105 homodimer interface [polypeptide binding]; other site 1121448006106 active site 1121448006107 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 1121448006108 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1121448006109 dimer interface [polypeptide binding]; other site 1121448006110 active site 1121448006111 CoA binding pocket [chemical binding]; other site 1121448006112 putative phosphate acyltransferase; Provisional; Region: PRK05331 1121448006113 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 1121448006114 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 1121448006115 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1121448006116 FxsA cytoplasmic membrane protein; Region: FxsA; pfam04186 1121448006117 Rhomboid family; Region: Rhomboid; pfam01694 1121448006118 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 1121448006119 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 1121448006120 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1121448006121 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1121448006122 dimer interface [polypeptide binding]; other site 1121448006123 phosphorylation site [posttranslational modification] 1121448006124 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121448006125 ATP binding site [chemical binding]; other site 1121448006126 Mg2+ binding site [ion binding]; other site 1121448006127 G-X-G motif; other site 1121448006128 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1121448006129 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1121448006130 substrate binding pocket [chemical binding]; other site 1121448006131 membrane-bound complex binding site; other site 1121448006132 hinge residues; other site 1121448006133 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121448006134 dimer interface [polypeptide binding]; other site 1121448006135 conserved gate region; other site 1121448006136 putative PBP binding loops; other site 1121448006137 ABC-ATPase subunit interface; other site 1121448006138 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 1121448006139 catalytic residues [active] 1121448006140 Ferredoxin thioredoxin reductase catalytic beta chain; Region: FeThRed_B; cl01977 1121448006141 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1121448006142 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 1121448006143 active site 1121448006144 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 1121448006145 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1121448006146 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121448006147 dimer interface [polypeptide binding]; other site 1121448006148 conserved gate region; other site 1121448006149 putative PBP binding loops; other site 1121448006150 ABC-ATPase subunit interface; other site 1121448006151 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 1121448006152 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 1121448006153 Walker A/P-loop; other site 1121448006154 ATP binding site [chemical binding]; other site 1121448006155 Q-loop/lid; other site 1121448006156 ABC transporter signature motif; other site 1121448006157 Walker B; other site 1121448006158 D-loop; other site 1121448006159 H-loop/switch region; other site 1121448006160 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1121448006161 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1121448006162 PAS domain; Region: PAS; smart00091 1121448006163 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1121448006164 phosphorylation site [posttranslational modification] 1121448006165 dimer interface [polypeptide binding]; other site 1121448006166 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121448006167 ATP binding site [chemical binding]; other site 1121448006168 G-X-G motif; other site 1121448006169 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1121448006170 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121448006171 active site 1121448006172 phosphorylation site [posttranslational modification] 1121448006173 intermolecular recognition site; other site 1121448006174 dimerization interface [polypeptide binding]; other site 1121448006175 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1121448006176 Walker A motif; other site 1121448006177 ATP binding site [chemical binding]; other site 1121448006178 Walker B motif; other site 1121448006179 arginine finger; other site 1121448006180 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1121448006181 CheW-like domain; Region: CheW; pfam01584 1121448006182 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 1121448006183 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 1121448006184 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1121448006185 TPR motif; other site 1121448006186 binding surface 1121448006187 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 1121448006188 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 1121448006189 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1121448006190 dimerization interface [polypeptide binding]; other site 1121448006191 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1121448006192 dimer interface [polypeptide binding]; other site 1121448006193 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 1121448006194 putative CheW interface [polypeptide binding]; other site 1121448006195 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 1121448006196 putative binding surface; other site 1121448006197 active site 1121448006198 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121448006199 ATP binding site [chemical binding]; other site 1121448006200 Mg2+ binding site [ion binding]; other site 1121448006201 G-X-G motif; other site 1121448006202 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1121448006203 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121448006204 active site 1121448006205 phosphorylation site [posttranslational modification] 1121448006206 intermolecular recognition site; other site 1121448006207 dimerization interface [polypeptide binding]; other site 1121448006208 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 1121448006209 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121448006210 active site 1121448006211 phosphorylation site [posttranslational modification] 1121448006212 intermolecular recognition site; other site 1121448006213 dimerization interface [polypeptide binding]; other site 1121448006214 CheB methylesterase; Region: CheB_methylest; pfam01339 1121448006215 Response regulator receiver domain; Region: Response_reg; pfam00072 1121448006216 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121448006217 active site 1121448006218 phosphorylation site [posttranslational modification] 1121448006219 intermolecular recognition site; other site 1121448006220 dimerization interface [polypeptide binding]; other site 1121448006221 PAS fold; Region: PAS_4; pfam08448 1121448006222 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121448006223 putative active site [active] 1121448006224 heme pocket [chemical binding]; other site 1121448006225 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1121448006226 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1121448006227 dimer interface [polypeptide binding]; other site 1121448006228 phosphorylation site [posttranslational modification] 1121448006229 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121448006230 ATP binding site [chemical binding]; other site 1121448006231 Mg2+ binding site [ion binding]; other site 1121448006232 G-X-G motif; other site 1121448006233 Response regulator receiver domain; Region: Response_reg; pfam00072 1121448006234 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121448006235 active site 1121448006236 phosphorylation site [posttranslational modification] 1121448006237 intermolecular recognition site; other site 1121448006238 dimerization interface [polypeptide binding]; other site 1121448006239 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1121448006240 anti sigma factor interaction site; other site 1121448006241 regulatory phosphorylation site [posttranslational modification]; other site 1121448006242 CheD chemotactic sensory transduction; Region: CheD; cl00810 1121448006243 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1121448006244 Peptidase family M48; Region: Peptidase_M48; cl12018 1121448006245 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642 1121448006246 putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015 1121448006247 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1121448006248 Walker A motif; other site 1121448006249 ATP binding site [chemical binding]; other site 1121448006250 Walker B motif; other site 1121448006251 arginine finger; other site 1121448006252 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1121448006253 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1121448006254 ligand binding site [chemical binding]; other site 1121448006255 AAA domain; Region: AAA_31; pfam13614 1121448006256 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1121448006257 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 1121448006258 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 1121448006259 SLBB domain; Region: SLBB; pfam10531 1121448006260 Chain length determinant protein; Region: Wzz; pfam02706 1121448006261 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 1121448006262 Chain length determinant protein; Region: Wzz; cl15801 1121448006263 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1121448006264 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1121448006265 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1121448006266 active site 1121448006267 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 1121448006268 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 1121448006269 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1121448006270 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 1121448006271 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1121448006272 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1121448006273 DNA binding residues [nucleotide binding] 1121448006274 This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851 1121448006275 This protein family's function is unkown. It contains nucleotide binding site. It uses NTP as energy source to transfer electron or ion; Region: Fer4_NifH_child; cd03110 1121448006276 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 1121448006277 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 1121448006278 switch II; other site 1121448006279 This protein family's function is unkown. It contains nucleotide binding site. It uses NTP as energy source to transfer electron or ion; Region: Fer4_NifH_child; cd03110 1121448006280 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 1121448006281 switch II; other site 1121448006282 This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851 1121448006283 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 1121448006284 homodimer interaction site [polypeptide binding]; other site 1121448006285 cofactor binding site; other site 1121448006286 glycine dehydrogenase subunit 2; Validated; Region: PRK04366 1121448006287 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1121448006288 catalytic residue [active] 1121448006289 glycine dehydrogenase subunit 1; Validated; Region: PRK00451 1121448006290 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 1121448006291 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1121448006292 catalytic residue [active] 1121448006293 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1121448006294 lipoyl attachment site [posttranslational modification]; other site 1121448006295 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121448006296 Response regulator receiver domain; Region: Response_reg; pfam00072 1121448006297 active site 1121448006298 phosphorylation site [posttranslational modification] 1121448006299 intermolecular recognition site; other site 1121448006300 dimerization interface [polypeptide binding]; other site 1121448006301 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1121448006302 Zn2+ binding site [ion binding]; other site 1121448006303 Mg2+ binding site [ion binding]; other site 1121448006304 aspartate aminotransferase; Provisional; Region: PRK05764 1121448006305 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1121448006306 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1121448006307 homodimer interface [polypeptide binding]; other site 1121448006308 catalytic residue [active] 1121448006309 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1121448006310 S-adenosylmethionine binding site [chemical binding]; other site 1121448006311 AMIN domain; Region: AMIN; pfam11741 1121448006312 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1121448006313 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1121448006314 putative DNA binding site [nucleotide binding]; other site 1121448006315 putative Zn2+ binding site [ion binding]; other site 1121448006316 AsnC family; Region: AsnC_trans_reg; pfam01037 1121448006317 Proline dehydrogenase; Region: Pro_dh; cl03282 1121448006318 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 1121448006319 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 1121448006320 Glutamate binding site [chemical binding]; other site 1121448006321 homodimer interface [polypeptide binding]; other site 1121448006322 NAD binding site [chemical binding]; other site 1121448006323 catalytic residues [active] 1121448006324 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1121448006325 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1121448006326 motif 1; other site 1121448006327 active site 1121448006328 motif 2; other site 1121448006329 motif 3; other site 1121448006330 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1121448006331 DHHA1 domain; Region: DHHA1; pfam02272 1121448006332 recombinase A; Provisional; Region: recA; PRK09354 1121448006333 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1121448006334 hexamer interface [polypeptide binding]; other site 1121448006335 Walker A motif; other site 1121448006336 ATP binding site [chemical binding]; other site 1121448006337 Walker B motif; other site 1121448006338 B12 binding domain; Region: B12-binding; pfam02310 1121448006339 B12 binding site [chemical binding]; other site 1121448006340 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 1121448006341 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1121448006342 FeS/SAM binding site; other site 1121448006343 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1121448006344 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1121448006345 Coenzyme A binding pocket [chemical binding]; other site 1121448006346 integrase; Provisional; Region: int; PHA02601 1121448006347 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1121448006348 active site 1121448006349 catalytic residues [active] 1121448006350 DNA binding site [nucleotide binding] 1121448006351 Int/Topo IB signature motif; other site 1121448006352 AAA domain; Region: AAA_25; pfam13481 1121448006353 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1121448006354 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1121448006355 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1121448006356 Helix-turn-helix domain; Region: HTH_17; pfam12728 1121448006357 phenylalanyl-tRNA synthetase subunit alpha; Provisional; Region: pheS; PRK04172 1121448006358 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 1121448006359 active site 1121448006360 catalytic site [active] 1121448006361 substrate binding site [chemical binding]; other site 1121448006362 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 1121448006363 Predicted transcriptional regulator [Transcription]; Region: COG2932 1121448006364 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1121448006365 Catalytic site [active] 1121448006366 Y-family of DNA polymerases; Region: PolY; cl12025 1121448006367 DNA binding site [nucleotide binding] 1121448006368 CHC2 zinc finger; Region: zf-CHC2; cl17510 1121448006369 Transposase; Region: HTH_Tnp_1; cl17663 1121448006370 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 1121448006371 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 1121448006372 Toxin with endonuclease activity YhaV; Region: Toxin_YhaV; pfam11663 1121448006373 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 1121448006374 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1121448006375 cofactor binding site; other site 1121448006376 DNA binding site [nucleotide binding] 1121448006377 substrate interaction site [chemical binding]; other site 1121448006378 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c_3; pfam13589 1121448006379 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1121448006380 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121448006381 ATP binding site [chemical binding]; other site 1121448006382 Mg2+ binding site [ion binding]; other site 1121448006383 G-X-G motif; other site 1121448006384 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 1121448006385 Integrase core domain; Region: rve_3; pfam13683 1121448006386 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 1121448006387 additional DNA contacts [nucleotide binding]; other site 1121448006388 mismatch recognition site; other site 1121448006389 active site 1121448006390 zinc binding site [ion binding]; other site 1121448006391 DNA intercalation site [nucleotide binding]; other site 1121448006392 Domain of unknown function (DUF3883); Region: DUF3883; pfam13020 1121448006393 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 1121448006394 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1121448006395 cofactor binding site; other site 1121448006396 DNA binding site [nucleotide binding] 1121448006397 substrate interaction site [chemical binding]; other site 1121448006398 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 1121448006399 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1121448006400 Domain of unknown function (DUF1833); Region: DUF1833; pfam08875 1121448006401 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 1121448006402 tape measure domain; Region: tape_meas_nterm; TIGR02675 1121448006403 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1121448006404 NlpC/P60 family; Region: NLPC_P60; cl17555 1121448006405 Bacteriophage protein of unknown function (DUF646); Region: DUF646; cl12124 1121448006406 Phage related hypothetical protein (DUF1799); Region: DUF1799; pfam08809 1121448006407 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 1121448006408 phage conserved hypothetical protein, phiE125 gp8 family; Region: phage_chp_gp8; TIGR02215 1121448006409 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 1121448006410 Phage capsid family; Region: Phage_capsid; pfam05065 1121448006411 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 1121448006412 oligomer interface [polypeptide binding]; other site 1121448006413 Clp protease; Region: CLP_protease; pfam00574 1121448006414 active site residues [active] 1121448006415 Phage portal protein; Region: Phage_portal; pfam04860 1121448006416 Phage-related protein [Function unknown]; Region: COG4695 1121448006417 Phage Terminase; Region: Terminase_1; pfam03354 1121448006418 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 1121448006419 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1121448006420 active site 1121448006421 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1121448006422 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1121448006423 catalytic residue [active] 1121448006424 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1121448006425 HEPN domain; Region: HEPN; cl00824 1121448006426 Domain of unknown function (DUF955); Region: DUF955; pfam06114 1121448006427 Competence protein CoiA-like family; Region: CoiA; cl11541 1121448006428 ParB-like nuclease domain; Region: ParB; smart00470 1121448006429 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1121448006430 non-specific DNA binding site [nucleotide binding]; other site 1121448006431 salt bridge; other site 1121448006432 sequence-specific DNA binding site [nucleotide binding]; other site 1121448006433 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1121448006434 Flagellin and related hook-associated proteins [Cell motility and secretion]; Region: FlgL; COG1344 1121448006435 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1121448006436 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1121448006437 active site 1121448006438 DNA binding site [nucleotide binding] 1121448006439 Int/Topo IB signature motif; other site 1121448006440 Helix-turn-helix domain; Region: HTH_17; cl17695 1121448006441 integrase; Provisional; Region: int; PHA02601 1121448006442 Phage integrase family; Region: Phage_integrase; pfam00589 1121448006443 active site 1121448006444 DNA binding site [nucleotide binding] 1121448006445 Int/Topo IB signature motif; other site 1121448006446 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1121448006447 DsrE/DsrF-like family; Region: DrsE; pfam02635 1121448006448 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1121448006449 Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077 1121448006450 Response regulator receiver domain; Region: Response_reg; pfam00072 1121448006451 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121448006452 active site 1121448006453 phosphorylation site [posttranslational modification] 1121448006454 intermolecular recognition site; other site 1121448006455 dimerization interface [polypeptide binding]; other site 1121448006456 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1121448006457 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1121448006458 metal binding site [ion binding]; metal-binding site 1121448006459 active site 1121448006460 I-site; other site 1121448006461 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 1121448006462 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1121448006463 putative GEF interaction site [polypeptide binding]; other site 1121448006464 G1 box; other site 1121448006465 GTP/Mg2+ binding site [chemical binding]; other site 1121448006466 Switch I region; other site 1121448006467 G2 box; other site 1121448006468 G3 box; other site 1121448006469 Switch II region; other site 1121448006470 G4 box; other site 1121448006471 G5 box; other site 1121448006472 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1121448006473 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1121448006474 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1121448006475 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1121448006476 Walker A/P-loop; other site 1121448006477 ATP binding site [chemical binding]; other site 1121448006478 Q-loop/lid; other site 1121448006479 ABC transporter signature motif; other site 1121448006480 Walker B; other site 1121448006481 D-loop; other site 1121448006482 H-loop/switch region; other site 1121448006483 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1121448006484 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1121448006485 substrate binding pocket [chemical binding]; other site 1121448006486 membrane-bound complex binding site; other site 1121448006487 hinge residues; other site 1121448006488 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1121448006489 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121448006490 dimer interface [polypeptide binding]; other site 1121448006491 conserved gate region; other site 1121448006492 putative PBP binding loops; other site 1121448006493 ABC-ATPase subunit interface; other site 1121448006494 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1121448006495 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121448006496 dimer interface [polypeptide binding]; other site 1121448006497 conserved gate region; other site 1121448006498 putative PBP binding loops; other site 1121448006499 ABC-ATPase subunit interface; other site 1121448006500 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1121448006501 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 1121448006502 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 1121448006503 putative active site [active] 1121448006504 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1121448006505 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1121448006506 active site 1121448006507 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1121448006508 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 1121448006509 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1121448006510 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1121448006511 Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues; Region: GAG_Lyase; cl17706 1121448006512 substrate binding site [chemical binding]; other site 1121448006513 catalytic residues [active] 1121448006514 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1121448006515 putative active site [active] 1121448006516 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 1121448006517 feedback inhibition sensing region; other site 1121448006518 homohexameric interface [polypeptide binding]; other site 1121448006519 nucleotide binding site [chemical binding]; other site 1121448006520 N-acetyl-L-glutamate binding site [chemical binding]; other site 1121448006521 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 1121448006522 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1121448006523 Walker A motif; other site 1121448006524 ATP binding site [chemical binding]; other site 1121448006525 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 1121448006526 Walker B motif; other site 1121448006527 arginine finger; other site 1121448006528 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1121448006529 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 1121448006530 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1121448006531 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1121448006532 protein binding site [polypeptide binding]; other site 1121448006533 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1121448006534 protein binding site [polypeptide binding]; other site 1121448006535 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 1121448006536 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1121448006537 NlpC/P60 family; Region: NLPC_P60; pfam00877 1121448006538 PEGA domain; Region: PEGA; pfam08308 1121448006539 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1121448006540 TPR repeat; Region: TPR_11; pfam13414 1121448006541 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1121448006542 binding surface 1121448006543 TPR motif; other site 1121448006544 TPR repeat; Region: TPR_11; pfam13414 1121448006545 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1121448006546 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1121448006547 ligand binding site [chemical binding]; other site 1121448006548 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1121448006549 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1121448006550 ligand binding site [chemical binding]; other site 1121448006551 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1121448006552 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1121448006553 ligand binding site [chemical binding]; other site 1121448006554 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 1121448006555 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 1121448006556 trigger factor; Region: tig; TIGR00115 1121448006557 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1121448006558 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1121448006559 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 1121448006560 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1121448006561 oligomer interface [polypeptide binding]; other site 1121448006562 active site residues [active] 1121448006563 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1121448006564 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 1121448006565 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1121448006566 Walker A motif; other site 1121448006567 ATP binding site [chemical binding]; other site 1121448006568 Walker B motif; other site 1121448006569 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1121448006570 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 1121448006571 Found in ATP-dependent protease La (LON); Region: LON; smart00464 1121448006572 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1121448006573 Walker A motif; other site 1121448006574 ATP binding site [chemical binding]; other site 1121448006575 Walker B motif; other site 1121448006576 arginine finger; other site 1121448006577 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1121448006578 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1121448006579 S-adenosylmethionine binding site [chemical binding]; other site 1121448006580 DinB family; Region: DinB; cl17821 1121448006581 DinB superfamily; Region: DinB_2; pfam12867 1121448006582 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 1121448006583 Smr domain; Region: Smr; pfam01713 1121448006584 Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434 1121448006585 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290 1121448006586 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1121448006587 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1121448006588 putative substrate translocation pore; other site 1121448006589 YibE/F-like protein; Region: YibE_F; pfam07907 1121448006590 Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785 1121448006591 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 1121448006592 active site 1121448006593 dimer interface [polypeptide binding]; other site 1121448006594 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1121448006595 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1121448006596 4Fe-4S single cluster domain; Region: Fer4_13; pfam13370 1121448006597 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 1121448006598 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 1121448006599 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1121448006600 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1121448006601 dimer interface [polypeptide binding]; other site 1121448006602 phosphorylation site [posttranslational modification] 1121448006603 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121448006604 ATP binding site [chemical binding]; other site 1121448006605 Mg2+ binding site [ion binding]; other site 1121448006606 G-X-G motif; other site 1121448006607 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1121448006608 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1121448006609 dimer interface [polypeptide binding]; other site 1121448006610 phosphorylation site [posttranslational modification] 1121448006611 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121448006612 ATP binding site [chemical binding]; other site 1121448006613 Mg2+ binding site [ion binding]; other site 1121448006614 G-X-G motif; other site 1121448006615 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1121448006616 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1121448006617 Protein of unknown function DUF47; Region: PhoU_div; pfam01865 1121448006618 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 1121448006619 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 1121448006620 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1121448006621 TrkA-N domain; Region: TrkA_N; pfam02254 1121448006622 TrkA-C domain; Region: TrkA_C; pfam02080 1121448006623 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 1121448006624 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 1121448006625 putative homodimer interface [polypeptide binding]; other site 1121448006626 putative active site pocket [active] 1121448006627 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 1121448006628 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1121448006629 trimer interface [polypeptide binding]; other site 1121448006630 active site 1121448006631 acetylornithine aminotransferase; Provisional; Region: PRK02627 1121448006632 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1121448006633 inhibitor-cofactor binding pocket; inhibition site 1121448006634 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1121448006635 catalytic residue [active] 1121448006636 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1121448006637 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_10; cd07251 1121448006638 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1121448006639 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1121448006640 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1121448006641 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1121448006642 argininosuccinate lyase; Provisional; Region: PRK00855 1121448006643 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1121448006644 active sites [active] 1121448006645 tetramer interface [polypeptide binding]; other site 1121448006646 argininosuccinate synthase; Provisional; Region: PRK13820 1121448006647 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 1121448006648 ANP binding site [chemical binding]; other site 1121448006649 Substrate Binding Site II [chemical binding]; other site 1121448006650 Substrate Binding Site I [chemical binding]; other site 1121448006651 ornithine carbamoyltransferase; Provisional; Region: PRK00779 1121448006652 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1121448006653 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1121448006654 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1121448006655 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1121448006656 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1121448006657 dimer interface [polypeptide binding]; other site 1121448006658 phosphorylation site [posttranslational modification] 1121448006659 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121448006660 ATP binding site [chemical binding]; other site 1121448006661 Mg2+ binding site [ion binding]; other site 1121448006662 G-X-G motif; other site 1121448006663 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121448006664 Response regulator receiver domain; Region: Response_reg; pfam00072 1121448006665 active site 1121448006666 phosphorylation site [posttranslational modification] 1121448006667 intermolecular recognition site; other site 1121448006668 dimerization interface [polypeptide binding]; other site 1121448006669 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 1121448006670 GAF domain; Region: GAF_3; pfam13492 1121448006671 GAF domain; Region: GAF_2; pfam13185 1121448006672 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121448006673 Response regulator receiver domain; Region: Response_reg; pfam00072 1121448006674 active site 1121448006675 phosphorylation site [posttranslational modification] 1121448006676 intermolecular recognition site; other site 1121448006677 dimerization interface [polypeptide binding]; other site 1121448006678 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 1121448006679 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 1121448006680 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 1121448006681 Walker A motif; other site 1121448006682 ATP binding site [chemical binding]; other site 1121448006683 Walker B motif; other site 1121448006684 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 1121448006685 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 1121448006686 Tetramer interface [polypeptide binding]; other site 1121448006687 active site 1121448006688 FMN-binding site [chemical binding]; other site 1121448006689 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 1121448006690 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1121448006691 ADP binding site [chemical binding]; other site 1121448006692 magnesium binding site [ion binding]; other site 1121448006693 putative shikimate binding site; other site 1121448006694 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121448006695 putative active site [active] 1121448006696 PAS fold; Region: PAS_3; pfam08447 1121448006697 heme pocket [chemical binding]; other site 1121448006698 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1121448006699 dimer interface [polypeptide binding]; other site 1121448006700 phosphorylation site [posttranslational modification] 1121448006701 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121448006702 ATP binding site [chemical binding]; other site 1121448006703 Mg2+ binding site [ion binding]; other site 1121448006704 G-X-G motif; other site 1121448006705 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1121448006706 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1121448006707 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1121448006708 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1121448006709 Protein of unknown function (DUF554); Region: DUF554; pfam04474 1121448006710 mercuric reductase; Validated; Region: PRK06370 1121448006711 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1121448006712 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1121448006713 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1121448006714 Response regulator receiver domain; Region: Response_reg; pfam00072 1121448006715 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121448006716 active site 1121448006717 phosphorylation site [posttranslational modification] 1121448006718 intermolecular recognition site; other site 1121448006719 dimerization interface [polypeptide binding]; other site 1121448006720 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1121448006721 dimer interface [polypeptide binding]; other site 1121448006722 phosphorylation site [posttranslational modification] 1121448006723 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121448006724 ATP binding site [chemical binding]; other site 1121448006725 Mg2+ binding site [ion binding]; other site 1121448006726 G-X-G motif; other site 1121448006727 DinB superfamily; Region: DinB_2; pfam12867 1121448006728 Cache domain; Region: Cache_1; pfam02743 1121448006729 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1121448006730 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1121448006731 metal binding site [ion binding]; metal-binding site 1121448006732 active site 1121448006733 I-site; other site 1121448006734 CoA binding domain; Region: CoA_binding_2; pfam13380 1121448006735 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 1121448006736 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1121448006737 HSP70 interaction site [polypeptide binding]; other site 1121448006738 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1121448006739 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121448006740 putative active site [active] 1121448006741 heme pocket [chemical binding]; other site 1121448006742 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121448006743 putative active site [active] 1121448006744 heme pocket [chemical binding]; other site 1121448006745 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1121448006746 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1121448006747 dimer interface [polypeptide binding]; other site 1121448006748 phosphorylation site [posttranslational modification] 1121448006749 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121448006750 ATP binding site [chemical binding]; other site 1121448006751 Mg2+ binding site [ion binding]; other site 1121448006752 G-X-G motif; other site 1121448006753 Restriction endonuclease [Defense mechanisms]; Region: Mrr; COG1715 1121448006754 Mrr N-terminal domain; Region: Mrr_N; pfam14338 1121448006755 Restriction endonuclease; Region: Mrr_cat; pfam04471 1121448006756 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1121448006757 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 1121448006758 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1121448006759 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 1121448006760 Predicted HD-superfamily hydrolase [General function prediction only]; Region: COG3481 1121448006761 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 1121448006762 generic binding surface I; other site 1121448006763 generic binding surface II; other site 1121448006764 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1121448006765 Zn2+ binding site [ion binding]; other site 1121448006766 Mg2+ binding site [ion binding]; other site 1121448006767 thymidylate kinase; Validated; Region: tmk; PRK00698 1121448006768 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1121448006769 TMP-binding site; other site 1121448006770 ATP-binding site [chemical binding]; other site 1121448006771 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1121448006772 HI0933-like protein; Region: HI0933_like; pfam03486 1121448006773 Peptidase C1A subfamily (MEROPS database nomenclature); composed of cysteine peptidases (CPs) similar to papain, including the mammalian CPs (cathepsins B, C, F, H, L, K, O, S, V, X and W). Papain is an endopeptidase with specific substrate preferences; Region: Peptidase_C1A; cd02248 1121448006774 active site 1121448006775 S2 subsite; other site 1121448006776 diphosphate--fructose-6-phosphate 1-phosphotransferase; Provisional; Region: PRK06830 1121448006777 pyrophosphate--fructose-6-phosphate 1-phosphotransferase; Validated; Region: PRK06555 1121448006778 active site 1121448006779 ADP/pyrophosphate binding site [chemical binding]; other site 1121448006780 dimerization interface [polypeptide binding]; other site 1121448006781 allosteric effector site; other site 1121448006782 fructose-1,6-bisphosphate binding site; other site 1121448006783 Sec-independent protein translocase protein (TatC); Region: TatC; pfam00902 1121448006784 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 1121448006785 GMP synthase; Reviewed; Region: guaA; PRK00074 1121448006786 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1121448006787 AMP/PPi binding site [chemical binding]; other site 1121448006788 candidate oxyanion hole; other site 1121448006789 catalytic triad [active] 1121448006790 potential glutamine specificity residues [chemical binding]; other site 1121448006791 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1121448006792 ATP Binding subdomain [chemical binding]; other site 1121448006793 Ligand Binding sites [chemical binding]; other site 1121448006794 Dimerization subdomain; other site 1121448006795 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 1121448006796 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1121448006797 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 1121448006798 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1121448006799 active site 1121448006800 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1121448006801 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1121448006802 Walker A/P-loop; other site 1121448006803 ATP binding site [chemical binding]; other site 1121448006804 Q-loop/lid; other site 1121448006805 ABC transporter signature motif; other site 1121448006806 Walker B; other site 1121448006807 D-loop; other site 1121448006808 H-loop/switch region; other site 1121448006809 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1121448006810 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1121448006811 Walker A/P-loop; other site 1121448006812 ATP binding site [chemical binding]; other site 1121448006813 Q-loop/lid; other site 1121448006814 ABC transporter signature motif; other site 1121448006815 Walker B; other site 1121448006816 D-loop; other site 1121448006817 H-loop/switch region; other site 1121448006818 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1121448006819 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1121448006820 TM-ABC transporter signature motif; other site 1121448006821 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1121448006822 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1121448006823 TM-ABC transporter signature motif; other site 1121448006824 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1121448006825 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1121448006826 TPR repeat; Region: TPR_11; pfam13414 1121448006827 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1121448006828 TPR motif; other site 1121448006829 binding surface 1121448006830 TPR repeat; Region: TPR_11; pfam13414 1121448006831 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 1121448006832 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13539 1121448006833 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1121448006834 Walker A/P-loop; other site 1121448006835 ATP binding site [chemical binding]; other site 1121448006836 Q-loop/lid; other site 1121448006837 ABC transporter signature motif; other site 1121448006838 Walker B; other site 1121448006839 D-loop; other site 1121448006840 H-loop/switch region; other site 1121448006841 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138 1121448006842 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1121448006843 CcmE; Region: CcmE; cl00994 1121448006844 Domain of unknown function DUF21; Region: DUF21; pfam01595 1121448006845 FOG: CBS domain [General function prediction only]; Region: COG0517 1121448006846 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1121448006847 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1121448006848 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1121448006849 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 1121448006850 MarC family integral membrane protein; Region: MarC; pfam01914 1121448006851 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 1121448006852 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1121448006853 dimerization interface [polypeptide binding]; other site 1121448006854 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1121448006855 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1121448006856 dimer interface [polypeptide binding]; other site 1121448006857 putative CheW interface [polypeptide binding]; other site 1121448006858 Hemerythrin; Region: Hemerythrin; cd12107 1121448006859 Fe binding site [ion binding]; other site 1121448006860 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1121448006861 anti sigma factor interaction site; other site 1121448006862 regulatory phosphorylation site [posttranslational modification]; other site 1121448006863 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1121448006864 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1121448006865 OPT oligopeptide transporter protein; Region: OPT; cl14607 1121448006866 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238 1121448006867 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1121448006868 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1121448006869 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1121448006870 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1121448006871 Walker A/P-loop; other site 1121448006872 ATP binding site [chemical binding]; other site 1121448006873 Q-loop/lid; other site 1121448006874 ABC transporter signature motif; other site 1121448006875 Walker B; other site 1121448006876 D-loop; other site 1121448006877 H-loop/switch region; other site 1121448006878 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1121448006879 FtsX-like permease family; Region: FtsX; pfam02687 1121448006880 Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u4; cd10928 1121448006881 NodB motif; other site 1121448006882 putative active site [active] 1121448006883 putative catalytic site [active] 1121448006884 putative Zn binding site [ion binding]; other site 1121448006885 Predicted glycosyl transferase [General function prediction only]; Region: COG4671 1121448006886 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1121448006887 catalytic core [active] 1121448006888 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1121448006889 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1121448006890 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 1121448006891 colanic acid biosynthesis glycosyltransferase WcaL; Region: wcaL; TIGR04005 1121448006892 putative ADP-binding pocket [chemical binding]; other site 1121448006893 Predicted glycosyl transferase [General function prediction only]; Region: COG4671 1121448006894 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1121448006895 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1121448006896 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1121448006897 S-adenosylmethionine binding site [chemical binding]; other site 1121448006898 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 1121448006899 trimer interface [polypeptide binding]; other site 1121448006900 active site 1121448006901 substrate binding site [chemical binding]; other site 1121448006902 CoA binding site [chemical binding]; other site 1121448006903 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 1121448006904 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 1121448006905 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1121448006906 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 1121448006907 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 1121448006908 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 1121448006909 FOG: CBS domain [General function prediction only]; Region: COG0517 1121448006910 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1121448006911 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1121448006912 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1121448006913 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1121448006914 Walker A/P-loop; other site 1121448006915 ATP binding site [chemical binding]; other site 1121448006916 Q-loop/lid; other site 1121448006917 ABC transporter signature motif; other site 1121448006918 Walker B; other site 1121448006919 D-loop; other site 1121448006920 H-loop/switch region; other site 1121448006921 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1121448006922 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1121448006923 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 1121448006924 acyl-activating enzyme (AAE) consensus motif; other site 1121448006925 putative AMP binding site [chemical binding]; other site 1121448006926 putative active site [active] 1121448006927 putative CoA binding site [chemical binding]; other site 1121448006928 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1121448006929 TM-ABC transporter signature motif; other site 1121448006930 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1121448006931 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1121448006932 TM-ABC transporter signature motif; other site 1121448006933 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1121448006934 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1121448006935 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1121448006936 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1121448006937 Walker A/P-loop; other site 1121448006938 ATP binding site [chemical binding]; other site 1121448006939 Q-loop/lid; other site 1121448006940 ABC transporter signature motif; other site 1121448006941 Walker B; other site 1121448006942 D-loop; other site 1121448006943 H-loop/switch region; other site 1121448006944 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1121448006945 TPR motif; other site 1121448006946 binding surface 1121448006947 TPR repeat; Region: TPR_11; pfam13414 1121448006948 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432 1121448006949 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 1121448006950 active site 1121448006951 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1121448006952 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1121448006953 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1121448006954 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 1121448006955 MgtE intracellular N domain; Region: MgtE_N; pfam03448 1121448006956 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1121448006957 Divalent cation transporter; Region: MgtE; cl00786 1121448006958 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 1121448006959 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 1121448006960 dimerization interface [polypeptide binding]; other site 1121448006961 active site 1121448006962 quinolinate synthetase; Provisional; Region: PRK09375 1121448006963 rod shape-determining protein MreB; Provisional; Region: PRK13930 1121448006964 MreB and similar proteins; Region: MreB_like; cd10225 1121448006965 nucleotide binding site [chemical binding]; other site 1121448006966 Mg binding site [ion binding]; other site 1121448006967 putative protofilament interaction site [polypeptide binding]; other site 1121448006968 RodZ interaction site [polypeptide binding]; other site 1121448006969 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1121448006970 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1121448006971 phosphate binding site [ion binding]; other site 1121448006972 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1121448006973 Histidine kinase; Region: HisKA_3; pfam07730 1121448006974 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121448006975 ATP binding site [chemical binding]; other site 1121448006976 Mg2+ binding site [ion binding]; other site 1121448006977 G-X-G motif; other site 1121448006978 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1121448006979 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121448006980 active site 1121448006981 phosphorylation site [posttranslational modification] 1121448006982 intermolecular recognition site; other site 1121448006983 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1121448006984 DNA binding residues [nucleotide binding] 1121448006985 dimerization interface [polypeptide binding]; other site 1121448006986 HupF/HypC family; Region: HupF_HypC; pfam01455 1121448006987 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 1121448006988 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 1121448006989 putative substrate-binding site; other site 1121448006990 nickel binding site [ion binding]; other site 1121448006991 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 1121448006992 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374 1121448006993 Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740 1121448006994 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 1121448006995 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1121448006996 dimer interface [polypeptide binding]; other site 1121448006997 putative CheW interface [polypeptide binding]; other site 1121448006998 Cache domain; Region: Cache_1; pfam02743 1121448006999 6-phosphofructo-2-kinase; Region: 6PF2K; pfam01591 1121448007000 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cd02019 1121448007001 active site 1121448007002 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1121448007003 catalytic core [active] 1121448007004 Disulphide bond corrector protein DsbC; Region: DsbC; cl15830 1121448007005 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1121448007006 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1121448007007 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1121448007008 PAS domain; Region: PAS_8; pfam13188 1121448007009 putative active site [active] 1121448007010 heme pocket [chemical binding]; other site 1121448007011 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1121448007012 dimer interface [polypeptide binding]; other site 1121448007013 phosphorylation site [posttranslational modification] 1121448007014 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121448007015 ATP binding site [chemical binding]; other site 1121448007016 Mg2+ binding site [ion binding]; other site 1121448007017 G-X-G motif; other site 1121448007018 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1121448007019 quinol dehydrogenase membrane component; Provisional; Region: napH; PRK09477 1121448007020 4Fe-4S binding domain; Region: Fer4_5; pfam12801 1121448007021 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 1121448007022 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1121448007023 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1121448007024 D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942 1121448007025 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1121448007026 active site 1121448007027 motif I; other site 1121448007028 motif II; other site 1121448007029 selenium metabolism protein YedF; Region: selenium_YedF; TIGR03527 1121448007030 SirA_like_N, a protein of unknown function with an N-terminal SirA-like domain. The SirA, YedF, YeeD protein family is present in bacteria as well as archaea. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response...; Region: SirA_like_N; cd03421 1121448007031 CPxP motif; other site 1121448007032 DsrE/DsrF-like family; Region: DrsE; pfam02635 1121448007033 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1121448007034 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1121448007035 Coenzyme A binding pocket [chemical binding]; other site 1121448007036 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1121448007037 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 1121448007038 active site 1121448007039 intersubunit interactions; other site 1121448007040 catalytic residue [active] 1121448007041 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 1121448007042 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cl00233 1121448007043 catalytic center binding site [active] 1121448007044 ATP binding site [chemical binding]; other site 1121448007045 LL-diaminopimelate aminotransferase; Provisional; Region: PRK09276 1121448007046 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1121448007047 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1121448007048 homodimer interface [polypeptide binding]; other site 1121448007049 catalytic residue [active] 1121448007050 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1121448007051 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 1121448007052 active site 1121448007053 DNA binding site [nucleotide binding] 1121448007054 Int/Topo IB signature motif; other site 1121448007055 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 1121448007056 DHHA1 domain; Region: DHHA1; pfam02272 1121448007057 FOG: CBS domain [General function prediction only]; Region: COG0517 1121448007058 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with an upstream DHH domain which performs a phosphoesterase function and a downstream polyA polymerase domain. CBS is a small domain originally...; Region: CBS_pair_DHH_polyA_Pol_assoc; cd04595 1121448007059 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1121448007060 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 1121448007061 active site 1121448007062 NTP binding site [chemical binding]; other site 1121448007063 metal binding triad [ion binding]; metal-binding site 1121448007064 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1121448007065 Tim44-like domain; Region: Tim44; pfam04280 1121448007066 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 1121448007067 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1121448007068 PAS domain; Region: PAS_9; pfam13426 1121448007069 putative active site [active] 1121448007070 heme pocket [chemical binding]; other site 1121448007071 PAS domain; Region: PAS_9; pfam13426 1121448007072 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1121448007073 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121448007074 ATP binding site [chemical binding]; other site 1121448007075 Mg2+ binding site [ion binding]; other site 1121448007076 G-X-G motif; other site 1121448007077 Domain of unknown function (DUF3369); Region: DUF3369; pfam11849 1121448007078 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1121448007079 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1121448007080 metal binding site [ion binding]; metal-binding site 1121448007081 active site 1121448007082 I-site; other site 1121448007083 EVE domain; Region: EVE; cl00728 1121448007084 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1121448007085 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 1121448007086 active site 1121448007087 HIGH motif; other site 1121448007088 dimer interface [polypeptide binding]; other site 1121448007089 KMSKS motif; other site 1121448007090 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1121448007091 RNA binding surface [nucleotide binding]; other site 1121448007092 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1121448007093 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 1121448007094 putative active site [active] 1121448007095 metal binding site [ion binding]; metal-binding site 1121448007096 homodimer binding site [polypeptide binding]; other site 1121448007097 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1121448007098 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1121448007099 dimer interface [polypeptide binding]; other site 1121448007100 putative functional site; other site 1121448007101 putative MPT binding site; other site 1121448007102 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1121448007103 putative molybdopterin-guanine dinucleotide biosynthesis protein MobB/FeS domain-containing protein protein; Provisional; Region: PRK14494 1121448007104 Putative Fe-S cluster; Region: FeS; cl17515 1121448007105 NLPC_P60 stabilising domain, N term; Region: N_NLPC_P60; pfam12912 1121448007106 SH3 domain of the SH3b1 type; Region: SH3_6; pfam12913 1121448007107 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1121448007108 NlpC/P60 family; Region: NLPC_P60; cl17555 1121448007109 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1121448007110 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1121448007111 dimer interface [polypeptide binding]; other site 1121448007112 phosphorylation site [posttranslational modification] 1121448007113 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121448007114 ATP binding site [chemical binding]; other site 1121448007115 Mg2+ binding site [ion binding]; other site 1121448007116 G-X-G motif; other site 1121448007117 Response regulator receiver domain; Region: Response_reg; pfam00072 1121448007118 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121448007119 active site 1121448007120 phosphorylation site [posttranslational modification] 1121448007121 intermolecular recognition site; other site 1121448007122 dimerization interface [polypeptide binding]; other site 1121448007123 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 1121448007124 AAA domain; Region: AAA_30; pfam13604 1121448007125 Family description; Region: UvrD_C_2; pfam13538 1121448007126 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 1121448007127 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 1121448007128 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1121448007129 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 1121448007130 recombination factor protein RarA; Reviewed; Region: PRK13342 1121448007131 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1121448007132 Walker A motif; other site 1121448007133 ATP binding site [chemical binding]; other site 1121448007134 Walker B motif; other site 1121448007135 arginine finger; other site 1121448007136 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1121448007137 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 1121448007138 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1121448007139 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1121448007140 protein binding site [polypeptide binding]; other site 1121448007141 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1121448007142 protein binding site [polypeptide binding]; other site 1121448007143 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 1121448007144 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1121448007145 dimerization interface [polypeptide binding]; other site 1121448007146 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1121448007147 dimer interface [polypeptide binding]; other site 1121448007148 phosphorylation site [posttranslational modification] 1121448007149 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121448007150 ATP binding site [chemical binding]; other site 1121448007151 Mg2+ binding site [ion binding]; other site 1121448007152 G-X-G motif; other site 1121448007153 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1121448007154 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121448007155 active site 1121448007156 phosphorylation site [posttranslational modification] 1121448007157 intermolecular recognition site; other site 1121448007158 dimerization interface [polypeptide binding]; other site 1121448007159 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1121448007160 DNA binding site [nucleotide binding] 1121448007161 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 1121448007162 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1121448007163 NAD binding site [chemical binding]; other site 1121448007164 putative substrate binding site 2 [chemical binding]; other site 1121448007165 putative substrate binding site 1 [chemical binding]; other site 1121448007166 active site 1121448007167 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1121448007168 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1121448007169 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1121448007170 TrkA-N domain; Region: TrkA_N; pfam02254 1121448007171 TrkA-C domain; Region: TrkA_C; pfam02080 1121448007172 glycogen branching enzyme; Provisional; Region: PRK12313 1121448007173 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 1121448007174 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 1121448007175 active site 1121448007176 catalytic site [active] 1121448007177 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 1121448007178 glycogen synthase; Provisional; Region: glgA; PRK00654 1121448007179 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 1121448007180 ADP-binding pocket [chemical binding]; other site 1121448007181 homodimer interface [polypeptide binding]; other site 1121448007182 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 1121448007183 nudix motif; other site 1121448007184 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1121448007185 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1121448007186 putative active site [active] 1121448007187 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 1121448007188 MgtC family; Region: MgtC; pfam02308 1121448007189 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 1121448007190 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 1121448007191 Oligosaccharyl transferase STT3 subunit; Region: STT3; pfam02516 1121448007192 Ferric reductase like transmembrane component; Region: Ferric_reduct; pfam01794 1121448007193 NAD(P) binding domain of ferredoxin reductase-like proteins catalyze electron transfer between an NAD(P)-binding sub-domain of the alpha/beta class and a discrete (usually N-terminal) domain, which varies in orientation with respect to the NAD(P)...; Region: FNR_like_3; cd06198 1121448007194 FAD binding pocket [chemical binding]; other site 1121448007195 FAD binding motif [chemical binding]; other site 1121448007196 phosphate binding motif [ion binding]; other site 1121448007197 beta-alpha-beta structure motif; other site 1121448007198 NAD binding pocket [chemical binding]; other site 1121448007199 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; cl17726 1121448007200 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1121448007201 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1121448007202 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 1121448007203 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 1121448007204 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1121448007205 active site 1121448007206 HIGH motif; other site 1121448007207 KMSK motif region; other site 1121448007208 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1121448007209 tRNA binding surface [nucleotide binding]; other site 1121448007210 anticodon binding site; other site 1121448007211 pyruvoyl-dependent arginine decarboxylase; Reviewed; Region: PRK01285 1121448007212 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1121448007213 Permease; Region: Permease; pfam02405 1121448007214 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 1121448007215 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 1121448007216 Walker A/P-loop; other site 1121448007217 ATP binding site [chemical binding]; other site 1121448007218 Q-loop/lid; other site 1121448007219 ABC transporter signature motif; other site 1121448007220 Walker B; other site 1121448007221 D-loop; other site 1121448007222 H-loop/switch region; other site 1121448007223 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 1121448007224 mce related protein; Region: MCE; pfam02470 1121448007225 VacJ like lipoprotein; Region: VacJ; cl01073 1121448007226 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1121448007227 Radical SAM superfamily; Region: Radical_SAM; pfam04055 1121448007228 FeS/SAM binding site; other site 1121448007229 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1121448007230 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1121448007231 TPR motif; other site 1121448007232 PilZ domain; Region: PilZ; pfam07238 1121448007233 Response regulator receiver domain; Region: Response_reg; pfam00072 1121448007234 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121448007235 active site 1121448007236 phosphorylation site [posttranslational modification] 1121448007237 intermolecular recognition site; other site 1121448007238 dimerization interface [polypeptide binding]; other site 1121448007239 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121448007240 PAS domain; Region: PAS_9; pfam13426 1121448007241 putative active site [active] 1121448007242 heme pocket [chemical binding]; other site 1121448007243 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1121448007244 Histidine kinase; Region: HisKA_2; pfam07568 1121448007245 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121448007246 ATP binding site [chemical binding]; other site 1121448007247 Mg2+ binding site [ion binding]; other site 1121448007248 G-X-G motif; other site 1121448007249 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 1121448007250 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371 1121448007251 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 1121448007252 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1121448007253 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DedD; COG3147 1121448007254 Sporulation related domain; Region: SPOR; pfam05036 1121448007255 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1121448007256 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 1121448007257 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1121448007258 active site 1121448007259 dimer interface [polypeptide binding]; other site 1121448007260 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1121448007261 dimer interface [polypeptide binding]; other site 1121448007262 active site 1121448007263 DsrE/DsrF-like family; Region: DrsE; cl00672 1121448007264 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1121448007265 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1121448007266 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1121448007267 catalytic residue [active] 1121448007268 Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; cl01974 1121448007269 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1121448007270 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1121448007271 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1121448007272 catalytic residue [active] 1121448007273 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1121448007274 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 1121448007275 active site 1121448007276 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1121448007277 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 1121448007278 Probable Catalytic site; other site 1121448007279 metal-binding site 1121448007280 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 1121448007281 active site 1121448007282 SAM binding site [chemical binding]; other site 1121448007283 homodimer interface [polypeptide binding]; other site 1121448007284 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1121448007285 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1121448007286 intersubunit interface [polypeptide binding]; other site 1121448007287 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1121448007288 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1121448007289 Walker A/P-loop; other site 1121448007290 ATP binding site [chemical binding]; other site 1121448007291 Q-loop/lid; other site 1121448007292 ABC transporter signature motif; other site 1121448007293 Walker B; other site 1121448007294 D-loop; other site 1121448007295 H-loop/switch region; other site 1121448007296 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1121448007297 dimer interface [polypeptide binding]; other site 1121448007298 putative PBP binding regions; other site 1121448007299 ABC-ATPase subunit interface; other site 1121448007300 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 1121448007301 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1121448007302 active site 1121448007303 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 1121448007304 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 1121448007305 Predicted chitinase [General function prediction only]; Region: COG3179 1121448007306 catalytic residue [active] 1121448007307 tape measure domain; Region: tape_meas_nterm; TIGR02675 1121448007308 Domain of unknown function (DUF1834); Region: DUF1834; cl02087 1121448007309 Phage virion morphogenesis family; Region: Phage_tail_S; cl02089 1121448007310 cell surface protein SprA; Region: surface_SprA; TIGR04189 1121448007311 Protein of unknown function (DUF1320); Region: DUF1320; cl01818 1121448007312 Mu-like prophage major head subunit gpT; Region: Mu-like_gpT; cl01826 1121448007313 Mu-like prophage I protein; Region: Mu-like_Pro; pfam10123 1121448007314 Mu-like prophage I protein; Region: Mu-like_Pro; pfam10123 1121448007315 Holin family; Region: Phage_holin_4; pfam05105 1121448007316 Phage-related terminase [General function prediction only]; Region: COG5362; cl02216 1121448007317 Protein of unknown function (DUF935); Region: DUF935; pfam06074 1121448007318 Mu-like prophage protein gp29 [Function unknown]; Region: COG4383 1121448007319 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 1121448007320 Src Homology 3 domain superfamily; Region: SH3; cl17036 1121448007321 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1121448007322 non-specific DNA binding site [nucleotide binding]; other site 1121448007323 salt bridge; other site 1121448007324 sequence-specific DNA binding site [nucleotide binding]; other site 1121448007325 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1121448007326 Catalytic site [active] 1121448007327 BRO family, N-terminal domain; Region: Bro-N; smart01040 1121448007328 Integrase core domain; Region: rve; pfam00665 1121448007329 Integrase core domain; Region: rve_3; cl15866 1121448007330 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 1121448007331 AAA domain; Region: AAA_22; pfam13401 1121448007332 Protein of unknown function (DUF3164); Region: DUF3164; pfam11363 1121448007333 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1121448007334 IHF dimer interface [polypeptide binding]; other site 1121448007335 IHF - DNA interface [nucleotide binding]; other site 1121448007336 Protein of unknown function (DUF1018); Region: DUF1018; cl01815 1121448007337 Mor transcription activator family; Region: Mor; cl02360 1121448007338 MTH538 TIR-like domain (DUF1863); Region: DUF1863; pfam08937 1121448007339 TIR domain; Region: TIR_2; pfam13676 1121448007340 EamA-like transporter family; Region: EamA; pfam00892 1121448007341 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1121448007342 EamA-like transporter family; Region: EamA; pfam00892 1121448007343 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 1121448007344 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1121448007345 DHHA2 domain; Region: DHHA2; pfam02833 1121448007346 PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830 1121448007347 active site 1121448007348 phosphorylation site [posttranslational modification] 1121448007349 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1121448007350 active pocket/dimerization site; other site 1121448007351 active site 1121448007352 phosphorylation site [posttranslational modification] 1121448007353 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 1121448007354 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1121448007355 active site 1121448007356 phosphorylation site [posttranslational modification] 1121448007357 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1121448007358 30S subunit binding site; other site 1121448007359 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 1121448007360 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 1121448007361 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 1121448007362 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 1121448007363 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1121448007364 CTP synthetase; Validated; Region: pyrG; PRK05380 1121448007365 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1121448007366 Catalytic site [active] 1121448007367 active site 1121448007368 UTP binding site [chemical binding]; other site 1121448007369 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1121448007370 active site 1121448007371 putative oxyanion hole; other site 1121448007372 catalytic triad [active] 1121448007373 CobB/CobQ-like glutamine amidotransferase domain; Region: GATase_5; pfam13507 1121448007374 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1121448007375 conserved cys residue [active] 1121448007376 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1121448007377 nucleoside/Zn binding site; other site 1121448007378 dimer interface [polypeptide binding]; other site 1121448007379 catalytic motif [active] 1121448007380 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 1121448007381 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1121448007382 active site 1121448007383 Int/Topo IB signature motif; other site 1121448007384 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1121448007385 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1121448007386 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1121448007387 DNA-binding site [nucleotide binding]; DNA binding site 1121448007388 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1121448007389 hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234 1121448007390 tartronate semialdehyde reductase; Provisional; Region: garR; PRK11559 1121448007391 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1121448007392 Domain of unknown function (DUF4147); Region: DUF4147; pfam13660 1121448007393 Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379 1121448007394 MOFRL family; Region: MOFRL; pfam05161 1121448007395 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121448007396 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1121448007397 putative active site [active] 1121448007398 heme pocket [chemical binding]; other site 1121448007399 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121448007400 putative active site [active] 1121448007401 heme pocket [chemical binding]; other site 1121448007402 PAS domain; Region: PAS; smart00091 1121448007403 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1121448007404 putative active site [active] 1121448007405 heme pocket [chemical binding]; other site 1121448007406 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1121448007407 dimer interface [polypeptide binding]; other site 1121448007408 phosphorylation site [posttranslational modification] 1121448007409 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121448007410 ATP binding site [chemical binding]; other site 1121448007411 Mg2+ binding site [ion binding]; other site 1121448007412 G-X-G motif; other site 1121448007413 Response regulator receiver domain; Region: Response_reg; pfam00072 1121448007414 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121448007415 active site 1121448007416 phosphorylation site [posttranslational modification] 1121448007417 intermolecular recognition site; other site 1121448007418 dimerization interface [polypeptide binding]; other site 1121448007419 KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978 1121448007420 tetramer interface [polypeptide binding]; other site 1121448007421 dimer interface [polypeptide binding]; other site 1121448007422 KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978 1121448007423 tetramer interface [polypeptide binding]; other site 1121448007424 dimer interface [polypeptide binding]; other site 1121448007425 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1121448007426 circadian clock protein KaiC; Reviewed; Region: PRK09302 1121448007427 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1121448007428 Walker A motif; other site 1121448007429 Walker A motif; other site 1121448007430 ATP binding site [chemical binding]; other site 1121448007431 Walker B motif; other site 1121448007432 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1121448007433 ATP binding site [chemical binding]; other site 1121448007434 Walker B motif; other site 1121448007435 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1121448007436 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121448007437 putative active site [active] 1121448007438 heme pocket [chemical binding]; other site 1121448007439 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1121448007440 dimer interface [polypeptide binding]; other site 1121448007441 phosphorylation site [posttranslational modification] 1121448007442 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121448007443 ATP binding site [chemical binding]; other site 1121448007444 Mg2+ binding site [ion binding]; other site 1121448007445 G-X-G motif; other site 1121448007446 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1121448007447 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121448007448 active site 1121448007449 phosphorylation site [posttranslational modification] 1121448007450 intermolecular recognition site; other site 1121448007451 dimerization interface [polypeptide binding]; other site 1121448007452 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121448007453 putative active site [active] 1121448007454 heme pocket [chemical binding]; other site 1121448007455 Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201 1121448007456 CheB methylesterase; Region: CheB_methylest; pfam01339 1121448007457 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 1121448007458 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 1121448007459 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 1121448007460 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1; Region: Cenp-F_leu_zip; pfam10473 1121448007461 PAS domain; Region: PAS_10; pfam13596 1121448007462 PAS domain S-box; Region: sensory_box; TIGR00229 1121448007463 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121448007464 putative active site [active] 1121448007465 heme pocket [chemical binding]; other site 1121448007466 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121448007467 PAS fold; Region: PAS_3; pfam08447 1121448007468 putative active site [active] 1121448007469 heme pocket [chemical binding]; other site 1121448007470 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1121448007471 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1121448007472 Transposase domain (DUF772); Region: DUF772; pfam05598 1121448007473 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 1121448007474 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 1121448007475 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1121448007476 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1121448007477 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1121448007478 CRISPR/Cas system-associated protein Csb2; Region: Csb2_I-U; cl09827 1121448007479 CRISPR/Cas system-associated protein Csb1; Region: Csb1_I-U; cl09834 1121448007480 NACHT domain; Region: NACHT; pfam05729 1121448007481 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1121448007482 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1121448007483 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1121448007484 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1121448007485 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1121448007486 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1121448007487 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1121448007488 Domain of unknown function (DUF4016); Region: DUF4016; pfam13208 1121448007489 tellurite resistance protein terB; Region: terB; cd07176 1121448007490 putative metal binding site [ion binding]; other site 1121448007491 P-loop Domain of unknown function (DUF2791); Region: DUF2791; pfam10923 1121448007492 AAA ATPase domain; Region: AAA_16; pfam13191 1121448007493 Lhr-like helicases [General function prediction only]; Region: Lhr; COG1201 1121448007494 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1121448007495 putative Mg++ binding site [ion binding]; other site 1121448007496 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1121448007497 nucleotide binding region [chemical binding]; other site 1121448007498 Integrase core domain; Region: rve; pfam00665 1121448007499 Integrase core domain; Region: rve_3; pfam13683 1121448007500 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1121448007501 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1121448007502 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 1121448007503 dimerization interface [polypeptide binding]; other site 1121448007504 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 1121448007505 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1121448007506 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1121448007507 homodimer interface [polypeptide binding]; other site 1121448007508 catalytic residue [active] 1121448007509 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1121448007510 putative substrate translocation pore; other site 1121448007511 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1121448007512 xanthine dehydrogenase C subunit; Region: pucC; TIGR03199 1121448007513 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 1121448007514 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 1121448007515 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1121448007516 catalytic loop [active] 1121448007517 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 1121448007518 iron binding site [ion binding]; other site 1121448007519 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1121448007520 xanthine dehydrogenase D subunit; Region: pucD; TIGR03196 1121448007521 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 1121448007522 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1121448007523 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1121448007524 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1121448007525 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 1121448007526 active site 1121448007527 Response regulator receiver domain; Region: Response_reg; pfam00072 1121448007528 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121448007529 active site 1121448007530 phosphorylation site [posttranslational modification] 1121448007531 intermolecular recognition site; other site 1121448007532 dimerization interface [polypeptide binding]; other site 1121448007533 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1121448007534 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1121448007535 metal binding site [ion binding]; metal-binding site 1121448007536 active site 1121448007537 I-site; other site 1121448007538 PAS domain S-box; Region: sensory_box; TIGR00229 1121448007539 PAS domain S-box; Region: sensory_box; TIGR00229 1121448007540 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121448007541 putative active site [active] 1121448007542 heme pocket [chemical binding]; other site 1121448007543 PAS domain; Region: PAS_9; pfam13426 1121448007544 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121448007545 putative active site [active] 1121448007546 heme pocket [chemical binding]; other site 1121448007547 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1121448007548 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121448007549 putative active site [active] 1121448007550 heme pocket [chemical binding]; other site 1121448007551 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1121448007552 dimer interface [polypeptide binding]; other site 1121448007553 phosphorylation site [posttranslational modification] 1121448007554 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121448007555 ATP binding site [chemical binding]; other site 1121448007556 Mg2+ binding site [ion binding]; other site 1121448007557 G-X-G motif; other site 1121448007558 Response regulator receiver domain; Region: Response_reg; pfam00072 1121448007559 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121448007560 active site 1121448007561 phosphorylation site [posttranslational modification] 1121448007562 intermolecular recognition site; other site 1121448007563 dimerization interface [polypeptide binding]; other site 1121448007564 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 1121448007565 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1121448007566 putative substrate translocation pore; other site 1121448007567 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1121448007568 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 1121448007569 acyl-activating enzyme (AAE) consensus motif; other site 1121448007570 putative AMP binding site [chemical binding]; other site 1121448007571 putative active site [active] 1121448007572 putative CoA binding site [chemical binding]; other site 1121448007573 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 1121448007574 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1121448007575 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1121448007576 putative acyl-acceptor binding pocket; other site 1121448007577 Response regulator receiver domain; Region: Response_reg; pfam00072 1121448007578 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121448007579 active site 1121448007580 phosphorylation site [posttranslational modification] 1121448007581 intermolecular recognition site; other site 1121448007582 dimerization interface [polypeptide binding]; other site 1121448007583 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1121448007584 oxyanion hole [active] 1121448007585 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1121448007586 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 1121448007587 Walker A/P-loop; other site 1121448007588 ATP binding site [chemical binding]; other site 1121448007589 Q-loop/lid; other site 1121448007590 ABC transporter signature motif; other site 1121448007591 Walker B; other site 1121448007592 D-loop; other site 1121448007593 H-loop/switch region; other site 1121448007594 TOBE domain; Region: TOBE_2; pfam08402 1121448007595 hypothetical protein; Provisional; Region: PRK11622 1121448007596 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4134 1121448007597 2-aminoethylphosphonate transport system permease PhnU; Provisional; Region: PRK15050 1121448007598 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121448007599 dimer interface [polypeptide binding]; other site 1121448007600 conserved gate region; other site 1121448007601 putative PBP binding loops; other site 1121448007602 ABC-ATPase subunit interface; other site 1121448007603 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121448007604 putative PBP binding loops; other site 1121448007605 ABC-ATPase subunit interface; other site 1121448007606 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 1121448007607 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1121448007608 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1121448007609 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1121448007610 motif II; other site 1121448007611 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 1121448007612 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 1121448007613 nudix motif; other site 1121448007614 Protein of unknown function (DUF523); Region: DUF523; pfam04463 1121448007615 Uncharacterized conserved protein [Function unknown]; Region: COG3272 1121448007616 Protein of unknown function (DUF1722); Region: DUF1722; pfam08349 1121448007617 Domain of unknown function (DUF4279); Region: DUF4279; pfam14106 1121448007618 PilZ domain; Region: PilZ; pfam07238 1121448007619 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1121448007620 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980 1121448007621 Protein export membrane protein; Region: SecD_SecF; cl14618 1121448007622 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1121448007623 HlyD family secretion protein; Region: HlyD_3; pfam13437 1121448007624 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1121448007625 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1121448007626 Domain of unknown function (DUF1956); Region: DUF1956; pfam09209 1121448007627 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1121448007628 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1121448007629 substrate binding pocket [chemical binding]; other site 1121448007630 membrane-bound complex binding site; other site 1121448007631 hinge residues; other site 1121448007632 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 1121448007633 active site 1121448007634 catalytic motif [active] 1121448007635 Zn binding site [ion binding]; other site 1121448007636 PilZ domain; Region: PilZ; pfam07238 1121448007637 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 1121448007638 active site 1121448007639 hydrophilic channel; other site 1121448007640 dimerization interface [polypeptide binding]; other site 1121448007641 catalytic residues [active] 1121448007642 active site lid [active] 1121448007643 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 1121448007644 putative carbohydrate kinase; Provisional; Region: PRK10565 1121448007645 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 1121448007646 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1121448007647 putative substrate binding site [chemical binding]; other site 1121448007648 putative ATP binding site [chemical binding]; other site 1121448007649 FOG: CBS domain [General function prediction only]; Region: COG0517 1121448007650 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1121448007651 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 1121448007652 aspartate kinase; Reviewed; Region: PRK06635 1121448007653 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 1121448007654 putative nucleotide binding site [chemical binding]; other site 1121448007655 putative catalytic residues [active] 1121448007656 putative Mg ion binding site [ion binding]; other site 1121448007657 putative aspartate binding site [chemical binding]; other site 1121448007658 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 1121448007659 putative allosteric regulatory site; other site 1121448007660 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 1121448007661 putative allosteric regulatory residue; other site 1121448007662 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 1121448007663 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 1121448007664 active site 1121448007665 catalytic residues [active] 1121448007666 metal binding site [ion binding]; metal-binding site 1121448007667 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 1121448007668 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1121448007669 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1121448007670 dimer interface [polypeptide binding]; other site 1121448007671 phosphorylation site [posttranslational modification] 1121448007672 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121448007673 ATP binding site [chemical binding]; other site 1121448007674 Mg2+ binding site [ion binding]; other site 1121448007675 G-X-G motif; other site 1121448007676 Response regulator receiver domain; Region: Response_reg; pfam00072 1121448007677 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121448007678 active site 1121448007679 phosphorylation site [posttranslational modification] 1121448007680 intermolecular recognition site; other site 1121448007681 dimerization interface [polypeptide binding]; other site 1121448007682 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1121448007683 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1121448007684 metal binding site [ion binding]; metal-binding site 1121448007685 active site 1121448007686 I-site; other site 1121448007687 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 1121448007688 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 1121448007689 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1121448007690 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1121448007691 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1121448007692 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1121448007693 DNA binding residues [nucleotide binding] 1121448007694 DNA primase; Validated; Region: dnaG; PRK05667 1121448007695 CHC2 zinc finger; Region: zf-CHC2; pfam01807 1121448007696 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1121448007697 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1121448007698 active site 1121448007699 metal binding site [ion binding]; metal-binding site 1121448007700 interdomain interaction site; other site 1121448007701 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 1121448007702 MutS domain III; Region: MutS_III; pfam05192 1121448007703 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1121448007704 Walker A/P-loop; other site 1121448007705 ATP binding site [chemical binding]; other site 1121448007706 Q-loop/lid; other site 1121448007707 ABC transporter signature motif; other site 1121448007708 Walker B; other site 1121448007709 D-loop; other site 1121448007710 H-loop/switch region; other site 1121448007711 Smr domain; Region: Smr; pfam01713 1121448007712 Yqey-like protein; Region: YqeY; pfam09424 1121448007713 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 1121448007714 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1121448007715 IHF dimer interface [polypeptide binding]; other site 1121448007716 IHF - DNA interface [nucleotide binding]; other site 1121448007717 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1121448007718 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1121448007719 S-adenosylmethionine binding site [chemical binding]; other site 1121448007720 Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; pfam09835 1121448007721 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1121448007722 elongation factor G; Reviewed; Region: PRK12740 1121448007723 G1 box; other site 1121448007724 putative GEF interaction site [polypeptide binding]; other site 1121448007725 GTP/Mg2+ binding site [chemical binding]; other site 1121448007726 Switch I region; other site 1121448007727 G2 box; other site 1121448007728 G3 box; other site 1121448007729 Switch II region; other site 1121448007730 G4 box; other site 1121448007731 G5 box; other site 1121448007732 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1121448007733 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cd01680 1121448007734 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1121448007735 Outer membrane lipoprotein; Region: YfiO; pfam13525 1121448007736 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1121448007737 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1121448007738 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1121448007739 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1121448007740 catalytic residues [active] 1121448007741 UGMP family protein; Validated; Region: PRK09604 1121448007742 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 1121448007743 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 1121448007744 AMP binding site [chemical binding]; other site 1121448007745 metal binding site [ion binding]; metal-binding site 1121448007746 active site 1121448007747 hypothetical protein; Provisional; Region: PHA03169 1121448007748 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 1121448007749 Septum formation initiator; Region: DivIC; pfam04977 1121448007750 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 1121448007751 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 1121448007752 Walker A motif; other site 1121448007753 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1121448007754 Predicted membrane protein [Function unknown]; Region: COG1238 1121448007755 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 1121448007756 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1121448007757 FOG: CBS domain [General function prediction only]; Region: COG0517 1121448007758 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1121448007759 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1121448007760 Peptidase family M23; Region: Peptidase_M23; pfam01551 1121448007761 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1121448007762 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1121448007763 catalytic residues [active] 1121448007764 Putative phosphatase (DUF442); Region: DUF442; cl17385 1121448007765 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 1121448007766 tetramerization interface [polypeptide binding]; other site 1121448007767 active site 1121448007768 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1121448007769 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1121448007770 Walker A/P-loop; other site 1121448007771 ATP binding site [chemical binding]; other site 1121448007772 Q-loop/lid; other site 1121448007773 ABC transporter signature motif; other site 1121448007774 Walker B; other site 1121448007775 D-loop; other site 1121448007776 H-loop/switch region; other site 1121448007777 Apocytochrome F, C-terminal; Region: Apocytochr_F_C; cl03168 1121448007778 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1121448007779 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121448007780 dimer interface [polypeptide binding]; other site 1121448007781 conserved gate region; other site 1121448007782 putative PBP binding loops; other site 1121448007783 ABC-ATPase subunit interface; other site 1121448007784 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1121448007785 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1121448007786 substrate binding pocket [chemical binding]; other site 1121448007787 membrane-bound complex binding site; other site 1121448007788 hinge residues; other site 1121448007789 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1121448007790 GAF domain; Region: GAF; pfam01590 1121448007791 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1121448007792 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 1121448007793 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1121448007794 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 1121448007795 putative ADP-binding pocket [chemical binding]; other site 1121448007796 ribonuclease R; Region: RNase_R; TIGR02063 1121448007797 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 1121448007798 RNB domain; Region: RNB; pfam00773 1121448007799 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 1121448007800 RNA binding site [nucleotide binding]; other site 1121448007801 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 1121448007802 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 1121448007803 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1121448007804 metal binding triad; other site 1121448007805 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1121448007806 [Protein-PII] uridylyltransferase; Region: UTase_glnD; TIGR01693 1121448007807 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1121448007808 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1121448007809 Nitrogen regulatory protein P-II; Region: P-II; pfam00543 1121448007810 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1121448007811 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 1121448007812 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1121448007813 Peptidase family U32; Region: Peptidase_U32; pfam01136 1121448007814 Peptidase family U32; Region: Peptidase_U32; cl03113 1121448007815 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 1121448007816 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 1121448007817 FAD binding pocket [chemical binding]; other site 1121448007818 FAD binding motif [chemical binding]; other site 1121448007819 phosphate binding motif [ion binding]; other site 1121448007820 beta-alpha-beta structure motif; other site 1121448007821 NAD binding pocket [chemical binding]; other site 1121448007822 Iron coordination center [ion binding]; other site 1121448007823 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 1121448007824 heterodimer interface [polypeptide binding]; other site 1121448007825 active site 1121448007826 FMN binding site [chemical binding]; other site 1121448007827 homodimer interface [polypeptide binding]; other site 1121448007828 substrate binding site [chemical binding]; other site 1121448007829 Beta-lactamase class D [Defense mechanisms]; Region: COG2602 1121448007830 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 1121448007831 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1121448007832 acyl-activating enzyme (AAE) consensus motif; other site 1121448007833 active site 1121448007834 AMP binding site [chemical binding]; other site 1121448007835 CoA binding site [chemical binding]; other site 1121448007836 DUF based on E. rectale Gene description (DUF3880); Region: DUF3880; pfam12996 1121448007837 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 1121448007838 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1121448007839 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1121448007840 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 1121448007841 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 1121448007842 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 1121448007843 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 1121448007844 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 1121448007845 tRNA; other site 1121448007846 putative tRNA binding site [nucleotide binding]; other site 1121448007847 putative NADP binding site [chemical binding]; other site 1121448007848 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 1121448007849 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 1121448007850 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1121448007851 Ligand Binding Site [chemical binding]; other site 1121448007852 adenylate kinase; Provisional; Region: PRK14529 1121448007853 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1121448007854 AMP-binding site [chemical binding]; other site 1121448007855 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1121448007856 Cation transport protein; Region: TrkH; cl17365 1121448007857 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 1121448007858 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 1121448007859 TrkA-N domain; Region: TrkA_N; pfam02254 1121448007860 TrkA-C domain; Region: TrkA_C; pfam02080 1121448007861 TrkA-N domain; Region: TrkA_N; pfam02254 1121448007862 TrkA-C domain; Region: TrkA_C; pfam02080 1121448007863 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 1121448007864 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 1121448007865 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1121448007866 TPR motif; other site 1121448007867 binding surface 1121448007868 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cl00399 1121448007869 MoaE homodimer interface [polypeptide binding]; other site 1121448007870 MoaD interaction [polypeptide binding]; other site 1121448007871 active site residues [active] 1121448007872 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 1121448007873 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1121448007874 Walker A motif; other site 1121448007875 ATP binding site [chemical binding]; other site 1121448007876 Walker B motif; other site 1121448007877 arginine finger; other site 1121448007878 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1121448007879 Walker A motif; other site 1121448007880 ATP binding site [chemical binding]; other site 1121448007881 Walker B motif; other site 1121448007882 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1121448007883 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1121448007884 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 1121448007885 AAA domain; Region: AAA_21; pfam13304 1121448007886 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 1121448007887 Q-loop/lid; other site 1121448007888 ABC transporter signature motif; other site 1121448007889 Walker B; other site 1121448007890 D-loop; other site 1121448007891 H-loop/switch region; other site 1121448007892 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 1121448007893 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 1121448007894 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1121448007895 Walker A motif; other site 1121448007896 ATP binding site [chemical binding]; other site 1121448007897 Walker B motif; other site 1121448007898 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 1121448007899 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1121448007900 Walker A motif; other site 1121448007901 ATP binding site [chemical binding]; other site 1121448007902 Walker B motif; other site 1121448007903 Domain of unknown function DUF77; Region: DUF77; pfam01910 1121448007904 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 1121448007905 substrate binding site [chemical binding]; other site 1121448007906 multimerization interface [polypeptide binding]; other site 1121448007907 ATP binding site [chemical binding]; other site 1121448007908 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1121448007909 thiamine phosphate binding site [chemical binding]; other site 1121448007910 active site 1121448007911 pyrophosphate binding site [ion binding]; other site 1121448007912 Predicted transcriptional regulator [Transcription]; Region: COG2378 1121448007913 HTH domain; Region: HTH_11; pfam08279 1121448007914 WYL domain; Region: WYL; pfam13280 1121448007915 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1121448007916 Enoylreductase; Region: PKS_ER; smart00829 1121448007917 NAD(P) binding site [chemical binding]; other site 1121448007918 SnoaL-like domain; Region: SnoaL_2; pfam12680 1121448007919 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1121448007920 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 1121448007921 thiamine biosynthesis protein ThiF; Validated; Region: PRK05600 1121448007922 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1121448007923 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1121448007924 putative substrate translocation pore; other site 1121448007925 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1121448007926 Putative Fe-S cluster; Region: FeS; cl17515 1121448007927 Uncharacterized protein containing a ferredoxin domain (DUF2148); Region: DUF2148; pfam09918 1121448007928 Chromate resistance exported protein; Region: Chrome_Resist; cl01744 1121448007929 PAS fold; Region: PAS_2; pfam08446 1121448007930 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1121448007931 Phytochrome region; Region: PHY; pfam00360 1121448007932 PAS domain S-box; Region: sensory_box; TIGR00229 1121448007933 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121448007934 putative active site [active] 1121448007935 heme pocket [chemical binding]; other site 1121448007936 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1121448007937 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1121448007938 metal binding site [ion binding]; metal-binding site 1121448007939 active site 1121448007940 I-site; other site 1121448007941 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl17299 1121448007942 heme binding pocket [chemical binding]; other site 1121448007943 CheD chemotactic sensory transduction; Region: CheD; cl00810 1121448007944 Response regulator receiver domain; Region: Response_reg; pfam00072 1121448007945 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121448007946 active site 1121448007947 phosphorylation site [posttranslational modification] 1121448007948 intermolecular recognition site; other site 1121448007949 dimerization interface [polypeptide binding]; other site 1121448007950 PAS fold; Region: PAS_4; pfam08448 1121448007951 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1121448007952 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1121448007953 phosphorylation site [posttranslational modification] 1121448007954 dimer interface [polypeptide binding]; other site 1121448007955 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121448007956 ATP binding site [chemical binding]; other site 1121448007957 Mg2+ binding site [ion binding]; other site 1121448007958 G-X-G motif; other site 1121448007959 B12 binding domain; Region: B12-binding_2; pfam02607 1121448007960 Predicted cobalamin binding protein [General function prediction only]; Region: COG5012 1121448007961 B12 binding domain; Region: B12-binding; pfam02310 1121448007962 B12 binding site [chemical binding]; other site 1121448007963 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 1121448007964 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 1121448007965 ABC transporter substrate binding protein; Region: ABC_sub_bind; cl17301 1121448007966 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121448007967 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1121448007968 putative active site [active] 1121448007969 heme pocket [chemical binding]; other site 1121448007970 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121448007971 putative active site [active] 1121448007972 heme pocket [chemical binding]; other site 1121448007973 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1121448007974 GAF domain; Region: GAF; cl17456 1121448007975 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1121448007976 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1121448007977 dimer interface [polypeptide binding]; other site 1121448007978 phosphorylation site [posttranslational modification] 1121448007979 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121448007980 ATP binding site [chemical binding]; other site 1121448007981 Mg2+ binding site [ion binding]; other site 1121448007982 G-X-G motif; other site 1121448007983 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1121448007984 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121448007985 active site 1121448007986 phosphorylation site [posttranslational modification] 1121448007987 intermolecular recognition site; other site 1121448007988 dimerization interface [polypeptide binding]; other site 1121448007989 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 1121448007990 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1121448007991 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1121448007992 dimerization interface [polypeptide binding]; other site 1121448007993 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1121448007994 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1121448007995 dimer interface [polypeptide binding]; other site 1121448007996 putative CheW interface [polypeptide binding]; other site 1121448007997 FOG: CBS domain [General function prediction only]; Region: COG0517 1121448007998 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc2; cd04585 1121448007999 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1121448008000 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 1121448008001 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1121448008002 conserved cys residue [active] 1121448008003 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 1121448008004 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1121448008005 ligand binding site [chemical binding]; other site 1121448008006 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 1121448008007 CHASE4 domain; Region: CHASE4; pfam05228 1121448008008 HAMP domain; Region: HAMP; pfam00672 1121448008009 dimerization interface [polypeptide binding]; other site 1121448008010 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1121448008011 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121448008012 putative active site [active] 1121448008013 heme pocket [chemical binding]; other site 1121448008014 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1121448008015 dimer interface [polypeptide binding]; other site 1121448008016 phosphorylation site [posttranslational modification] 1121448008017 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121448008018 ATP binding site [chemical binding]; other site 1121448008019 Mg2+ binding site [ion binding]; other site 1121448008020 G-X-G motif; other site 1121448008021 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1121448008022 active site 1121448008023 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 1121448008024 alanine racemase; Reviewed; Region: alr; PRK00053 1121448008025 active site 1121448008026 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1121448008027 dimer interface [polypeptide binding]; other site 1121448008028 substrate binding site [chemical binding]; other site 1121448008029 catalytic residues [active] 1121448008030 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 1121448008031 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 1121448008032 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1121448008033 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1121448008034 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1121448008035 replicative DNA helicase; Region: DnaB; TIGR00665 1121448008036 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1121448008037 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1121448008038 Walker A motif; other site 1121448008039 ATP binding site [chemical binding]; other site 1121448008040 Walker B motif; other site 1121448008041 DNA binding loops [nucleotide binding] 1121448008042 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 1121448008043 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 1121448008044 Menaquinone biosynthesis; Region: VitK2_biosynth; cl17475 1121448008045 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1121448008046 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1121448008047 putative menaquinone biosynthesis protein, SCO4494 family; Region: mena_SCO4494; TIGR03700 1121448008048 menaquinone biosynthesis protein, SCO4550 family; Region: mena_SCO4550; TIGR03699 1121448008049 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1121448008050 FeS/SAM binding site; other site 1121448008051 Menaquinone biosynthesis; Region: VitK2_biosynth; pfam02621 1121448008052 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1121448008053 Amidohydrolase; Region: Amidohydro_4; pfam13147 1121448008054 active site 1121448008055 futalosine nucleosidase; Region: fut_nucase; TIGR03664 1121448008056 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1121448008057 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 1121448008058 putative heme d1 biosynthesis radical SAM protein NirJ2; Region: rSAM_NirJ2; TIGR04055 1121448008059 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1121448008060 FeS/SAM binding site; other site 1121448008061 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 1121448008062 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 1121448008063 dimer interface [polypeptide binding]; other site 1121448008064 active site 1121448008065 Schiff base residues; other site 1121448008066 putative heme d1 biosynthesis radical SAM protein NirJ1; Region: rSAM_NirJ1; TIGR04054 1121448008067 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1121448008068 FeS/SAM binding site; other site 1121448008069 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 1121448008070 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 1121448008071 Sodium Bile acid symporter family; Region: SBF; cl17470 1121448008072 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1121448008073 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1121448008074 ligand binding site [chemical binding]; other site 1121448008075 flexible hinge region; other site 1121448008076 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1121448008077 non-specific DNA interactions [nucleotide binding]; other site 1121448008078 DNA binding site [nucleotide binding] 1121448008079 sequence specific DNA binding site [nucleotide binding]; other site 1121448008080 putative cAMP binding site [chemical binding]; other site 1121448008081 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 1121448008082 Isochorismatase family; Region: Isochorismatase; pfam00857 1121448008083 catalytic triad [active] 1121448008084 conserved cis-peptide bond; other site 1121448008085 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 1121448008086 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 1121448008087 active site 1121448008088 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 1121448008089 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1121448008090 Peptidase family U32; Region: Peptidase_U32; pfam01136 1121448008091 4-alpha-glucanotransferase; Provisional; Region: PRK14508 1121448008092 CheD chemotactic sensory transduction; Region: CheD; cl00810 1121448008093 HDOD domain; Region: HDOD; pfam08668 1121448008094 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cl17503 1121448008095 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 1121448008096 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1121448008097 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1121448008098 Walker A/P-loop; other site 1121448008099 ATP binding site [chemical binding]; other site 1121448008100 Q-loop/lid; other site 1121448008101 ABC transporter signature motif; other site 1121448008102 Walker B; other site 1121448008103 D-loop; other site 1121448008104 H-loop/switch region; other site 1121448008105 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1121448008106 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1121448008107 Walker A/P-loop; other site 1121448008108 ATP binding site [chemical binding]; other site 1121448008109 Q-loop/lid; other site 1121448008110 ABC transporter signature motif; other site 1121448008111 Walker B; other site 1121448008112 D-loop; other site 1121448008113 H-loop/switch region; other site 1121448008114 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1121448008115 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1121448008116 TM-ABC transporter signature motif; other site 1121448008117 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1121448008118 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1121448008119 TM-ABC transporter signature motif; other site 1121448008120 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1121448008121 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 1121448008122 putative ligand binding site [chemical binding]; other site 1121448008123 peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903 1121448008124 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 1121448008125 substrate binding site [chemical binding]; other site 1121448008126 hypothetical protein; Provisional; Region: PRK04194 1121448008127 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 1121448008128 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1121448008129 dimerization interface [polypeptide binding]; other site 1121448008130 PAS domain; Region: PAS; smart00091 1121448008131 PAS domain; Region: PAS_9; pfam13426 1121448008132 PAS domain S-box; Region: sensory_box; TIGR00229 1121448008133 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121448008134 putative active site [active] 1121448008135 heme pocket [chemical binding]; other site 1121448008136 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1121448008137 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1121448008138 metal binding site [ion binding]; metal-binding site 1121448008139 active site 1121448008140 I-site; other site 1121448008141 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1121448008142 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1121448008143 Type I periplasmic binding domain of uncharacterized extracellular ligand-binding proteins; Region: PBP1_STKc_like; cd06326 1121448008144 putative ligand binding site [chemical binding]; other site 1121448008145 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1121448008146 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 1121448008147 homodimer interface [polypeptide binding]; other site 1121448008148 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 1121448008149 active site pocket [active] 1121448008150 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 1121448008151 Glucose inhibited division protein A; Region: GIDA; pfam01134 1121448008152 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1121448008153 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1121448008154 binding surface 1121448008155 TPR motif; other site 1121448008156 TPR repeat; Region: TPR_11; pfam13414 1121448008157 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 1121448008158 bacteriophage N4 adsorption protein B; Provisional; Region: nfrB; PRK11234 1121448008159 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365 1121448008160 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1121448008161 binding surface 1121448008162 TPR motif; other site 1121448008163 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1121448008164 PAS domain; Region: PAS_9; pfam13426 1121448008165 PAS domain S-box; Region: sensory_box; TIGR00229 1121448008166 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121448008167 putative active site [active] 1121448008168 heme pocket [chemical binding]; other site 1121448008169 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1121448008170 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121448008171 putative active site [active] 1121448008172 heme pocket [chemical binding]; other site 1121448008173 PAS domain; Region: PAS; smart00091 1121448008174 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1121448008175 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1121448008176 dimer interface [polypeptide binding]; other site 1121448008177 phosphorylation site [posttranslational modification] 1121448008178 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121448008179 ATP binding site [chemical binding]; other site 1121448008180 Mg2+ binding site [ion binding]; other site 1121448008181 G-X-G motif; other site 1121448008182 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1121448008183 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121448008184 active site 1121448008185 phosphorylation site [posttranslational modification] 1121448008186 intermolecular recognition site; other site 1121448008187 dimerization interface [polypeptide binding]; other site 1121448008188 Response regulator receiver domain; Region: Response_reg; pfam00072 1121448008189 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121448008190 active site 1121448008191 phosphorylation site [posttranslational modification] 1121448008192 intermolecular recognition site; other site 1121448008193 dimerization interface [polypeptide binding]; other site 1121448008194 Response regulator receiver domain; Region: Response_reg; pfam00072 1121448008195 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121448008196 active site 1121448008197 phosphorylation site [posttranslational modification] 1121448008198 intermolecular recognition site; other site 1121448008199 dimerization interface [polypeptide binding]; other site 1121448008200 Domain of unknown function (DUF3859); Region: DUF3859; pfam12975 1121448008201 Sporulation related domain; Region: SPOR; pfam05036 1121448008202 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 1121448008203 RNA polymerase sigma factor SigW; Provisional; Region: PRK09641 1121448008204 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1121448008205 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1121448008206 DNA binding residues [nucleotide binding] 1121448008207 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1121448008208 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 1121448008209 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1121448008210 dimerization interface [polypeptide binding]; other site 1121448008211 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1121448008212 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1121448008213 dimer interface [polypeptide binding]; other site 1121448008214 putative CheW interface [polypeptide binding]; other site 1121448008215 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1121448008216 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1121448008217 putative dimer interface [polypeptide binding]; other site 1121448008218 PAS domain S-box; Region: sensory_box; TIGR00229 1121448008219 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121448008220 putative active site [active] 1121448008221 heme pocket [chemical binding]; other site 1121448008222 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121448008223 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1121448008224 putative active site [active] 1121448008225 heme pocket [chemical binding]; other site 1121448008226 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121448008227 ATP binding site [chemical binding]; other site 1121448008228 Mg2+ binding site [ion binding]; other site 1121448008229 G-X-G motif; other site 1121448008230 Protein of unknown function DUF115; Region: MAF_flag10; pfam01973 1121448008231 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1121448008232 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1121448008233 dimer interface [polypeptide binding]; other site 1121448008234 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1121448008235 catalytic residue [active] 1121448008236 Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: CysS; COG0215 1121448008237 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1121448008238 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1121448008239 substrate binding pocket [chemical binding]; other site 1121448008240 membrane-bound complex binding site; other site 1121448008241 hinge residues; other site 1121448008242 Domain of unknown function (DUF389); Region: DUF389; cl00781 1121448008243 O-Antigen ligase; Region: Wzy_C; cl04850 1121448008244 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1121448008245 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1121448008246 Zn2+ binding site [ion binding]; other site 1121448008247 Mg2+ binding site [ion binding]; other site 1121448008248 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1121448008249 synthetase active site [active] 1121448008250 NTP binding site [chemical binding]; other site 1121448008251 metal binding site [ion binding]; metal-binding site 1121448008252 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1121448008253 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1121448008254 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 1121448008255 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 1121448008256 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1121448008257 ATP binding site [chemical binding]; other site 1121448008258 putative Mg++ binding site [ion binding]; other site 1121448008259 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1121448008260 nucleotide binding region [chemical binding]; other site 1121448008261 ATP-binding site [chemical binding]; other site 1121448008262 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1121448008263 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1121448008264 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1121448008265 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1121448008266 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1121448008267 Walker A/P-loop; other site 1121448008268 ATP binding site [chemical binding]; other site 1121448008269 Q-loop/lid; other site 1121448008270 ABC transporter signature motif; other site 1121448008271 Walker B; other site 1121448008272 D-loop; other site 1121448008273 H-loop/switch region; other site 1121448008274 HlyD family secretion protein; Region: HlyD; pfam00529 1121448008275 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1121448008276 HlyD family secretion protein; Region: HlyD_3; pfam13437 1121448008277 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1121448008278 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1121448008279 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1121448008280 acyl-activating enzyme (AAE) consensus motif; other site 1121448008281 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 1121448008282 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1121448008283 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1121448008284 active site 1121448008285 aminotransferase; Validated; Region: PRK08175 1121448008286 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1121448008287 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1121448008288 homodimer interface [polypeptide binding]; other site 1121448008289 catalytic residue [active] 1121448008290 homoserine dehydrogenase; Provisional; Region: PRK06349 1121448008291 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1121448008292 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1121448008293 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 1121448008294 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: PhosphMutase; cl17294 1121448008295 cofactor-independent phosphoglycerate mutase; Provisional; Region: PRK04200 1121448008296 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1121448008297 active site 1121448008298 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 1121448008299 hypothetical protein; Validated; Region: PRK00110 1121448008300 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 1121448008301 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1121448008302 S-adenosylmethionine binding site [chemical binding]; other site 1121448008303 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 1121448008304 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 1121448008305 Clp amino terminal domain; Region: Clp_N; pfam02861 1121448008306 Clp amino terminal domain; Region: Clp_N; pfam02861 1121448008307 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1121448008308 Walker A motif; other site 1121448008309 ATP binding site [chemical binding]; other site 1121448008310 Walker B motif; other site 1121448008311 arginine finger; other site 1121448008312 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1121448008313 Walker A motif; other site 1121448008314 ATP binding site [chemical binding]; other site 1121448008315 Walker B motif; other site 1121448008316 arginine finger; other site 1121448008317 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1121448008318 MerR HTH family regulatory protein; Region: MerR_2; pfam13591 1121448008319 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1121448008320 DNA binding residues [nucleotide binding] 1121448008321 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 1121448008322 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1121448008323 HSP70 interaction site [polypeptide binding]; other site 1121448008324 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1121448008325 substrate binding site [polypeptide binding]; other site 1121448008326 dimer interface [polypeptide binding]; other site 1121448008327 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 1121448008328 Ligand Binding Site [chemical binding]; other site 1121448008329 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1121448008330 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1121448008331 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1121448008332 dimer interface [polypeptide binding]; other site 1121448008333 putative CheW interface [polypeptide binding]; other site 1121448008334 malate synthase G; Provisional; Region: PRK02999 1121448008335 active site 1121448008336 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1121448008337 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1121448008338 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1121448008339 HlyD family secretion protein; Region: HlyD_3; pfam13437 1121448008340 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1121448008341 CheB methylesterase; Region: CheB_methylest; pfam01339 1121448008342 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 1121448008343 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 1121448008344 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 1121448008345 PAS domain; Region: PAS_10; pfam13596 1121448008346 PAS fold; Region: PAS_4; pfam08448 1121448008347 PAS domain S-box; Region: sensory_box; TIGR00229 1121448008348 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121448008349 putative active site [active] 1121448008350 heme pocket [chemical binding]; other site 1121448008351 PAS fold; Region: PAS; pfam00989 1121448008352 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1121448008353 dimer interface [polypeptide binding]; other site 1121448008354 phosphorylation site [posttranslational modification] 1121448008355 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121448008356 ATP binding site [chemical binding]; other site 1121448008357 Mg2+ binding site [ion binding]; other site 1121448008358 G-X-G motif; other site 1121448008359 Response regulator receiver domain; Region: Response_reg; pfam00072 1121448008360 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121448008361 active site 1121448008362 phosphorylation site [posttranslational modification] 1121448008363 intermolecular recognition site; other site 1121448008364 dimerization interface [polypeptide binding]; other site 1121448008365 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 1121448008366 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 1121448008367 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1121448008368 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1121448008369 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1121448008370 dimerization interface [polypeptide binding]; other site 1121448008371 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1121448008372 ATP12 chaperone protein; Region: ATP12; cl02228 1121448008373 Divergent AAA domain; Region: AAA_4; pfam04326 1121448008374 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 1121448008375 homodimer interface [polypeptide binding]; other site 1121448008376 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 1121448008377 active site pocket [active] 1121448008378 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 1121448008379 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1121448008380 This family is most closely related to the GT1 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II); Region: GT1_ExpE7_like; cd03823 1121448008381 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1121448008382 Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130 1121448008383 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 1121448008384 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 1121448008385 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1121448008386 Zn2+ binding site [ion binding]; other site 1121448008387 Mg2+ binding site [ion binding]; other site 1121448008388 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1121448008389 PhoH-like protein; Region: PhoH; pfam02562 1121448008390 Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; pfam10087 1121448008391 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 1121448008392 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1121448008393 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 1121448008394 active site 1121448008395 multimer interface [polypeptide binding]; other site 1121448008396 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 1121448008397 NodB motif; other site 1121448008398 putative active site [active] 1121448008399 putative catalytic site [active] 1121448008400 Zn binding site [ion binding]; other site 1121448008401 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 1121448008402 C-terminal peptidase (prc); Region: prc; TIGR00225 1121448008403 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1121448008404 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 1121448008405 Catalytic dyad [active] 1121448008406 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 1121448008407 Peptidase family M23; Region: Peptidase_M23; pfam01551 1121448008408 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1121448008409 endonuclease III; Region: ENDO3c; smart00478 1121448008410 minor groove reading motif; other site 1121448008411 helix-hairpin-helix signature motif; other site 1121448008412 substrate binding pocket [chemical binding]; other site 1121448008413 active site 1121448008414 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 1121448008415 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1121448008416 S-adenosylmethionine binding site [chemical binding]; other site 1121448008417 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 1121448008418 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1121448008419 thiazole biosynthesis adenylyltransferase ThiF, E. coli subfamily; Region: adenyl_thiF; TIGR02356 1121448008420 ATP binding site [chemical binding]; other site 1121448008421 substrate interface [chemical binding]; other site 1121448008422 Ubiquitin-like proteins; Region: UBQ; cl00155 1121448008423 charged pocket; other site 1121448008424 hydrophobic patch; other site 1121448008425 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 1121448008426 Protein export membrane protein; Region: SecD_SecF; pfam02355 1121448008427 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 1121448008428 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 1121448008429 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 1121448008430 Preprotein translocase subunit; Region: YajC; pfam02699 1121448008431 Archaeal-type gltB domain. This domain shares sequence similarity with a region of unknown function found in the large subunit of glutamate synthase, which is encoded by gltB and found in most bacteria and eukaryotes. It is predicted to be homologous to...; Region: arch_gltB; cd00981 1121448008432 putative subunit interface; other site 1121448008433 Glutamate synthase domain 1 [Amino acid transport and metabolism]; Region: GltB; COG0067 1121448008434 Glutamine amidotransferases class-II (Gn-AT)_GlxB-type. GlxB is a glutamine amidotransferase-like protein of unknown function found in bacteria and archaea. GlxB has a structural fold similar to that of other class II glutamine amidotransferases...; Region: GlxB; cd01907 1121448008435 putative active site [active] 1121448008436 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 1121448008437 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1121448008438 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 1121448008439 Conserved region in glutamate synthase; Region: Glu_synthase; pfam01645 1121448008440 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1121448008441 active site 1121448008442 FMN binding site [chemical binding]; other site 1121448008443 substrate binding site [chemical binding]; other site 1121448008444 3Fe-4S cluster binding site [ion binding]; other site 1121448008445 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1121448008446 dimerization interface [polypeptide binding]; other site 1121448008447 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1121448008448 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1121448008449 dimer interface [polypeptide binding]; other site 1121448008450 putative CheW interface [polypeptide binding]; other site 1121448008451 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 1121448008452 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1121448008453 active site 1121448008454 N-ethylammeline chlorohydrolase; Provisional; Region: PRK09045 1121448008455 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 1121448008456 active site 1121448008457 putative substrate binding pocket [chemical binding]; other site 1121448008458 N-ethylammeline chlorohydrolase; Provisional; Region: PRK09045 1121448008459 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 1121448008460 active site 1121448008461 putative substrate binding pocket [chemical binding]; other site 1121448008462 diaminopimelate aminotransferase; Provisional; Region: PRK13983 1121448008463 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like1; cd05650 1121448008464 metal binding site [ion binding]; metal-binding site 1121448008465 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 1121448008466 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 1121448008467 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 1121448008468 Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535 1121448008469 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1121448008470 Transporter associated domain; Region: CorC_HlyC; smart01091 1121448008471 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 1121448008472 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 1121448008473 putative active site [active] 1121448008474 catalytic triad [active] 1121448008475 putative dimer interface [polypeptide binding]; other site 1121448008476 PCRF domain; Region: PCRF; pfam03462 1121448008477 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 1121448008478 RF-1 domain; Region: RF-1; pfam00472 1121448008479 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1121448008480 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1121448008481 metal binding site [ion binding]; metal-binding site 1121448008482 active site 1121448008483 I-site; other site 1121448008484 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 1121448008485 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 1121448008486 P-loop; other site 1121448008487 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 1121448008488 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1121448008489 IHF - DNA interface [nucleotide binding]; other site 1121448008490 IHF dimer interface [polypeptide binding]; other site 1121448008491 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1121448008492 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 1121448008493 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1121448008494 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1121448008495 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1121448008496 dihydrodipicolinate synthase; Region: dapA; TIGR00674 1121448008497 dimer interface [polypeptide binding]; other site 1121448008498 active site 1121448008499 catalytic residue [active] 1121448008500 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 1121448008501 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1121448008502 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 1121448008503 tricarballylate utilization protein B; Provisional; Region: PRK15033 1121448008504 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959 1121448008505 Myosin tail; Region: Myosin_tail_1; pfam01576 1121448008506 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 1121448008507 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 1121448008508 Mg++ binding site [ion binding]; other site 1121448008509 putative catalytic motif [active] 1121448008510 substrate binding site [chemical binding]; other site 1121448008511 Chorismate mutase type II; Region: CM_2; cl00693 1121448008512 Bacterial protein of unknown function (DUF898); Region: DUF898; cl01738 1121448008513 Protein of unknown function (DUF401); Region: DUF401; cl00830 1121448008514 BNR repeat-like domain; Region: BNR_2; pfam13088 1121448008515 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 1121448008516 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl15777 1121448008517 putative active site pocket [active] 1121448008518 dimerization interface [polypeptide binding]; other site 1121448008519 putative catalytic residue [active] 1121448008520 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 1121448008521 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1121448008522 active site 1121448008523 HIGH motif; other site 1121448008524 nucleotide binding site [chemical binding]; other site 1121448008525 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1121448008526 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1121448008527 active site 1121448008528 KMSKS motif; other site 1121448008529 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 1121448008530 tRNA binding surface [nucleotide binding]; other site 1121448008531 anticodon binding site; other site 1121448008532 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1121448008533 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 1121448008534 lipoprotein signal peptidase; Provisional; Region: PRK14787 1121448008535 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 1121448008536 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1121448008537 binding surface 1121448008538 TPR motif; other site 1121448008539 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 1121448008540 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 1121448008541 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 1121448008542 Chemotaxis phosphatase, CheZ; Region: CheZ; cl01219 1121448008543 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 1121448008544 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1121448008545 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1121448008546 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 1121448008547 Putative zinc ribbon domain; Region: DUF164; pfam02591 1121448008548 bifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase protein; Provisional; Region: ispDF; PRK09382 1121448008549 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1121448008550 substrate binding site; other site 1121448008551 dimer interface; other site 1121448008552 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 1121448008553 homotrimer interaction site [polypeptide binding]; other site 1121448008554 zinc binding site [ion binding]; other site 1121448008555 CDP-binding sites; other site 1121448008556 ACT domain-containing protein [General function prediction only]; Region: COG4747 1121448008557 N-terminal ACT domain of a novel protein composed almost entirely of two tandem ACT domains; Region: ACT_Bt0572_1; cd04908 1121448008558 C-terminal ACT domain of a novel protein composed of just two ACT domains; Region: ACT_Bt0572_2; cd04882 1121448008559 dihydrodipicolinate reductase; Provisional; Region: PRK00048 1121448008560 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1121448008561 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1121448008562 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 1121448008563 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1121448008564 nucleotide binding pocket [chemical binding]; other site 1121448008565 K-X-D-G motif; other site 1121448008566 catalytic site [active] 1121448008567 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1121448008568 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 1121448008569 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1121448008570 Dimer interface [polypeptide binding]; other site 1121448008571 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1121448008572 active site 1121448008573 Ion channel; Region: Ion_trans_2; pfam07885 1121448008574 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1121448008575 TrkA-N domain; Region: TrkA_N; pfam02254 1121448008576 TrkA-C domain; Region: TrkA_C; pfam02080 1121448008577 excinuclease ABC subunit B; Provisional; Region: PRK05298 1121448008578 Myosin and Kinesin motor domain. These ATPases belong to the P-loop NTPase family and provide the driving force in myosin and kinesin mediated processes; Region: Motor_domain; cl00286 1121448008579 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1121448008580 ATP-binding site [chemical binding]; other site 1121448008581 ATP binding site [chemical binding]; other site 1121448008582 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1121448008583 nucleotide binding region [chemical binding]; other site 1121448008584 ATP-binding site [chemical binding]; other site 1121448008585 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1121448008586 UvrB/uvrC motif; Region: UVR; pfam02151 1121448008587 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 1121448008588 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1121448008589 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 1121448008590 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 1121448008591 TPP-binding site; other site 1121448008592 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1121448008593 PYR/PP interface [polypeptide binding]; other site 1121448008594 dimer interface [polypeptide binding]; other site 1121448008595 TPP binding site [chemical binding]; other site 1121448008596 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1121448008597 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1121448008598 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1121448008599 substrate binding pocket [chemical binding]; other site 1121448008600 chain length determination region; other site 1121448008601 substrate-Mg2+ binding site; other site 1121448008602 catalytic residues [active] 1121448008603 aspartate-rich region 1; other site 1121448008604 active site lid residues [active] 1121448008605 aspartate-rich region 2; other site 1121448008606 Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750 1121448008607 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 1121448008608 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1121448008609 generic binding surface II; other site 1121448008610 generic binding surface I; other site 1121448008611 prolyl-tRNA synthetase; Provisional; Region: PRK09194 1121448008612 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 1121448008613 dimer interface [polypeptide binding]; other site 1121448008614 motif 1; other site 1121448008615 active site 1121448008616 motif 2; other site 1121448008617 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 1121448008618 putative deacylase active site [active] 1121448008619 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1121448008620 active site 1121448008621 motif 3; other site 1121448008622 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 1121448008623 anticodon binding site; other site 1121448008624 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 1121448008625 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1121448008626 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1121448008627 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 1121448008628 dimerization interface [polypeptide binding]; other site 1121448008629 putative ATP binding site [chemical binding]; other site 1121448008630 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1121448008631 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1121448008632 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 1121448008633 putative dimerization interface [polypeptide binding]; other site 1121448008634 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 1121448008635 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1121448008636 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1121448008637 alphaNTD - beta interaction site [polypeptide binding]; other site 1121448008638 alphaNTD homodimer interface [polypeptide binding]; other site 1121448008639 alphaNTD - beta' interaction site [polypeptide binding]; other site 1121448008640 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1121448008641 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1121448008642 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1121448008643 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1121448008644 RNA binding surface [nucleotide binding]; other site 1121448008645 30S ribosomal protein S11; Validated; Region: PRK05309 1121448008646 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 1121448008647 30S ribosomal protein S13; Region: bact_S13; TIGR03631 1121448008648 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 1121448008649 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1121448008650 active site 1121448008651 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1121448008652 SecY translocase; Region: SecY; pfam00344 1121448008653 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1121448008654 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 1121448008655 23S rRNA binding site [nucleotide binding]; other site 1121448008656 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 1121448008657 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1121448008658 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1121448008659 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1121448008660 5S rRNA interface [nucleotide binding]; other site 1121448008661 23S rRNA interface [nucleotide binding]; other site 1121448008662 L5 interface [polypeptide binding]; other site 1121448008663 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1121448008664 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1121448008665 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1121448008666 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 1121448008667 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 1121448008668 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1121448008669 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1121448008670 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1121448008671 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1121448008672 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1121448008673 RNA binding site [nucleotide binding]; other site 1121448008674 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 1121448008675 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1121448008676 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1121448008677 23S rRNA interface [nucleotide binding]; other site 1121448008678 putative translocon interaction site; other site 1121448008679 signal recognition particle (SRP54) interaction site; other site 1121448008680 L23 interface [polypeptide binding]; other site 1121448008681 trigger factor interaction site; other site 1121448008682 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1121448008683 23S rRNA interface [nucleotide binding]; other site 1121448008684 5S rRNA interface [nucleotide binding]; other site 1121448008685 putative antibiotic binding site [chemical binding]; other site 1121448008686 L25 interface [polypeptide binding]; other site 1121448008687 L27 interface [polypeptide binding]; other site 1121448008688 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1121448008689 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1121448008690 G-X-X-G motif; other site 1121448008691 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1121448008692 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1121448008693 putative translocon binding site; other site 1121448008694 protein-rRNA interface [nucleotide binding]; other site 1121448008695 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 1121448008696 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1121448008697 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1121448008698 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1121448008699 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1121448008700 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 1121448008701 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 1121448008702 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1121448008703 elongation factor G; Reviewed; Region: PRK00007 1121448008704 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1121448008705 G1 box; other site 1121448008706 putative GEF interaction site [polypeptide binding]; other site 1121448008707 GTP/Mg2+ binding site [chemical binding]; other site 1121448008708 Switch I region; other site 1121448008709 G2 box; other site 1121448008710 G3 box; other site 1121448008711 Switch II region; other site 1121448008712 G4 box; other site 1121448008713 G5 box; other site 1121448008714 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1121448008715 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1121448008716 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1121448008717 30S ribosomal protein S7; Validated; Region: PRK05302 1121448008718 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1121448008719 S17 interaction site [polypeptide binding]; other site 1121448008720 S8 interaction site; other site 1121448008721 16S rRNA interaction site [nucleotide binding]; other site 1121448008722 streptomycin interaction site [chemical binding]; other site 1121448008723 23S rRNA interaction site [nucleotide binding]; other site 1121448008724 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1121448008725 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1121448008726 active site 1121448008727 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1121448008728 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1121448008729 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1121448008730 active site 1121448008731 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1121448008732 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1121448008733 SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105 1121448008734 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1121448008735 Ligand Binding Site [chemical binding]; other site 1121448008736 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1121448008737 Ligand Binding Site [chemical binding]; other site 1121448008738 Na+/H+ ion antiporter subunit; Region: MNHE; pfam01899 1121448008739 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12599 1121448008740 Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; pfam03334 1121448008741 Domain of unknown function (DUF4040); Region: DUF4040; pfam13244 1121448008742 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 1121448008743 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK07375 1121448008744 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK08375 1121448008745 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1121448008746 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK08375 1121448008747 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1121448008748 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12668 1121448008749 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1121448008750 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1121448008751 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1121448008752 ligand binding site [chemical binding]; other site 1121448008753 flexible hinge region; other site 1121448008754 Domain of unknown function (DUF814); Region: DUF814; pfam05670 1121448008755 RNA polymerase-binding protein DksA; Region: dksA; TIGR02420 1121448008756 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1121448008757 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 1121448008758 Ferritin-like domain; Region: Ferritin; pfam00210 1121448008759 heme binding site [chemical binding]; other site 1121448008760 ferroxidase pore; other site 1121448008761 ferroxidase diiron center [ion binding]; other site 1121448008762 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 1121448008763 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 1121448008764 tetramer interface [polypeptide binding]; other site 1121448008765 heme binding pocket [chemical binding]; other site 1121448008766 NADPH binding site [chemical binding]; other site 1121448008767 penicillin-binding protein 1C; Region: PBP_1c; TIGR02073 1121448008768 Transglycosylase; Region: Transgly; pfam00912 1121448008769 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1121448008770 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 1121448008771 Bacterial Ig-like domain; Region: Big_5; pfam13205 1121448008772 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 1121448008773 MG2 domain; Region: A2M_N; pfam01835 1121448008774 Alpha-2-macroglobulin family; Region: A2M; pfam00207 1121448008775 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 1121448008776 surface patch; other site 1121448008777 thioester region; other site 1121448008778 specificity defining residues; other site 1121448008779 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1121448008780 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1121448008781 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1121448008782 catalytic residue [active] 1121448008783 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 1121448008784 putative FMN binding site [chemical binding]; other site 1121448008785 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 1121448008786 Predicted periplasmic protein (DUF2092); Region: DUF2092; cl17607 1121448008787 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1121448008788 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1121448008789 zinc-ribbon domain; Region: zinc_ribbon_5; pfam13719 1121448008790 Uncharacterized protein conserved in archaea [Function unknown]; Region: COG2881 1121448008791 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 1121448008792 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1121448008793 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1121448008794 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1121448008795 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1121448008796 active site residue [active] 1121448008797 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 1121448008798 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 1121448008799 DNA binding site [nucleotide binding] 1121448008800 catalytic residue [active] 1121448008801 H2TH interface [polypeptide binding]; other site 1121448008802 putative catalytic residues [active] 1121448008803 turnover-facilitating residue; other site 1121448008804 intercalation triad [nucleotide binding]; other site 1121448008805 8OG recognition residue [nucleotide binding]; other site 1121448008806 putative reading head residues; other site 1121448008807 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1121448008808 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1121448008809 Protein of unknown function, DUF399; Region: DUF399; pfam04187 1121448008810 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1121448008811 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 1121448008812 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1121448008813 acyl-activating enzyme (AAE) consensus motif; other site 1121448008814 AMP binding site [chemical binding]; other site 1121448008815 active site 1121448008816 CoA binding site [chemical binding]; other site 1121448008817 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1121448008818 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 1121448008819 Radical SAM superfamily; Region: Radical_SAM; pfam04055 1121448008820 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1121448008821 FeS/SAM binding site; other site 1121448008822 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 1121448008823 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1121448008824 homodimer interface [polypeptide binding]; other site 1121448008825 oligonucleotide binding site [chemical binding]; other site 1121448008826 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases and ATP sulphurylases. The domain forms a apha/beta/apha fold which binds to Adenosine group; Region: Alpha_ANH_like; cd01986 1121448008827 Ligand Binding Site [chemical binding]; other site 1121448008828 coproporphyrinogen III oxidase; Provisional; Region: PRK09057 1121448008829 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1121448008830 FeS/SAM binding site; other site 1121448008831 HemN C-terminal domain; Region: HemN_C; pfam06969 1121448008832 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1121448008833 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 1121448008834 Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090 1121448008835 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 1121448008836 Uncharacterized protein conserved in bacteria (DUF2264); Region: DUF2264; cl01752 1121448008837 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 1121448008838 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1121448008839 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 1121448008840 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 1121448008841 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1121448008842 Walker A/P-loop; other site 1121448008843 ATP binding site [chemical binding]; other site 1121448008844 Q-loop/lid; other site 1121448008845 ABC transporter signature motif; other site 1121448008846 Walker B; other site 1121448008847 D-loop; other site 1121448008848 H-loop/switch region; other site 1121448008849 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1121448008850 Walker A/P-loop; other site 1121448008851 ATP binding site [chemical binding]; other site 1121448008852 Q-loop/lid; other site 1121448008853 ABC transporter signature motif; other site 1121448008854 Walker B; other site 1121448008855 D-loop; other site 1121448008856 H-loop/switch region; other site 1121448008857 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1121448008858 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 1121448008859 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121448008860 dimer interface [polypeptide binding]; other site 1121448008861 conserved gate region; other site 1121448008862 ABC-ATPase subunit interface; other site 1121448008863 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 1121448008864 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121448008865 dimer interface [polypeptide binding]; other site 1121448008866 conserved gate region; other site 1121448008867 putative PBP binding loops; other site 1121448008868 ABC-ATPase subunit interface; other site 1121448008869 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1121448008870 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 1121448008871 S-adenosylmethionine decarboxylase proenzyme, Bacillus form; Region: SAM_DCase_Bsu; TIGR03330 1121448008872 FIST N domain; Region: FIST; cl10701 1121448008873 FIST C domain; Region: FIST_C; pfam10442 1121448008874 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1121448008875 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121448008876 putative active site [active] 1121448008877 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1121448008878 heme pocket [chemical binding]; other site 1121448008879 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1121448008880 dimer interface [polypeptide binding]; other site 1121448008881 phosphorylation site [posttranslational modification] 1121448008882 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121448008883 ATP binding site [chemical binding]; other site 1121448008884 Mg2+ binding site [ion binding]; other site 1121448008885 G-X-G motif; other site 1121448008886 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1121448008887 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121448008888 putative active site [active] 1121448008889 heme pocket [chemical binding]; other site 1121448008890 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1121448008891 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1121448008892 dimer interface [polypeptide binding]; other site 1121448008893 phosphorylation site [posttranslational modification] 1121448008894 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121448008895 ATP binding site [chemical binding]; other site 1121448008896 Mg2+ binding site [ion binding]; other site 1121448008897 G-X-G motif; other site 1121448008898 Response regulator receiver domain; Region: Response_reg; pfam00072 1121448008899 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121448008900 active site 1121448008901 phosphorylation site [posttranslational modification] 1121448008902 intermolecular recognition site; other site 1121448008903 dimerization interface [polypeptide binding]; other site 1121448008904 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1121448008905 putative binding surface; other site 1121448008906 active site 1121448008907 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1121448008908 active site 1121448008909 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1121448008910 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1121448008911 RNA binding surface [nucleotide binding]; other site 1121448008912 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1121448008913 active site 1121448008914 dephospho-CoA kinase; Region: TIGR00152 1121448008915 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1121448008916 CoA-binding site [chemical binding]; other site 1121448008917 ATP-binding [chemical binding]; other site 1121448008918 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 1121448008919 PBP superfamily domain; Region: PBP_like_2; cl17296 1121448008920 Phosphate ATP-binding cassette transporter; Region: DUF3708; pfam12501 1121448008921 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 1121448008922 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121448008923 dimer interface [polypeptide binding]; other site 1121448008924 conserved gate region; other site 1121448008925 putative PBP binding loops; other site 1121448008926 ABC-ATPase subunit interface; other site 1121448008927 Domain of unknown function (DUF3333); Region: DUF3333; pfam11812 1121448008928 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 1121448008929 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121448008930 dimer interface [polypeptide binding]; other site 1121448008931 conserved gate region; other site 1121448008932 putative PBP binding loops; other site 1121448008933 ABC-ATPase subunit interface; other site 1121448008934 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 1121448008935 PIN domain; Region: PIN_Smg5-Smg6-like; cd09880 1121448008936 putative active site [active] 1121448008937 PhoH-like protein; Region: PhoH; cl17668 1121448008938 Metal binding protein ZntC. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: ZntC; cd01018 1121448008939 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 1121448008940 putative metal binding residues [ion binding]; other site 1121448008941 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1121448008942 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1121448008943 Walker A/P-loop; other site 1121448008944 ATP binding site [chemical binding]; other site 1121448008945 Q-loop/lid; other site 1121448008946 ABC transporter signature motif; other site 1121448008947 Walker B; other site 1121448008948 D-loop; other site 1121448008949 H-loop/switch region; other site 1121448008950 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1121448008951 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1121448008952 ABC-ATPase subunit interface; other site 1121448008953 dimer interface [polypeptide binding]; other site 1121448008954 putative PBP binding regions; other site 1121448008955 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1121448008956 metal binding site 2 [ion binding]; metal-binding site 1121448008957 putative DNA binding helix; other site 1121448008958 metal binding site 1 [ion binding]; metal-binding site 1121448008959 dimer interface [polypeptide binding]; other site 1121448008960 structural Zn2+ binding site [ion binding]; other site 1121448008961 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1121448008962 TPR repeat; Region: TPR_11; pfam13414 1121448008963 binding surface 1121448008964 Predicted transcriptional regulator [Transcription]; Region: COG2932 1121448008965 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462 1121448008966 Catalytic site [active] 1121448008967 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1121448008968 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1121448008969 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1121448008970 putative substrate translocation pore; other site 1121448008971 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1121448008972 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1121448008973 Ligand binding site; other site 1121448008974 Putative Catalytic site; other site 1121448008975 DXD motif; other site 1121448008976 Predicted integral membrane protein [Function unknown]; Region: COG5542 1121448008977 Predicted integral membrane protein [Function unknown]; Region: COG5542 1121448008978 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1121448008979 Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457 1121448008980 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1121448008981 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1121448008982 catalytic residue [active] 1121448008983 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 1121448008984 Cache domain; Region: Cache_1; pfam02743 1121448008985 HAMP domain; Region: HAMP; pfam00672 1121448008986 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 1121448008987 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1121448008988 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1121448008989 active site 1121448008990 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1121448008991 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121448008992 putative active site [active] 1121448008993 heme pocket [chemical binding]; other site 1121448008994 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1121448008995 dimer interface [polypeptide binding]; other site 1121448008996 phosphorylation site [posttranslational modification] 1121448008997 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121448008998 ATP binding site [chemical binding]; other site 1121448008999 Mg2+ binding site [ion binding]; other site 1121448009000 G-X-G motif; other site 1121448009001 histidinol-phosphatase; Provisional; Region: PRK07328 1121448009002 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 1121448009003 active site 1121448009004 dimer interface [polypeptide binding]; other site 1121448009005 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1121448009006 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 1121448009007 putative acyl-acceptor binding pocket; other site 1121448009008 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444 1121448009009 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 1121448009010 ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA [Inorganic ion transport and metabolism]; Region: ModF; COG1119 1121448009011 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1121448009012 Walker A/P-loop; other site 1121448009013 ATP binding site [chemical binding]; other site 1121448009014 Q-loop/lid; other site 1121448009015 ABC transporter signature motif; other site 1121448009016 Walker B; other site 1121448009017 D-loop; other site 1121448009018 H-loop/switch region; other site 1121448009019 ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA [Inorganic ion transport and metabolism]; Region: ModF; COG1119 1121448009020 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1121448009021 Walker A/P-loop; other site 1121448009022 ATP binding site [chemical binding]; other site 1121448009023 Q-loop/lid; other site 1121448009024 ABC transporter signature motif; other site 1121448009025 Walker B; other site 1121448009026 D-loop; other site 1121448009027 H-loop/switch region; other site 1121448009028 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1121448009029 phosphate binding site [ion binding]; other site 1121448009030 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121448009031 PAS domain; Region: PAS_9; pfam13426 1121448009032 putative active site [active] 1121448009033 heme pocket [chemical binding]; other site 1121448009034 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 1121448009035 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1121448009036 Walker A motif; other site 1121448009037 ATP binding site [chemical binding]; other site 1121448009038 Walker B motif; other site 1121448009039 arginine finger; other site 1121448009040 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1121448009041 This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. This...; Region: NifX_NifB; cl00252 1121448009042 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1121448009043 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1121448009044 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 1121448009045 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 1121448009046 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1121448009047 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121448009048 putative active site [active] 1121448009049 heme pocket [chemical binding]; other site 1121448009050 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1121448009051 dimer interface [polypeptide binding]; other site 1121448009052 phosphorylation site [posttranslational modification] 1121448009053 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121448009054 ATP binding site [chemical binding]; other site 1121448009055 Mg2+ binding site [ion binding]; other site 1121448009056 G-X-G motif; other site 1121448009057 Response regulator receiver domain; Region: Response_reg; pfam00072 1121448009058 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121448009059 active site 1121448009060 phosphorylation site [posttranslational modification] 1121448009061 intermolecular recognition site; other site 1121448009062 dimerization interface [polypeptide binding]; other site 1121448009063 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1121448009064 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1121448009065 Predicted protein-tyrosine phosphatase [Signal transduction mechanisms]; Region: CDC14; COG2453 1121448009066 active site 1121448009067 catalytic residues [active] 1121448009068 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1121448009069 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1121448009070 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1121448009071 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1121448009072 Walker A/P-loop; other site 1121448009073 ATP binding site [chemical binding]; other site 1121448009074 Q-loop/lid; other site 1121448009075 ABC transporter signature motif; other site 1121448009076 Walker B; other site 1121448009077 D-loop; other site 1121448009078 H-loop/switch region; other site 1121448009079 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1121448009080 HlyD family secretion protein; Region: HlyD_3; pfam13437 1121448009081 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 1121448009082 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051 1121448009083 EF-hand domain pair; Region: EF_hand_5; pfam13499 1121448009084 Ca2+ binding site [ion binding]; other site 1121448009085 hopanoid biosynthesis associated radical SAM protein HpnJ; Region: HpnJ; TIGR03471 1121448009086 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 1121448009087 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1121448009088 FeS/SAM binding site; other site 1121448009089 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1121448009090 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1121448009091 active site 1121448009092 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 1121448009093 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 1121448009094 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 1121448009095 Chain length determinant protein; Region: Wzz; cl15801 1121448009096 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 1121448009097 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1121448009098 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1121448009099 active site 1121448009100 ATP binding site [chemical binding]; other site 1121448009101 substrate binding site [chemical binding]; other site 1121448009102 activation loop (A-loop); other site 1121448009103 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12647 1121448009104 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 1121448009105 nucleophile elbow; other site 1121448009106 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 1121448009107 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1121448009108 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181 1121448009109 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1121448009110 Walker A/P-loop; other site 1121448009111 ATP binding site [chemical binding]; other site 1121448009112 Q-loop/lid; other site 1121448009113 ABC transporter signature motif; other site 1121448009114 Walker B; other site 1121448009115 D-loop; other site 1121448009116 H-loop/switch region; other site 1121448009117 putative acetyltransferase; Provisional; Region: PRK03624 1121448009118 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1121448009119 Coenzyme A binding pocket [chemical binding]; other site 1121448009120 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1121448009121 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1121448009122 substrate binding pocket [chemical binding]; other site 1121448009123 membrane-bound complex binding site; other site 1121448009124 hinge residues; other site 1121448009125 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1121448009126 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1121448009127 substrate binding pocket [chemical binding]; other site 1121448009128 membrane-bound complex binding site; other site 1121448009129 hinge residues; other site 1121448009130 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1121448009131 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1121448009132 substrate binding pocket [chemical binding]; other site 1121448009133 membrane-bound complex binding site; other site 1121448009134 hinge residues; other site 1121448009135 PAS domain S-box; Region: sensory_box; TIGR00229 1121448009136 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121448009137 putative active site [active] 1121448009138 heme pocket [chemical binding]; other site 1121448009139 PAS fold; Region: PAS_4; pfam08448 1121448009140 PAS domain S-box; Region: sensory_box; TIGR00229 1121448009141 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121448009142 putative active site [active] 1121448009143 heme pocket [chemical binding]; other site 1121448009144 Predicted hydrocarbon binding protein (contains V4R domain) [General function prediction only]; Region: COG1719 1121448009145 The V4R (vinyl 4 reductase) domain is a predicted small molecular binding domain, that may bind to hydrocarbons; Region: V4R; smart00989 1121448009146 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 1121448009147 dimerization interface [polypeptide binding]; other site 1121448009148 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1121448009149 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1121448009150 dimer interface [polypeptide binding]; other site 1121448009151 phosphorylation site [posttranslational modification] 1121448009152 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121448009153 ATP binding site [chemical binding]; other site 1121448009154 Mg2+ binding site [ion binding]; other site 1121448009155 G-X-G motif; other site 1121448009156 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121448009157 Response regulator receiver domain; Region: Response_reg; pfam00072 1121448009158 active site 1121448009159 phosphorylation site [posttranslational modification] 1121448009160 intermolecular recognition site; other site 1121448009161 dimerization interface [polypeptide binding]; other site 1121448009162 Response regulator receiver domain; Region: Response_reg; pfam00072 1121448009163 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121448009164 active site 1121448009165 phosphorylation site [posttranslational modification] 1121448009166 intermolecular recognition site; other site 1121448009167 dimerization interface [polypeptide binding]; other site 1121448009168 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1121448009169 putative binding surface; other site 1121448009170 active site 1121448009171 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 1121448009172 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121448009173 active site 1121448009174 phosphorylation site [posttranslational modification] 1121448009175 intermolecular recognition site; other site 1121448009176 dimerization interface [polypeptide binding]; other site 1121448009177 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1121448009178 Zn2+ binding site [ion binding]; other site 1121448009179 Mg2+ binding site [ion binding]; other site 1121448009180 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1121448009181 DNA-binding site [nucleotide binding]; DNA binding site 1121448009182 RNA-binding motif; other site 1121448009183 HDOD domain; Region: HDOD; pfam08668 1121448009184 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1121448009185 Zn2+ binding site [ion binding]; other site 1121448009186 Mg2+ binding site [ion binding]; other site 1121448009187 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 1121448009188 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1121448009189 homodimer interface [polypeptide binding]; other site 1121448009190 substrate-cofactor binding pocket; other site 1121448009191 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1121448009192 catalytic residue [active] 1121448009193 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 1121448009194 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1121448009195 homodimer interface [polypeptide binding]; other site 1121448009196 substrate-cofactor binding pocket; other site 1121448009197 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1121448009198 catalytic residue [active] 1121448009199 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121448009200 Response regulator receiver domain; Region: Response_reg; pfam00072 1121448009201 active site 1121448009202 phosphorylation site [posttranslational modification] 1121448009203 intermolecular recognition site; other site 1121448009204 dimerization interface [polypeptide binding]; other site 1121448009205 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121448009206 PAS fold; Region: PAS_3; pfam08447 1121448009207 putative active site [active] 1121448009208 heme pocket [chemical binding]; other site 1121448009209 sensor protein ZraS; Provisional; Region: PRK10364 1121448009210 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1121448009211 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1121448009212 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1121448009213 metal binding site [ion binding]; metal-binding site 1121448009214 active site 1121448009215 I-site; other site 1121448009216 CobD/Cbib protein; Region: CobD_Cbib; pfam03186 1121448009217 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1121448009218 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1121448009219 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1121448009220 substrate binding pocket [chemical binding]; other site 1121448009221 Ion channel; Region: Ion_trans_2; pfam07885 1121448009222 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1121448009223 membrane-bound complex binding site; other site 1121448009224 hinge residues; other site 1121448009225 Predicted inhibitor of MCP methylation, homolog of CheC [Cell motility and secretion]; Region: COG1406 1121448009226 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 1121448009227 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1121448009228 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1121448009229 metal-binding site [ion binding] 1121448009230 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1121448009231 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1121448009232 motif II; other site 1121448009233 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1121448009234 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1121448009235 active site 1121448009236 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 1121448009237 arsenical-resistance protein; Region: acr3; TIGR00832 1121448009238 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 1121448009239 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 1121448009240 G1 box; other site 1121448009241 putative GEF interaction site [polypeptide binding]; other site 1121448009242 GTP/Mg2+ binding site [chemical binding]; other site 1121448009243 Switch I region; other site 1121448009244 G2 box; other site 1121448009245 G3 box; other site 1121448009246 Switch II region; other site 1121448009247 G4 box; other site 1121448009248 G5 box; other site 1121448009249 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 1121448009250 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 1121448009251 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 1121448009252 trmE is a tRNA modification GTPase; Region: trmE; cd04164 1121448009253 G1 box; other site 1121448009254 GTP/Mg2+ binding site [chemical binding]; other site 1121448009255 Switch I region; other site 1121448009256 G2 box; other site 1121448009257 Switch II region; other site 1121448009258 G3 box; other site 1121448009259 G4 box; other site 1121448009260 G5 box; other site 1121448009261 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 1121448009262 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 1121448009263 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 1121448009264 G-X-X-G motif; other site 1121448009265 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 1121448009266 RxxxH motif; other site 1121448009267 membrane protein insertase, YidC/Oxa1 family, N-terminal domain; Region: yidC_nterm; TIGR03593 1121448009268 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 1121448009269 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 1121448009270 Uncharacterized conserved protein [Function unknown]; Region: COG0759 1121448009271 Ribonuclease P; Region: Ribonuclease_P; pfam00825 1121448009272 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 1121448009273 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 1121448009274 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1121448009275 FeS/SAM binding site; other site 1121448009276 Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; pfam10105 1121448009277 radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936 1121448009278 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1121448009279 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1121448009280 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1121448009281 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1121448009282 putative binding surface; other site 1121448009283 active site 1121448009284 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 1121448009285 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 1121448009286 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121448009287 ATP binding site [chemical binding]; other site 1121448009288 Mg2+ binding site [ion binding]; other site 1121448009289 G-X-G motif; other site 1121448009290 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 1121448009291 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1121448009292 putative binding surface; other site 1121448009293 active site 1121448009294 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1121448009295 anti sigma factor interaction site; other site 1121448009296 regulatory phosphorylation site [posttranslational modification]; other site 1121448009297 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1121448009298 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1121448009299 Mg2+ binding site [ion binding]; other site 1121448009300 G-X-G motif; other site 1121448009301 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1121448009302 anti sigma factor interaction site; other site 1121448009303 regulatory phosphorylation site [posttranslational modification]; other site 1121448009304 Response regulator receiver domain; Region: Response_reg; pfam00072 1121448009305 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121448009306 active site 1121448009307 phosphorylation site [posttranslational modification] 1121448009308 intermolecular recognition site; other site 1121448009309 dimerization interface [polypeptide binding]; other site 1121448009310 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1121448009311 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 1121448009312 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 1121448009313 substrate binding pocket [chemical binding]; other site 1121448009314 membrane-bound complex binding site; other site 1121448009315 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 1121448009316 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 1121448009317 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 1121448009318 Walker A motif; other site 1121448009319 ATP binding site [chemical binding]; other site 1121448009320 Walker B motif; other site 1121448009321 RNA polymerase-binding protein DksA; Region: dksA; TIGR02420 1121448009322 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1121448009323 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1121448009324 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1121448009325 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1121448009326 active site 1121448009327 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219 1121448009328 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 1121448009329 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1121448009330 Uncharacterized conserved protein [Function unknown]; Region: COG3379 1121448009331 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 1121448009332 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 1121448009333 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1121448009334 Active Sites [active] 1121448009335 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 1121448009336 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1121448009337 active site 1121448009338 O-Antigen ligase; Region: Wzy_C; cl04850 1121448009339 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1121448009340 Protoporphyrinogen oxidase [Coenzyme metabolism]; Region: HemY; COG1232 1121448009341 Uncharacterized conserved protein [Function unknown]; Region: COG2006 1121448009342 Domain of unknown function (DUF362); Region: DUF362; pfam04015 1121448009343 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1121448009344 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1121448009345 acyl-activating enzyme (AAE) consensus motif; other site 1121448009346 AMP binding site [chemical binding]; other site 1121448009347 active site 1121448009348 CoA binding site [chemical binding]; other site 1121448009349 Uncharacterized conserved protein [Function unknown]; Region: COG2006 1121448009350 Domain of unknown function (DUF362); Region: DUF362; pfam04015 1121448009351 Chorismate mutase type II; Region: CM_2; cl00693 1121448009352 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; cl17225 1121448009353 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 1121448009354 active site 1121448009355 dimer interface [polypeptide binding]; other site 1121448009356 metal binding site [ion binding]; metal-binding site 1121448009357 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1121448009358 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1121448009359 ring oligomerisation interface [polypeptide binding]; other site 1121448009360 ATP/Mg binding site [chemical binding]; other site 1121448009361 stacking interactions; other site 1121448009362 hinge regions; other site 1121448009363 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1121448009364 oligomerisation interface [polypeptide binding]; other site 1121448009365 mobile loop; other site 1121448009366 roof hairpin; other site 1121448009367 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 1121448009368 Colicin V production protein; Region: Colicin_V; pfam02674 1121448009369 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 1121448009370 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 1121448009371 homodimer interface [polypeptide binding]; other site 1121448009372 metal binding site [ion binding]; metal-binding site 1121448009373 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 1121448009374 homodimer interface [polypeptide binding]; other site 1121448009375 active site 1121448009376 putative chemical substrate binding site [chemical binding]; other site 1121448009377 metal binding site [ion binding]; metal-binding site 1121448009378 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 1121448009379 active site clefts [active] 1121448009380 zinc binding site [ion binding]; other site 1121448009381 dimer interface [polypeptide binding]; other site 1121448009382 cytidylate kinase; Provisional; Region: cmk; PRK00023 1121448009383 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1121448009384 CMP-binding site; other site 1121448009385 The sites determining sugar specificity; other site 1121448009386 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 1121448009387 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1121448009388 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1121448009389 homodimer interface [polypeptide binding]; other site 1121448009390 catalytic residue [active] 1121448009391 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1121448009392 Ligand Binding Site [chemical binding]; other site 1121448009393 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 1121448009394 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1121448009395 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1121448009396 Competence-damaged protein; Region: CinA; pfam02464 1121448009397 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1121448009398 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1121448009399 Walker A motif; other site 1121448009400 ATP binding site [chemical binding]; other site 1121448009401 Walker B motif; other site 1121448009402 arginine finger; other site 1121448009403 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1121448009404 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1121448009405 Response regulator receiver domain; Region: Response_reg; pfam00072 1121448009406 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121448009407 active site 1121448009408 phosphorylation site [posttranslational modification] 1121448009409 intermolecular recognition site; other site 1121448009410 dimerization interface [polypeptide binding]; other site 1121448009411 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1121448009412 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1121448009413 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1121448009414 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 1121448009415 phosphorylation site [posttranslational modification] 1121448009416 dimer interface [polypeptide binding]; other site 1121448009417 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121448009418 ATP binding site [chemical binding]; other site 1121448009419 Mg2+ binding site [ion binding]; other site 1121448009420 G-X-G motif; other site 1121448009421 Response regulator receiver domain; Region: Response_reg; pfam00072 1121448009422 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121448009423 active site 1121448009424 phosphorylation site [posttranslational modification] 1121448009425 intermolecular recognition site; other site 1121448009426 dimerization interface [polypeptide binding]; other site 1121448009427 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1121448009428 dimer interface [polypeptide binding]; other site 1121448009429 phosphorylation site [posttranslational modification] 1121448009430 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121448009431 ATP binding site [chemical binding]; other site 1121448009432 G-X-G motif; other site 1121448009433 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1121448009434 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1121448009435 Response regulator receiver domain; Region: Response_reg; pfam00072 1121448009436 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121448009437 active site 1121448009438 phosphorylation site [posttranslational modification] 1121448009439 intermolecular recognition site; other site 1121448009440 dimerization interface [polypeptide binding]; other site 1121448009441 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1121448009442 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1121448009443 Walker A/P-loop; other site 1121448009444 ATP binding site [chemical binding]; other site 1121448009445 Q-loop/lid; other site 1121448009446 ABC transporter signature motif; other site 1121448009447 Walker B; other site 1121448009448 D-loop; other site 1121448009449 H-loop/switch region; other site 1121448009450 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 1121448009451 ABC-type tungstate transport system, permease component [Coenzyme metabolism]; Region: TupB; COG2998 1121448009452 PBP superfamily domain; Region: PBP_like_2; pfam12849 1121448009453 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 1121448009454 Uncharacterized conserved protein [Function unknown]; Region: COG0432 1121448009455 CheD chemotactic sensory transduction; Region: CheD; cl00810 1121448009456 Response regulator receiver domain; Region: Response_reg; pfam00072 1121448009457 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121448009458 active site 1121448009459 phosphorylation site [posttranslational modification] 1121448009460 intermolecular recognition site; other site 1121448009461 dimerization interface [polypeptide binding]; other site 1121448009462 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 1121448009463 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 1121448009464 NADP-binding site; other site 1121448009465 homotetramer interface [polypeptide binding]; other site 1121448009466 substrate binding site [chemical binding]; other site 1121448009467 homodimer interface [polypeptide binding]; other site 1121448009468 active site 1121448009469 V-type ATP synthase subunit K; Validated; Region: PRK06649 1121448009470 V-type ATP synthase subunit I; Validated; Region: PRK05771 1121448009471 ATP synthase subunit D; Region: ATP-synt_D; cl00613 1121448009472 V-type ATP synthase subunit B; Provisional; Region: PRK02118 1121448009473 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1121448009474 V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_B; cd01135 1121448009475 Walker A motif homologous position; other site 1121448009476 Walker B motif; other site 1121448009477 V-type ATP synthase subunit A; Provisional; Region: PRK04192 1121448009478 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1121448009479 V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_A; cd01134 1121448009480 Walker A motif/ATP binding site; other site 1121448009481 Walker B motif; other site 1121448009482 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1121448009483 V-type ATP synthase subunit E; Provisional; Region: PRK01558 1121448009484 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1121448009485 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1121448009486 putative dimer interface [polypeptide binding]; other site 1121448009487 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1121448009488 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1121448009489 putative dimer interface [polypeptide binding]; other site 1121448009490 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 1121448009491 Uncharacterized protein family UPF0546; Region: UPF0546; pfam10639 1121448009492 Uncharacterized metal-binding protein [General function prediction only]; Region: COG3894 1121448009493 Mitochondrial small ribosomal subunit Rsm22; Region: Rsm22; cl17847 1121448009494 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 1121448009495 lipoyl synthase; Provisional; Region: PRK05481 1121448009496 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1121448009497 FeS/SAM binding site; other site 1121448009498 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1121448009499 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1121448009500 dimer interface [polypeptide binding]; other site 1121448009501 phosphorylation site [posttranslational modification] 1121448009502 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121448009503 ATP binding site [chemical binding]; other site 1121448009504 Mg2+ binding site [ion binding]; other site 1121448009505 G-X-G motif; other site 1121448009506 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 1121448009507 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1121448009508 substrate binding pocket [chemical binding]; other site 1121448009509 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 1121448009510 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1121448009511 putative binding surface; other site 1121448009512 active site 1121448009513 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 1121448009514 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121448009515 ATP binding site [chemical binding]; other site 1121448009516 Mg2+ binding site [ion binding]; other site 1121448009517 G-X-G motif; other site 1121448009518 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 1121448009519 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 1121448009520 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 1121448009521 putative CheA interaction surface; other site 1121448009522 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1121448009523 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 1121448009524 HAMP domain; Region: HAMP; pfam00672 1121448009525 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1121448009526 dimer interface [polypeptide binding]; other site 1121448009527 putative CheW interface [polypeptide binding]; other site 1121448009528 Superoxide reductase-like (SORL) domain, class II; SORL-domains are present in a family of mononuclear non-heme iron proteins that includes superoxide reductase and desulfoferrodoxin. Superoxide reductase-like proteins scavenge superoxide anion radicals...; Region: SORL_classII; cd03172 1121448009529 non-heme iron binding site [ion binding]; other site 1121448009530 tetramer interface [polypeptide binding]; other site 1121448009531 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 1121448009532 putative CheA interaction surface; other site 1121448009533 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1121448009534 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 1121448009535 HAMP domain; Region: HAMP; pfam00672 1121448009536 dimerization interface [polypeptide binding]; other site 1121448009537 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1121448009538 dimer interface [polypeptide binding]; other site 1121448009539 putative CheW interface [polypeptide binding]; other site 1121448009540 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_7; cd13133 1121448009541 putative efflux protein, MATE family; Region: matE; TIGR00797 1121448009542 Formylmethanofuran dehydrogenase subunit E [Energy production and conversion]; Region: COG2191 1121448009543 FmdE, Molybdenum formylmethanofuran dehydrogenase operon; Region: FmdE; pfam02663 1121448009544 MoeA_like. This domain is similar to a domain found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. There this domain is presumed to bind molybdopterin. The exact function of this subgroup is...; Region: MoeA_like; cd03522 1121448009545 putative MPT binding site; other site 1121448009546 Transcriptional regulator; Region: Rrf2; cl17282 1121448009547 Rrf2 family protein; Region: rrf2_super; TIGR00738 1121448009548 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1121448009549 Ligand Binding Site [chemical binding]; other site 1121448009550 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1121448009551 Transglycosylase SLT domain; Region: SLT_2; pfam13406 1121448009552 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1121448009553 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1121448009554 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1121448009555 murein hydrolase B; Provisional; Region: PRK10760; cl17906 1121448009556 Transglycosylase SLT domain; Region: SLT_2; pfam13406 1121448009557 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1121448009558 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1121448009559 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1121448009560 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1121448009561 PilZ domain; Region: PilZ; pfam07238 1121448009562 zinc-ribbon domain; Region: zinc_ribbon_4; pfam13717 1121448009563 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1121448009564 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1121448009565 P-loop; other site 1121448009566 Magnesium ion binding site [ion binding]; other site 1121448009567 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1121448009568 Magnesium ion binding site [ion binding]; other site 1121448009569 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1121448009570 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 1121448009571 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1121448009572 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1121448009573 P-loop; other site 1121448009574 Magnesium ion binding site [ion binding]; other site 1121448009575 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1121448009576 Magnesium ion binding site [ion binding]; other site 1121448009577 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1121448009578 Nucleoside recognition; Region: Gate; pfam07670 1121448009579 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1121448009580 MltA specific insert domain; Region: MltA; smart00925 1121448009581 3D domain; Region: 3D; pfam06725 1121448009582 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 1121448009583 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 1121448009584 Cache domain; Region: Cache_1; pfam02743 1121448009585 PAS domain; Region: PAS_9; pfam13426 1121448009586 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1121448009587 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1121448009588 dimer interface [polypeptide binding]; other site 1121448009589 putative CheW interface [polypeptide binding]; other site 1121448009590 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 1121448009591 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1121448009592 ATP binding site [chemical binding]; other site 1121448009593 putative Mg++ binding site [ion binding]; other site 1121448009594 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1121448009595 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 1121448009596 nucleotide binding region [chemical binding]; other site 1121448009597 ATP-binding site [chemical binding]; other site 1121448009598 SEC-C motif; Region: SEC-C; pfam02810 1121448009599 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1121448009600 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1121448009601 Cysteine-rich domain; Region: CCG; pfam02754 1121448009602 FAD binding domain; Region: FAD_binding_4; pfam01565 1121448009603 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 1121448009604 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1121448009605 SmpB-tmRNA interface; other site 1121448009606 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 1121448009607 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1121448009608 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1121448009609 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1121448009610 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1121448009611 dimerization domain swap beta strand [polypeptide binding]; other site 1121448009612 regulatory protein interface [polypeptide binding]; other site 1121448009613 active site 1121448009614 regulatory phosphorylation site [posttranslational modification]; other site 1121448009615 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 1121448009616 Predicted methyltransferases [General function prediction only]; Region: COG0313 1121448009617 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 1121448009618 putative SAM binding site [chemical binding]; other site 1121448009619 putative homodimer interface [polypeptide binding]; other site 1121448009620 Uncharacterized protein family UPF0102; Region: UPF0102; cl00516 1121448009621 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1121448009622 RNA/DNA hybrid binding site [nucleotide binding]; other site 1121448009623 active site 1121448009624 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 1121448009625 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1121448009626 SAM-dependent RNA methyltransferase; Region: Methyltrn_RNA_4; cl17853 1121448009627 This domain contains a conserved N-terminal (F/Y)RG motif. It is functionally uncharacterised; Region: FRG; smart00901 1121448009628 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 1121448009629 RimM N-terminal domain; Region: RimM; pfam01782 1121448009630 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 1121448009631 hypothetical protein; Provisional; Region: PRK00468 1121448009632 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 1121448009633 signal recognition particle protein; Provisional; Region: PRK10867 1121448009634 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1121448009635 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1121448009636 P loop; other site 1121448009637 GTP binding site [chemical binding]; other site 1121448009638 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1121448009639 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 1121448009640 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1121448009641 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 1121448009642 Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414 1121448009643 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; smart00790 1121448009644 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 1121448009645 Fic family protein [Function unknown]; Region: COG3177 1121448009646 Fic/DOC family N-terminal; Region: Fic_N; pfam13784 1121448009647 Fic/DOC family; Region: Fic; pfam02661 1121448009648 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1121448009649 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1121448009650 HlyD family secretion protein; Region: HlyD_3; pfam13437 1121448009651 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1121448009652 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1121448009653 Walker A/P-loop; other site 1121448009654 ATP binding site [chemical binding]; other site 1121448009655 Q-loop/lid; other site 1121448009656 ABC transporter signature motif; other site 1121448009657 Walker B; other site 1121448009658 D-loop; other site 1121448009659 H-loop/switch region; other site 1121448009660 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1121448009661 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1121448009662 FtsX-like permease family; Region: FtsX; pfam02687 1121448009663 Repair protein; Region: Repair_PSII; cl01535 1121448009664 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 1121448009665 RNA/DNA hybrid binding site [nucleotide binding]; other site 1121448009666 active site 1121448009667 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1121448009668 Type I periplasmic binding component of ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in uptake of amino acids; Region: PBP1_ABC-type_HAAT_like; cd06333 1121448009669 putative ligand binding site [chemical binding]; other site 1121448009670 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1121448009671 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1121448009672 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1121448009673 TM-ABC transporter signature motif; other site 1121448009674 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1121448009675 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1121448009676 TM-ABC transporter signature motif; other site 1121448009677 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1121448009678 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1121448009679 Walker A/P-loop; other site 1121448009680 ATP binding site [chemical binding]; other site 1121448009681 Q-loop/lid; other site 1121448009682 ABC transporter signature motif; other site 1121448009683 Walker B; other site 1121448009684 D-loop; other site 1121448009685 H-loop/switch region; other site 1121448009686 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1121448009687 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1121448009688 Walker A/P-loop; other site 1121448009689 ATP binding site [chemical binding]; other site 1121448009690 Q-loop/lid; other site 1121448009691 ABC transporter signature motif; other site 1121448009692 Walker B; other site 1121448009693 D-loop; other site 1121448009694 H-loop/switch region; other site 1121448009695 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1121448009696 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 1121448009697 acyl-activating enzyme (AAE) consensus motif; other site 1121448009698 AMP binding site [chemical binding]; other site 1121448009699 active site 1121448009700 CoA binding site [chemical binding]; other site 1121448009701 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1121448009702 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 1121448009703 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 1121448009704 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1121448009705 catalytic loop [active] 1121448009706 iron binding site [ion binding]; other site 1121448009707 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1121448009708 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 1121448009709 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 1121448009710 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1121448009711 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 1121448009712 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 1121448009713 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1121448009714 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1121448009715 Walker A/P-loop; other site 1121448009716 ATP binding site [chemical binding]; other site 1121448009717 Q-loop/lid; other site 1121448009718 ABC transporter signature motif; other site 1121448009719 Walker B; other site 1121448009720 D-loop; other site 1121448009721 H-loop/switch region; other site 1121448009722 cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454 1121448009723 3D domain; Region: 3D; cl01439 1121448009724 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 1121448009725 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 1121448009726 PEGA domain; Region: PEGA; pfam08308 1121448009727 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 1121448009728 PEGA domain; Region: PEGA; pfam08308 1121448009729 PAS domain S-box; Region: sensory_box; TIGR00229 1121448009730 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121448009731 putative active site [active] 1121448009732 heme pocket [chemical binding]; other site 1121448009733 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1121448009734 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1121448009735 metal binding site [ion binding]; metal-binding site 1121448009736 active site 1121448009737 I-site; other site 1121448009738 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1121448009739 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1121448009740 Peptidase family M23; Region: Peptidase_M23; pfam01551 1121448009741 septum site-determining protein MinC; Region: minC; TIGR01222 1121448009742 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 1121448009743 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 1121448009744 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 1121448009745 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 1121448009746 Switch I; other site 1121448009747 Switch II; other site 1121448009748 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 1121448009749 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp2; TIGR03088 1121448009750 This family is most closely related to the GT1 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis; Region: GT1_WbnK_like; cd03807 1121448009751 putative ADP-binding pocket [chemical binding]; other site 1121448009752 threonine synthase; Validated; Region: PRK06260 1121448009753 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 1121448009754 homodimer interface [polypeptide binding]; other site 1121448009755 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1121448009756 catalytic residue [active] 1121448009757 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 1121448009758 Protein of unknown function (DUF1778); Region: DUF1778; cl01845 1121448009759 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 1121448009760 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1121448009761 salt bridge; other site 1121448009762 non-specific DNA binding site [nucleotide binding]; other site 1121448009763 sequence-specific DNA binding site [nucleotide binding]; other site 1121448009764 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1121448009765 PAS domain S-box; Region: sensory_box; TIGR00229 1121448009766 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121448009767 putative active site [active] 1121448009768 heme pocket [chemical binding]; other site 1121448009769 PAS domain S-box; Region: sensory_box; TIGR00229 1121448009770 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121448009771 putative active site [active] 1121448009772 heme pocket [chemical binding]; other site 1121448009773 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1121448009774 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1121448009775 dimer interface [polypeptide binding]; other site 1121448009776 phosphorylation site [posttranslational modification] 1121448009777 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121448009778 ATP binding site [chemical binding]; other site 1121448009779 Mg2+ binding site [ion binding]; other site 1121448009780 G-X-G motif; other site 1121448009781 Response regulator receiver domain; Region: Response_reg; pfam00072 1121448009782 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121448009783 active site 1121448009784 phosphorylation site [posttranslational modification] 1121448009785 intermolecular recognition site; other site 1121448009786 dimerization interface [polypeptide binding]; other site 1121448009787 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1121448009788 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 1121448009789 active site 1121448009790 TDP-binding site; other site 1121448009791 acceptor substrate-binding pocket; other site 1121448009792 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1121448009793 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1121448009794 dimer interface [polypeptide binding]; other site 1121448009795 phosphorylation site [posttranslational modification] 1121448009796 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121448009797 ATP binding site [chemical binding]; other site 1121448009798 Mg2+ binding site [ion binding]; other site 1121448009799 G-X-G motif; other site 1121448009800 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1121448009801 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121448009802 active site 1121448009803 phosphorylation site [posttranslational modification] 1121448009804 intermolecular recognition site; other site 1121448009805 dimerization interface [polypeptide binding]; other site 1121448009806 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1121448009807 DNA binding site [nucleotide binding] 1121448009808 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 1121448009809 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1121448009810 metal ion-dependent adhesion site (MIDAS); other site 1121448009811 NAD-dependent deacetylase; Provisional; Region: PRK00481 1121448009812 SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2-fam; cd01407 1121448009813 NAD+ binding site [chemical binding]; other site 1121448009814 substrate binding site [chemical binding]; other site 1121448009815 Zn binding site [ion binding]; other site 1121448009816 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 1121448009817 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1121448009818 TolR protein; Region: tolR; TIGR02801 1121448009819 TonB C terminal; Region: TonB_2; pfam13103 1121448009820 TonB C terminal; Region: TonB_2; pfam13103 1121448009821 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 1121448009822 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1121448009823 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1121448009824 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1121448009825 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1121448009826 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1121448009827 ligand binding site [chemical binding]; other site 1121448009828 nickel responsive regulator; Provisional; Region: PRK04460 1121448009829 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 1121448009830 NikR C terminal nickel binding domain; Region: NikR_C; pfam08753 1121448009831 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 1121448009832 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 1121448009833 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 1121448009834 Uncharacterized conserved protein [Function unknown]; Region: COG3937 1121448009835 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 1121448009836 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 1121448009837 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1121448009838 Radical SAM superfamily; Region: Radical_SAM; pfam04055 1121448009839 FeS/SAM binding site; other site 1121448009840 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 1121448009841 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1121448009842 dimerization interface [polypeptide binding]; other site 1121448009843 putative ATP binding site [chemical binding]; other site 1121448009844 AmmeMemoRadiSam system radical SAM enzyme; Region: AmmeMemoSam_rS; TIGR04337 1121448009845 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1121448009846 FeS/SAM binding site; other site 1121448009847 Nitrogen fixation protein of unknown function; Region: Nif11; pfam07862 1121448009848 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; Region: CobA_CobO_BtuR; pfam02572 1121448009849 AAA domain; Region: AAA_22; pfam13401 1121448009850 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1121448009851 Walker A/P-loop; other site 1121448009852 ATP binding site [chemical binding]; other site 1121448009853 ABC transporter; Region: ABC_tran; pfam00005 1121448009854 Q-loop/lid; other site 1121448009855 ABC transporter signature motif; other site 1121448009856 Walker B; other site 1121448009857 D-loop; other site 1121448009858 H-loop/switch region; other site 1121448009859 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1121448009860 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1121448009861 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1121448009862 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1121448009863 dimer interface [polypeptide binding]; other site 1121448009864 conserved gate region; other site 1121448009865 putative PBP binding loops; other site 1121448009866 ABC-ATPase subunit interface; other site 1121448009867 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1121448009868 dimerization interface [polypeptide binding]; other site 1121448009869 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1121448009870 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1121448009871 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121448009872 PAS fold; Region: PAS_3; pfam08447 1121448009873 putative active site [active] 1121448009874 heme pocket [chemical binding]; other site 1121448009875 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1121448009876 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1121448009877 dimer interface [polypeptide binding]; other site 1121448009878 phosphorylation site [posttranslational modification] 1121448009879 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121448009880 ATP binding site [chemical binding]; other site 1121448009881 Mg2+ binding site [ion binding]; other site 1121448009882 G-X-G motif; other site 1121448009883 cobyric acid synthase; Provisional; Region: PRK00784 1121448009884 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 1121448009885 catalytic triad [active] 1121448009886 GrpE; Region: GrpE; pfam01025 1121448009887 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1121448009888 dimer interface [polypeptide binding]; other site 1121448009889 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1121448009890 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1121448009891 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 1121448009892 nucleotide binding site [chemical binding]; other site 1121448009893 NEF interaction site [polypeptide binding]; other site 1121448009894 SBD interface [polypeptide binding]; other site 1121448009895 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1121448009896 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1121448009897 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 1121448009898 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1121448009899 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 1121448009900 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 1121448009901 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1121448009902 Ligand Binding Site [chemical binding]; other site 1121448009903 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1121448009904 MiaB-like tRNA modifying enzyme; Region: MiaB-like-C; TIGR01579 1121448009905 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1121448009906 FeS/SAM binding site; other site 1121448009907 hypothetical protein; Provisional; Region: PRK11820 1121448009908 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 1121448009909 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 1121448009910 hypothetical protein; Provisional; Region: PRK04323 1121448009911 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1121448009912 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1121448009913 catalytic site [active] 1121448009914 G-X2-G-X-G-K; other site 1121448009915 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1121448009916 active site 1121448009917 dimer interface [polypeptide binding]; other site 1121448009918 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 1121448009919 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1121448009920 TPR motif; other site 1121448009921 binding surface 1121448009922 HDOD domain; Region: HDOD; pfam08668 1121448009923 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1121448009924 Zn2+ binding site [ion binding]; other site 1121448009925 Mg2+ binding site [ion binding]; other site 1121448009926 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 1121448009927 DHH family; Region: DHH; pfam01368 1121448009928 DHHA1 domain; Region: DHHA1; pfam02272 1121448009929 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1121448009930 anti sigma factor interaction site; other site 1121448009931 regulatory phosphorylation site [posttranslational modification]; other site 1121448009932 N-terminal Early set domain associated with the catalytic domain of isoamylase-like (also called glycogen 6-glucanohydrolase) proteins; Region: E_set_Isoamylase_like_N; cd07184 1121448009933 Helix-turn-helix domain; Region: HTH_17; pfam12728 1121448009934 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1121448009935 PAS domain; Region: PAS_8; pfam13188 1121448009936 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121448009937 ATP binding site [chemical binding]; other site 1121448009938 Mg2+ binding site [ion binding]; other site 1121448009939 G-X-G motif; other site 1121448009940 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 1121448009941 substrate binding pocket [chemical binding]; other site 1121448009942 membrane-bound complex binding site; other site 1121448009943 hinge residues; other site 1121448009944 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cd00596 1121448009945 active site 1121448009946 Zn binding site [ion binding]; other site 1121448009947 Plasmid maintenance system killer protein [General function prediction only]; Region: HigB; COG3549 1121448009948 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 1121448009949 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1121448009950 sequence-specific DNA binding site [nucleotide binding]; other site 1121448009951 salt bridge; other site 1121448009952 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 1121448009953 intermolecular recognition site; other site 1121448009954 active site 1121448009955 dimerization interface [polypeptide binding]; other site 1121448009956 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1121448009957 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1121448009958 Walker A motif; other site 1121448009959 ATP binding site [chemical binding]; other site 1121448009960 Walker B motif; other site 1121448009961 arginine finger; other site 1121448009962 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 1121448009963 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1121448009964 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1121448009965 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 1121448009966 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1121448009967 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 1121448009968 RsbT co-antagonist protein rsbRD N-terminal domain; Region: RsbRD_N; pfam14361 1121448009969 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 1121448009970 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1121448009971 dimer interface [polypeptide binding]; other site 1121448009972 putative CheW interface [polypeptide binding]; other site 1121448009973 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 1121448009974 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1121448009975 putative binding surface; other site 1121448009976 active site 1121448009977 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 1121448009978 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121448009979 ATP binding site [chemical binding]; other site 1121448009980 Mg2+ binding site [ion binding]; other site 1121448009981 G-X-G motif; other site 1121448009982 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 1121448009983 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1121448009984 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121448009985 active site 1121448009986 phosphorylation site [posttranslational modification] 1121448009987 intermolecular recognition site; other site 1121448009988 dimerization interface [polypeptide binding]; other site 1121448009989 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 1121448009990 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588 1121448009991 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588 1121448009992 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 1121448009993 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 1121448009994 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1121448009995 putative binding surface; other site 1121448009996 active site 1121448009997 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1121448009998 putative binding surface; other site 1121448009999 active site 1121448010000 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 1121448010001 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121448010002 ATP binding site [chemical binding]; other site 1121448010003 Mg2+ binding site [ion binding]; other site 1121448010004 G-X-G motif; other site 1121448010005 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 1121448010006 Response regulator receiver domain; Region: Response_reg; pfam00072 1121448010007 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121448010008 active site 1121448010009 phosphorylation site [posttranslational modification] 1121448010010 intermolecular recognition site; other site 1121448010011 dimerization interface [polypeptide binding]; other site 1121448010012 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 1121448010013 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 1121448010014 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1121448010015 S-adenosylmethionine binding site [chemical binding]; other site 1121448010016 HEAT repeats; Region: HEAT_2; pfam13646 1121448010017 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 1121448010018 HEAT repeats; Region: HEAT_2; pfam13646 1121448010019 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 1121448010020 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121448010021 active site 1121448010022 phosphorylation site [posttranslational modification] 1121448010023 intermolecular recognition site; other site 1121448010024 dimerization interface [polypeptide binding]; other site 1121448010025 CheB methylesterase; Region: CheB_methylest; pfam01339 1121448010026 CheD chemotactic sensory transduction; Region: CheD; cl00810 1121448010027 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 1121448010028 putative CheA interaction surface; other site 1121448010029 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 1121448010030 putative CheA interaction surface; other site 1121448010031 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 1121448010032 putative CheA interaction surface; other site 1121448010033 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1121448010034 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1121448010035 dimer interface [polypeptide binding]; other site 1121448010036 putative CheW interface [polypeptide binding]; other site 1121448010037 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1121448010038 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1121448010039 dimer interface [polypeptide binding]; other site 1121448010040 putative CheW interface [polypeptide binding]; other site 1121448010041 Response regulator receiver domain; Region: Response_reg; pfam00072 1121448010042 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121448010043 active site 1121448010044 phosphorylation site [posttranslational modification] 1121448010045 intermolecular recognition site; other site 1121448010046 dimerization interface [polypeptide binding]; other site 1121448010047 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1121448010048 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 1121448010049 PilZ domain; Region: PilZ; pfam07238 1121448010050 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1121448010051 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1121448010052 Walker A/P-loop; other site 1121448010053 ATP binding site [chemical binding]; other site 1121448010054 Q-loop/lid; other site 1121448010055 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1121448010056 ABC transporter signature motif; other site 1121448010057 Walker B; other site 1121448010058 D-loop; other site 1121448010059 ABC transporter; Region: ABC_tran_2; pfam12848 1121448010060 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1121448010061 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 1121448010062 tartrate dehydrogenase; Region: TTC; TIGR02089 1121448010063 3-isopropylmalate dehydratase small subunit; Reviewed; Region: leuD; PRK00439 1121448010064 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1121448010065 substrate binding site [chemical binding]; other site 1121448010066 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1121448010067 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 1121448010068 substrate binding site [chemical binding]; other site 1121448010069 ligand binding site [chemical binding]; other site 1121448010070 2-isopropylmalate synthase; Validated; Region: PRK00915 1121448010071 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 1121448010072 active site 1121448010073 catalytic residues [active] 1121448010074 metal binding site [ion binding]; metal-binding site 1121448010075 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 1121448010076 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 1121448010077 active site 1121448010078 phosphorylation site [posttranslational modification] 1121448010079 intermolecular recognition site; other site 1121448010080 dimerization interface [polypeptide binding]; other site 1121448010081 Response regulator receiver domain; Region: Response_reg; pfam00072 1121448010082 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121448010083 active site 1121448010084 phosphorylation site [posttranslational modification] 1121448010085 intermolecular recognition site; other site 1121448010086 dimerization interface [polypeptide binding]; other site 1121448010087 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1121448010088 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1121448010089 metal binding site [ion binding]; metal-binding site 1121448010090 active site 1121448010091 I-site; other site 1121448010092 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 1121448010093 ?-D-glucose-1-phosphatase; Provisional; Region: PRK09456 1121448010094 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1121448010095 IHF - DNA interface [nucleotide binding]; other site 1121448010096 IHF dimer interface [polypeptide binding]; other site 1121448010097 CheD chemotactic sensory transduction; Region: CheD; cl00810 1121448010098 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1121448010099 TPR motif; other site 1121448010100 binding surface 1121448010101 TPR repeat; Region: TPR_11; pfam13414 1121448010102 TPR repeat; Region: TPR_11; pfam13414 1121448010103 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1121448010104 TPR motif; other site 1121448010105 binding surface 1121448010106 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 1121448010107 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 1121448010108 putative NAD(P) binding site [chemical binding]; other site 1121448010109 putative active site [active] 1121448010110 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121448010111 Response regulator receiver domain; Region: Response_reg; pfam00072 1121448010112 active site 1121448010113 phosphorylation site [posttranslational modification] 1121448010114 intermolecular recognition site; other site 1121448010115 dimerization interface [polypeptide binding]; other site 1121448010116 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1121448010117 PAS domain; Region: PAS_9; pfam13426 1121448010118 putative active site [active] 1121448010119 heme pocket [chemical binding]; other site 1121448010120 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1121448010121 Zn2+ binding site [ion binding]; other site 1121448010122 Mg2+ binding site [ion binding]; other site 1121448010123 NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061 1121448010124 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03708 1121448010125 Protein of unknown function DUF89; Region: DUF89; cl15397 1121448010126 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 1121448010127 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1121448010128 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1121448010129 dimer interface [polypeptide binding]; other site 1121448010130 phosphorylation site [posttranslational modification] 1121448010131 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121448010132 ATP binding site [chemical binding]; other site 1121448010133 Mg2+ binding site [ion binding]; other site 1121448010134 G-X-G motif; other site 1121448010135 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1121448010136 Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400 1121448010137 putative active site [active] 1121448010138 putative metal binding site [ion binding]; other site 1121448010139 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1121448010140 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121448010141 active site 1121448010142 phosphorylation site [posttranslational modification] 1121448010143 intermolecular recognition site; other site 1121448010144 dimerization interface [polypeptide binding]; other site 1121448010145 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1121448010146 TPR motif; other site 1121448010147 binding surface 1121448010148 TPR repeat; Region: TPR_11; pfam13414 1121448010149 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1121448010150 binding surface 1121448010151 TPR motif; other site 1121448010152 TPR repeat; Region: TPR_11; pfam13414 1121448010153 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 1121448010154 shikimate kinase; Reviewed; Region: aroK; PRK00131 1121448010155 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1121448010156 ADP binding site [chemical binding]; other site 1121448010157 magnesium binding site [ion binding]; other site 1121448010158 putative shikimate binding site; other site 1121448010159 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 1121448010160 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1121448010161 23S rRNA interface [nucleotide binding]; other site 1121448010162 L3 interface [polypeptide binding]; other site 1121448010163 HD domain; Region: HD_3; pfam13023 1121448010164 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 1121448010165 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1121448010166 Walker A/P-loop; other site 1121448010167 ATP binding site [chemical binding]; other site 1121448010168 Q-loop/lid; other site 1121448010169 ABC transporter signature motif; other site 1121448010170 Walker B; other site 1121448010171 D-loop; other site 1121448010172 H-loop/switch region; other site 1121448010173 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1121448010174 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 1121448010175 TM-ABC transporter signature motif; other site 1121448010176 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 1121448010177 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1121448010178 zinc binding site [ion binding]; other site 1121448010179 putative ligand binding site [chemical binding]; other site 1121448010180 Flagellar protein YcgR; Region: YcgR_2; pfam12945 1121448010181 PilZ domain; Region: PilZ; pfam07238 1121448010182 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 1121448010183 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1121448010184 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1121448010185 catalytic residue [active] 1121448010186 integrase; Provisional; Region: PRK09692 1121448010187 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 1121448010188 active site 1121448010189 Int/Topo IB signature motif; other site 1121448010190 Helix-turn-helix domain; Region: HTH_17; pfam12728 1121448010191 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 1121448010192 active site 1121448010193 metal binding site [ion binding]; metal-binding site 1121448010194 interdomain interaction site; other site 1121448010195 Protein of unknown function (DUF3987); Region: DUF3987; pfam13148 1121448010196 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 1121448010197 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1121448010198 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1121448010199 non-specific DNA binding site [nucleotide binding]; other site 1121448010200 salt bridge; other site 1121448010201 sequence-specific DNA binding site [nucleotide binding]; other site 1121448010202 Domain of unknown function (DUF4160); Region: DUF4160; pfam13711 1121448010203 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 1121448010204 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 1121448010205 YcfA-like protein; Region: YcfA; cl00752 1121448010206 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 1121448010207 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1121448010208 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 1121448010209 Winged helix-turn helix; Region: HTH_29; pfam13551 1121448010210 Homeodomain-like domain; Region: HTH_23; cl17451 1121448010211 Homeodomain-like domain; Region: HTH_32; pfam13565 1121448010212 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1121448010213 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1121448010214 Walker A motif; other site 1121448010215 ATP binding site [chemical binding]; other site 1121448010216 Walker B motif; other site 1121448010217 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1121448010218 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1121448010219 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1121448010220 catalytic residue [active] 1121448010221 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 1121448010222 putative trimer interface [polypeptide binding]; other site 1121448010223 putative CoA binding site [chemical binding]; other site 1121448010224 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 1121448010225 WbqC-like protein family; Region: WbqC; pfam08889 1121448010226 Glycosyl transferase family 2; Region: Glyco_tranf_2_4; pfam13704 1121448010227 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 1121448010228 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 1121448010229 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1121448010230 FeS/SAM binding site; other site 1121448010231 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 1121448010232 benzoyl-CoA reductase, subunit C; Region: benz_CoA_red_C; TIGR02263 1121448010233 benzoyl-CoA reductase, bcr type, subunit B; Region: benz_CoA_red_B; TIGR02260 1121448010234 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 1121448010235 Protein of unknown function (DUF3798); Region: DUF3798; pfam12683 1121448010236 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1121448010237 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1121448010238 Walker A/P-loop; other site 1121448010239 ATP binding site [chemical binding]; other site 1121448010240 Q-loop/lid; other site 1121448010241 ABC transporter signature motif; other site 1121448010242 Walker B; other site 1121448010243 D-loop; other site 1121448010244 H-loop/switch region; other site 1121448010245 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1121448010246 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 1121448010247 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1121448010248 TM-ABC transporter signature motif; other site 1121448010249 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 1121448010250 TM-ABC transporter signature motif; other site 1121448010251 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 1121448010252 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 1121448010253 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; cl17549 1121448010254 formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553 1121448010255 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1121448010256 molybdopterin cofactor binding site; other site 1121448010257 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1121448010258 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1121448010259 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 1121448010260 molybdopterin cofactor binding site; other site 1121448010261 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 1121448010262 formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562 1121448010263 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1121448010264 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1121448010265 catalytic residues [active] 1121448010266 catalytic nucleophile [active] 1121448010267 Presynaptic Site I dimer interface [polypeptide binding]; other site 1121448010268 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1121448010269 Synaptic Flat tetramer interface [polypeptide binding]; other site 1121448010270 Synaptic Site I dimer interface [polypeptide binding]; other site 1121448010271 DNA binding site [nucleotide binding] 1121448010272 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1121448010273 DNA-binding interface [nucleotide binding]; DNA binding site 1121448010274 HipA N-terminal domain; Region: couple_hipA; TIGR03071 1121448010275 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 1121448010276 HipA-like N-terminal domain; Region: HipA_N; pfam07805 1121448010277 HipA-like C-terminal domain; Region: HipA_C; pfam07804 1121448010278 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1121448010279 sequence-specific DNA binding site [nucleotide binding]; other site 1121448010280 salt bridge; other site 1121448010281 DNA binding domain, excisionase family; Region: excise; TIGR01764 1121448010282 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1121448010283 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1121448010284 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1121448010285 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 1121448010286 active site 1121448010287 NTP binding site [chemical binding]; other site 1121448010288 metal binding triad [ion binding]; metal-binding site 1121448010289 antibiotic binding site [chemical binding]; other site 1121448010290 Uncharacterized conserved protein [Function unknown]; Region: COG2361 1121448010291 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1121448010292 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 1121448010293 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 1121448010294 DNA-binding interface [nucleotide binding]; DNA binding site 1121448010295 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121448010296 PAS domain; Region: PAS_9; pfam13426 1121448010297 putative active site [active] 1121448010298 heme pocket [chemical binding]; other site 1121448010299 PAS domain S-box; Region: sensory_box; TIGR00229 1121448010300 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121448010301 putative active site [active] 1121448010302 heme pocket [chemical binding]; other site 1121448010303 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1121448010304 His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388 1121448010305 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121448010306 ATP binding site [chemical binding]; other site 1121448010307 Mg2+ binding site [ion binding]; other site 1121448010308 G-X-G motif; other site 1121448010309 CheB methylesterase; Region: CheB_methylest; pfam01339 1121448010310 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 1121448010311 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 1121448010312 TATA element modulatory factor 1 TATA binding; Region: TMF_TATA_bd; pfam12325 1121448010313 PAS domain; Region: PAS_10; pfam13596 1121448010314 Sp18 and Lysin from Archaegastropoda (marine mollusks of the families Halotidae and Trochidae) sperm. Both proteins play an important role in fertilization: sp18 mediates fusion between sperm and egg cell membrane, lysin dissolves the vitelline envelope...; Region: Lysin-Sp18; cl11599 1121448010315 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1121448010316 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121448010317 active site 1121448010318 phosphorylation site [posttranslational modification] 1121448010319 intermolecular recognition site; other site 1121448010320 dimerization interface [polypeptide binding]; other site 1121448010321 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1121448010322 Walker A motif; other site 1121448010323 ATP binding site [chemical binding]; other site 1121448010324 Walker B motif; other site 1121448010325 arginine finger; other site 1121448010326 BON domain; Region: BON; pfam04972 1121448010327 BON domain; Region: BON; pfam04972 1121448010328 Protein of unknown function (DUF3309); Region: DUF3309; pfam11752 1121448010329 CsbD-like; Region: CsbD; pfam05532 1121448010330 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1121448010331 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1121448010332 Putative glucoamylase; Region: Glycoamylase; pfam10091 1121448010333 Second GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_2_like; cd11753 1121448010334 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 1121448010335 First GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_1_like; cd11756 1121448010336 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 1121448010337 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1121448010338 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1121448010339 patatin-related protein; Region: TIGR03607 1121448010340 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria and archaea; Region: GIY-YIG_unchar_2; cd10447 1121448010341 GIY-YIG motif/motif A; other site 1121448010342 putative active site [active] 1121448010343 putative metal binding site [ion binding]; other site 1121448010344 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1121448010345 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 1121448010346 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1121448010347 Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077 1121448010348 DsrE/DsrF-like family; Region: DrsE; pfam02635 1121448010349 integrase; Provisional; Region: int; PHA02601 1121448010350 Phage integrase family; Region: Phage_integrase; pfam00589 1121448010351 active site 1121448010352 DNA binding site [nucleotide binding] 1121448010353 Int/Topo IB signature motif; other site 1121448010354 Helix-turn-helix domain; Region: HTH_17; cl17695 1121448010355 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1121448010356 active site 1121448010357 DNA binding site [nucleotide binding] 1121448010358 Int/Topo IB signature motif; other site 1121448010359 transcription termination factor Rho; Provisional; Region: rho; PRK09376 1121448010360 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 1121448010361 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 1121448010362 RNA binding site [nucleotide binding]; other site 1121448010363 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 1121448010364 multimer interface [polypeptide binding]; other site 1121448010365 Walker A motif; other site 1121448010366 ATP binding site [chemical binding]; other site 1121448010367 Walker B motif; other site 1121448010368 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 1121448010369 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1121448010370 putative active site [active] 1121448010371 catalytic residue [active] 1121448010372 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 1121448010373 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 1121448010374 5S rRNA interface [nucleotide binding]; other site 1121448010375 CTC domain interface [polypeptide binding]; other site 1121448010376 L16 interface [polypeptide binding]; other site 1121448010377 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 1121448010378 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1121448010379 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1121448010380 active site 1121448010381 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14615 1121448010382 ATP-dependent protease subunit HslV; Provisional; Region: PRK05456 1121448010383 active site 1121448010384 Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cl00019 1121448010385 ADP-ribose binding site [chemical binding]; other site 1121448010386 Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378 1121448010387 trimer interface [polypeptide binding]; other site 1121448010388 putative Zn binding site [ion binding]; other site 1121448010389 Peptidase family M48; Region: Peptidase_M48; pfam01435 1121448010390 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1121448010391 binding surface 1121448010392 TPR motif; other site 1121448010393 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1121448010394 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1121448010395 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1121448010396 active site 1121448010397 HIGH motif; other site 1121448010398 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1121448010399 KMSKS motif; other site 1121448010400 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1121448010401 tRNA binding surface [nucleotide binding]; other site 1121448010402 anticodon binding site; other site 1121448010403 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 1121448010404 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 1121448010405 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 1121448010406 metal binding triad [ion binding]; metal-binding site 1121448010407 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 1121448010408 pyruvate carboxylase; Reviewed; Region: PRK12999 1121448010409 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1121448010410 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1121448010411 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1121448010412 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 1121448010413 active site 1121448010414 catalytic residues [active] 1121448010415 metal binding site [ion binding]; metal-binding site 1121448010416 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1121448010417 carboxyltransferase (CT) interaction site; other site 1121448010418 biotinylation site [posttranslational modification]; other site 1121448010419 flagellin; Provisional; Region: PRK12802 1121448010420 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1121448010421 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1121448010422 flagellar capping protein; Provisional; Region: PRK12765 1121448010423 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 1121448010424 Flagellin hook IN motif; Region: Flagellin_IN; pfam07196 1121448010425 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 1121448010426 Flagellin-specific chaperone FliS [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliS; COG1516 1121448010427 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1121448010428 RIP metalloprotease RseP; Region: TIGR00054 1121448010429 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1121448010430 active site 1121448010431 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1121448010432 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1121448010433 putative substrate binding region [chemical binding]; other site 1121448010434 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 1121448010435 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 1121448010436 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 1121448010437 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 1121448010438 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 1121448010439 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1121448010440 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 1121448010441 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 1121448010442 catalytic residue [active] 1121448010443 putative FPP diphosphate binding site; other site 1121448010444 putative FPP binding hydrophobic cleft; other site 1121448010445 dimer interface [polypeptide binding]; other site 1121448010446 putative IPP diphosphate binding site; other site 1121448010447 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1121448010448 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1121448010449 hinge region; other site 1121448010450 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1121448010451 putative nucleotide binding site [chemical binding]; other site 1121448010452 uridine monophosphate binding site [chemical binding]; other site 1121448010453 homohexameric interface [polypeptide binding]; other site 1121448010454 elongation factor Ts; Provisional; Region: tsf; PRK09377 1121448010455 UBA/TS-N domain; Region: UBA; pfam00627 1121448010456 Elongation factor TS; Region: EF_TS; pfam00889 1121448010457 Elongation factor TS; Region: EF_TS; pfam00889 1121448010458 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1121448010459 rRNA interaction site [nucleotide binding]; other site 1121448010460 S8 interaction site; other site 1121448010461 putative laminin-1 binding site; other site 1121448010462 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 1121448010463 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1121448010464 FMN binding site [chemical binding]; other site 1121448010465 substrate binding site [chemical binding]; other site 1121448010466 putative catalytic residue [active] 1121448010467 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 1121448010468 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 1121448010469 active site 1121448010470 substrate binding site [chemical binding]; other site 1121448010471 metal binding site [ion binding]; metal-binding site 1121448010472 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1121448010473 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1121448010474 active site 1121448010475 ATP binding site [chemical binding]; other site 1121448010476 substrate binding site [chemical binding]; other site 1121448010477 activation loop (A-loop); other site 1121448010478 AAA ATPase domain; Region: AAA_16; pfam13191 1121448010479 Predicted ATPase [General function prediction only]; Region: COG3899 1121448010480 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1121448010481 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1121448010482 PAS domain S-box; Region: sensory_box; TIGR00229 1121448010483 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1121448010484 putative active site [active] 1121448010485 heme pocket [chemical binding]; other site 1121448010486 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1121448010487 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1121448010488 metal binding site [ion binding]; metal-binding site 1121448010489 active site 1121448010490 I-site; other site 1121448010491 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 1121448010492 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 1121448010493 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1121448010494 dimerization interface [polypeptide binding]; other site 1121448010495 PAS fold; Region: PAS_4; pfam08448 1121448010496 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1121448010497 putative active site [active] 1121448010498 heme pocket [chemical binding]; other site 1121448010499 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1121448010500 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1121448010501 dimer interface [polypeptide binding]; other site 1121448010502 putative CheW interface [polypeptide binding]; other site 1121448010503 Response regulator receiver domain; Region: Response_reg; pfam00072 1121448010504 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121448010505 active site 1121448010506 phosphorylation site [posttranslational modification] 1121448010507 intermolecular recognition site; other site 1121448010508 dimerization interface [polypeptide binding]; other site 1121448010509 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1121448010510 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 1121448010511 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 1121448010512 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1121448010513 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1121448010514 catalytic residue [active] 1121448010515 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1121448010516 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1121448010517 FtsX-like permease family; Region: FtsX; pfam02687 1121448010518 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1121448010519 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1121448010520 Walker A/P-loop; other site 1121448010521 ATP binding site [chemical binding]; other site 1121448010522 Q-loop/lid; other site 1121448010523 ABC transporter signature motif; other site 1121448010524 Walker B; other site 1121448010525 D-loop; other site 1121448010526 H-loop/switch region; other site 1121448010527 Outer membrane efflux protein; Region: OEP; pfam02321 1121448010528 Outer membrane efflux protein; Region: OEP; pfam02321 1121448010529 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1121448010530 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 1121448010531 HlyD family secretion protein; Region: HlyD_3; pfam13437 1121448010532 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1121448010533 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 1121448010534 Ligand binding site; other site 1121448010535 Putative Catalytic site; other site 1121448010536 DXD motif; other site 1121448010537 Protein of unknown function (DUF342); Region: DUF342; pfam03961 1121448010538 TPR repeat; Region: TPR_11; pfam13414 1121448010539 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1121448010540 binding surface 1121448010541 TPR motif; other site 1121448010542 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1121448010543 TPR motif; other site 1121448010544 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1121448010545 binding surface 1121448010546 purine nucleoside phosphorylase; Provisional; Region: PRK08202 1121448010547 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 1121448010548 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 1121448010549 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 1121448010550 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1121448010551 ligand binding site [chemical binding]; other site 1121448010552 PilZ domain; Region: PilZ; pfam07238 1121448010553 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1121448010554 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1121448010555 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1121448010556 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1121448010557 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1121448010558 Acetyl-CoA carboxylase beta subunit [Lipid metabolism]; Region: AccD; COG0777 1121448010559 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1121448010560 chromosomal replication initiation protein; Provisional; Region: PRK12422 1121448010561 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1121448010562 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1121448010563 dimer interface [polypeptide binding]; other site 1121448010564 ssDNA binding site [nucleotide binding]; other site 1121448010565 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1121448010566 putative metalloenzyme radical SAM/SPASM domain maturase; Region: rSAM_Geo_metal; TIGR04311 1121448010567 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1121448010568 FeS/SAM binding site; other site 1121448010569 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 1121448010570 active site 1121448010571 putative DNA-binding cleft [nucleotide binding]; other site 1121448010572 dimer interface [polypeptide binding]; other site 1121448010573 Holliday junction DNA helicase RuvA; Provisional; Region: ruvA; PRK14602 1121448010574 RuvA N terminal domain; Region: RuvA_N; pfam01330 1121448010575 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 1121448010576 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1121448010577 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1121448010578 Walker A motif; other site 1121448010579 ATP binding site [chemical binding]; other site 1121448010580 Walker B motif; other site 1121448010581 arginine finger; other site 1121448010582 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1121448010583 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 1121448010584 DnaA N-terminal domain; Region: DnaA_N; pfam11638 1121448010585 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 1121448010586 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1121448010587 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1121448010588 Walker A motif; other site 1121448010589 ATP binding site [chemical binding]; other site 1121448010590 Walker B motif; other site 1121448010591 arginine finger; other site 1121448010592 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1121448010593 DnaA box-binding interface [nucleotide binding]; other site 1121448010594 hypothetical protein; Provisional; Region: PRK04334 1121448010595 LPP20 lipoprotein; Region: LPP20; pfam02169 1121448010596 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 1121448010597 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 1121448010598 putative active site [active] 1121448010599 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 1121448010600 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1121448010601 TPR motif; other site 1121448010602 binding surface 1121448010603 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1121448010604 TPR motif; other site 1121448010605 binding surface 1121448010606 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1121448010607 binding surface 1121448010608 TPR motif; other site 1121448010609 TPR repeat; Region: TPR_11; pfam13414 1121448010610 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1121448010611 alternative sigma factor RpoH; Region: rpoH_proteo; TIGR02392 1121448010612 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1121448010613 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1121448010614 DNA binding residues [nucleotide binding] 1121448010615 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 1121448010616 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 1121448010617 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 1121448010618 substrate binding pocket [chemical binding]; other site 1121448010619 dihydropteroate synthase; Region: DHPS; TIGR01496 1121448010620 dimer interface [polypeptide binding]; other site 1121448010621 inhibitor binding site; inhibition site 1121448010622 B12 binding domain of corrinoid proteins. A family of small methanogenic corrinoid proteins that bind methyl-Co(III) 5-hydroxybenzimidazolylcobamide as a cofactor. They play a role on the methanogenesis from trimethylamine, dimethylamine or...; Region: corrinoid_protein_B12-BD; cd02070 1121448010623 methyltransferase cognate corrinoid proteins, Methanosarcina family; Region: pyl_corrinoid; TIGR02370 1121448010624 B12 binding site [chemical binding]; other site 1121448010625 cobalt ligand [ion binding]; other site 1121448010626 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1121448010627 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1121448010628 catalytic residues [active] 1121448010629 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1121448010630 Coenzyme A binding pocket [chemical binding]; other site 1121448010631 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1121448010632 active site 1121448010633 zinc-ribbon domain; Region: zinc_ribbon_4; pfam13717 1121448010634 Protein of unknown function (DUF3426); Region: DUF3426; pfam11906 1121448010635 DNA repair protein RadA; Provisional; Region: PRK11823 1121448010636 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1121448010637 Walker A motif; other site 1121448010638 ATP binding site [chemical binding]; other site 1121448010639 Walker B motif; other site 1121448010640 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1121448010641 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1121448010642 dimer interface [polypeptide binding]; other site 1121448010643 putative CheW interface [polypeptide binding]; other site 1121448010644 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1121448010645 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121448010646 active site 1121448010647 phosphorylation site [posttranslational modification] 1121448010648 intermolecular recognition site; other site 1121448010649 dimerization interface [polypeptide binding]; other site 1121448010650 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1121448010651 putative binding surface; other site 1121448010652 active site 1121448010653 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 1121448010654 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 1121448010655 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1121448010656 ATP binding site [chemical binding]; other site 1121448010657 Mg2+ binding site [ion binding]; other site 1121448010658 G-X-G motif; other site 1121448010659 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 1121448010660 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 1121448010661 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 1121448010662 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 1121448010663 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 1121448010664 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1121448010665 active site 1121448010666 phosphorylation site [posttranslational modification] 1121448010667 intermolecular recognition site; other site 1121448010668 dimerization interface [polypeptide binding]; other site 1121448010669 CheB methylesterase; Region: CheB_methylest; pfam01339 1121448010670 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 1121448010671 Adenylyl cyclase (AC) class IV-like, a subgroup of the CYTH-like superfamily; Region: CYTH-like_AC_IV-like; cd07890 1121448010672 dimer interface [polypeptide binding]; other site 1121448010673 putative metal binding residues [ion binding]; other site 1121448010674 Uncharacterized conserved protein [Function unknown]; Region: COG2127 1121448010675 ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639 1121448010676 Clp amino terminal domain; Region: Clp_N; pfam02861 1121448010677 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1121448010678 Walker A motif; other site 1121448010679 ATP binding site [chemical binding]; other site 1121448010680 Walker B motif; other site 1121448010681 arginine finger; other site 1121448010682 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1121448010683 Walker A motif; other site 1121448010684 ATP binding site [chemical binding]; other site 1121448010685 Walker B motif; other site 1121448010686 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1121448010687 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 1121448010688 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1121448010689 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1121448010690 metal binding site [ion binding]; metal-binding site 1121448010691 active site 1121448010692 I-site; other site 1121448010693 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1121448010694 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1121448010695 amphi-Trp domain; Region: amphi-Trp; TIGR04354 1121448010696 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 1121448010697 Acetolactate synthase, small (regulatory) subunit [Amino acid transport and metabolism]; Region: IlvH; COG0440 1121448010698 putative valine binding site [chemical binding]; other site 1121448010699 dimer interface [polypeptide binding]; other site 1121448010700 acetolactate synthase catalytic subunit; Validated; Region: PRK08155 1121448010701 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1121448010702 PYR/PP interface [polypeptide binding]; other site 1121448010703 dimer interface [polypeptide binding]; other site 1121448010704 TPP binding site [chemical binding]; other site 1121448010705 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1121448010706 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1121448010707 TPP-binding site [chemical binding]; other site 1121448010708 dimer interface [polypeptide binding]; other site 1121448010709 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08332 1121448010710 Desulforedoxin (DSRD) domain; a small non-heme iron domain present in the desulforedoxin (rubredoxin oxidoreductase) and desulfoferrodoxin proteins of some archeael and bacterial methanogens and sulfate/sulfur reducers. Desulforedoxin is a small; Region: DSRD; cd00974 1121448010711 non-heme iron binding site [ion binding]; other site 1121448010712 dimer interface [polypeptide binding]; other site 1121448010713 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 1121448010714 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 1121448010715 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 1121448010716 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 1121448010717 putative active site [active] 1121448010718 putative substrate binding site [chemical binding]; other site 1121448010719 putative cosubstrate binding site; other site 1121448010720 catalytic site [active] 1121448010721 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 1121448010722 phosphoglyceromutase; Provisional; Region: PRK05434 1121448010723 Oligomerisation domain; Region: Oligomerisation; pfam02410 1121448010724 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 1121448010725 Dynamin family; Region: Dynamin_N; pfam00350 1121448010726 G1 box; other site 1121448010727 GTP/Mg2+ binding site [chemical binding]; other site 1121448010728 G2 box; other site 1121448010729 Switch I region; other site 1121448010730 G3 box; other site 1121448010731 Switch II region; other site 1121448010732 G4 box; other site 1121448010733 G5 box; other site 1121448010734 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1121448010735 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 1121448010736 acyl-activating enzyme (AAE) consensus motif; other site 1121448010737 AMP binding site [chemical binding]; other site 1121448010738 active site 1121448010739 CoA binding site [chemical binding]; other site 1121448010740 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 1121448010741 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1121448010742 Walker A/P-loop; other site 1121448010743 ATP binding site [chemical binding]; other site 1121448010744 Q-loop/lid; other site 1121448010745 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1121448010746 ABC transporter signature motif; other site 1121448010747 Walker B; other site 1121448010748 D-loop; other site 1121448010749 H-loop/switch region; other site 1121448010750 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 1121448010751 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1121448010752 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 1121448010753 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1121448010754 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 1121448010755 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 1121448010756 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 1121448010757 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1121448010758 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 1121448010759 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1121448010760 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1121448010761 putative substrate translocation pore; other site 1121448010762 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 1121448010763 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 1121448010764 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1121448010765 motif II; other site 1121448010766 YGGT family; Region: YGGT; pfam02325 1121448010767 Uncharacterized ACR, YggU family COG1872; Region: DUF167; cl00811 1121448010768 isoleucyl-tRNA synthetase; Region: PLN02843 1121448010769 acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118 1121448010770 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1121448010771 PYR/PP interface [polypeptide binding]; other site 1121448010772 dimer interface [polypeptide binding]; other site 1121448010773 TPP binding site [chemical binding]; other site 1121448010774 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1121448010775 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1121448010776 TPP-binding site [chemical binding]; other site 1121448010777 dimer interface [polypeptide binding]; other site 1121448010778 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 1121448010779 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 1121448010780 putative valine binding site [chemical binding]; other site 1121448010781 dimer interface [polypeptide binding]; other site 1121448010782 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 1121448010783 ketol-acid reductoisomerase; Provisional; Region: PRK05479 1121448010784 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 1121448010785 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1121448010786 PilZ domain; Region: PilZ; pfam07238 1121448010787 FHA domain; Region: FHA; pfam00498 1121448010788 phosphopeptide binding site; other site 1121448010789 Bacterial SH3 domain; Region: SH3_3; cl17532 1121448010790 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 1121448010791 active site clefts [active] 1121448010792 zinc binding site [ion binding]; other site 1121448010793 dimer interface [polypeptide binding]; other site 1121448010794 Proteolipid membrane potential modulator; Region: Pmp3; pfam01679 1121448010795 Predicted transporter component [General function prediction only]; Region: COG2391 1121448010796 Sulphur transport; Region: Sulf_transp; pfam04143 1121448010797 peroxiredoxin; Provisional; Region: PRK13189 1121448010798 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 1121448010799 dimer interface [polypeptide binding]; other site 1121448010800 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1121448010801 catalytic triad [active] 1121448010802 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1121448010803 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1121448010804 active site 1121448010805 HIGH motif; other site 1121448010806 nucleotide binding site [chemical binding]; other site 1121448010807 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1121448010808 active site 1121448010809 KMSKS motif; other site 1121448010810 EAL domain; Region: EAL; pfam00563 1121448010811 Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434 1121448010812 Putative catalytic domain of lipopolysaccharide biosynthesis protein WalW and its bacterial homologs; Region: CE4_WalW; cd10935 1121448010813 putative active site [active] 1121448010814 putative catalytic site [active] 1121448010815 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1121448010816 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1121448010817 NAD(P) binding site [chemical binding]; other site 1121448010818 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1121448010819 radical SAM/SPASM domain protein, ACGX system; Region: rSAM_ACGX; TIGR04340 1121448010820 FeS/SAM binding site; other site 1121448010821 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 1121448010822 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1121448010823 Glycosyl transferase family 1; Region: Glyco_trans_1_3; pfam13528 1121448010824 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1121448010825 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 1121448010826 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 1121448010827 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 1121448010828 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 1121448010829 Walker A/P-loop; other site 1121448010830 ATP binding site [chemical binding]; other site 1121448010831 Q-loop/lid; other site 1121448010832 ABC transporter signature motif; other site 1121448010833 Walker B; other site 1121448010834 D-loop; other site 1121448010835 H-loop/switch region; other site 1121448010836 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1121448010837 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1121448010838 binding surface 1121448010839 TPR repeat; Region: TPR_11; pfam13414 1121448010840 TPR motif; other site 1121448010841 TPR repeat; Region: TPR_11; pfam13414 1121448010842 TPR repeat; Region: TPR_11; pfam13414 1121448010843 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1121448010844 TPR motif; other site 1121448010845 binding surface 1121448010846 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1121448010847 flagellin; Provisional; Region: PRK12802 1121448010848 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1121448010849 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1121448010850 Putative exonuclease, RdgC; Region: RdgC; cl01122