-- dump date 20140619_064546 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1322246000001 DnaA N-terminal domain; Region: DnaA_N; pfam11638 1322246000002 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 1322246000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1322246000004 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1322246000005 Walker A motif; other site 1322246000006 ATP binding site [chemical binding]; other site 1322246000007 Walker B motif; other site 1322246000008 arginine finger; other site 1322246000009 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1322246000010 DnaA box-binding interface [nucleotide binding]; other site 1322246000011 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1322246000012 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 1322246000013 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1322246000014 active site 1322246000015 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1322246000016 protein binding site [polypeptide binding]; other site 1322246000017 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 1322246000018 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 1322246000019 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 1322246000020 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 1322246000021 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 1322246000022 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 1322246000023 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1322246000024 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 1322246000025 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 1322246000026 catalytic residue [active] 1322246000027 putative FPP diphosphate binding site; other site 1322246000028 putative FPP binding hydrophobic cleft; other site 1322246000029 dimer interface [polypeptide binding]; other site 1322246000030 putative IPP diphosphate binding site; other site 1322246000031 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1322246000032 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1322246000033 hinge region; other site 1322246000034 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1322246000035 putative nucleotide binding site [chemical binding]; other site 1322246000036 uridine monophosphate binding site [chemical binding]; other site 1322246000037 homohexameric interface [polypeptide binding]; other site 1322246000038 elongation factor Ts; Provisional; Region: tsf; PRK09377 1322246000039 UBA/TS-N domain; Region: UBA; pfam00627 1322246000040 Elongation factor TS; Region: EF_TS; pfam00889 1322246000041 Elongation factor TS; Region: EF_TS; pfam00889 1322246000042 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1322246000043 rRNA interaction site [nucleotide binding]; other site 1322246000044 S8 interaction site; other site 1322246000045 putative laminin-1 binding site; other site 1322246000046 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1322246000047 TPR motif; other site 1322246000048 binding surface 1322246000049 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1322246000050 active site 1322246000051 Radical SAM superfamily; Region: Radical_SAM; pfam04055 1322246000052 spore photoproduct lyase; Region: photo_TT_lyase; cl15393 1322246000053 ParB-like nuclease domain; Region: ParBc; pfam02195 1322246000054 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 1322246000055 elongation factor G; Reviewed; Region: PRK12740 1322246000056 G1 box; other site 1322246000057 putative GEF interaction site [polypeptide binding]; other site 1322246000058 GTP/Mg2+ binding site [chemical binding]; other site 1322246000059 Switch I region; other site 1322246000060 G2 box; other site 1322246000061 G3 box; other site 1322246000062 Switch II region; other site 1322246000063 G4 box; other site 1322246000064 G5 box; other site 1322246000065 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1322246000066 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1322246000067 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1322246000068 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1322246000069 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1322246000070 putative acyl-acceptor binding pocket; other site 1322246000071 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1322246000072 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1322246000073 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1322246000074 Putative heavy-metal-binding; Region: YbjQ_1; pfam01906 1322246000075 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 1322246000076 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1322246000077 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1322246000078 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1322246000079 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1322246000080 metal binding site [ion binding]; metal-binding site 1322246000081 active site 1322246000082 I-site; other site 1322246000083 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1322246000084 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1322246000085 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1322246000086 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1322246000087 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1322246000088 fumarate reductase cytochrome b-556 subunit; Provisional; Region: PRK13554 1322246000089 Quinol:fumarate reductase (QFR) Type B subfamily, transmembrane subunit; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinone...; Region: QFR_TypeB_TM; cd00581 1322246000090 Iron-sulfur protein interface; other site 1322246000091 proximal heme binding site [chemical binding]; other site 1322246000092 distal heme binding site [chemical binding]; other site 1322246000093 dimer interface [polypeptide binding]; other site 1322246000094 fumarate reductase flavoprotein subunit; Provisional; Region: PRK08626 1322246000095 L-aspartate oxidase; Provisional; Region: PRK06175 1322246000096 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1322246000097 fumarate reductase iron-sulfur subunit; Provisional; Region: frdB; PRK13552 1322246000098 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1322246000099 fumarate hydratase; Provisional; Region: PRK06246 1322246000100 Fumarase C-terminus; Region: Fumerase_C; cl00795 1322246000101 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 1322246000102 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1322246000103 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1322246000104 homodimer interface [polypeptide binding]; other site 1322246000105 catalytic residue [active] 1322246000106 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 1322246000107 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1322246000108 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1322246000109 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1322246000110 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1322246000111 active site residue [active] 1322246000112 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1322246000113 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1322246000114 active site 1322246000115 phosphorylation site [posttranslational modification] 1322246000116 intermolecular recognition site; other site 1322246000117 dimerization interface [polypeptide binding]; other site 1322246000118 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 1322246000119 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1322246000120 Walker A/P-loop; other site 1322246000121 ATP binding site [chemical binding]; other site 1322246000122 Q-loop/lid; other site 1322246000123 ABC transporter signature motif; other site 1322246000124 Walker B; other site 1322246000125 D-loop; other site 1322246000126 H-loop/switch region; other site 1322246000127 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1322246000128 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1322246000129 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1322246000130 Walker A/P-loop; other site 1322246000131 ATP binding site [chemical binding]; other site 1322246000132 Q-loop/lid; other site 1322246000133 ABC transporter signature motif; other site 1322246000134 Walker B; other site 1322246000135 D-loop; other site 1322246000136 H-loop/switch region; other site 1322246000137 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1322246000138 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1322246000139 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1322246000140 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1322246000141 dimer interface [polypeptide binding]; other site 1322246000142 conserved gate region; other site 1322246000143 putative PBP binding loops; other site 1322246000144 ABC-ATPase subunit interface; other site 1322246000145 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1322246000146 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1322246000147 dimer interface [polypeptide binding]; other site 1322246000148 conserved gate region; other site 1322246000149 putative PBP binding loops; other site 1322246000150 ABC-ATPase subunit interface; other site 1322246000151 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1322246000152 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498 1322246000153 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 1322246000154 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cd02065 1322246000155 B12 binding site [chemical binding]; other site 1322246000156 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1322246000157 FeS/SAM binding site; other site 1322246000158 radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936 1322246000159 Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; pfam10105 1322246000160 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1322246000161 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 1322246000162 Na binding site [ion binding]; other site 1322246000163 Protein of unknown function, DUF485; Region: DUF485; pfam04341 1322246000164 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1322246000165 metal binding triad; other site 1322246000166 Putative nucleotidyltransferase substrate binding domain; Region: DUF294_C; pfam10335 1322246000167 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1322246000168 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1322246000169 putative active site [active] 1322246000170 Domain of unknown function (DUF3393); Region: DUF3393; pfam11873 1322246000171 murein transglycosylase C; Provisional; Region: mltC; PRK11671 1322246000172 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1322246000173 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1322246000174 catalytic residue [active] 1322246000175 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 1322246000176 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 1322246000177 putative active site; other site 1322246000178 catalytic residue [active] 1322246000179 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1322246000180 homotrimer interaction site [polypeptide binding]; other site 1322246000181 putative active site [active] 1322246000182 Uncharacterized membrane protein [Function unknown]; Region: SpmB; cl17667 1322246000183 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 1322246000184 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 1322246000185 G1 box; other site 1322246000186 GTP/Mg2+ binding site [chemical binding]; other site 1322246000187 Switch I region; other site 1322246000188 G2 box; other site 1322246000189 G3 box; other site 1322246000190 Switch II region; other site 1322246000191 G4 box; other site 1322246000192 G5 box; other site 1322246000193 Nucleoside recognition; Region: Gate; pfam07670 1322246000194 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 1322246000195 Nucleoside recognition; Region: Gate; pfam07670 1322246000196 FeoA domain; Region: FeoA; pfam04023 1322246000197 PilZ domain; Region: PilZ; pfam07238 1322246000198 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1322246000199 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1322246000200 putative active site [active] 1322246000201 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1322246000202 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1322246000203 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1322246000204 inhibitor-cofactor binding pocket; inhibition site 1322246000205 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1322246000206 catalytic residue [active] 1322246000207 UDP-N-acetylglucosamine 4,6-dehydratase; Region: PseB; TIGR03589 1322246000208 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 1322246000209 NAD(P) binding site [chemical binding]; other site 1322246000210 homodimer interface [polypeptide binding]; other site 1322246000211 substrate binding site [chemical binding]; other site 1322246000212 active site 1322246000213 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1322246000214 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1322246000215 Walker A/P-loop; other site 1322246000216 ATP binding site [chemical binding]; other site 1322246000217 Q-loop/lid; other site 1322246000218 ABC transporter signature motif; other site 1322246000219 Walker B; other site 1322246000220 D-loop; other site 1322246000221 H-loop/switch region; other site 1322246000222 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1322246000223 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1322246000224 dimer interface [polypeptide binding]; other site 1322246000225 conserved gate region; other site 1322246000226 putative PBP binding loops; other site 1322246000227 ABC-ATPase subunit interface; other site 1322246000228 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1322246000229 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1322246000230 substrate binding pocket [chemical binding]; other site 1322246000231 membrane-bound complex binding site; other site 1322246000232 hinge residues; other site 1322246000233 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1322246000234 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1322246000235 active site 1322246000236 phosphorylation site [posttranslational modification] 1322246000237 intermolecular recognition site; other site 1322246000238 dimerization interface [polypeptide binding]; other site 1322246000239 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1322246000240 dimer interface [polypeptide binding]; other site 1322246000241 phosphorylation site [posttranslational modification] 1322246000242 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1322246000243 ATP binding site [chemical binding]; other site 1322246000244 Mg2+ binding site [ion binding]; other site 1322246000245 G-X-G motif; other site 1322246000246 Response regulator receiver domain; Region: Response_reg; pfam00072 1322246000247 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1322246000248 active site 1322246000249 phosphorylation site [posttranslational modification] 1322246000250 intermolecular recognition site; other site 1322246000251 dimerization interface [polypeptide binding]; other site 1322246000252 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1322246000253 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1322246000254 MltA specific insert domain; Region: MltA; smart00925 1322246000255 3D domain; Region: 3D; pfam06725 1322246000256 Transcriptional regulator; Region: Rrf2; cl17282 1322246000257 Rrf2 family protein; Region: rrf2_super; TIGR00738 1322246000258 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 1322246000259 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 1322246000260 active site 1322246000261 4Fe-4S binding domain; Region: Fer4_6; pfam12837 1322246000262 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 1322246000263 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1322246000264 active site 1322246000265 FMN binding site [chemical binding]; other site 1322246000266 substrate binding site [chemical binding]; other site 1322246000267 3Fe-4S cluster binding site [ion binding]; other site 1322246000268 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cl00239 1322246000269 domain_subunit interface; other site 1322246000270 putative glutamate synthase (NADPH) small subunit; Provisional; Region: PRK12771 1322246000271 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1322246000272 4Fe-4S binding domain; Region: Fer4; pfam00037 1322246000273 Bacterial protein of unknown function (DUF922); Region: DUF922; cl02415 1322246000274 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 1322246000275 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1322246000276 binding surface 1322246000277 TPR motif; other site 1322246000278 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 1322246000279 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 1322246000280 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1322246000281 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 1322246000282 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 1322246000283 Protein of unknown function (DUF3450); Region: DUF3450; pfam11932 1322246000284 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 1322246000285 Protein of unknown function (DUF3450); Region: DUF3450; pfam11932 1322246000286 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1322246000287 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1322246000288 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1322246000289 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1322246000290 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1322246000291 active site 1322246000292 O-Antigen ligase; Region: Wzy_C; pfam04932 1322246000293 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1322246000294 YcaO-like family; Region: YcaO; pfam02624 1322246000295 thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604 1322246000296 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 1322246000297 active site 1322246000298 catalytic triad [active] 1322246000299 oxyanion hole [active] 1322246000300 switch loop; other site 1322246000301 Putative exonuclease, RdgC; Region: RdgC; cl01122 1322246000302 PilZ domain; Region: PilZ; pfam07238 1322246000303 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 1322246000304 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 1322246000305 substrate binding site; other site 1322246000306 tetramer interface; other site 1322246000307 Protein of unknown function (DUF1614); Region: DUF1614; pfam07758 1322246000308 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1322246000309 MPT binding site; other site 1322246000310 trimer interface [polypeptide binding]; other site 1322246000311 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 1322246000312 Transglycosylase SLT domain; Region: SLT_2; pfam13406 1322246000313 murein hydrolase B; Provisional; Region: PRK10760; cl17906 1322246000314 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1322246000315 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1322246000316 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1322246000317 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1322246000318 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1322246000319 active site 1322246000320 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 1322246000321 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1322246000322 catalytic core [active] 1322246000323 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1322246000324 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 1322246000325 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1322246000326 minor groove reading motif; other site 1322246000327 helix-hairpin-helix signature motif; other site 1322246000328 substrate binding pocket [chemical binding]; other site 1322246000329 active site 1322246000330 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 1322246000331 active site 1322246000332 8-oxo-dGMP binding site [chemical binding]; other site 1322246000333 nudix motif; other site 1322246000334 metal binding site [ion binding]; metal-binding site 1322246000335 Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293 1322246000336 Domain of unknown function (DUF814); Region: DUF814; pfam05670 1322246000337 RNA polymerase-binding protein DksA; Region: dksA; TIGR02420 1322246000338 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 1322246000339 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 1322246000340 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 1322246000341 2-isopropylmalate synthase; Validated; Region: PRK00915 1322246000342 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 1322246000343 active site 1322246000344 catalytic residues [active] 1322246000345 metal binding site [ion binding]; metal-binding site 1322246000346 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 1322246000347 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1322246000348 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 1322246000349 substrate binding site [chemical binding]; other site 1322246000350 ligand binding site [chemical binding]; other site 1322246000351 3-isopropylmalate dehydratase small subunit; Reviewed; Region: leuD; PRK00439 1322246000352 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1322246000353 substrate binding site [chemical binding]; other site 1322246000354 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 1322246000355 tartrate dehydrogenase; Region: TTC; TIGR02089 1322246000356 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1322246000357 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 1322246000358 GIY-YIG motif/motif A; other site 1322246000359 putative active site [active] 1322246000360 putative metal binding site [ion binding]; other site 1322246000361 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1322246000362 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1322246000363 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1322246000364 Walker A/P-loop; other site 1322246000365 ATP binding site [chemical binding]; other site 1322246000366 Q-loop/lid; other site 1322246000367 ABC transporter signature motif; other site 1322246000368 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1322246000369 Walker B; other site 1322246000370 D-loop; other site 1322246000371 ABC transporter; Region: ABC_tran_2; pfam12848 1322246000372 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1322246000373 Mnd1 family; Region: Mnd1; pfam03962 1322246000374 Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits; Region: iSH2_PI3K_IA_R; cl17108 1322246000375 heterodimer interface [polypeptide binding]; other site 1322246000376 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 1322246000377 active site 1322246000378 8-oxo-dGMP binding site [chemical binding]; other site 1322246000379 nudix motif; other site 1322246000380 metal binding site [ion binding]; metal-binding site 1322246000381 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 1322246000382 FAD binding site [chemical binding]; other site 1322246000383 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 1322246000384 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1322246000385 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1322246000386 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 1322246000387 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1322246000388 catalytic residue [active] 1322246000389 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1322246000390 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 1322246000391 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 1322246000392 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1322246000393 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1322246000394 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1322246000395 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1322246000396 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1322246000397 ligand binding site [chemical binding]; other site 1322246000398 flexible hinge region; other site 1322246000399 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 1322246000400 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 1322246000401 NADP binding site [chemical binding]; other site 1322246000402 active site 1322246000403 putative substrate binding site [chemical binding]; other site 1322246000404 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 1322246000405 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 1322246000406 NAD binding site [chemical binding]; other site 1322246000407 substrate binding site [chemical binding]; other site 1322246000408 homodimer interface [polypeptide binding]; other site 1322246000409 active site 1322246000410 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 1322246000411 putative molybdopterin-guanine dinucleotide biosynthesis protein MobB/FeS domain-containing protein protein; Provisional; Region: PRK14494 1322246000412 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1322246000413 Putative Fe-S cluster; Region: FeS; cl17515 1322246000414 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1322246000415 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1322246000416 Walker A/P-loop; other site 1322246000417 ATP binding site [chemical binding]; other site 1322246000418 Q-loop/lid; other site 1322246000419 ABC transporter signature motif; other site 1322246000420 Walker B; other site 1322246000421 D-loop; other site 1322246000422 H-loop/switch region; other site 1322246000423 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1322246000424 dimer interface [polypeptide binding]; other site 1322246000425 conserved gate region; other site 1322246000426 putative PBP binding loops; other site 1322246000427 ABC-ATPase subunit interface; other site 1322246000428 PBP superfamily domain; Region: PBP_like_2; pfam12849 1322246000429 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1322246000430 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; cl17549 1322246000431 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1322246000432 thiazole biosynthesis adenylyltransferase ThiF, E. coli subfamily; Region: adenyl_thiF; TIGR02356 1322246000433 ATP binding site [chemical binding]; other site 1322246000434 substrate interface [chemical binding]; other site 1322246000435 Ubiquitin-like proteins; Region: UBQ; cl00155 1322246000436 charged pocket; other site 1322246000437 hydrophobic patch; other site 1322246000438 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; smart00790 1322246000439 Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414 1322246000440 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 1322246000441 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1322246000442 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1322246000443 DNA binding site [nucleotide binding] 1322246000444 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1322246000445 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 1322246000446 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 1322246000447 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 1322246000448 haemagglutination activity domain; Region: Haemagg_act; pfam05860 1322246000449 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 1322246000450 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 1322246000451 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 1322246000452 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 1322246000453 nucleophilic elbow; other site 1322246000454 catalytic triad; other site 1322246000455 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1322246000456 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1322246000457 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1322246000458 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1322246000459 Walker A motif; other site 1322246000460 ATP binding site [chemical binding]; other site 1322246000461 Walker B motif; other site 1322246000462 Integrase core domain; Region: rve_3; pfam13683 1322246000463 HTH-like domain; Region: HTH_21; pfam13276 1322246000464 Integrase core domain; Region: rve; pfam00665 1322246000465 electron transport complex, RnfABCDGE type, B subunit; Region: rnfB; TIGR01944 1322246000466 4Fe-4S binding domain; Region: Fer4; pfam00037 1322246000467 putative oxidoreductase; Provisional; Region: PRK12831 1322246000468 electron transport complex, RnfABCDGE type, A subunit; Region: rnfA; TIGR01943 1322246000469 electron transport complex RsxE subunit; Provisional; Region: PRK12405 1322246000470 FMN-binding domain; Region: FMN_bind; cl01081 1322246000471 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; pfam03116 1322246000472 electron transport complex, RnfABCDGE type, C subunit; Region: rnfC; TIGR01945 1322246000473 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1322246000474 Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785 1322246000475 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 1322246000476 dimer interface [polypeptide binding]; other site 1322246000477 active site 1322246000478 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 1322246000479 YibE/F-like protein; Region: YibE_F; pfam07907 1322246000480 Flagellar protein YcgR; Region: YcgR_2; pfam12945 1322246000481 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1322246000482 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1322246000483 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 1322246000484 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 1322246000485 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1322246000486 Zn2+ binding site [ion binding]; other site 1322246000487 Mg2+ binding site [ion binding]; other site 1322246000488 Response regulator receiver domain; Region: Response_reg; pfam00072 1322246000489 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1322246000490 active site 1322246000491 phosphorylation site [posttranslational modification] 1322246000492 intermolecular recognition site; other site 1322246000493 dimerization interface [polypeptide binding]; other site 1322246000494 Protein of unknown function (DUF1517); Region: DUF1517; cl01807 1322246000495 Tim44-like domain; Region: Tim44; cl09208 1322246000496 Putative methyltransferase; Region: Methyltransf_16; pfam10294 1322246000497 putative methanogenesis marker protein 1; Region: methan_mark_1; TIGR03266 1322246000498 YcaO-like family; Region: YcaO; pfam02624 1322246000499 TPR repeat; Region: TPR_11; pfam13414 1322246000500 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1322246000501 binding surface 1322246000502 TPR motif; other site 1322246000503 TPR repeat; Region: TPR_11; pfam13414 1322246000504 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920 1322246000505 DsrC like protein; Region: DsrC; pfam04358 1322246000506 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 1322246000507 Protein of unknown function (DUF1385); Region: DUF1385; pfam07136 1322246000508 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1322246000509 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1322246000510 RF-1 domain; Region: RF-1; pfam00472 1322246000511 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 1322246000512 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1322246000513 S-adenosylmethionine binding site [chemical binding]; other site 1322246000514 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 1322246000515 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 1322246000516 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 1322246000517 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 1322246000518 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1322246000519 active site 1322246000520 phosphorylation site [posttranslational modification] 1322246000521 intermolecular recognition site; other site 1322246000522 dimerization interface [polypeptide binding]; other site 1322246000523 RNA polymerase sigma factor, FliA/WhiG family; Region: FliA_WhiG; TIGR02479 1322246000524 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1322246000525 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1322246000526 DNA binding residues [nucleotide binding] 1322246000527 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 1322246000528 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 1322246000529 P-loop; other site 1322246000530 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 1322246000531 flagellar biosynthetic protein FlhF; Region: FlhF; TIGR03499 1322246000532 SRP54-type protein, GTPase domain; Region: SRP54; smart00962 1322246000533 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 1322246000534 FHIPEP family; Region: FHIPEP; pfam00771 1322246000535 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 1322246000536 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 1322246000537 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 1322246000538 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1322246000539 Peptidase family M23; Region: Peptidase_M23; pfam01551 1322246000540 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 1322246000541 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 1322246000542 Ligand Binding Site [chemical binding]; other site 1322246000543 Domain of unknown function (DUF4340); Region: DUF4340; pfam14238 1322246000544 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 1322246000545 chaperone protein DnaJ; Provisional; Region: PRK14301 1322246000546 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1322246000547 HSP70 interaction site [polypeptide binding]; other site 1322246000548 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 1322246000549 substrate binding site [polypeptide binding]; other site 1322246000550 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1322246000551 Zn binding sites [ion binding]; other site 1322246000552 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1322246000553 dimer interface [polypeptide binding]; other site 1322246000554 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 1322246000555 trimer interface [polypeptide binding]; other site 1322246000556 dimer interface [polypeptide binding]; other site 1322246000557 putative active site [active] 1322246000558 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1322246000559 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1322246000560 active site residue [active] 1322246000561 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1322246000562 active site residue [active] 1322246000563 Na/Pi-cotransporter; Region: NaPi_cotrn_rel; TIGR00704 1322246000564 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 1322246000565 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 1322246000566 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1322246000567 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1322246000568 dimer interface [polypeptide binding]; other site 1322246000569 putative anticodon binding site; other site 1322246000570 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 1322246000571 motif 1; other site 1322246000572 active site 1322246000573 motif 2; other site 1322246000574 motif 3; other site 1322246000575 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 1322246000576 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1322246000577 FtsX-like permease family; Region: FtsX; pfam02687 1322246000578 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1322246000579 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1322246000580 Walker A/P-loop; other site 1322246000581 ATP binding site [chemical binding]; other site 1322246000582 Q-loop/lid; other site 1322246000583 ABC transporter signature motif; other site 1322246000584 Walker B; other site 1322246000585 D-loop; other site 1322246000586 H-loop/switch region; other site 1322246000587 Protein of unknown function (DUF2380); Region: DUF3280; pfam11684 1322246000588 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 1322246000589 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1322246000590 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1322246000591 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1322246000592 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1322246000593 Surface antigen; Region: Bac_surface_Ag; pfam01103 1322246000594 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 1322246000595 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 1322246000596 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 1322246000597 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 1322246000598 trimer interface [polypeptide binding]; other site 1322246000599 active site 1322246000600 UDP-GlcNAc binding site [chemical binding]; other site 1322246000601 lipid binding site [chemical binding]; lipid-binding site 1322246000602 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1322246000603 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 1322246000604 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 1322246000605 active site 1322246000606 Protein of unknown function (DUF1009); Region: DUF1009; pfam06230 1322246000607 Protein of unknown function DUF89; Region: DUF89; cl15397 1322246000608 AsmA family; Region: AsmA; pfam05170 1322246000609 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 1322246000610 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 1322246000611 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1322246000612 putative active site [active] 1322246000613 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 1322246000614 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 1322246000615 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 1322246000616 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1322246000617 minor groove reading motif; other site 1322246000618 helix-hairpin-helix signature motif; other site 1322246000619 substrate binding pocket [chemical binding]; other site 1322246000620 active site 1322246000621 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 1322246000622 Uncharacterized protein involved in tolerance to divalent cations [Inorganic ion transport and metabolism]; Region: CutA; COG1324 1322246000623 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 1322246000624 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1322246000625 substrate binding site [chemical binding]; other site 1322246000626 ATP binding site [chemical binding]; other site 1322246000627 Phosphotransferase enzyme family; Region: APH; pfam01636 1322246000628 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1322246000629 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1322246000630 active site 1322246000631 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14337 1322246000632 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1322246000633 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 1322246000634 FeS/SAM binding site; other site 1322246000635 TRAM domain; Region: TRAM; cl01282 1322246000636 Bifunctional nuclease; Region: DNase-RNase; pfam02577 1322246000637 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432 1322246000638 active site 1322246000639 hypothetical protein; Provisional; Region: PRK06361 1322246000640 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 1322246000641 TolR protein; Region: tolR; TIGR02801 1322246000642 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1322246000643 TonB C terminal; Region: TonB_2; pfam13103 1322246000644 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 1322246000645 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1322246000646 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1322246000647 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1322246000648 ligand binding site [chemical binding]; other site 1322246000649 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 1322246000650 tetramer interfaces [polypeptide binding]; other site 1322246000651 binuclear metal-binding site [ion binding]; other site 1322246000652 Maf-like protein; Region: Maf; pfam02545 1322246000653 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1322246000654 active site 1322246000655 dimer interface [polypeptide binding]; other site 1322246000656 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1322246000657 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1322246000658 ligand binding site [chemical binding]; other site 1322246000659 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 1322246000660 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 1322246000661 glucokinase, proteobacterial type; Region: glk; TIGR00749 1322246000662 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1322246000663 nucleotide binding site [chemical binding]; other site 1322246000664 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1322246000665 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1322246000666 dihydrolipoamide dehydrogenase; Validated; Region: PRK06292 1322246000667 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1322246000668 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1322246000669 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1322246000670 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1322246000671 active site 1322246000672 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 1322246000673 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 1322246000674 putative ligand binding site [chemical binding]; other site 1322246000675 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1322246000676 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1322246000677 TM-ABC transporter signature motif; other site 1322246000678 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1322246000679 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1322246000680 TM-ABC transporter signature motif; other site 1322246000681 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 1322246000682 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1322246000683 Walker A/P-loop; other site 1322246000684 ATP binding site [chemical binding]; other site 1322246000685 Q-loop/lid; other site 1322246000686 ABC transporter signature motif; other site 1322246000687 Walker B; other site 1322246000688 D-loop; other site 1322246000689 H-loop/switch region; other site 1322246000690 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1322246000691 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1322246000692 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1322246000693 substrate binding pocket [chemical binding]; other site 1322246000694 membrane-bound complex binding site; other site 1322246000695 hinge residues; other site 1322246000696 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1322246000697 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1322246000698 dimer interface [polypeptide binding]; other site 1322246000699 conserved gate region; other site 1322246000700 putative PBP binding loops; other site 1322246000701 ABC-ATPase subunit interface; other site 1322246000702 dGTP triphosphohydrolase [Nucleotide transport and metabolism]; Region: Dgt; COG0232 1322246000703 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1322246000704 Zn2+ binding site [ion binding]; other site 1322246000705 Mg2+ binding site [ion binding]; other site 1322246000706 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 1322246000707 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 1322246000708 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1322246000709 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1322246000710 active site 1322246000711 cofactor-independent phosphoglycerate mutase; Provisional; Region: PRK04200 1322246000712 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: PhosphMutase; cl17294 1322246000713 homoserine dehydrogenase; Provisional; Region: PRK06349 1322246000714 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1322246000715 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1322246000716 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 1322246000717 aminotransferase; Validated; Region: PRK08175 1322246000718 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1322246000719 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1322246000720 homodimer interface [polypeptide binding]; other site 1322246000721 catalytic residue [active] 1322246000722 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1322246000723 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1322246000724 homodimer interface [polypeptide binding]; other site 1322246000725 substrate-cofactor binding pocket; other site 1322246000726 catalytic residue [active] 1322246000727 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 1322246000728 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1322246000729 Walker A motif; other site 1322246000730 ATP binding site [chemical binding]; other site 1322246000731 Walker B motif; other site 1322246000732 arginine finger; other site 1322246000733 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 1322246000734 hypothetical protein; Validated; Region: PRK00153 1322246000735 recombination protein RecR; Reviewed; Region: recR; PRK00076 1322246000736 RecR protein; Region: RecR; pfam02132 1322246000737 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1322246000738 putative active site [active] 1322246000739 putative metal-binding site [ion binding]; other site 1322246000740 tetramer interface [polypeptide binding]; other site 1322246000741 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 1322246000742 AAA domain; Region: AAA_30; pfam13604 1322246000743 Family description; Region: UvrD_C_2; pfam13538 1322246000744 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 1322246000745 Ferritin-like domain; Region: Ferritin; pfam00210 1322246000746 ferroxidase diiron center [ion binding]; other site 1322246000747 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 1322246000748 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; pfam01558 1322246000749 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 1322246000750 dimer interface [polypeptide binding]; other site 1322246000751 PYR/PP interface [polypeptide binding]; other site 1322246000752 TPP binding site [chemical binding]; other site 1322246000753 substrate binding site [chemical binding]; other site 1322246000754 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Validated; Region: PRK05778 1322246000755 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 1322246000756 TPP-binding site [chemical binding]; other site 1322246000757 Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367 1322246000758 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 1322246000759 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1322246000760 ABC transporter; Region: ABC_tran_2; pfam12848 1322246000761 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1322246000762 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1322246000763 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the GGDEF (DiGuanylate-Cyclase (DGC)) domain. The GGDEF domain has been suggested to be homologous to the adenylyl cyclase catalytic domain and...; Region: CBS_pair_GGDEF_assoc; cd04598 1322246000764 FOG: CBS domain [General function prediction only]; Region: COG0517 1322246000765 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1322246000766 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1322246000767 metal binding site [ion binding]; metal-binding site 1322246000768 active site 1322246000769 I-site; other site 1322246000770 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 1322246000771 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 1322246000772 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1322246000773 ATP binding site [chemical binding]; other site 1322246000774 putative Mg++ binding site [ion binding]; other site 1322246000775 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1322246000776 nucleotide binding region [chemical binding]; other site 1322246000777 ATP-binding site [chemical binding]; other site 1322246000778 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1322246000779 The substrate-binding component of the oligopeptide-binding protein, AppA, from Bacillus subtilis contains the type 2 periplasmic-binding fold; Region: PBP2_AppA_like; cd08514 1322246000780 peptide binding site [polypeptide binding]; other site 1322246000781 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1322246000782 HD domain; Region: HD_4; pfam13328 1322246000783 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1322246000784 synthetase active site [active] 1322246000785 NTP binding site [chemical binding]; other site 1322246000786 metal binding site [ion binding]; metal-binding site 1322246000787 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1322246000788 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1322246000789 purine nucleoside phosphorylase; Provisional; Region: PRK08202 1322246000790 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 1322246000791 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 1322246000792 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 1322246000793 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1322246000794 ligand binding site [chemical binding]; other site 1322246000795 PilZ domain; Region: PilZ; pfam07238 1322246000796 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1322246000797 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1322246000798 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1322246000799 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1322246000800 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; pfam03255 1322246000801 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1322246000802 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1322246000803 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 1322246000804 lipoyl-biotinyl attachment site [posttranslational modification]; other site 1322246000805 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1322246000806 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1322246000807 dimer interface [polypeptide binding]; other site 1322246000808 ssDNA binding site [nucleotide binding]; other site 1322246000809 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1322246000810 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 1322246000811 choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414 1322246000812 Bacillus subtilis NAD+-dependent betaine aldehyde dehydrogenase-like; Region: ALDH_BADH-GbsA; cd07119 1322246000813 glycine betaine aldehyde dehydrogenase; Region: BADH; TIGR01804 1322246000814 tetramerization interface [polypeptide binding]; other site 1322246000815 NAD(P) binding site [chemical binding]; other site 1322246000816 catalytic residues [active] 1322246000817 choline dehydrogenase; Validated; Region: PRK02106 1322246000818 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1322246000819 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1322246000820 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1322246000821 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1322246000822 DNA-binding site [nucleotide binding]; DNA binding site 1322246000823 FCD domain; Region: FCD; cl11656 1322246000824 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 1322246000825 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1322246000826 substrate binding site [chemical binding]; other site 1322246000827 glutamase interaction surface [polypeptide binding]; other site 1322246000828 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 1322246000829 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 1322246000830 putative active site [active] 1322246000831 oxyanion strand; other site 1322246000832 catalytic triad [active] 1322246000833 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1322246000834 HSP70 interaction site [polypeptide binding]; other site 1322246000835 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 1322246000836 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1322246000837 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1322246000838 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 1322246000839 active site 1322246000840 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 1322246000841 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH1; cd08185 1322246000842 putative active site [active] 1322246000843 metal binding site [ion binding]; metal-binding site 1322246000844 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1322246000845 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1322246000846 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 1322246000847 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1322246000848 FMN binding site [chemical binding]; other site 1322246000849 substrate binding site [chemical binding]; other site 1322246000850 putative catalytic residue [active] 1322246000851 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1322246000852 Predicted dehydrogenase [General function prediction only]; Region: COG0579 1322246000853 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1322246000854 putative recombination protein RecB; Provisional; Region: PRK13909 1322246000855 Family description; Region: UvrD_C_2; pfam13538 1322246000856 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 1322246000857 EamA-like transporter family; Region: EamA; pfam00892 1322246000858 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1322246000859 EamA-like transporter family; Region: EamA; pfam00892 1322246000860 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1322246000861 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1322246000862 RNA binding surface [nucleotide binding]; other site 1322246000863 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1322246000864 active site 1322246000865 30S ribosomal protein S1; Provisional; Region: rpsA; PRK13806 1322246000866 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 1322246000867 RNA binding site [nucleotide binding]; other site 1322246000868 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1322246000869 RNA binding site [nucleotide binding]; other site 1322246000870 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1322246000871 RNA binding site [nucleotide binding]; other site 1322246000872 domain interface; other site 1322246000873 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1322246000874 RNA binding site [nucleotide binding]; other site 1322246000875 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cd00164 1322246000876 RNA binding site [nucleotide binding]; other site 1322246000877 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 1322246000878 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 1322246000879 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1322246000880 P loop; other site 1322246000881 GTP binding site [chemical binding]; other site 1322246000882 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 1322246000883 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 1322246000884 putative dimer interface [polypeptide binding]; other site 1322246000885 putative anticodon binding site; other site 1322246000886 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 1322246000887 homodimer interface [polypeptide binding]; other site 1322246000888 motif 1; other site 1322246000889 motif 2; other site 1322246000890 active site 1322246000891 motif 3; other site 1322246000892 Transposase IS200 like; Region: Y1_Tnp; pfam01797 1322246000893 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1322246000894 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1322246000895 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1322246000896 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 1322246000897 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1322246000898 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1322246000899 DNA binding residues [nucleotide binding] 1322246000900 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1322246000901 dimer interface [polypeptide binding]; other site 1322246000902 substrate binding site [chemical binding]; other site 1322246000903 phosphomethylpyrimidine kinase; Provisional; Region: PRK08573 1322246000904 ATP binding site [chemical binding]; other site 1322246000905 Putative aldolase; Region: Aldolase_2; cl00871 1322246000906 trigger factor; Region: tig; TIGR00115 1322246000907 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1322246000908 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1322246000909 Clp protease; Region: CLP_protease; pfam00574 1322246000910 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1322246000911 oligomer interface [polypeptide binding]; other site 1322246000912 active site residues [active] 1322246000913 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1322246000914 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 1322246000915 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1322246000916 Walker A motif; other site 1322246000917 ATP binding site [chemical binding]; other site 1322246000918 Walker B motif; other site 1322246000919 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1322246000920 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 1322246000921 Found in ATP-dependent protease La (LON); Region: LON; smart00464 1322246000922 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1322246000923 Walker A motif; other site 1322246000924 ATP binding site [chemical binding]; other site 1322246000925 Walker B motif; other site 1322246000926 arginine finger; other site 1322246000927 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1322246000928 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 1322246000929 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1322246000930 Peptidase family M23; Region: Peptidase_M23; pfam01551 1322246000931 FOG: CBS domain [General function prediction only]; Region: COG0517 1322246000932 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1322246000933 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 1322246000934 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1322246000935 S-adenosylmethionine binding site [chemical binding]; other site 1322246000936 Domain of unknown function (DUF368); Region: DUF368; pfam04018 1322246000937 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 1322246000938 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 1322246000939 Septum formation initiator; Region: DivIC; pfam04977 1322246000940 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1322246000941 TPR motif; other site 1322246000942 binding surface 1322246000943 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 1322246000944 AMP binding site [chemical binding]; other site 1322246000945 metal binding site [ion binding]; metal-binding site 1322246000946 active site 1322246000947 UGMP family protein; Validated; Region: PRK09604 1322246000948 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 1322246000949 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1322246000950 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1322246000951 catalytic residues [active] 1322246000952 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1322246000953 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1322246000954 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1322246000955 Outer membrane lipoprotein; Region: YfiO; pfam13525 1322246000956 elongation factor G; Reviewed; Region: PRK00007 1322246000957 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1322246000958 G1 box; other site 1322246000959 putative GEF interaction site [polypeptide binding]; other site 1322246000960 GTP/Mg2+ binding site [chemical binding]; other site 1322246000961 Switch I region; other site 1322246000962 G2 box; other site 1322246000963 G3 box; other site 1322246000964 Switch II region; other site 1322246000965 G4 box; other site 1322246000966 G5 box; other site 1322246000967 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1322246000968 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cd01680 1322246000969 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1322246000970 Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; pfam09835 1322246000971 PAS domain; Region: PAS_9; pfam13426 1322246000972 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1322246000973 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1322246000974 dimer interface [polypeptide binding]; other site 1322246000975 putative CheW interface [polypeptide binding]; other site 1322246000976 Heme NO binding; Region: HNOB; pfam07700 1322246000977 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 1322246000978 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1322246000979 putative binding surface; other site 1322246000980 active site 1322246000981 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1322246000982 ATP binding site [chemical binding]; other site 1322246000983 Mg2+ binding site [ion binding]; other site 1322246000984 G-X-G motif; other site 1322246000985 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 1322246000986 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 1322246000987 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1322246000988 active site 1322246000989 phosphorylation site [posttranslational modification] 1322246000990 intermolecular recognition site; other site 1322246000991 dimerization interface [polypeptide binding]; other site 1322246000992 CheB methylesterase; Region: CheB_methylest; pfam01339 1322246000993 PII-like signaling protein [Signal transduction mechanisms]; Region: COG1993 1322246000994 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 1322246000995 Adenylyl cyclase (AC) class IV-like, a subgroup of the CYTH-like superfamily; Region: CYTH-like_AC_IV-like; cd07890 1322246000996 putative active site [active] 1322246000997 putative metal binding residues [ion binding]; other site 1322246000998 signature motif; other site 1322246000999 putative triphosphate binding site [ion binding]; other site 1322246001000 dimer interface [polypeptide binding]; other site 1322246001001 Uncharacterized conserved protein [Function unknown]; Region: COG2127 1322246001002 ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639 1322246001003 Clp amino terminal domain; Region: Clp_N; pfam02861 1322246001004 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1322246001005 Walker A motif; other site 1322246001006 ATP binding site [chemical binding]; other site 1322246001007 Walker B motif; other site 1322246001008 arginine finger; other site 1322246001009 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1322246001010 Walker A motif; other site 1322246001011 ATP binding site [chemical binding]; other site 1322246001012 Walker B motif; other site 1322246001013 arginine finger; other site 1322246001014 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1322246001015 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 1322246001016 Cytochrome c; Region: Cytochrom_C; cl11414 1322246001017 excinuclease ABC subunit B; Provisional; Region: PRK05298 1322246001018 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1322246001019 ATP binding site [chemical binding]; other site 1322246001020 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1322246001021 nucleotide binding region [chemical binding]; other site 1322246001022 ATP-binding site [chemical binding]; other site 1322246001023 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1322246001024 Ion channel; Region: Ion_trans_2; pfam07885 1322246001025 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1322246001026 TrkA-N domain; Region: TrkA_N; pfam02254 1322246001027 TrkA-C domain; Region: TrkA_C; pfam02080 1322246001028 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 1322246001029 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1322246001030 nucleotide binding pocket [chemical binding]; other site 1322246001031 K-X-D-G motif; other site 1322246001032 catalytic site [active] 1322246001033 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1322246001034 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 1322246001035 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1322246001036 Dimer interface [polypeptide binding]; other site 1322246001037 BRCT sequence motif; other site 1322246001038 dihydrodipicolinate reductase; Provisional; Region: PRK00048 1322246001039 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1322246001040 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1322246001041 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 1322246001042 Putative catalytic domain, repeat 1, of Pseudomonas aeruginosa cardiolipin synthase and similar proteins; Region: PLDc_PaCLS_like_1; cd09155 1322246001043 putative active site [active] 1322246001044 catalytic site [active] 1322246001045 Putative catalytic domain, repeat 2, of Pseudomonas aeruginosa cardiolipin synthase and similar proteins; Region: PLDc_PaCLS_like_2; cd09161 1322246001046 putative active site [active] 1322246001047 catalytic site [active] 1322246001048 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1322246001049 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 1322246001050 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1322246001051 putative binding surface; other site 1322246001052 active site 1322246001053 ACT domain-containing protein [General function prediction only]; Region: COG4747 1322246001054 N-terminal ACT domain of a novel protein composed almost entirely of two tandem ACT domains; Region: ACT_Bt0572_1; cd04908 1322246001055 C-terminal ACT domain of a novel protein composed of just two ACT domains; Region: ACT_Bt0572_2; cd04882 1322246001056 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1322246001057 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 1322246001058 acyl-activating enzyme (AAE) consensus motif; other site 1322246001059 AMP binding site [chemical binding]; other site 1322246001060 active site 1322246001061 CoA binding site [chemical binding]; other site 1322246001062 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 1322246001063 FMN binding site [chemical binding]; other site 1322246001064 dimer interface [polypeptide binding]; other site 1322246001065 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 1322246001066 phosphoglyceromutase; Provisional; Region: PRK05434 1322246001067 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 1322246001068 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1322246001069 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1322246001070 dimer interface [polypeptide binding]; other site 1322246001071 putative CheW interface [polypeptide binding]; other site 1322246001072 Cache domain; Region: Cache_1; pfam02743 1322246001073 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1322246001074 EamA-like transporter family; Region: EamA; pfam00892 1322246001075 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 1322246001076 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 1322246001077 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1322246001078 Beta-Casp domain; Region: Beta-Casp; smart01027 1322246001079 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1322246001080 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 1322246001081 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1322246001082 S-adenosylmethionine binding site [chemical binding]; other site 1322246001083 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1322246001084 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1322246001085 active site 1322246001086 (T/H)XGH motif; other site 1322246001087 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1322246001088 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1322246001089 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1322246001090 catalytic core [active] 1322246001091 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 1322246001092 twin arginine translocase protein A; Provisional; Region: tatA; PRK14859 1322246001093 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1322246001094 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1322246001095 active site 1322246001096 motif I; other site 1322246001097 motif II; other site 1322246001098 YGGT family; Region: YGGT; pfam02325 1322246001099 DivIVA protein; Region: DivIVA; pfam05103 1322246001100 DivIVA domain; Region: DivI1A_domain; TIGR03544 1322246001101 acetolactate synthase 3 catalytic subunit; Reviewed; Region: PRK06048 1322246001102 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1322246001103 PYR/PP interface [polypeptide binding]; other site 1322246001104 dimer interface [polypeptide binding]; other site 1322246001105 TPP binding site [chemical binding]; other site 1322246001106 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1322246001107 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1322246001108 TPP-binding site [chemical binding]; other site 1322246001109 dimer interface [polypeptide binding]; other site 1322246001110 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 1322246001111 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 1322246001112 putative valine binding site [chemical binding]; other site 1322246001113 dimer interface [polypeptide binding]; other site 1322246001114 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 1322246001115 ketol-acid reductoisomerase; Provisional; Region: PRK05479 1322246001116 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 1322246001117 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1322246001118 DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335 1322246001119 hypothetical protein; Provisional; Region: PRK04164 1322246001120 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1322246001121 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 1322246001122 homodimer interaction site [polypeptide binding]; other site 1322246001123 cofactor binding site; other site 1322246001124 thiamine monophosphate kinase; Provisional; Region: PRK05731 1322246001125 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 1322246001126 ATP binding site [chemical binding]; other site 1322246001127 dimerization interface [polypeptide binding]; other site 1322246001128 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1322246001129 Part of AAA domain; Region: AAA_19; pfam13245 1322246001130 Family description; Region: UvrD_C_2; pfam13538 1322246001131 Uncharacterized conserved protein [Function unknown]; Region: COG3379 1322246001132 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 1322246001133 Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090 1322246001134 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1322246001135 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 1322246001136 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1322246001137 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1322246001138 Walker A/P-loop; other site 1322246001139 ATP binding site [chemical binding]; other site 1322246001140 Q-loop/lid; other site 1322246001141 ABC transporter signature motif; other site 1322246001142 Walker B; other site 1322246001143 D-loop; other site 1322246001144 H-loop/switch region; other site 1322246001145 cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454 1322246001146 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 1322246001147 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 1322246001148 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1322246001149 Walker A/P-loop; other site 1322246001150 ATP binding site [chemical binding]; other site 1322246001151 Q-loop/lid; other site 1322246001152 ABC transporter signature motif; other site 1322246001153 Walker B; other site 1322246001154 D-loop; other site 1322246001155 H-loop/switch region; other site 1322246001156 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1322246001157 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1322246001158 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1322246001159 Walker A/P-loop; other site 1322246001160 ATP binding site [chemical binding]; other site 1322246001161 Q-loop/lid; other site 1322246001162 ABC transporter signature motif; other site 1322246001163 Walker B; other site 1322246001164 D-loop; other site 1322246001165 H-loop/switch region; other site 1322246001166 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1322246001167 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 1322246001168 Glucose inhibited division protein A; Region: GIDA; pfam01134 1322246001169 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 1322246001170 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1322246001171 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1322246001172 catalytic residue [active] 1322246001173 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1322246001174 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1322246001175 Chemotaxis phosphatase, CheZ; Region: CheZ; cl01219 1322246001176 PilZ domain; Region: PilZ; pfam07238 1322246001177 NIL domain; Region: NIL; pfam09383 1322246001178 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 1322246001179 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 1322246001180 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 1322246001181 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 1322246001182 lipoprotein signal peptidase; Provisional; Region: PRK14787 1322246001183 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 1322246001184 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1322246001185 active site 1322246001186 HIGH motif; other site 1322246001187 nucleotide binding site [chemical binding]; other site 1322246001188 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1322246001189 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1322246001190 active site 1322246001191 KMSKS motif; other site 1322246001192 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 1322246001193 tRNA binding surface [nucleotide binding]; other site 1322246001194 anticodon binding site; other site 1322246001195 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1322246001196 TPR repeat; Region: TPR_11; pfam13414 1322246001197 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1322246001198 binding surface 1322246001199 TPR motif; other site 1322246001200 TPR repeat; Region: TPR_11; pfam13414 1322246001201 serine O-acetyltransferase; Region: cysE; TIGR01172 1322246001202 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1322246001203 trimer interface [polypeptide binding]; other site 1322246001204 active site 1322246001205 substrate binding site [chemical binding]; other site 1322246001206 CoA binding site [chemical binding]; other site 1322246001207 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1322246001208 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1322246001209 dimer interface [polypeptide binding]; other site 1322246001210 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1322246001211 catalytic residue [active] 1322246001212 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1322246001213 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1322246001214 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1322246001215 catalytic residue [active] 1322246001216 Fe-S cluster assembly protein NifU; Region: NifU_proper; TIGR02000 1322246001217 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1322246001218 trimerization site [polypeptide binding]; other site 1322246001219 active site 1322246001220 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1322246001221 NifU-like domain; Region: NifU; pfam01106 1322246001222 Protein of unknown function (DUF493); Region: DUF493; pfam04359 1322246001223 Response regulator receiver domain; Region: Response_reg; pfam00072 1322246001224 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1322246001225 active site 1322246001226 phosphorylation site [posttranslational modification] 1322246001227 intermolecular recognition site; other site 1322246001228 dimerization interface [polypeptide binding]; other site 1322246001229 PAS domain S-box; Region: sensory_box; TIGR00229 1322246001230 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1322246001231 putative active site [active] 1322246001232 heme pocket [chemical binding]; other site 1322246001233 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1322246001234 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1322246001235 metal binding site [ion binding]; metal-binding site 1322246001236 active site 1322246001237 I-site; other site 1322246001238 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1322246001239 This domain family includes the alpha-crystallin domain (ACD) of alpha-crystallin-type small heat shock proteins (sHsps) and a similar domain found in p23-like proteins. sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa; Region: ACD_sHsps_p23-like; cd00298 1322246001240 AAA domain; Region: AAA_32; pfam13654 1322246001241 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1322246001242 acetolactate synthase catalytic subunit; Validated; Region: PRK08155 1322246001243 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1322246001244 PYR/PP interface [polypeptide binding]; other site 1322246001245 dimer interface [polypeptide binding]; other site 1322246001246 TPP binding site [chemical binding]; other site 1322246001247 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1322246001248 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1322246001249 TPP-binding site [chemical binding]; other site 1322246001250 dimer interface [polypeptide binding]; other site 1322246001251 Acetolactate synthase, small (regulatory) subunit [Amino acid transport and metabolism]; Region: IlvH; COG0440 1322246001252 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 1322246001253 putative valine binding site [chemical binding]; other site 1322246001254 dimer interface [polypeptide binding]; other site 1322246001255 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 1322246001256 putative CheA interaction surface; other site 1322246001257 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 1322246001258 Smr domain; Region: Smr; pfam01713 1322246001259 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 1322246001260 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 1322246001261 Walker A/P-loop; other site 1322246001262 ATP binding site [chemical binding]; other site 1322246001263 Q-loop/lid; other site 1322246001264 ABC transporter signature motif; other site 1322246001265 Walker B; other site 1322246001266 D-loop; other site 1322246001267 H-loop/switch region; other site 1322246001268 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 1322246001269 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 1322246001270 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1322246001271 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1322246001272 Integrase core domain; Region: rve; pfam00665 1322246001273 Integrase core domain; Region: rve_3; pfam13683 1322246001274 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1322246001275 Transposase; Region: HTH_Tnp_1; pfam01527 1322246001276 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1322246001277 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1322246001278 Succinyl-CoA synthetase, beta subunit [Energy production and conversion]; Region: SucC; COG0045 1322246001279 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 1322246001280 CoA-ligase; Region: Ligase_CoA; pfam00549 1322246001281 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 1322246001282 CoA binding domain; Region: CoA_binding; smart00881 1322246001283 CoA-ligase; Region: Ligase_CoA; pfam00549 1322246001284 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 1322246001285 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 1322246001286 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 1322246001287 metal binding triad [ion binding]; metal-binding site 1322246001288 birA, biotin-[acetyl-CoA-carboxylase] ligase region; Region: birA_ligase; TIGR00121 1322246001289 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 1322246001290 pyruvate carboxylase; Reviewed; Region: PRK12999 1322246001291 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1322246001292 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1322246001293 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1322246001294 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 1322246001295 active site 1322246001296 catalytic residues [active] 1322246001297 metal binding site [ion binding]; metal-binding site 1322246001298 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1322246001299 carboxyltransferase (CT) interaction site; other site 1322246001300 biotinylation site [posttranslational modification]; other site 1322246001301 Double zinc ribbon; Region: DZR; pfam12773 1322246001302 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 1322246001303 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1322246001304 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 1322246001305 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1322246001306 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1322246001307 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1322246001308 FlaG protein; Region: FlaG; cl00591 1322246001309 Protein of unknown function (DUF342); Region: DUF342; pfam03961 1322246001310 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 1322246001311 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 1322246001312 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 1322246001313 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 1322246001314 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1322246001315 ligand binding site [chemical binding]; other site 1322246001316 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 1322246001317 flagellar motor protein MotS; Reviewed; Region: PRK06925 1322246001318 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1322246001319 ligand binding site [chemical binding]; other site 1322246001320 Cache domain; Region: Cache_1; pfam02743 1322246001321 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1322246001322 PAS fold; Region: PAS_3; pfam08447 1322246001323 putative active site [active] 1322246001324 heme pocket [chemical binding]; other site 1322246001325 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1322246001326 dimer interface [polypeptide binding]; other site 1322246001327 phosphorylation site [posttranslational modification] 1322246001328 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1322246001329 ATP binding site [chemical binding]; other site 1322246001330 Mg2+ binding site [ion binding]; other site 1322246001331 G-X-G motif; other site 1322246001332 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1322246001333 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1322246001334 active site 1322246001335 phosphorylation site [posttranslational modification] 1322246001336 intermolecular recognition site; other site 1322246001337 dimerization interface [polypeptide binding]; other site 1322246001338 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1322246001339 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 1322246001340 ligand binding site [chemical binding]; other site 1322246001341 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 1322246001342 Predicted permeases [General function prediction only]; Region: COG0795 1322246001343 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 1322246001344 Predicted permeases [General function prediction only]; Region: COG0795 1322246001345 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 1322246001346 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 1322246001347 G1 box; other site 1322246001348 GTP/Mg2+ binding site [chemical binding]; other site 1322246001349 Elongation factor Tu GTP binding domain; Region: GTP_EFTU; pfam00009 1322246001350 Switch I region; other site 1322246001351 G2 box; other site 1322246001352 G3 box; other site 1322246001353 Switch II region; other site 1322246001354 G4 box; other site 1322246001355 G5 box; other site 1322246001356 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 1322246001357 Dehydroquinase class II; Region: DHquinase_II; pfam01220 1322246001358 trimer interface [polypeptide binding]; other site 1322246001359 active site 1322246001360 dimer interface [polypeptide binding]; other site 1322246001361 elongation factor P; Validated; Region: PRK00529 1322246001362 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1322246001363 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1322246001364 RNA binding site [nucleotide binding]; other site 1322246001365 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1322246001366 RNA binding site [nucleotide binding]; other site 1322246001367 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 1322246001368 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1322246001369 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1322246001370 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 1322246001371 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 1322246001372 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 1322246001373 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1322246001374 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1322246001375 RNA binding surface [nucleotide binding]; other site 1322246001376 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 1322246001377 active site 1322246001378 selenium metabolism protein YedF; Region: selenium_YedF; TIGR03527 1322246001379 SirA_like_N, a protein of unknown function with an N-terminal SirA-like domain. The SirA, YedF, YeeD protein family is present in bacteria as well as archaea. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response...; Region: SirA_like_N; cd03421 1322246001380 CPxP motif; other site 1322246001381 DsrE/DsrF-like family; Region: DrsE; pfam02635 1322246001382 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: DUF374; Region: LPLAT_DUF374-like; cd07983 1322246001383 putative acyl-acceptor binding pocket; other site 1322246001384 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 1322246001385 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1322246001386 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1322246001387 isopentenyl-diphosphate delta-isomerase, type 1; Region: IPP_isom_1; TIGR02150 1322246001388 nudix motif; other site 1322246001389 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1322246001390 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1322246001391 Coenzyme A binding pocket [chemical binding]; other site 1322246001392 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 1322246001393 Phosphoglycerate kinase; Region: PGK; pfam00162 1322246001394 substrate binding site [chemical binding]; other site 1322246001395 hinge regions; other site 1322246001396 ADP binding site [chemical binding]; other site 1322246001397 catalytic site [active] 1322246001398 triosephosphate isomerase; Provisional; Region: PRK14565 1322246001399 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1322246001400 substrate binding site [chemical binding]; other site 1322246001401 dimer interface [polypeptide binding]; other site 1322246001402 catalytic triad [active] 1322246001403 Preprotein translocase SecG subunit; Region: SecG; pfam03840 1322246001404 Integrase core domain; Region: rve_3; pfam13683 1322246001405 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 1322246001406 AAA domain; Region: AAA_26; pfam13500 1322246001407 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 1322246001408 adenosylmethionine--8-amino-7-oxononanoate transaminase; Validated; Region: PRK07986 1322246001409 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1322246001410 inhibitor-cofactor binding pocket; inhibition site 1322246001411 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1322246001412 catalytic residue [active] 1322246001413 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1322246001414 Na binding site [ion binding]; other site 1322246001415 Transposase domain (DUF772); Region: DUF772; pfam05598 1322246001416 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1322246001417 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 1322246001418 MgtE intracellular N domain; Region: MgtE_N; pfam03448 1322246001419 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1322246001420 Divalent cation transporter; Region: MgtE; pfam01769 1322246001421 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 1322246001422 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 1322246001423 dimerization interface [polypeptide binding]; other site 1322246001424 active site 1322246001425 quinolinate synthetase; Provisional; Region: PRK09375 1322246001426 Aspartate oxidase [Coenzyme metabolism]; Region: NadB; COG0029 1322246001427 L-aspartate oxidase; Provisional; Region: PRK06175 1322246001428 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1322246001429 Cation transport protein; Region: TrkH; cl17365 1322246001430 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 1322246001431 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 1322246001432 TrkA-N domain; Region: TrkA_N; pfam02254 1322246001433 TrkA-C domain; Region: TrkA_C; pfam02080 1322246001434 TrkA-N domain; Region: TrkA_N; pfam02254 1322246001435 TrkA-C domain; Region: TrkA_C; pfam02080 1322246001436 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1322246001437 Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077 1322246001438 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1322246001439 Cupin domain; Region: Cupin_2; cl17218 1322246001440 Ferredoxin [Energy production and conversion]; Region: COG1146 1322246001441 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 1322246001442 4Fe-4S binding domain; Region: Fer4_5; pfam12801 1322246001443 Ferredoxin [Energy production and conversion]; Region: NapF; COG1145 1322246001444 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 1322246001445 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1322246001446 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1322246001447 ligand binding site [chemical binding]; other site 1322246001448 flexible hinge region; other site 1322246001449 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1322246001450 putative switch regulator; other site 1322246001451 non-specific DNA interactions [nucleotide binding]; other site 1322246001452 DNA binding site [nucleotide binding] 1322246001453 sequence specific DNA binding site [nucleotide binding]; other site 1322246001454 putative cAMP binding site [chemical binding]; other site 1322246001455 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 1322246001456 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 1322246001457 DALR anticodon binding domain; Region: DALR_1; pfam05746 1322246001458 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 1322246001459 dimer interface [polypeptide binding]; other site 1322246001460 motif 1; other site 1322246001461 active site 1322246001462 motif 2; other site 1322246001463 motif 3; other site 1322246001464 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 1322246001465 Recombination protein O N terminal; Region: RecO_N; pfam11967 1322246001466 Recombination protein O C terminal; Region: RecO_C; pfam02565 1322246001467 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 1322246001468 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1322246001469 non-specific DNA binding site [nucleotide binding]; other site 1322246001470 salt bridge; other site 1322246001471 sequence-specific DNA binding site [nucleotide binding]; other site 1322246001472 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 1322246001473 SurA N-terminal domain; Region: SurA_N; pfam09312 1322246001474 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 1322246001475 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 1322246001476 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 1322246001477 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 1322246001478 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 1322246001479 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1322246001480 ATP binding site [chemical binding]; other site 1322246001481 putative Mg++ binding site [ion binding]; other site 1322246001482 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1322246001483 nucleotide binding region [chemical binding]; other site 1322246001484 ATP-binding site [chemical binding]; other site 1322246001485 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 1322246001486 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 1322246001487 putative CheA interaction surface; other site 1322246001488 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1322246001489 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1322246001490 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1322246001491 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1322246001492 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 1322246001493 active site 1322246001494 hydrophilic channel; other site 1322246001495 dimerization interface [polypeptide binding]; other site 1322246001496 catalytic residues [active] 1322246001497 active site lid [active] 1322246001498 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK14657 1322246001499 putative carbohydrate kinase; Provisional; Region: PRK10565 1322246001500 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 1322246001501 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1322246001502 putative substrate binding site [chemical binding]; other site 1322246001503 putative ATP binding site [chemical binding]; other site 1322246001504 FOG: CBS domain [General function prediction only]; Region: COG0517 1322246001505 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1322246001506 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 1322246001507 aspartate kinase; Reviewed; Region: PRK06635 1322246001508 AAK_AK-DapG-like: Amino Acid Kinase Superfamily (AAK), AK-DapG-like; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the diaminopimelate-sensitive aspartokinase isoenzyme AKI (DapG), a monofunctional enzymes found in Bacilli; Region: AAK_AK-DapG-like; cd04246 1322246001509 putative catalytic residues [active] 1322246001510 putative nucleotide binding site [chemical binding]; other site 1322246001511 putative aspartate binding site [chemical binding]; other site 1322246001512 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 1322246001513 putative allosteric regulatory site; other site 1322246001514 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AK-LysC-DapG-like_2; cd04923 1322246001515 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 1322246001516 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 1322246001517 active site 1322246001518 catalytic residues [active] 1322246001519 metal binding site [ion binding]; metal-binding site 1322246001520 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 1322246001521 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 1322246001522 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 1322246001523 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1322246001524 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 1322246001525 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 1322246001526 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 1322246001527 generic binding surface II; other site 1322246001528 generic binding surface I; other site 1322246001529 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1322246001530 Zn2+ binding site [ion binding]; other site 1322246001531 Mg2+ binding site [ion binding]; other site 1322246001532 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1322246001533 thymidylate kinase; Validated; Region: tmk; PRK00698 1322246001534 TMP-binding site; other site 1322246001535 ATP-binding site [chemical binding]; other site 1322246001536 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1322246001537 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1322246001538 dimer interface [polypeptide binding]; other site 1322246001539 conserved gate region; other site 1322246001540 putative PBP binding loops; other site 1322246001541 ABC-ATPase subunit interface; other site 1322246001542 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1322246001543 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1322246001544 substrate binding pocket [chemical binding]; other site 1322246001545 membrane-bound complex binding site; other site 1322246001546 hinge residues; other site 1322246001547 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1322246001548 dimer interface [polypeptide binding]; other site 1322246001549 conserved gate region; other site 1322246001550 putative PBP binding loops; other site 1322246001551 ABC-ATPase subunit interface; other site 1322246001552 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 1322246001553 catalytic residues [active] 1322246001554 Ferredoxin thioredoxin reductase catalytic beta chain; Region: FeThRed_B; cl01977 1322246001555 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 1322246001556 ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067 1322246001557 ethanolamine ammonia-lyase small subunit; Provisional; Region: PRK05465 1322246001558 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 1322246001559 Protein export membrane protein; Region: SecD_SecF; pfam02355 1322246001560 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 1322246001561 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 1322246001562 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 1322246001563 Archaeal-type gltB domain. This domain shares sequence similarity with a region of unknown function found in the large subunit of glutamate synthase, which is encoded by gltB and found in most bacteria and eukaryotes. It is predicted to be homologous to...; Region: arch_gltB; cd00981 1322246001564 putative subunit interface; other site 1322246001565 Glutamate synthase domain 1 [Amino acid transport and metabolism]; Region: GltB; COG0067 1322246001566 Glutamine amidotransferases class-II (Gn-AT)_GlxB-type. GlxB is a glutamine amidotransferase-like protein of unknown function found in bacteria and archaea. GlxB has a structural fold similar to that of other class II glutamine amidotransferases...; Region: GlxB; cd01907 1322246001567 putative active site [active] 1322246001568 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 1322246001569 Conserved region in glutamate synthase; Region: Glu_synthase; pfam01645 1322246001570 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1322246001571 active site 1322246001572 FMN binding site [chemical binding]; other site 1322246001573 substrate binding site [chemical binding]; other site 1322246001574 3Fe-4S cluster binding site [ion binding]; other site 1322246001575 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1322246001576 trimer interface [polypeptide binding]; other site 1322246001577 active site 1322246001578 acetylornithine aminotransferase; Provisional; Region: PRK02627 1322246001579 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1322246001580 inhibitor-cofactor binding pocket; inhibition site 1322246001581 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1322246001582 catalytic residue [active] 1322246001583 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 1322246001584 Methyltransferase domain; Region: Methyltransf_18; pfam12847 1322246001585 Uncharacterized protein related to Endonuclease III [DNA replication, recombination, and repair]; Region: COG2231 1322246001586 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1322246001587 minor groove reading motif; other site 1322246001588 helix-hairpin-helix signature motif; other site 1322246001589 substrate binding pocket [chemical binding]; other site 1322246001590 active site 1322246001591 Peptidase family M23; Region: Peptidase_M23; pfam01551 1322246001592 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 1322246001593 C-terminal peptidase (prc); Region: prc; TIGR00225 1322246001594 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1322246001595 protein binding site [polypeptide binding]; other site 1322246001596 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 1322246001597 Catalytic dyad [active] 1322246001598 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 1322246001599 NodB motif; other site 1322246001600 putative active site [active] 1322246001601 putative catalytic site [active] 1322246001602 Zn binding site [ion binding]; other site 1322246001603 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 1322246001604 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 1322246001605 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 1322246001606 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 1322246001607 zinc binding site [ion binding]; other site 1322246001608 putative ligand binding site [chemical binding]; other site 1322246001609 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1322246001610 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 1322246001611 TM-ABC transporter signature motif; other site 1322246001612 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 1322246001613 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1322246001614 Walker A/P-loop; other site 1322246001615 ATP binding site [chemical binding]; other site 1322246001616 Q-loop/lid; other site 1322246001617 ABC transporter signature motif; other site 1322246001618 Walker B; other site 1322246001619 D-loop; other site 1322246001620 H-loop/switch region; other site 1322246001621 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 1322246001622 active site 1322246001623 multimer interface [polypeptide binding]; other site 1322246001624 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 1322246001625 pyrroline-5-carboxylate reductase; Region: PLN02688 1322246001626 CobD/Cbib protein; Region: CobD_Cbib; pfam03186 1322246001627 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 1322246001628 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 1322246001629 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1322246001630 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1322246001631 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1322246001632 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1322246001633 DNA binding residues [nucleotide binding] 1322246001634 DNA primase; Validated; Region: dnaG; PRK05667 1322246001635 CHC2 zinc finger; Region: zf-CHC2; cl17510 1322246001636 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1322246001637 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1322246001638 active site 1322246001639 metal binding site [ion binding]; metal-binding site 1322246001640 interdomain interaction site; other site 1322246001641 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 1322246001642 MutS domain III; Region: MutS_III; pfam05192 1322246001643 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1322246001644 Walker A/P-loop; other site 1322246001645 ATP binding site [chemical binding]; other site 1322246001646 Q-loop/lid; other site 1322246001647 ABC transporter signature motif; other site 1322246001648 Walker B; other site 1322246001649 D-loop; other site 1322246001650 H-loop/switch region; other site 1322246001651 Smr domain; Region: Smr; pfam01713 1322246001652 Yqey-like protein; Region: YqeY; pfam09424 1322246001653 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 1322246001654 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1322246001655 IHF dimer interface [polypeptide binding]; other site 1322246001656 IHF - DNA interface [nucleotide binding]; other site 1322246001657 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1322246001658 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 1322246001659 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1322246001660 active site 1322246001661 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 1322246001662 N-ethylammeline chlorohydrolase; Provisional; Region: PRK09045 1322246001663 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 1322246001664 active site 1322246001665 putative substrate binding pocket [chemical binding]; other site 1322246001666 diaminopimelate aminotransferase; Provisional; Region: PRK13983 1322246001667 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like1; cd05650 1322246001668 metal binding site [ion binding]; metal-binding site 1322246001669 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 1322246001670 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 1322246001671 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 1322246001672 Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535 1322246001673 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1322246001674 Transporter associated domain; Region: CorC_HlyC; smart01091 1322246001675 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 1322246001676 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 1322246001677 putative active site [active] 1322246001678 catalytic triad [active] 1322246001679 putative dimer interface [polypeptide binding]; other site 1322246001680 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1322246001681 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 1322246001682 RF-1 domain; Region: RF-1; pfam00472 1322246001683 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1322246001684 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1322246001685 metal binding site [ion binding]; metal-binding site 1322246001686 active site 1322246001687 I-site; other site 1322246001688 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 1322246001689 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1322246001690 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 1322246001691 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1322246001692 IHF - DNA interface [nucleotide binding]; other site 1322246001693 IHF dimer interface [polypeptide binding]; other site 1322246001694 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1322246001695 dihydrodipicolinate synthase; Region: dapA; TIGR00674 1322246001696 dimer interface [polypeptide binding]; other site 1322246001697 active site 1322246001698 catalytic residue [active] 1322246001699 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 1322246001700 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1322246001701 DHHA2 domain; Region: DHHA2; pfam02833 1322246001702 PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830 1322246001703 active site 1322246001704 phosphorylation site [posttranslational modification] 1322246001705 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1322246001706 active pocket/dimerization site; other site 1322246001707 active site 1322246001708 phosphorylation site [posttranslational modification] 1322246001709 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 1322246001710 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1322246001711 active site 1322246001712 phosphorylation site [posttranslational modification] 1322246001713 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1322246001714 30S subunit binding site; other site 1322246001715 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 1322246001716 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 1322246001717 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 1322246001718 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 1322246001719 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 1322246001720 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 1322246001721 Walker A/P-loop; other site 1322246001722 ATP binding site [chemical binding]; other site 1322246001723 Q-loop/lid; other site 1322246001724 ABC transporter signature motif; other site 1322246001725 Walker B; other site 1322246001726 D-loop; other site 1322246001727 H-loop/switch region; other site 1322246001728 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 1322246001729 OstA-like protein; Region: OstA; pfam03968 1322246001730 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117; cl01200 1322246001731 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1322246001732 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1322246001733 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 1322246001734 CTP synthetase; Validated; Region: pyrG; PRK05380 1322246001735 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1322246001736 Catalytic site [active] 1322246001737 active site 1322246001738 UTP binding site [chemical binding]; other site 1322246001739 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1322246001740 active site 1322246001741 putative oxyanion hole; other site 1322246001742 catalytic triad [active] 1322246001743 CobB/CobQ-like glutamine amidotransferase domain; Region: GATase_5; pfam13507 1322246001744 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1322246001745 conserved cys residue [active] 1322246001746 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1322246001747 nucleoside/Zn binding site; other site 1322246001748 dimer interface [polypeptide binding]; other site 1322246001749 catalytic motif [active] 1322246001750 This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851 1322246001751 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1322246001752 active site 1322246001753 DNA binding site [nucleotide binding] 1322246001754 Int/Topo IB signature motif; other site 1322246001755 Peptidase family S49; Region: Peptidase_S49; pfam01343 1322246001756 Integrase core domain; Region: rve; pfam00665 1322246001757 Integrase core domain; Region: rve_3; cl15866 1322246001758 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1322246001759 Transposase; Region: HTH_Tnp_1; pfam01527 1322246001760 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1322246001761 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 1322246001762 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 1322246001763 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1322246001764 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1322246001765 DNA binding residues [nucleotide binding] 1322246001766 Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712 1322246001767 FecR protein; Region: FecR; pfam04773 1322246001768 Secretin and TonB N terminus short domain; Region: STN; smart00965 1322246001769 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1322246001770 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1322246001771 N-terminal plug; other site 1322246001772 ligand-binding site [chemical binding]; other site 1322246001773 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 1322246001774 PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706 1322246001775 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1322246001776 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 1322246001777 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1322246001778 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1322246001779 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1322246001780 putative substrate translocation pore; other site 1322246001781 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 1322246001782 ApbE family; Region: ApbE; pfam02424 1322246001783 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 1322246001784 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1322246001785 dimer interface [polypeptide binding]; other site 1322246001786 phosphorylation site [posttranslational modification] 1322246001787 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1322246001788 ATP binding site [chemical binding]; other site 1322246001789 Mg2+ binding site [ion binding]; other site 1322246001790 G-X-G motif; other site 1322246001791 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1322246001792 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1322246001793 active site 1322246001794 phosphorylation site [posttranslational modification] 1322246001795 intermolecular recognition site; other site 1322246001796 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 1322246001797 dimerization interface [polypeptide binding]; other site 1322246001798 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1322246001799 Walker A motif; other site 1322246001800 ATP binding site [chemical binding]; other site 1322246001801 Walker B motif; other site 1322246001802 arginine finger; other site 1322246001803 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 1322246001804 Quinol:fumarate reductase (QFR) Type B subfamily, transmembrane subunit; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinone...; Region: QFR_TypeB_TM; cd00581 1322246001805 Iron-sulfur protein interface; other site 1322246001806 proximal heme binding site [chemical binding]; other site 1322246001807 distal heme binding site [chemical binding]; other site 1322246001808 dimer interface [polypeptide binding]; other site 1322246001809 fumarate reductase flavoprotein subunit; Provisional; Region: PRK08626 1322246001810 L-aspartate oxidase; Provisional; Region: PRK06175 1322246001811 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1322246001812 fumarate reductase iron-sulfur subunit; Provisional; Region: frdB; PRK13552 1322246001813 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1322246001814 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1322246001815 fumarate hydratase; Provisional; Region: PRK06246 1322246001816 Fumarase C-terminus; Region: Fumerase_C; cl00795 1322246001817 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 1322246001818 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1322246001819 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 1322246001820 putative NAD(P) binding site [chemical binding]; other site 1322246001821 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1322246001822 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 1322246001823 transmembrane helices; other site 1322246001824 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1322246001825 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 1322246001826 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; cl00779 1322246001827 FMN-binding domain; Region: FMN_bind; cl01081 1322246001828 electron transport complex RsxE subunit; Provisional; Region: PRK12405 1322246001829 Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597 1322246001830 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 1322246001831 4Fe-4S binding domain; Region: Fer4; pfam00037 1322246001832 putative oxidoreductase; Provisional; Region: PRK12831 1322246001833 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1322246001834 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1322246001835 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 1322246001836 propionate/acetate kinase; Provisional; Region: PRK12379 1322246001837 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 1322246001838 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 1322246001839 dimer interface [polypeptide binding]; other site 1322246001840 PYR/PP interface [polypeptide binding]; other site 1322246001841 TPP binding site [chemical binding]; other site 1322246001842 substrate binding site [chemical binding]; other site 1322246001843 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 1322246001844 Domain of unknown function; Region: EKR; pfam10371 1322246001845 4Fe-4S binding domain; Region: Fer4_6; pfam12837 1322246001846 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1322246001847 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 1322246001848 TPP-binding site [chemical binding]; other site 1322246001849 dimer interface [polypeptide binding]; other site 1322246001850 Bacterial OB fold (BOF) protein; Region: BOF; cl01196 1322246001851 Nickel-containing superoxide dismutase; Region: Sod_Ni; pfam09055 1322246001852 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 1322246001853 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1322246001854 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 1322246001855 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1322246001856 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1322246001857 Walker A/P-loop; other site 1322246001858 ATP binding site [chemical binding]; other site 1322246001859 Q-loop/lid; other site 1322246001860 ABC transporter signature motif; other site 1322246001861 Walker B; other site 1322246001862 D-loop; other site 1322246001863 H-loop/switch region; other site 1322246001864 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1322246001865 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1322246001866 substrate binding pocket [chemical binding]; other site 1322246001867 membrane-bound complex binding site; other site 1322246001868 hinge residues; other site 1322246001869 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1322246001870 dimer interface [polypeptide binding]; other site 1322246001871 conserved gate region; other site 1322246001872 putative PBP binding loops; other site 1322246001873 ABC-ATPase subunit interface; other site 1322246001874 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1322246001875 dimer interface [polypeptide binding]; other site 1322246001876 conserved gate region; other site 1322246001877 putative PBP binding loops; other site 1322246001878 ABC-ATPase subunit interface; other site 1322246001879 2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537 1322246001880 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 1322246001881 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 1322246001882 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 1322246001883 TPP-binding site [chemical binding]; other site 1322246001884 2-oxoglutarate ferredoxin oxidoreductase subunit alpha; Validated; Region: PRK08659 1322246001885 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 1322246001886 dimer interface [polypeptide binding]; other site 1322246001887 PYR/PP interface [polypeptide binding]; other site 1322246001888 TPP binding site [chemical binding]; other site 1322246001889 substrate binding site [chemical binding]; other site 1322246001890 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 1322246001891 Ferredoxin [Energy production and conversion]; Region: COG1146 1322246001892 cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; cl00913 1322246001893 Precorrin-8X methylmutase; Region: CbiC; pfam02570 1322246001894 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 1322246001895 intersubunit interface [polypeptide binding]; other site 1322246001896 active site 1322246001897 catalytic residue [active] 1322246001898 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1322246001899 dimer interface [polypeptide binding]; other site 1322246001900 conserved gate region; other site 1322246001901 putative PBP binding loops; other site 1322246001902 ABC-ATPase subunit interface; other site 1322246001903 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1322246001904 dimer interface [polypeptide binding]; other site 1322246001905 conserved gate region; other site 1322246001906 putative PBP binding loops; other site 1322246001907 ABC-ATPase subunit interface; other site 1322246001908 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1322246001909 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1322246001910 substrate binding pocket [chemical binding]; other site 1322246001911 membrane-bound complex binding site; other site 1322246001912 hinge residues; other site 1322246001913 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1322246001914 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1322246001915 Walker A/P-loop; other site 1322246001916 ATP binding site [chemical binding]; other site 1322246001917 Q-loop/lid; other site 1322246001918 ABC transporter signature motif; other site 1322246001919 Walker B; other site 1322246001920 D-loop; other site 1322246001921 H-loop/switch region; other site 1322246001922 Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901 1322246001923 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 1322246001924 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 1322246001925 4Fe-4S binding domain; Region: Fer4; cl02805 1322246001926 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1322246001927 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 1322246001928 molybdopterin cofactor binding site; other site 1322246001929 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cd02775 1322246001930 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 1322246001931 heme-binding residues [chemical binding]; other site 1322246001932 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 1322246001933 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 1322246001934 Substrate binding site; other site 1322246001935 Cupin domain; Region: Cupin_2; cl17218 1322246001936 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 1322246001937 Colicin V production protein; Region: Colicin_V; pfam02674 1322246001938 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 1322246001939 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 1322246001940 homodimer interface [polypeptide binding]; other site 1322246001941 metal binding site [ion binding]; metal-binding site 1322246001942 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 1322246001943 homodimer interface [polypeptide binding]; other site 1322246001944 active site 1322246001945 putative chemical substrate binding site [chemical binding]; other site 1322246001946 metal binding site [ion binding]; metal-binding site 1322246001947 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 1322246001948 active site 1322246001949 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1322246001950 active site 1322246001951 ATP binding site [chemical binding]; other site 1322246001952 substrate binding site [chemical binding]; other site 1322246001953 activation loop (A-loop); other site 1322246001954 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495 1322246001955 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1322246001956 active site 1322246001957 DNA binding site [nucleotide binding] 1322246001958 Int/Topo IB signature motif; other site 1322246001959 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 1322246001960 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1322246001961 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1322246001962 P-loop; other site 1322246001963 Magnesium ion binding site [ion binding]; other site 1322246001964 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 1322246001965 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 1322246001966 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1322246001967 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1322246001968 catalytic residues [active] 1322246001969 catalytic nucleophile [active] 1322246001970 Presynaptic Site I dimer interface [polypeptide binding]; other site 1322246001971 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1322246001972 Synaptic Flat tetramer interface [polypeptide binding]; other site 1322246001973 Synaptic Site I dimer interface [polypeptide binding]; other site 1322246001974 DNA binding site [nucleotide binding] 1322246001975 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 1322246001976 DNA-binding interface [nucleotide binding]; DNA binding site 1322246001977 Short C-terminal domain; Region: SHOCT; pfam09851 1322246001978 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cl01482 1322246001979 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1322246001980 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1322246001981 putative active site [active] 1322246001982 heme pocket [chemical binding]; other site 1322246001983 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1322246001984 dimer interface [polypeptide binding]; other site 1322246001985 phosphorylation site [posttranslational modification] 1322246001986 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1322246001987 ATP binding site [chemical binding]; other site 1322246001988 Mg2+ binding site [ion binding]; other site 1322246001989 G-X-G motif; other site 1322246001990 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1322246001991 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1322246001992 active site 1322246001993 phosphorylation site [posttranslational modification] 1322246001994 intermolecular recognition site; other site 1322246001995 dimerization interface [polypeptide binding]; other site 1322246001996 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1322246001997 Walker A motif; other site 1322246001998 ATP binding site [chemical binding]; other site 1322246001999 Walker B motif; other site 1322246002000 arginine finger; other site 1322246002001 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1322246002002 conjugal transfer/type IV secretion protein DotA/TraY; Region: DotA_TraY; TIGR04346 1322246002003 Helix-turn-helix domain; Region: HTH_36; pfam13730 1322246002004 integrase; Provisional; Region: PRK09692 1322246002005 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 1322246002006 active site 1322246002007 Int/Topo IB signature motif; other site 1322246002008 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1322246002009 metal binding site 2 [ion binding]; metal-binding site 1322246002010 putative DNA binding helix; other site 1322246002011 metal binding site 1 [ion binding]; metal-binding site 1322246002012 dimer interface [polypeptide binding]; other site 1322246002013 structural Zn2+ binding site [ion binding]; other site 1322246002014 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 1322246002015 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1322246002016 Cysteine-rich domain; Region: CCG; pfam02754 1322246002017 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 1322246002018 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH2; cd08183 1322246002019 putative active site [active] 1322246002020 metal binding site [ion binding]; metal-binding site 1322246002021 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1322246002022 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 1322246002023 glycerol kinase; Provisional; Region: glpK; PRK00047 1322246002024 Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789 1322246002025 N- and C-terminal domain interface [polypeptide binding]; other site 1322246002026 active site 1322246002027 MgATP binding site [chemical binding]; other site 1322246002028 catalytic site [active] 1322246002029 metal binding site [ion binding]; metal-binding site 1322246002030 putative homotetramer interface [polypeptide binding]; other site 1322246002031 glycerol binding site [chemical binding]; other site 1322246002032 homodimer interface [polypeptide binding]; other site 1322246002033 Heterodisulfide reductase, subunit B [Energy production and conversion]; Region: HdrB; COG2048 1322246002034 Cysteine-rich domain; Region: CCG; pfam02754 1322246002035 Cysteine-rich domain; Region: CCG; pfam02754 1322246002036 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959 1322246002037 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 1322246002038 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 1322246002039 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 1322246002040 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 1322246002041 anaerobic glycerol-3-phosphate dehydrogenase subunit B; Validated; Region: PRK05329 1322246002042 glycerol-3-phosphate dehydrogenase, anaerobic, A subunit; Region: glycerol3P_GlpA; TIGR03377 1322246002043 DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906 1322246002044 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1322246002045 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1322246002046 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 1322246002047 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 1322246002048 Walker A/P-loop; other site 1322246002049 ATP binding site [chemical binding]; other site 1322246002050 Q-loop/lid; other site 1322246002051 ABC transporter signature motif; other site 1322246002052 Walker B; other site 1322246002053 D-loop; other site 1322246002054 H-loop/switch region; other site 1322246002055 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 1322246002056 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 1322246002057 Walker A/P-loop; other site 1322246002058 ATP binding site [chemical binding]; other site 1322246002059 Q-loop/lid; other site 1322246002060 ABC transporter signature motif; other site 1322246002061 Walker B; other site 1322246002062 D-loop; other site 1322246002063 H-loop/switch region; other site 1322246002064 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1322246002065 dimer interface [polypeptide binding]; other site 1322246002066 conserved gate region; other site 1322246002067 putative PBP binding loops; other site 1322246002068 ABC-ATPase subunit interface; other site 1322246002069 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1322246002070 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1322246002071 dimer interface [polypeptide binding]; other site 1322246002072 conserved gate region; other site 1322246002073 ABC-ATPase subunit interface; other site 1322246002074 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1322246002075 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1322246002076 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1322246002077 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 1322246002078 ligand binding site [chemical binding]; other site 1322246002079 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1322246002080 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1322246002081 ATP binding site [chemical binding]; other site 1322246002082 Mg2+ binding site [ion binding]; other site 1322246002083 G-X-G motif; other site 1322246002084 Response regulator receiver domain; Region: Response_reg; pfam00072 1322246002085 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1322246002086 active site 1322246002087 phosphorylation site [posttranslational modification] 1322246002088 intermolecular recognition site; other site 1322246002089 dimerization interface [polypeptide binding]; other site 1322246002090 HDOD domain; Region: HDOD; pfam08668 1322246002091 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1322246002092 Zn2+ binding site [ion binding]; other site 1322246002093 Mg2+ binding site [ion binding]; other site 1322246002094 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 1322246002095 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1322246002096 active site 1322246002097 phosphorylation site [posttranslational modification] 1322246002098 intermolecular recognition site; other site 1322246002099 dimerization interface [polypeptide binding]; other site 1322246002100 HD domain; Region: HD_5; pfam13487 1322246002101 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1322246002102 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1322246002103 putative active site [active] 1322246002104 heme pocket [chemical binding]; other site 1322246002105 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1322246002106 putative active site [active] 1322246002107 heme pocket [chemical binding]; other site 1322246002108 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1322246002109 PAS domain; Region: PAS_9; pfam13426 1322246002110 putative active site [active] 1322246002111 heme pocket [chemical binding]; other site 1322246002112 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1322246002113 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1322246002114 ATP binding site [chemical binding]; other site 1322246002115 Mg2+ binding site [ion binding]; other site 1322246002116 G-X-G motif; other site 1322246002117 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1322246002118 active site 1322246002119 putative phosphonate metabolism protein; Region: Phn_opern_protn; TIGR03223 1322246002120 phosphonates metabolism transcriptional regulator PhnF; Region: C_P_lyase_phnF; TIGR02325 1322246002121 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1322246002122 DNA-binding site [nucleotide binding]; DNA binding site 1322246002123 UTRA domain; Region: UTRA; pfam07702 1322246002124 Phosphonate metabolism protein PhnG; Region: PhnG; pfam06754 1322246002125 Bacterial phosphonate metabolism protein (PhnH); Region: PhnH; pfam05845 1322246002126 Bacterial phosphonate metabolism protein (PhnI); Region: PhnI; pfam05861 1322246002127 Phosphonate metabolism protein PhnJ; Region: PhnJ; pfam06007 1322246002128 phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701 1322246002129 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1322246002130 Walker A/P-loop; other site 1322246002131 ATP binding site [chemical binding]; other site 1322246002132 Q-loop/lid; other site 1322246002133 ABC transporter signature motif; other site 1322246002134 Walker B; other site 1322246002135 D-loop; other site 1322246002136 H-loop/switch region; other site 1322246002137 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1322246002138 ABC-type phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PhnL; COG4778 1322246002139 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1322246002140 Walker A/P-loop; other site 1322246002141 ATP binding site [chemical binding]; other site 1322246002142 Q-loop/lid; other site 1322246002143 ABC transporter signature motif; other site 1322246002144 Walker B; other site 1322246002145 D-loop; other site 1322246002146 H-loop/switch region; other site 1322246002147 phosphonate metabolism protein PhnM; Provisional; Region: PRK15446 1322246002148 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1322246002149 PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306 1322246002150 active site 1322246002151 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 1322246002152 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 1322246002153 Walker A/P-loop; other site 1322246002154 ATP binding site [chemical binding]; other site 1322246002155 Q-loop/lid; other site 1322246002156 ABC transporter signature motif; other site 1322246002157 Walker B; other site 1322246002158 D-loop; other site 1322246002159 H-loop/switch region; other site 1322246002160 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 1322246002161 phosphonate ABC transporter, periplasmic phosphonate binding protein; Region: PhnD; TIGR03431 1322246002162 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1322246002163 substrate binding pocket [chemical binding]; other site 1322246002164 membrane-bound complex binding site; other site 1322246002165 hinge residues; other site 1322246002166 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 1322246002167 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1322246002168 dimer interface [polypeptide binding]; other site 1322246002169 conserved gate region; other site 1322246002170 putative PBP binding loops; other site 1322246002171 ABC-ATPase subunit interface; other site 1322246002172 benzoyl-CoA reductase, subunit C; Region: benz_CoA_red_C; TIGR02263 1322246002173 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 1322246002174 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 1322246002175 arginine decarboxylase; Provisional; Region: PRK05354 1322246002176 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 1322246002177 active site 1322246002178 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1322246002179 catalytic residues [active] 1322246002180 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1322246002181 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 1322246002182 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1322246002183 carboxynorspermidine decarboxylase; Region: nspC; TIGR01047 1322246002184 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829 1322246002185 dimer interface [polypeptide binding]; other site 1322246002186 active site 1322246002187 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1322246002188 catalytic residues [active] 1322246002189 substrate binding site [chemical binding]; other site 1322246002190 agmatinase; Region: agmatinase; TIGR01230 1322246002191 Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593 1322246002192 putative active site [active] 1322246002193 Mn binding site [ion binding]; other site 1322246002194 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1322246002195 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1322246002196 dimer interface [polypeptide binding]; other site 1322246002197 phosphorylation site [posttranslational modification] 1322246002198 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1322246002199 ATP binding site [chemical binding]; other site 1322246002200 Mg2+ binding site [ion binding]; other site 1322246002201 G-X-G motif; other site 1322246002202 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1322246002203 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1322246002204 active site 1322246002205 phosphorylation site [posttranslational modification] 1322246002206 intermolecular recognition site; other site 1322246002207 dimerization interface [polypeptide binding]; other site 1322246002208 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1322246002209 Walker A motif; other site 1322246002210 ATP binding site [chemical binding]; other site 1322246002211 Walker B motif; other site 1322246002212 arginine finger; other site 1322246002213 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1322246002214 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1322246002215 Response regulator receiver domain; Region: Response_reg; pfam00072 1322246002216 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1322246002217 active site 1322246002218 phosphorylation site [posttranslational modification] 1322246002219 intermolecular recognition site; other site 1322246002220 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1322246002221 dimer interface [polypeptide binding]; other site 1322246002222 phosphorylation site [posttranslational modification] 1322246002223 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1322246002224 ATP binding site [chemical binding]; other site 1322246002225 Mg2+ binding site [ion binding]; other site 1322246002226 G-X-G motif; other site 1322246002227 Response regulator receiver domain; Region: Response_reg; pfam00072 1322246002228 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1322246002229 active site 1322246002230 phosphorylation site [posttranslational modification] 1322246002231 intermolecular recognition site; other site 1322246002232 dimerization interface [polypeptide binding]; other site 1322246002233 Response regulator receiver domain; Region: Response_reg; pfam00072 1322246002234 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1322246002235 active site 1322246002236 phosphorylation site [posttranslational modification] 1322246002237 intermolecular recognition site; other site 1322246002238 dimerization interface [polypeptide binding]; other site 1322246002239 Response regulator receiver domain; Region: Response_reg; pfam00072 1322246002240 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1322246002241 active site 1322246002242 phosphorylation site [posttranslational modification] 1322246002243 intermolecular recognition site; other site 1322246002244 dimerization interface [polypeptide binding]; other site 1322246002245 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1322246002246 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1322246002247 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl17700 1322246002248 Methyltransferase domain; Region: Methyltransf_12; pfam08242 1322246002249 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 1322246002250 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1322246002251 catalytic center binding site [active] 1322246002252 ATP binding site [chemical binding]; other site 1322246002253 LL-diaminopimelate aminotransferase; Provisional; Region: PRK09276 1322246002254 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1322246002255 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1322246002256 homodimer interface [polypeptide binding]; other site 1322246002257 catalytic residue [active] 1322246002258 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 1322246002259 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 1322246002260 active site 1322246002261 Int/Topo IB signature motif; other site 1322246002262 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 1322246002263 DHH family; Region: DHH; pfam01368 1322246002264 DHHA1 domain; Region: DHHA1; pfam02272 1322246002265 FOG: CBS domain [General function prediction only]; Region: COG0517 1322246002266 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with an upstream DHH domain which performs a phosphoesterase function and a downstream polyA polymerase domain. CBS is a small domain originally...; Region: CBS_pair_DHH_polyA_Pol_assoc; cd04595 1322246002267 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1322246002268 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 1322246002269 active site 1322246002270 NTP binding site [chemical binding]; other site 1322246002271 metal binding triad [ion binding]; metal-binding site 1322246002272 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 1322246002273 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 1322246002274 nucleotide binding site/active site [active] 1322246002275 HIT family signature motif; other site 1322246002276 catalytic residue [active] 1322246002277 Protein of unknown function (DUF1049); Region: DUF1049; cl01539 1322246002278 tetratricopeptide repeat protein; Provisional; Region: PRK11788 1322246002279 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 1322246002280 MutS domain I; Region: MutS_I; pfam01624 1322246002281 MutS domain II; Region: MutS_II; pfam05188 1322246002282 MutS domain III; Region: MutS_III; pfam05192 1322246002283 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 1322246002284 Walker A/P-loop; other site 1322246002285 ATP binding site [chemical binding]; other site 1322246002286 Q-loop/lid; other site 1322246002287 ABC transporter signature motif; other site 1322246002288 Walker B; other site 1322246002289 D-loop; other site 1322246002290 H-loop/switch region; other site 1322246002291 diaminopimelate decarboxylase; Region: lysA; TIGR01048 1322246002292 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1322246002293 active site 1322246002294 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1322246002295 substrate binding site [chemical binding]; other site 1322246002296 catalytic residues [active] 1322246002297 dimer interface [polypeptide binding]; other site 1322246002298 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 1322246002299 recombination factor protein RarA; Reviewed; Region: PRK13342 1322246002300 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1322246002301 Walker A motif; other site 1322246002302 ATP binding site [chemical binding]; other site 1322246002303 Walker B motif; other site 1322246002304 arginine finger; other site 1322246002305 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1322246002306 DUF based on E. rectale Gene description (DUF3880); Region: DUF3880; pfam12996 1322246002307 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 1322246002308 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1322246002309 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1322246002310 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 1322246002311 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 1322246002312 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 1322246002313 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 1322246002314 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 1322246002315 tRNA; other site 1322246002316 putative tRNA binding site [nucleotide binding]; other site 1322246002317 putative NADP binding site [chemical binding]; other site 1322246002318 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 1322246002319 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 1322246002320 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1322246002321 Ligand Binding Site [chemical binding]; other site 1322246002322 adenylate kinase; Provisional; Region: PRK14529 1322246002323 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1322246002324 AMP-binding site [chemical binding]; other site 1322246002325 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1322246002326 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1322246002327 EamA-like transporter family; Region: EamA; pfam00892 1322246002328 EamA-like transporter family; Region: EamA; pfam00892 1322246002329 Protein of unknown function (DUF1499); Region: DUF1499; cl01841 1322246002330 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 1322246002331 4Fe-4S single cluster domain; Region: Fer4_13; pfam13370 1322246002332 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1322246002333 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1322246002334 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1322246002335 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1322246002336 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1322246002337 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; pfam03255 1322246002338 Acetyl-CoA carboxylase beta subunit [Lipid metabolism]; Region: AccD; COG0777 1322246002339 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1322246002340 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1322246002341 active site residue [active] 1322246002342 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 1322246002343 active site 1322246002344 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 1322246002345 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 1322246002346 active site 1322246002347 Int/Topo IB signature motif; other site 1322246002348 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1322246002349 active site 1322246002350 phosphorylation site [posttranslational modification] 1322246002351 intermolecular recognition site; other site 1322246002352 dimerization interface [polypeptide binding]; other site 1322246002353 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1322246002354 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1322246002355 metal binding site [ion binding]; metal-binding site 1322246002356 active site 1322246002357 I-site; other site 1322246002358 HDOD domain; Region: HDOD; pfam08668 1322246002359 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1322246002360 Zn2+ binding site [ion binding]; other site 1322246002361 Mg2+ binding site [ion binding]; other site 1322246002362 Predicted membrane protein [Function unknown]; Region: COG2119 1322246002363 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 1322246002364 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 1322246002365 DNA protecting protein DprA; Region: dprA; TIGR00732 1322246002366 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 1322246002367 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1322246002368 binding surface 1322246002369 TPR motif; other site 1322246002370 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1322246002371 putative binding surface; other site 1322246002372 active site 1322246002373 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1322246002374 putative binding surface; other site 1322246002375 active site 1322246002376 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 1322246002377 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 1322246002378 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1322246002379 ATP binding site [chemical binding]; other site 1322246002380 Mg2+ binding site [ion binding]; other site 1322246002381 G-X-G motif; other site 1322246002382 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 1322246002383 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1322246002384 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1322246002385 active site 1322246002386 phosphorylation site [posttranslational modification] 1322246002387 intermolecular recognition site; other site 1322246002388 dimerization interface [polypeptide binding]; other site 1322246002389 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 1322246002390 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 1322246002391 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 1322246002392 HEAT repeats; Region: HEAT_2; pfam13646 1322246002393 HEAT repeats; Region: HEAT_2; pfam13646 1322246002394 HEAT repeats; Region: HEAT_2; pfam13646 1322246002395 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 1322246002396 HEAT repeats; Region: HEAT_2; pfam13646 1322246002397 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 1322246002398 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1322246002399 active site 1322246002400 phosphorylation site [posttranslational modification] 1322246002401 intermolecular recognition site; other site 1322246002402 dimerization interface [polypeptide binding]; other site 1322246002403 CheB methylesterase; Region: CheB_methylest; pfam01339 1322246002404 GTP-binding protein Der; Reviewed; Region: PRK00093 1322246002405 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1322246002406 G1 box; other site 1322246002407 GTP/Mg2+ binding site [chemical binding]; other site 1322246002408 Switch I region; other site 1322246002409 G2 box; other site 1322246002410 Switch II region; other site 1322246002411 G3 box; other site 1322246002412 G4 box; other site 1322246002413 G5 box; other site 1322246002414 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1322246002415 G1 box; other site 1322246002416 GTP/Mg2+ binding site [chemical binding]; other site 1322246002417 Switch I region; other site 1322246002418 G2 box; other site 1322246002419 G3 box; other site 1322246002420 Switch II region; other site 1322246002421 G4 box; other site 1322246002422 G5 box; other site 1322246002423 Cache domain; Region: Cache_1; pfam02743 1322246002424 HAMP domain; Region: HAMP; pfam00672 1322246002425 PAS domain; Region: PAS_9; pfam13426 1322246002426 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1322246002427 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1322246002428 dimer interface [polypeptide binding]; other site 1322246002429 putative CheW interface [polypeptide binding]; other site 1322246002430 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348 1322246002431 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 1322246002432 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 1322246002433 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 1322246002434 GatB domain; Region: GatB_Yqey; smart00845 1322246002435 Protein of unknown function (DUF4254); Region: DUF4254; pfam14063 1322246002436 MltA specific insert domain; Region: MltA; smart00925 1322246002437 3D domain; Region: 3D; pfam06725 1322246002438 Protein of unknown function DUF89; Region: DUF89; cl15397 1322246002439 NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061 1322246002440 ATP-NAD kinase; Region: NAD_kinase; pfam01513 1322246002441 Anti-sigma-28 factor, FlgM; Region: FlgM; pfam04316 1322246002442 flagellar assembly protein FliW; Provisional; Region: PRK13285 1322246002443 Global regulator protein family; Region: CsrA; pfam02599 1322246002444 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1322246002445 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK07701 1322246002446 flagellar hook-associated protein FlgK; Region: flgK_ends; TIGR02492 1322246002447 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK08471 1322246002448 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1322246002449 FlgN protein; Region: FlgN; pfam05130 1322246002450 Rod binding protein; Region: Rod-binding; cl01626 1322246002451 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 1322246002452 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 1322246002453 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK12696 1322246002454 Flagellar L-ring protein; Region: FlgH; pfam02107 1322246002455 SAF-like; Region: SAF_2; pfam13144 1322246002456 flagella basal body P-ring formation protein FlgA; Region: flgA_cterm; TIGR03170 1322246002457 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 1322246002458 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1322246002459 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1322246002460 flagellar hook-basal body protein; Region: FlgEFG_subfam; TIGR03506 1322246002461 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1322246002462 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 1322246002463 ribosome maturation protein RimP; Reviewed; Region: PRK00092 1322246002464 hypothetical protein; Provisional; Region: PRK14641 1322246002465 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 1322246002466 putative oligomer interface [polypeptide binding]; other site 1322246002467 putative RNA binding site [nucleotide binding]; other site 1322246002468 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 1322246002469 NusA N-terminal domain; Region: NusA_N; pfam08529 1322246002470 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1322246002471 RNA binding site [nucleotide binding]; other site 1322246002472 homodimer interface [polypeptide binding]; other site 1322246002473 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1322246002474 G-X-X-G motif; other site 1322246002475 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1322246002476 G-X-X-G motif; other site 1322246002477 Protein of unknown function (DUF448); Region: DUF448; pfam04296 1322246002478 putative RNA binding cleft [nucleotide binding]; other site 1322246002479 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1322246002480 translation initiation factor IF-2; Region: IF-2; TIGR00487 1322246002481 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1322246002482 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1322246002483 G1 box; other site 1322246002484 putative GEF interaction site [polypeptide binding]; other site 1322246002485 GTP/Mg2+ binding site [chemical binding]; other site 1322246002486 Switch I region; other site 1322246002487 G2 box; other site 1322246002488 G3 box; other site 1322246002489 Switch II region; other site 1322246002490 G4 box; other site 1322246002491 G5 box; other site 1322246002492 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1322246002493 Translation-initiation factor 2; Region: IF-2; pfam11987 1322246002494 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1322246002495 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 1322246002496 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 1322246002497 DHH family; Region: DHH; pfam01368 1322246002498 DHHA1 domain; Region: DHHA1; pfam02272 1322246002499 tRNA pseudouridine(55) synthase; Region: TruB; TIGR00431 1322246002500 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1322246002501 RNA binding site [nucleotide binding]; other site 1322246002502 active site 1322246002503 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1322246002504 16S/18S rRNA binding site [nucleotide binding]; other site 1322246002505 S13e-L30e interaction site [polypeptide binding]; other site 1322246002506 25S rRNA binding site [nucleotide binding]; other site 1322246002507 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 1322246002508 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 1322246002509 RNase E interface [polypeptide binding]; other site 1322246002510 trimer interface [polypeptide binding]; other site 1322246002511 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 1322246002512 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 1322246002513 RNase E interface [polypeptide binding]; other site 1322246002514 trimer interface [polypeptide binding]; other site 1322246002515 active site 1322246002516 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 1322246002517 putative nucleic acid binding region [nucleotide binding]; other site 1322246002518 G-X-X-G motif; other site 1322246002519 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1322246002520 RNA binding site [nucleotide binding]; other site 1322246002521 domain interface; other site 1322246002522 Glutaredoxin; Region: Glutaredoxin; pfam00462 1322246002523 Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility; Region: MEMO_like; cd07361 1322246002524 putative ligand binding pocket/active site [active] 1322246002525 putative metal binding site [ion binding]; other site 1322246002526 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 1322246002527 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1322246002528 binding surface 1322246002529 TPR motif; other site 1322246002530 Tetratricopeptide repeat; Region: TPR_6; pfam13174 1322246002531 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 1322246002532 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1322246002533 Walker A motif; other site 1322246002534 ATP binding site [chemical binding]; other site 1322246002535 Walker B motif; other site 1322246002536 arginine finger; other site 1322246002537 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1322246002538 conserved hypothetical protein; Region: TIGR02285 1322246002539 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 1322246002540 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1322246002541 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgC; COG1558 1322246002542 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1322246002543 putative GTP cyclohydrolase; Provisional; Region: PRK13674 1322246002544 nickel responsive regulator; Provisional; Region: PRK04460 1322246002545 Uncharacterized protein family (UPF0156); Region: RHH_2; cl17383 1322246002546 NikR C terminal nickel binding domain; Region: NikR_C; pfam08753 1322246002547 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1322246002548 S-adenosylmethionine binding site [chemical binding]; other site 1322246002549 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1322246002550 lipoyl attachment site [posttranslational modification]; other site 1322246002551 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 1322246002552 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1322246002553 tetramer interface [polypeptide binding]; other site 1322246002554 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1322246002555 catalytic residue [active] 1322246002556 glycine dehydrogenase subunit 2; Validated; Region: PRK04366 1322246002557 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1322246002558 catalytic residue [active] 1322246002559 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 1322246002560 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1322246002561 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1322246002562 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1322246002563 Domain of unknown function (DUF386); Region: DUF386; cl01047 1322246002564 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 1322246002565 active site residue [active] 1322246002566 putative voltage-gated ClC-type chloride channel ClcB; Provisional; Region: PRK01862 1322246002567 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 1322246002568 Cl- selectivity filter; other site 1322246002569 Cl- binding residues [ion binding]; other site 1322246002570 pore gating glutamate residue; other site 1322246002571 dimer interface [polypeptide binding]; other site 1322246002572 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc2; cd04613 1322246002573 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 1322246002574 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 1322246002575 Tetramer interface [polypeptide binding]; other site 1322246002576 active site 1322246002577 FMN-binding site [chemical binding]; other site 1322246002578 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1322246002579 TrkA-N domain; Region: TrkA_N; pfam02254 1322246002580 TrkA-C domain; Region: TrkA_C; pfam02080 1322246002581 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 1322246002582 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 1322246002583 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 1322246002584 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1322246002585 ADP binding site [chemical binding]; other site 1322246002586 magnesium binding site [ion binding]; other site 1322246002587 putative shikimate binding site; other site 1322246002588 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 1322246002589 NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; Region: NuoN; COG1007 1322246002590 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1322246002591 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 1322246002592 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1322246002593 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12668 1322246002594 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1322246002595 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK08375 1322246002596 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1322246002597 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 1322246002598 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 1322246002599 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 1322246002600 NADH dehydrogenase subunit J; Provisional; Region: PRK06439 1322246002601 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 1322246002602 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 1322246002603 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 1322246002604 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 1322246002605 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 1322246002606 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; pfam00329 1322246002607 NADH dehydrogenase subunit B; Validated; Region: PRK06411 1322246002608 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 1322246002609 Response regulator receiver domain; Region: Response_reg; pfam00072 1322246002610 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1322246002611 active site 1322246002612 phosphorylation site [posttranslational modification] 1322246002613 intermolecular recognition site; other site 1322246002614 dimerization interface [polypeptide binding]; other site 1322246002615 PAS domain S-box; Region: sensory_box; TIGR00229 1322246002616 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1322246002617 putative active site [active] 1322246002618 heme pocket [chemical binding]; other site 1322246002619 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1322246002620 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1322246002621 metal binding site [ion binding]; metal-binding site 1322246002622 active site 1322246002623 I-site; other site 1322246002624 2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; pfam04029 1322246002625 Phosphosulfolactate phosphohydrolase and related enzymes [Coenzyme metabolism / General function prediction only]; Region: COG2045 1322246002626 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1322246002627 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 1322246002628 NAD binding site [chemical binding]; other site 1322246002629 putative substrate binding site 2 [chemical binding]; other site 1322246002630 putative substrate binding site 1 [chemical binding]; other site 1322246002631 active site 1322246002632 Transposase domain (DUF772); Region: DUF772; pfam05598 1322246002633 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1322246002634 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1322246002635 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1322246002636 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1322246002637 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 1322246002638 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 1322246002639 active site 1322246002640 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1322246002641 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1322246002642 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1322246002643 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 1322246002644 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1322246002645 Ligand binding site; other site 1322246002646 Putative Catalytic site; other site 1322246002647 DXD motif; other site 1322246002648 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 1322246002649 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1322246002650 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1322246002651 putative active site [active] 1322246002652 heme pocket [chemical binding]; other site 1322246002653 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1322246002654 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1322246002655 putative active site [active] 1322246002656 heme pocket [chemical binding]; other site 1322246002657 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1322246002658 dimer interface [polypeptide binding]; other site 1322246002659 phosphorylation site [posttranslational modification] 1322246002660 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1322246002661 ATP binding site [chemical binding]; other site 1322246002662 Mg2+ binding site [ion binding]; other site 1322246002663 G-X-G motif; other site 1322246002664 Response regulator receiver domain; Region: Response_reg; pfam00072 1322246002665 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1322246002666 active site 1322246002667 phosphorylation site [posttranslational modification] 1322246002668 intermolecular recognition site; other site 1322246002669 dimerization interface [polypeptide binding]; other site 1322246002670 thiamine biosynthesis protein ThiC; Provisional; Region: PRK13352 1322246002671 thiamine biosynthesis protein ThiC; Region: thiC; TIGR00190 1322246002672 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1322246002673 thiamine phosphate binding site [chemical binding]; other site 1322246002674 active site 1322246002675 pyrophosphate binding site [ion binding]; other site 1322246002676 thiamine biosynthesis protein ThiF; Provisional; Region: PRK08644 1322246002677 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196 1322246002678 ATP binding site [chemical binding]; other site 1322246002679 substrate interface [chemical binding]; other site 1322246002680 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240 1322246002681 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1322246002682 FeS/SAM binding site; other site 1322246002683 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 1322246002684 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 1322246002685 ThiS interaction site; other site 1322246002686 putative active site [active] 1322246002687 tetramer interface [polypeptide binding]; other site 1322246002688 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 1322246002689 thiS-thiF/thiG interaction site; other site 1322246002690 Bacterial SH3 domain; Region: SH3_3; pfam08239 1322246002691 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 1322246002692 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 1322246002693 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1322246002694 ATP binding site [chemical binding]; other site 1322246002695 putative Mg++ binding site [ion binding]; other site 1322246002696 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1322246002697 nucleotide binding region [chemical binding]; other site 1322246002698 ATP-binding site [chemical binding]; other site 1322246002699 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1322246002700 active site 1322246002701 tetramer interface; other site 1322246002702 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14314 1322246002703 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1322246002704 active site 1322246002705 substrate binding site [chemical binding]; other site 1322246002706 metal binding site [ion binding]; metal-binding site 1322246002707 YbbR-like protein; Region: YbbR; pfam07949 1322246002708 YbbR-like protein; Region: YbbR; pfam07949 1322246002709 Uncharacterized conserved protein [Function unknown]; Region: COG1624 1322246002710 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 1322246002711 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1322246002712 dihydropteroate synthase; Region: DHPS; TIGR01496 1322246002713 substrate binding pocket [chemical binding]; other site 1322246002714 dimer interface [polypeptide binding]; other site 1322246002715 inhibitor binding site; inhibition site 1322246002716 FtsH Extracellular; Region: FtsH_ext; pfam06480 1322246002717 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 1322246002718 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1322246002719 Walker A motif; other site 1322246002720 ATP binding site [chemical binding]; other site 1322246002721 Walker B motif; other site 1322246002722 arginine finger; other site 1322246002723 Peptidase family M41; Region: Peptidase_M41; pfam01434 1322246002724 argininosuccinate lyase; Provisional; Region: PRK00855 1322246002725 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1322246002726 active sites [active] 1322246002727 tetramer interface [polypeptide binding]; other site 1322246002728 argininosuccinate synthase; Provisional; Region: PRK13820 1322246002729 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 1322246002730 ANP binding site [chemical binding]; other site 1322246002731 Substrate Binding Site II [chemical binding]; other site 1322246002732 Substrate Binding Site I [chemical binding]; other site 1322246002733 ornithine carbamoyltransferase; Provisional; Region: PRK00779 1322246002734 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1322246002735 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1322246002736 Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130 1322246002737 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1322246002738 PhoH-like protein; Region: PhoH; pfam02562 1322246002739 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1322246002740 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1322246002741 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1322246002742 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1322246002743 Walker A/P-loop; other site 1322246002744 ATP binding site [chemical binding]; other site 1322246002745 Q-loop/lid; other site 1322246002746 ABC transporter signature motif; other site 1322246002747 Walker B; other site 1322246002748 D-loop; other site 1322246002749 H-loop/switch region; other site 1322246002750 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 1322246002751 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1322246002752 Predicted permeases [General function prediction only]; Region: COG0701 1322246002753 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1322246002754 dimerization interface [polypeptide binding]; other site 1322246002755 putative DNA binding site [nucleotide binding]; other site 1322246002756 putative Zn2+ binding site [ion binding]; other site 1322246002757 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 1322246002758 dimer interface [polypeptide binding]; other site 1322246002759 catalytic triad [active] 1322246002760 peroxidatic and resolving cysteines [active] 1322246002761 glutamate dehydrogenase 2; Provisional; Region: PTZ00324 1322246002762 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1322246002763 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 1322246002764 NAD(P) binding pocket [chemical binding]; other site 1322246002765 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 1322246002766 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 1322246002767 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1322246002768 active site 1322246002769 phosphorylation site [posttranslational modification] 1322246002770 intermolecular recognition site; other site 1322246002771 dimerization interface [polypeptide binding]; other site 1322246002772 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1322246002773 putative binding surface; other site 1322246002774 active site 1322246002775 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; pfam01977 1322246002776 Hemerythrin; Region: Hemerythrin; cd12107 1322246002777 Fe binding site [ion binding]; other site 1322246002778 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 1322246002779 Flavoprotein; Region: Flavoprotein; pfam02441 1322246002780 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1322246002781 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1322246002782 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1322246002783 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1322246002784 GIY-YIG motif/motif A; other site 1322246002785 active site 1322246002786 catalytic site [active] 1322246002787 putative DNA binding site [nucleotide binding]; other site 1322246002788 metal binding site [ion binding]; metal-binding site 1322246002789 UvrB/uvrC motif; Region: UVR; pfam02151 1322246002790 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1322246002791 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 1322246002792 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 1322246002793 histidinol dehydrogenase; Region: hisD; TIGR00069 1322246002794 NAD binding site [chemical binding]; other site 1322246002795 dimerization interface [polypeptide binding]; other site 1322246002796 product binding site; other site 1322246002797 substrate binding site [chemical binding]; other site 1322246002798 zinc binding site [ion binding]; other site 1322246002799 catalytic residues [active] 1322246002800 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 1322246002801 ATP binding site [chemical binding]; other site 1322246002802 active site 1322246002803 substrate binding site [chemical binding]; other site 1322246002804 Ribosomal protein S6; Region: Ribosomal_S6; pfam01250 1322246002805 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 1322246002806 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1322246002807 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1322246002808 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1322246002809 replicative DNA helicase; Region: DnaB; TIGR00665 1322246002810 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1322246002811 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1322246002812 Walker A motif; other site 1322246002813 ATP binding site [chemical binding]; other site 1322246002814 Walker B motif; other site 1322246002815 DNA binding loops [nucleotide binding] 1322246002816 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 1322246002817 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1322246002818 acyl-activating enzyme (AAE) consensus motif; other site 1322246002819 AMP binding site [chemical binding]; other site 1322246002820 active site 1322246002821 CoA binding site [chemical binding]; other site 1322246002822 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1322246002823 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1322246002824 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1322246002825 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1322246002826 dimerization interface [polypeptide binding]; other site 1322246002827 hypothetical protein; Provisional; Region: PRK10279 1322246002828 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 1322246002829 active site 1322246002830 nucleophile elbow; other site 1322246002831 threonine synthase; Validated; Region: PRK08197 1322246002832 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 1322246002833 homodimer interface [polypeptide binding]; other site 1322246002834 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1322246002835 catalytic residue [active] 1322246002836 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 1322246002837 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 1322246002838 RNA binding surface [nucleotide binding]; other site 1322246002839 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1322246002840 S-adenosylmethionine binding site [chemical binding]; other site 1322246002841 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1322246002842 active site residue [active] 1322246002843 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045 1322246002844 diiron binding motif [ion binding]; other site 1322246002845 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1322246002846 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1322246002847 Walker A/P-loop; other site 1322246002848 ATP binding site [chemical binding]; other site 1322246002849 Q-loop/lid; other site 1322246002850 ABC transporter signature motif; other site 1322246002851 Walker B; other site 1322246002852 D-loop; other site 1322246002853 H-loop/switch region; other site 1322246002854 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 1322246002855 Domain of unknown function (DUF4198); Region: DUF4198; pfam10670 1322246002856 bile acid transporter; Region: bass; TIGR00841 1322246002857 Sodium Bile acid symporter family; Region: SBF; cl17470 1322246002858 radical SAM/Cys-rich domain protein; Region: rSAM_SeCys; TIGR04167 1322246002859 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1322246002860 FeS/SAM binding site; other site 1322246002861 Protein of unknown function (DUF3641); Region: DUF3641; pfam12345 1322246002862 Sodium:sulfate symporter transmembrane region; Region: Na_sulph_symp; pfam00939 1322246002863 transmembrane helices; other site 1322246002864 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1322246002865 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1322246002866 DNA binding site [nucleotide binding] 1322246002867 active site 1322246002868 Int/Topo IB signature motif; other site 1322246002869 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 1322246002870 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 1322246002871 heterodimer interface [polypeptide binding]; other site 1322246002872 active site 1322246002873 FMN binding site [chemical binding]; other site 1322246002874 homodimer interface [polypeptide binding]; other site 1322246002875 substrate binding site [chemical binding]; other site 1322246002876 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 1322246002877 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 1322246002878 FAD binding pocket [chemical binding]; other site 1322246002879 FAD binding motif [chemical binding]; other site 1322246002880 phosphate binding motif [ion binding]; other site 1322246002881 beta-alpha-beta structure motif; other site 1322246002882 NAD binding pocket [chemical binding]; other site 1322246002883 Iron coordination center [ion binding]; other site 1322246002884 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1322246002885 Peptidase family U32; Region: Peptidase_U32; pfam01136 1322246002886 Peptidase family U32; Region: Peptidase_U32; cl03113 1322246002887 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 1322246002888 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 1322246002889 Transglycosylase; Region: Transgly; pfam00912 1322246002890 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1322246002891 Flagellin N-methylase; Region: FliB; cl00497 1322246002892 KpsF/GutQ family protein; Region: kpsF; TIGR00393 1322246002893 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 1322246002894 putative active site [active] 1322246002895 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 1322246002896 Glutamine phosphoribosylpyrophosphate amidotransferase [Nucleotide transport and metabolism]; Region: PurF; COG0034 1322246002897 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1322246002898 active site 1322246002899 tetramer interface [polypeptide binding]; other site 1322246002900 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1322246002901 active site 1322246002902 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1322246002903 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1322246002904 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1322246002905 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1322246002906 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1322246002907 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1322246002908 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 1322246002909 IMP binding site; other site 1322246002910 dimer interface [polypeptide binding]; other site 1322246002911 interdomain contacts; other site 1322246002912 partial ornithine binding site; other site 1322246002913 Protein of unknown function (DUF523); Region: DUF523; pfam04463 1322246002914 Uncharacterized conserved protein [Function unknown]; Region: COG3272 1322246002915 Protein of unknown function (DUF1722); Region: DUF1722; pfam08349 1322246002916 Protein of unknown function (DUF523); Region: DUF523; pfam04463 1322246002917 Uncharacterized conserved protein [Function unknown]; Region: COG3272 1322246002918 Protein of unknown function (DUF1722); Region: DUF1722; pfam08349 1322246002919 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1322246002920 TPR motif; other site 1322246002921 binding surface 1322246002922 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 1322246002923 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1322246002924 active site 1322246002925 HIGH motif; other site 1322246002926 KMSKS motif; other site 1322246002927 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1322246002928 tRNA binding surface [nucleotide binding]; other site 1322246002929 anticodon binding site; other site 1322246002930 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 1322246002931 dimer interface [polypeptide binding]; other site 1322246002932 putative tRNA-binding site [nucleotide binding]; other site 1322246002933 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 1322246002934 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1322246002935 Response regulator receiver domain; Region: Response_reg; pfam00072 1322246002936 active site 1322246002937 phosphorylation site [posttranslational modification] 1322246002938 intermolecular recognition site; other site 1322246002939 dimerization interface [polypeptide binding]; other site 1322246002940 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 1322246002941 HDOD domain; Region: HDOD; pfam08668 1322246002942 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1322246002943 Zn2+ binding site [ion binding]; other site 1322246002944 Mg2+ binding site [ion binding]; other site 1322246002945 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 1322246002946 DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361 1322246002947 Competence protein; Region: Competence; pfam03772 1322246002948 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1322246002949 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1322246002950 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1322246002951 Walker A motif; other site 1322246002952 ATP binding site [chemical binding]; other site 1322246002953 Walker B motif; other site 1322246002954 arginine finger; other site 1322246002955 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1322246002956 Holliday junction DNA helicase RuvA; Provisional; Region: ruvA; PRK14602 1322246002957 RuvA N terminal domain; Region: RuvA_N; pfam01330 1322246002958 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 1322246002959 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 1322246002960 active site 1322246002961 putative DNA-binding cleft [nucleotide binding]; other site 1322246002962 dimer interface [polypeptide binding]; other site 1322246002963 hypothetical protein; Validated; Region: PRK00110 1322246002964 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 1322246002965 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1322246002966 S-adenosylmethionine binding site [chemical binding]; other site 1322246002967 DUF based on E. rectale Gene description (DUF3880); Region: DUF3880; pfam12996 1322246002968 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 1322246002969 RT_like: Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons; Region: RT_like; cl02808 1322246002970 RT_like: Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons; Region: RT_like; cl02808 1322246002971 Integrase core domain; Region: rve; pfam00665 1322246002972 Integrase core domain; Region: rve_3; pfam13683 1322246002973 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1322246002974 Transposase; Region: HTH_Tnp_1; pfam01527 1322246002975 Transposase domain (DUF772); Region: DUF772; pfam05598 1322246002976 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1322246002977 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1322246002978 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 1322246002979 glyoxylate reductase; Reviewed; Region: PRK13243 1322246002980 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 1322246002981 dimerization interface [polypeptide binding]; other site 1322246002982 ligand binding site [chemical binding]; other site 1322246002983 NADP binding site [chemical binding]; other site 1322246002984 catalytic site [active] 1322246002985 Domain of unknown function (DUF4147); Region: DUF4147; pfam13660 1322246002986 Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379 1322246002987 MOFRL family; Region: MOFRL; pfam05161 1322246002988 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1322246002989 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1322246002990 dimerization interface [polypeptide binding]; other site 1322246002991 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1322246002992 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1322246002993 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1322246002994 putative active site [active] 1322246002995 heme pocket [chemical binding]; other site 1322246002996 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1322246002997 dimer interface [polypeptide binding]; other site 1322246002998 phosphorylation site [posttranslational modification] 1322246002999 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1322246003000 ATP binding site [chemical binding]; other site 1322246003001 Mg2+ binding site [ion binding]; other site 1322246003002 G-X-G motif; other site 1322246003003 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1322246003004 active site 1322246003005 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1322246003006 phosphorylation site [posttranslational modification] 1322246003007 intermolecular recognition site; other site 1322246003008 dimerization interface [polypeptide binding]; other site 1322246003009 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 1322246003010 dimer interface [polypeptide binding]; other site 1322246003011 phosphorylation site [posttranslational modification] 1322246003012 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1322246003013 ATP binding site [chemical binding]; other site 1322246003014 Mg2+ binding site [ion binding]; other site 1322246003015 G-X-G motif; other site 1322246003016 Response regulator receiver domain; Region: Response_reg; pfam00072 1322246003017 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1322246003018 active site 1322246003019 phosphorylation site [posttranslational modification] 1322246003020 intermolecular recognition site; other site 1322246003021 dimerization interface [polypeptide binding]; other site 1322246003022 PAS domain; Region: PAS_9; pfam13426 1322246003023 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1322246003024 PAS domain; Region: PAS_9; pfam13426 1322246003025 putative active site [active] 1322246003026 heme pocket [chemical binding]; other site 1322246003027 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1322246003028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1322246003029 ATP binding site [chemical binding]; other site 1322246003030 Mg2+ binding site [ion binding]; other site 1322246003031 G-X-G motif; other site 1322246003032 HAMP domain; Region: HAMP; pfam00672 1322246003033 PAS domain; Region: PAS_9; pfam13426 1322246003034 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1322246003035 putative active site [active] 1322246003036 heme pocket [chemical binding]; other site 1322246003037 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1322246003038 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1322246003039 dimer interface [polypeptide binding]; other site 1322246003040 putative CheW interface [polypeptide binding]; other site 1322246003041 PBP superfamily domain; Region: PBP_like_2; cl17296 1322246003042 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1322246003043 uncharacterized radical SAM protein YgiQ; Region: SAM_YgiQ; TIGR03904 1322246003044 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 1322246003045 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 1322246003046 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1322246003047 ATP binding site [chemical binding]; other site 1322246003048 Mg++ binding site [ion binding]; other site 1322246003049 motif III; other site 1322246003050 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1322246003051 nucleotide binding region [chemical binding]; other site 1322246003052 ATP-binding site [chemical binding]; other site 1322246003053 Response regulator receiver domain; Region: Response_reg; pfam00072 1322246003054 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1322246003055 active site 1322246003056 phosphorylation site [posttranslational modification] 1322246003057 intermolecular recognition site; other site 1322246003058 dimerization interface [polypeptide binding]; other site 1322246003059 Response regulator receiver domain; Region: Response_reg; pfam00072 1322246003060 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1322246003061 active site 1322246003062 phosphorylation site [posttranslational modification] 1322246003063 intermolecular recognition site; other site 1322246003064 dimerization interface [polypeptide binding]; other site 1322246003065 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1322246003066 Ligand Binding Site [chemical binding]; other site 1322246003067 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1322246003068 Ligand Binding Site [chemical binding]; other site 1322246003069 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 1322246003070 heme-binding residues [chemical binding]; other site 1322246003071 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1322246003072 Cysteine-rich domain; Region: CCG; pfam02754 1322246003073 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959 1322246003074 Dinitrogenase iron-molybdenum cofactor; Region: Nitro_FeMo-Co; pfam02579 1322246003075 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1322246003076 PAS domain; Region: PAS_9; pfam13426 1322246003077 putative active site [active] 1322246003078 heme pocket [chemical binding]; other site 1322246003079 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1322246003080 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 1322246003081 Walker A motif; other site 1322246003082 ATP binding site [chemical binding]; other site 1322246003083 Walker B motif; other site 1322246003084 arginine finger; other site 1322246003085 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1322246003086 Family description; Region: DsbD_2; pfam13386 1322246003087 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1322246003088 MarR family; Region: MarR; pfam01047 1322246003089 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1322246003090 active site residue [active] 1322246003091 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1322246003092 Response regulator receiver domain; Region: Response_reg; pfam00072 1322246003093 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1322246003094 active site 1322246003095 phosphorylation site [posttranslational modification] 1322246003096 intermolecular recognition site; other site 1322246003097 dimerization interface [polypeptide binding]; other site 1322246003098 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1322246003099 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1322246003100 putative active site [active] 1322246003101 heme pocket [chemical binding]; other site 1322246003102 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1322246003103 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1322246003104 putative active site [active] 1322246003105 heme pocket [chemical binding]; other site 1322246003106 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1322246003107 putative active site [active] 1322246003108 heme pocket [chemical binding]; other site 1322246003109 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 1322246003110 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1322246003111 Walker A motif; other site 1322246003112 ATP binding site [chemical binding]; other site 1322246003113 Walker B motif; other site 1322246003114 arginine finger; other site 1322246003115 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1322246003116 Response regulator receiver domain; Region: Response_reg; pfam00072 1322246003117 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1322246003118 active site 1322246003119 phosphorylation site [posttranslational modification] 1322246003120 intermolecular recognition site; other site 1322246003121 dimerization interface [polypeptide binding]; other site 1322246003122 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1322246003123 This family is most closely related to the GT1 family of glycosyltransferases. ExpC in Rhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucan (exopolysaccharide II); Region: GT1_ExpC_like; cd03818 1322246003124 putative ADP-binding pocket [chemical binding]; other site 1322246003125 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1322246003126 active site 1322246003127 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1322246003128 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1322246003129 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 1322246003130 acyl-activating enzyme (AAE) consensus motif; other site 1322246003131 acyl-activating enzyme (AAE) consensus motif; other site 1322246003132 putative AMP binding site [chemical binding]; other site 1322246003133 putative active site [active] 1322246003134 putative CoA binding site [chemical binding]; other site 1322246003135 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 1322246003136 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1322246003137 substrate binding pocket [chemical binding]; other site 1322246003138 membrane-bound complex binding site; other site 1322246003139 hinge residues; other site 1322246003140 PAS domain; Region: PAS_9; pfam13426 1322246003141 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1322246003142 PAS fold; Region: PAS_3; pfam08447 1322246003143 putative active site [active] 1322246003144 heme pocket [chemical binding]; other site 1322246003145 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1322246003146 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1322246003147 dimer interface [polypeptide binding]; other site 1322246003148 phosphorylation site [posttranslational modification] 1322246003149 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1322246003150 ATP binding site [chemical binding]; other site 1322246003151 Mg2+ binding site [ion binding]; other site 1322246003152 G-X-G motif; other site 1322246003153 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1322246003154 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1322246003155 active site 1322246003156 phosphorylation site [posttranslational modification] 1322246003157 intermolecular recognition site; other site 1322246003158 dimerization interface [polypeptide binding]; other site 1322246003159 Predicted membrane protein [Function unknown]; Region: COG4392 1322246003160 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 1322246003161 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1322246003162 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1322246003163 DNA-binding site [nucleotide binding]; DNA binding site 1322246003164 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1322246003165 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1322246003166 homodimer interface [polypeptide binding]; other site 1322246003167 catalytic residue [active] 1322246003168 Predicted permeases [General function prediction only]; Region: RarD; COG2962 1322246003169 EamA-like transporter family; Region: EamA; cl17759 1322246003170 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1322246003171 Protein of unknown function (DUF401); Region: DUF401; cl00830 1322246003172 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 1322246003173 Catalytic site; other site 1322246003174 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 1322246003175 PhnA protein; Region: PhnA; pfam03831 1322246003176 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 1322246003177 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 1322246003178 putative catalytic cysteine [active] 1322246003179 poly-beta-1,6 N-acetyl-D-glucosamine export porin PgaA; Region: PGA_TPR_OMP; TIGR03939 1322246003180 indolepyruvate ferredoxin oxidoreductase, alpha subunit; Region: IOR_alpha; TIGR03336 1322246003181 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 1322246003182 dimer interface [polypeptide binding]; other site 1322246003183 PYR/PP interface [polypeptide binding]; other site 1322246003184 TPP binding site [chemical binding]; other site 1322246003185 substrate binding site [chemical binding]; other site 1322246003186 Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008 1322246003187 TPP-binding site; other site 1322246003188 indolepyruvate oxidoreductase subunit beta; Reviewed; Region: PRK06853 1322246003189 Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains [Transcription / Signal transduction mechanisms]; Region: FhlA; COG3604 1322246003190 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1322246003191 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1322246003192 Walker A motif; other site 1322246003193 ATP binding site [chemical binding]; other site 1322246003194 Walker B motif; other site 1322246003195 arginine finger; other site 1322246003196 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 1322246003197 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1322246003198 active site 1322246003199 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1322246003200 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1322246003201 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1322246003202 active site 1322246003203 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1322246003204 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 1322246003205 active site 1322246003206 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1322246003207 DNA-binding site [nucleotide binding]; DNA binding site 1322246003208 RNA-binding motif; other site 1322246003209 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 1322246003210 putative molybdenum transport ATP-binding protein ModF; Provisional; Region: PRK10938 1322246003211 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1322246003212 Walker A/P-loop; other site 1322246003213 ATP binding site [chemical binding]; other site 1322246003214 Q-loop/lid; other site 1322246003215 ABC transporter signature motif; other site 1322246003216 Walker B; other site 1322246003217 D-loop; other site 1322246003218 H-loop/switch region; other site 1322246003219 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1322246003220 Walker A/P-loop; other site 1322246003221 ATP binding site [chemical binding]; other site 1322246003222 Q-loop/lid; other site 1322246003223 ABC transporter signature motif; other site 1322246003224 Walker B; other site 1322246003225 D-loop; other site 1322246003226 H-loop/switch region; other site 1322246003227 Uncharacterized conserved protein [Function unknown]; Region: COG2006 1322246003228 Domain of unknown function (DUF362); Region: DUF362; pfam04015 1322246003229 Acylphosphatase; Region: Acylphosphatase; pfam00708 1322246003230 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 1322246003231 HypF finger; Region: zf-HYPF; pfam07503 1322246003232 HypF finger; Region: zf-HYPF; pfam07503 1322246003233 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 1322246003234 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 1322246003235 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 1322246003236 Proteolipid membrane potential modulator; Region: Pmp3; pfam01679 1322246003237 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1322246003238 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1322246003239 dimer interface [polypeptide binding]; other site 1322246003240 putative CheW interface [polypeptide binding]; other site 1322246003241 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 1322246003242 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 1322246003243 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1322246003244 catalytic residue [active] 1322246003245 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1322246003246 FAD binding domain; Region: FAD_binding_4; pfam01565 1322246003247 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 1322246003248 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1322246003249 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1322246003250 Cysteine-rich domain; Region: CCG; pfam02754 1322246003251 Cysteine-rich domain; Region: CCG; pfam02754 1322246003252 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 1322246003253 YceG-like family; Region: YceG; pfam02618 1322246003254 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 1322246003255 dimerization interface [polypeptide binding]; other site 1322246003256 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 1322246003257 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 1322246003258 homodimer interface [polypeptide binding]; other site 1322246003259 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1322246003260 catalytic residue [active] 1322246003261 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1322246003262 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1322246003263 active site 1322246003264 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 1322246003265 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 1322246003266 Ligand Binding Site [chemical binding]; other site 1322246003267 TIGR00269 family protein; Region: TIGR00269 1322246003268 Ubiquitin-like proteins; Region: UBQ; cl00155 1322246003269 charged pocket; other site 1322246003270 hydrophobic patch; other site 1322246003271 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1322246003272 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1322246003273 active site 1322246003274 phosphorylation site [posttranslational modification] 1322246003275 intermolecular recognition site; other site 1322246003276 dimerization interface [polypeptide binding]; other site 1322246003277 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1322246003278 Zn2+ binding site [ion binding]; other site 1322246003279 Mg2+ binding site [ion binding]; other site 1322246003280 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 1322246003281 Peptidase family M50; Region: Peptidase_M50; pfam02163 1322246003282 active site 1322246003283 putative substrate binding region [chemical binding]; other site 1322246003284 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1322246003285 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1322246003286 active site 1322246003287 HIGH motif; other site 1322246003288 dimer interface [polypeptide binding]; other site 1322246003289 KMSKS motif; other site 1322246003290 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 1322246003291 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1322246003292 aspartate aminotransferase; Provisional; Region: PRK05764 1322246003293 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1322246003294 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1322246003295 homodimer interface [polypeptide binding]; other site 1322246003296 catalytic residue [active] 1322246003297 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1322246003298 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1322246003299 dimer interface [polypeptide binding]; other site 1322246003300 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1322246003301 catalytic residue [active] 1322246003302 cysteinyl-tRNA synthetase; Region: cysS; TIGR00435 1322246003303 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1322246003304 Protein of unknown function DUF115; Region: MAF_flag10; pfam01973 1322246003305 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1322246003306 MarR family; Region: MarR_2; cl17246 1322246003307 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1322246003308 putative substrate translocation pore; other site 1322246003309 phosphoglucomutase; Validated; Region: PRK07564 1322246003310 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 1322246003311 active site 1322246003312 substrate binding site [chemical binding]; other site 1322246003313 metal binding site [ion binding]; metal-binding site 1322246003314 Cache domain; Region: Cache_1; pfam02743 1322246003315 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1322246003316 dimerization interface [polypeptide binding]; other site 1322246003317 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1322246003318 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1322246003319 dimer interface [polypeptide binding]; other site 1322246003320 putative CheW interface [polypeptide binding]; other site 1322246003321 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1322246003322 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1322246003323 ligand binding site [chemical binding]; other site 1322246003324 Peptidase family M48; Region: Peptidase_M48; pfam01435 1322246003325 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1322246003326 TPR motif; other site 1322246003327 binding surface 1322246003328 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1322246003329 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 1322246003330 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1322246003331 dimerization interface [polypeptide binding]; other site 1322246003332 substrate binding pocket [chemical binding]; other site 1322246003333 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 1322246003334 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1322246003335 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1322246003336 dimerization interface [polypeptide binding]; other site 1322246003337 substrate binding pocket [chemical binding]; other site 1322246003338 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1322246003339 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1322246003340 ring oligomerisation interface [polypeptide binding]; other site 1322246003341 ATP/Mg binding site [chemical binding]; other site 1322246003342 stacking interactions; other site 1322246003343 hinge regions; other site 1322246003344 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1322246003345 oligomerisation interface [polypeptide binding]; other site 1322246003346 mobile loop; other site 1322246003347 roof hairpin; other site 1322246003348 Hemerythrin; Region: Hemerythrin; cd12107 1322246003349 Fe binding site [ion binding]; other site 1322246003350 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ACT14924; Region: LPLAT_ACT14924-like; cd07986 1322246003351 putative acyl-acceptor binding pocket; other site 1322246003352 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444 1322246003353 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1322246003354 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1322246003355 dimerization interface [polypeptide binding]; other site 1322246003356 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1322246003357 dimer interface [polypeptide binding]; other site 1322246003358 putative CheW interface [polypeptide binding]; other site 1322246003359 Possible lysine decarboxylase; Region: Lysine_decarbox; pfam03641 1322246003360 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 1322246003361 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 1322246003362 tetramer interface [polypeptide binding]; other site 1322246003363 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1322246003364 catalytic residue [active] 1322246003365 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1322246003366 active site 1322246003367 catalytic triad [active] 1322246003368 oxyanion hole [active] 1322246003369 GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Region: GT_2_like_a; cd02522 1322246003370 transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283 1322246003371 Probable Catalytic site; other site 1322246003372 transferase 1, rSAM/selenodomain-associated; Region: glyco_like_cofC; TIGR04282 1322246003373 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 1322246003374 pentamer interface [polypeptide binding]; other site 1322246003375 dodecaamer interface [polypeptide binding]; other site 1322246003376 Fip1 motif; Region: Fip1; cl02162 1322246003377 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1322246003378 active site 1322246003379 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 1322246003380 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 1322246003381 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 1322246003382 BON domain; Region: BON; pfam04972 1322246003383 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1322246003384 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1322246003385 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1322246003386 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 1322246003387 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 1322246003388 methionine sulfoxide reductase A; Provisional; Region: PRK14054 1322246003389 methionine sulfoxide reductase B; Provisional; Region: PRK00222 1322246003390 SelR domain; Region: SelR; pfam01641 1322246003391 Late competence development protein ComFB; Region: ComFB; pfam10719 1322246003392 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1322246003393 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1322246003394 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1322246003395 HlyD family secretion protein; Region: HlyD_3; pfam13437 1322246003396 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1322246003397 MarR family; Region: MarR_2; pfam12802 1322246003398 PHP family phosphoesterase with a Zn ribbon [General function prediction only]; Region: COG1379 1322246003399 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1322246003400 Part of AAA domain; Region: AAA_19; pfam13245 1322246003401 Family description; Region: UvrD_C_2; pfam13538 1322246003402 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 1322246003403 homotrimer interface [polypeptide binding]; other site 1322246003404 Walker A motif; other site 1322246003405 GTP binding site [chemical binding]; other site 1322246003406 Walker B motif; other site 1322246003407 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 1322246003408 DHH family; Region: DHH; pfam01368 1322246003409 DNA polymerase I; Provisional; Region: PRK05755 1322246003410 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1322246003411 active site 1322246003412 metal binding site 1 [ion binding]; metal-binding site 1322246003413 putative 5' ssDNA interaction site; other site 1322246003414 metal binding site 3; metal-binding site 1322246003415 metal binding site 2 [ion binding]; metal-binding site 1322246003416 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1322246003417 putative DNA binding site [nucleotide binding]; other site 1322246003418 putative metal binding site [ion binding]; other site 1322246003419 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 1322246003420 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1322246003421 active site 1322246003422 DNA binding site [nucleotide binding] 1322246003423 catalytic site [active] 1322246003424 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 1322246003425 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 1322246003426 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 1322246003427 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 1322246003428 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 1322246003429 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 1322246003430 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 1322246003431 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1322246003432 acyl-activating enzyme (AAE) consensus motif; other site 1322246003433 AMP binding site [chemical binding]; other site 1322246003434 active site 1322246003435 CoA binding site [chemical binding]; other site 1322246003436 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698 1322246003437 Asp-box motif; other site 1322246003438 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1322246003439 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1322246003440 binding surface 1322246003441 TPR motif; other site 1322246003442 TPR repeat; Region: TPR_11; pfam13414 1322246003443 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 1322246003444 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1322246003445 rRNA binding site [nucleotide binding]; other site 1322246003446 predicted 30S ribosome binding site; other site 1322246003447 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 1322246003448 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1322246003449 ATP binding site [chemical binding]; other site 1322246003450 Mg++ binding site [ion binding]; other site 1322246003451 motif III; other site 1322246003452 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1322246003453 nucleotide binding region [chemical binding]; other site 1322246003454 ATP-binding site [chemical binding]; other site 1322246003455 RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252 1322246003456 RNA binding site [nucleotide binding]; other site 1322246003457 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1322246003458 active site residue [active] 1322246003459 YceI-like domain; Region: YceI; pfam04264 1322246003460 Protein of unknown function (DUF3088); Region: DUF3088; pfam11287 1322246003461 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 1322246003462 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1322246003463 dimerization interface [polypeptide binding]; other site 1322246003464 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1322246003465 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1322246003466 dimer interface [polypeptide binding]; other site 1322246003467 putative CheW interface [polypeptide binding]; other site 1322246003468 Hemerythrin; Region: Hemerythrin; cd12107 1322246003469 Fe binding site [ion binding]; other site 1322246003470 PAS domain S-box; Region: sensory_box; TIGR00229 1322246003471 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1322246003472 putative active site [active] 1322246003473 heme pocket [chemical binding]; other site 1322246003474 PAS domain S-box; Region: sensory_box; TIGR00229 1322246003475 PAS domain S-box; Region: sensory_box; TIGR00229 1322246003476 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1322246003477 putative active site [active] 1322246003478 heme pocket [chemical binding]; other site 1322246003479 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1322246003480 PAS fold; Region: PAS_3; pfam08447 1322246003481 putative active site [active] 1322246003482 heme pocket [chemical binding]; other site 1322246003483 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1322246003484 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1322246003485 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1322246003486 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1322246003487 dimer interface [polypeptide binding]; other site 1322246003488 phosphorylation site [posttranslational modification] 1322246003489 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1322246003490 ATP binding site [chemical binding]; other site 1322246003491 Mg2+ binding site [ion binding]; other site 1322246003492 G-X-G motif; other site 1322246003493 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1322246003494 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1322246003495 dimer interface [polypeptide binding]; other site 1322246003496 phosphorylation site [posttranslational modification] 1322246003497 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1322246003498 ATP binding site [chemical binding]; other site 1322246003499 Mg2+ binding site [ion binding]; other site 1322246003500 G-X-G motif; other site 1322246003501 Response regulator receiver domain; Region: Response_reg; pfam00072 1322246003502 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1322246003503 active site 1322246003504 phosphorylation site [posttranslational modification] 1322246003505 intermolecular recognition site; other site 1322246003506 dimerization interface [polypeptide binding]; other site 1322246003507 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 1322246003508 PAS fold; Region: PAS_4; pfam08448 1322246003509 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1322246003510 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1322246003511 dimer interface [polypeptide binding]; other site 1322246003512 putative CheW interface [polypeptide binding]; other site 1322246003513 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 1322246003514 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1322246003515 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1322246003516 protein binding site [polypeptide binding]; other site 1322246003517 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1322246003518 protein binding site [polypeptide binding]; other site 1322246003519 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14615 1322246003520 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 1322246003521 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1322246003522 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1322246003523 active site 1322246003524 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 1322246003525 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 1322246003526 5S rRNA interface [nucleotide binding]; other site 1322246003527 CTC domain interface [polypeptide binding]; other site 1322246003528 L16 interface [polypeptide binding]; other site 1322246003529 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1322246003530 putative active site [active] 1322246003531 catalytic residue [active] 1322246003532 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 1322246003533 transcription termination factor Rho; Provisional; Region: rho; PRK09376 1322246003534 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 1322246003535 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 1322246003536 RNA binding site [nucleotide binding]; other site 1322246003537 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 1322246003538 multimer interface [polypeptide binding]; other site 1322246003539 Walker A motif; other site 1322246003540 ATP binding site [chemical binding]; other site 1322246003541 Walker B motif; other site 1322246003542 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 1322246003543 Peptidase family M48; Region: Peptidase_M48; cl12018 1322246003544 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1322246003545 binding surface 1322246003546 TPR motif; other site 1322246003547 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 1322246003548 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1322246003549 active site 1322246003550 Riboflavin kinase; Region: Flavokinase; pfam01687 1322246003551 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1322246003552 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 1322246003553 Cl- selectivity filter; other site 1322246003554 Cl- binding residues [ion binding]; other site 1322246003555 pore gating glutamate residue; other site 1322246003556 dimer interface [polypeptide binding]; other site 1322246003557 FOG: CBS domain [General function prediction only]; Region: COG0517 1322246003558 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc2; cd04613 1322246003559 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 1322246003560 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1322246003561 Walker A motif; other site 1322246003562 ATP binding site [chemical binding]; other site 1322246003563 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 1322246003564 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1322246003565 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 1322246003566 active site 1322246003567 HslU subunit interaction site [polypeptide binding]; other site 1322246003568 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 1322246003569 putative ADP-ribose binding site [chemical binding]; other site 1322246003570 putative active site [active] 1322246003571 Rrf2 family protein; Region: rrf2_super; TIGR00738 1322246003572 Transcriptional regulator; Region: Rrf2; pfam02082 1322246003573 Transcriptional regulator; Region: Rrf2; cl17282 1322246003574 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1322246003575 Cysteine-rich domain; Region: CCG; pfam02754 1322246003576 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959 1322246003577 Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901 1322246003578 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 1322246003579 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 1322246003580 heme-binding residues [chemical binding]; other site 1322246003581 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 1322246003582 heme-binding residues [chemical binding]; other site 1322246003583 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 1322246003584 heme-binding residues [chemical binding]; other site 1322246003585 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 1322246003586 heme-binding residues [chemical binding]; other site 1322246003587 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1322246003588 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1322246003589 dimer interface [polypeptide binding]; other site 1322246003590 phosphorylation site [posttranslational modification] 1322246003591 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1322246003592 ATP binding site [chemical binding]; other site 1322246003593 Mg2+ binding site [ion binding]; other site 1322246003594 G-X-G motif; other site 1322246003595 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491 1322246003596 active site 1 [active] 1322246003597 dimer interface [polypeptide binding]; other site 1322246003598 hexamer interface [polypeptide binding]; other site 1322246003599 active site 2 [active] 1322246003600 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 1322246003601 CoA binding domain; Region: CoA_binding_2; pfam13380 1322246003602 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 1322246003603 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 1322246003604 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 1322246003605 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1322246003606 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 1322246003607 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1322246003608 putative active site pocket [active] 1322246003609 dimerization interface [polypeptide binding]; other site 1322246003610 putative catalytic residue [active] 1322246003611 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 1322246003612 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 1322246003613 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1322246003614 ATP binding site [chemical binding]; other site 1322246003615 putative Mg++ binding site [ion binding]; other site 1322246003616 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1322246003617 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 1322246003618 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1322246003619 AAA domain; Region: AAA_13; pfam13166 1322246003620 HsdM N-terminal domain; Region: HsdM_N; pfam12161 1322246003621 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 1322246003622 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1322246003623 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria and archaea; Region: GIY-YIG_unchar_2; cd10447 1322246003624 GIY-YIG motif/motif A; other site 1322246003625 putative active site [active] 1322246003626 putative metal binding site [ion binding]; other site 1322246003627 Domain of unknown function (DUF4357); Region: DUF4357; pfam14267 1322246003628 Fic/DOC family; Region: Fic; pfam02661 1322246003629 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1322246003630 Sel1-like repeats; Region: SEL1; smart00671 1322246003631 Sel1-like repeats; Region: SEL1; smart00671 1322246003632 Sel1-like repeats; Region: SEL1; smart00671 1322246003633 ROS/MUCR transcriptional regulator protein; Region: ROS_MUCR; pfam05443 1322246003634 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 1322246003635 TM2 domain; Region: TM2; pfam05154 1322246003636 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1322246003637 non-specific DNA binding site [nucleotide binding]; other site 1322246003638 salt bridge; other site 1322246003639 sequence-specific DNA binding site [nucleotide binding]; other site 1322246003640 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1322246003641 active site 1322246003642 DNA binding site [nucleotide binding] 1322246003643 Int/Topo IB signature motif; other site 1322246003644 integrase; Provisional; Region: int; PHA02601 1322246003645 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1322246003646 active site 1322246003647 catalytic residues [active] 1322246003648 DNA binding site [nucleotide binding] 1322246003649 Int/Topo IB signature motif; other site 1322246003650 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 1322246003651 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1322246003652 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1322246003653 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1322246003654 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1322246003655 active site 1322246003656 catalytic tetrad [active] 1322246003657 Uncharacterized enzymes similar to novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like-3; cd12810 1322246003658 catalytic site [active] 1322246003659 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1322246003660 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1322246003661 active site 1322246003662 catalytic tetrad [active] 1322246003663 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 1322246003664 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1322246003665 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1322246003666 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1322246003667 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1322246003668 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1322246003669 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1322246003670 active site 1322246003671 catalytic tetrad [active] 1322246003672 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 1322246003673 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1322246003674 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 1322246003675 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1322246003676 Transposase; Region: HTH_Tnp_1; pfam01527 1322246003677 Integrase core domain; Region: rve; pfam00665 1322246003678 Integrase core domain; Region: rve_3; pfam13683 1322246003679 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1322246003680 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_19; cd08518 1322246003681 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1322246003682 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1322246003683 dimer interface [polypeptide binding]; other site 1322246003684 conserved gate region; other site 1322246003685 putative PBP binding loops; other site 1322246003686 ABC-ATPase subunit interface; other site 1322246003687 nickel transporter permease NikC; Provisional; Region: nikC; PRK10417 1322246003688 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1322246003689 dimer interface [polypeptide binding]; other site 1322246003690 ABC-ATPase subunit interface; other site 1322246003691 putative PBP binding loops; other site 1322246003692 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1322246003693 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1322246003694 Walker A/P-loop; other site 1322246003695 ATP binding site [chemical binding]; other site 1322246003696 Q-loop/lid; other site 1322246003697 ABC transporter signature motif; other site 1322246003698 Walker B; other site 1322246003699 D-loop; other site 1322246003700 H-loop/switch region; other site 1322246003701 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1322246003702 nickel import ATP-binding protein NikE; Region: nickel_nikE; TIGR02769 1322246003703 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1322246003704 Walker A/P-loop; other site 1322246003705 ATP binding site [chemical binding]; other site 1322246003706 Q-loop/lid; other site 1322246003707 ABC transporter signature motif; other site 1322246003708 Walker B; other site 1322246003709 D-loop; other site 1322246003710 H-loop/switch region; other site 1322246003711 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 1322246003712 4Fe-4S binding domain; Region: Fer4_6; pfam12837 1322246003713 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 1322246003714 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 1322246003715 dimer interface [polypeptide binding]; other site 1322246003716 active site 1322246003717 glycine loop; other site 1322246003718 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1322246003719 PAS domain; Region: PAS_9; pfam13426 1322246003720 putative active site [active] 1322246003721 heme pocket [chemical binding]; other site 1322246003722 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1322246003723 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1322246003724 Walker A motif; other site 1322246003725 ATP binding site [chemical binding]; other site 1322246003726 Walker B motif; other site 1322246003727 arginine finger; other site 1322246003728 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1322246003729 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1322246003730 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 1322246003731 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 1322246003732 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 1322246003733 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 1322246003734 DctM-like transporters; Region: DctM; pfam06808 1322246003735 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 1322246003736 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1322246003737 dimerization interface [polypeptide binding]; other site 1322246003738 putative DNA binding site [nucleotide binding]; other site 1322246003739 putative Zn2+ binding site [ion binding]; other site 1322246003740 Predicted permeases [General function prediction only]; Region: COG0701 1322246003741 Thioredoxin domain; Region: Thioredoxin_3; pfam13192 1322246003742 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1322246003743 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1322246003744 catalytic residues [active] 1322246003745 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1322246003746 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1322246003747 dimerization interface [polypeptide binding]; other site 1322246003748 putative DNA binding site [nucleotide binding]; other site 1322246003749 putative Zn2+ binding site [ion binding]; other site 1322246003750 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 1322246003751 arsenical-resistance protein; Region: acr3; TIGR00832 1322246003752 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1322246003753 Low molecular weight phosphatase family; Region: LMWPc; cl00105 1322246003754 active site 1322246003755 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1322246003756 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1322246003757 active site 1322246003758 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 1322246003759 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1322246003760 catalytic loop [active] 1322246003761 iron binding site [ion binding]; other site 1322246003762 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1322246003763 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 1322246003764 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1322246003765 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 1322246003766 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1322246003767 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1322246003768 PAS domain; Region: PAS_9; pfam13426 1322246003769 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1322246003770 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1322246003771 DNA binding residues [nucleotide binding] 1322246003772 dimerization interface [polypeptide binding]; other site 1322246003773 lysine-2,3-aminomutase; Region: lys_2_3_AblA; TIGR03820 1322246003774 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1322246003775 FeS/SAM binding site; other site 1322246003776 Lysine-2,3-aminomutase; Region: LAM_C; pfam12544 1322246003777 putative beta-lysine N-acetyltransferase; Region: GNAT_ablB; TIGR03827 1322246003778 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1322246003779 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1322246003780 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1322246003781 DMSO reductase anchor subunit (DmsC); Region: DmsC; cl17519 1322246003782 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 1322246003783 4Fe-4S binding domain; Region: Fer4; cl02805 1322246003784 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 1322246003785 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 1322246003786 putative [4Fe-4S] binding site [ion binding]; other site 1322246003787 putative molybdopterin cofactor binding site [chemical binding]; other site 1322246003788 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cd02775 1322246003789 Nitrate reductase delta subunit; Region: Nitrate_red_del; pfam02613 1322246003790 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1322246003791 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1322246003792 DNA binding residues [nucleotide binding] 1322246003793 xanthine permease; Region: pbuX; TIGR03173 1322246003794 MoeA_like. This domain is similar to a domain found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. There this domain is presumed to bind molybdopterin. The exact function of this subgroup is...; Region: MoeA_like; cd03522 1322246003795 putative MPT binding site; other site 1322246003796 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 1322246003797 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1322246003798 non-specific DNA binding site [nucleotide binding]; other site 1322246003799 salt bridge; other site 1322246003800 sequence-specific DNA binding site [nucleotide binding]; other site 1322246003801 Cupin domain; Region: Cupin_2; pfam07883 1322246003802 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1322246003803 selenium-dependent molybdenum hydroxylase 1; Region: Se_dep_Molyb_1; TIGR03311 1322246003804 catalytic loop [active] 1322246003805 iron binding site [ion binding]; other site 1322246003806 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1322246003807 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 1322246003808 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1322246003809 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 1322246003810 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 1322246003811 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 1322246003812 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1322246003813 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 1322246003814 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 1322246003815 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1322246003816 Dihydroorotate dehydrogenase [Nucleotide transport and metabolism]; Region: PyrD; COG0167 1322246003817 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 1322246003818 phosphate binding site [ion binding]; other site 1322246003819 4Fe-4S binding domain; Region: Fer4; pfam00037 1322246003820 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 1322246003821 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1322246003822 active site 1322246003823 phenylhydantoinase; Validated; Region: PRK08323 1322246003824 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1322246003825 active site 1322246003826 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 1322246003827 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 1322246003828 active site 1322246003829 putative substrate binding pocket [chemical binding]; other site 1322246003830 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1322246003831 peptidase; Reviewed; Region: PRK13004 1322246003832 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like4; cd05649 1322246003833 putative metal binding site [ion binding]; other site 1322246003834 putative dimer interface [polypeptide binding]; other site 1322246003835 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cd00640 1322246003836 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1322246003837 catalytic residue [active] 1322246003838 PhosphatidylEthanolamine-Binding Protein (PEBP) domain; Region: PEBP; cl00227 1322246003839 substrate binding site [chemical binding]; other site 1322246003840 formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553 1322246003841 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 1322246003842 [4Fe-4S] binding site [ion binding]; other site 1322246003843 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1322246003844 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 1322246003845 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 1322246003846 molybdopterin cofactor binding site; other site 1322246003847 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 1322246003848 Protein involved in formate dehydrogenase formation; Region: FdhE; pfam04216 1322246003849 formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562 1322246003850 FdhD/NarQ family; Region: FdhD-NarQ; pfam02634 1322246003851 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 1322246003852 HPP family; Region: HPP; pfam04982 1322246003853 metallo-beta-lactamase/flavodoxin domain-containing protein; Provisional; Region: PRK11921 1322246003854 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1322246003855 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1322246003856 Domain of unknown function (DUF1858); Region: DUF1858; cl14817 1322246003857 Uncharacterized conserved protein [Function unknown]; Region: COG2461 1322246003858 Family of unknown function (DUF438); Region: DUF438; pfam04282 1322246003859 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 1322246003860 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 1322246003861 glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273 1322246003862 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1322246003863 Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191 1322246003864 Ligand binding site; other site 1322246003865 DXD motif; other site 1322246003866 Lamin Tail Domain; Region: LTD; pfam00932 1322246003867 Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174 1322246003868 CotH protein; Region: CotH; pfam08757 1322246003869 Polyphosphate(polyP) polymerase domain of yeast vacuolar transport chaperone (VTC) proteins VTC-2, -3 and- 4, and similar proteins; Region: PolyPPase_VTC_like; cd07750 1322246003870 putative metal binding residues [ion binding]; other site 1322246003871 signature motif; other site 1322246003872 dimer interface [polypeptide binding]; other site 1322246003873 active site 1322246003874 polyP binding site; other site 1322246003875 substrate binding site [chemical binding]; other site 1322246003876 acceptor-phosphate pocket; other site 1322246003877 Class I aldolases; Region: Aldolase_Class_I; cl17187 1322246003878 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1322246003879 putative cation:proton antiport protein; Provisional; Region: PRK10669 1322246003880 TrkA-N domain; Region: TrkA_N; pfam02254 1322246003881 TrkA-C domain; Region: TrkA_C; pfam02080 1322246003882 periplasmic multidrug efflux lipoprotein precursor; Reviewed; Region: PRK09578 1322246003883 HlyD family secretion protein; Region: HlyD_3; pfam13437 1322246003884 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 1322246003885 Protein export membrane protein; Region: SecD_SecF; cl14618 1322246003886 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1322246003887 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1322246003888 active site 1322246003889 phosphorylation site [posttranslational modification] 1322246003890 intermolecular recognition site; other site 1322246003891 dimerization interface [polypeptide binding]; other site 1322246003892 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1322246003893 DNA binding site [nucleotide binding] 1322246003894 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1322246003895 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1322246003896 dimer interface [polypeptide binding]; other site 1322246003897 phosphorylation site [posttranslational modification] 1322246003898 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1322246003899 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1322246003900 ferrichrome receptor precursor protein; Provisional; Region: PRK14050 1322246003901 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1322246003902 N-terminal plug; other site 1322246003903 ligand-binding site [chemical binding]; other site 1322246003904 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1322246003905 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1322246003906 Walker A/P-loop; other site 1322246003907 ATP binding site [chemical binding]; other site 1322246003908 Q-loop/lid; other site 1322246003909 ABC transporter signature motif; other site 1322246003910 Walker B; other site 1322246003911 D-loop; other site 1322246003912 H-loop/switch region; other site 1322246003913 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1322246003914 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1322246003915 siderophore binding site; other site 1322246003916 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1322246003917 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1322246003918 ABC-ATPase subunit interface; other site 1322246003919 dimer interface [polypeptide binding]; other site 1322246003920 putative PBP binding regions; other site 1322246003921 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1322246003922 ABC-ATPase subunit interface; other site 1322246003923 dimer interface [polypeptide binding]; other site 1322246003924 putative PBP binding regions; other site 1322246003925 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1322246003926 putative transporter; Provisional; Region: PRK12382 1322246003927 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1322246003928 putative substrate translocation pore; other site 1322246003929 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1322246003930 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1322246003931 dimer interface [polypeptide binding]; other site 1322246003932 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1322246003933 catalytic residue [active] 1322246003934 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1322246003935 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 1322246003936 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 1322246003937 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1322246003938 PGAP1-like protein; Region: PGAP1; pfam07819 1322246003939 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1322246003940 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1322246003941 NAD(P) binding site [chemical binding]; other site 1322246003942 Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435 1322246003943 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1322246003944 NAD(P) binding site [chemical binding]; other site 1322246003945 Thioesterase domain; Region: Thioesterase; pfam00975 1322246003946 Phospholipid methyltransferase; Region: PEMT; cl17370 1322246003947 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1322246003948 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1322246003949 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1322246003950 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1322246003951 HlyD family secretion protein; Region: HlyD_3; pfam13437 1322246003952 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1322246003953 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1322246003954 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1322246003955 Walker A/P-loop; other site 1322246003956 ATP binding site [chemical binding]; other site 1322246003957 Q-loop/lid; other site 1322246003958 ABC transporter signature motif; other site 1322246003959 Walker B; other site 1322246003960 D-loop; other site 1322246003961 H-loop/switch region; other site 1322246003962 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1322246003963 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1322246003964 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1322246003965 Walker A/P-loop; other site 1322246003966 ATP binding site [chemical binding]; other site 1322246003967 Q-loop/lid; other site 1322246003968 ABC transporter signature motif; other site 1322246003969 Walker B; other site 1322246003970 D-loop; other site 1322246003971 H-loop/switch region; other site 1322246003972 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1322246003973 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1322246003974 N-terminal plug; other site 1322246003975 ligand-binding site [chemical binding]; other site 1322246003976 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1322246003977 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1322246003978 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 1322246003979 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 1322246003980 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1322246003981 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1322246003982 acyl-activating enzyme (AAE) consensus motif; other site 1322246003983 AMP binding site [chemical binding]; other site 1322246003984 active site 1322246003985 CoA binding site [chemical binding]; other site 1322246003986 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1322246003987 Condensation domain; Region: Condensation; pfam00668 1322246003988 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1322246003989 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1322246003990 acyl-activating enzyme (AAE) consensus motif; other site 1322246003991 AMP binding site [chemical binding]; other site 1322246003992 active site 1322246003993 CoA binding site [chemical binding]; other site 1322246003994 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1322246003995 Thioesterase domain; Region: Thioesterase; pfam00975 1322246003996 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 1322246003997 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 1322246003998 Ligand Binding Site [chemical binding]; other site 1322246003999 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1322246004000 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1322246004001 FtsX-like permease family; Region: FtsX; pfam02687 1322246004002 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1322246004003 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1322246004004 FtsX-like permease family; Region: FtsX; pfam02687 1322246004005 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1322246004006 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1322246004007 Walker A/P-loop; other site 1322246004008 ATP binding site [chemical binding]; other site 1322246004009 Q-loop/lid; other site 1322246004010 ABC transporter signature motif; other site 1322246004011 Walker B; other site 1322246004012 D-loop; other site 1322246004013 H-loop/switch region; other site 1322246004014 Phospholipid methyltransferase; Region: PEMT; cl17370 1322246004015 NapC/NirT cytochrome c family, N-terminal region; Region: Cytochrom_NNT; pfam03264 1322246004016 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 1322246004017 Seven times multi-haem cytochrome CxxCH; Region: Multi-haem_cyto; pfam13447 1322246004018 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 1322246004019 catalytic residue [active] 1322246004020 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1322246004021 Integrase core domain; Region: rve; pfam00665 1322246004022 Integrase core domain; Region: rve_3; pfam13683 1322246004023 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1322246004024 Transposase; Region: HTH_Tnp_1; pfam01527 1322246004025 RTX toxin acyltransferase family; Region: HlyC; pfam02794 1322246004026 AAA-like domain; Region: AAA_10; pfam12846 1322246004027 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375 1322246004028 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1322246004029 Resolvase, N terminal domain; Region: Resolvase; pfam00239 1322246004030 catalytic residues [active] 1322246004031 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1322246004032 DNA-binding interface [nucleotide binding]; DNA binding site 1322246004033 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1322246004034 non-specific DNA binding site [nucleotide binding]; other site 1322246004035 salt bridge; other site 1322246004036 sequence-specific DNA binding site [nucleotide binding]; other site 1322246004037 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 1322246004038 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1322246004039 active site 1322246004040 catalytic residues [active] 1322246004041 DNA binding site [nucleotide binding] 1322246004042 Int/Topo IB signature motif; other site 1322246004043 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1322246004044 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1322246004045 dimer interface [polypeptide binding]; other site 1322246004046 conserved gate region; other site 1322246004047 putative PBP binding loops; other site 1322246004048 ABC-ATPase subunit interface; other site 1322246004049 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1322246004050 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1322246004051 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1322246004052 dimer interface [polypeptide binding]; other site 1322246004053 conserved gate region; other site 1322246004054 putative PBP binding loops; other site 1322246004055 ABC-ATPase subunit interface; other site 1322246004056 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1322246004057 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1322246004058 Coenzyme A binding pocket [chemical binding]; other site 1322246004059 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 1322246004060 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1322246004061 Walker A/P-loop; other site 1322246004062 ATP binding site [chemical binding]; other site 1322246004063 Q-loop/lid; other site 1322246004064 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1322246004065 ABC transporter signature motif; other site 1322246004066 Walker B; other site 1322246004067 D-loop; other site 1322246004068 H-loop/switch region; other site 1322246004069 MarC family integral membrane protein; Region: MarC; cl00919 1322246004070 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1322246004071 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1322246004072 Acyl-ACP thioesterase; Region: Acyl-ACP_TE; pfam01643 1322246004073 active site 2 [active] 1322246004074 active site 1 [active] 1322246004075 Thioesterase-like superfamily; Region: 4HBT_2; pfam13279 1322246004076 active site 2 [active] 1322246004077 active site 1 [active] 1322246004078 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1322246004079 Coenzyme A binding pocket [chemical binding]; other site 1322246004080 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 1322246004081 putative FMN binding site [chemical binding]; other site 1322246004082 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1322246004083 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1322246004084 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 1322246004085 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1322246004086 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 1322246004087 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1322246004088 active site 1322246004089 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 1322246004090 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 1322246004091 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1322246004092 GTPase CgtA; Reviewed; Region: obgE; PRK12299 1322246004093 GTP1/OBG; Region: GTP1_OBG; pfam01018 1322246004094 Obg GTPase; Region: Obg; cd01898 1322246004095 G1 box; other site 1322246004096 GTP/Mg2+ binding site [chemical binding]; other site 1322246004097 Switch I region; other site 1322246004098 G2 box; other site 1322246004099 G3 box; other site 1322246004100 Switch II region; other site 1322246004101 G4 box; other site 1322246004102 G5 box; other site 1322246004103 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 1322246004104 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1322246004105 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1322246004106 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1322246004107 dimerization interface [polypeptide binding]; other site 1322246004108 substrate binding pocket [chemical binding]; other site 1322246004109 gamma-glutamyl kinase; Provisional; Region: PRK05429 1322246004110 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1322246004111 nucleotide binding site [chemical binding]; other site 1322246004112 homotetrameric interface [polypeptide binding]; other site 1322246004113 putative phosphate binding site [ion binding]; other site 1322246004114 putative allosteric binding site; other site 1322246004115 PUA domain; Region: PUA; pfam01472 1322246004116 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1322246004117 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1322246004118 putative substrate translocation pore; other site 1322246004119 Protein of unknown function (DUF1566); Region: DUF1566; pfam07603 1322246004120 Protein of unknown function (DUF1566); Region: DUF1566; pfam07603 1322246004121 Transcriptional regulator PadR-like family; Region: PadR; cl17335 1322246004122 Predicted transcriptional regulators [Transcription]; Region: COG1695 1322246004123 AAK_UMPK-MosAB: This CD includes the alpha and beta subunits of the Mo storage protein (MosA and MosB) which are related to uridine monophosphate kinase (UMPK) enzymes that catalyze the phosphorylation of UMP by ATP, yielding UDP, and playing a key role...; Region: AAK_UMPK-MosAB; cd04255 1322246004124 putative nucleotide binding site [chemical binding]; other site 1322246004125 putative substrate binding site [chemical binding]; other site 1322246004126 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1322246004127 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 1322246004128 homohexameric interface [polypeptide binding]; other site 1322246004129 feedback inhibition sensing region; other site 1322246004130 carbamate kinase; Reviewed; Region: PRK12686 1322246004131 nucleotide binding site [chemical binding]; other site 1322246004132 N-acetyl-L-glutamate binding site [chemical binding]; other site 1322246004133 Hemerythrin; Region: Hemerythrin; cd12107 1322246004134 Fe binding site [ion binding]; other site 1322246004135 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1322246004136 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1322246004137 dimer interface [polypeptide binding]; other site 1322246004138 putative functional site; other site 1322246004139 putative MPT binding site; other site 1322246004140 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 1322246004141 Adenosylhomocysteinase; Provisional; Region: PTZ00075 1322246004142 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 1322246004143 homotetramer interface [polypeptide binding]; other site 1322246004144 ligand binding site [chemical binding]; other site 1322246004145 catalytic site [active] 1322246004146 NAD binding site [chemical binding]; other site 1322246004147 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1322246004148 dimerization interface [polypeptide binding]; other site 1322246004149 putative DNA binding site [nucleotide binding]; other site 1322246004150 putative Zn2+ binding site [ion binding]; other site 1322246004151 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1322246004152 S-adenosylmethionine binding site [chemical binding]; other site 1322246004153 PEGA domain; Region: PEGA; pfam08308 1322246004154 Protein of unknown function (DUF721); Region: DUF721; pfam05258 1322246004155 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 1322246004156 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 1322246004157 NAD(P) binding site [chemical binding]; other site 1322246004158 catalytic residues [active] 1322246004159 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1322246004160 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 1322246004161 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1322246004162 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1322246004163 DNA binding residues [nucleotide binding] 1322246004164 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 1322246004165 Transposase IS200 like; Region: Y1_Tnp; pfam01797 1322246004166 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1322246004167 metal ion-dependent adhesion site (MIDAS); other site 1322246004168 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1322246004169 active site 1322246004170 catalytic residues [active] 1322246004171 DNA binding site [nucleotide binding] 1322246004172 Int/Topo IB signature motif; other site 1322246004173 Fic family protein [Function unknown]; Region: COG3177 1322246004174 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1322246004175 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1322246004176 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1322246004177 UDP-N-acetylglucosamine 4,6-dehydratase; Region: PseB; TIGR03589 1322246004178 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1322246004179 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1322246004180 active site 1322246004181 catalytic tetrad [active] 1322246004182 glutamate-1-semialdehyde 2,1-aminomutase; Provisional; Region: PRK06209 1322246004183 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1322246004184 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1322246004185 catalytic residue [active] 1322246004186 SpsF is a glycosyltrnasferase implicated in the synthesis of the spore coat; Region: GT2_SpsF; cd02518 1322246004187 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1322246004188 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1322246004189 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 1322246004190 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C); Region: NT5C; cl17836 1322246004191 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1322246004192 motif II; other site 1322246004193 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1322246004194 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1322246004195 Coenzyme A binding pocket [chemical binding]; other site 1322246004196 Amidohydrolase; Region: Amidohydro_2; pfam04909 1322246004197 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1322246004198 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1322246004199 S-adenosylmethionine binding site [chemical binding]; other site 1322246004200 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 1322246004201 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 1322246004202 active site 1322246004203 catalytic residues [active] 1322246004204 metal binding site [ion binding]; metal-binding site 1322246004205 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 1322246004206 Sialic acid synthase [Cell envelope biogenesis, outer membrane]; Region: SpsE; COG2089 1322246004207 NeuB family; Region: NeuB; pfam03102 1322246004208 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1322246004209 FeS/SAM binding site; other site 1322246004210 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 1322246004211 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 1322246004212 short chain dehydrogenase; Provisional; Region: PRK12937 1322246004213 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 1322246004214 NADP binding site [chemical binding]; other site 1322246004215 homodimer interface [polypeptide binding]; other site 1322246004216 active site 1322246004217 substrate binding site [chemical binding]; other site 1322246004218 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 1322246004219 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 1322246004220 THF binding site; other site 1322246004221 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1322246004222 substrate binding site [chemical binding]; other site 1322246004223 THF binding site; other site 1322246004224 zinc-binding site [ion binding]; other site 1322246004225 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK08270 1322246004226 ATP cone domain; Region: ATP-cone; pfam03477 1322246004227 Class III ribonucleotide reductase; Region: RNR_III; cd01675 1322246004228 effector binding site; other site 1322246004229 active site 1322246004230 Zn binding site [ion binding]; other site 1322246004231 glycine loop; other site 1322246004232 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1322246004233 active site 1322246004234 Int/Topo IB signature motif; other site 1322246004235 catalytic residues [active] 1322246004236 DNA binding site [nucleotide binding] 1322246004237 TOBE domain; Region: TOBE; cl01440 1322246004238 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 1322246004239 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1322246004240 thiamine ABC transporter, ATP-binding protein; Region: thiQ; TIGR01277 1322246004241 Walker A/P-loop; other site 1322246004242 ATP binding site [chemical binding]; other site 1322246004243 Q-loop/lid; other site 1322246004244 ABC transporter signature motif; other site 1322246004245 Walker B; other site 1322246004246 D-loop; other site 1322246004247 H-loop/switch region; other site 1322246004248 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1322246004249 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1322246004250 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1322246004251 dimer interface [polypeptide binding]; other site 1322246004252 conserved gate region; other site 1322246004253 putative PBP binding loops; other site 1322246004254 ABC-ATPase subunit interface; other site 1322246004255 Domain of unknown function (DUF364); Region: DUF364; pfam04016 1322246004256 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1322246004257 PAS domain S-box; Region: sensory_box; TIGR00229 1322246004258 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1322246004259 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1322246004260 dimer interface [polypeptide binding]; other site 1322246004261 phosphorylation site [posttranslational modification] 1322246004262 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1322246004263 ATP binding site [chemical binding]; other site 1322246004264 Mg2+ binding site [ion binding]; other site 1322246004265 G-X-G motif; other site 1322246004266 Response regulator receiver domain; Region: Response_reg; pfam00072 1322246004267 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1322246004268 active site 1322246004269 phosphorylation site [posttranslational modification] 1322246004270 intermolecular recognition site; other site 1322246004271 dimerization interface [polypeptide binding]; other site 1322246004272 PAS domain S-box; Region: sensory_box; TIGR00229 1322246004273 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1322246004274 putative active site [active] 1322246004275 heme pocket [chemical binding]; other site 1322246004276 PAS domain S-box; Region: sensory_box; TIGR00229 1322246004277 PAS domain; Region: PAS; smart00091 1322246004278 PAS fold; Region: PAS_4; pfam08448 1322246004279 PAS fold; Region: PAS_3; pfam08447 1322246004280 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1322246004281 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1322246004282 metal binding site [ion binding]; metal-binding site 1322246004283 active site 1322246004284 I-site; other site 1322246004285 Glutaredoxin-like domain protein; Region: GlrX_arch; TIGR02187 1322246004286 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1322246004287 Thioredoxin (TRX)-Glutaredoxin (GRX)-like family; composed of archaeal and bacterial proteins that show similarity to both TRX and GRX, including the C-terminal TRX-fold subdomain of Pyrococcus furiosus protein disulfide oxidoreductase (PfPDO). All...; Region: TRX_GRX_like; cd02973 1322246004288 catalytic residues [active] 1322246004289 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1322246004290 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1322246004291 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1322246004292 Protein of unknown function (DUF2971); Region: DUF2971; pfam11185 1322246004293 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 1322246004294 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1322246004295 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1322246004296 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 1322246004297 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 1322246004298 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 1322246004299 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 1322246004300 DctM-like transporters; Region: DctM; pfam06808 1322246004301 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 1322246004302 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 1322246004303 transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283 1322246004304 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 1322246004305 DXD motif; other site 1322246004306 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 1322246004307 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1322246004308 Zn2+ binding site [ion binding]; other site 1322246004309 Mg2+ binding site [ion binding]; other site 1322246004310 Peptidase family M48; Region: Peptidase_M48; pfam01435 1322246004311 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 1322246004312 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 1322246004313 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 1322246004314 putative active site [active] 1322246004315 putative substrate binding site [chemical binding]; other site 1322246004316 putative cosubstrate binding site; other site 1322246004317 catalytic site [active] 1322246004318 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 1322246004319 dimer interface [polypeptide binding]; other site 1322246004320 active site 1322246004321 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 1322246004322 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1322246004323 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1322246004324 ABC-ATPase subunit interface; other site 1322246004325 dimer interface [polypeptide binding]; other site 1322246004326 putative PBP binding regions; other site 1322246004327 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1322246004328 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1322246004329 Rhomboid family; Region: Rhomboid; cl11446 1322246004330 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1322246004331 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 1322246004332 META domain; Region: META; pfam03724 1322246004333 NAD-dependent deacetylase; Provisional; Region: PRK00481 1322246004334 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 1322246004335 NAD+ binding site [chemical binding]; other site 1322246004336 substrate binding site [chemical binding]; other site 1322246004337 Zn binding site [ion binding]; other site 1322246004338 isocitrate dehydrogenase; Validated; Region: PRK06451 1322246004339 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 1322246004340 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 1322246004341 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 1322246004342 putative substrate-binding site; other site 1322246004343 nickel binding site [ion binding]; other site 1322246004344 HupF/HypC family; Region: HupF_HypC; pfam01455 1322246004345 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 1322246004346 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374 1322246004347 Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740 1322246004348 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 1322246004349 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 1322246004350 Flagellin N-methylase; Region: FliB; pfam03692 1322246004351 Isochorismatase family; Region: Isochorismatase; pfam00857 1322246004352 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1322246004353 catalytic triad [active] 1322246004354 conserved cis-peptide bond; other site 1322246004355 Domain of unknown function DUF77; Region: DUF77; pfam01910 1322246004356 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1322246004357 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1322246004358 ligand binding site [chemical binding]; other site 1322246004359 flexible hinge region; other site 1322246004360 hypothetical protein; Provisional; Region: PRK04334 1322246004361 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 1322246004362 Ribonuclease P; Region: Ribonuclease_P; pfam00825 1322246004363 membrane protein insertase; Provisional; Region: PRK01318 1322246004364 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 1322246004365 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 1322246004366 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 1322246004367 G-X-X-G motif; other site 1322246004368 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 1322246004369 RxxxH motif; other site 1322246004370 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 1322246004371 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 1322246004372 trmE is a tRNA modification GTPase; Region: trmE; cd04164 1322246004373 G1 box; other site 1322246004374 GTP/Mg2+ binding site [chemical binding]; other site 1322246004375 Switch I region; other site 1322246004376 G2 box; other site 1322246004377 Switch II region; other site 1322246004378 G3 box; other site 1322246004379 G4 box; other site 1322246004380 G5 box; other site 1322246004381 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 1322246004382 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1322246004383 Coenzyme A binding pocket [chemical binding]; other site 1322246004384 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1322246004385 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1322246004386 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1322246004387 dimer interface [polypeptide binding]; other site 1322246004388 putative CheW interface [polypeptide binding]; other site 1322246004389 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1322246004390 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1322246004391 metal binding site [ion binding]; metal-binding site 1322246004392 active site 1322246004393 I-site; other site 1322246004394 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 1322246004395 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1322246004396 TPR motif; other site 1322246004397 binding surface 1322246004398 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1322246004399 TPR motif; other site 1322246004400 binding surface 1322246004401 pantoate--beta-alanine ligase; Region: panC; TIGR00018 1322246004402 Pantoate-beta-alanine ligase; Region: PanC; cd00560 1322246004403 active site 1322246004404 ATP-binding site [chemical binding]; other site 1322246004405 pantoate-binding site; other site 1322246004406 HXXH motif; other site 1322246004407 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 1322246004408 tetramerization interface [polypeptide binding]; other site 1322246004409 active site 1322246004410 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1322246004411 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1322246004412 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1322246004413 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1322246004414 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1322246004415 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1322246004416 putative DNA binding site [nucleotide binding]; other site 1322246004417 putative Zn2+ binding site [ion binding]; other site 1322246004418 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1322246004419 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1322246004420 S-adenosylmethionine binding site [chemical binding]; other site 1322246004421 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1322246004422 Nitrogen regulatory protein P-II; Region: P-II; pfam00543 1322246004423 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1322246004424 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 1322246004425 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 1322246004426 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 1322246004427 putative active site; other site 1322246004428 catalytic residue [active] 1322246004429 Predicted alternative 3-dehydroquinate synthase [Amino acid transport and metabolism]; Region: COG1465 1322246004430 3-dehydroquinate synthase; Provisional; Region: PRK02290 1322246004431 Chorismate mutase type II; Region: CM_2; pfam01817 1322246004432 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 1322246004433 Prephenate dehydratase; Region: PDT; pfam00800 1322246004434 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 1322246004435 putative L-Phe binding site [chemical binding]; other site 1322246004436 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 1322246004437 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 1322246004438 hinge; other site 1322246004439 active site 1322246004440 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 1322246004441 prephenate dehydrogenase; Provisional; Region: PRK06444 1322246004442 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 1322246004443 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1322246004444 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1322246004445 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 1322246004446 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1322246004447 glutamine binding [chemical binding]; other site 1322246004448 catalytic triad [active] 1322246004449 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 1322246004450 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1322246004451 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1322246004452 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1322246004453 active site 1322246004454 ribulose/triose binding site [chemical binding]; other site 1322246004455 phosphate binding site [ion binding]; other site 1322246004456 substrate (anthranilate) binding pocket [chemical binding]; other site 1322246004457 product (indole) binding pocket [chemical binding]; other site 1322246004458 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 1322246004459 active site 1322246004460 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 1322246004461 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1322246004462 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1322246004463 catalytic residue [active] 1322246004464 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 1322246004465 substrate binding site [chemical binding]; other site 1322246004466 active site 1322246004467 catalytic residues [active] 1322246004468 heterodimer interface [polypeptide binding]; other site 1322246004469 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1322246004470 binding surface 1322246004471 TPR repeat; Region: TPR_11; pfam13414 1322246004472 TPR motif; other site 1322246004473 TPR repeat; Region: TPR_11; pfam13414 1322246004474 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 1322246004475 TadE-like protein; Region: TadE; pfam07811 1322246004476 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 1322246004477 Putative Flp pilus-assembly TadE/G-like; Region: Tad; pfam13400 1322246004478 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1322246004479 TadE-like protein; Region: TadE; pfam07811 1322246004480 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1322246004481 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1322246004482 active site 1322246004483 phosphorylation site [posttranslational modification] 1322246004484 intermolecular recognition site; other site 1322246004485 dimerization interface [polypeptide binding]; other site 1322246004486 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1322246004487 Walker A motif; other site 1322246004488 ATP binding site [chemical binding]; other site 1322246004489 Walker B motif; other site 1322246004490 arginine finger; other site 1322246004491 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1322246004492 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 1322246004493 active site 1322246004494 Flp/Fap pilin component; Region: Flp_Fap; cl01585 1322246004495 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 1322246004496 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 1322246004497 Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745 1322246004498 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 1322246004499 Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964 1322246004500 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 1322246004501 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1322246004502 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1322246004503 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1322246004504 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 1322246004505 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 1322246004506 ATP binding site [chemical binding]; other site 1322246004507 Walker A motif; other site 1322246004508 hexamer interface [polypeptide binding]; other site 1322246004509 Walker B motif; other site 1322246004510 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 1322246004511 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1322246004512 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 1322246004513 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1322246004514 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1322246004515 TPR motif; other site 1322246004516 binding surface 1322246004517 TPR repeat; Region: TPR_11; pfam13414 1322246004518 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1322246004519 TPR motif; other site 1322246004520 binding surface 1322246004521 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1322246004522 binding surface 1322246004523 TPR repeat; Region: TPR_11; pfam13414 1322246004524 TPR motif; other site 1322246004525 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1322246004526 Sporulation related domain; Region: SPOR; pfam05036 1322246004527 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1322246004528 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1322246004529 active site 1322246004530 phosphorylation site [posttranslational modification] 1322246004531 intermolecular recognition site; other site 1322246004532 dimerization interface [polypeptide binding]; other site 1322246004533 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1322246004534 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1322246004535 putative active site [active] 1322246004536 heme pocket [chemical binding]; other site 1322246004537 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1322246004538 dimer interface [polypeptide binding]; other site 1322246004539 phosphorylation site [posttranslational modification] 1322246004540 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1322246004541 ATP binding site [chemical binding]; other site 1322246004542 Mg2+ binding site [ion binding]; other site 1322246004543 G-X-G motif; other site 1322246004544 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1322246004545 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1322246004546 active site 1322246004547 phosphorylation site [posttranslational modification] 1322246004548 intermolecular recognition site; other site 1322246004549 dimerization interface [polypeptide binding]; other site 1322246004550 PAS domain S-box; Region: sensory_box; TIGR00229 1322246004551 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1322246004552 putative active site [active] 1322246004553 heme pocket [chemical binding]; other site 1322246004554 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1322246004555 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1322246004556 dimer interface [polypeptide binding]; other site 1322246004557 phosphorylation site [posttranslational modification] 1322246004558 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1322246004559 ATP binding site [chemical binding]; other site 1322246004560 Mg2+ binding site [ion binding]; other site 1322246004561 G-X-G motif; other site 1322246004562 FIST N domain; Region: FIST; pfam08495 1322246004563 FIST C domain; Region: FIST_C; pfam10442 1322246004564 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 1322246004565 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 1322246004566 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 1322246004567 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 1322246004568 NMT1/THI5 like; Region: NMT1; pfam09084 1322246004569 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 1322246004570 PAS fold; Region: PAS_4; pfam08448 1322246004571 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1322246004572 PAS fold; Region: PAS_4; pfam08448 1322246004573 putative active site [active] 1322246004574 heme pocket [chemical binding]; other site 1322246004575 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1322246004576 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1322246004577 ATP binding site [chemical binding]; other site 1322246004578 Mg2+ binding site [ion binding]; other site 1322246004579 G-X-G motif; other site 1322246004580 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1322246004581 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1322246004582 active site 1322246004583 phosphorylation site [posttranslational modification] 1322246004584 intermolecular recognition site; other site 1322246004585 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 1322246004586 Domain of unknown function (DUF3369); Region: DUF3369; pfam11849 1322246004587 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1322246004588 Zn2+ binding site [ion binding]; other site 1322246004589 Mg2+ binding site [ion binding]; other site 1322246004590 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 1322246004591 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1322246004592 dimerization interface [polypeptide binding]; other site 1322246004593 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1322246004594 PAS domain; Region: PAS_9; pfam13426 1322246004595 putative active site [active] 1322246004596 heme pocket [chemical binding]; other site 1322246004597 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1322246004598 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1322246004599 metal binding site [ion binding]; metal-binding site 1322246004600 active site 1322246004601 I-site; other site 1322246004602 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1322246004603 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 1322246004604 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1322246004605 FeS/SAM binding site; other site 1322246004606 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1322246004607 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cl00399 1322246004608 MoaE homodimer interface [polypeptide binding]; other site 1322246004609 MoaD interaction [polypeptide binding]; other site 1322246004610 active site residues [active] 1322246004611 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 1322246004612 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 1322246004613 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1322246004614 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1322246004615 Domain of unknown function (DUF1956); Region: DUF1956; pfam09209 1322246004616 Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823 1322246004617 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 1322246004618 DEDDy 3'-5' exonuclease domain of WRN and similar proteins; Region: WRN_exo; cd06141 1322246004619 catalytic site [active] 1322246004620 putative active site [active] 1322246004621 putative substrate binding site [chemical binding]; other site 1322246004622 hypothetical protein; Provisional; Region: PRK09256 1322246004623 hypothetical protein; Provisional; Region: PRK01617 1322246004624 SEC-C motif; Region: SEC-C; pfam02810 1322246004625 SEC-C motif; Region: SEC-C; pfam02810 1322246004626 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 1322246004627 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1322246004628 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1322246004629 prolyl-tRNA synthetase; Provisional; Region: PRK09194 1322246004630 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 1322246004631 dimer interface [polypeptide binding]; other site 1322246004632 motif 1; other site 1322246004633 active site 1322246004634 motif 2; other site 1322246004635 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 1322246004636 putative deacylase active site [active] 1322246004637 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1322246004638 active site 1322246004639 motif 3; other site 1322246004640 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 1322246004641 anticodon binding site; other site 1322246004642 HAMP domain; Region: HAMP; pfam00672 1322246004643 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1322246004644 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1322246004645 dimer interface [polypeptide binding]; other site 1322246004646 putative CheW interface [polypeptide binding]; other site 1322246004647 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1322246004648 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1322246004649 substrate binding pocket [chemical binding]; other site 1322246004650 membrane-bound complex binding site; other site 1322246004651 hinge residues; other site 1322246004652 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 1322246004653 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1322246004654 generic binding surface II; other site 1322246004655 generic binding surface I; other site 1322246004656 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1322246004657 Peptidase family M23; Region: Peptidase_M23; pfam01551 1322246004658 Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750 1322246004659 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1322246004660 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1322246004661 substrate binding pocket [chemical binding]; other site 1322246004662 chain length determination region; other site 1322246004663 substrate-Mg2+ binding site; other site 1322246004664 catalytic residues [active] 1322246004665 aspartate-rich region 1; other site 1322246004666 active site lid residues [active] 1322246004667 aspartate-rich region 2; other site 1322246004668 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 1322246004669 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 1322246004670 TPP-binding site; other site 1322246004671 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1322246004672 PYR/PP interface [polypeptide binding]; other site 1322246004673 dimer interface [polypeptide binding]; other site 1322246004674 TPP binding site [chemical binding]; other site 1322246004675 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1322246004676 Plant calmodulin-binding domain; Region: CaM_binding; cl06741 1322246004677 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 1322246004678 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 1322246004679 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 1322246004680 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 1322246004681 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 1322246004682 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 1322246004683 NADH dehydrogenase; Region: NADHdh; cl00469 1322246004684 hydrogenase membrane subunit; Validated; Region: PRK08676 1322246004685 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1322246004686 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1322246004687 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 1322246004688 Active Sites [active] 1322246004689 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1322246004690 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 1322246004691 active site 1322246004692 Zn binding site [ion binding]; other site 1322246004693 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 1322246004694 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1322246004695 SnoaL-like domain; Region: SnoaL_3; pfam13474 1322246004696 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1322246004697 active site 1322246004698 adenylosuccinate lyase; Provisional; Region: PRK07492 1322246004699 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 1322246004700 tetramer interface [polypeptide binding]; other site 1322246004701 active site 1322246004702 Adenylosuccinate lyase C-terminus; Region: ADSL_C; pfam10397 1322246004703 Putative regulatory protein; Region: CxxC_CXXC_SSSS; smart00834 1322246004704 Acylphosphatase; Region: Acylphosphatase; pfam00708 1322246004705 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 1322246004706 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1322246004707 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1322246004708 active site 1322246004709 phosphorylation site [posttranslational modification] 1322246004710 intermolecular recognition site; other site 1322246004711 dimerization interface [polypeptide binding]; other site 1322246004712 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 1322246004713 GAF domain; Region: GAF_3; pfam13492 1322246004714 GAF domain; Region: GAF_2; pfam13185 1322246004715 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1322246004716 Zn2+ binding site [ion binding]; other site 1322246004717 Mg2+ binding site [ion binding]; other site 1322246004718 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1322246004719 Response regulator receiver domain; Region: Response_reg; pfam00072 1322246004720 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1322246004721 active site 1322246004722 phosphorylation site [posttranslational modification] 1322246004723 intermolecular recognition site; other site 1322246004724 dimerization interface [polypeptide binding]; other site 1322246004725 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 1322246004726 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1322246004727 dimerization interface [polypeptide binding]; other site 1322246004728 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1322246004729 dimer interface [polypeptide binding]; other site 1322246004730 phosphorylation site [posttranslational modification] 1322246004731 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1322246004732 ATP binding site [chemical binding]; other site 1322246004733 Mg2+ binding site [ion binding]; other site 1322246004734 G-X-G motif; other site 1322246004735 Response regulator receiver domain; Region: Response_reg; pfam00072 1322246004736 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1322246004737 active site 1322246004738 phosphorylation site [posttranslational modification] 1322246004739 intermolecular recognition site; other site 1322246004740 dimerization interface [polypeptide binding]; other site 1322246004741 glucosamine-fructose-6-phosphate aminotransferase; Provisional; Region: PTZ00394 1322246004742 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cd00352 1322246004743 active site 1322246004744 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1322246004745 dimer interface [polypeptide binding]; other site 1322246004746 active site 1322246004747 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 1322246004748 TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; pfam08722 1322246004749 TnsA endonuclease C terminal; Region: Tn7_Tnp_TnsA_C; pfam08721 1322246004750 Integrase core domain; Region: rve; pfam00665 1322246004751 Integrase core domain; Region: rve_3; pfam13683 1322246004752 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1322246004753 Transposase; Region: HTH_Tnp_1; pfam01527 1322246004754 Colicin D; Region: Colicin_D; pfam11429 1322246004755 Bacterial self-protective colicin-like immunity; Region: Colicin_immun; pfam09204 1322246004756 Integrase core domain; Region: rve; pfam00665 1322246004757 Integrase core domain; Region: rve_3; pfam13683 1322246004758 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1322246004759 Protein of unknown function (DUF2721); Region: DUF2721; pfam11026 1322246004760 Domain of unknown function (DUF3391); Region: DUF3391; pfam11871 1322246004761 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 1322246004762 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1322246004763 Zn2+ binding site [ion binding]; other site 1322246004764 Mg2+ binding site [ion binding]; other site 1322246004765 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1322246004766 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1322246004767 dimer interface [polypeptide binding]; other site 1322246004768 conserved gate region; other site 1322246004769 putative PBP binding loops; other site 1322246004770 ABC-ATPase subunit interface; other site 1322246004771 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 1322246004772 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1322246004773 ABC-ATPase subunit interface; other site 1322246004774 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1322246004775 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1322246004776 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1322246004777 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1322246004778 Walker A/P-loop; other site 1322246004779 ATP binding site [chemical binding]; other site 1322246004780 Q-loop/lid; other site 1322246004781 ABC transporter signature motif; other site 1322246004782 Walker B; other site 1322246004783 D-loop; other site 1322246004784 H-loop/switch region; other site 1322246004785 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 1322246004786 active site 1322246004787 catalytic residues [active] 1322246004788 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1322246004789 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1322246004790 DNA binding site [nucleotide binding] 1322246004791 domain linker motif; other site 1322246004792 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1322246004793 dimerization interface [polypeptide binding]; other site 1322246004794 ligand binding site [chemical binding]; other site 1322246004795 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 1322246004796 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 1322246004797 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1322246004798 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720 1322246004799 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 1322246004800 dimer interface [polypeptide binding]; other site 1322246004801 active site 1322246004802 Protein of unknown function (DUF1255); Region: DUF1255; pfam06865 1322246004803 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1322246004804 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1322246004805 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1322246004806 Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968 1322246004807 Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437 1322246004808 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1322246004809 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1322246004810 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1322246004811 active site 1322246004812 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1322246004813 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1322246004814 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1322246004815 Predicted transcriptional regulator [Transcription]; Region: COG1959 1322246004816 Transcriptional regulator; Region: Rrf2; cl17282 1322246004817 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 1322246004818 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1322246004819 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1322246004820 active site residue [active] 1322246004821 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 1322246004822 Protein of unknown function (DUF1641); Region: DUF1641; pfam07849 1322246004823 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1322246004824 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1322246004825 active site 1322246004826 phosphorylation site [posttranslational modification] 1322246004827 intermolecular recognition site; other site 1322246004828 dimerization interface [polypeptide binding]; other site 1322246004829 Response regulator receiver domain; Region: Response_reg; pfam00072 1322246004830 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1322246004831 active site 1322246004832 phosphorylation site [posttranslational modification] 1322246004833 intermolecular recognition site; other site 1322246004834 dimerization interface [polypeptide binding]; other site 1322246004835 PAS fold; Region: PAS_4; pfam08448 1322246004836 PAS domain; Region: PAS_9; pfam13426 1322246004837 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1322246004838 putative active site [active] 1322246004839 heme pocket [chemical binding]; other site 1322246004840 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1322246004841 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1322246004842 ATP binding site [chemical binding]; other site 1322246004843 Mg2+ binding site [ion binding]; other site 1322246004844 G-X-G motif; other site 1322246004845 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1322246004846 dimerization interface [polypeptide binding]; other site 1322246004847 PAS fold; Region: PAS_4; pfam08448 1322246004848 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1322246004849 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1322246004850 putative active site [active] 1322246004851 heme pocket [chemical binding]; other site 1322246004852 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1322246004853 dimer interface [polypeptide binding]; other site 1322246004854 phosphorylation site [posttranslational modification] 1322246004855 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1322246004856 ATP binding site [chemical binding]; other site 1322246004857 Mg2+ binding site [ion binding]; other site 1322246004858 G-X-G motif; other site 1322246004859 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 1322246004860 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1322246004861 active site residue [active] 1322246004862 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 1322246004863 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1322246004864 dimerization interface [polypeptide binding]; other site 1322246004865 putative ATP binding site [chemical binding]; other site 1322246004866 AmmeMemoRadiSam system radical SAM enzyme; Region: AmmeMemoSam_rS; TIGR04337 1322246004867 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1322246004868 FeS/SAM binding site; other site 1322246004869 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1322246004870 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1322246004871 transmembrane helices; other site 1322246004872 DsrE/DsrF-like family; Region: DrsE; cl00672 1322246004873 uncharacterized bacterial and archaeal solute carrier 6 subfamily; solute-binding domain; Region: SLC6sbd_u1; cd10334 1322246004874 Na2 binding site [ion binding]; other site 1322246004875 putative substrate binding site 1 [chemical binding]; other site 1322246004876 Na binding site 1 [ion binding]; other site 1322246004877 putative substrate binding site 2 [chemical binding]; other site 1322246004878 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1322246004879 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1322246004880 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 1322246004881 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 1322246004882 Transcriptional regulator; Region: Rrf2; cl17282 1322246004883 Rrf2 family protein; Region: rrf2_super; TIGR00738 1322246004884 cobalt transport protein CbiM; Validated; Region: PRK06265 1322246004885 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 1322246004886 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 1322246004887 HD domain; Region: HD_3; pfam13023 1322246004888 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 1322246004889 TRAM domain; Region: TRAM; pfam01938 1322246004890 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1322246004891 S-adenosylmethionine binding site [chemical binding]; other site 1322246004892 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1322246004893 non-specific DNA binding site [nucleotide binding]; other site 1322246004894 salt bridge; other site 1322246004895 sequence-specific DNA binding site [nucleotide binding]; other site 1322246004896 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 1322246004897 CBS domain; Region: CBS; pfam00571 1322246004898 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1322246004899 Zn2+ binding site [ion binding]; other site 1322246004900 Mg2+ binding site [ion binding]; other site 1322246004901 Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469 1322246004902 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1322246004903 domain interfaces; other site 1322246004904 active site 1322246004905 MraZ protein; Region: MraZ; pfam02381 1322246004906 MraW methylase family; Region: Methyltransf_5; pfam01795 1322246004907 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 1322246004908 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1322246004909 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1322246004910 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1322246004911 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 1322246004912 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 1322246004913 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1322246004914 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1322246004915 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1322246004916 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1322246004917 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 1322246004918 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1322246004919 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1322246004920 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 1322246004921 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1322246004922 Mg++ binding site [ion binding]; other site 1322246004923 putative catalytic motif [active] 1322246004924 putative substrate binding site [chemical binding]; other site 1322246004925 UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell envelope biogenesis, outer membrane]; Region: MurD; COG0771 1322246004926 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002 1322246004927 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1322246004928 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1322246004929 cell division protein FtsW; Region: ftsW; TIGR02614 1322246004930 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 1322246004931 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1322246004932 active site 1322246004933 homodimer interface [polypeptide binding]; other site 1322246004934 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1322246004935 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1322246004936 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1322246004937 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1322246004938 UDP-N-acetylmuramate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: MurB; COG0812 1322246004939 FAD binding domain; Region: FAD_binding_4; pfam01565 1322246004940 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1322246004941 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 1322246004942 Cell division protein FtsQ; Region: FtsQ; pfam03799 1322246004943 cell division protein FtsA; Region: ftsA; TIGR01174 1322246004944 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1322246004945 nucleotide binding site [chemical binding]; other site 1322246004946 Cell division protein FtsA; Region: FtsA; pfam14450 1322246004947 cell division protein FtsZ; Validated; Region: PRK09330 1322246004948 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1322246004949 nucleotide binding site [chemical binding]; other site 1322246004950 SulA interaction site; other site 1322246004951 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 1322246004952 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1322246004953 FeS/SAM binding site; other site 1322246004954 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1322246004955 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1322246004956 dimer interface [polypeptide binding]; other site 1322246004957 active site 1322246004958 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1322246004959 folate binding site [chemical binding]; other site 1322246004960 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 1322246004961 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1322246004962 dimer interface [polypeptide binding]; other site 1322246004963 active site 1322246004964 acyl carrier protein; Provisional; Region: acpP; PRK00982 1322246004965 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1322246004966 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1322246004967 NAD(P) binding site [chemical binding]; other site 1322246004968 homotetramer interface [polypeptide binding]; other site 1322246004969 homodimer interface [polypeptide binding]; other site 1322246004970 active site 1322246004971 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 1322246004972 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1322246004973 dimer interface [polypeptide binding]; other site 1322246004974 active site 1322246004975 CoA binding pocket [chemical binding]; other site 1322246004976 putative phosphate acyltransferase; Provisional; Region: PRK05331 1322246004977 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 1322246004978 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1322246004979 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1322246004980 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1322246004981 Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine; Region: Bromodomain; cl02556 1322246004982 acetyllysine binding site; other site 1322246004983 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 1322246004984 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1322246004985 dimerization interface [polypeptide binding]; other site 1322246004986 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1322246004987 putative active site [active] 1322246004988 heme pocket [chemical binding]; other site 1322246004989 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1322246004990 dimer interface [polypeptide binding]; other site 1322246004991 phosphorylation site [posttranslational modification] 1322246004992 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1322246004993 ATP binding site [chemical binding]; other site 1322246004994 Mg2+ binding site [ion binding]; other site 1322246004995 G-X-G motif; other site 1322246004996 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1322246004997 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 1322246004998 active site 1322246004999 HIGH motif; other site 1322246005000 nucleotide binding site [chemical binding]; other site 1322246005001 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1322246005002 active site 1322246005003 KMSKS motif; other site 1322246005004 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 1322246005005 HDOD domain; Region: HDOD; pfam08668 1322246005006 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1322246005007 Zn2+ binding site [ion binding]; other site 1322246005008 Mg2+ binding site [ion binding]; other site 1322246005009 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1322246005010 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1322246005011 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1322246005012 active site 1322246005013 phosphorylation site [posttranslational modification] 1322246005014 intermolecular recognition site; other site 1322246005015 dimerization interface [polypeptide binding]; other site 1322246005016 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1322246005017 Walker A motif; other site 1322246005018 ATP binding site [chemical binding]; other site 1322246005019 Walker B motif; other site 1322246005020 arginine finger; other site 1322246005021 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1322246005022 sensory histidine kinase AtoS; Provisional; Region: PRK11360 1322246005023 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1322246005024 dimer interface [polypeptide binding]; other site 1322246005025 phosphorylation site [posttranslational modification] 1322246005026 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1322246005027 ATP binding site [chemical binding]; other site 1322246005028 Mg2+ binding site [ion binding]; other site 1322246005029 G-X-G motif; other site 1322246005030 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 1322246005031 dimer interface [polypeptide binding]; other site 1322246005032 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1322246005033 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1322246005034 substrate binding pocket [chemical binding]; other site 1322246005035 membrane-bound complex binding site; other site 1322246005036 hinge residues; other site 1322246005037 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 1322246005038 catalytic motif [active] 1322246005039 Zn binding site [ion binding]; other site 1322246005040 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 1322246005041 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 1322246005042 catalytic motif [active] 1322246005043 Zn binding site [ion binding]; other site 1322246005044 RibD C-terminal domain; Region: RibD_C; cl17279 1322246005045 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 1322246005046 Lumazine binding domain; Region: Lum_binding; pfam00677 1322246005047 Lumazine binding domain; Region: Lum_binding; pfam00677 1322246005048 Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936 1322246005049 flavodoxin, short chain; Region: flav_short; TIGR01753 1322246005050 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 1322246005051 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1322246005052 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1322246005053 homodimer interface [polypeptide binding]; other site 1322246005054 catalytic residue [active] 1322246005055 cobyric acid synthase; Provisional; Region: PRK00784 1322246005056 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1322246005057 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1322246005058 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 1322246005059 catalytic triad [active] 1322246005060 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 1322246005061 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1322246005062 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1322246005063 substrate binding pocket [chemical binding]; other site 1322246005064 membrane-bound complex binding site; other site 1322246005065 hinge residues; other site 1322246005066 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1322246005067 Zn2+ binding site [ion binding]; other site 1322246005068 Mg2+ binding site [ion binding]; other site 1322246005069 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 1322246005070 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1322246005071 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1322246005072 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 1322246005073 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1322246005074 dimerization interface [polypeptide binding]; other site 1322246005075 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1322246005076 putative active site [active] 1322246005077 heme pocket [chemical binding]; other site 1322246005078 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1322246005079 dimer interface [polypeptide binding]; other site 1322246005080 phosphorylation site [posttranslational modification] 1322246005081 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1322246005082 ATP binding site [chemical binding]; other site 1322246005083 Mg2+ binding site [ion binding]; other site 1322246005084 G-X-G motif; other site 1322246005085 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 1322246005086 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 1322246005087 active site 1322246005088 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1322246005089 dimer interface [polypeptide binding]; other site 1322246005090 substrate binding site [chemical binding]; other site 1322246005091 catalytic residues [active] 1322246005092 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 1322246005093 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1322246005094 ATP binding site [chemical binding]; other site 1322246005095 Mg2+ binding site [ion binding]; other site 1322246005096 G-X-G motif; other site 1322246005097 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 1322246005098 ATP binding site [chemical binding]; other site 1322246005099 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 1322246005100 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 1322246005101 Organic solvent tolerance protein; Region: OstA_C; pfam04453 1322246005102 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 1322246005103 ADP-L-glycero-D-manno-heptose-6-epimerase; Region: heptose_epim; TIGR02197 1322246005104 NADP binding site [chemical binding]; other site 1322246005105 homopentamer interface [polypeptide binding]; other site 1322246005106 substrate binding site [chemical binding]; other site 1322246005107 active site 1322246005108 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1322246005109 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1322246005110 ligand binding site [chemical binding]; other site 1322246005111 Uncharacterized conserved protein (DUF2196); Region: DUF2196; pfam09962 1322246005112 Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; pfam02639 1322246005113 CHASE domain; Region: CHASE; cl01369 1322246005114 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1322246005115 PAS fold; Region: PAS_3; pfam08447 1322246005116 putative active site [active] 1322246005117 heme pocket [chemical binding]; other site 1322246005118 PAS domain S-box; Region: sensory_box; TIGR00229 1322246005119 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1322246005120 putative active site [active] 1322246005121 heme pocket [chemical binding]; other site 1322246005122 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1322246005123 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1322246005124 metal binding site [ion binding]; metal-binding site 1322246005125 active site 1322246005126 I-site; other site 1322246005127 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 1322246005128 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1322246005129 HlyD family secretion protein; Region: HlyD_3; pfam13437 1322246005130 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 1322246005131 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1322246005132 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1322246005133 Walker A/P-loop; other site 1322246005134 ATP binding site [chemical binding]; other site 1322246005135 Q-loop/lid; other site 1322246005136 ABC transporter signature motif; other site 1322246005137 Walker B; other site 1322246005138 D-loop; other site 1322246005139 H-loop/switch region; other site 1322246005140 type I secretion system ABC transporter, PrtD family; Region: type_I_sec_PrtD; TIGR01842 1322246005141 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1322246005142 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1322246005143 Walker A/P-loop; other site 1322246005144 ATP binding site [chemical binding]; other site 1322246005145 Q-loop/lid; other site 1322246005146 ABC transporter signature motif; other site 1322246005147 Walker B; other site 1322246005148 D-loop; other site 1322246005149 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 1322246005150 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1322246005151 active site 1322246005152 phosphorylation site [posttranslational modification] 1322246005153 intermolecular recognition site; other site 1322246005154 dimerization interface [polypeptide binding]; other site 1322246005155 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1322246005156 Zn2+ binding site [ion binding]; other site 1322246005157 Mg2+ binding site [ion binding]; other site 1322246005158 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1322246005159 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1322246005160 dimer interface [polypeptide binding]; other site 1322246005161 phosphorylation site [posttranslational modification] 1322246005162 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1322246005163 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1322246005164 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1322246005165 active site 1322246005166 phosphorylation site [posttranslational modification] 1322246005167 intermolecular recognition site; other site 1322246005168 dimerization interface [polypeptide binding]; other site 1322246005169 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1322246005170 dimerization interface [polypeptide binding]; other site 1322246005171 PAS domain S-box; Region: sensory_box; TIGR00229 1322246005172 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1322246005173 putative active site [active] 1322246005174 heme pocket [chemical binding]; other site 1322246005175 PAS domain S-box; Region: sensory_box; TIGR00229 1322246005176 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1322246005177 putative active site [active] 1322246005178 heme pocket [chemical binding]; other site 1322246005179 PAS domain S-box; Region: sensory_box; TIGR00229 1322246005180 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1322246005181 putative active site [active] 1322246005182 heme pocket [chemical binding]; other site 1322246005183 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1322246005184 dimer interface [polypeptide binding]; other site 1322246005185 phosphorylation site [posttranslational modification] 1322246005186 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1322246005187 ATP binding site [chemical binding]; other site 1322246005188 Mg2+ binding site [ion binding]; other site 1322246005189 G-X-G motif; other site 1322246005190 metallo-beta-lactamase/flavodoxin domain-containing protein; Provisional; Region: PRK11921 1322246005191 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1322246005192 Flavodoxin; Region: Flavodoxin_1; pfam00258 1322246005193 Desulforedoxin (DSRD) domain; a small non-heme iron domain present in the desulforedoxin (rubredoxin oxidoreductase) and desulfoferrodoxin proteins of some archeael and bacterial methanogens and sulfate/sulfur reducers. Desulforedoxin is a small; Region: DSRD; cd00974 1322246005194 desulfoferrodoxin; Region: dfx_rbo; TIGR00320 1322246005195 non-heme iron binding site [ion binding]; other site 1322246005196 dimer interface [polypeptide binding]; other site 1322246005197 Superoxide reductase-like (SORL) domain, class I; SORL-domains are present in a family of mononuclear non-heme iron proteins that includes superoxide reductase and desulfoferrodoxin. Superoxide reductase-like proteins scavenge superoxide anion radicals...; Region: SORL_Dfx_classI; cd03171 1322246005198 non-heme iron binding site [ion binding]; other site 1322246005199 dimer interface [polypeptide binding]; other site 1322246005200 Rubrerythrin [Energy production and conversion]; Region: COG1592 1322246005201 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 1322246005202 binuclear metal center [ion binding]; other site 1322246005203 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 1322246005204 iron binding site [ion binding]; other site 1322246005205 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1322246005206 metal binding site 2 [ion binding]; metal-binding site 1322246005207 putative DNA binding helix; other site 1322246005208 metal binding site 1 [ion binding]; metal-binding site 1322246005209 dimer interface [polypeptide binding]; other site 1322246005210 structural Zn2+ binding site [ion binding]; other site 1322246005211 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1322246005212 dimerization interface [polypeptide binding]; other site 1322246005213 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1322246005214 PAS domain; Region: PAS_9; pfam13426 1322246005215 putative active site [active] 1322246005216 heme pocket [chemical binding]; other site 1322246005217 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1322246005218 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1322246005219 dimer interface [polypeptide binding]; other site 1322246005220 putative CheW interface [polypeptide binding]; other site 1322246005221 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 1322246005222 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; cl00789 1322246005223 Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain [Nucleotide transport and metabolism]; Region: PurL; COG0046 1322246005224 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1322246005225 dimerization interface [polypeptide binding]; other site 1322246005226 ATP binding site [chemical binding]; other site 1322246005227 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 1322246005228 dimerization interface [polypeptide binding]; other site 1322246005229 ATP binding site [chemical binding]; other site 1322246005230 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1322246005231 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1322246005232 substrate binding pocket [chemical binding]; other site 1322246005233 chain length determination region; other site 1322246005234 substrate-Mg2+ binding site; other site 1322246005235 catalytic residues [active] 1322246005236 aspartate-rich region 1; other site 1322246005237 active site lid residues [active] 1322246005238 aspartate-rich region 2; other site 1322246005239 futalosine nucleosidase; Region: fut_nucase; TIGR03664 1322246005240 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 1322246005241 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1322246005242 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1322246005243 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1322246005244 Uncharacterized protein conserved in bacteria (DUF2065); Region: DUF2065; pfam09838 1322246005245 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 1322246005246 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1322246005247 S-adenosylmethionine binding site [chemical binding]; other site 1322246005248 hypothetical protein; Provisional; Region: PRK10756 1322246005249 CreA protein; Region: CreA; pfam05981 1322246005250 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 1322246005251 DEAD/DEAH box helicase; Region: DEAD; pfam00270 1322246005252 ATP binding site [chemical binding]; other site 1322246005253 putative Mg++ binding site [ion binding]; other site 1322246005254 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1322246005255 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 1322246005256 nucleotide binding region [chemical binding]; other site 1322246005257 ATP-binding site [chemical binding]; other site 1322246005258 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1322246005259 Cysteine-rich domain; Region: CCG; pfam02754 1322246005260 FAD binding domain; Region: FAD_binding_4; pfam01565 1322246005261 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 1322246005262 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1322246005263 SmpB-tmRNA interface; other site 1322246005264 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 1322246005265 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1322246005266 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1322246005267 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1322246005268 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1322246005269 dimerization domain swap beta strand [polypeptide binding]; other site 1322246005270 regulatory protein interface [polypeptide binding]; other site 1322246005271 active site 1322246005272 regulatory phosphorylation site [posttranslational modification]; other site 1322246005273 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 1322246005274 BioY family; Region: BioY; pfam02632 1322246005275 biotin synthase; Region: bioB; TIGR00433 1322246005276 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1322246005277 FeS/SAM binding site; other site 1322246005278 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 1322246005279 Predicted methyltransferases [General function prediction only]; Region: COG0313 1322246005280 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 1322246005281 putative SAM binding site [chemical binding]; other site 1322246005282 putative homodimer interface [polypeptide binding]; other site 1322246005283 hypothetical protein; Reviewed; Region: PRK12497 1322246005284 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1322246005285 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1322246005286 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1322246005287 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1322246005288 RNA/DNA hybrid binding site [nucleotide binding]; other site 1322246005289 active site 1322246005290 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 1322246005291 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1322246005292 SAM-dependent RNA methyltransferase; Region: Methyltrn_RNA_4; pfam09936 1322246005293 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 1322246005294 RimM N-terminal domain; Region: RimM; pfam01782 1322246005295 PRC-barrel domain; Region: PRC; pfam05239 1322246005296 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 1322246005297 hypothetical protein; Provisional; Region: PRK00468 1322246005298 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 1322246005299 signal recognition particle protein; Provisional; Region: PRK10867 1322246005300 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1322246005301 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1322246005302 P loop; other site 1322246005303 GTP binding site [chemical binding]; other site 1322246005304 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1322246005305 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 1322246005306 seryl-tRNA synthetase; Provisional; Region: PRK05431 1322246005307 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1322246005308 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1322246005309 dimer interface [polypeptide binding]; other site 1322246005310 active site 1322246005311 motif 1; other site 1322246005312 motif 2; other site 1322246005313 motif 3; other site 1322246005314 Uncharacterized conserved protein [Function unknown]; Region: COG0397 1322246005315 hypothetical protein; Validated; Region: PRK00029 1322246005316 Phosphotransferase enzyme family; Region: APH; pfam01636 1322246005317 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1322246005318 active site 1322246005319 ATP binding site [chemical binding]; other site 1322246005320 substrate binding site [chemical binding]; other site 1322246005321 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 1322246005322 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1322246005323 NAD(P) binding site [chemical binding]; other site 1322246005324 active site 1322246005325 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1322246005326 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 1322246005327 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1322246005328 homodimer interface [polypeptide binding]; other site 1322246005329 catalytic residue [active] 1322246005330 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 1322246005331 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 1322246005332 active site 1322246005333 putative homodimer interface [polypeptide binding]; other site 1322246005334 SAM binding site [chemical binding]; other site 1322246005335 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 1322246005336 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1322246005337 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 1322246005338 active site 1322246005339 intersubunit interactions; other site 1322246005340 catalytic residue [active] 1322246005341 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 1322246005342 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 1322246005343 atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245 1322246005344 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1322246005345 putative NAD(P) binding site [chemical binding]; other site 1322246005346 putative active site [active] 1322246005347 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 1322246005348 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1322246005349 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1322246005350 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1322246005351 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1322246005352 HAMP domain; Region: HAMP; pfam00672 1322246005353 dimerization interface [polypeptide binding]; other site 1322246005354 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1322246005355 dimer interface [polypeptide binding]; other site 1322246005356 putative CheW interface [polypeptide binding]; other site 1322246005357 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1322246005358 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 1322246005359 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1322246005360 inhibitor-cofactor binding pocket; inhibition site 1322246005361 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1322246005362 catalytic residue [active] 1322246005363 cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788 1322246005364 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 1322246005365 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 1322246005366 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 1322246005367 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 1322246005368 active site 1322246005369 SAM binding site [chemical binding]; other site 1322246005370 homodimer interface [polypeptide binding]; other site 1322246005371 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 1322246005372 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 1322246005373 heme-binding residues [chemical binding]; other site 1322246005374 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 1322246005375 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1322246005376 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 1322246005377 putative NAD(P) binding site [chemical binding]; other site 1322246005378 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1322246005379 membrane-bound complex binding site; other site 1322246005380 hinge residues; other site 1322246005381 conserved hypothetical protein; Region: TIGR02285 1322246005382 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1322246005383 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1322246005384 substrate binding pocket [chemical binding]; other site 1322246005385 membrane-bound complex binding site; other site 1322246005386 hinge residues; other site 1322246005387 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 1322246005388 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 1322246005389 Competence-damaged protein; Region: CinA; pfam02464 1322246005390 Protein of unknown function (DUF3124); Region: DUF3124; pfam11322 1322246005391 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 1322246005392 heterotetramer interface [polypeptide binding]; other site 1322246005393 active site pocket [active] 1322246005394 cleavage site 1322246005395 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 1322246005396 active site 1 [active] 1322246005397 dimer interface [polypeptide binding]; other site 1322246005398 hexamer interface [polypeptide binding]; other site 1322246005399 active site 2 [active] 1322246005400 HD domain; Region: HD_3; pfam13023 1322246005401 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1322246005402 Permease; Region: Permease; pfam02405 1322246005403 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 1322246005404 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 1322246005405 Walker A/P-loop; other site 1322246005406 ATP binding site [chemical binding]; other site 1322246005407 Q-loop/lid; other site 1322246005408 ABC transporter signature motif; other site 1322246005409 Walker B; other site 1322246005410 D-loop; other site 1322246005411 H-loop/switch region; other site 1322246005412 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 1322246005413 mce related protein; Region: MCE; pfam02470 1322246005414 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494 1322246005415 VacJ like lipoprotein; Region: VacJ; cl01073 1322246005416 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 1322246005417 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1322246005418 active site 1322246005419 metal binding site [ion binding]; metal-binding site 1322246005420 homotetramer interface [polypeptide binding]; other site 1322246005421 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 1322246005422 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1322246005423 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1322246005424 active site 1322246005425 dimerization interface [polypeptide binding]; other site 1322246005426 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1322246005427 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1322246005428 putative active site [active] 1322246005429 heme pocket [chemical binding]; other site 1322246005430 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1322246005431 dimer interface [polypeptide binding]; other site 1322246005432 phosphorylation site [posttranslational modification] 1322246005433 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1322246005434 ATP binding site [chemical binding]; other site 1322246005435 Mg2+ binding site [ion binding]; other site 1322246005436 G-X-G motif; other site 1322246005437 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 1322246005438 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1322246005439 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1322246005440 FeS/SAM binding site; other site 1322246005441 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 1322246005442 active site 1322246005443 catalytic site [active] 1322246005444 substrate binding site [chemical binding]; other site 1322246005445 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1322246005446 FAD binding domain; Region: FAD_binding_4; pfam01565 1322246005447 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1322246005448 Cysteine-rich domain; Region: CCG; pfam02754 1322246005449 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 1322246005450 Diphthamide biosynthesis methyltransferase [Translation, ribosomal structure and biogenesis]; Region: DPH5; COG1798 1322246005451 active site 1322246005452 SAM binding site [chemical binding]; other site 1322246005453 homodimer interface [polypeptide binding]; other site 1322246005454 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1322246005455 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1322246005456 substrate binding pocket [chemical binding]; other site 1322246005457 membrane-bound complex binding site; other site 1322246005458 hinge residues; other site 1322246005459 Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894 1322246005460 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1322246005461 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1322246005462 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1322246005463 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1322246005464 dimerization interface 3.5A [polypeptide binding]; other site 1322246005465 active site 1322246005466 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 1322246005467 Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023 1322246005468 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1322246005469 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1322246005470 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1322246005471 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1322246005472 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1322246005473 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 1322246005474 putative active site [active] 1322246005475 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1322246005476 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1322246005477 S-adenosylmethionine binding site [chemical binding]; other site 1322246005478 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain [Amino acid transport and metabolism / Signal transduction mechanisms]; Region: HisJ; COG0834 1322246005479 CRP/FNR family transcriptional regulator; Provisional; Region: PRK13918 1322246005480 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1322246005481 ligand binding site [chemical binding]; other site 1322246005482 flexible hinge region; other site 1322246005483 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1322246005484 putative switch regulator; other site 1322246005485 non-specific DNA interactions [nucleotide binding]; other site 1322246005486 DNA binding site [nucleotide binding] 1322246005487 sequence specific DNA binding site [nucleotide binding]; other site 1322246005488 putative cAMP binding site [chemical binding]; other site 1322246005489 Carbon monoxide dehydrogenase (CODH) is found in acetogenic and methanogenic organisms and is responsible for the synthesis and breakdown of acetyl-CoA, respectively. CODH has two types of metal clusters, a cubane [Fe4-S4] center (B-cluster) similar to...; Region: CODH; cd01915 1322246005490 ACS interaction site; other site 1322246005491 CODH interaction site; other site 1322246005492 Prismane/CO dehydrogenase family; Region: Prismane; pfam03063 1322246005493 cubane metal cluster (B-cluster) [ion binding]; other site 1322246005494 Ni-Fe-S cluster (C-cluster) [ion binding]; other site 1322246005495 The accessory protein CooC, which contains a nucleotide-binding domain (P-loop) near the N-terminus, participates in the maturation of the nickel center of carbon monoxide dehydrogenase (CODH). CODH from Rhodospirillum rubrum catalyzes the reversible...; Region: CooC; cd02034 1322246005496 P-loop; other site 1322246005497 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1322246005498 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1322246005499 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1322246005500 substrate binding pocket [chemical binding]; other site 1322246005501 membrane-bound complex binding site; other site 1322246005502 hinge residues; other site 1322246005503 Uncharacterized conserved protein [Function unknown]; Region: COG0432 1322246005504 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1322246005505 dimer interface [polypeptide binding]; other site 1322246005506 phosphorylation site [posttranslational modification] 1322246005507 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1322246005508 ATP binding site [chemical binding]; other site 1322246005509 Mg2+ binding site [ion binding]; other site 1322246005510 G-X-G motif; other site 1322246005511 Response regulator receiver domain; Region: Response_reg; pfam00072 1322246005512 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1322246005513 active site 1322246005514 phosphorylation site [posttranslational modification] 1322246005515 intermolecular recognition site; other site 1322246005516 dimerization interface [polypeptide binding]; other site 1322246005517 Hpt domain; Region: Hpt; pfam01627 1322246005518 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1322246005519 PAS domain; Region: PAS_9; pfam13426 1322246005520 putative active site [active] 1322246005521 heme pocket [chemical binding]; other site 1322246005522 PAS domain; Region: PAS_9; pfam13426 1322246005523 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1322246005524 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1322246005525 dimer interface [polypeptide binding]; other site 1322246005526 phosphorylation site [posttranslational modification] 1322246005527 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1322246005528 ATP binding site [chemical binding]; other site 1322246005529 Mg2+ binding site [ion binding]; other site 1322246005530 G-X-G motif; other site 1322246005531 Predicted transcriptional regulators [Transcription]; Region: COG1733 1322246005532 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1322246005533 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 1322246005534 putative FMN binding site [chemical binding]; other site 1322246005535 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 1322246005536 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1322246005537 CHASE domain; Region: CHASE; cl01369 1322246005538 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1322246005539 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1322246005540 putative active site [active] 1322246005541 heme pocket [chemical binding]; other site 1322246005542 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1322246005543 putative active site [active] 1322246005544 heme pocket [chemical binding]; other site 1322246005545 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1322246005546 dimer interface [polypeptide binding]; other site 1322246005547 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1322246005548 phosphorylation site [posttranslational modification] 1322246005549 Histidine kinase-like ATPases; Region: HATPase_c; smart00387 1322246005550 Zinc dependent phospholipase C; Region: Zn_dep_PLPC; pfam00882 1322246005551 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 1322246005552 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1322246005553 Zn2+ binding site [ion binding]; other site 1322246005554 Mg2+ binding site [ion binding]; other site 1322246005555 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1322246005556 NmrA-like family; Region: NmrA; pfam05368 1322246005557 NAD(P) binding site [chemical binding]; other site 1322246005558 active site 1322246005559 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1322246005560 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1322246005561 S-adenosylmethionine binding site [chemical binding]; other site 1322246005562 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 1322246005563 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 1322246005564 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1322246005565 active site residue [active] 1322246005566 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1322246005567 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 1322246005568 UbiA prenyltransferase family; Region: UbiA; pfam01040 1322246005569 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 1322246005570 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 1322246005571 PHP domain; Region: PHP; pfam02811 1322246005572 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 1322246005573 active site 1322246005574 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1322246005575 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 1322246005576 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 1322246005577 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 1322246005578 active site 1322246005579 HIGH motif; other site 1322246005580 nucleotide binding site [chemical binding]; other site 1322246005581 Flagellin N-methylase; Region: FliB; pfam03692 1322246005582 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 1322246005583 Predicted phosphoesterases, related to the Icc protein [General function prediction only]; Region: COG2129 1322246005584 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1322246005585 active site 1322246005586 metal binding site [ion binding]; metal-binding site 1322246005587 Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738 1322246005588 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 1322246005589 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1322246005590 Zn2+ binding site [ion binding]; other site 1322246005591 Mg2+ binding site [ion binding]; other site 1322246005592 PAS fold; Region: PAS_4; pfam08448 1322246005593 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1322246005594 putative active site [active] 1322246005595 heme pocket [chemical binding]; other site 1322246005596 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1322246005597 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1322246005598 dimer interface [polypeptide binding]; other site 1322246005599 putative CheW interface [polypeptide binding]; other site 1322246005600 Sporulation related domain; Region: SPOR; pfam05036 1322246005601 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 1322246005602 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 1322246005603 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1322246005604 active site 1322246005605 HIGH motif; other site 1322246005606 KMSK motif region; other site 1322246005607 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1322246005608 tRNA binding surface [nucleotide binding]; other site 1322246005609 anticodon binding site; other site 1322246005610 cytidylate kinase; Provisional; Region: cmk; PRK00023 1322246005611 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1322246005612 CMP-binding site; other site 1322246005613 The sites determining sugar specificity; other site 1322246005614 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 1322246005615 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1322246005616 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1322246005617 homodimer interface [polypeptide binding]; other site 1322246005618 catalytic residue [active] 1322246005619 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1322246005620 Ligand Binding Site [chemical binding]; other site 1322246005621 Class II flagellar assembly regulator; Region: FliX; cl11677 1322246005622 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1322246005623 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1322246005624 Walker A/P-loop; other site 1322246005625 ATP binding site [chemical binding]; other site 1322246005626 Q-loop/lid; other site 1322246005627 ABC transporter signature motif; other site 1322246005628 Walker B; other site 1322246005629 D-loop; other site 1322246005630 H-loop/switch region; other site 1322246005631 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1322246005632 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1322246005633 TM-ABC transporter signature motif; other site 1322246005634 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1322246005635 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1322246005636 TM-ABC transporter signature motif; other site 1322246005637 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1322246005638 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 1322246005639 dimerization interface [polypeptide binding]; other site 1322246005640 ligand binding site [chemical binding]; other site 1322246005641 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1322246005642 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1322246005643 Walker A/P-loop; other site 1322246005644 ATP binding site [chemical binding]; other site 1322246005645 Q-loop/lid; other site 1322246005646 ABC transporter signature motif; other site 1322246005647 Walker B; other site 1322246005648 D-loop; other site 1322246005649 H-loop/switch region; other site 1322246005650 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 1322246005651 malonic semialdehyde reductase; Provisional; Region: PRK10538 1322246005652 putative NAD(P) binding site [chemical binding]; other site 1322246005653 homotetramer interface [polypeptide binding]; other site 1322246005654 homodimer interface [polypeptide binding]; other site 1322246005655 active site 1322246005656 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 1322246005657 heme-binding site [chemical binding]; other site 1322246005658 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1322246005659 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1322246005660 metal binding site [ion binding]; metal-binding site 1322246005661 active site 1322246005662 I-site; other site 1322246005663 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1322246005664 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 1322246005665 Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148 1322246005666 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1322246005667 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 1322246005668 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 1322246005669 Methyl-viologen-reducing hydrogenase, delta subunit; Region: FlpD; pfam02662 1322246005670 Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148 1322246005671 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1322246005672 adenosine phosphosulphate reductase, alpha subunit; Region: aprA; TIGR02061 1322246005673 adenosine phosphosulphate reductase, beta subunit; Region: aprB; TIGR02060 1322246005674 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 1322246005675 Adenosine-5'-phosphosulfate reductase beta subunit; Region: APS-reductase_C; pfam12139 1322246005676 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 1322246005677 ATP-sulfurylase; Region: ATPS; cd00517 1322246005678 active site 1322246005679 HXXH motif; other site 1322246005680 flexible loop; other site 1322246005681 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1322246005682 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1322246005683 Coenzyme A binding pocket [chemical binding]; other site 1322246005684 Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u4; cd10928 1322246005685 NodB motif; other site 1322246005686 putative active site [active] 1322246005687 putative catalytic site [active] 1322246005688 putative Zn binding site [ion binding]; other site 1322246005689 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1322246005690 Radical SAM superfamily; Region: Radical_SAM; pfam04055 1322246005691 FeS/SAM binding site; other site 1322246005692 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1322246005693 NlpC/P60 family; Region: NLPC_P60; cl17555 1322246005694 Predicted glycosyl transferase [General function prediction only]; Region: COG4671 1322246005695 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1322246005696 colanic acid biosynthesis glycosyltransferase WcaL; Region: wcaL; TIGR04005 1322246005697 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 1322246005698 putative ADP-binding pocket [chemical binding]; other site 1322246005699 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14184 1322246005700 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1322246005701 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1322246005702 homodimer interface [polypeptide binding]; other site 1322246005703 NADP binding site [chemical binding]; other site 1322246005704 substrate binding site [chemical binding]; other site 1322246005705 enolase; Provisional; Region: eno; PRK00077 1322246005706 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1322246005707 dimer interface [polypeptide binding]; other site 1322246005708 metal binding site [ion binding]; metal-binding site 1322246005709 substrate binding pocket [chemical binding]; other site 1322246005710 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1322246005711 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1322246005712 dimerization interface [polypeptide binding]; other site 1322246005713 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1322246005714 dimer interface [polypeptide binding]; other site 1322246005715 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1322246005716 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1322246005717 dimer interface [polypeptide binding]; other site 1322246005718 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 1322246005719 putative CheW interface [polypeptide binding]; other site 1322246005720 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1322246005721 nucleotide binding site [chemical binding]; other site 1322246005722 Type III pantothenate kinase; Region: Pan_kinase; cl17198 1322246005723 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1322246005724 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1322246005725 dimerization interface [polypeptide binding]; other site 1322246005726 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1322246005727 dimer interface [polypeptide binding]; other site 1322246005728 putative CheW interface [polypeptide binding]; other site 1322246005729 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 1322246005730 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1322246005731 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 1322246005732 heme-binding residues [chemical binding]; other site 1322246005733 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 1322246005734 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1322246005735 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1322246005736 active site 1322246005737 HIGH motif; other site 1322246005738 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1322246005739 KMSKS motif; other site 1322246005740 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1322246005741 tRNA binding surface [nucleotide binding]; other site 1322246005742 anticodon binding site; other site 1322246005743 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1322246005744 bifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase protein; Provisional; Region: ispDF; PRK09382 1322246005745 substrate binding site; other site 1322246005746 dimer interface; other site 1322246005747 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 1322246005748 homotrimer interaction site [polypeptide binding]; other site 1322246005749 zinc binding site [ion binding]; other site 1322246005750 CDP-binding sites; other site 1322246005751 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 1322246005752 Putative zinc ribbon domain; Region: DUF164; pfam02591 1322246005753 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1322246005754 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1322246005755 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1322246005756 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 1322246005757 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1322246005758 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1322246005759 Zn2+ binding site [ion binding]; other site 1322246005760 Mg2+ binding site [ion binding]; other site 1322246005761 Predicted permeases [General function prediction only]; Region: COG0701 1322246005762 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1322246005763 putative DNA binding site [nucleotide binding]; other site 1322246005764 putative Zn2+ binding site [ion binding]; other site 1322246005765 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1322246005766 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1322246005767 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1322246005768 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1322246005769 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1322246005770 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2350 1322246005771 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 1322246005772 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII; cd09992 1322246005773 active site 1322246005774 Zn binding site [ion binding]; other site 1322246005775 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 1322246005776 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 1322246005777 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 1322246005778 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1322246005779 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1322246005780 putative active site [active] 1322246005781 Chorismate mutase type II; Region: CM_2; smart00830 1322246005782 3-phosphoshikimate 1-carboxyvinyltransferase; Region: aroA; TIGR01356 1322246005783 aconitate hydratase; Validated; Region: PRK07229 1322246005784 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 1322246005785 substrate binding site [chemical binding]; other site 1322246005786 ligand binding site [chemical binding]; other site 1322246005787 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 1322246005788 substrate binding site [chemical binding]; other site 1322246005789 SurA N-terminal domain; Region: SurA_N_3; cl07813 1322246005790 periplasmic folding chaperone; Provisional; Region: PRK10788 1322246005791 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1322246005792 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 1322246005793 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 1322246005794 active site 1322246005795 NAD binding site [chemical binding]; other site 1322246005796 metal binding site [ion binding]; metal-binding site 1322246005797 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1322246005798 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1322246005799 putative active site [active] 1322246005800 heme pocket [chemical binding]; other site 1322246005801 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1322246005802 dimer interface [polypeptide binding]; other site 1322246005803 phosphorylation site [posttranslational modification] 1322246005804 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1322246005805 ATP binding site [chemical binding]; other site 1322246005806 Mg2+ binding site [ion binding]; other site 1322246005807 G-X-G motif; other site 1322246005808 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1322246005809 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1322246005810 active site 1322246005811 phosphorylation site [posttranslational modification] 1322246005812 intermolecular recognition site; other site 1322246005813 dimerization interface [polypeptide binding]; other site 1322246005814 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1322246005815 Walker A motif; other site 1322246005816 ATP binding site [chemical binding]; other site 1322246005817 Walker B motif; other site 1322246005818 arginine finger; other site 1322246005819 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1322246005820 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 1322246005821 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 1322246005822 dimer interface [polypeptide binding]; other site 1322246005823 active site 1322246005824 metal binding site [ion binding]; metal-binding site 1322246005825 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1322246005826 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 1322246005827 Heterodisulfide reductase, subunit B [Energy production and conversion]; Region: HdrB; COG2048 1322246005828 Cysteine-rich domain; Region: CCG; pfam02754 1322246005829 Cysteine-rich domain; Region: CCG; pfam02754 1322246005830 Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148 1322246005831 4Fe-4S binding domain; Region: Fer4; pfam00037 1322246005832 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1322246005833 4Fe-4S binding domain; Region: Fer4_6; pfam12837 1322246005834 Methyl-viologen-reducing hydrogenase, delta subunit; Region: FlpD; pfam02662 1322246005835 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432 1322246005836 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 1322246005837 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1322246005838 sulfite reductase, subunit A; Region: sulfite_red_A; TIGR02910 1322246005839 cytochrome-c3 hydrogenase subunit gamma; Provisional; Region: PRK08345 1322246005840 Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221 1322246005841 FAD binding pocket [chemical binding]; other site 1322246005842 FAD binding motif [chemical binding]; other site 1322246005843 phosphate binding motif [ion binding]; other site 1322246005844 beta-alpha-beta structure motif; other site 1322246005845 NAD binding pocket [chemical binding]; other site 1322246005846 Iron coordination center [ion binding]; other site 1322246005847 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045 1322246005848 diiron binding motif [ion binding]; other site 1322246005849 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; smart00790 1322246005850 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 1322246005851 Aspartate oxidase [Coenzyme metabolism]; Region: NadB; COG0029 1322246005852 L-aspartate oxidase; Provisional; Region: PRK06175 1322246005853 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1322246005854 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 1322246005855 catalytic residues [active] 1322246005856 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1322246005857 catalytic core [active] 1322246005858 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 1322246005859 Ligand binding site; other site 1322246005860 metal-binding site 1322246005861 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1322246005862 Zn2+ binding site [ion binding]; other site 1322246005863 Mg2+ binding site [ion binding]; other site 1322246005864 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 1322246005865 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 1322246005866 XdhC Rossmann domain; Region: XdhC_C; pfam13478 1322246005867 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 1322246005868 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1322246005869 acyl-activating enzyme (AAE) consensus motif; other site 1322246005870 active site 1322246005871 AMP binding site [chemical binding]; other site 1322246005872 CoA binding site [chemical binding]; other site 1322246005873 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1322246005874 Radical SAM superfamily; Region: Radical_SAM; pfam04055 1322246005875 FeS/SAM binding site; other site 1322246005876 Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; pfam09719 1322246005877 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1322246005878 S-adenosylmethionine binding site [chemical binding]; other site 1322246005879 3-hydroxyanthranilic acid dioxygenase; Region: 3-HAO; cl17399 1322246005880 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1322246005881 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 1322246005882 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1322246005883 Cysteine-rich domain; Region: CCG; pfam02754 1322246005884 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 1322246005885 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1322246005886 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 1322246005887 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; pfam01315 1322246005888 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1322246005889 MoeA_like. This domain is similar to a domain found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. There this domain is presumed to bind molybdopterin. The exact function of this subgroup is...; Region: MoeA_like; cd03522 1322246005890 putative MPT binding site; other site 1322246005891 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1322246005892 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1322246005893 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1322246005894 catalytic residue [active] 1322246005895 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1322246005896 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1322246005897 DNA-binding site [nucleotide binding]; DNA binding site 1322246005898 FCD domain; Region: FCD; pfam07729 1322246005899 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1322246005900 S-adenosylmethionine binding site [chemical binding]; other site 1322246005901 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1322246005902 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1322246005903 protein binding site [polypeptide binding]; other site 1322246005904 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1322246005905 heat shock protein HtpX; Provisional; Region: PRK03982 1322246005906 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1322246005907 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1322246005908 substrate binding pocket [chemical binding]; other site 1322246005909 membrane-bound complex binding site; other site 1322246005910 hinge residues; other site 1322246005911 diphosphate--fructose-6-phosphate 1-phosphotransferase; Provisional; Region: PRK06830 1322246005912 6-phosphofructokinase; Region: PLN02884 1322246005913 active site 1322246005914 ADP/pyrophosphate binding site [chemical binding]; other site 1322246005915 dimerization interface [polypeptide binding]; other site 1322246005916 allosteric effector site; other site 1322246005917 fructose-1,6-bisphosphate binding site; other site 1322246005918 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 1322246005919 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1322246005920 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1322246005921 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 1322246005922 TRAP-type mannitol/chloroaromatic compound transport system, large permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT3; COG4664 1322246005923 DctM-like transporters; Region: DctM; pfam06808 1322246005924 UbiA prenyltransferase family; Region: UbiA; pfam01040 1322246005925 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 1322246005926 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 1322246005927 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1322246005928 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1322246005929 Cytochrome c; Region: Cytochrom_C; pfam00034 1322246005930 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 1322246005931 NorE_like subfamily of heme-copper oxidase subunit III. Heme-copper oxidases include cytochrome c and ubiquinol oxidases. Alcaligenes faecalis norE is found in a gene cluster containing norCB. norCB encodes the cytochrome c and cytochrome b subunits of...; Region: NorE_like; cd02862 1322246005932 Subunit I/III interface [polypeptide binding]; other site 1322246005933 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1322246005934 cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891 1322246005935 pentapeptide MXKDX repeat protein; Region: penta_MxKDx; TIGR02953 1322246005936 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 1322246005937 Cu(I) binding site [ion binding]; other site 1322246005938 Cytochrome c; Region: Cytochrom_C; cl11414 1322246005939 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 1322246005940 Ca2+ binding site [ion binding]; other site 1322246005941 TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663 1322246005942 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 1322246005943 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 1322246005944 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1322246005945 Catalytic site [active] 1322246005946 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 1322246005947 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 1322246005948 active site 1322246005949 DNA binding site [nucleotide binding] 1322246005950 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 1322246005951 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 1322246005952 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1322246005953 DNA binding site [nucleotide binding] 1322246005954 active site 1322246005955 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1322246005956 anti sigma factor interaction site; other site 1322246005957 regulatory phosphorylation site [posttranslational modification]; other site 1322246005958 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1322246005959 Cache domain; Region: Cache_1; pfam02743 1322246005960 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1322246005961 dimerization interface [polypeptide binding]; other site 1322246005962 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 1322246005963 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1322246005964 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1322246005965 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1322246005966 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1322246005967 Walker A/P-loop; other site 1322246005968 ATP binding site [chemical binding]; other site 1322246005969 Q-loop/lid; other site 1322246005970 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1322246005971 ABC transporter signature motif; other site 1322246005972 Walker B; other site 1322246005973 D-loop; other site 1322246005974 H-loop/switch region; other site 1322246005975 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cd01635 1322246005976 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1322246005977 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 1322246005978 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1322246005979 active site 1322246005980 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1322246005981 putative catalytic site [active] 1322246005982 putative metal binding site [ion binding]; other site 1322246005983 putative phosphate binding site [ion binding]; other site 1322246005984 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1322246005985 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 1322246005986 conserved cys residue [active] 1322246005987 HI0933-like protein; Region: HI0933_like; pfam03486 1322246005988 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1322246005989 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1322246005990 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1322246005991 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1322246005992 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1322246005993 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1322246005994 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 1322246005995 AzlC protein; Region: AzlC; pfam03591 1322246005996 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1322246005997 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1322246005998 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1322246005999 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1322246006000 homodimer interface [polypeptide binding]; other site 1322246006001 catalytic residue [active] 1322246006002 DNA repair protein RadA; Provisional; Region: PRK11823 1322246006003 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1322246006004 Walker A motif; other site 1322246006005 ATP binding site [chemical binding]; other site 1322246006006 Walker B motif; other site 1322246006007 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1322246006008 dimer interface [polypeptide binding]; other site 1322246006009 active site 1322246006010 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1322246006011 dimer interface [polypeptide binding]; other site 1322246006012 active site 1322246006013 sensor protein ZraS; Provisional; Region: PRK10364 1322246006014 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1322246006015 dimer interface [polypeptide binding]; other site 1322246006016 phosphorylation site [posttranslational modification] 1322246006017 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1322246006018 ATP binding site [chemical binding]; other site 1322246006019 Mg2+ binding site [ion binding]; other site 1322246006020 G-X-G motif; other site 1322246006021 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1322246006022 flagellin; Provisional; Region: PRK12804 1322246006023 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1322246006024 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1322246006025 ribonuclease III; Reviewed; Region: rnc; PRK00102 1322246006026 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1322246006027 dimerization interface [polypeptide binding]; other site 1322246006028 active site 1322246006029 metal binding site [ion binding]; metal-binding site 1322246006030 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1322246006031 dsRNA binding site [nucleotide binding]; other site 1322246006032 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 1322246006033 CoA binding domain; Region: CoA_binding_2; pfam13380 1322246006034 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 1322246006035 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 1322246006036 BioD-like N-terminal domain of phosphotransacetylase [General function prediction only]; Region: Pta; COG0857 1322246006037 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 1322246006038 DRTGG domain; Region: DRTGG; pfam07085 1322246006039 Proline dehydrogenase; Region: Pro_dh; cl03282 1322246006040 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1322246006041 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1322246006042 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1322246006043 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1322246006044 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_5; cd13145 1322246006045 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 1322246006046 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 1322246006047 active site 1322246006048 substrate binding site [chemical binding]; other site 1322246006049 cosubstrate binding site; other site 1322246006050 catalytic site [active] 1322246006051 C-20 methyltransferase BchU; Region: C20_methyl_CrtF; TIGR02716 1322246006052 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1322246006053 S-adenosylmethionine binding site [chemical binding]; other site 1322246006054 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1322246006055 active site 1322246006056 SAM binding site [chemical binding]; other site 1322246006057 homodimer interface [polypeptide binding]; other site 1322246006058 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 1322246006059 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1322246006060 active site 1322246006061 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 1322246006062 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1322246006063 active site 1322246006064 HIGH motif; other site 1322246006065 nucleotide binding site [chemical binding]; other site 1322246006066 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1322246006067 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1322246006068 active site 1322246006069 KMSKS motif; other site 1322246006070 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1322246006071 tRNA binding surface [nucleotide binding]; other site 1322246006072 anticodon binding site; other site 1322246006073 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 1322246006074 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1322246006075 conserved cys residue [active] 1322246006076 Protein of unknown function (DUF342); Region: DUF342; pfam03961 1322246006077 Domain of unknown function (DUF4389); Region: DUF4389; pfam14333 1322246006078 Cysteine-rich small domain; Region: zf-like; cl00946 1322246006079 cysteinyl-tRNA synthetase; Provisional; Region: cysS; PRK14534 1322246006080 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 1322246006081 Domain of unknown function (DUF3391); Region: DUF3391; pfam11871 1322246006082 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1322246006083 Zn2+ binding site [ion binding]; other site 1322246006084 Mg2+ binding site [ion binding]; other site 1322246006085 Flagellar protein YcgR; Region: YcgR_2; pfam12945 1322246006086 PilZ domain; Region: PilZ; pfam07238 1322246006087 AMMECR1; Region: AMMECR1; pfam01871 1322246006088 AmmeMemoRadiSam system protein A; Region: AmmeMemoSam_A; TIGR04335 1322246006089 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 1322246006090 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1322246006091 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 1322246006092 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 1322246006093 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 1322246006094 catalytic triad [active] 1322246006095 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1322246006096 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1322246006097 binding surface 1322246006098 TPR motif; other site 1322246006099 TPR repeat; Region: TPR_11; pfam13414 1322246006100 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 1322246006101 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1322246006102 dimerization interface [polypeptide binding]; other site 1322246006103 PAS domain S-box; Region: sensory_box; TIGR00229 1322246006104 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1322246006105 putative active site [active] 1322246006106 heme pocket [chemical binding]; other site 1322246006107 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1322246006108 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1322246006109 metal binding site [ion binding]; metal-binding site 1322246006110 active site 1322246006111 I-site; other site 1322246006112 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1322246006113 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1322246006114 Type I periplasmic binding domain of uncharacterized extracellular ligand-binding proteins; Region: PBP1_STKc_like; cd06326 1322246006115 putative ligand binding site [chemical binding]; other site 1322246006116 DNA polymerase IV; Validated; Region: PRK02406 1322246006117 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1322246006118 active site 1322246006119 DNA binding site [nucleotide binding] 1322246006120 Uncharacterized conserved protein [Function unknown]; Region: COG3334 1322246006121 cupin fold metalloprotein, WbuC family; Region: cupin_WbuC; TIGR04366 1322246006122 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1322246006123 EamA-like transporter family; Region: EamA; pfam00892 1322246006124 EamA-like transporter family; Region: EamA; pfam00892 1322246006125 EamA-like transporter family; Region: EamA; pfam00892 1322246006126 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1322246006127 EamA-like transporter family; Region: EamA; cl17759 1322246006128 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 1322246006129 HDOD domain; Region: HDOD; pfam08668 1322246006130 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1322246006131 Zn2+ binding site [ion binding]; other site 1322246006132 Mg2+ binding site [ion binding]; other site 1322246006133 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1322246006134 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 1322246006135 Zn binding site [ion binding]; other site 1322246006136 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 1322246006137 Predicted GTPase [General function prediction only]; Region: COG2403 1322246006138 ornithine--oxo-acid transaminase; Reviewed; Region: rocD; PRK00854 1322246006139 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1322246006140 inhibitor-cofactor binding pocket; inhibition site 1322246006141 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1322246006142 catalytic residue [active] 1322246006143 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1322246006144 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1322246006145 DNA-binding site [nucleotide binding]; DNA binding site 1322246006146 FCD domain; Region: FCD; pfam07729 1322246006147 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1322246006148 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1322246006149 putative active site [active] 1322246006150 heme pocket [chemical binding]; other site 1322246006151 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1322246006152 putative active site [active] 1322246006153 heme pocket [chemical binding]; other site 1322246006154 PAS domain S-box; Region: sensory_box; TIGR00229 1322246006155 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1322246006156 putative active site [active] 1322246006157 heme pocket [chemical binding]; other site 1322246006158 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1322246006159 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1322246006160 putative active site [active] 1322246006161 heme pocket [chemical binding]; other site 1322246006162 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1322246006163 heme pocket [chemical binding]; other site 1322246006164 putative active site [active] 1322246006165 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1322246006166 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1322246006167 dimer interface [polypeptide binding]; other site 1322246006168 phosphorylation site [posttranslational modification] 1322246006169 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1322246006170 ATP binding site [chemical binding]; other site 1322246006171 Mg2+ binding site [ion binding]; other site 1322246006172 G-X-G motif; other site 1322246006173 Response regulator receiver domain; Region: Response_reg; pfam00072 1322246006174 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1322246006175 active site 1322246006176 phosphorylation site [posttranslational modification] 1322246006177 intermolecular recognition site; other site 1322246006178 dimerization interface [polypeptide binding]; other site 1322246006179 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 1322246006180 dimerization interface [polypeptide binding]; other site 1322246006181 putative ATP binding site [chemical binding]; other site 1322246006182 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 1322246006183 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1322246006184 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1322246006185 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1322246006186 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1322246006187 catalytic residue [active] 1322246006188 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1322246006189 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1322246006190 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1322246006191 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1322246006192 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1322246006193 Protoporphyrinogen oxidase [Coenzyme metabolism]; Region: HemY; COG1232 1322246006194 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1322246006195 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1322246006196 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1322246006197 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1322246006198 active site 1322246006199 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 1322246006200 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1322246006201 molybdopterin cofactor binding site; other site 1322246006202 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 1322246006203 molybdopterin cofactor binding site; other site 1322246006204 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 1322246006205 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1322246006206 dimer interface [polypeptide binding]; other site 1322246006207 motif 1; other site 1322246006208 active site 1322246006209 motif 2; other site 1322246006210 motif 3; other site 1322246006211 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1322246006212 anticodon binding site; other site 1322246006213 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1322246006214 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1322246006215 dimer interface [polypeptide binding]; other site 1322246006216 anticodon binding site; other site 1322246006217 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1322246006218 homodimer interface [polypeptide binding]; other site 1322246006219 motif 1; other site 1322246006220 active site 1322246006221 motif 2; other site 1322246006222 GAD domain; Region: GAD; pfam02938 1322246006223 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1322246006224 active site 1322246006225 motif 3; other site 1322246006226 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1322246006227 active site 1322246006228 catalytic residues [active] 1322246006229 metal binding site [ion binding]; metal-binding site 1322246006230 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1322246006231 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1322246006232 putative active site [active] 1322246006233 substrate binding site [chemical binding]; other site 1322246006234 putative cosubstrate binding site; other site 1322246006235 catalytic site [active] 1322246006236 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1322246006237 substrate binding site [chemical binding]; other site 1322246006238 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1322246006239 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1322246006240 putative active site [active] 1322246006241 Protein of unknown function DUF116; Region: DUF116; pfam01976 1322246006242 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1322246006243 Amidohydrolase; Region: Amidohydro_4; pfam13147 1322246006244 active site 1322246006245 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 1322246006246 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1322246006247 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1322246006248 dihydroorotase; Validated; Region: pyrC; PRK09357 1322246006249 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 1322246006250 active site 1322246006251 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1322246006252 Zn2+ binding site [ion binding]; other site 1322246006253 Mg2+ binding site [ion binding]; other site 1322246006254 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 1322246006255 Protein of unknown function (DUF1566); Region: DUF1566; pfam07603 1322246006256 Protein of unknown function (DUF1566); Region: DUF1566; pfam07603 1322246006257 putative oxidoreductase; Provisional; Region: PRK12831 1322246006258 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1322246006259 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1322246006260 ferredoxin-NADP(+) reductase subunit alpha; Reviewed; Region: PRK06222 1322246006261 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)...; Region: DHOD_e_trans_like1; cd06219 1322246006262 FAD binding pocket [chemical binding]; other site 1322246006263 FAD binding motif [chemical binding]; other site 1322246006264 phosphate binding motif [ion binding]; other site 1322246006265 beta-alpha-beta structure motif; other site 1322246006266 NAD binding pocket [chemical binding]; other site 1322246006267 Iron coordination center [ion binding]; other site 1322246006268 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1322246006269 metal-binding site [ion binding] 1322246006270 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1322246006271 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1322246006272 metal-binding site [ion binding] 1322246006273 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1322246006274 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1322246006275 motif II; other site 1322246006276 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1322246006277 metal-binding site [ion binding] 1322246006278 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 1322246006279 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1322246006280 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1322246006281 putative transporter; Provisional; Region: PRK11021 1322246006282 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1322246006283 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1322246006284 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1322246006285 dimerization interface [polypeptide binding]; other site 1322246006286 Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u4; cd10928 1322246006287 NodB motif; other site 1322246006288 putative active site [active] 1322246006289 putative catalytic site [active] 1322246006290 putative Zn binding site [ion binding]; other site 1322246006291 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 1322246006292 FtsX-like permease family; Region: FtsX; pfam02687 1322246006293 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1322246006294 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1322246006295 Walker A/P-loop; other site 1322246006296 ATP binding site [chemical binding]; other site 1322246006297 Q-loop/lid; other site 1322246006298 ABC transporter signature motif; other site 1322246006299 Walker B; other site 1322246006300 D-loop; other site 1322246006301 H-loop/switch region; other site 1322246006302 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1322246006303 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1322246006304 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1322246006305 FtsX-like permease family; Region: FtsX; pfam02687 1322246006306 DNA topoisomerase I; Validated; Region: PRK06599 1322246006307 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1322246006308 active site 1322246006309 interdomain interaction site; other site 1322246006310 putative metal-binding site [ion binding]; other site 1322246006311 nucleotide binding site [chemical binding]; other site 1322246006312 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1322246006313 domain I; other site 1322246006314 DNA binding groove [nucleotide binding] 1322246006315 phosphate binding site [ion binding]; other site 1322246006316 domain II; other site 1322246006317 domain III; other site 1322246006318 nucleotide binding site [chemical binding]; other site 1322246006319 catalytic site [active] 1322246006320 domain IV; other site 1322246006321 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1322246006322 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1322246006323 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1322246006324 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1322246006325 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1322246006326 active site 1322246006327 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1322246006328 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1322246006329 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1322246006330 active site 1322246006331 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 1322246006332 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1322246006333 catalytic residue [active] 1322246006334 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 1322246006335 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 1322246006336 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 1322246006337 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 1322246006338 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1322246006339 ligand binding site [chemical binding]; other site 1322246006340 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 1322246006341 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1322246006342 ligand binding site [chemical binding]; other site 1322246006343 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 1322246006344 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 1322246006345 flagellar motor switch protein; Validated; Region: fliN; PRK05698 1322246006346 Flagellar biosynthesis protein, FliO; Region: FliO; pfam04347 1322246006347 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 1322246006348 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 1322246006349 AAA domain; Region: AAA_32; pfam13654 1322246006350 Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067 1322246006351 Uncharacterized conserved protein [Function unknown]; Region: COG2006 1322246006352 Domain of unknown function (DUF362); Region: DUF362; pfam04015 1322246006353 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1322246006354 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 1322246006355 putative ADP-binding pocket [chemical binding]; other site 1322246006356 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1322246006357 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1322246006358 Ligand Binding Site [chemical binding]; other site 1322246006359 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1322246006360 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1322246006361 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1322246006362 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 1322246006363 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1322246006364 ATP binding site [chemical binding]; other site 1322246006365 putative Mg++ binding site [ion binding]; other site 1322246006366 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1322246006367 nucleotide binding region [chemical binding]; other site 1322246006368 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 1322246006369 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 1322246006370 Response regulator receiver domain; Region: Response_reg; pfam00072 1322246006371 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1322246006372 active site 1322246006373 phosphorylation site [posttranslational modification] 1322246006374 intermolecular recognition site; other site 1322246006375 dimerization interface [polypeptide binding]; other site 1322246006376 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 1322246006377 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1322246006378 active site 1322246006379 phosphorylation site [posttranslational modification] 1322246006380 intermolecular recognition site; other site 1322246006381 dimerization interface [polypeptide binding]; other site 1322246006382 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1322246006383 Zn2+ binding site [ion binding]; other site 1322246006384 Mg2+ binding site [ion binding]; other site 1322246006385 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 1322246006386 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 1322246006387 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1322246006388 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1322246006389 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1322246006390 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1322246006391 S-adenosylmethionine binding site [chemical binding]; other site 1322246006392 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1322246006393 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1322246006394 active site 1322246006395 phosphorylation site [posttranslational modification] 1322246006396 intermolecular recognition site; other site 1322246006397 dimerization interface [polypeptide binding]; other site 1322246006398 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1322246006399 Walker A motif; other site 1322246006400 ATP binding site [chemical binding]; other site 1322246006401 Walker B motif; other site 1322246006402 arginine finger; other site 1322246006403 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1322246006404 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 1322246006405 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 1322246006406 putative NAD(P) binding site [chemical binding]; other site 1322246006407 putative active site [active] 1322246006408 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1322246006409 dimerization interface [polypeptide binding]; other site 1322246006410 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1322246006411 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1322246006412 putative active site [active] 1322246006413 heme pocket [chemical binding]; other site 1322246006414 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1322246006415 dimer interface [polypeptide binding]; other site 1322246006416 phosphorylation site [posttranslational modification] 1322246006417 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1322246006418 ATP binding site [chemical binding]; other site 1322246006419 Mg2+ binding site [ion binding]; other site 1322246006420 G-X-G motif; other site 1322246006421 Domain of unknown function (DUF4390); Region: DUF4390; pfam14334 1322246006422 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1322246006423 Ligand Binding Site [chemical binding]; other site 1322246006424 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1322246006425 Ligand Binding Site [chemical binding]; other site 1322246006426 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 1322246006427 MOSC domain; Region: MOSC; pfam03473 1322246006428 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 1322246006429 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 1322246006430 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 1322246006431 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 1322246006432 RNA binding site [nucleotide binding]; other site 1322246006433 DsrE/DsrF-like family; Region: DrsE; pfam02635 1322246006434 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 1322246006435 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374 1322246006436 Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740 1322246006437 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 1322246006438 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1322246006439 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1322246006440 active site 1322246006441 phosphorylation site [posttranslational modification] 1322246006442 intermolecular recognition site; other site 1322246006443 dimerization interface [polypeptide binding]; other site 1322246006444 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1322246006445 Walker A motif; other site 1322246006446 ATP binding site [chemical binding]; other site 1322246006447 Walker B motif; other site 1322246006448 arginine finger; other site 1322246006449 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 1322246006450 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 1322246006451 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1322246006452 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1322246006453 dimer interface [polypeptide binding]; other site 1322246006454 phosphorylation site [posttranslational modification] 1322246006455 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1322246006456 ATP binding site [chemical binding]; other site 1322246006457 Mg2+ binding site [ion binding]; other site 1322246006458 G-X-G motif; other site 1322246006459 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 1322246006460 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1322246006461 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1322246006462 substrate binding site [chemical binding]; other site 1322246006463 activation loop (A-loop); other site 1322246006464 Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414 1322246006465 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; smart00790 1322246006466 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 1322246006467 4Fe-4S binding domain; Region: Fer4; cl02805 1322246006468 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 1322246006469 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1322246006470 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1322246006471 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1322246006472 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1322246006473 metal binding site [ion binding]; metal-binding site 1322246006474 active site 1322246006475 I-site; other site 1322246006476 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 1322246006477 FtsX-like permease family; Region: FtsX; pfam02687 1322246006478 cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673 1322246006479 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1322246006480 Walker A/P-loop; other site 1322246006481 ATP binding site [chemical binding]; other site 1322246006482 Q-loop/lid; other site 1322246006483 ABC transporter signature motif; other site 1322246006484 Walker B; other site 1322246006485 D-loop; other site 1322246006486 H-loop/switch region; other site 1322246006487 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 1322246006488 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1322246006489 active site 1322246006490 phosphorylation site [posttranslational modification] 1322246006491 intermolecular recognition site; other site 1322246006492 dimerization interface [polypeptide binding]; other site 1322246006493 LytTr DNA-binding domain; Region: LytTR; smart00850 1322246006494 acetyl-CoA synthetase; Provisional; Region: PRK00174 1322246006495 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 1322246006496 active site 1322246006497 CoA binding site [chemical binding]; other site 1322246006498 acyl-activating enzyme (AAE) consensus motif; other site 1322246006499 AMP binding site [chemical binding]; other site 1322246006500 acetate binding site [chemical binding]; other site 1322246006501 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1322246006502 Radical SAM superfamily; Region: Radical_SAM; pfam04055 1322246006503 FeS/SAM binding site; other site 1322246006504 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 1322246006505 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 1322246006506 NAD binding site [chemical binding]; other site 1322246006507 homodimer interface [polypeptide binding]; other site 1322246006508 active site 1322246006509 substrate binding site [chemical binding]; other site 1322246006510 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 1322246006511 active site 1322246006512 dimer interface [polypeptide binding]; other site 1322246006513 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1322246006514 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1322246006515 NAD(P) binding site [chemical binding]; other site 1322246006516 active site 1322246006517 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1322246006518 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1322246006519 active site 1322246006520 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1322246006521 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1322246006522 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1322246006523 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 1322246006524 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1322246006525 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1322246006526 S-adenosylmethionine binding site [chemical binding]; other site 1322246006527 Cephalosporin hydroxylase; Region: CmcI; pfam04989 1322246006528 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1322246006529 FeS/SAM binding site; other site 1322246006530 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 1322246006531 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 1322246006532 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1322246006533 active site 1322246006534 nucleotide binding site [chemical binding]; other site 1322246006535 HIGH motif; other site 1322246006536 KMSKS motif; other site 1322246006537 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 1322246006538 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1322246006539 active site 1322246006540 dimer interface [polypeptide binding]; other site 1322246006541 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1322246006542 Ligand Binding Site [chemical binding]; other site 1322246006543 Molecular Tunnel; other site 1322246006544 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 1322246006545 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 1322246006546 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 1322246006547 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 1322246006548 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1322246006549 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1322246006550 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1322246006551 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1322246006552 Methyltransferase domain; Region: Methyltransf_11; pfam08241 1322246006553 B12 binding domain; Region: B12-binding; pfam02310 1322246006554 B12 binding site [chemical binding]; other site 1322246006555 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1322246006556 Radical SAM superfamily; Region: Radical_SAM; pfam04055 1322246006557 FeS/SAM binding site; other site 1322246006558 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 1322246006559 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1322246006560 active site 1322246006561 histidinol-phosphate phosphatase family domain; Region: Histidinol-ppas; TIGR01656 1322246006562 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1322246006563 active site 1322246006564 motif I; other site 1322246006565 motif II; other site 1322246006566 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1322246006567 extended (e) SDRs; Region: SDR_e; cd08946 1322246006568 NAD(P) binding site [chemical binding]; other site 1322246006569 active site 1322246006570 substrate binding site [chemical binding]; other site 1322246006571 Putative zinc binding domain; Region: Methyltransf_13; pfam08421 1322246006572 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1322246006573 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1322246006574 S-adenosylmethionine binding site [chemical binding]; other site 1322246006575 C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484 1322246006576 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 1322246006577 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1322246006578 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1322246006579 NAD(P) binding site [chemical binding]; other site 1322246006580 active site 1322246006581 Predicted kinase related to galactokinase and mevalonate kinase [General function prediction only]; Region: COG2605 1322246006582 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1322246006583 Methyltransferase domain; Region: Methyltransf_11; pfam08241 1322246006584 C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484 1322246006585 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 1322246006586 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1322246006587 FeS/SAM binding site; other site 1322246006588 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1322246006589 FeS/SAM binding site; other site 1322246006590 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 1322246006591 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 1322246006592 ligand binding site; other site 1322246006593 tetramer interface; other site 1322246006594 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1322246006595 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1322246006596 active site 1322246006597 Protein of unknown function DUF115; Region: MAF_flag10; pfam01973 1322246006598 NAD synthetase; Provisional; Region: PRK13981 1322246006599 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 1322246006600 multimer interface [polypeptide binding]; other site 1322246006601 active site 1322246006602 catalytic triad [active] 1322246006603 protein interface 1 [polypeptide binding]; other site 1322246006604 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1322246006605 homodimer interface [polypeptide binding]; other site 1322246006606 NAD binding pocket [chemical binding]; other site 1322246006607 ATP binding pocket [chemical binding]; other site 1322246006608 Mg binding site [ion binding]; other site 1322246006609 active-site loop [active] 1322246006610 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 1322246006611 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1322246006612 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 1322246006613 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 1322246006614 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1322246006615 PAS fold; Region: PAS_3; pfam08447 1322246006616 putative active site [active] 1322246006617 heme pocket [chemical binding]; other site 1322246006618 PAS domain S-box; Region: sensory_box; TIGR00229 1322246006619 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1322246006620 putative active site [active] 1322246006621 heme pocket [chemical binding]; other site 1322246006622 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 1322246006623 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1322246006624 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1322246006625 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1322246006626 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 1322246006627 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 1322246006628 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 1322246006629 Helix-turn-helix domain; Region: HTH_28; pfam13518 1322246006630 Winged helix-turn helix; Region: HTH_29; pfam13551 1322246006631 Integrase core domain; Region: rve; pfam00665 1322246006632 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 1322246006633 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1322246006634 AAA domain; Region: AAA_22; pfam13401 1322246006635 Walker A motif; other site 1322246006636 ATP binding site [chemical binding]; other site 1322246006637 Walker B motif; other site 1322246006638 arginine finger; other site 1322246006639 SIR2-like domain; Region: SIR2_2; pfam13289 1322246006640 Domain of unknown function DUF87; Region: DUF87; pfam01935 1322246006641 Domain of unknown function DUF87; Region: DUF87; pfam01935 1322246006642 HerA helicase [Replication, recombination, and repair]; Region: COG0433 1322246006643 KTSC domain; Region: KTSC; pfam13619 1322246006644 WYL domain; Region: WYL; pfam13280 1322246006645 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 1322246006646 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1322246006647 putative catalytic site [active] 1322246006648 putative metal binding site [ion binding]; other site 1322246006649 putative phosphate binding site [ion binding]; other site 1322246006650 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 1322246006651 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1322246006652 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1322246006653 Walker A motif; other site 1322246006654 ATP binding site [chemical binding]; other site 1322246006655 Protein of unknown function (DUF3568); Region: DUF3568; pfam12092 1322246006656 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1322246006657 DNA binding residues [nucleotide binding] 1322246006658 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 1322246006659 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1322246006660 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 1322246006661 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1322246006662 AIR carboxylase; Region: AIRC; pfam00731 1322246006663 Aminotransferase class IV; Region: Aminotran_4; pfam01063 1322246006664 Rubrerythrin [Energy production and conversion]; Region: COG1592 1322246006665 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 1322246006666 binuclear metal center [ion binding]; other site 1322246006667 Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cl00202 1322246006668 iron binding site [ion binding]; other site 1322246006669 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1322246006670 S-adenosylmethionine binding site [chemical binding]; other site 1322246006671 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1322246006672 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1322246006673 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1322246006674 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1322246006675 dimerization interface [polypeptide binding]; other site 1322246006676 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1322246006677 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1322246006678 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1322246006679 catalytic core [active] 1322246006680 Predicted glycosyl transferase [General function prediction only]; Region: COG4671 1322246006681 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1322246006682 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 1322246006683 FAD binding site [chemical binding]; other site 1322246006684 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1322246006685 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838 1322246006686 active site 1322246006687 metal binding site [ion binding]; metal-binding site 1322246006688 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 1322246006689 putative homodimer interface [polypeptide binding]; other site 1322246006690 putative homotetramer interface [polypeptide binding]; other site 1322246006691 putative allosteric switch controlling residues; other site 1322246006692 putative metal binding site [ion binding]; other site 1322246006693 putative homodimer-homodimer interface [polypeptide binding]; other site 1322246006694 EF-hand domain pair; Region: EF_hand_5; pfam13499 1322246006695 Ca2+ binding site [ion binding]; other site 1322246006696 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 1322246006697 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1322246006698 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1322246006699 substrate binding pocket [chemical binding]; other site 1322246006700 membrane-bound complex binding site; other site 1322246006701 hinge residues; other site 1322246006702 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1322246006703 PAS fold; Region: PAS_3; pfam08447 1322246006704 putative active site [active] 1322246006705 heme pocket [chemical binding]; other site 1322246006706 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1322246006707 dimer interface [polypeptide binding]; other site 1322246006708 phosphorylation site [posttranslational modification] 1322246006709 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1322246006710 ATP binding site [chemical binding]; other site 1322246006711 Mg2+ binding site [ion binding]; other site 1322246006712 G-X-G motif; other site 1322246006713 Response regulator receiver domain; Region: Response_reg; pfam00072 1322246006714 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1322246006715 active site 1322246006716 phosphorylation site [posttranslational modification] 1322246006717 intermolecular recognition site; other site 1322246006718 dimerization interface [polypeptide binding]; other site 1322246006719 GTPase Era; Reviewed; Region: era; PRK00089 1322246006720 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1322246006721 G1 box; other site 1322246006722 GTP/Mg2+ binding site [chemical binding]; other site 1322246006723 Switch I region; other site 1322246006724 G2 box; other site 1322246006725 Switch II region; other site 1322246006726 G3 box; other site 1322246006727 G4 box; other site 1322246006728 G5 box; other site 1322246006729 KH domain; Region: KH_2; pfam07650 1322246006730 G-X-X-G motif; other site 1322246006731 Domain of unknown function (DUF1992); Region: DUF1992; cl08096 1322246006732 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1322246006733 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 1322246006734 active site 1322246006735 phosphorylation site [posttranslational modification] 1322246006736 intermolecular recognition site; other site 1322246006737 dimerization interface [polypeptide binding]; other site 1322246006738 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1322246006739 Walker A motif; other site 1322246006740 ATP binding site [chemical binding]; other site 1322246006741 Walker B motif; other site 1322246006742 arginine finger; other site 1322246006743 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1322246006744 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 1322246006745 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1322246006746 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1322246006747 dimer interface [polypeptide binding]; other site 1322246006748 putative CheW interface [polypeptide binding]; other site 1322246006749 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 1322246006750 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 1322246006751 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1322246006752 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1322246006753 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1322246006754 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1322246006755 active site 1322246006756 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 1322246006757 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1322246006758 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1322246006759 active site 1322246006760 phosphorylation site [posttranslational modification] 1322246006761 intermolecular recognition site; other site 1322246006762 dimerization interface [polypeptide binding]; other site 1322246006763 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1322246006764 Walker A motif; other site 1322246006765 ATP binding site [chemical binding]; other site 1322246006766 Walker B motif; other site 1322246006767 arginine finger; other site 1322246006768 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1322246006769 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 1322246006770 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 1322246006771 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 1322246006772 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 1322246006773 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 1322246006774 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1322246006775 FeS/SAM binding site; other site 1322246006776 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 1322246006777 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 1322246006778 NAD binding site [chemical binding]; other site 1322246006779 homotetramer interface [polypeptide binding]; other site 1322246006780 homodimer interface [polypeptide binding]; other site 1322246006781 substrate binding site [chemical binding]; other site 1322246006782 active site 1322246006783 Uncharacterized Fe-S center protein [General function prediction only]; Region: COG2768 1322246006784 Uncharacterized conserved protein [Function unknown]; Region: COG2006 1322246006785 4Fe-4S binding domain; Region: Fer4; pfam00037 1322246006786 Cache domain; Region: Cache_1; pfam02743 1322246006787 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1322246006788 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1322246006789 dimerization interface [polypeptide binding]; other site 1322246006790 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1322246006791 dimer interface [polypeptide binding]; other site 1322246006792 putative CheW interface [polypeptide binding]; other site 1322246006793 Domain of unknown function (DUF3391); Region: DUF3391; pfam11871 1322246006794 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 1322246006795 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1322246006796 Zn2+ binding site [ion binding]; other site 1322246006797 Mg2+ binding site [ion binding]; other site 1322246006798 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1322246006799 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1322246006800 active site 1322246006801 motif I; other site 1322246006802 motif II; other site 1322246006803 endonuclease IV; Provisional; Region: PRK01060 1322246006804 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 1322246006805 AP (apurinic/apyrimidinic) site pocket; other site 1322246006806 DNA interaction; other site 1322246006807 Metal-binding active site; metal-binding site 1322246006808 peroxiredoxin; Region: AhpC; TIGR03137 1322246006809 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1322246006810 dimer interface [polypeptide binding]; other site 1322246006811 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1322246006812 catalytic triad [active] 1322246006813 peroxidatic and resolving cysteines [active] 1322246006814 Predicted Zn-dependent peptidases, insulinase-like [General function prediction only]; Region: COG1026 1322246006815 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1322246006816 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1322246006817 Peptidase M16C associated; Region: M16C_assoc; pfam08367 1322246006818 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 1322246006819 AMIN domain; Region: AMIN; pfam11741 1322246006820 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1322246006821 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1322246006822 active site 1322246006823 metal binding site [ion binding]; metal-binding site 1322246006824 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1322246006825 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 1322246006826 active site 1322246006827 metal binding site [ion binding]; metal-binding site 1322246006828 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1322246006829 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1322246006830 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1322246006831 Walker A/P-loop; other site 1322246006832 ATP binding site [chemical binding]; other site 1322246006833 Q-loop/lid; other site 1322246006834 ABC transporter signature motif; other site 1322246006835 Walker B; other site 1322246006836 D-loop; other site 1322246006837 H-loop/switch region; other site 1322246006838 CheD chemotactic sensory transduction; Region: CheD; cl00810 1322246006839 HDOD domain; Region: HDOD; pfam08668 1322246006840 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 1322246006841 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 1322246006842 active site 1322246006843 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 1322246006844 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1322246006845 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1322246006846 shikimate binding site; other site 1322246006847 NAD(P) binding site [chemical binding]; other site 1322246006848 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1322246006849 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1322246006850 carbamoyl phosphate synthase-like protein; Provisional; Region: PRK12767 1322246006851 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 1322246006852 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 1322246006853 REG-2-like, HAD superfamily (subfamily IA) hydrolase; Region: DREG-2; TIGR02252 1322246006854 aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181 1322246006855 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1322246006856 inhibitor-cofactor binding pocket; inhibition site 1322246006857 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1322246006858 catalytic residue [active] 1322246006859 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 1322246006860 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 1322246006861 NAD(P) binding site [chemical binding]; other site 1322246006862 homodimer interface [polypeptide binding]; other site 1322246006863 substrate binding site [chemical binding]; other site 1322246006864 active site 1322246006865 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 1322246006866 HIT family signature motif; other site 1322246006867 catalytic residue [active] 1322246006868 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1322246006869 IHF - DNA interface [nucleotide binding]; other site 1322246006870 IHF dimer interface [polypeptide binding]; other site 1322246006871 Sporulation related domain; Region: SPOR; pfam05036 1322246006872 CAAX protease self-immunity; Region: Abi; pfam02517 1322246006873 amphi-Trp domain; Region: amphi-Trp; TIGR04354 1322246006874 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1322246006875 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1322246006876 P-loop; other site 1322246006877 Magnesium ion binding site [ion binding]; other site 1322246006878 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1322246006879 Magnesium ion binding site [ion binding]; other site 1322246006880 amphi-Trp domain; Region: amphi-Trp; TIGR04354 1322246006881 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 1322246006882 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 1322246006883 phosphate binding site [ion binding]; other site 1322246006884 putative substrate binding pocket [chemical binding]; other site 1322246006885 dimer interface [polypeptide binding]; other site 1322246006886 HprK-related kinase B; Region: HprK_rel_B; TIGR04355 1322246006887 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270 1322246006888 active site 1322246006889 metal-binding site [ion binding] 1322246006890 nucleotide-binding site [chemical binding]; other site 1322246006891 ATP-grasp enzyme, GAK system; Region: grasp_GAK; TIGR04356 1322246006892 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1322246006893 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 1322246006894 PhoU domain; Region: PhoU; pfam01895 1322246006895 PhoU domain; Region: PhoU; pfam01895 1322246006896 amphi-Trp domain; Region: amphi-Trp; TIGR04354 1322246006897 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 1322246006898 XXXCH domain; Region: XXXCH_domain; TIGR04358 1322246006899 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 1322246006900 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1322246006901 active site 1322246006902 dimer interface [polypeptide binding]; other site 1322246006903 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1322246006904 Ligand Binding Site [chemical binding]; other site 1322246006905 Molecular Tunnel; other site 1322246006906 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1322246006907 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1322246006908 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1322246006909 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1322246006910 dimerization interface [polypeptide binding]; other site 1322246006911 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1322246006912 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1322246006913 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1322246006914 dimerization interface [polypeptide binding]; other site 1322246006915 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 1322246006916 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1322246006917 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1322246006918 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1322246006919 dimer interface [polypeptide binding]; other site 1322246006920 phosphorylation site [posttranslational modification] 1322246006921 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1322246006922 ATP binding site [chemical binding]; other site 1322246006923 Mg2+ binding site [ion binding]; other site 1322246006924 G-X-G motif; other site 1322246006925 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1322246006926 TPR motif; other site 1322246006927 binding surface 1322246006928 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1322246006929 binding surface 1322246006930 TPR motif; other site 1322246006931 DNA gyrase subunit A; Validated; Region: PRK05560 1322246006932 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1322246006933 CAP-like domain; other site 1322246006934 active site 1322246006935 primary dimer interface [polypeptide binding]; other site 1322246006936 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1322246006937 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1322246006938 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1322246006939 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1322246006940 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1322246006941 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 1322246006942 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1322246006943 ATP binding site [chemical binding]; other site 1322246006944 Mg2+ binding site [ion binding]; other site 1322246006945 G-X-G motif; other site 1322246006946 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1322246006947 anchoring element; other site 1322246006948 dimer interface [polypeptide binding]; other site 1322246006949 ATP binding site [chemical binding]; other site 1322246006950 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1322246006951 active site 1322246006952 putative metal-binding site [ion binding]; other site 1322246006953 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1322246006954 DNA polymerase III subunit beta; Provisional; Region: PRK14947 1322246006955 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1322246006956 putative DNA binding surface [nucleotide binding]; other site 1322246006957 dimer interface [polypeptide binding]; other site 1322246006958 beta-clamp/clamp loader binding surface; other site 1322246006959 beta-clamp/translesion DNA polymerase binding surface; other site 1322246006960 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 1322246006961 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1322246006962 Walker A motif; other site 1322246006963 ATP binding site [chemical binding]; other site 1322246006964 Walker B motif; other site 1322246006965 arginine finger; other site 1322246006966 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1322246006967 DnaA box-binding interface [nucleotide binding]; other site 1322246006968 Domain of unknown function DUF39; Region: DUF39; pfam01837 1322246006969 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; pfam01558 1322246006970 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit [Energy production and conversion]; Region: PorB; COG1013 1322246006971 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 1322246006972 TPP-binding site [chemical binding]; other site 1322246006973 2-ketoisovalerate ferredoxin reductase; Validated; Region: PRK07119 1322246006974 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 1322246006975 dimer interface [polypeptide binding]; other site 1322246006976 PYR/PP interface [polypeptide binding]; other site 1322246006977 TPP binding site [chemical binding]; other site 1322246006978 substrate binding site [chemical binding]; other site 1322246006979 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 1322246006980 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 1322246006981 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 1322246006982 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 1322246006983 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 1322246006984 Flavoprotein; Region: Flavoprotein; pfam02441 1322246006985 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 1322246006986 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 1322246006987 Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_1; cd07020 1322246006988 dimer interface [polypeptide binding]; other site 1322246006989 active site residues [active] 1322246006990 NfeD-like C-terminal, partner-binding; Region: NfeD; pfam01957 1322246006991 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1322246006992 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 1322246006993 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1322246006994 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 1322246006995 putative NAD(P) binding site [chemical binding]; other site 1322246006996 active site 1322246006997 putative substrate binding site [chemical binding]; other site 1322246006998 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1322246006999 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1322246007000 P-loop; other site 1322246007001 Magnesium ion binding site [ion binding]; other site 1322246007002 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1322246007003 Magnesium ion binding site [ion binding]; other site 1322246007004 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1322246007005 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 1322246007006 ParB-like nuclease domain; Region: ParB; smart00470 1322246007007 KorB domain; Region: KorB; pfam08535 1322246007008 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1322246007009 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 1322246007010 putative ribose interaction site [chemical binding]; other site 1322246007011 putative ADP binding site [chemical binding]; other site 1322246007012 diphosphate--fructose-6-phosphate 1-phosphotransferase; Provisional; Region: PRK06830 1322246007013 6-phosphofructokinase; Region: PLN02884 1322246007014 active site 1322246007015 ADP/pyrophosphate binding site [chemical binding]; other site 1322246007016 dimerization interface [polypeptide binding]; other site 1322246007017 allosteric effector site; other site 1322246007018 fructose-1,6-bisphosphate binding site; other site 1322246007019 MarR family; Region: MarR; pfam01047 1322246007020 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 1322246007021 Protein of unknown function (DUF3431); Region: DUF3431; pfam11913 1322246007022 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1322246007023 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1322246007024 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1322246007025 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1322246007026 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1322246007027 active site 1322246007028 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1322246007029 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it thus inhibiting its potentially lethal RNase activity inside the cell; Region: Barstar; cd05142 1322246007030 RNAase interaction site [polypeptide binding]; other site 1322246007031 haemagglutination activity domain; Region: Haemagg_act; pfam05860 1322246007032 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 1322246007033 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 1322246007034 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 1322246007035 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 1322246007036 Possible hemagglutinin (DUF637); Region: DUF637; pfam04830 1322246007037 microbial_RNases. Ribonucleases (RNAses) cleave phosphodiester bonds in RNA and are essential for both non-specific RNA degradation and for numerous forms of RNA processing. The alignment contains fungal RNases (U2, T1, F1, Th, Pb, N1, and Ms) and...; Region: microbial_RNases; cl00212 1322246007038 active site 1322246007039 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 1322246007040 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 1322246007041 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 1322246007042 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 1322246007043 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1322246007044 acyl-activating enzyme (AAE) consensus motif; other site 1322246007045 AMP binding site [chemical binding]; other site 1322246007046 active site 1322246007047 CoA binding site [chemical binding]; other site 1322246007048 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1322246007049 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1322246007050 active site 1322246007051 catalytic residues [active] 1322246007052 DNA binding site [nucleotide binding] 1322246007053 Int/Topo IB signature motif; other site 1322246007054 Helix-turn-helix domain; Region: HTH_17; pfam12728 1322246007055 Transposase IS200 like; Region: Y1_Tnp; pfam01797 1322246007056 Cobalamin biosynthesis protein CobT; Region: CobT; pfam06213 1322246007057 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1322246007058 metal ion-dependent adhesion site (MIDAS); other site 1322246007059 Protein of unknown function (DUF3150); Region: DUF3150; pfam11348 1322246007060 cobaltochelatase, CobS subunit; Region: PD_CobS; TIGR01650 1322246007061 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1322246007062 Walker A motif; other site 1322246007063 ATP binding site [chemical binding]; other site 1322246007064 Walker B motif; other site 1322246007065 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1322246007066 Sel1-like repeats; Region: SEL1; smart00671 1322246007067 HsdM N-terminal domain; Region: HsdM_N; pfam12161 1322246007068 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 1322246007069 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1322246007070 S-adenosylmethionine binding site [chemical binding]; other site 1322246007071 Virulence protein [General function prediction only]; Region: COG3943 1322246007072 Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310 1322246007073 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1322246007074 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 1322246007075 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1322246007076 Abortive infection C-terminus; Region: Abi_C; pfam14355 1322246007077 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 1322246007078 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 1322246007079 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1322246007080 ATP binding site [chemical binding]; other site 1322246007081 putative Mg++ binding site [ion binding]; other site 1322246007082 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 1322246007083 Uncharacterized protein family UPF0102; Region: UPF0102; cl00516 1322246007084 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1322246007085 FeS/SAM binding site; other site 1322246007086 Protein of unknown function (DUF3296); Region: DUF3296; pfam11726 1322246007087 Protein of unknown function (DUF3987); Region: DUF3987; pfam13148 1322246007088 Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310 1322246007089 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1322246007090 RNA helicase (UPF2 interacting domain); Region: UPF1_Zn_bind; pfam09416 1322246007091 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 1322246007092 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1322246007093 dimerization interface [polypeptide binding]; other site 1322246007094 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1322246007095 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1322246007096 dimer interface [polypeptide binding]; other site 1322246007097 putative CheW interface [polypeptide binding]; other site 1322246007098 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 1322246007099 active site clefts [active] 1322246007100 zinc binding site [ion binding]; other site 1322246007101 dimer interface [polypeptide binding]; other site 1322246007102 helicase 45; Provisional; Region: PTZ00424 1322246007103 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1322246007104 ATP binding site [chemical binding]; other site 1322246007105 Mg++ binding site [ion binding]; other site 1322246007106 motif III; other site 1322246007107 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1322246007108 nucleotide binding region [chemical binding]; other site 1322246007109 ATP-binding site [chemical binding]; other site 1322246007110 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 1322246007111 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 1322246007112 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 1322246007113 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08870 1322246007114 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1322246007115 flagellar hook-associated protein FlgK; Region: flgK_ends; TIGR02492 1322246007116 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK08471 1322246007117 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 1322246007118 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1322246007119 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 1322246007120 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1322246007121 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 1322246007122 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 1322246007123 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1322246007124 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1322246007125 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1322246007126 DNA binding residues [nucleotide binding] 1322246007127 flagellin; Provisional; Region: PRK12802 1322246007128 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1322246007129 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1322246007130 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1322246007131 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1322246007132 active site 1322246007133 phosphorylation site [posttranslational modification] 1322246007134 intermolecular recognition site; other site 1322246007135 dimerization interface [polypeptide binding]; other site 1322246007136 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1322246007137 DNA binding site [nucleotide binding] 1322246007138 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1322246007139 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1322246007140 Domain of unknown function (DUF4154); Region: DUF4154; pfam13689 1322246007141 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1322246007142 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1322246007143 dimerization interface [polypeptide binding]; other site 1322246007144 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1322246007145 phosphorylation site [posttranslational modification] 1322246007146 dimer interface [polypeptide binding]; other site 1322246007147 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1322246007148 ATP binding site [chemical binding]; other site 1322246007149 Mg2+ binding site [ion binding]; other site 1322246007150 G-X-G motif; other site 1322246007151 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1322246007152 PAS fold; Region: PAS_3; pfam08447 1322246007153 putative active site [active] 1322246007154 heme pocket [chemical binding]; other site 1322246007155 PAS fold; Region: PAS; pfam00989 1322246007156 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1322246007157 putative active site [active] 1322246007158 heme pocket [chemical binding]; other site 1322246007159 PAS domain S-box; Region: sensory_box; TIGR00229 1322246007160 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1322246007161 putative active site [active] 1322246007162 heme pocket [chemical binding]; other site 1322246007163 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1322246007164 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1322246007165 putative active site [active] 1322246007166 heme pocket [chemical binding]; other site 1322246007167 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1322246007168 dimer interface [polypeptide binding]; other site 1322246007169 phosphorylation site [posttranslational modification] 1322246007170 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1322246007171 ATP binding site [chemical binding]; other site 1322246007172 Mg2+ binding site [ion binding]; other site 1322246007173 G-X-G motif; other site 1322246007174 Response regulator receiver domain; Region: Response_reg; pfam00072 1322246007175 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1322246007176 active site 1322246007177 phosphorylation site [posttranslational modification] 1322246007178 intermolecular recognition site; other site 1322246007179 dimerization interface [polypeptide binding]; other site 1322246007180 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1322246007181 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1322246007182 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1322246007183 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1322246007184 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1322246007185 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1322246007186 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1322246007187 Cytidylate kinase-like family; Region: Cytidylate_kin2; pfam13189 1322246007188 Response regulator receiver domain; Region: Response_reg; pfam00072 1322246007189 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1322246007190 active site 1322246007191 phosphorylation site [posttranslational modification] 1322246007192 intermolecular recognition site; other site 1322246007193 dimerization interface [polypeptide binding]; other site 1322246007194 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1322246007195 dimer interface [polypeptide binding]; other site 1322246007196 phosphorylation site [posttranslational modification] 1322246007197 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1322246007198 ATP binding site [chemical binding]; other site 1322246007199 Mg2+ binding site [ion binding]; other site 1322246007200 G-X-G motif; other site 1322246007201 Response regulator receiver domain; Region: Response_reg; pfam00072 1322246007202 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1322246007203 active site 1322246007204 phosphorylation site [posttranslational modification] 1322246007205 intermolecular recognition site; other site 1322246007206 dimerization interface [polypeptide binding]; other site 1322246007207 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1322246007208 Response regulator receiver domain; Region: Response_reg; pfam00072 1322246007209 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1322246007210 active site 1322246007211 phosphorylation site [posttranslational modification] 1322246007212 intermolecular recognition site; other site 1322246007213 dimerization interface [polypeptide binding]; other site 1322246007214 Sulfotransferase family; Region: Sulfotransfer_2; pfam03567 1322246007215 fumarate hydratase; Reviewed; Region: fumC; PRK00485 1322246007216 Class II fumarases; Region: Fumarase_classII; cd01362 1322246007217 active site 1322246007218 tetramer interface [polypeptide binding]; other site 1322246007219 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1322246007220 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1322246007221 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1322246007222 DNA-binding site [nucleotide binding]; DNA binding site 1322246007223 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1322246007224 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1322246007225 homodimer interface [polypeptide binding]; other site 1322246007226 catalytic residue [active] 1322246007227 Protein of unknown function (DUF2959); Region: DUF2959; pfam11172 1322246007228 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 1322246007229 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1322246007230 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1322246007231 dimerization interface [polypeptide binding]; other site 1322246007232 LysE type translocator; Region: LysE; cl00565 1322246007233 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1322246007234 Zn2+ binding site [ion binding]; other site 1322246007235 Mg2+ binding site [ion binding]; other site 1322246007236 hypothetical protein; Provisional; Region: PRK11568 1322246007237 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 1322246007238 LemA family; Region: LemA; pfam04011 1322246007239 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 1322246007240 Repair protein; Region: Repair_PSII; pfam04536 1322246007241 Repair protein; Region: Repair_PSII; cl01535 1322246007242 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 1322246007243 active site 1322246007244 HDOD domain; Region: HDOD; pfam08668 1322246007245 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1322246007246 Zn2+ binding site [ion binding]; other site 1322246007247 Mg2+ binding site [ion binding]; other site 1322246007248 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 1322246007249 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 1322246007250 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 1322246007251 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1322246007252 nucleotide binding site [chemical binding]; other site 1322246007253 Acetokinase family; Region: Acetate_kinase; cl17229 1322246007254 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 1322246007255 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 1322246007256 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1322246007257 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 1322246007258 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1322246007259 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1322246007260 transmembrane helices; other site 1322246007261 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 1322246007262 Ligand Binding Site [chemical binding]; other site 1322246007263 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1322246007264 Ligand Binding Site [chemical binding]; other site 1322246007265 glutamate racemase; Provisional; Region: PRK00865 1322246007266 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1322246007267 Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434 1322246007268 GAF domain; Region: GAF_2; pfam13185 1322246007269 GAF domain; Region: GAF; pfam01590 1322246007270 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1322246007271 Zn2+ binding site [ion binding]; other site 1322246007272 Mg2+ binding site [ion binding]; other site 1322246007273 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 1322246007274 NADPH bind site [chemical binding]; other site 1322246007275 putative FMN binding site [chemical binding]; other site 1322246007276 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 1322246007277 putative FMN binding site [chemical binding]; other site 1322246007278 NADPH bind site [chemical binding]; other site 1322246007279 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1322246007280 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1322246007281 putative active site [active] 1322246007282 heme pocket [chemical binding]; other site 1322246007283 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1322246007284 dimer interface [polypeptide binding]; other site 1322246007285 phosphorylation site [posttranslational modification] 1322246007286 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1322246007287 ATP binding site [chemical binding]; other site 1322246007288 Mg2+ binding site [ion binding]; other site 1322246007289 G-X-G motif; other site 1322246007290 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH4; cd08188 1322246007291 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 1322246007292 putative active site [active] 1322246007293 metal binding site [ion binding]; metal-binding site 1322246007294 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1322246007295 PAS domain S-box; Region: sensory_box; TIGR00229 1322246007296 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1322246007297 putative active site [active] 1322246007298 heme pocket [chemical binding]; other site 1322246007299 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1322246007300 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1322246007301 putative active site [active] 1322246007302 heme pocket [chemical binding]; other site 1322246007303 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1322246007304 dimer interface [polypeptide binding]; other site 1322246007305 phosphorylation site [posttranslational modification] 1322246007306 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1322246007307 ATP binding site [chemical binding]; other site 1322246007308 Mg2+ binding site [ion binding]; other site 1322246007309 G-X-G motif; other site 1322246007310 Response regulator receiver domain; Region: Response_reg; pfam00072 1322246007311 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1322246007312 active site 1322246007313 phosphorylation site [posttranslational modification] 1322246007314 intermolecular recognition site; other site 1322246007315 dimerization interface [polypeptide binding]; other site 1322246007316 FOG: HPt domain [Signal transduction mechanisms]; Region: ArcB; COG2198 1322246007317 hybrid cluster protein; Provisional; Region: PRK05290 1322246007318 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1322246007319 ACS interaction site; other site 1322246007320 CODH interaction site; other site 1322246007321 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 1322246007322 hybrid metal cluster; other site 1322246007323 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1322246007324 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1322246007325 substrate binding pocket [chemical binding]; other site 1322246007326 membrane-bound complex binding site; other site 1322246007327 hinge residues; other site 1322246007328 Response regulator receiver domain; Region: Response_reg; pfam00072 1322246007329 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1322246007330 active site 1322246007331 phosphorylation site [posttranslational modification] 1322246007332 intermolecular recognition site; other site 1322246007333 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1322246007334 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1322246007335 putative active site [active] 1322246007336 heme pocket [chemical binding]; other site 1322246007337 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1322246007338 putative active site [active] 1322246007339 heme pocket [chemical binding]; other site 1322246007340 PAS domain; Region: PAS_9; pfam13426 1322246007341 PAS domain S-box; Region: sensory_box; TIGR00229 1322246007342 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1322246007343 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1322246007344 putative active site [active] 1322246007345 heme pocket [chemical binding]; other site 1322246007346 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1322246007347 putative active site [active] 1322246007348 heme pocket [chemical binding]; other site 1322246007349 GAF domain; Region: GAF_3; pfam13492 1322246007350 GAF domain; Region: GAF_2; pfam13185 1322246007351 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1322246007352 dimer interface [polypeptide binding]; other site 1322246007353 phosphorylation site [posttranslational modification] 1322246007354 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1322246007355 ATP binding site [chemical binding]; other site 1322246007356 Mg2+ binding site [ion binding]; other site 1322246007357 G-X-G motif; other site 1322246007358 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1322246007359 Response regulator receiver domain; Region: Response_reg; pfam00072 1322246007360 active site 1322246007361 phosphorylation site [posttranslational modification] 1322246007362 intermolecular recognition site; other site 1322246007363 dimerization interface [polypeptide binding]; other site 1322246007364 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 1322246007365 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1322246007366 Zn2+ binding site [ion binding]; other site 1322246007367 Mg2+ binding site [ion binding]; other site 1322246007368 glycine betaine transporter periplasmic subunit; Provisional; Region: proX; PRK11119 1322246007369 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1322246007370 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1322246007371 dimer interface [polypeptide binding]; other site 1322246007372 conserved gate region; other site 1322246007373 putative PBP binding loops; other site 1322246007374 ABC-ATPase subunit interface; other site 1322246007375 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 1322246007376 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 1322246007377 Walker A/P-loop; other site 1322246007378 ATP binding site [chemical binding]; other site 1322246007379 Q-loop/lid; other site 1322246007380 ABC transporter signature motif; other site 1322246007381 Walker B; other site 1322246007382 D-loop; other site 1322246007383 H-loop/switch region; other site 1322246007384 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 1322246007385 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1322246007386 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1322246007387 metal binding site [ion binding]; metal-binding site 1322246007388 active site 1322246007389 I-site; other site 1322246007390 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1322246007391 Zn2+ binding site [ion binding]; other site 1322246007392 Mg2+ binding site [ion binding]; other site 1322246007393 Protein of unknown function (DUF429); Region: DUF429; cl12046 1322246007394 Protein of unknown function, DUF399; Region: DUF399; pfam04187 1322246007395 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1322246007396 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 1322246007397 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 1322246007398 DNA binding site [nucleotide binding] 1322246007399 catalytic residue [active] 1322246007400 H2TH interface [polypeptide binding]; other site 1322246007401 putative catalytic residues [active] 1322246007402 turnover-facilitating residue; other site 1322246007403 intercalation triad [nucleotide binding]; other site 1322246007404 8OG recognition residue [nucleotide binding]; other site 1322246007405 putative reading head residues; other site 1322246007406 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1322246007407 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1322246007408 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 1322246007409 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 1322246007410 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 1322246007411 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1322246007412 Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; pfam09719 1322246007413 Protein of unknown function (DUF3795); Region: DUF3795; pfam12675 1322246007414 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1322246007415 AAA domain; Region: AAA_23; pfam13476 1322246007416 Walker A/P-loop; other site 1322246007417 ATP binding site [chemical binding]; other site 1322246007418 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1322246007419 active site 1322246007420 metal binding site [ion binding]; metal-binding site 1322246007421 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1322246007422 Septum formation initiator; Region: DivIC; cl17659 1322246007423 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1322246007424 Walker B; other site 1322246007425 D-loop; other site 1322246007426 H-loop/switch region; other site 1322246007427 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1322246007428 catalytic residues [active] 1322246007429 Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018 1322246007430 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1322246007431 dimer interface [polypeptide binding]; other site 1322246007432 catalytic triad [active] 1322246007433 Response regulator receiver domain; Region: Response_reg; pfam00072 1322246007434 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1322246007435 active site 1322246007436 phosphorylation site [posttranslational modification] 1322246007437 intermolecular recognition site; other site 1322246007438 dimerization interface [polypeptide binding]; other site 1322246007439 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1322246007440 anti sigma factor interaction site; other site 1322246007441 regulatory phosphorylation site [posttranslational modification]; other site 1322246007442 HAMP domain; Region: HAMP; pfam00672 1322246007443 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1322246007444 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1322246007445 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1322246007446 putative active site [active] 1322246007447 heme pocket [chemical binding]; other site 1322246007448 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1322246007449 dimer interface [polypeptide binding]; other site 1322246007450 phosphorylation site [posttranslational modification] 1322246007451 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1322246007452 ATP binding site [chemical binding]; other site 1322246007453 Mg2+ binding site [ion binding]; other site 1322246007454 G-X-G motif; other site 1322246007455 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1322246007456 Type I periplasmic binding domain of uncharacterized extracellular ligand-binding proteins; Region: PBP1_STKc_like; cd06326 1322246007457 putative ligand binding site [chemical binding]; other site 1322246007458 FOG: CBS domain [General function prediction only]; Region: COG0517 1322246007459 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc2; cd04585 1322246007460 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1322246007461 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1322246007462 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1322246007463 Metal-binding active site; metal-binding site 1322246007464 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1322246007465 CoenzymeA binding site [chemical binding]; other site 1322246007466 subunit interaction site [polypeptide binding]; other site 1322246007467 PHB binding site; other site 1322246007468 thioredoxin 2; Provisional; Region: PRK10996 1322246007469 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1322246007470 catalytic residues [active] 1322246007471 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 1322246007472 membrane-bound complex binding site; other site 1322246007473 hinge residues; other site 1322246007474 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 1322246007475 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1322246007476 Radical SAM superfamily; Region: Radical_SAM; pfam04055 1322246007477 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1322246007478 FeS/SAM binding site; other site 1322246007479 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 1322246007480 dimerization interface [polypeptide binding]; other site 1322246007481 putative DNA binding site [nucleotide binding]; other site 1322246007482 putative Zn2+ binding site [ion binding]; other site 1322246007483 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 1322246007484 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1322246007485 homodimer interface [polypeptide binding]; other site 1322246007486 oligonucleotide binding site [chemical binding]; other site 1322246007487 NusB family; Region: NusB; pfam01029 1322246007488 putative RNA binding site [nucleotide binding]; other site 1322246007489 16S rRNA methyltransferase B; Provisional; Region: PRK14902 1322246007490 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1322246007491 S-adenosylmethionine binding site [chemical binding]; other site 1322246007492 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 1322246007493 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1322246007494 ATP binding site [chemical binding]; other site 1322246007495 putative Mg++ binding site [ion binding]; other site 1322246007496 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1322246007497 nucleotide binding region [chemical binding]; other site 1322246007498 ATP-binding site [chemical binding]; other site 1322246007499 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 1322246007500 HRDC domain; Region: HRDC; pfam00570 1322246007501 PAS fold; Region: PAS_3; pfam08447 1322246007502 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1322246007503 PAS fold; Region: PAS_3; pfam08447 1322246007504 putative active site [active] 1322246007505 heme pocket [chemical binding]; other site 1322246007506 PAS fold; Region: PAS_4; pfam08448 1322246007507 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1322246007508 putative active site [active] 1322246007509 heme pocket [chemical binding]; other site 1322246007510 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1322246007511 PAS domain; Region: PAS_9; pfam13426 1322246007512 putative active site [active] 1322246007513 heme pocket [chemical binding]; other site 1322246007514 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1322246007515 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1322246007516 dimer interface [polypeptide binding]; other site 1322246007517 phosphorylation site [posttranslational modification] 1322246007518 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1322246007519 ATP binding site [chemical binding]; other site 1322246007520 Mg2+ binding site [ion binding]; other site 1322246007521 G-X-G motif; other site 1322246007522 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290 1322246007523 Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434 1322246007524 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 1322246007525 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 1322246007526 putative active site; other site 1322246007527 catalytic residue [active] 1322246007528 HEAT repeats; Region: HEAT_2; pfam13646 1322246007529 HEAT repeats; Region: HEAT_2; pfam13646 1322246007530 Helix-turn-helix domain; Region: HTH_19; pfam12844 1322246007531 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462 1322246007532 Catalytic site [active] 1322246007533 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 1322246007534 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1322246007535 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1322246007536 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 1322246007537 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 1322246007538 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1322246007539 dimerization interface [polypeptide binding]; other site 1322246007540 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1322246007541 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1322246007542 dimer interface [polypeptide binding]; other site 1322246007543 putative CheW interface [polypeptide binding]; other site 1322246007544 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1322246007545 Zn2+ binding site [ion binding]; other site 1322246007546 Mg2+ binding site [ion binding]; other site 1322246007547 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 1322246007548 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1322246007549 Zn2+ binding site [ion binding]; other site 1322246007550 Mg2+ binding site [ion binding]; other site 1322246007551 hypothetical protein; Region: PHA00662 1322246007552 Staphylococcal nuclease homologues; Region: SNc; smart00318 1322246007553 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 1322246007554 Catalytic site; other site 1322246007555 Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237 1322246007556 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 1322246007557 active site 1322246007558 homotetramer interface [polypeptide binding]; other site 1322246007559 homodimer interface [polypeptide binding]; other site 1322246007560 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1322246007561 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1322246007562 [Protein-PII] uridylyltransferase; Region: UTase_glnD; TIGR01693 1322246007563 metal binding triad; other site 1322246007564 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1322246007565 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1322246007566 Zn2+ binding site [ion binding]; other site 1322246007567 Mg2+ binding site [ion binding]; other site 1322246007568 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 1322246007569 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 1322246007570 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 1322246007571 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1322246007572 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 1322246007573 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1322246007574 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1322246007575 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 1322246007576 CoA binding domain; Region: CoA_binding_2; pfam13380 1322246007577 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 1322246007578 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 1322246007579 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1322246007580 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1322246007581 acetyl-CoA synthetase; Provisional; Region: PRK00174 1322246007582 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 1322246007583 active site 1322246007584 CoA binding site [chemical binding]; other site 1322246007585 acyl-activating enzyme (AAE) consensus motif; other site 1322246007586 AMP binding site [chemical binding]; other site 1322246007587 acetate binding site [chemical binding]; other site 1322246007588 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 1322246007589 active site 2 [active] 1322246007590 active site 1 [active] 1322246007591 Protein kinase domain; Region: Pkinase; pfam00069 1322246007592 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1322246007593 active site 1322246007594 ATP binding site [chemical binding]; other site 1322246007595 substrate binding site [chemical binding]; other site 1322246007596 activation loop (A-loop); other site 1322246007597 Protein of unknown function (DUF1566); Region: DUF1566; pfam07603 1322246007598 zinc transporter ZupT; Provisional; Region: PRK04201 1322246007599 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14460 1322246007600 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 1322246007601 FeS/SAM binding site; other site 1322246007602 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 1322246007603 Na2 binding site [ion binding]; other site 1322246007604 putative substrate binding site 1 [chemical binding]; other site 1322246007605 Na binding site 1 [ion binding]; other site 1322246007606 putative substrate binding site 2 [chemical binding]; other site 1322246007607 putative protease; Region: PHA00666 1322246007608 hypothetical protein; Region: PHA00670 1322246007609 Bacteriophage head to tail connecting protein; Region: Head-tail_con; pfam12236 1322246007610 C2 domain; Region: C2; cl14603 1322246007611 Terminase-like family; Region: Terminase_6; pfam03237 1322246007612 large terminase protein; Provisional; Region: 17; PHA02533 1322246007613 TPR repeat; Region: TPR_11; pfam13414 1322246007614 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1322246007615 binding surface 1322246007616 TPR repeat; Region: TPR_11; pfam13414 1322246007617 TPR motif; other site 1322246007618 TPR repeat; Region: TPR_11; pfam13414 1322246007619 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1322246007620 binding surface 1322246007621 TPR motif; other site 1322246007622 TPR repeat; Region: TPR_11; pfam13414 1322246007623 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 1322246007624 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1322246007625 FMN binding site [chemical binding]; other site 1322246007626 active site 1322246007627 catalytic residues [active] 1322246007628 substrate binding site [chemical binding]; other site 1322246007629 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 1322246007630 EamA-like transporter family; Region: EamA; pfam00892 1322246007631 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1322246007632 EamA-like transporter family; Region: EamA; pfam00892 1322246007633 SlyX; Region: SlyX; pfam04102 1322246007634 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 1322246007635 SPRY domain; Region: SPRY; cl02614 1322246007636 Phage T7 tail fibre protein; Region: Phage_T7_tail; pfam03906 1322246007637 hypothetical protein; Region: PHA00661 1322246007638 hypothetical protein; Region: PHA00661 1322246007639 hypothetical protein; Region: PHA00661 1322246007640 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1322246007641 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 1322246007642 putative substrate binding site [chemical binding]; other site 1322246007643 putative ATP binding site [chemical binding]; other site 1322246007644 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1322246007645 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1322246007646 binding surface 1322246007647 TPR motif; other site 1322246007648 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1322246007649 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1322246007650 Tetratricopeptide repeat; Region: TPR_10; pfam13374 1322246007651 Tetratricopeptide repeat; Region: TPR_10; pfam13374 1322246007652 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 1322246007653 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1322246007654 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 1322246007655 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1322246007656 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 1322246007657 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1322246007658 putative binding surface; other site 1322246007659 active site 1322246007660 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1322246007661 This family is most closely related to the GT1 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis; Region: GT1_WbnK_like; cd03807 1322246007662 putative ADP-binding pocket [chemical binding]; other site 1322246007663 Protein of unknown function (DUF1007); Region: DUF1007; cl01487 1322246007664 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG2215 1322246007665 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1322246007666 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1322246007667 substrate binding pocket [chemical binding]; other site 1322246007668 membrane-bound complex binding site; other site 1322246007669 hinge residues; other site 1322246007670 HAMP domain; Region: HAMP; pfam00672 1322246007671 dimerization interface [polypeptide binding]; other site 1322246007672 PAS fold; Region: PAS; pfam00989 1322246007673 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1322246007674 putative active site [active] 1322246007675 heme pocket [chemical binding]; other site 1322246007676 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1322246007677 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1322246007678 dimer interface [polypeptide binding]; other site 1322246007679 phosphorylation site [posttranslational modification] 1322246007680 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1322246007681 ATP binding site [chemical binding]; other site 1322246007682 Mg2+ binding site [ion binding]; other site 1322246007683 G-X-G motif; other site 1322246007684 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 1322246007685 PAS domain S-box; Region: sensory_box; TIGR00229 1322246007686 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1322246007687 putative active site [active] 1322246007688 heme pocket [chemical binding]; other site 1322246007689 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1322246007690 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1322246007691 metal binding site [ion binding]; metal-binding site 1322246007692 active site 1322246007693 I-site; other site 1322246007694 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1322246007695 PAS domain S-box; Region: sensory_box; TIGR00229 1322246007696 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1322246007697 putative active site [active] 1322246007698 heme pocket [chemical binding]; other site 1322246007699 PAS domain; Region: PAS_9; pfam13426 1322246007700 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1322246007701 putative active site [active] 1322246007702 heme pocket [chemical binding]; other site 1322246007703 PAS domain S-box; Region: sensory_box; TIGR00229 1322246007704 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1322246007705 putative active site [active] 1322246007706 heme pocket [chemical binding]; other site 1322246007707 PAS domain S-box; Region: sensory_box; TIGR00229 1322246007708 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1322246007709 putative active site [active] 1322246007710 heme pocket [chemical binding]; other site 1322246007711 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1322246007712 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1322246007713 metal binding site [ion binding]; metal-binding site 1322246007714 active site 1322246007715 I-site; other site 1322246007716 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1322246007717 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1322246007718 metal binding site [ion binding]; metal-binding site 1322246007719 active site 1322246007720 I-site; other site 1322246007721 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1322246007722 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 1322246007723 Nitroreductase family. Members of this family utilize FMN as a cofactor. This family is involved in the reduction of flavin or nitroaromatic compounds by using NAD(P)H as electron donor in a obligatory two-electron transfer. Nitrogenase is homodimer; Region: NADH_nitroreductase; cd02143 1322246007724 putative FMN binding site [chemical binding]; other site 1322246007725 3D domain; Region: 3D; cl01439 1322246007726 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 1322246007727 PilZ domain; Region: PilZ; pfam07238 1322246007728 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 1322246007729 PIN domain; Region: PIN_Smg5-Smg6-like; cd09880 1322246007730 putative active site [active] 1322246007731 PhoH-like protein; Region: PhoH; pfam02562 1322246007732 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1322246007733 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1322246007734 catalytic residue [active] 1322246007735 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1322246007736 malate synthase G; Provisional; Region: PRK02999 1322246007737 active site 1322246007738 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1322246007739 dimerization interface [polypeptide binding]; other site 1322246007740 putative DNA binding site [nucleotide binding]; other site 1322246007741 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 1322246007742 putative Zn2+ binding site [ion binding]; other site 1322246007743 AsnC family; Region: AsnC_trans_reg; pfam01037 1322246007744 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 1322246007745 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 1322246007746 hexamer interface [polypeptide binding]; other site 1322246007747 ligand binding site [chemical binding]; other site 1322246007748 putative active site [active] 1322246007749 NAD(P) binding site [chemical binding]; other site 1322246007750 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1322246007751 active site residue [active] 1322246007752 Methylamine utilisation protein MauE; Region: MauE; pfam07291 1322246007753 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1322246007754 Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056 1322246007755 heat shock protein 90; Provisional; Region: PRK05218 1322246007756 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1322246007757 ATP binding site [chemical binding]; other site 1322246007758 Mg2+ binding site [ion binding]; other site 1322246007759 G-X-G motif; other site 1322246007760 Chromate transporter; Region: Chromate_transp; pfam02417 1322246007761 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 1322246007762 Chromate transporter; Region: Chromate_transp; pfam02417 1322246007763 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1322246007764 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1322246007765 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1322246007766 ATP binding site [chemical binding]; other site 1322246007767 Mg2+ binding site [ion binding]; other site 1322246007768 G-X-G motif; other site 1322246007769 photolyase PhrII; Region: phr2; TIGR00591 1322246007770 DNA photolyase; Region: DNA_photolyase; pfam00875 1322246007771 Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716 1322246007772 CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870 1322246007773 ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871 1322246007774 phosphoserine phosphatase SerB; Region: serB; TIGR00338 1322246007775 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1322246007776 motif II; other site 1322246007777 Protein of unknown function (DUF1498); Region: DUF1498; cl17840 1322246007778 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 1322246007779 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 1322246007780 RNA/DNA hybrid binding site [nucleotide binding]; other site 1322246007781 active site 1322246007782 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1322246007783 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1322246007784 FtsX-like permease family; Region: FtsX; pfam02687 1322246007785 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1322246007786 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1322246007787 Walker A/P-loop; other site 1322246007788 ATP binding site [chemical binding]; other site 1322246007789 Q-loop/lid; other site 1322246007790 ABC transporter signature motif; other site 1322246007791 Walker B; other site 1322246007792 D-loop; other site 1322246007793 H-loop/switch region; other site 1322246007794 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1322246007795 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1322246007796 HlyD family secretion protein; Region: HlyD_3; pfam13437 1322246007797 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 1322246007798 phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990 1322246007799 active site 1322246007800 substrate binding site [chemical binding]; other site 1322246007801 metal binding site [ion binding]; metal-binding site 1322246007802 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 1322246007803 HflK protein; Region: hflK; TIGR01933 1322246007804 HflC protein; Region: hflC; TIGR01932 1322246007805 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 1322246007806 Bacteriophage CI repressor helix-turn-helix domain; Region: Phage_CI_repr; pfam07022 1322246007807 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462 1322246007808 Catalytic site [active] 1322246007809 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1322246007810 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1322246007811 active site 1322246007812 phosphorylation site [posttranslational modification] 1322246007813 intermolecular recognition site; other site 1322246007814 dimerization interface [polypeptide binding]; other site 1322246007815 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1322246007816 Response regulator receiver domain; Region: Response_reg; pfam00072 1322246007817 active site 1322246007818 phosphorylation site [posttranslational modification] 1322246007819 intermolecular recognition site; other site 1322246007820 dimerization interface [polypeptide binding]; other site 1322246007821 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1322246007822 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1322246007823 metal binding site [ion binding]; metal-binding site 1322246007824 active site 1322246007825 I-site; other site 1322246007826 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 1322246007827 active site 1322246007828 oligomerization interface [polypeptide binding]; other site 1322246007829 metal binding site [ion binding]; metal-binding site 1322246007830 Uncharacterized protein conserved in archaea [Function unknown]; Region: COG3366 1322246007831 GAF domain; Region: GAF; cl17456 1322246007832 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1322246007833 Histidine kinase; Region: HisKA_3; pfam07730 1322246007834 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1322246007835 ATP binding site [chemical binding]; other site 1322246007836 Mg2+ binding site [ion binding]; other site 1322246007837 G-X-G motif; other site 1322246007838 coproporphyrinogen III oxidase; Provisional; Region: PRK05799 1322246007839 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1322246007840 FeS/SAM binding site; other site 1322246007841 HemN C-terminal domain; Region: HemN_C; pfam06969 1322246007842 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases and ATP sulphurylases. The domain forms a apha/beta/apha fold which binds to Adenosine group; Region: Alpha_ANH_like; cd01986 1322246007843 Ligand Binding Site [chemical binding]; other site 1322246007844 Protein involved in formate dehydrogenase formation; Region: FdhE; pfam04216 1322246007845 formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562 1322246007846 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 1322246007847 Transcription factor S-II (TFIIS); Region: TFIIS_C; cl02609 1322246007848 Protein of unknown function (DUF2089); Region: DUF2089; pfam09862 1322246007849 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 1322246007850 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1322246007851 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1322246007852 dimer interface [polypeptide binding]; other site 1322246007853 putative functional site; other site 1322246007854 putative MPT binding site; other site 1322246007855 FdhD/NarQ family; Region: FdhD-NarQ; pfam02634 1322246007856 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 1322246007857 Walker A motif; other site 1322246007858 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1322246007859 Peptidase family U32; Region: Peptidase_U32; pfam01136 1322246007860 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 1322246007861 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 1322246007862 GTP binding site; other site 1322246007863 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1322246007864 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1322246007865 Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845 1322246007866 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 1322246007867 HlyD family secretion protein; Region: HlyD_3; pfam13437 1322246007868 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1322246007869 Protein export membrane protein; Region: SecD_SecF; cl14618 1322246007870 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 1322246007871 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 1322246007872 active site 1322246007873 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 1322246007874 Trm112p-like protein; Region: Trm112p; cl01066 1322246007875 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1322246007876 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1322246007877 putative dimer interface [polypeptide binding]; other site 1322246007878 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1322246007879 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1322246007880 putative dimer interface [polypeptide binding]; other site 1322246007881 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 1322246007882 HAMP domain; Region: HAMP; pfam00672 1322246007883 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1322246007884 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1322246007885 dimer interface [polypeptide binding]; other site 1322246007886 putative CheW interface [polypeptide binding]; other site 1322246007887 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1322246007888 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1322246007889 active site 1322246007890 phosphorylation site [posttranslational modification] 1322246007891 intermolecular recognition site; other site 1322246007892 dimerization interface [polypeptide binding]; other site 1322246007893 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1322246007894 DNA binding residues [nucleotide binding] 1322246007895 dimerization interface [polypeptide binding]; other site 1322246007896 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1322246007897 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1322246007898 putative active site [active] 1322246007899 heme pocket [chemical binding]; other site 1322246007900 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1322246007901 putative active site [active] 1322246007902 heme pocket [chemical binding]; other site 1322246007903 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1322246007904 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1322246007905 putative active site [active] 1322246007906 heme pocket [chemical binding]; other site 1322246007907 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1322246007908 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1322246007909 putative active site [active] 1322246007910 heme pocket [chemical binding]; other site 1322246007911 PAS domain S-box; Region: sensory_box; TIGR00229 1322246007912 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1322246007913 putative active site [active] 1322246007914 heme pocket [chemical binding]; other site 1322246007915 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1322246007916 Histidine kinase; Region: HisKA_3; pfam07730 1322246007917 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1322246007918 ATP binding site [chemical binding]; other site 1322246007919 Mg2+ binding site [ion binding]; other site 1322246007920 G-X-G motif; other site 1322246007921 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1322246007922 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1322246007923 PAS fold; Region: PAS_3; pfam08447 1322246007924 putative active site [active] 1322246007925 heme pocket [chemical binding]; other site 1322246007926 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1322246007927 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1322246007928 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1322246007929 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1322246007930 dimer interface [polypeptide binding]; other site 1322246007931 phosphorylation site [posttranslational modification] 1322246007932 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1322246007933 ATP binding site [chemical binding]; other site 1322246007934 Mg2+ binding site [ion binding]; other site 1322246007935 G-X-G motif; other site 1322246007936 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1322246007937 active site 1322246007938 phosphorylation site [posttranslational modification] 1322246007939 intermolecular recognition site; other site 1322246007940 dimerization interface [polypeptide binding]; other site 1322246007941 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 1322246007942 FOG: CBS domain [General function prediction only]; Region: COG0517 1322246007943 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1322246007944 Response regulator receiver domain; Region: Response_reg; pfam00072 1322246007945 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1322246007946 active site 1322246007947 phosphorylation site [posttranslational modification] 1322246007948 intermolecular recognition site; other site 1322246007949 dimerization interface [polypeptide binding]; other site 1322246007950 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1322246007951 putative active site [active] 1322246007952 heme pocket [chemical binding]; other site 1322246007953 PAS domain; Region: PAS_9; pfam13426 1322246007954 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1322246007955 dimer interface [polypeptide binding]; other site 1322246007956 phosphorylation site [posttranslational modification] 1322246007957 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1322246007958 ATP binding site [chemical binding]; other site 1322246007959 Mg2+ binding site [ion binding]; other site 1322246007960 G-X-G motif; other site 1322246007961 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1322246007962 active site 1322246007963 phosphorylation site [posttranslational modification] 1322246007964 intermolecular recognition site; other site 1322246007965 dimerization interface [polypeptide binding]; other site 1322246007966 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1322246007967 putative binding surface; other site 1322246007968 active site 1322246007969 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 1322246007970 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 1322246007971 HAMP domain; Region: HAMP; pfam00672 1322246007972 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1322246007973 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1322246007974 dimer interface [polypeptide binding]; other site 1322246007975 putative CheW interface [polypeptide binding]; other site 1322246007976 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 1322246007977 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1322246007978 FeS/SAM binding site; other site 1322246007979 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 1322246007980 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1322246007981 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1322246007982 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 1322246007983 molybdopterin cofactor binding site; other site 1322246007984 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1322246007985 Formylmethanofuran dehydrogenase subunit E [Energy production and conversion]; Region: COG2191 1322246007986 FmdE, Molybdenum formylmethanofuran dehydrogenase operon; Region: FmdE; pfam02663 1322246007987 MoeA_like. This domain is similar to a domain found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. There this domain is presumed to bind molybdopterin. The exact function of this subgroup is...; Region: MoeA_like; cd03522 1322246007988 putative MPT binding site; other site 1322246007989 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 1322246007990 conserved cys residue [active] 1322246007991 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1322246007992 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 1322246007993 conserved cys residue [active] 1322246007994 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1322246007995 Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901 1322246007996 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 1322246007997 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 1322246007998 4Fe-4S binding domain; Region: Fer4; cl02805 1322246007999 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1322246008000 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959 1322246008001 RsbT co-antagonist protein rsbRD N-terminal domain; Region: RsbRD_N; pfam14361 1322246008002 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1322246008003 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1322246008004 putative active site [active] 1322246008005 heme pocket [chemical binding]; other site 1322246008006 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1322246008007 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1322246008008 putative active site [active] 1322246008009 heme pocket [chemical binding]; other site 1322246008010 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1322246008011 putative active site [active] 1322246008012 heme pocket [chemical binding]; other site 1322246008013 PAS domain S-box; Region: sensory_box; TIGR00229 1322246008014 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1322246008015 putative active site [active] 1322246008016 heme pocket [chemical binding]; other site 1322246008017 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1322246008018 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1322246008019 metal binding site [ion binding]; metal-binding site 1322246008020 active site 1322246008021 I-site; other site 1322246008022 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1322246008023 EamA-like transporter family; Region: EamA; pfam00892 1322246008024 EamA-like transporter family; Region: EamA; pfam00892 1322246008025 PilZ domain; Region: PilZ; pfam07238 1322246008026 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 1322246008027 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 1322246008028 putative active site [active] 1322246008029 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 1322246008030 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1322246008031 TPP-binding site [chemical binding]; other site 1322246008032 dimer interface [polypeptide binding]; other site 1322246008033 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1322246008034 PYR/PP interface [polypeptide binding]; other site 1322246008035 dimer interface [polypeptide binding]; other site 1322246008036 TPP binding site [chemical binding]; other site 1322246008037 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1322246008038 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 1322246008039 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1322246008040 TPR motif; other site 1322246008041 binding surface 1322246008042 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1322246008043 binding surface 1322246008044 TPR motif; other site 1322246008045 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1322246008046 binding surface 1322246008047 TPR motif; other site 1322246008048 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1322246008049 alternative sigma factor RpoH; Region: rpoH_proteo; TIGR02392 1322246008050 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1322246008051 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1322246008052 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1322246008053 DNA binding residues [nucleotide binding] 1322246008054 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 1322246008055 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 1322246008056 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 1322246008057 substrate binding pocket [chemical binding]; other site 1322246008058 dimer interface [polypeptide binding]; other site 1322246008059 inhibitor binding site; inhibition site 1322246008060 methyltransferase cognate corrinoid proteins, Methanosarcina family; Region: pyl_corrinoid; TIGR02370 1322246008061 B12 binding domain of corrinoid proteins. A family of small methanogenic corrinoid proteins that bind methyl-Co(III) 5-hydroxybenzimidazolylcobamide as a cofactor. They play a role on the methanogenesis from trimethylamine, dimethylamine or...; Region: corrinoid_protein_B12-BD; cd02070 1322246008062 B12 binding site [chemical binding]; other site 1322246008063 cobalt ligand [ion binding]; other site 1322246008064 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 1322246008065 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1322246008066 DNA binding site [nucleotide binding] 1322246008067 active site 1322246008068 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 1322246008069 rod shape-determining protein MreB; Provisional; Region: PRK13927 1322246008070 MreB and similar proteins; Region: MreB_like; cd10225 1322246008071 nucleotide binding site [chemical binding]; other site 1322246008072 Mg binding site [ion binding]; other site 1322246008073 putative protofilament interaction site [polypeptide binding]; other site 1322246008074 RodZ interaction site [polypeptide binding]; other site 1322246008075 rod shape-determining protein MreC; Provisional; Region: PRK13922 1322246008076 rod shape-determining protein MreC; Region: MreC; pfam04085 1322246008077 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 1322246008078 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1322246008079 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1322246008080 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 1322246008081 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 1322246008082 F0F1 ATP synthase subunit B'; Validated; Region: PRK07353 1322246008083 ATP synthase B/B' CF(0); Region: ATP-synt_B; pfam00430 1322246008084 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 1322246008085 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 1322246008086 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13429 1322246008087 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 1322246008088 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1322246008089 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1322246008090 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 1322246008091 beta subunit interaction interface [polypeptide binding]; other site 1322246008092 Walker A motif; other site 1322246008093 ATP binding site [chemical binding]; other site 1322246008094 Walker B motif; other site 1322246008095 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1322246008096 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1322246008097 core domain interface [polypeptide binding]; other site 1322246008098 delta subunit interface [polypeptide binding]; other site 1322246008099 epsilon subunit interface [polypeptide binding]; other site 1322246008100 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1322246008101 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1322246008102 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1322246008103 alpha subunit interaction interface [polypeptide binding]; other site 1322246008104 Walker A motif; other site 1322246008105 ATP binding site [chemical binding]; other site 1322246008106 Walker B motif; other site 1322246008107 inhibitor binding site; inhibition site 1322246008108 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1322246008109 F0F1 ATP synthase subunit epsilon; Provisional; Region: atpC; PRK13446 1322246008110 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1322246008111 gamma subunit interface [polypeptide binding]; other site 1322246008112 epsilon subunit interface [polypeptide binding]; other site 1322246008113 LBP interface [polypeptide binding]; other site 1322246008114 aspartate aminotransferase; Provisional; Region: PRK05764 1322246008115 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1322246008116 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1322246008117 homodimer interface [polypeptide binding]; other site 1322246008118 catalytic residue [active] 1322246008119 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1322246008120 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1322246008121 substrate binding pocket [chemical binding]; other site 1322246008122 membrane-bound complex binding site; other site 1322246008123 hinge residues; other site 1322246008124 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1322246008125 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1322246008126 putative active site [active] 1322246008127 heme pocket [chemical binding]; other site 1322246008128 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1322246008129 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1322246008130 putative active site [active] 1322246008131 heme pocket [chemical binding]; other site 1322246008132 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1322246008133 dimer interface [polypeptide binding]; other site 1322246008134 phosphorylation site [posttranslational modification] 1322246008135 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1322246008136 ATP binding site [chemical binding]; other site 1322246008137 Mg2+ binding site [ion binding]; other site 1322246008138 G-X-G motif; other site 1322246008139 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08665 1322246008140 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 1322246008141 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 1322246008142 active site 1322246008143 dimer interface [polypeptide binding]; other site 1322246008144 effector binding site; other site 1322246008145 TSCPD domain; Region: TSCPD; pfam12637 1322246008146 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1322246008147 binding surface 1322246008148 TPR repeat; Region: TPR_11; pfam13414 1322246008149 TPR motif; other site 1322246008150 TPR repeat; Region: TPR_11; pfam13414 1322246008151 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1322246008152 binding surface 1322246008153 TPR motif; other site 1322246008154 TPR repeat; Region: TPR_11; pfam13414 1322246008155 Protein of unknown function DUF45; Region: DUF45; pfam01863 1322246008156 Uncharacterized conserved protein [Function unknown]; Region: COG1683 1322246008157 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1322246008158 putative substrate translocation pore; other site 1322246008159 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1322246008160 CheD chemotactic sensory transduction; Region: CheD; cl00810 1322246008161 Hpt domain; Region: Hpt; pfam01627 1322246008162 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1322246008163 AMIN domain; Region: AMIN; pfam11741 1322246008164 phosphate transporter ATP-binding protein; Provisional; Region: PRK14242 1322246008165 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1322246008166 Walker A/P-loop; other site 1322246008167 ATP binding site [chemical binding]; other site 1322246008168 Q-loop/lid; other site 1322246008169 ABC transporter signature motif; other site 1322246008170 Walker B; other site 1322246008171 D-loop; other site 1322246008172 H-loop/switch region; other site 1322246008173 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 1322246008174 PhoU domain; Region: PhoU; pfam01895 1322246008175 PhoU domain; Region: PhoU; pfam01895 1322246008176 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 1322246008177 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1322246008178 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1322246008179 dimer interface [polypeptide binding]; other site 1322246008180 phosphorylation site [posttranslational modification] 1322246008181 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1322246008182 ATP binding site [chemical binding]; other site 1322246008183 Mg2+ binding site [ion binding]; other site 1322246008184 G-X-G motif; other site 1322246008185 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1322246008186 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1322246008187 active site 1322246008188 phosphorylation site [posttranslational modification] 1322246008189 intermolecular recognition site; other site 1322246008190 dimerization interface [polypeptide binding]; other site 1322246008191 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 1322246008192 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 1322246008193 RNA binding site [nucleotide binding]; other site 1322246008194 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1322246008195 RNA binding site [nucleotide binding]; other site 1322246008196 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 1322246008197 RNA binding site [nucleotide binding]; other site 1322246008198 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1322246008199 RNA binding site [nucleotide binding]; other site 1322246008200 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 1322246008201 RNA binding site [nucleotide binding]; other site 1322246008202 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 1322246008203 RNA binding site [nucleotide binding]; other site 1322246008204 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 1322246008205 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 1322246008206 tandem repeat interface [polypeptide binding]; other site 1322246008207 oligomer interface [polypeptide binding]; other site 1322246008208 active site residues [active] 1322246008209 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 1322246008210 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 1322246008211 catalytic triad [active] 1322246008212 transport-energizing ATPase, TRC40/GET3/ArsA family; Region: GET3_arsA_TRC40; TIGR00345 1322246008213 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1322246008214 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1322246008215 catalytic residues [active] 1322246008216 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1322246008217 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1322246008218 Coenzyme A binding pocket [chemical binding]; other site 1322246008219 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1322246008220 active site 1322246008221 zinc-ribbon domain; Region: zinc_ribbon_5; pfam13719 1322246008222 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527 1322246008223 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 1322246008224 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 1322246008225 ATP synthase subunit C; Region: ATP-synt_C; cl00466 1322246008226 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 1322246008227 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 1322246008228 CoA binding domain; Region: CoA_binding; pfam02629 1322246008229 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1322246008230 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1322246008231 active site 1322246008232 phosphorylation site [posttranslational modification] 1322246008233 intermolecular recognition site; other site 1322246008234 dimerization interface [polypeptide binding]; other site 1322246008235 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1322246008236 DNA binding site [nucleotide binding] 1322246008237 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1322246008238 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1322246008239 inhibitor-cofactor binding pocket; inhibition site 1322246008240 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1322246008241 catalytic residue [active] 1322246008242 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 1322246008243 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 1322246008244 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 1322246008245 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 1322246008246 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; cl17726 1322246008247 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1322246008248 dimerization interface [polypeptide binding]; other site 1322246008249 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1322246008250 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 1322246008251 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14356 1322246008252 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1322246008253 Substrate binding site; other site 1322246008254 Mg++ binding site; other site 1322246008255 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 1322246008256 active site 1322246008257 substrate binding site [chemical binding]; other site 1322246008258 CoA binding site [chemical binding]; other site 1322246008259 Cell division protein ZapA; Region: ZapA; pfam05164 1322246008260 phosphodiesterase; Provisional; Region: PRK12704 1322246008261 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1322246008262 Zn2+ binding site [ion binding]; other site 1322246008263 Mg2+ binding site [ion binding]; other site 1322246008264 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 1322246008265 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 1322246008266 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 1322246008267 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 1322246008268 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1322246008269 putative active site [active] 1322246008270 metal binding site [ion binding]; metal-binding site 1322246008271 homodimer binding site [polypeptide binding]; other site 1322246008272 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1322246008273 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 1322246008274 active site 1322246008275 HIGH motif; other site 1322246008276 dimer interface [polypeptide binding]; other site 1322246008277 KMSKS motif; other site 1322246008278 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1322246008279 RNA binding surface [nucleotide binding]; other site 1322246008280 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 1322246008281 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1322246008282 Walker A/P-loop; other site 1322246008283 ATP binding site [chemical binding]; other site 1322246008284 ABC transporter; Region: ABC_tran; pfam00005 1322246008285 Q-loop/lid; other site 1322246008286 ABC transporter signature motif; other site 1322246008287 Walker B; other site 1322246008288 D-loop; other site 1322246008289 H-loop/switch region; other site 1322246008290 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1322246008291 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1322246008292 binding surface 1322246008293 TPR motif; other site 1322246008294 TPR repeat; Region: TPR_11; pfam13414 1322246008295 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1322246008296 non-specific DNA binding site [nucleotide binding]; other site 1322246008297 salt bridge; other site 1322246008298 sequence-specific DNA binding site [nucleotide binding]; other site 1322246008299 Cupin domain; Region: Cupin_2; pfam07883 1322246008300 AMP-binding domain protein; Validated; Region: PRK08315 1322246008301 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1322246008302 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 1322246008303 acyl-activating enzyme (AAE) consensus motif; other site 1322246008304 acyl-activating enzyme (AAE) consensus motif; other site 1322246008305 putative AMP binding site [chemical binding]; other site 1322246008306 putative active site [active] 1322246008307 putative CoA binding site [chemical binding]; other site 1322246008308 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1322246008309 non-specific DNA binding site [nucleotide binding]; other site 1322246008310 salt bridge; other site 1322246008311 sequence-specific DNA binding site [nucleotide binding]; other site 1322246008312 Cupin domain; Region: Cupin_2; pfam07883 1322246008313 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1322246008314 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 1322246008315 acyl-activating enzyme (AAE) consensus motif; other site 1322246008316 AMP binding site [chemical binding]; other site 1322246008317 active site 1322246008318 CoA binding site [chemical binding]; other site 1322246008319 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 1322246008320 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1322246008321 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 1322246008322 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1322246008323 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655 1322246008324 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 1322246008325 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 1322246008326 Flagellar hook-length control protein [Cell motility and secretion]; Region: FliK; COG3144 1322246008327 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 1322246008328 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1322246008329 Glycosyltransferase family 9 (heptosyltransferase); Region: Glyco_transf_9; pfam01075 1322246008330 putative active site [active] 1322246008331 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 1322246008332 DUF based on E. rectale Gene description (DUF3880); Region: DUF3880; pfam12996 1322246008333 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 1322246008334 Cache domain; Region: Cache_1; pfam02743 1322246008335 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1322246008336 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1322246008337 metal binding site [ion binding]; metal-binding site 1322246008338 active site 1322246008339 I-site; other site 1322246008340 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 1322246008341 putative active site [active] 1322246008342 dimerization interface [polypeptide binding]; other site 1322246008343 putative tRNAtyr binding site [nucleotide binding]; other site 1322246008344 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 1322246008345 active site 1322246008346 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537 1322246008347 homodimer interface [polypeptide binding]; other site 1322246008348 chemical substrate binding site [chemical binding]; other site 1322246008349 oligomer interface [polypeptide binding]; other site 1322246008350 metal binding site [ion binding]; metal-binding site 1322246008351 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 1322246008352 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 1322246008353 active site 1322246008354 PHP Thumb interface [polypeptide binding]; other site 1322246008355 metal binding site [ion binding]; metal-binding site 1322246008356 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1322246008357 generic binding surface II; other site 1322246008358 generic binding surface I; other site 1322246008359 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1322246008360 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1322246008361 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1322246008362 transmembrane helices; other site 1322246008363 Cache domain; Region: Cache_1; pfam02743 1322246008364 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1322246008365 dimer interface [polypeptide binding]; other site 1322246008366 phosphorylation site [posttranslational modification] 1322246008367 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1322246008368 ATP binding site [chemical binding]; other site 1322246008369 Mg2+ binding site [ion binding]; other site 1322246008370 G-X-G motif; other site 1322246008371 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1322246008372 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1322246008373 active site 1322246008374 phosphorylation site [posttranslational modification] 1322246008375 intermolecular recognition site; other site 1322246008376 dimerization interface [polypeptide binding]; other site 1322246008377 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 1322246008378 Amidinotransferase; Region: Amidinotransf; cl12043 1322246008379 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 1322246008380 AsmA family; Region: AsmA; pfam05170 1322246008381 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 1322246008382 Protein of unknown function (DUF4197); Region: DUF4197; pfam13852 1322246008383 Putative pyruvate format-lyase activating enzyme (DUF1786); Region: DUF1786; cl01638 1322246008384 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 1322246008385 Putative serine esterase (DUF676); Region: DUF676; pfam05057 1322246008386 HEAT repeats; Region: HEAT_2; pfam13646 1322246008387 Protein of unknown function (DUF2435); Region: DUF2435; pfam10363 1322246008388 HEAT repeats; Region: HEAT_2; pfam13646 1322246008389 HEAT repeats; Region: HEAT_2; pfam13646 1322246008390 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1322246008391 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1322246008392 active site 1322246008393 phosphorylation site [posttranslational modification] 1322246008394 intermolecular recognition site; other site 1322246008395 dimerization interface [polypeptide binding]; other site 1322246008396 Predicted inhibitor of MCP methylation, homolog of CheC [Cell motility and secretion]; Region: COG1406 1322246008397 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 1322246008398 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1322246008399 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1322246008400 Predicted permeases [General function prediction only]; Region: COG0679 1322246008401 Protein of unknown function (DUF554); Region: DUF554; pfam04474 1322246008402 integrase; Provisional; Region: PRK09692 1322246008403 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 1322246008404 active site 1322246008405 Int/Topo IB signature motif; other site 1322246008406 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 1322246008407 Replicase family; Region: Replicase; pfam03090 1322246008408 Predicted helicase [General function prediction only]; Region: COG4889 1322246008409 Restriction endonuclease; Region: Mrr_cat_2; pfam13156 1322246008410 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1322246008411 ATP binding site [chemical binding]; other site 1322246008412 putative Mg++ binding site [ion binding]; other site 1322246008413 Helicase conserved C-terminal domain; Region: Helicase_C; pfam00271 1322246008414 ATP-binding site [chemical binding]; other site 1322246008415 CHASE domain; Region: CHASE; cl01369 1322246008416 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1322246008417 PAS fold; Region: PAS_3; pfam08447 1322246008418 putative active site [active] 1322246008419 heme pocket [chemical binding]; other site 1322246008420 PAS domain S-box; Region: sensory_box; TIGR00229 1322246008421 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1322246008422 putative active site [active] 1322246008423 heme pocket [chemical binding]; other site 1322246008424 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1322246008425 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1322246008426 metal binding site [ion binding]; metal-binding site 1322246008427 active site 1322246008428 I-site; other site 1322246008429 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1322246008430 dimerization interface [polypeptide binding]; other site 1322246008431 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1322246008432 dimer interface [polypeptide binding]; other site 1322246008433 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 1322246008434 putative CheW interface [polypeptide binding]; other site 1322246008435 sulfite reductase, dissimilatory-type alpha subunit; Region: dsrA; TIGR02064 1322246008436 sulfite reductase, dissimilatory-type beta subunit; Region: dsrB; TIGR02066 1322246008437 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1322246008438 Dissimilatory sulfite reductase D (DsrD); Region: DsrD; pfam08679 1322246008439 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 1322246008440 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 1322246008441 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 1322246008442 catalytic triad [active] 1322246008443 Uncharacterized membrane protein, required for N-linked glycosylation [General function prediction only]; Region: COG1287 1322246008444 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1322246008445 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1322246008446 inhibitor-cofactor binding pocket; inhibition site 1322246008447 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1322246008448 catalytic residue [active] 1322246008449 TPR repeat; Region: TPR_11; pfam13414 1322246008450 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1322246008451 binding surface 1322246008452 TPR motif; other site 1322246008453 TPR repeat; Region: TPR_11; pfam13414 1322246008454 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1322246008455 binding surface 1322246008456 TPR motif; other site 1322246008457 TPR repeat; Region: TPR_11; pfam13414 1322246008458 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 1322246008459 substrate binding site [chemical binding]; other site 1322246008460 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1322246008461 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1322246008462 Walker A/P-loop; other site 1322246008463 ATP binding site [chemical binding]; other site 1322246008464 Q-loop/lid; other site 1322246008465 ABC transporter signature motif; other site 1322246008466 Walker B; other site 1322246008467 D-loop; other site 1322246008468 H-loop/switch region; other site 1322246008469 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1322246008470 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1322246008471 Walker A/P-loop; other site 1322246008472 ATP binding site [chemical binding]; other site 1322246008473 Q-loop/lid; other site 1322246008474 ABC transporter signature motif; other site 1322246008475 Walker B; other site 1322246008476 D-loop; other site 1322246008477 H-loop/switch region; other site 1322246008478 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1322246008479 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1322246008480 TM-ABC transporter signature motif; other site 1322246008481 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1322246008482 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1322246008483 TM-ABC transporter signature motif; other site 1322246008484 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1322246008485 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 1322246008486 putative ligand binding site [chemical binding]; other site 1322246008487 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 1322246008488 ligand-binding site [chemical binding]; other site 1322246008489 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06710 1322246008490 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 1322246008491 acyl-activating enzyme (AAE) consensus motif; other site 1322246008492 putative AMP binding site [chemical binding]; other site 1322246008493 putative active site [active] 1322246008494 putative CoA binding site [chemical binding]; other site 1322246008495 putative DNA binding site [nucleotide binding]; other site 1322246008496 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 1322246008497 putative Zn2+ binding site [ion binding]; other site 1322246008498 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1322246008499 N-acetylneuraminate synthase; Region: NeuB_NnaB; TIGR03569 1322246008500 NeuB family; Region: NeuB; pfam03102 1322246008501 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 1322246008502 NeuB binding interface [polypeptide binding]; other site 1322246008503 putative substrate binding site [chemical binding]; other site 1322246008504 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 1322246008505 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1322246008506 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1322246008507 active site 1322246008508 phosphorylation site [posttranslational modification] 1322246008509 intermolecular recognition site; other site 1322246008510 dimerization interface [polypeptide binding]; other site 1322246008511 Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; pfam10087 1322246008512 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 1322246008513 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1322246008514 MarR family; Region: MarR; pfam01047 1322246008515 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1322246008516 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1322246008517 ring oligomerisation interface [polypeptide binding]; other site 1322246008518 ATP/Mg binding site [chemical binding]; other site 1322246008519 stacking interactions; other site 1322246008520 hinge regions; other site 1322246008521 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1322246008522 oligomerisation interface [polypeptide binding]; other site 1322246008523 mobile loop; other site 1322246008524 roof hairpin; other site 1322246008525 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 1322246008526 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 1322246008527 active site 1322246008528 homotetramer interface [polypeptide binding]; other site 1322246008529 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1322246008530 PAS fold; Region: PAS_3; pfam08447 1322246008531 putative active site [active] 1322246008532 heme pocket [chemical binding]; other site 1322246008533 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1322246008534 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1322246008535 metal binding site [ion binding]; metal-binding site 1322246008536 active site 1322246008537 I-site; other site 1322246008538 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1322246008539 NlpC/P60 family; Region: NLPC_P60; pfam00877 1322246008540 outer membrane lipoprotein; Provisional; Region: PRK11023 1322246008541 BON domain; Region: BON; pfam04972 1322246008542 BON domain; Region: BON; pfam04972 1322246008543 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1322246008544 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1322246008545 RNA binding surface [nucleotide binding]; other site 1322246008546 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1322246008547 active site 1322246008548 DctM-like transporters; Region: DctM; pfam06808 1322246008549 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 1322246008550 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 1322246008551 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 1322246008552 Family description; Region: VCBS; pfam13517 1322246008553 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 1322246008554 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 1322246008555 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1322246008556 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1322246008557 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1322246008558 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1322246008559 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1322246008560 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1322246008561 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1322246008562 active site 1322246008563 Int/Topo IB signature motif; other site 1322246008564 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1322246008565 dimerization interface [polypeptide binding]; other site 1322246008566 putative DNA binding site [nucleotide binding]; other site 1322246008567 putative Zn2+ binding site [ion binding]; other site 1322246008568 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1322246008569 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1322246008570 Walker A/P-loop; other site 1322246008571 ATP binding site [chemical binding]; other site 1322246008572 Q-loop/lid; other site 1322246008573 ABC transporter signature motif; other site 1322246008574 Walker B; other site 1322246008575 D-loop; other site 1322246008576 H-loop/switch region; other site 1322246008577 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1322246008578 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1322246008579 S-adenosylmethionine binding site [chemical binding]; other site 1322246008580 N-acetylneuraminate synthase; Region: NeuB_NnaB; TIGR03569 1322246008581 NeuB family; Region: NeuB; pfam03102 1322246008582 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 1322246008583 NeuB binding interface [polypeptide binding]; other site 1322246008584 putative substrate binding site [chemical binding]; other site 1322246008585 UDP-N-acetyl-D-glucosamine 2-epimerase, UDP-hydrolysing; Region: NeuC_NnaA; TIGR03568 1322246008586 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 1322246008587 active site 1322246008588 homodimer interface [polypeptide binding]; other site 1322246008589 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1322246008590 S-adenosylmethionine binding site [chemical binding]; other site 1322246008591 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1322246008592 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1322246008593 NAD binding site [chemical binding]; other site 1322246008594 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1322246008595 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 1322246008596 ligand binding site; other site 1322246008597 tetramer interface; other site 1322246008598 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsS; COG3562 1322246008599 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1322246008600 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 1322246008601 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1322246008602 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 1322246008603 putative ADP-binding pocket [chemical binding]; other site 1322246008604 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 1322246008605 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1322246008606 active site 1322246008607 dimer interface [polypeptide binding]; other site 1322246008608 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1322246008609 Ligand Binding Site [chemical binding]; other site 1322246008610 Molecular Tunnel; other site 1322246008611 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1322246008612 This family is most closely related to the GT1 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis; Region: GT1_WbnK_like; cd03807 1322246008613 putative ADP-binding pocket [chemical binding]; other site 1322246008614 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 1322246008615 Transposase IS200 like; Region: Y1_Tnp; pfam01797 1322246008616 B12 binding domain; Region: B12-binding; pfam02310 1322246008617 B12 binding site [chemical binding]; other site 1322246008618 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 1322246008619 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1322246008620 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1322246008621 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1322246008622 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1322246008623 Coenzyme A binding pocket [chemical binding]; other site 1322246008624 RimK-like ATPgrasp N-terminal domain; Region: RLAN; pfam14401 1322246008625 Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) [Coenzyme metabolism / Translation, ribosomal structure and biogenesis]; Region: RimK; COG0189 1322246008626 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1322246008627 SET domain; Region: SET; pfam00856 1322246008628 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1322246008629 Coenzyme A binding pocket [chemical binding]; other site 1322246008630 Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574 1322246008631 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1322246008632 putative active site [active] 1322246008633 catalytic triad [active] 1322246008634 putative dimer interface [polypeptide binding]; other site 1322246008635 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1322246008636 Thermotoga maritima CorA_like subfamily; Region: TmCorA-like_1; cd12828 1322246008637 oligomer interface [polypeptide binding]; other site 1322246008638 metal binding site [ion binding]; metal-binding site 1322246008639 metal binding site [ion binding]; metal-binding site 1322246008640 Cl binding site [ion binding]; other site 1322246008641 aspartate ring; other site 1322246008642 basic sphincter; other site 1322246008643 putative hydrophobic gate; other site 1322246008644 periplasmic entrance; other site 1322246008645 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1322246008646 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1322246008647 Domain of unknown function DUF21; Region: DUF21; pfam01595 1322246008648 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1322246008649 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1322246008650 dimerization interface [polypeptide binding]; other site 1322246008651 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1322246008652 cyclase homology domain; Region: CHD; cd07302 1322246008653 nucleotidyl binding site; other site 1322246008654 metal binding site [ion binding]; metal-binding site 1322246008655 dimer interface [polypeptide binding]; other site 1322246008656 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1322246008657 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1322246008658 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 1322246008659 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1322246008660 dimerization interface [polypeptide binding]; other site 1322246008661 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1322246008662 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1322246008663 dimer interface [polypeptide binding]; other site 1322246008664 putative CheW interface [polypeptide binding]; other site 1322246008665 TMAO reductase system periplasmic protein TorT; Provisional; Region: PRK10936 1322246008666 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1322246008667 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 1322246008668 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 1322246008669 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1322246008670 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1322246008671 dimerization interface [polypeptide binding]; other site 1322246008672 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1322246008673 dimer interface [polypeptide binding]; other site 1322246008674 phosphorylation site [posttranslational modification] 1322246008675 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1322246008676 ATP binding site [chemical binding]; other site 1322246008677 Mg2+ binding site [ion binding]; other site 1322246008678 G-X-G motif; other site 1322246008679 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1322246008680 dimer interface [polypeptide binding]; other site 1322246008681 conserved gate region; other site 1322246008682 putative PBP binding loops; other site 1322246008683 ABC-ATPase subunit interface; other site 1322246008684 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1322246008685 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1322246008686 dimer interface [polypeptide binding]; other site 1322246008687 conserved gate region; other site 1322246008688 putative PBP binding loops; other site 1322246008689 ABC-ATPase subunit interface; other site 1322246008690 hypothetical protein; Provisional; Region: PRK11622 1322246008691 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4134 1322246008692 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1322246008693 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 1322246008694 Walker A/P-loop; other site 1322246008695 ATP binding site [chemical binding]; other site 1322246008696 Q-loop/lid; other site 1322246008697 ABC transporter signature motif; other site 1322246008698 Walker B; other site 1322246008699 D-loop; other site 1322246008700 H-loop/switch region; other site 1322246008701 TOBE domain; Region: TOBE_2; pfam08402 1322246008702 Phosphotransferase enzyme family; Region: APH; pfam01636 1322246008703 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1322246008704 active site 1322246008705 ATP binding site [chemical binding]; other site 1322246008706 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1322246008707 dimerization interface [polypeptide binding]; other site 1322246008708 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1322246008709 dimer interface [polypeptide binding]; other site 1322246008710 phosphorylation site [posttranslational modification] 1322246008711 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1322246008712 ATP binding site [chemical binding]; other site 1322246008713 Mg2+ binding site [ion binding]; other site 1322246008714 G-X-G motif; other site 1322246008715 Response regulator receiver domain; Region: Response_reg; pfam00072 1322246008716 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1322246008717 active site 1322246008718 phosphorylation site [posttranslational modification] 1322246008719 intermolecular recognition site; other site 1322246008720 dimerization interface [polypeptide binding]; other site 1322246008721 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1322246008722 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1322246008723 active site 1322246008724 phosphorylation site [posttranslational modification] 1322246008725 intermolecular recognition site; other site 1322246008726 dimerization interface [polypeptide binding]; other site 1322246008727 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1322246008728 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1322246008729 active site 1322246008730 phosphorylation site [posttranslational modification] 1322246008731 intermolecular recognition site; other site 1322246008732 dimerization interface [polypeptide binding]; other site 1322246008733 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 1322246008734 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 1322246008735 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 1322246008736 Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201 1322246008737 CheB methylesterase; Region: CheB_methylest; pfam01339 1322246008738 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1322246008739 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1322246008740 active site 1322246008741 phosphorylation site [posttranslational modification] 1322246008742 intermolecular recognition site; other site 1322246008743 dimerization interface [polypeptide binding]; other site 1322246008744 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1322246008745 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1322246008746 metal binding site [ion binding]; metal-binding site 1322246008747 active site 1322246008748 I-site; other site 1322246008749 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1322246008750 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1322246008751 TM-ABC transporter signature motif; other site 1322246008752 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1322246008753 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1322246008754 TM-ABC transporter signature motif; other site 1322246008755 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1322246008756 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1322246008757 Walker A/P-loop; other site 1322246008758 ATP binding site [chemical binding]; other site 1322246008759 Q-loop/lid; other site 1322246008760 ABC transporter signature motif; other site 1322246008761 Walker B; other site 1322246008762 D-loop; other site 1322246008763 H-loop/switch region; other site 1322246008764 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1322246008765 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 1322246008766 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1322246008767 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1322246008768 Radical SAM superfamily; Region: Radical_SAM; pfam04055 1322246008769 FeS/SAM binding site; other site 1322246008770 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 1322246008771 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1322246008772 23S rRNA interface [nucleotide binding]; other site 1322246008773 L3 interface [polypeptide binding]; other site 1322246008774 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1322246008775 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1322246008776 motif 1; other site 1322246008777 active site 1322246008778 motif 2; other site 1322246008779 motif 3; other site 1322246008780 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1322246008781 DHHA1 domain; Region: DHHA1; pfam02272 1322246008782 recombinase A; Provisional; Region: recA; PRK09354 1322246008783 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1322246008784 hexamer interface [polypeptide binding]; other site 1322246008785 Walker A motif; other site 1322246008786 ATP binding site [chemical binding]; other site 1322246008787 Walker B motif; other site 1322246008788 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 1322246008789 Ligand Binding Site [chemical binding]; other site 1322246008790 Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530 1322246008791 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1322246008792 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1322246008793 ribonuclease R; Region: RNase_R; TIGR02063 1322246008794 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 1322246008795 RNB domain; Region: RNB; pfam00773 1322246008796 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 1322246008797 RNA binding site [nucleotide binding]; other site 1322246008798 Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; pfam02606 1322246008799 tetraacyldisaccharide 4'-kinase; Region: lpxK; TIGR00682 1322246008800 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 1322246008801 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 1322246008802 hypothetical protein; Provisional; Region: PRK11770 1322246008803 Domain of unknown function (DUF307); Region: DUF307; pfam03733 1322246008804 Domain of unknown function (DUF307); Region: DUF307; pfam03733 1322246008805 Bacteriophage CI repressor helix-turn-helix domain; Region: Phage_CI_repr; pfam07022 1322246008806 Predicted transcriptional regulator [Transcription]; Region: COG2932 1322246008807 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1322246008808 Catalytic site [active] 1322246008809 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1322246008810 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1322246008811 active site 1322246008812 phosphorylation site [posttranslational modification] 1322246008813 intermolecular recognition site; other site 1322246008814 dimerization interface [polypeptide binding]; other site 1322246008815 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1322246008816 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1322246008817 metal binding site [ion binding]; metal-binding site 1322246008818 active site 1322246008819 I-site; other site 1322246008820 Uncharacterized conserved protein [Function unknown]; Region: COG5316 1322246008821 N-terminal domain of unknown function (DUF4140); Region: DUF4140; pfam13600 1322246008822 Domain of unknown function (DUF4139); Region: DUF4139; pfam13598 1322246008823 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 1322246008824 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1322246008825 motif II; other site 1322246008826 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 1322246008827 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 1322246008828 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 1322246008829 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 1322246008830 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 1322246008831 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 1322246008832 CoA binding domain; Region: CoA_binding_2; pfam13380 1322246008833 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 1322246008834 GTP-binding protein YchF; Reviewed; Region: PRK09601 1322246008835 YchF GTPase; Region: YchF; cd01900 1322246008836 G1 box; other site 1322246008837 GTP/Mg2+ binding site [chemical binding]; other site 1322246008838 Switch I region; other site 1322246008839 G2 box; other site 1322246008840 Switch II region; other site 1322246008841 G3 box; other site 1322246008842 G4 box; other site 1322246008843 G5 box; other site 1322246008844 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1322246008845 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 1322246008846 active site 1322246008847 zinc binding site [ion binding]; other site 1322246008848 Na+ binding site [ion binding]; other site 1322246008849 chaperone protein DnaJ; Provisional; Region: PRK14279 1322246008850 Response regulator receiver domain; Region: Response_reg; pfam00072 1322246008851 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1322246008852 active site 1322246008853 phosphorylation site [posttranslational modification] 1322246008854 intermolecular recognition site; other site 1322246008855 dimerization interface [polypeptide binding]; other site 1322246008856 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1322246008857 dimerization interface [polypeptide binding]; other site 1322246008858 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1322246008859 dimer interface [polypeptide binding]; other site 1322246008860 phosphorylation site [posttranslational modification] 1322246008861 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1322246008862 ATP binding site [chemical binding]; other site 1322246008863 Mg2+ binding site [ion binding]; other site 1322246008864 G-X-G motif; other site 1322246008865 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1322246008866 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1322246008867 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 1322246008868 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1322246008869 active site 1322246008870 HIGH motif; other site 1322246008871 nucleotide binding site [chemical binding]; other site 1322246008872 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 1322246008873 KMSKS motif; other site 1322246008874 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 1322246008875 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1322246008876 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1322246008877 substrate binding pocket [chemical binding]; other site 1322246008878 membrane-bound complex binding site; other site 1322246008879 hinge residues; other site 1322246008880 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 1322246008881 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 1322246008882 CoA binding domain; Region: CoA_binding_2; pfam13380 1322246008883 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 1322246008884 Nif-specific regulatory protein; Region: nifA; TIGR01817 1322246008885 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1322246008886 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1322246008887 Walker A motif; other site 1322246008888 ATP binding site [chemical binding]; other site 1322246008889 Walker B motif; other site 1322246008890 arginine finger; other site 1322246008891 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1322246008892 XXXCH domain; Region: XXXCH_domain; TIGR04358 1322246008893 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 1322246008894 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 1322246008895 phosphate binding site [ion binding]; other site 1322246008896 putative substrate binding pocket [chemical binding]; other site 1322246008897 dimer interface [polypeptide binding]; other site 1322246008898 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR6; cd08272 1322246008899 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1322246008900 putative NAD(P) binding site [chemical binding]; other site 1322246008901 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39_likeD; cd02421 1322246008902 type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375 1322246008903 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1322246008904 ATP-binding cassette domain of bacteriocin exporters, subfamily C; Region: ABCC_bacteriocin_exporters; cd03245 1322246008905 Walker A/P-loop; other site 1322246008906 ATP binding site [chemical binding]; other site 1322246008907 Q-loop/lid; other site 1322246008908 ABC transporter signature motif; other site 1322246008909 Walker B; other site 1322246008910 D-loop; other site 1322246008911 H-loop/switch region; other site 1322246008912 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 1322246008913 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1322246008914 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1322246008915 HlyD family secretion protein; Region: HlyD_3; pfam13437 1322246008916 Bacterial transglutaminase-like cysteine proteinase BTLCP; Region: BTLCP; cl17596 1322246008917 PAS fold; Region: PAS_4; pfam08448 1322246008918 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1322246008919 putative active site [active] 1322246008920 heme pocket [chemical binding]; other site 1322246008921 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1322246008922 Zn2+ binding site [ion binding]; other site 1322246008923 Mg2+ binding site [ion binding]; other site 1322246008924 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 1322246008925 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1322246008926 HlyD family secretion protein; Region: HlyD_3; pfam13437 1322246008927 Domain of unknown function (DUF1844); Region: DUF1844; pfam08899 1322246008928 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 1322246008929 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1322246008930 VacJ like lipoprotein; Region: VacJ; cl01073 1322246008931 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1322246008932 GTP-binding protein LepA; Provisional; Region: PRK05433 1322246008933 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1322246008934 G1 box; other site 1322246008935 putative GEF interaction site [polypeptide binding]; other site 1322246008936 GTP/Mg2+ binding site [chemical binding]; other site 1322246008937 Switch I region; other site 1322246008938 G2 box; other site 1322246008939 G3 box; other site 1322246008940 Switch II region; other site 1322246008941 G4 box; other site 1322246008942 G5 box; other site 1322246008943 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 1322246008944 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1322246008945 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1322246008946 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1322246008947 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1322246008948 Catalytic site [active] 1322246008949 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1322246008950 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1322246008951 substrate binding pocket [chemical binding]; other site 1322246008952 membrane-bound complex binding site; other site 1322246008953 hinge residues; other site 1322246008954 Domain of unknown function (DUF697); Region: DUF697; cl12064 1322246008955 3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353 1322246008956 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 1322246008957 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 1322246008958 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 1322246008959 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1322246008960 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1322246008961 PAS domain; Region: PAS_9; pfam13426 1322246008962 putative active site [active] 1322246008963 heme pocket [chemical binding]; other site 1322246008964 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1322246008965 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1322246008966 Walker A motif; other site 1322246008967 ATP binding site [chemical binding]; other site 1322246008968 Walker B motif; other site 1322246008969 arginine finger; other site 1322246008970 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 1322246008971 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 1322246008972 aspartate aminotransferase; Provisional; Region: PRK06836 1322246008973 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1322246008974 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1322246008975 homodimer interface [polypeptide binding]; other site 1322246008976 catalytic residue [active] 1322246008977 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 1322246008978 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 1322246008979 tandem repeat interface [polypeptide binding]; other site 1322246008980 oligomer interface [polypeptide binding]; other site 1322246008981 active site residues [active] 1322246008982 cobalamin synthase; Reviewed; Region: cobS; PRK00235 1322246008983 S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887 1322246008984 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1322246008985 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1322246008986 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1322246008987 4Fe-4S binding domain; Region: Fer4_5; pfam12801 1322246008988 Ferredoxin [Energy production and conversion]; Region: NapF; COG1145 1322246008989 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 1322246008990 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1322246008991 FOG: CBS domain [General function prediction only]; Region: COG0517 1322246008992 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1322246008993 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1322246008994 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 1322246008995 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 1322246008996 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1322246008997 active site 1322246008998 shikimate kinase; Reviewed; Region: aroK; PRK00131 1322246008999 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1322246009000 ADP binding site [chemical binding]; other site 1322246009001 magnesium binding site [ion binding]; other site 1322246009002 putative shikimate binding site; other site 1322246009003 NMT1/THI5 like; Region: NMT1; pfam09084 1322246009004 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1322246009005 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1322246009006 dimer interface [polypeptide binding]; other site 1322246009007 phosphorylation site [posttranslational modification] 1322246009008 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1322246009009 ATP binding site [chemical binding]; other site 1322246009010 Mg2+ binding site [ion binding]; other site 1322246009011 G-X-G motif; other site 1322246009012 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1322246009013 Seven times multi-haem cytochrome CxxCH; Region: Multi-haem_cyto; pfam13447 1322246009014 NapC/NirT cytochrome c family, N-terminal region; Region: Cytochrom_NNT; pfam03264 1322246009015 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 1322246009016 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 1322246009017 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1322246009018 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1322246009019 dimer interface [polypeptide binding]; other site 1322246009020 phosphorylation site [posttranslational modification] 1322246009021 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1322246009022 ATP binding site [chemical binding]; other site 1322246009023 Mg2+ binding site [ion binding]; other site 1322246009024 G-X-G motif; other site 1322246009025 Response regulator receiver domain; Region: Response_reg; pfam00072 1322246009026 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1322246009027 active site 1322246009028 phosphorylation site [posttranslational modification] 1322246009029 intermolecular recognition site; other site 1322246009030 dimerization interface [polypeptide binding]; other site 1322246009031 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1322246009032 putative binding surface; other site 1322246009033 active site 1322246009034 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1322246009035 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1322246009036 active site 1322246009037 phosphorylation site [posttranslational modification] 1322246009038 intermolecular recognition site; other site 1322246009039 dimerization interface [polypeptide binding]; other site 1322246009040 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1322246009041 Walker A motif; other site 1322246009042 ATP binding site [chemical binding]; other site 1322246009043 Walker B motif; other site 1322246009044 arginine finger; other site 1322246009045 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1322246009046 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1322246009047 dimer interface [polypeptide binding]; other site 1322246009048 putative CheW interface [polypeptide binding]; other site 1322246009049 Hemerythrin; Region: Hemerythrin; cd12107 1322246009050 Fe binding site [ion binding]; other site 1322246009051 Hemerythrin; Region: Hemerythrin; cd12107 1322246009052 Fe binding site [ion binding]; other site 1322246009053 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 1322246009054 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 1322246009055 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 1322246009056 putative dimer interface [polypeptide binding]; other site 1322246009057 active site pocket [active] 1322246009058 putative cataytic base [active] 1322246009059 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 1322246009060 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 1322246009061 domain interfaces; other site 1322246009062 active site 1322246009063 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1322246009064 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1322246009065 binding surface 1322246009066 TPR motif; other site 1322246009067 TPR repeat; Region: TPR_11; pfam13414 1322246009068 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1322246009069 binding surface 1322246009070 TPR motif; other site 1322246009071 TPR repeat; Region: TPR_11; pfam13414 1322246009072 TPR repeat; Region: TPR_11; pfam13414 1322246009073 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1322246009074 binding surface 1322246009075 TPR motif; other site 1322246009076 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1322246009077 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1322246009078 TPR repeat; Region: TPR_11; pfam13414 1322246009079 binding surface 1322246009080 TPR motif; other site 1322246009081 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 1322246009082 Found in ATP-dependent protease La (LON); Region: LON; smart00464 1322246009083 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1322246009084 Walker A motif; other site 1322246009085 ATP binding site [chemical binding]; other site 1322246009086 Walker B motif; other site 1322246009087 arginine finger; other site 1322246009088 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1322246009089 Acylphosphatase; Region: Acylphosphatase; pfam00708 1322246009090 DNA repair proteins [DNA replication, recombination, and repair]; Region: RadC; COG2003 1322246009091 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 1322246009092 MPN+ (JAMM) motif; other site 1322246009093 Zinc-binding site [ion binding]; other site 1322246009094 DNA polymerase III, delta subunit [DNA replication, recombination, and repair]; Region: HolA; COG1466 1322246009095 molybdate ABC transporter periplasmic substrate-binding protein; Provisional; Region: PRK04168 1322246009096 tungstate ABC transporter binding protein WtpA; Region: tungstate_WtpA; TIGR03730 1322246009097 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1322246009098 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1322246009099 HIGH motif; other site 1322246009100 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1322246009101 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1322246009102 active site 1322246009103 KMSKS motif; other site 1322246009104 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1322246009105 tRNA binding surface [nucleotide binding]; other site 1322246009106 transcription antitermination factor NusB; Region: nusB; TIGR01951 1322246009107 putative RNA binding site [nucleotide binding]; other site 1322246009108 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 1322246009109 homopentamer interface [polypeptide binding]; other site 1322246009110 active site 1322246009111 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 1322246009112 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 1322246009113 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 1322246009114 dimerization interface [polypeptide binding]; other site 1322246009115 active site 1322246009116 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 1322246009117 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1322246009118 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1322246009119 metal binding site [ion binding]; metal-binding site 1322246009120 active site 1322246009121 I-site; other site 1322246009122 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1322246009123 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK08270 1322246009124 ATP cone domain; Region: ATP-cone; pfam03477 1322246009125 Class III ribonucleotide reductase; Region: RNR_III; cd01675 1322246009126 effector binding site; other site 1322246009127 active site 1322246009128 Zn binding site [ion binding]; other site 1322246009129 glycine loop; other site 1322246009130 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1322246009131 Radical SAM superfamily; Region: Radical_SAM; pfam04055 1322246009132 FeS/SAM binding site; other site 1322246009133 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1322246009134 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1322246009135 putative active site [active] 1322246009136 putative metal binding site [ion binding]; other site 1322246009137 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1322246009138 transmembrane helices; other site 1322246009139 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1322246009140 TrkA-C domain; Region: TrkA_C; pfam02080 1322246009141 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 1322246009142 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1322246009143 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1322246009144 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1322246009145 DNA-binding site [nucleotide binding]; DNA binding site 1322246009146 FCD domain; Region: FCD; pfam07729 1322246009147 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 1322246009148 active site 1322246009149 substrate binding site [chemical binding]; other site 1322246009150 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 1322246009151 FMN binding site [chemical binding]; other site 1322246009152 putative catalytic residues [active] 1322246009153 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1322246009154 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_7; cd13133 1322246009155 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1322246009156 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 1322246009157 VCBS repeat; Region: VCBS_repeat; TIGR01965 1322246009158 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 1322246009159 Ca2+ binding site [ion binding]; other site 1322246009160 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 1322246009161 Ca2+ binding site [ion binding]; other site 1322246009162 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 1322246009163 Ca2+ binding site [ion binding]; other site 1322246009164 choice-of-anchor C domain; Region: choice_anch_C; TIGR04362 1322246009165 4Fe-4S binding domain; Region: Fer4; pfam00037 1322246009166 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 1322246009167 Nitroreductase family. Members of this family utilize FMN as a cofactor. This family is involved in the reduction of flavin or nitroaromatic compounds by using NAD(P)H as electron donor in a obligatory two-electron transfer. Nitrogenase is homodimer; Region: NADH_nitroreductase; cd02143 1322246009168 putative FMN binding site [chemical binding]; other site 1322246009169 CHASE2 domain; Region: CHASE2; pfam05226 1322246009170 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 1322246009171 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1322246009172 cyclase homology domain; Region: CHD; cd07302 1322246009173 nucleotidyl binding site; other site 1322246009174 metal binding site [ion binding]; metal-binding site 1322246009175 dimer interface [polypeptide binding]; other site 1322246009176 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1322246009177 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1322246009178 active site 1322246009179 catalytic residues [active] 1322246009180 DNA binding site [nucleotide binding] 1322246009181 Int/Topo IB signature motif; other site 1322246009182 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1322246009183 active site 1322246009184 catalytic residues [active] 1322246009185 Int/Topo IB signature motif; other site 1322246009186 DNA binding site [nucleotide binding] 1322246009187 Protein of unknown function (DUF4011); Region: DUF4011; pfam13195 1322246009188 Part of AAA domain; Region: AAA_19; pfam13245 1322246009189 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 1322246009190 AAA domain; Region: AAA_30; pfam13604 1322246009191 AAA domain; Region: AAA_12; pfam13087 1322246009192 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 1322246009193 putative active site [active] 1322246009194 Protein of unknown function (DUF3320); Region: DUF3320; pfam11784 1322246009195 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1322246009196 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074 1322246009197 Family description; Region: UvrD_C_2; pfam13538 1322246009198 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1322246009199 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 1322246009200 Predicted transcriptional regulator [Transcription]; Region: COG2378 1322246009201 WYL domain; Region: WYL; pfam13280 1322246009202 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1322246009203 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1322246009204 Walker A motif; other site 1322246009205 ATP binding site [chemical binding]; other site 1322246009206 Walker B motif; other site 1322246009207 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1322246009208 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1322246009209 Walker A motif; other site 1322246009210 ATP binding site [chemical binding]; other site 1322246009211 Walker B motif; other site 1322246009212 arginine finger; other site 1322246009213 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 1322246009214 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1322246009215 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1322246009216 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1322246009217 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1322246009218 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 1322246009219 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 1322246009220 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1322246009221 dimer interface [polypeptide binding]; other site 1322246009222 phosphorylation site [posttranslational modification] 1322246009223 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1322246009224 ATP binding site [chemical binding]; other site 1322246009225 Mg2+ binding site [ion binding]; other site 1322246009226 G-X-G motif; other site 1322246009227 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1322246009228 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1322246009229 active site 1322246009230 phosphorylation site [posttranslational modification] 1322246009231 intermolecular recognition site; other site 1322246009232 dimerization interface [polypeptide binding]; other site 1322246009233 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1322246009234 Walker A motif; other site 1322246009235 ATP binding site [chemical binding]; other site 1322246009236 Walker B motif; other site 1322246009237 arginine finger; other site 1322246009238 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1322246009239 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1322246009240 Ligand Binding Site [chemical binding]; other site 1322246009241 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1322246009242 Putative transmembrane protein (Alph_Pro_TM); Region: Alph_Pro_TM; cl09826 1322246009243 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1322246009244 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1322246009245 Response regulator receiver domain; Region: Response_reg; pfam00072 1322246009246 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1322246009247 active site 1322246009248 phosphorylation site [posttranslational modification] 1322246009249 intermolecular recognition site; other site 1322246009250 dimerization interface [polypeptide binding]; other site 1322246009251 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1322246009252 Ligand Binding Site [chemical binding]; other site 1322246009253 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1322246009254 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1322246009255 active site 1322246009256 metal binding site [ion binding]; metal-binding site 1322246009257 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1322246009258 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1322246009259 dimer interface [polypeptide binding]; other site 1322246009260 putative CheW interface [polypeptide binding]; other site 1322246009261 Uncharacterized ArCR, COG2043; Region: DUF169; pfam02596 1322246009262 Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467 1322246009263 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 1322246009264 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 1322246009265 catalytic triad [active] 1322246009266 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 1322246009267 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 1322246009268 tetramer interface [polypeptide binding]; other site 1322246009269 heme binding pocket [chemical binding]; other site 1322246009270 NADPH binding site [chemical binding]; other site 1322246009271 TSCPD domain; Region: TSCPD; cl14834 1322246009272 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_1; cd06251 1322246009273 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 1322246009274 putative active site [active] 1322246009275 Zn binding site [ion binding]; other site 1322246009276 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 1322246009277 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1322246009278 Uncharacterized protein conserved in archaea [Posttranslational modification, protein turnover, chaperones]; Region: COG4067 1322246009279 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1322246009280 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1322246009281 Thermotoga maritima CorA_like subfamily; Region: TmCorA-like_1; cd12828 1322246009282 oligomer interface [polypeptide binding]; other site 1322246009283 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 1322246009284 metal binding site [ion binding]; metal-binding site 1322246009285 metal binding site [ion binding]; metal-binding site 1322246009286 Cl binding site [ion binding]; other site 1322246009287 aspartate ring; other site 1322246009288 putative hydrophobic gate; other site 1322246009289 periplasmic entrance; other site 1322246009290 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 1322246009291 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1322246009292 active site 1322246009293 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 1322246009294 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1322246009295 binding surface 1322246009296 TPR motif; other site 1322246009297 TPR repeat; Region: TPR_11; pfam13414 1322246009298 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1322246009299 binding surface 1322246009300 TPR motif; other site 1322246009301 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1322246009302 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1322246009303 TPR motif; other site 1322246009304 binding surface 1322246009305 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 1322246009306 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1322246009307 binding surface 1322246009308 TPR motif; other site 1322246009309 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1322246009310 TPR motif; other site 1322246009311 binding surface 1322246009312 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1322246009313 binding surface 1322246009314 TPR motif; other site 1322246009315 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1322246009316 TPR motif; other site 1322246009317 binding surface 1322246009318 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1322246009319 binding surface 1322246009320 TPR motif; other site 1322246009321 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 1322246009322 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1322246009323 Predicted membrane protein [Function unknown]; Region: COG4083; cl15694 1322246009324 exosortase D, VPLPA-CTERM-specific; Region: exosort_VPLPA; TIGR04152 1322246009325 Protein of unknown function (DUF3485); Region: DUF3485; pfam11984 1322246009326 VPLPA-CTERM protein sorting domain; Region: VPLPA-CTERM; TIGR03370 1322246009327 putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015 1322246009328 AAA domain; Region: AAA_14; pfam13173 1322246009329 exopolysaccharide/PEP-CTERM locus tyrosine autokinase; Region: pepcterm_TyrKin; TIGR03018 1322246009330 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1322246009331 polysaccharide chain length determinant protein, PEP-CTERM locus subfamily; Region: pepcterm_ChnLen; TIGR03007 1322246009332 Chain length determinant protein; Region: Wzz; cl15801 1322246009333 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 1322246009334 Uncharacterized protein conserved in bacteria (DUF2320); Region: DUF2320; pfam10082 1322246009335 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 1322246009336 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 1322246009337 SLBB domain; Region: SLBB; pfam10531 1322246009338 PilZ domain; Region: PilZ; pfam07238 1322246009339 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1322246009340 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1322246009341 active site 1322246009342 phosphorylation site [posttranslational modification] 1322246009343 intermolecular recognition site; other site 1322246009344 dimerization interface [polypeptide binding]; other site 1322246009345 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1322246009346 Walker A motif; other site 1322246009347 ATP binding site [chemical binding]; other site 1322246009348 Walker B motif; other site 1322246009349 arginine finger; other site 1322246009350 PilZ domain; Region: PilZ; pfam07238 1322246009351 FOG: CBS domain [General function prediction only]; Region: COG0517 1322246009352 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 1322246009353 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1322246009354 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1322246009355 metal binding site [ion binding]; metal-binding site 1322246009356 active site 1322246009357 I-site; other site 1322246009358 Predicted integral membrane protein [Function unknown]; Region: COG5652 1322246009359 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 1322246009360 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 1322246009361 ligand binding site [chemical binding]; other site 1322246009362 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1322246009363 dimerization interface [polypeptide binding]; other site 1322246009364 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1322246009365 dimer interface [polypeptide binding]; other site 1322246009366 phosphorylation site [posttranslational modification] 1322246009367 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1322246009368 ATP binding site [chemical binding]; other site 1322246009369 Mg2+ binding site [ion binding]; other site 1322246009370 G-X-G motif; other site 1322246009371 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1322246009372 active site 1322246009373 phosphorylation site [posttranslational modification] 1322246009374 intermolecular recognition site; other site 1322246009375 dimerization interface [polypeptide binding]; other site 1322246009376 Response regulator receiver domain; Region: Response_reg; pfam00072 1322246009377 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1322246009378 active site 1322246009379 phosphorylation site [posttranslational modification] 1322246009380 intermolecular recognition site; other site 1322246009381 dimerization interface [polypeptide binding]; other site 1322246009382 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1322246009383 DNA binding site [nucleotide binding] 1322246009384 active site 1322246009385 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 1322246009386 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1322246009387 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1322246009388 Domain of unknown function (DUF1956); Region: DUF1956; pfam09209 1322246009389 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1322246009390 HlyD family secretion protein; Region: HlyD_3; pfam13437 1322246009391 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1322246009392 trans-homoaconitate synthase; Reviewed; Region: aksA; PRK11858 1322246009393 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 1322246009394 active site 1322246009395 catalytic residues [active] 1322246009396 metal binding site [ion binding]; metal-binding site 1322246009397 nitrogenase reductase; Reviewed; Region: nifH; PRK13235 1322246009398 NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040 1322246009399 Nucleotide-binding sites [chemical binding]; other site 1322246009400 Walker A motif; other site 1322246009401 Switch I region of nucleotide binding site; other site 1322246009402 Fe4S4 binding sites [ion binding]; other site 1322246009403 Switch II region of nucleotide binding site; other site 1322246009404 Nitrogen regulatory protein P-II; Region: P-II; pfam00543 1322246009405 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1322246009406 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 1322246009407 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1322246009408 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 1322246009409 nitrogenase alpha chain; Region: alt_nitrog_alph; TIGR01284 1322246009410 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 1322246009411 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 1322246009412 nitrogenase cofactor biosynthesis protein NifB; Region: nifB; TIGR01290 1322246009413 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1322246009414 FeS/SAM binding site; other site 1322246009415 This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. This...; Region: NifX_NifB; cl00252 1322246009416 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 1322246009417 dimer interface [polypeptide binding]; other site 1322246009418 [2Fe-2S] cluster binding site [ion binding]; other site 1322246009419 nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283 1322246009420 nitrogenase molybdenum-cofactor biosynthesis protein NifE; Provisional; Region: PRK14478 1322246009421 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 1322246009422 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 1322246009423 nitrogenase cofactor biosynthesis protein NifB; Region: nifB; TIGR01290 1322246009424 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1322246009425 FeS/SAM binding site; other site 1322246009426 This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. This...; Region: NifX_NifB; cl00252 1322246009427 thiosulfate reductase PhsA; Provisional; Region: PRK15488 1322246009428 The MopB_Thiosulfate-R-like CD contains thiosulfate-, sulfur-, and polysulfide-reductases, and other related proteins. Thiosulfate reductase catalyzes the cleavage of sulfur-sulfur bonds in thiosulfate. Polysulfide reductase is a membrane-bound enzyme...; Region: MopB_Thiosulfate-R-like; cd02755 1322246009429 putative [Fe4-S4] binding site [ion binding]; other site 1322246009430 putative molybdopterin cofactor binding site [chemical binding]; other site 1322246009431 The MopB_CT_Thiosulfate-R-like CD contains thiosulfate-, sulfur-, and polysulfide-reductases, and other related proteins. Thiosulfate reductase catalyzes the cleavage of sulfur-sulfur bonds in thiosulfate. Polysulfide reductase is a membrane-bound enzyme...; Region: MopB_CT_Thiosulfate-R-like; cd02778 1322246009432 putative molybdopterin cofactor binding site; other site 1322246009433 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 1322246009434 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1322246009435 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 1322246009436 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1322246009437 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1322246009438 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1322246009439 putative active site [active] 1322246009440 heme pocket [chemical binding]; other site 1322246009441 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1322246009442 dimer interface [polypeptide binding]; other site 1322246009443 phosphorylation site [posttranslational modification] 1322246009444 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1322246009445 ATP binding site [chemical binding]; other site 1322246009446 Mg2+ binding site [ion binding]; other site 1322246009447 G-X-G motif; other site 1322246009448 Response regulator receiver domain; Region: Response_reg; pfam00072 1322246009449 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1322246009450 active site 1322246009451 phosphorylation site [posttranslational modification] 1322246009452 intermolecular recognition site; other site 1322246009453 dimerization interface [polypeptide binding]; other site 1322246009454 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1322246009455 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1322246009456 Predicted protein-tyrosine phosphatase [Signal transduction mechanisms]; Region: CDC14; COG2453 1322246009457 active site 1322246009458 catalytic residues [active] 1322246009459 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 1322246009460 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 1322246009461 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 1322246009462 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 1322246009463 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1322246009464 Cysteine-rich domain; Region: CCG; pfam02754 1322246009465 Cysteine-rich domain; Region: CCG; pfam02754 1322246009466 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 1322246009467 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1322246009468 zinc binding site [ion binding]; other site 1322246009469 putative ligand binding site [chemical binding]; other site 1322246009470 PAS domain S-box; Region: sensory_box; TIGR00229 1322246009471 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1322246009472 putative active site [active] 1322246009473 heme pocket [chemical binding]; other site 1322246009474 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1322246009475 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1322246009476 metal binding site [ion binding]; metal-binding site 1322246009477 active site 1322246009478 I-site; other site 1322246009479 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1322246009480 Domain of unknown function (DUF1987); Region: DUF1987; pfam09345 1322246009481 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1322246009482 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1322246009483 Walker A motif; other site 1322246009484 ATP binding site [chemical binding]; other site 1322246009485 Walker B motif; other site 1322246009486 arginine finger; other site 1322246009487 Putative metallopeptidase domain; Region: DUF2201_N; pfam13203 1322246009488 VWA-like domain (DUF2201); Region: DUF2201; pfam09967 1322246009489 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1322246009490 metal binding site 2 [ion binding]; metal-binding site 1322246009491 putative DNA binding helix; other site 1322246009492 metal binding site 1 [ion binding]; metal-binding site 1322246009493 dimer interface [polypeptide binding]; other site 1322246009494 structural Zn2+ binding site [ion binding]; other site 1322246009495 ferric uptake regulator; Provisional; Region: fur; PRK09462 1322246009496 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1322246009497 metal binding site 2 [ion binding]; metal-binding site 1322246009498 putative DNA binding helix; other site 1322246009499 metal binding site 1 [ion binding]; metal-binding site 1322246009500 dimer interface [polypeptide binding]; other site 1322246009501 structural Zn2+ binding site [ion binding]; other site 1322246009502 FeoA domain; Region: FeoA; pfam04023 1322246009503 FeoA domain; Region: FeoA; pfam04023 1322246009504 Ferrous iron transport protein B; Region: FeoB_N; pfam02421 1322246009505 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 1322246009506 G1 box; other site 1322246009507 GTP/Mg2+ binding site [chemical binding]; other site 1322246009508 Switch I region; other site 1322246009509 G2 box; other site 1322246009510 G3 box; other site 1322246009511 Switch II region; other site 1322246009512 G4 box; other site 1322246009513 G5 box; other site 1322246009514 Nucleoside recognition; Region: Gate; pfam07670 1322246009515 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 1322246009516 Domain of unknown function (DUF4198); Region: DUF4198; pfam10670 1322246009517 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 1322246009518 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1322246009519 Zn2+ binding site [ion binding]; other site 1322246009520 Mg2+ binding site [ion binding]; other site 1322246009521 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1322246009522 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 1322246009523 intersubunit interface [polypeptide binding]; other site 1322246009524 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1322246009525 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1322246009526 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1322246009527 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1322246009528 dimer interface [polypeptide binding]; other site 1322246009529 putative PBP binding regions; other site 1322246009530 ABC-ATPase subunit interface; other site 1322246009531 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1322246009532 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 1322246009533 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1322246009534 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1322246009535 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1322246009536 Cation efflux family; Region: Cation_efflux; cl00316 1322246009537 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1322246009538 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1322246009539 dimerization interface [polypeptide binding]; other site 1322246009540 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1322246009541 dimer interface [polypeptide binding]; other site 1322246009542 phosphorylation site [posttranslational modification] 1322246009543 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1322246009544 ATP binding site [chemical binding]; other site 1322246009545 Mg2+ binding site [ion binding]; other site 1322246009546 G-X-G motif; other site 1322246009547 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1322246009548 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 1322246009549 active site 1322246009550 phosphorylation site [posttranslational modification] 1322246009551 intermolecular recognition site; other site 1322246009552 dimerization interface [polypeptide binding]; other site 1322246009553 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1322246009554 DNA binding site [nucleotide binding] 1322246009555 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 1322246009556 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1322246009557 HlyD family secretion protein; Region: HlyD_3; pfam13437 1322246009558 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1322246009559 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1322246009560 metal binding site 2 [ion binding]; metal-binding site 1322246009561 putative DNA binding helix; other site 1322246009562 metal binding site 1 [ion binding]; metal-binding site 1322246009563 dimer interface [polypeptide binding]; other site 1322246009564 structural Zn2+ binding site [ion binding]; other site 1322246009565 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 1322246009566 Metal binding protein ZntC. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: ZntC; cd01018 1322246009567 putative metal binding residues [ion binding]; other site 1322246009568 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1322246009569 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1322246009570 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1322246009571 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1322246009572 putative substrate translocation pore; other site 1322246009573 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1322246009574 HlyD family secretion protein; Region: HlyD; pfam00529 1322246009575 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1322246009576 HlyD family secretion protein; Region: HlyD_3; pfam13437 1322246009577 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1322246009578 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1322246009579 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1322246009580 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1322246009581 Walker A/P-loop; other site 1322246009582 ATP binding site [chemical binding]; other site 1322246009583 Q-loop/lid; other site 1322246009584 ABC transporter signature motif; other site 1322246009585 Walker B; other site 1322246009586 D-loop; other site 1322246009587 H-loop/switch region; other site 1322246009588 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1322246009589 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1322246009590 Walker A/P-loop; other site 1322246009591 ATP binding site [chemical binding]; other site 1322246009592 Q-loop/lid; other site 1322246009593 ABC transporter signature motif; other site 1322246009594 Walker B; other site 1322246009595 D-loop; other site 1322246009596 H-loop/switch region; other site 1322246009597 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1322246009598 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1322246009599 TM-ABC transporter signature motif; other site 1322246009600 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1322246009601 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1322246009602 TM-ABC transporter signature motif; other site 1322246009603 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1322246009604 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_6; cd06340 1322246009605 putative ligand binding site [chemical binding]; other site 1322246009606 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 1322246009607 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1322246009608 inhibitor-cofactor binding pocket; inhibition site 1322246009609 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1322246009610 catalytic residue [active] 1322246009611 PAS domain; Region: PAS; smart00091 1322246009612 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 1322246009613 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1322246009614 putative active site [active] 1322246009615 heme pocket [chemical binding]; other site 1322246009616 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1322246009617 Walker B motif; other site 1322246009618 arginine finger; other site 1322246009619 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 1322246009620 methanogenesis imperfect marker protein 11; Region: methan_mark_11; TIGR03280 1322246009621 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 1322246009622 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1322246009623 motif II; other site 1322246009624 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 1322246009625 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 1322246009626 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 1322246009627 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1322246009628 HlyD family secretion protein; Region: HlyD_3; pfam13437 1322246009629 Protein of unknown function (DUF3347); Region: DUF3347; pfam11827 1322246009630 Protein of unknown function (DUF3347); Region: DUF3347; pfam11827 1322246009631 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 1322246009632 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1322246009633 dimerization interface [polypeptide binding]; other site 1322246009634 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 1322246009635 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1322246009636 FmdE, Molybdenum formylmethanofuran dehydrogenase operon; Region: FmdE; pfam02663 1322246009637 MoeA_like. This domain is similar to a domain found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. There this domain is presumed to bind molybdopterin. The exact function of this subgroup is...; Region: MoeA_like; cd03522 1322246009638 putative MPT binding site; other site 1322246009639 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; cl17549 1322246009640 Syntrophus aciditrophicus Cys-Xaa-Xaa-Xaa repeat radical SAM target protein; Region: Syntroph_Cxxx; TIGR04117 1322246009641 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1322246009642 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1322246009643 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1322246009644 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 1322246009645 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 1322246009646 molybdopterin cofactor binding site; other site 1322246009647 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 1322246009648 Protein involved in formate dehydrogenase formation; Region: FdhE; pfam04216 1322246009649 formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562 1322246009650 FdhD/NarQ family; Region: FdhD-NarQ; pfam02634 1322246009651 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1322246009652 SET domain; Region: SET; pfam00856 1322246009653 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1322246009654 Coenzyme A binding pocket [chemical binding]; other site 1322246009655 nitrogen regulation protein NR(I); Region: ntrC; TIGR01818 1322246009656 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 1322246009657 active site 1322246009658 dimerization interface [polypeptide binding]; other site 1322246009659 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1322246009660 ATP binding site [chemical binding]; other site 1322246009661 Walker B motif; other site 1322246009662 arginine finger; other site 1322246009663 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 1322246009664 sodium/proton antiporter; Reviewed; Region: nhaB; PRK09547 1322246009665 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1322246009666 transmembrane helices; other site 1322246009667 TrkA-C domain; Region: TrkA_C; pfam02080 1322246009668 TrkA-C domain; Region: TrkA_C; pfam02080 1322246009669 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1322246009670 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1322246009671 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 1322246009672 Ligand Binding Site [chemical binding]; other site 1322246009673 Response regulator receiver domain; Region: Response_reg; pfam00072 1322246009674 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1322246009675 active site 1322246009676 phosphorylation site [posttranslational modification] 1322246009677 intermolecular recognition site; other site 1322246009678 dimerization interface [polypeptide binding]; other site 1322246009679 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1322246009680 Walker A motif; other site 1322246009681 ATP binding site [chemical binding]; other site 1322246009682 Walker B motif; other site 1322246009683 arginine finger; other site 1322246009684 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1322246009685 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1322246009686 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1322246009687 active site 1322246009688 phosphorylation site [posttranslational modification] 1322246009689 intermolecular recognition site; other site 1322246009690 dimerization interface [polypeptide binding]; other site 1322246009691 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1322246009692 Walker A motif; other site 1322246009693 ATP binding site [chemical binding]; other site 1322246009694 Walker B motif; other site 1322246009695 arginine finger; other site 1322246009696 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1322246009697 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1322246009698 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1322246009699 dimerization interface [polypeptide binding]; other site 1322246009700 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1322246009701 dimer interface [polypeptide binding]; other site 1322246009702 phosphorylation site [posttranslational modification] 1322246009703 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1322246009704 ATP binding site [chemical binding]; other site 1322246009705 Mg2+ binding site [ion binding]; other site 1322246009706 G-X-G motif; other site 1322246009707 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 1322246009708 homodimer interaction site [polypeptide binding]; other site 1322246009709 cofactor binding site; other site 1322246009710 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1322246009711 active site 1322246009712 catalytic residues [active] 1322246009713 Int/Topo IB signature motif; other site 1322246009714 DNA binding site [nucleotide binding] 1322246009715 molybdenum-pterin binding domain; Region: Mop; TIGR00638 1322246009716 TOBE domain; Region: TOBE; cl01440 1322246009717 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1322246009718 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1322246009719 dimer interface [polypeptide binding]; other site 1322246009720 conserved gate region; other site 1322246009721 putative PBP binding loops; other site 1322246009722 ABC-ATPase subunit interface; other site 1322246009723 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 1322246009724 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1322246009725 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1322246009726 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 1322246009727 Walker A/P-loop; other site 1322246009728 ATP binding site [chemical binding]; other site 1322246009729 Q-loop/lid; other site 1322246009730 ABC transporter signature motif; other site 1322246009731 Walker B; other site 1322246009732 D-loop; other site 1322246009733 H-loop/switch region; other site 1322246009734 Domain of unknown function (DUF389); Region: DUF389; cl00781 1322246009735 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 1322246009736 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 1322246009737 putative [4Fe-4S] binding site [ion binding]; other site 1322246009738 putative molybdopterin cofactor binding site [chemical binding]; other site 1322246009739 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 1322246009740 molybdopterin cofactor binding site; other site 1322246009741 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 1322246009742 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1322246009743 conserved cys residue [active] 1322246009744 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1322246009745 Glycogen synthase; Region: Glycogen_syn; pfam05693 1322246009746 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1322246009747 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 1322246009748 N-terminal catalytic domain of a thermoactive alpha-amylase from Methanococcus jannaschii and similar proteins; glycoside hydrolase family 57 (GH57); Region: GH57N_MJA1_like; cd10795 1322246009749 Glycosyl hydrolase family 57; Region: Glyco_hydro_57; pfam03065 1322246009750 putative active site [active] 1322246009751 catalytic site [active] 1322246009752 glycogen/starch synthase, ADP-glucose type; Region: glgA; TIGR02095 1322246009753 Starch synthase catalytic domain; Region: Glyco_transf_5; pfam08323 1322246009754 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1322246009755 Glycogen debranching enzyme N terminal; Region: GDE_N; pfam12439 1322246009756 glycogen debranching enzyme, archaeal type, putative; Region: gde_arch; TIGR01561 1322246009757 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 1322246009758 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 1322246009759 tetrathionate reductase subunit A; Provisional; Region: PRK14991 1322246009760 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1322246009761 molybdopterin cofactor binding site; other site 1322246009762 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1322246009763 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 1322246009764 molybdopterin cofactor binding site; other site 1322246009765 CO dehydrogenase maturation factor [Cell division and chromosome partitioning]; Region: CooC; COG3640 1322246009766 The accessory protein CooC, which contains a nucleotide-binding domain (P-loop) near the N-terminus, participates in the maturation of the nickel center of carbon monoxide dehydrogenase (CODH). CODH from Rhodospirillum rubrum catalyzes the reversible...; Region: CooC; cd02034 1322246009767 P-loop; other site 1322246009768 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1322246009769 carbon-monoxide dehydrogenase, catalytic subunit; Region: CO_DH_cata; TIGR01702 1322246009770 Carbon monoxide dehydrogenase (CODH) is found in acetogenic and methanogenic organisms and is responsible for the synthesis and breakdown of acetyl-CoA, respectively. CODH has two types of metal clusters, a cubane [Fe4-S4] center (B-cluster) similar to...; Region: CODH; cd01915 1322246009771 ACS interaction site; other site 1322246009772 CODH interaction site; other site 1322246009773 cubane metal cluster (B-cluster) [ion binding]; other site 1322246009774 Ni-Fe-S cluster (C-cluster) [ion binding]; other site 1322246009775 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 1322246009776 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 1322246009777 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 1322246009778 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 1322246009779 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 1322246009780 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 1322246009781 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; pfam00329 1322246009782 hydrogenase 4 subunit H; Validated; Region: PRK08222 1322246009783 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 1322246009784 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 1322246009785 NADH dehydrogenase; Region: NADHdh; cl00469 1322246009786 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1322246009787 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK08376 1322246009788 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1322246009789 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1322246009790 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1322246009791 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1322246009792 ligand binding site [chemical binding]; other site 1322246009793 flexible hinge region; other site 1322246009794 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1322246009795 putative switch regulator; other site 1322246009796 non-specific DNA interactions [nucleotide binding]; other site 1322246009797 DNA binding site [nucleotide binding] 1322246009798 sequence specific DNA binding site [nucleotide binding]; other site 1322246009799 putative cAMP binding site [chemical binding]; other site 1322246009800 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1322246009801 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1322246009802 dimer interface [polypeptide binding]; other site 1322246009803 putative CheW interface [polypeptide binding]; other site 1322246009804 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 1322246009805 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1322246009806 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1322246009807 dimerization interface [polypeptide binding]; other site 1322246009808 putative DNA binding site [nucleotide binding]; other site 1322246009809 putative Zn2+ binding site [ion binding]; other site 1322246009810 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 1322246009811 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 1322246009812 dimer interface [polypeptide binding]; other site 1322246009813 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1322246009814 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1322246009815 active site 1322246009816 phosphorylation site [posttranslational modification] 1322246009817 intermolecular recognition site; other site 1322246009818 dimerization interface [polypeptide binding]; other site 1322246009819 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1322246009820 DNA binding site [nucleotide binding] 1322246009821 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1322246009822 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1322246009823 dimerization interface [polypeptide binding]; other site 1322246009824 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1322246009825 ATP binding site [chemical binding]; other site 1322246009826 Mg2+ binding site [ion binding]; other site 1322246009827 G-X-G motif; other site 1322246009828 ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226 1322246009829 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 1322246009830 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1322246009831 dimer interface [polypeptide binding]; other site 1322246009832 conserved gate region; other site 1322246009833 putative PBP binding loops; other site 1322246009834 ABC-ATPase subunit interface; other site 1322246009835 Domain of unknown function (DUF3333); Region: DUF3333; pfam11812 1322246009836 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 1322246009837 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1322246009838 dimer interface [polypeptide binding]; other site 1322246009839 conserved gate region; other site 1322246009840 putative PBP binding loops; other site 1322246009841 ABC-ATPase subunit interface; other site 1322246009842 inorganic polyphosphate/ATP-NAD kinase; Reviewed; Region: ppnK; PRK04761 1322246009843 ATP-NAD kinase; Region: NAD_kinase; pfam01513 1322246009844 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 1322246009845 dimer interface [polypeptide binding]; other site 1322246009846 Citrate synthase; Region: Citrate_synt; pfam00285 1322246009847 active site 1322246009848 citrylCoA binding site [chemical binding]; other site 1322246009849 NADH binding [chemical binding]; other site 1322246009850 cationic pore residues; other site 1322246009851 oxalacetate/citrate binding site [chemical binding]; other site 1322246009852 coenzyme A binding site [chemical binding]; other site 1322246009853 catalytic triad [active] 1322246009854 Membrane bound FAD containing D-sorbitol dehydrogenase; Region: FAD-SLDH; pfam12318 1322246009855 hydrogenase 2 protein HybA; Provisional; Region: PRK10882 1322246009856 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1322246009857 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1322246009858 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 1322246009859 dimer interface [polypeptide binding]; other site 1322246009860 putative tRNA-binding site [nucleotide binding]; other site 1322246009861 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1322246009862 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1322246009863 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1322246009864 putative active site [active] 1322246009865 heme pocket [chemical binding]; other site 1322246009866 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1322246009867 dimer interface [polypeptide binding]; other site 1322246009868 phosphorylation site [posttranslational modification] 1322246009869 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1322246009870 ATP binding site [chemical binding]; other site 1322246009871 Mg2+ binding site [ion binding]; other site 1322246009872 G-X-G motif; other site 1322246009873 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 1322246009874 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1322246009875 active site 1322246009876 phosphorylation site [posttranslational modification] 1322246009877 intermolecular recognition site; other site 1322246009878 dimerization interface [polypeptide binding]; other site 1322246009879 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1322246009880 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1322246009881 active site 1322246009882 phosphorylation site [posttranslational modification] 1322246009883 intermolecular recognition site; other site 1322246009884 dimerization interface [polypeptide binding]; other site 1322246009885 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1322246009886 Walker A motif; other site 1322246009887 ATP binding site [chemical binding]; other site 1322246009888 Walker B motif; other site 1322246009889 arginine finger; other site 1322246009890 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 1322246009891 4Fe-4S binding domain; Region: Fer4; pfam00037 1322246009892 NADPH-dependent glutamate synthase beta chain and related oxidoreductases [Amino acid transport and metabolism / General function prediction only]; Region: GltD; COG0493 1322246009893 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1322246009894 electron transport complex, RnfABCDGE type, A subunit; Region: rnfA; TIGR01943 1322246009895 electron transport complex RsxE subunit; Provisional; Region: PRK12405 1322246009896 FMN-binding domain; Region: FMN_bind; cl01081 1322246009897 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; cl00779 1322246009898 electron transport complex, RnfABCDGE type, C subunit; Region: rnfC; TIGR01945 1322246009899 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 1322246009900 heme-binding residues [chemical binding]; other site 1322246009901 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 1322246009902 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1322246009903 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1322246009904 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1322246009905 NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691 1322246009906 AIR carboxylase; Region: AIRC; smart01001 1322246009907 ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606 1322246009908 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 1322246009909 Ligand Binding Site [chemical binding]; other site 1322246009910 hypothetical protein; Provisional; Region: PRK04194 1322246009911 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 1322246009912 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1322246009913 active site 1322246009914 catalytic tetrad [active] 1322246009915 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1322246009916 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 1322246009917 FMN binding site [chemical binding]; other site 1322246009918 dimer interface [polypeptide binding]; other site 1322246009919 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 1322246009920 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1322246009921 active site 1322246009922 phosphorylation site [posttranslational modification] 1322246009923 intermolecular recognition site; other site 1322246009924 dimerization interface [polypeptide binding]; other site 1322246009925 LytTr DNA-binding domain; Region: LytTR; pfam04397 1322246009926 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 1322246009927 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 1322246009928 GAF domain; Region: GAF_3; pfam13492 1322246009929 Histidine kinase; Region: His_kinase; pfam06580 1322246009930 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1322246009931 ATP binding site [chemical binding]; other site 1322246009932 Mg2+ binding site [ion binding]; other site 1322246009933 G-X-G motif; other site 1322246009934 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 1322246009935 Carbon starvation protein CstA; Region: CstA; pfam02554 1322246009936 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 1322246009937 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1322246009938 MarR family; Region: MarR; pfam01047 1322246009939 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1322246009940 putative substrate translocation pore; other site 1322246009941 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1322246009942 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 1322246009943 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1322246009944 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1322246009945 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1322246009946 Walker A/P-loop; other site 1322246009947 ATP binding site [chemical binding]; other site 1322246009948 Q-loop/lid; other site 1322246009949 ABC transporter signature motif; other site 1322246009950 Walker B; other site 1322246009951 D-loop; other site 1322246009952 H-loop/switch region; other site 1322246009953 TOBE domain; Region: TOBE_2; pfam08402 1322246009954 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1322246009955 dimer interface [polypeptide binding]; other site 1322246009956 conserved gate region; other site 1322246009957 putative PBP binding loops; other site 1322246009958 ABC-ATPase subunit interface; other site 1322246009959 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1322246009960 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1322246009961 dimer interface [polypeptide binding]; other site 1322246009962 conserved gate region; other site 1322246009963 putative PBP binding loops; other site 1322246009964 ABC-ATPase subunit interface; other site 1322246009965 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 1322246009966 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 1322246009967 active site 1322246009968 catalytic site [active] 1322246009969 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1322246009970 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1322246009971 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1322246009972 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1322246009973 folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499 1322246009974 selenocysteine synthase; Provisional; Region: PRK04311 1322246009975 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 1322246009976 Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921 1322246009977 M18 Peptidase Aminopeptidase I; Region: M18_API; cd05659 1322246009978 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 1322246009979 oligomer interface [polypeptide binding]; other site 1322246009980 putative active site [active] 1322246009981 metal binding site [ion binding]; metal-binding site 1322246009982 selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512 1322246009983 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 1322246009984 G1 box; other site 1322246009985 putative GEF interaction site [polypeptide binding]; other site 1322246009986 GTP/Mg2+ binding site [chemical binding]; other site 1322246009987 Switch I region; other site 1322246009988 G2 box; other site 1322246009989 G3 box; other site 1322246009990 Switch II region; other site 1322246009991 G4 box; other site 1322246009992 G5 box; other site 1322246009993 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 1322246009994 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 1322246009995 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 1322246009996 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 1322246009997 The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cd11524 1322246009998 putative amphipathic alpha helix; other site 1322246009999 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1322246010000 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1322246010001 hinge; other site 1322246010002 active site 1322246010003 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 1322246010004 Rubredoxin; Region: Rubredoxin; pfam00301 1322246010005 iron binding site [ion binding]; other site 1322246010006 Methyltransferase domain; Region: Methyltransf_24; pfam13578 1322246010007 CAAX protease self-immunity; Region: Abi; pfam02517 1322246010008 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 1322246010009 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 1322246010010 intersubunit interface [polypeptide binding]; other site 1322246010011 active site 1322246010012 Zn2+ binding site [ion binding]; other site 1322246010013 Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414 1322246010014 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730 1322246010015 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 1322246010016 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1322246010017 binding surface 1322246010018 TPR repeat; Region: TPR_11; pfam13414 1322246010019 TPR motif; other site 1322246010020 putative molybdopterin biosynthesis protein MoeA/LysR substrate binding-domain-containing protein; Provisional; Region: PRK14498 1322246010021 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1322246010022 dimer interface [polypeptide binding]; other site 1322246010023 putative functional site; other site 1322246010024 putative MPT binding site; other site 1322246010025 PBP superfamily domain; Region: PBP_like; pfam12727 1322246010026 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 1322246010027 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 1322246010028 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 1322246010029 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 1322246010030 Flagellin N-methylase; Region: FliB; cl00497 1322246010031 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1322246010032 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1322246010033 binding surface 1322246010034 TPR motif; other site 1322246010035 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1322246010036 binding surface 1322246010037 TPR motif; other site 1322246010038 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 1322246010039 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1322246010040 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1322246010041 active site 1322246010042 dimer interface [polypeptide binding]; other site 1322246010043 motif 1; other site 1322246010044 motif 2; other site 1322246010045 motif 3; other site 1322246010046 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1322246010047 anticodon binding site; other site 1322246010048 translation initiation factor IF-3; Region: infC; TIGR00168 1322246010049 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1322246010050 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1322246010051 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 1322246010052 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1322246010053 23S rRNA binding site [nucleotide binding]; other site 1322246010054 L21 binding site [polypeptide binding]; other site 1322246010055 L13 binding site [polypeptide binding]; other site 1322246010056 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1322246010057 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1322246010058 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1322246010059 dimer interface [polypeptide binding]; other site 1322246010060 motif 1; other site 1322246010061 active site 1322246010062 motif 2; other site 1322246010063 motif 3; other site 1322246010064 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1322246010065 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1322246010066 putative tRNA-binding site [nucleotide binding]; other site 1322246010067 B3/4 domain; Region: B3_4; pfam03483 1322246010068 tRNA synthetase B5 domain; Region: B5; pfam03484 1322246010069 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1322246010070 dimer interface [polypeptide binding]; other site 1322246010071 motif 1; other site 1322246010072 motif 3; other site 1322246010073 motif 2; other site 1322246010074 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896 1322246010075 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1322246010076 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1322246010077 DNA binding residues [nucleotide binding] 1322246010078 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 1322246010079 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 1322246010080 flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496 1322246010081 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 1322246010082 Walker A motif/ATP binding site; other site 1322246010083 Walker B motif; other site 1322246010084 Flagellar assembly protein FliH; Region: FliH; pfam02108 1322246010085 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 1322246010086 MgtE intracellular N domain; Region: MgtE_N; cl15244 1322246010087 FliG C-terminal domain; Region: FliG_C; pfam01706 1322246010088 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 1322246010089 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 1322246010090 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 1322246010091 Flagellar hook-basal body complex protein FliE; Region: FliE; pfam02049 1322246010092 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 1322246010093 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1322246010094 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1322246010095 flagellar basal body rod protein FlgB; Provisional; Region: flgB; PRK12621 1322246010096 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 1322246010097 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1322246010098 binding surface 1322246010099 TPR repeat; Region: TPR_11; pfam13414 1322246010100 TPR motif; other site 1322246010101 TPR repeat; Region: TPR_11; pfam13414 1322246010102 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1322246010103 binding surface 1322246010104 TPR motif; other site 1322246010105 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1322246010106 purine monophosphate binding site [chemical binding]; other site 1322246010107 dimer interface [polypeptide binding]; other site 1322246010108 putative catalytic residues [active] 1322246010109 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 1322246010110 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1322246010111 HflX GTPase family; Region: HflX; cd01878 1322246010112 G1 box; other site 1322246010113 GTP/Mg2+ binding site [chemical binding]; other site 1322246010114 Switch I region; other site 1322246010115 G2 box; other site 1322246010116 G3 box; other site 1322246010117 Switch II region; other site 1322246010118 G4 box; other site 1322246010119 G5 box; other site 1322246010120 Sulfotransferase family; Region: Sulfotransfer_2; pfam03567 1322246010121 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1322246010122 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 1322246010123 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 1322246010124 RNB domain; Region: RNB; pfam00773 1322246010125 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 1322246010126 Uncharacterized conserved protein [Function unknown]; Region: COG4095 1322246010127 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 1322246010128 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 1322246010129 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1322246010130 dimerization interface [polypeptide binding]; other site 1322246010131 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1322246010132 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1322246010133 dimer interface [polypeptide binding]; other site 1322246010134 putative CheW interface [polypeptide binding]; other site 1322246010135 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 1322246010136 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1322246010137 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1322246010138 dimer interface [polypeptide binding]; other site 1322246010139 putative CheW interface [polypeptide binding]; other site 1322246010140 Hemerythrin; Region: Hemerythrin; cd12107 1322246010141 Fe binding site [ion binding]; other site 1322246010142 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1322246010143 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1322246010144 GDP-binding site [chemical binding]; other site 1322246010145 ACT binding site; other site 1322246010146 IMP binding site; other site 1322246010147 DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177 1322246010148 DNA polymerase III subunit delta'; Validated; Region: PRK08769 1322246010149 DNA polymerase III subunit delta'; Validated; Region: PRK08485 1322246010150 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1322246010151 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1322246010152 Coenzyme A binding pocket [chemical binding]; other site 1322246010153 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1322246010154 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1322246010155 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1322246010156 adenylate cyclase; Provisional; Region: cyaA; PRK09450 1322246010157 Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633 1322246010158 Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295 1322246010159 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1322246010160 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1322246010161 active site 1322246010162 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1322246010163 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 1322246010164 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 1322246010165 4Fe-4S binding domain; Region: Fer4; cl02805 1322246010166 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 1322246010167 Ligand Binding Site [chemical binding]; other site 1322246010168 Electron transfer flavoprotein domain; Region: ETF; pfam01012 1322246010169 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 1322246010170 Electron transfer flavoprotein domain; Region: ETF; smart00893 1322246010171 PAS domain; Region: PAS_9; pfam13426 1322246010172 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1322246010173 putative active site [active] 1322246010174 heme pocket [chemical binding]; other site 1322246010175 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1322246010176 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1322246010177 dimer interface [polypeptide binding]; other site 1322246010178 phosphorylation site [posttranslational modification] 1322246010179 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1322246010180 ATP binding site [chemical binding]; other site 1322246010181 Mg2+ binding site [ion binding]; other site 1322246010182 G-X-G motif; other site 1322246010183 Response regulator receiver domain; Region: Response_reg; pfam00072 1322246010184 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1322246010185 active site 1322246010186 phosphorylation site [posttranslational modification] 1322246010187 intermolecular recognition site; other site 1322246010188 dimerization interface [polypeptide binding]; other site 1322246010189 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1322246010190 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1322246010191 active site 1322246010192 phosphorylation site [posttranslational modification] 1322246010193 intermolecular recognition site; other site 1322246010194 dimerization interface [polypeptide binding]; other site 1322246010195 DsrE/DsrF-like family; Region: DrsE; pfam02635 1322246010196 OsmC-like protein; Region: OsmC; pfam02566 1322246010197 Isochorismatase family; Region: Isochorismatase; pfam00857 1322246010198 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 1322246010199 catalytic triad [active] 1322246010200 conserved cis-peptide bond; other site 1322246010201 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 1322246010202 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1322246010203 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 1322246010204 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 1322246010205 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1322246010206 G1 box; other site 1322246010207 putative GEF interaction site [polypeptide binding]; other site 1322246010208 GTP/Mg2+ binding site [chemical binding]; other site 1322246010209 Switch I region; other site 1322246010210 G2 box; other site 1322246010211 G3 box; other site 1322246010212 Switch II region; other site 1322246010213 G4 box; other site 1322246010214 G5 box; other site 1322246010215 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1322246010216 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1322246010217 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 1322246010218 Aspartase; Region: Aspartase; cd01357 1322246010219 active sites [active] 1322246010220 tetramer interface [polypeptide binding]; other site 1322246010221 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1322246010222 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1322246010223 substrate binding pocket [chemical binding]; other site 1322246010224 membrane-bound complex binding site; other site 1322246010225 hinge residues; other site 1322246010226 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 1322246010227 rare lipoprotein A; Region: rlpA; TIGR00413 1322246010228 Sporulation related domain; Region: SPOR; pfam05036 1322246010229 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1322246010230 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1322246010231 dimer interface [polypeptide binding]; other site 1322246010232 phosphorylation site [posttranslational modification] 1322246010233 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1322246010234 ATP binding site [chemical binding]; other site 1322246010235 Mg2+ binding site [ion binding]; other site 1322246010236 G-X-G motif; other site 1322246010237 Response regulator receiver domain; Region: Response_reg; pfam00072 1322246010238 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1322246010239 active site 1322246010240 phosphorylation site [posttranslational modification] 1322246010241 intermolecular recognition site; other site 1322246010242 dimerization interface [polypeptide binding]; other site 1322246010243 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1322246010244 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1322246010245 active site 1322246010246 phosphorylation site [posttranslational modification] 1322246010247 intermolecular recognition site; other site 1322246010248 dimerization interface [polypeptide binding]; other site 1322246010249 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1322246010250 Walker A motif; other site 1322246010251 ATP binding site [chemical binding]; other site 1322246010252 Walker B motif; other site 1322246010253 arginine finger; other site 1322246010254 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1322246010255 IHF dimer interface [polypeptide binding]; other site 1322246010256 IHF - DNA interface [nucleotide binding]; other site 1322246010257 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 1322246010258 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 1322246010259 dimer interface [polypeptide binding]; other site 1322246010260 PYR/PP interface [polypeptide binding]; other site 1322246010261 TPP binding site [chemical binding]; other site 1322246010262 substrate binding site [chemical binding]; other site 1322246010263 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 1322246010264 Domain of unknown function; Region: EKR; smart00890 1322246010265 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1322246010266 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 1322246010267 TPP-binding site [chemical binding]; other site 1322246010268 dimer interface [polypeptide binding]; other site 1322246010269 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 1322246010270 L-lactate permease; Region: Lactate_perm; cl00701 1322246010271 FAD binding domain; Region: FAD_binding_4; pfam01565 1322246010272 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 1322246010273 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1322246010274 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1322246010275 Cysteine-rich domain; Region: CCG; pfam02754 1322246010276 Cysteine-rich domain; Region: CCG; pfam02754 1322246010277 phosphate acetyltransferase; Reviewed; Region: PRK05632 1322246010278 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 1322246010279 DRTGG domain; Region: DRTGG; pfam07085 1322246010280 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 1322246010281 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 1322246010282 propionate/acetate kinase; Provisional; Region: PRK12379 1322246010283 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 1322246010284 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 1322246010285 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 1322246010286 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1322246010287 Cysteine-rich domain; Region: CCG; pfam02754 1322246010288 Cysteine-rich domain; Region: CCG; pfam02754 1322246010289 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1322246010290 PAS domain; Region: PAS_9; pfam13426 1322246010291 putative active site [active] 1322246010292 heme pocket [chemical binding]; other site 1322246010293 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1322246010294 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1322246010295 dimer interface [polypeptide binding]; other site 1322246010296 putative CheW interface [polypeptide binding]; other site 1322246010297 Stress responsive A/B Barrel Domain; Region: Dabb; pfam07876 1322246010298 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 1322246010299 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1322246010300 active site 1322246010301 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1322246010302 phosphorylation site [posttranslational modification] 1322246010303 intermolecular recognition site; other site 1322246010304 dimerization interface [polypeptide binding]; other site 1322246010305 Domain of unknown function (DUF3369); Region: DUF3369; pfam11849 1322246010306 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1322246010307 dimer interface [polypeptide binding]; other site 1322246010308 phosphorylation site [posttranslational modification] 1322246010309 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1322246010310 ATP binding site [chemical binding]; other site 1322246010311 Mg2+ binding site [ion binding]; other site 1322246010312 G-X-G motif; other site 1322246010313 sodium/proton antiporter; Reviewed; Region: nhaB; PRK09547 1322246010314 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1322246010315 putative trimer interface [polypeptide binding]; other site 1322246010316 putative CoA binding site [chemical binding]; other site 1322246010317 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1322246010318 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 1322246010319 transmembrane helices; other site 1322246010320 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 1322246010321 Dinitrogenase iron-molybdenum cofactor; Region: Nitro_FeMo-Co; pfam02579 1322246010322 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1322246010323 PAS domain; Region: PAS_9; pfam13426 1322246010324 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 1322246010325 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1322246010326 Walker A motif; other site 1322246010327 ATP binding site [chemical binding]; other site 1322246010328 Walker B motif; other site 1322246010329 arginine finger; other site 1322246010330 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1322246010331 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 1322246010332 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 1322246010333 lipoyl synthase; Provisional; Region: PRK05481 1322246010334 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1322246010335 FeS/SAM binding site; other site 1322246010336 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1322246010337 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 1322246010338 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1322246010339 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 1322246010340 putative NAD(P) binding site [chemical binding]; other site 1322246010341 catalytic Zn binding site [ion binding]; other site 1322246010342 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 1322246010343 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1322246010344 putative active site [active] 1322246010345 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1322246010346 Walker A motif; other site 1322246010347 ATP binding site [chemical binding]; other site 1322246010348 Walker B motif; other site 1322246010349 arginine finger; other site 1322246010350 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1322246010351 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1322246010352 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1322246010353 E3 interaction surface; other site 1322246010354 lipoyl attachment site [posttranslational modification]; other site 1322246010355 e3 binding domain; Region: E3_binding; pfam02817 1322246010356 e3 binding domain; Region: E3_binding; pfam02817 1322246010357 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1322246010358 Conserved hypothetical protein (Lin0512_fam); Region: Lin0512_fam; cl09807 1322246010359 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 1322246010360 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1322246010361 tetramer interface [polypeptide binding]; other site 1322246010362 TPP-binding site [chemical binding]; other site 1322246010363 heterodimer interface [polypeptide binding]; other site 1322246010364 phosphorylation loop region [posttranslational modification] 1322246010365 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1322246010366 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1322246010367 alpha subunit interface [polypeptide binding]; other site 1322246010368 TPP binding site [chemical binding]; other site 1322246010369 heterodimer interface [polypeptide binding]; other site 1322246010370 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1322246010371 Predicted inorganic polyphosphate/ATP-NAD kinase [General function prediction only]; Region: COG3199 1322246010372 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1322246010373 CoenzymeA binding site [chemical binding]; other site 1322246010374 subunit interaction site [polypeptide binding]; other site 1322246010375 PHB binding site; other site 1322246010376 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1322246010377 ParA-like protein; Provisional; Region: PHA02518 1322246010378 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1322246010379 P-loop; other site 1322246010380 Magnesium ion binding site [ion binding]; other site 1322246010381 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 1322246010382 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 1322246010383 putative trimer interface [polypeptide binding]; other site 1322246010384 putative CoA binding site [chemical binding]; other site 1322246010385 Predicted permeases [General function prediction only]; Region: COG0679 1322246010386 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 1322246010387 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1322246010388 active site 1322246010389 (T/H)XGH motif; other site 1322246010390 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1322246010391 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1322246010392 putative active site [active] 1322246010393 Domain of unknown function DUF21; Region: DUF21; pfam01595 1322246010394 FOG: CBS domain [General function prediction only]; Region: COG0517 1322246010395 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1322246010396 CcmE; Region: CcmE; cl00994 1322246010397 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138 1322246010398 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1322246010399 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 1322246010400 Walker A/P-loop; other site 1322246010401 ATP binding site [chemical binding]; other site 1322246010402 Q-loop/lid; other site 1322246010403 ABC transporter signature motif; other site 1322246010404 Walker B; other site 1322246010405 D-loop; other site 1322246010406 H-loop/switch region; other site 1322246010407 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 1322246010408 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1322246010409 binding surface 1322246010410 TPR motif; other site 1322246010411 TPR repeat; Region: TPR_11; pfam13414 1322246010412 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1322246010413 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 1322246010414 dimerization interface [polypeptide binding]; other site 1322246010415 ligand binding site [chemical binding]; other site 1322246010416 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1322246010417 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1322246010418 TM-ABC transporter signature motif; other site 1322246010419 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1322246010420 TM-ABC transporter signature motif; other site 1322246010421 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1322246010422 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1322246010423 Walker A/P-loop; other site 1322246010424 ATP binding site [chemical binding]; other site 1322246010425 Q-loop/lid; other site 1322246010426 ABC transporter signature motif; other site 1322246010427 Walker B; other site 1322246010428 D-loop; other site 1322246010429 H-loop/switch region; other site 1322246010430 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1322246010431 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1322246010432 Walker A/P-loop; other site 1322246010433 ATP binding site [chemical binding]; other site 1322246010434 Q-loop/lid; other site 1322246010435 ABC transporter signature motif; other site 1322246010436 Walker B; other site 1322246010437 D-loop; other site 1322246010438 H-loop/switch region; other site 1322246010439 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 1322246010440 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1322246010441 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 1322246010442 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1322246010443 active site 1322246010444 GMP synthase; Reviewed; Region: guaA; PRK00074 1322246010445 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1322246010446 AMP/PPi binding site [chemical binding]; other site 1322246010447 candidate oxyanion hole; other site 1322246010448 catalytic triad [active] 1322246010449 potential glutamine specificity residues [chemical binding]; other site 1322246010450 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1322246010451 ATP Binding subdomain [chemical binding]; other site 1322246010452 Ligand Binding sites [chemical binding]; other site 1322246010453 Dimerization subdomain; other site 1322246010454 Sec-independent protein secretion pathway components [Intracellular trafficking and secretion]; Region: TatA; COG1826 1322246010455 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 1322246010456 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 1322246010457 putative active site pocket [active] 1322246010458 4-fold oligomerization interface [polypeptide binding]; other site 1322246010459 metal binding residues [ion binding]; metal-binding site 1322246010460 3-fold/trimer interface [polypeptide binding]; other site 1322246010461 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 1322246010462 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 1322246010463 catalytic residues [active] 1322246010464 mechanosensitive channel MscS; Provisional; Region: PRK10334 1322246010465 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1322246010466 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 1322246010467 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1322246010468 putative metal binding site; other site 1322246010469 uracil-xanthine permease; Region: ncs2; TIGR00801 1322246010470 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1322246010471 active site 1322246010472 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1322246010473 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1322246010474 RNA binding surface [nucleotide binding]; other site 1322246010475 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1322246010476 active site 1322246010477 Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249 1322246010478 GTP/Mg2+ binding site [chemical binding]; other site 1322246010479 G5 box; other site 1322246010480 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 1322246010481 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1322246010482 CoA-binding site [chemical binding]; other site 1322246010483 ATP-binding [chemical binding]; other site 1322246010484 G1 box; other site 1322246010485 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 1322246010486 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1322246010487 active site 1322246010488 nucleotide binding site [chemical binding]; other site 1322246010489 HIGH motif; other site 1322246010490 KMSKS motif; other site 1322246010491 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: PhosphMutase; cl17294 1322246010492 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 1322246010493 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432 1322246010494 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 1322246010495 active site 1322246010496 PHP-associated; Region: PHP_C; pfam13263 1322246010497 chaperone protein DnaJ; Region: DnaJ_bact; TIGR02349 1322246010498 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1322246010499 HSP70 interaction site [polypeptide binding]; other site 1322246010500 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1322246010501 substrate binding site [polypeptide binding]; other site 1322246010502 dimer interface [polypeptide binding]; other site 1322246010503 MerR HTH family regulatory protein; Region: MerR_2; pfam13591 1322246010504 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 1322246010505 Clp amino terminal domain; Region: Clp_N; pfam02861 1322246010506 Clp amino terminal domain; Region: Clp_N; pfam02861 1322246010507 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1322246010508 Walker A motif; other site 1322246010509 ATP binding site [chemical binding]; other site 1322246010510 Walker B motif; other site 1322246010511 arginine finger; other site 1322246010512 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1322246010513 Walker A motif; other site 1322246010514 ATP binding site [chemical binding]; other site 1322246010515 Walker B motif; other site 1322246010516 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1322246010517 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1322246010518 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1322246010519 putative substrate translocation pore; other site 1322246010520 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1322246010521 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1322246010522 substrate binding pocket [chemical binding]; other site 1322246010523 membrane-bound complex binding site; other site 1322246010524 hinge residues; other site 1322246010525 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429 1322246010526 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 1322246010527 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 1322246010528 GrpE; Region: GrpE; pfam01025 1322246010529 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1322246010530 dimer interface [polypeptide binding]; other site 1322246010531 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1322246010532 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1322246010533 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 1322246010534 nucleotide binding site [chemical binding]; other site 1322246010535 NEF interaction site [polypeptide binding]; other site 1322246010536 SBD interface [polypeptide binding]; other site 1322246010537 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1322246010538 putative CheW interface [polypeptide binding]; other site 1322246010539 dimer interface [polypeptide binding]; other site 1322246010540 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1322246010541 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 1322246010542 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1322246010543 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 1322246010544 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 1322246010545 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1322246010546 Ligand Binding Site [chemical binding]; other site 1322246010547 TPR repeat; Region: TPR_11; pfam13414 1322246010548 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1322246010549 MiaB-like tRNA modifying enzyme; Region: MiaB-like-C; TIGR01579 1322246010550 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1322246010551 FeS/SAM binding site; other site 1322246010552 Domain of unknown function (DUF4416); Region: DUF4416; pfam14385 1322246010553 hypothetical protein; Provisional; Region: PRK11820 1322246010554 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 1322246010555 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 1322246010556 hypothetical protein; Provisional; Region: PRK04323 1322246010557 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1322246010558 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1322246010559 catalytic site [active] 1322246010560 G-X2-G-X-G-K; other site 1322246010561 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1322246010562 active site 1322246010563 dimer interface [polypeptide binding]; other site 1322246010564 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1322246010565 binding surface 1322246010566 TPR motif; other site 1322246010567 TPR repeat; Region: TPR_11; pfam13414 1322246010568 HDOD domain; Region: HDOD; pfam08668 1322246010569 HD domain; Region: HD; pfam01966 1322246010570 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 1322246010571 DHH family; Region: DHH; pfam01368 1322246010572 DHHA1 domain; Region: DHHA1; pfam02272 1322246010573 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 1322246010574 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1322246010575 FeS/SAM binding site; other site 1322246010576 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 1322246010577 Mitochondrial small ribosomal subunit Rsm22; Region: Rsm22; cl17847 1322246010578 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1322246010579 Uncharacterized metal-binding protein [General function prediction only]; Region: COG3894 1322246010580 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 1322246010581 Cobalt chelatase (CbiK); Region: CbiK; pfam06180 1322246010582 active site 1322246010583 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 1322246010584 active site 1322246010585 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 1322246010586 active site 1322246010587 SAM binding site [chemical binding]; other site 1322246010588 homodimer interface [polypeptide binding]; other site 1322246010589 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1322246010590 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1322246010591 intersubunit interface [polypeptide binding]; other site 1322246010592 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1322246010593 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1322246010594 Walker A/P-loop; other site 1322246010595 ATP binding site [chemical binding]; other site 1322246010596 Q-loop/lid; other site 1322246010597 ABC transporter signature motif; other site 1322246010598 Walker B; other site 1322246010599 D-loop; other site 1322246010600 H-loop/switch region; other site 1322246010601 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1322246010602 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1322246010603 ABC-ATPase subunit interface; other site 1322246010604 dimer interface [polypeptide binding]; other site 1322246010605 putative PBP binding regions; other site 1322246010606 Cobalt chelatase (CbiK); Region: CbiK; pfam06180 1322246010607 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 1322246010608 active site 1322246010609 Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), C-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_C; cd03413 1322246010610 active site 1322246010611 N-terminal domain interface [polypeptide binding]; other site 1322246010612 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 1322246010613 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 1322246010614 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1322246010615 ATP binding site [chemical binding]; other site 1322246010616 Mg2+ binding site [ion binding]; other site 1322246010617 G-X-G motif; other site 1322246010618 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 1322246010619 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1322246010620 putative binding surface; other site 1322246010621 active site 1322246010622 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1322246010623 Response regulator receiver domain; Region: Response_reg; pfam00072 1322246010624 active site 1322246010625 phosphorylation site [posttranslational modification] 1322246010626 intermolecular recognition site; other site 1322246010627 dimerization interface [polypeptide binding]; other site 1322246010628 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1322246010629 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 1322246010630 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1322246010631 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1322246010632 active site 1322246010633 phosphorylation site [posttranslational modification] 1322246010634 intermolecular recognition site; other site 1322246010635 dimerization interface [polypeptide binding]; other site 1322246010636 Response regulator receiver domain; Region: Response_reg; pfam00072 1322246010637 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1322246010638 active site 1322246010639 phosphorylation site [posttranslational modification] 1322246010640 intermolecular recognition site; other site 1322246010641 dimerization interface [polypeptide binding]; other site 1322246010642 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1322246010643 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1322246010644 dimer interface [polypeptide binding]; other site 1322246010645 phosphorylation site [posttranslational modification] 1322246010646 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1322246010647 ATP binding site [chemical binding]; other site 1322246010648 Mg2+ binding site [ion binding]; other site 1322246010649 G-X-G motif; other site 1322246010650 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 1322246010651 nudix motif; other site 1322246010652 4-hydroxythreonine-4-phosphate dehydrogenase; Region: pdxA; TIGR00557 1322246010653 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 1322246010654 D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942 1322246010655 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1322246010656 active site 1322246010657 motif I; other site 1322246010658 motif II; other site 1322246010659 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1322246010660 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1322246010661 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1322246010662 TPR motif; other site 1322246010663 binding surface 1322246010664 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1322246010665 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 1322246010666 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1322246010667 catalytic site [active] 1322246010668 subunit interface [polypeptide binding]; other site 1322246010669 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 1322246010670 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 1322246010671 Ligand binding site; other site 1322246010672 oligomer interface; other site 1322246010673 3-deoxy-D-manno-octulosonic-acid transferase [Cell envelope biogenesis, outer membrane]; Region: KdtA; COG1519 1322246010674 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 1322246010675 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 1322246010676 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1322246010677 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1322246010678 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 1322246010679 This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851 1322246010680 MinD superfamily P-loop ATPase containing an inserted ferredoxin domain [Energy production and conversion]; Region: COG1149 1322246010681 This protein family's function is unkown. It contains nucleotide binding site. It uses NTP as energy source to transfer electron or ion; Region: Fer4_NifH_child; cd03110 1322246010682 P loop nucleotide binding; other site 1322246010683 switch II; other site 1322246010684 MinD superfamily P-loop ATPase containing an inserted ferredoxin domain [Energy production and conversion]; Region: COG1149 1322246010685 This protein family's function is unkown. It contains nucleotide binding site. It uses NTP as energy source to transfer electron or ion; Region: Fer4_NifH_child; cd03110 1322246010686 P loop nucleotide binding; other site 1322246010687 switch II; other site 1322246010688 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1322246010689 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1322246010690 DNA binding residues [nucleotide binding] 1322246010691 This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. This...; Region: NifX_NifB; cd00562 1322246010692 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 1322246010693 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 1322246010694 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 1322246010695 dimerization interface [polypeptide binding]; other site 1322246010696 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 1322246010697 ATP binding site [chemical binding]; other site 1322246010698 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 1322246010699 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1322246010700 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1322246010701 active site 1322246010702 phosphorylation site [posttranslational modification] 1322246010703 intermolecular recognition site; other site 1322246010704 dimerization interface [polypeptide binding]; other site 1322246010705 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1322246010706 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 1322246010707 FMN binding site [chemical binding]; other site 1322246010708 active site 1322246010709 catalytic residues [active] 1322246010710 substrate binding site [chemical binding]; other site 1322246010711 elongation factor Tu; Reviewed; Region: PRK00049 1322246010712 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1322246010713 G1 box; other site 1322246010714 GEF interaction site [polypeptide binding]; other site 1322246010715 GTP/Mg2+ binding site [chemical binding]; other site 1322246010716 Switch I region; other site 1322246010717 G2 box; other site 1322246010718 G3 box; other site 1322246010719 Switch II region; other site 1322246010720 G4 box; other site 1322246010721 G5 box; other site 1322246010722 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1322246010723 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1322246010724 Antibiotic Binding Site [chemical binding]; other site 1322246010725 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 1322246010726 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1322246010727 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1322246010728 putative homodimer interface [polypeptide binding]; other site 1322246010729 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1322246010730 heterodimer interface [polypeptide binding]; other site 1322246010731 homodimer interface [polypeptide binding]; other site 1322246010732 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1322246010733 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1322246010734 23S rRNA interface [nucleotide binding]; other site 1322246010735 L7/L12 interface [polypeptide binding]; other site 1322246010736 putative thiostrepton binding site; other site 1322246010737 L25 interface [polypeptide binding]; other site 1322246010738 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1322246010739 mRNA/rRNA interface [nucleotide binding]; other site 1322246010740 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1322246010741 23S rRNA interface [nucleotide binding]; other site 1322246010742 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1322246010743 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1322246010744 core dimer interface [polypeptide binding]; other site 1322246010745 peripheral dimer interface [polypeptide binding]; other site 1322246010746 L10 interface [polypeptide binding]; other site 1322246010747 L11 interface [polypeptide binding]; other site 1322246010748 putative EF-Tu interaction site [polypeptide binding]; other site 1322246010749 putative EF-G interaction site [polypeptide binding]; other site 1322246010750 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 1322246010751 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1322246010752 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 1322246010753 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 1322246010754 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1322246010755 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 1322246010756 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1322246010757 RPB3 interaction site [polypeptide binding]; other site 1322246010758 RPB1 interaction site [polypeptide binding]; other site 1322246010759 RPB11 interaction site [polypeptide binding]; other site 1322246010760 RPB10 interaction site [polypeptide binding]; other site 1322246010761 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 1322246010762 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1322246010763 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1322246010764 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1322246010765 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1322246010766 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 1322246010767 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 1322246010768 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 1322246010769 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 1322246010770 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1322246010771 DNA binding site [nucleotide binding] 1322246010772 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1322246010773 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1322246010774 S17 interaction site [polypeptide binding]; other site 1322246010775 S8 interaction site; other site 1322246010776 16S rRNA interaction site [nucleotide binding]; other site 1322246010777 streptomycin interaction site [chemical binding]; other site 1322246010778 23S rRNA interaction site [nucleotide binding]; other site 1322246010779 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1322246010780 30S ribosomal protein S7; Validated; Region: PRK05302 1322246010781 elongation factor G; Reviewed; Region: PRK00007 1322246010782 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1322246010783 G1 box; other site 1322246010784 putative GEF interaction site [polypeptide binding]; other site 1322246010785 GTP/Mg2+ binding site [chemical binding]; other site 1322246010786 Switch I region; other site 1322246010787 G2 box; other site 1322246010788 G3 box; other site 1322246010789 Switch II region; other site 1322246010790 G4 box; other site 1322246010791 G5 box; other site 1322246010792 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1322246010793 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1322246010794 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1322246010795 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1322246010796 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 1322246010797 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 1322246010798 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1322246010799 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1322246010800 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1322246010801 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1322246010802 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 1322246010803 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1322246010804 putative translocon binding site; other site 1322246010805 protein-rRNA interface [nucleotide binding]; other site 1322246010806 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1322246010807 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1322246010808 G-X-X-G motif; other site 1322246010809 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1322246010810 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1322246010811 23S rRNA interface [nucleotide binding]; other site 1322246010812 5S rRNA interface [nucleotide binding]; other site 1322246010813 putative antibiotic binding site [chemical binding]; other site 1322246010814 L25 interface [polypeptide binding]; other site 1322246010815 L27 interface [polypeptide binding]; other site 1322246010816 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1322246010817 23S rRNA interface [nucleotide binding]; other site 1322246010818 putative translocon interaction site; other site 1322246010819 signal recognition particle (SRP54) interaction site; other site 1322246010820 L23 interface [polypeptide binding]; other site 1322246010821 trigger factor interaction site; other site 1322246010822 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1322246010823 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 1322246010824 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1322246010825 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1322246010826 RNA binding site [nucleotide binding]; other site 1322246010827 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1322246010828 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1322246010829 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1322246010830 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 1322246010831 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 1322246010832 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1322246010833 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1322246010834 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1322246010835 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1322246010836 5S rRNA interface [nucleotide binding]; other site 1322246010837 L27 interface [polypeptide binding]; other site 1322246010838 23S rRNA interface [nucleotide binding]; other site 1322246010839 L5 interface [polypeptide binding]; other site 1322246010840 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 1322246010841 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1322246010842 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1322246010843 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 1322246010844 23S rRNA binding site [nucleotide binding]; other site 1322246010845 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1322246010846 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1322246010847 SecY translocase; Region: SecY; pfam00344 1322246010848 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1322246010849 active site 1322246010850 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 1322246010851 30S ribosomal protein S13; Region: bact_S13; TIGR03631 1322246010852 30S ribosomal protein S11; Validated; Region: PRK05309 1322246010853 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1322246010854 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1322246010855 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1322246010856 RNA binding surface [nucleotide binding]; other site 1322246010857 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1322246010858 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1322246010859 alphaNTD - beta interaction site [polypeptide binding]; other site 1322246010860 alphaNTD homodimer interface [polypeptide binding]; other site 1322246010861 alphaNTD - beta' interaction site [polypeptide binding]; other site 1322246010862 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1322246010863 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 1322246010864 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1322246010865 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1322246010866 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 1322246010867 putative dimerization interface [polypeptide binding]; other site 1322246010868 Menaquinone biosynthesis; Region: VitK2_biosynth; pfam02621 1322246010869 menaquinone biosynthesis protein, SCO4550 family; Region: mena_SCO4550; TIGR03699 1322246010870 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 1322246010871 FeS/SAM binding site; other site 1322246010872 putative menaquinone biosynthesis protein, SCO4494 family; Region: mena_SCO4494; TIGR03700 1322246010873 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1322246010874 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1322246010875 Menaquinone biosynthesis; Region: VitK2_biosynth; cl17475 1322246010876 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1322246010877 EamA-like transporter family; Region: EamA; pfam00892 1322246010878 EamA-like transporter family; Region: EamA; pfam00892 1322246010879 hypothetical protein; Provisional; Region: PRK05255 1322246010880 Protein of unknown function (DUF330); Region: DUF330; pfam03886 1322246010881 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 1322246010882 mce related protein; Region: MCE; pfam02470 1322246010883 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 1322246010884 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1322246010885 Walker A/P-loop; other site 1322246010886 ATP binding site [chemical binding]; other site 1322246010887 Q-loop/lid; other site 1322246010888 ABC transporter signature motif; other site 1322246010889 Walker B; other site 1322246010890 D-loop; other site 1322246010891 H-loop/switch region; other site 1322246010892 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1322246010893 anti sigma factor interaction site; other site 1322246010894 regulatory phosphorylation site [posttranslational modification]; other site 1322246010895 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1322246010896 Permease; Region: Permease; pfam02405 1322246010897 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1322246010898 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1322246010899 putative DNA binding site [nucleotide binding]; other site 1322246010900 putative Zn2+ binding site [ion binding]; other site 1322246010901 AsnC family; Region: AsnC_trans_reg; pfam01037 1322246010902 Proline dehydrogenase; Region: Pro_dh; cl03282 1322246010903 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 1322246010904 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 1322246010905 Glutamate binding site [chemical binding]; other site 1322246010906 homodimer interface [polypeptide binding]; other site 1322246010907 NAD binding site [chemical binding]; other site 1322246010908 catalytic residues [active] 1322246010909 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1322246010910 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1322246010911 Coenzyme A binding pocket [chemical binding]; other site 1322246010912 ABC transporter ATPase component; Reviewed; Region: PRK11147 1322246010913 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1322246010914 Walker A/P-loop; other site 1322246010915 ATP binding site [chemical binding]; other site 1322246010916 Q-loop/lid; other site 1322246010917 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1322246010918 ABC transporter signature motif; other site 1322246010919 Walker B; other site 1322246010920 ABC transporter; Region: ABC_tran_2; pfam12848 1322246010921 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1322246010922 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 1322246010923 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1322246010924 substrate binding site [chemical binding]; other site 1322246010925 hexamer interface [polypeptide binding]; other site 1322246010926 metal binding site [ion binding]; metal-binding site 1322246010927 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1322246010928 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 1322246010929 putative heme d1 biosynthesis radical SAM protein NirJ2; Region: rSAM_NirJ2; TIGR04055 1322246010930 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1322246010931 FeS/SAM binding site; other site 1322246010932 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 1322246010933 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 1322246010934 dimer interface [polypeptide binding]; other site 1322246010935 active site 1322246010936 Schiff base residues; other site 1322246010937 putative heme d1 biosynthesis radical SAM protein NirJ1; Region: rSAM_NirJ1; TIGR04054 1322246010938 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1322246010939 FeS/SAM binding site; other site 1322246010940 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 1322246010941 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1322246010942 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1322246010943 ligand binding site [chemical binding]; other site 1322246010944 zinc-ribbon domain; Region: zinc_ribbon_4; pfam13717 1322246010945 Yip1 domain; Region: Yip1; pfam04893 1322246010946 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1322246010947 active site 1322246010948 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp2; TIGR03088 1322246010949 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1322246010950 Flagellin-specific chaperone FliS [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliS; COG1516 1322246010951 flagellar capping protein; Provisional; Region: PRK12765 1322246010952 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 1322246010953 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 1322246010954 flagellin; Provisional; Region: PRK12804 1322246010955 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1322246010956 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1322246010957 DUF based on E. rectale Gene description (DUF3880); Region: DUF3880; pfam12996 1322246010958 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 1322246010959 Zinc dependent phospholipase C; Region: Zn_dep_PLPC; pfam00882 1322246010960 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1322246010961 active site 1322246010962 Protein of unknown function (DUF2721); Region: DUF2721; pfam11026 1322246010963 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847