-- dump date   	20140619_064939
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
653733000001	DnaA N-terminal domain; Region: DnaA_N; pfam11638
653733000002	chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362
653733000003	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
653733000004	Walker A motif; other site
653733000005	ATP binding site [chemical binding]; other site
653733000006	Walker B motif; other site
653733000007	arginine finger; other site
653733000008	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
653733000009	DnaA box-binding interface [nucleotide binding]; other site
653733000010	DNA polymerase III subunit beta; Validated; Region: PRK05643
653733000011	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
653733000012	putative DNA binding surface [nucleotide binding]; other site
653733000013	dimer interface [polypeptide binding]; other site
653733000014	beta-clamp/clamp loader binding surface; other site
653733000015	beta-clamp/translesion DNA polymerase binding surface; other site
653733000016	recombination protein F; Reviewed; Region: recF; PRK00064
653733000017	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
653733000018	Walker A/P-loop; other site
653733000019	ATP binding site [chemical binding]; other site
653733000020	Q-loop/lid; other site
653733000021	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
653733000022	ABC transporter signature motif; other site
653733000023	Walker B; other site
653733000024	D-loop; other site
653733000025	H-loop/switch region; other site
653733000026	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
653733000027	homotrimer interaction site [polypeptide binding]; other site
653733000028	putative active site [active]
653733000029	Uncharacterized conserved protein [Function unknown]; Region: COG0062
653733000030	putative carbohydrate kinase; Provisional; Region: PRK10565
653733000031	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
653733000032	putative substrate binding site [chemical binding]; other site
653733000033	putative ATP binding site [chemical binding]; other site
653733000034	Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047
653733000035	Helix-Turn-Helix DNA binding domain of the CadR and PbrR transcription regulators; Region: HTH_CadR-PbrR; cd04784
653733000036	DNA binding residues [nucleotide binding]
653733000037	dimer interface [polypeptide binding]; other site
653733000038	putative metal binding site [ion binding]; other site
653733000039	Heavy-metal-associated domain; Region: HMA; pfam00403
653733000040	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
653733000041	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
653733000042	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
653733000043	Integrase core domain; Region: rve; pfam00665
653733000044	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
653733000045	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
653733000046	Coenzyme A binding pocket [chemical binding]; other site
653733000047	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
653733000048	dihydropteroate synthase; Region: DHPS; TIGR01496
653733000049	substrate binding pocket [chemical binding]; other site
653733000050	dimer interface [polypeptide binding]; other site
653733000051	inhibitor binding site; inhibition site
653733000052	Small Multidrug Resistance protein; Region: Multi_Drug_Res; pfam00893
653733000053	aminoglycoside resistance protein; Provisional; Region: PRK13746
653733000054	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
653733000055	active site
653733000056	NTP binding site [chemical binding]; other site
653733000057	metal binding triad [ion binding]; metal-binding site
653733000058	antibiotic binding site [chemical binding]; other site
653733000059	Domain of unknown function (DUF4111); Region: DUF4111; pfam13427
653733000060	integrase/recombinase; Provisional; Region: PRK15417
653733000061	IntI (E2) integrases, site-specific tyrosine recombinases, DNA breaking-rejoining enzymes, N- and C-terminal domains. This CD includes integrases which are components of multiresistant integrons and mediate recombination between a proximal attI site and...; Region: INT_IntI; cd01193
653733000062	Int/Topo IB signature motif; other site
653733000063	Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047
653733000064	Helix-Turn-Helix DNA binding domain of the CadR and PbrR transcription regulators; Region: HTH_CadR-PbrR; cd04784
653733000065	DNA binding residues [nucleotide binding]
653733000066	dimer interface [polypeptide binding]; other site
653733000067	putative metal binding site [ion binding]; other site
653733000068	Heavy-metal-associated domain; Region: HMA; pfam00403
653733000069	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
653733000070	lipoprotein signal peptidase; Provisional; Region: PRK14776
653733000071	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
653733000072	Transposase; Region: DDE_Tnp_ISL3; pfam01610
653733000073	DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974
653733000074	isopropylmalate/citramalate/homocitrate synthases; Region: LEU1_arch; TIGR02090
653733000075	active site
653733000076	catalytic residues [active]
653733000077	metal binding site [ion binding]; metal-binding site
653733000078	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
653733000079	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
653733000080	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
653733000081	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
653733000082	metal binding site [ion binding]; metal-binding site
653733000083	active site
653733000084	I-site; other site
653733000085	decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508
653733000086	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
653733000087	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
653733000088	active site
653733000089	phosphorylation site [posttranslational modification]
653733000090	intermolecular recognition site; other site
653733000091	dimerization interface [polypeptide binding]; other site
653733000092	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
653733000093	Walker A motif; other site
653733000094	ATP binding site [chemical binding]; other site
653733000095	Walker B motif; other site
653733000096	arginine finger; other site
653733000097	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
653733000098	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
653733000099	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
653733000100	dimerization interface [polypeptide binding]; other site
653733000101	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
653733000102	dimer interface [polypeptide binding]; other site
653733000103	phosphorylation site [posttranslational modification]
653733000104	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
653733000105	ATP binding site [chemical binding]; other site
653733000106	Mg2+ binding site [ion binding]; other site
653733000107	G-X-G motif; other site
653733000108	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974
653733000109	Uncharacterized conserved protein [Function unknown]; Region: COG0327
653733000110	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
653733000111	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323
653733000112	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
653733000113	Uncharacterized conserved protein [Function unknown]; Region: COG0327
653733000114	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
653733000115	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
653733000116	Zn2+ binding site [ion binding]; other site
653733000117	Mg2+ binding site [ion binding]; other site
653733000118	PAS domain; Region: PAS_9; pfam13426
653733000119	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
653733000120	putative active site [active]
653733000121	heme pocket [chemical binding]; other site
653733000122	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
653733000123	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
653733000124	metal binding site [ion binding]; metal-binding site
653733000125	active site
653733000126	I-site; other site
653733000127	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
653733000128	Ligand Binding Site [chemical binding]; other site
653733000129	DctM-like transporters; Region: DctM; pfam06808
653733000130	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
653733000131	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290
653733000132	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
653733000133	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
653733000134	Outer membrane efflux protein; Region: OEP; pfam02321
653733000135	Outer membrane efflux protein; Region: OEP; pfam02321
653733000136	copper/silver efflux system membrane fusion protein CusB; Provisional; Region: PRK09783
653733000137	HlyD family secretion protein; Region: HlyD_3; pfam13437
653733000138	Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604
653733000139	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
653733000140	Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604
653733000141	Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604
653733000142	Helix-turn-helix domain; Region: HTH_17; pfam12728
653733000143	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
653733000144	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
653733000145	metal-binding site [ion binding]
653733000146	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
653733000147	haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710
653733000148	Protein of unknown function (DUF2933); Region: DUF2933; pfam11666
653733000149	Helix-turn-helix domain; Region: HTH_17; pfam12728
653733000150	TIGR04255 family protein; Region: sporadTIGR04255
653733000151	Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993
653733000152	Rubrerythrin [Energy production and conversion]; Region: COG1592
653733000153	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
653733000154	dinuclear metal binding motif [ion binding]; other site
653733000155	dihydrodipicolinate reductase; Provisional; Region: PRK00048
653733000156	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
653733000157	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
653733000158	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
653733000159	dihydrodipicolinate synthase; Region: dapA; TIGR00674
653733000160	dimer interface [polypeptide binding]; other site
653733000161	active site
653733000162	catalytic residue [active]
653733000163	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
653733000164	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
653733000165	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
653733000166	diaminopimelate decarboxylase; Region: lysA; TIGR01048
653733000167	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
653733000168	active site
653733000169	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
653733000170	substrate binding site [chemical binding]; other site
653733000171	catalytic residues [active]
653733000172	dimer interface [polypeptide binding]; other site
653733000173	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
653733000174	glutamine synthetase, type I; Region: GlnA; TIGR00653
653733000175	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
653733000176	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
653733000177	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
653733000178	Nitrogen regulatory protein P-II; Region: P-II; smart00938
653733000179	type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710
653733000180	Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334
653733000181	type II secretion system protein I; Region: gspI; TIGR01707
653733000182	Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501
653733000183	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
653733000184	Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612
653733000185	Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934
653733000186	Type II secretion system (T2SS), protein L; Region: T2SL; pfam05134
653733000187	type II secretion system protein L; Region: typeII_sec_gspL; TIGR01709
653733000188	GspL periplasmic domain; Region: GspL_C; pfam12693
653733000189	Type II secretion system (T2SS), protein M; Region: T2SM; pfam04612
653733000190	Cache domain; Region: Cache_2; pfam08269
653733000191	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
653733000192	dimerization interface [polypeptide binding]; other site
653733000193	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
653733000194	dimer interface [polypeptide binding]; other site
653733000195	phosphorylation site [posttranslational modification]
653733000196	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
653733000197	ATP binding site [chemical binding]; other site
653733000198	Mg2+ binding site [ion binding]; other site
653733000199	G-X-G motif; other site
653733000200	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
653733000201	active site
653733000202	phosphorylation site [posttranslational modification]
653733000203	intermolecular recognition site; other site
653733000204	dimerization interface [polypeptide binding]; other site
653733000205	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
653733000206	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
653733000207	active site
653733000208	phosphorylation site [posttranslational modification]
653733000209	intermolecular recognition site; other site
653733000210	dimerization interface [polypeptide binding]; other site
653733000211	PAS domain S-box; Region: sensory_box; TIGR00229
653733000212	PAS domain S-box; Region: sensory_box; TIGR00229
653733000213	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
653733000214	putative active site [active]
653733000215	heme pocket [chemical binding]; other site
653733000216	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
653733000217	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
653733000218	dimer interface [polypeptide binding]; other site
653733000219	phosphorylation site [posttranslational modification]
653733000220	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
653733000221	ATP binding site [chemical binding]; other site
653733000222	Mg2+ binding site [ion binding]; other site
653733000223	G-X-G motif; other site
653733000224	Response regulator receiver domain; Region: Response_reg; pfam00072
653733000225	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
653733000226	active site
653733000227	phosphorylation site [posttranslational modification]
653733000228	intermolecular recognition site; other site
653733000229	dimerization interface [polypeptide binding]; other site
653733000230	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
653733000231	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
653733000232	active site
653733000233	phosphorylation site [posttranslational modification]
653733000234	intermolecular recognition site; other site
653733000235	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
653733000236	TPR repeat; Region: TPR_11; pfam13414
653733000237	binding surface
653733000238	TPR motif; other site
653733000239	FecR protein; Region: FecR; pfam04773
653733000240	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304
653733000241	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
653733000242	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
653733000243	metal binding site [ion binding]; metal-binding site
653733000244	active site
653733000245	I-site; other site
653733000246	Protein of unknown function (DUF721); Region: DUF721; pfam05258
653733000247	putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605
653733000248	Putative catalytic NodB homology domain of uncharacterized bacterial polysaccharide deacetylases which consist of a 5-stranded beta/alpha barrel; Region: CE4_DAC_u4_5s; cd10973
653733000249	putative active site [active]
653733000250	putative metal binding site [ion binding]; other site
653733000251	chemotaxis regulatory protein CheY; Provisional; Region: PRK10610
653733000252	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
653733000253	active site
653733000254	phosphorylation site [posttranslational modification]
653733000255	intermolecular recognition site; other site
653733000256	dimerization interface [polypeptide binding]; other site
653733000257	PilZ domain; Region: PilZ; pfam07238
653733000258	Nitrate and nitrite sensing; Region: NIT; pfam08376
653733000259	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
653733000260	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
653733000261	dimerization interface [polypeptide binding]; other site
653733000262	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
653733000263	dimer interface [polypeptide binding]; other site
653733000264	putative CheW interface [polypeptide binding]; other site
653733000265	Trehalase; Region: Trehalase; cl17346
653733000266	NifQ; Region: NifQ; pfam04891
653733000267	recombinase A; Provisional; Region: recA; PRK09354
653733000268	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
653733000269	hexamer interface [polypeptide binding]; other site
653733000270	Walker A motif; other site
653733000271	ATP binding site [chemical binding]; other site
653733000272	Walker B motif; other site
653733000273	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
653733000274	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
653733000275	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
653733000276	replicative DNA helicase; Region: DnaB; TIGR00665
653733000277	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
653733000278	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
653733000279	Walker A motif; other site
653733000280	ATP binding site [chemical binding]; other site
653733000281	Walker B motif; other site
653733000282	DNA binding loops [nucleotide binding]
653733000283	BCCT family transporter; Region: BCCT; pfam02028
653733000284	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
653733000285	cation diffusion facilitator family transporter; Region: CDF; TIGR01297
653733000286	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
653733000287	Part of AAA domain; Region: AAA_19; pfam13245
653733000288	Family description; Region: UvrD_C_2; pfam13538
653733000289	Global regulator protein family; Region: CsrA; pfam02599
653733000290	flagellar assembly protein FliW; Provisional; Region: PRK13285
653733000291	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
653733000292	binding surface
653733000293	TPR motif; other site
653733000294	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034
653733000295	rod shape-determining protein MreC; Provisional; Region: PRK13922
653733000296	rod shape-determining protein MreC; Region: MreC; pfam04085
653733000297	rod shape-determining protein MreD; Region: MreD; cl01087
653733000298	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
653733000299	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
653733000300	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
653733000301	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
653733000302	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271
653733000303	putative NAD(P) binding site [chemical binding]; other site
653733000304	active site
653733000305	ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaE; COG2870
653733000306	RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172
653733000307	putative ribose interaction site [chemical binding]; other site
653733000308	putative ADP binding site [chemical binding]; other site
653733000309	rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199
653733000310	active site
653733000311	HIGH motif; other site
653733000312	nucleotide binding site [chemical binding]; other site
653733000313	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
653733000314	classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346
653733000315	putative NAD(P) binding site [chemical binding]; other site
653733000316	homodimer interface [polypeptide binding]; other site
653733000317	homotetramer interface [polypeptide binding]; other site
653733000318	active site
653733000319	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
653733000320	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
653733000321	Zn2+ binding site [ion binding]; other site
653733000322	Mg2+ binding site [ion binding]; other site
653733000323	PAS domain S-box; Region: sensory_box; TIGR00229
653733000324	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
653733000325	putative active site [active]
653733000326	heme pocket [chemical binding]; other site
653733000327	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
653733000328	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
653733000329	ATP binding site [chemical binding]; other site
653733000330	Mg2+ binding site [ion binding]; other site
653733000331	G-X-G motif; other site
653733000332	Ammonium Transporter Family; Region: Ammonium_transp; cl03012
653733000333	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
653733000334	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
653733000335	Walker A motif; other site
653733000336	ATP binding site [chemical binding]; other site
653733000337	Walker B motif; other site
653733000338	arginine finger; other site
653733000339	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
653733000340	Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116
653733000341	Walker A motif; other site
653733000342	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
653733000343	trimer interface [polypeptide binding]; other site
653733000344	dimer interface [polypeptide binding]; other site
653733000345	putative active site [active]
653733000346	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
653733000347	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
653733000348	FeS/SAM binding site; other site
653733000349	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
653733000350	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
653733000351	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
653733000352	dimer interface [polypeptide binding]; other site
653733000353	putative functional site; other site
653733000354	putative MPT binding site; other site
653733000355	MoeA_like. This domain is similar to a domain found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. There this domain is presumed to bind molybdopterin. The exact function of this subgroup is...; Region: MoeA_like; cd03522
653733000356	putative MPT binding site; other site
653733000357	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
653733000358	non-specific DNA binding site [nucleotide binding]; other site
653733000359	salt bridge; other site
653733000360	sequence-specific DNA binding site [nucleotide binding]; other site
653733000361	Domain of unknown function (DUF4115); Region: DUF4115; pfam13464
653733000362	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
653733000363	nucleotide binding site [chemical binding]; other site
653733000364	Type III pantothenate kinase; Region: Pan_kinase; cl17198
653733000365	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
653733000366	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
653733000367	dihydroxy-acid dehydratase; Provisional; Region: PRK00911
653733000368	acetolactate synthase 3 catalytic subunit; Reviewed; Region: PRK06048
653733000369	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
653733000370	PYR/PP interface [polypeptide binding]; other site
653733000371	dimer interface [polypeptide binding]; other site
653733000372	TPP binding site [chemical binding]; other site
653733000373	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
653733000374	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
653733000375	TPP-binding site [chemical binding]; other site
653733000376	dimer interface [polypeptide binding]; other site
653733000377	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
653733000378	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
653733000379	putative valine binding site [chemical binding]; other site
653733000380	dimer interface [polypeptide binding]; other site
653733000381	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
653733000382	Response regulator receiver domain; Region: Response_reg; pfam00072
653733000383	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
653733000384	active site
653733000385	phosphorylation site [posttranslational modification]
653733000386	intermolecular recognition site; other site
653733000387	dimerization interface [polypeptide binding]; other site
653733000388	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
653733000389	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
653733000390	PAS fold; Region: PAS_4; pfam08448
653733000391	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
653733000392	putative active site [active]
653733000393	heme pocket [chemical binding]; other site
653733000394	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
653733000395	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
653733000396	dimer interface [polypeptide binding]; other site
653733000397	phosphorylation site [posttranslational modification]
653733000398	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
653733000399	ATP binding site [chemical binding]; other site
653733000400	Mg2+ binding site [ion binding]; other site
653733000401	G-X-G motif; other site
653733000402	LrgA family; Region: LrgA; pfam03788
653733000403	Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346
653733000404	dihydrolipoamide dehydrogenase; Validated; Region: PRK06292
653733000405	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
653733000406	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
653733000407	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
653733000408	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
653733000409	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
653733000410	active site
653733000411	motif I; other site
653733000412	motif II; other site
653733000413	histidinol-phosphatase; Provisional; Region: PRK07328
653733000414	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110
653733000415	active site
653733000416	dimer interface [polypeptide binding]; other site
653733000417	RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724
653733000418	RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399
653733000419	RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724
653733000420	RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399
653733000421	Transcriptional regulators [Transcription]; Region: FadR; COG2186
653733000422	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
653733000423	DNA-binding site [nucleotide binding]; DNA binding site
653733000424	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
653733000425	L-lactate permease [Energy production and conversion]; Region: LldP; COG1620
653733000426	L-lactate permease; Region: Lactate_perm; cl00701
653733000427	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
653733000428	Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139
653733000429	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
653733000430	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
653733000431	Cysteine-rich domain; Region: CCG; pfam02754
653733000432	Cysteine-rich domain; Region: CCG; pfam02754
653733000433	HAMP domain; Region: HAMP; pfam00672
653733000434	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
653733000435	dimer interface [polypeptide binding]; other site
653733000436	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
653733000437	putative CheW interface [polypeptide binding]; other site
653733000438	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
653733000439	FAD binding domain; Region: FAD_binding_4; pfam01565
653733000440	4Fe-4S dicluster domain; Region: Fer4_17; pfam13534
653733000441	Cysteine-rich domain; Region: CCG; pfam02754
653733000442	Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121
653733000443	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
653733000444	putative active site [active]
653733000445	putative dimer interface [polypeptide binding]; other site
653733000446	Membrane transport protein; Region: Mem_trans; cl09117
653733000447	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
653733000448	Peptidase family U32; Region: Peptidase_U32; pfam01136
653733000449	Collagenase; Region: DUF3656; pfam12392
653733000450	Peptidase family U32; Region: Peptidase_U32; cl03113
653733000451	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
653733000452	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
653733000453	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
653733000454	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
653733000455	16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107
653733000456	AAA domain; Region: AAA_31; pfam13614
653733000457	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
653733000458	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
653733000459	triosephosphate isomerase; Provisional; Region: PRK14565
653733000460	substrate binding site [chemical binding]; other site
653733000461	dimer interface [polypeptide binding]; other site
653733000462	catalytic triad [active]
653733000463	Domain of unknown function (DUF3393); Region: DUF3393; pfam11873
653733000464	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
653733000465	N-acetyl-D-glucosamine binding site [chemical binding]; other site
653733000466	catalytic residue [active]
653733000467	Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814
653733000468	Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894
653733000469	isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780
653733000470	Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133
653733000471	conserved cys residue [active]
653733000472	Preprotein translocase subunit SecB; Region: SecB; pfam02556
653733000473	Preprotein binding site; other site
653733000474	SecA binding site; other site
653733000475	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
653733000476	GAF domain; Region: GAF; pfam01590
653733000477	HDOD domain; Region: HDOD; pfam08668
653733000478	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215
653733000479	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
653733000480	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578
653733000481	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
653733000482	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
653733000483	catalytic residue [active]
653733000484	pyrroline-5-carboxylate reductase; Region: PLN02688
653733000485	pyrroline-5-carboxylate reductase; Region: proC; TIGR00112
653733000486	YGGT family; Region: YGGT; pfam02325
653733000487	DivIVA protein; Region: DivIVA; pfam05103
653733000488	Uncharacterized ACR, YggU family COG1872; Region: DUF167; pfam02594
653733000489	methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720
653733000490	S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512
653733000491	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
653733000492	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
653733000493	dimer interface [polypeptide binding]; other site
653733000494	active site
653733000495	metal binding site [ion binding]; metal-binding site
653733000496	glutathione binding site [chemical binding]; other site
653733000497	Protein of unknown function (DUF1622); Region: DUF1622; pfam07784
653733000498	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
653733000499	transmembrane helices; other site
653733000500	TrkA-C domain; Region: TrkA_C; pfam02080
653733000501	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
653733000502	TrkA-C domain; Region: TrkA_C; pfam02080
653733000503	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
653733000504	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
653733000505	dimerization interface [polypeptide binding]; other site
653733000506	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
653733000507	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
653733000508	dimer interface [polypeptide binding]; other site
653733000509	putative CheW interface [polypeptide binding]; other site
653733000510	Protein of unknown function (DUF1049); Region: DUF1049; pfam06305
653733000511	Peptidase family M48; Region: Peptidase_M48; cl12018
653733000512	TPR repeat; Region: TPR_11; pfam13414
653733000513	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
653733000514	binding surface
653733000515	TPR motif; other site
653733000516	Tetratricopeptide repeat; Region: TPR_16; pfam13432
653733000517	Ion transport protein; Region: Ion_trans; pfam00520
653733000518	Protein of unknown function (DUF3373); Region: DUF3373; pfam11853
653733000519	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
653733000520	active site residue [active]
653733000521	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
653733000522	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
653733000523	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
653733000524	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
653733000525	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
653733000526	ATP-grasp domain; Region: ATP-grasp_4; cl17255
653733000527	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
653733000528	IMP binding site; other site
653733000529	dimer interface [polypeptide binding]; other site
653733000530	interdomain contacts; other site
653733000531	partial ornithine binding site; other site
653733000532	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
653733000533	substrate binding site [chemical binding]; other site
653733000534	active site
653733000535	catalytic residues [active]
653733000536	heterodimer interface [polypeptide binding]; other site
653733000537	putative addiction module killer protein; Region: upstrm_HI1419; TIGR02683
653733000538	probable addiction module antidote protein; Region: dnstrm_HI1420; TIGR02684
653733000539	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
653733000540	dimer interface [polypeptide binding]; other site
653733000541	substrate binding site [chemical binding]; other site
653733000542	ATP binding site [chemical binding]; other site
653733000543	Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865
653733000544	Divergent AAA domain; Region: AAA_4; pfam04326
653733000545	ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749
653733000546	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
653733000547	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
653733000548	active site
653733000549	8-oxo-dGMP binding site [chemical binding]; other site
653733000550	nudix motif; other site
653733000551	metal binding site [ion binding]; metal-binding site
653733000552	AAA domain; Region: AAA_14; pfam13173
653733000553	AAA domain; Region: AAA_22; pfam13401
653733000554	Domain of unknown function (DUF4143); Region: DUF4143; pfam13635
653733000555	thiamine monophosphate kinase; Provisional; Region: PRK05731
653733000556	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
653733000557	ATP binding site [chemical binding]; other site
653733000558	dimerization interface [polypeptide binding]; other site
653733000559	Hemerythrin; Region: Hemerythrin; cd12107
653733000560	Fe binding site [ion binding]; other site
653733000561	DNA primase; Validated; Region: dnaG; PRK05667
653733000562	CHC2 zinc finger; Region: zf-CHC2; pfam01807
653733000563	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
653733000564	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
653733000565	active site
653733000566	metal binding site [ion binding]; metal-binding site
653733000567	interdomain interaction site; other site
653733000568	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
653733000569	RNA polymerase sigma factor RpoD; Validated; Region: PRK05658
653733000570	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
653733000571	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
653733000572	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
653733000573	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
653733000574	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
653733000575	DNA binding residues [nucleotide binding]
653733000576	Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075
653733000577	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
653733000578	catalytic residue [active]
653733000579	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581
653733000580	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
653733000581	ligand binding site [chemical binding]; other site
653733000582	NAD binding site [chemical binding]; other site
653733000583	dimerization interface [polypeptide binding]; other site
653733000584	catalytic site [active]
653733000585	C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902
653733000586	putative L-serine binding site [chemical binding]; other site
653733000587	Histidyl-tRNA synthetase; Region: tRNA-synt_His; pfam13393
653733000588	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
653733000589	dimer interface [polypeptide binding]; other site
653733000590	motif 1; other site
653733000591	active site
653733000592	motif 2; other site
653733000593	motif 3; other site
653733000594	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
653733000595	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
653733000596	GDP-binding site [chemical binding]; other site
653733000597	ACT binding site; other site
653733000598	IMP binding site; other site
653733000599	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
653733000600	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
653733000601	Predicted membrane protein (DUF2318); Region: DUF2318; pfam10080
653733000602	D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892
653733000603	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
653733000604	putative active site [active]
653733000605	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
653733000606	3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450
653733000607	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
653733000608	Ligand binding site; other site
653733000609	oligomer interface; other site
653733000610	2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK12457
653733000611	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
653733000612	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
653733000613	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
653733000614	Serine hydrolase; Region: Ser_hydrolase; cl17834
653733000615	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
653733000616	MraW methylase family; Region: Methyltransf_5; cl17771
653733000617	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
653733000618	HSP70 interaction site [polypeptide binding]; other site
653733000619	HEAT repeats; Region: HEAT_2; pfam13646
653733000620	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
653733000621	NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181
653733000622	active site
653733000623	Substrate binding site; other site
653733000624	Mg++ binding site; other site
653733000625	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
653733000626	putative trimer interface [polypeptide binding]; other site
653733000627	putative CoA binding site [chemical binding]; other site
653733000628	phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990
653733000629	The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757
653733000630	active site
653733000631	substrate binding site [chemical binding]; other site
653733000632	metal binding site [ion binding]; metal-binding site
653733000633	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
653733000634	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
653733000635	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
653733000636	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
653733000637	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
653733000638	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
653733000639	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
653733000640	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
653733000641	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
653733000642	Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804
653733000643	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
653733000644	Walker A motif; other site
653733000645	ATP binding site [chemical binding]; other site
653733000646	Walker B motif; other site
653733000647	Bacterial SH3 domain; Region: SH3_3; pfam08239
653733000648	Bacterial SH3 domain; Region: SH3_3; pfam08239
653733000649	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
653733000650	Tetratricopeptide repeat; Region: TPR_16; pfam13432
653733000651	binding surface
653733000652	TPR motif; other site
653733000653	C-terminal domain of homeodomain 1; Region: Mating_C; pfam12737
653733000654	pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519
653733000655	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
653733000656	Type II secretion system (T2SS), protein M; Region: T2SM; cl01222
653733000657	Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972
653733000658	Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191
653733000659	N-terminal catalytic domain of thermoactive amylopullulanases; glycoside hydrolase family 57 (GH57); Region: GH57N_APU; cd10796
653733000660	putative active site [active]
653733000661	catalytic site [active]
653733000662	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
653733000663	Ligand Binding Site [chemical binding]; other site
653733000664	universal stress protein UspE; Provisional; Region: PRK11175
653733000665	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
653733000666	Ligand Binding Site [chemical binding]; other site
653733000667	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
653733000668	homodimer interface [polypeptide binding]; other site
653733000669	glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093
653733000670	active site pocket [active]
653733000671	Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371
653733000672	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
653733000673	active site
653733000674	NAD binding site [chemical binding]; other site
653733000675	metal binding site [ion binding]; metal-binding site
653733000676	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
653733000677	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
653733000678	putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344
653733000679	Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941
653733000680	active site
653733000681	catalytic residues [active]
653733000682	metal binding site [ion binding]; metal-binding site
653733000683	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
653733000684	mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479
653733000685	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
653733000686	Substrate binding site; other site
653733000687	Cupin domain; Region: Cupin_2; cl17218
653733000688	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
653733000689	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_4; cd03795
653733000690	putative ADP-binding pocket [chemical binding]; other site
653733000691	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
653733000692	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
653733000693	NADP-binding site; other site
653733000694	homotetramer interface [polypeptide binding]; other site
653733000695	substrate binding site [chemical binding]; other site
653733000696	homodimer interface [polypeptide binding]; other site
653733000697	active site
653733000698	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
653733000699	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
653733000700	NAD(P) binding site [chemical binding]; other site
653733000701	active site
653733000702	CHASE2 domain; Region: CHASE2; pfam05226
653733000703	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
653733000704	cyclase homology domain; Region: CHD; cd07302
653733000705	nucleotidyl binding site; other site
653733000706	metal binding site [ion binding]; metal-binding site
653733000707	dimer interface [polypeptide binding]; other site
653733000708	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
653733000709	binding surface
653733000710	Tetratricopeptide repeat; Region: TPR_16; pfam13432
653733000711	TPR motif; other site
653733000712	exopolysaccharide biosynthesis operon protein EpsL; Region: EpsL; TIGR03014
653733000713	FecR protein; Region: FecR; pfam04773
653733000714	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
653733000715	Protein of unknown function (DUF1566); Region: DUF1566; pfam07603
653733000716	Protein of unknown function (DUF1566); Region: DUF1566; pfam07603
653733000717	Bacterial sugar transferase; Region: Bac_transf; pfam02397
653733000718	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
653733000719	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
653733000720	HlyD family secretion protein; Region: HlyD_3; pfam13437
653733000721	ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618
653733000722	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
653733000723	ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246
653733000724	Walker A/P-loop; other site
653733000725	ATP binding site [chemical binding]; other site
653733000726	Q-loop/lid; other site
653733000727	ABC transporter signature motif; other site
653733000728	Walker B; other site
653733000729	D-loop; other site
653733000730	H-loop/switch region; other site
653733000731	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
653733000732	phosphomannomutase CpsG; Provisional; Region: PRK15414
653733000733	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
653733000734	active site
653733000735	substrate binding site [chemical binding]; other site
653733000736	metal binding site [ion binding]; metal-binding site
653733000737	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
653733000738	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
653733000739	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
653733000740	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
653733000741	Walker A/P-loop; other site
653733000742	ATP binding site [chemical binding]; other site
653733000743	Q-loop/lid; other site
653733000744	ABC transporter signature motif; other site
653733000745	Walker B; other site
653733000746	D-loop; other site
653733000747	H-loop/switch region; other site
653733000748	C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147
653733000749	putative carbohydrate binding site [chemical binding]; other site
653733000750	Methyltransferase domain; Region: Methyltransf_23; pfam13489
653733000751	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
653733000752	S-adenosylmethionine binding site [chemical binding]; other site
653733000753	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
653733000754	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
653733000755	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
653733000756	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
653733000757	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
653733000758	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
653733000759	glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182
653733000760	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
653733000761	Ligand binding site; other site
653733000762	Putative Catalytic site; other site
653733000763	DXD motif; other site
653733000764	Protein of unknown function (DUF1566); Region: DUF1566; pfam07603
653733000765	Protein of unknown function (DUF1566); Region: DUF1566; pfam07603
653733000766	Predicted methyltransferase regulatory domain; Region: MethyTransf_Reg; pfam10119
653733000767	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
653733000768	putative transposase; Provisional; Region: PRK09857
653733000769	Domain of unknown function (DUF4351); Region: DUF4351; pfam14261
653733000770	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
653733000771	Uncharacterized conserved protein [Function unknown]; Region: COG5464
653733000772	Domain of unknown function (DUF4351); Region: DUF4351; pfam14261
653733000773	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
653733000774	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
653733000775	active site
653733000776	tetramer interface; other site
653733000777	Protein of unknown function DUF86; Region: DUF86; cl01031
653733000778	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
653733000779	active site
653733000780	NTP binding site [chemical binding]; other site
653733000781	metal binding triad [ion binding]; metal-binding site
653733000782	antibiotic binding site [chemical binding]; other site
653733000783	Clp amino terminal domain; Region: Clp_N; pfam02861
653733000784	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
653733000785	Clp amino terminal domain; Region: Clp_N; pfam02861
653733000786	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
653733000787	Walker A motif; other site
653733000788	ATP binding site [chemical binding]; other site
653733000789	Walker B motif; other site
653733000790	arginine finger; other site
653733000791	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
653733000792	Walker A motif; other site
653733000793	ATP binding site [chemical binding]; other site
653733000794	Walker B motif; other site
653733000795	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
653733000796	Quinolinate synthetase A protein; Region: NadA; pfam02445
653733000797	Protein of unknown function DUF45; Region: DUF45; pfam01863
653733000798	TIGR03546 family protein; Region: TIGR03546
653733000799	TIGR03545 family protein; Region: TIGR03545
653733000800	RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966
653733000801	tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617
653733000802	metal binding triad [ion binding]; metal-binding site
653733000803	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
653733000804	tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735
653733000805	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
653733000806	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
653733000807	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
653733000808	shikimate binding site; other site
653733000809	NAD(P) binding site [chemical binding]; other site
653733000810	Protein of unknown function (DUF494); Region: DUF494; cl01103
653733000811	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
653733000812	DNA protecting protein DprA; Region: dprA; TIGR00732
653733000813	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
653733000814	DHH family; Region: DHH; pfam01368
653733000815	FOG: CBS domain [General function prediction only]; Region: COG0517
653733000816	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
653733000817	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
653733000818	tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617
653733000819	active site
653733000820	NTP binding site [chemical binding]; other site
653733000821	metal binding triad [ion binding]; metal-binding site
653733000822	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
653733000823	histidinol-phosphatase; Reviewed; Region: PRK08123
653733000824	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110
653733000825	active site
653733000826	dimer interface [polypeptide binding]; other site
653733000827	Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918
653733000828	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_4; cd07822
653733000829	putative hydrophobic ligand binding site [chemical binding]; other site
653733000830	Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049
653733000831	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
653733000832	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304
653733000833	dimerization interface [polypeptide binding]; other site
653733000834	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
653733000835	dimer interface [polypeptide binding]; other site
653733000836	putative CheW interface [polypeptide binding]; other site
653733000837	FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047
653733000838	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
653733000839	ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614
653733000840	Dinitrogenase reductase ADP-ribosyltransferase (DRAT); Region: DRAT; pfam07357
653733000841	NifZ domain; Region: NifZ; pfam04319
653733000842	ferredoxin III, nif-specific; Region: fdxN_nitrog; TIGR02936
653733000843	The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia.  This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775
653733000844	nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283
653733000845	Nitrogenase_nifN1: A subgroup of the NifN subunit of the NifEN complex: NifN forms an alpha2beta2 tetramer with NifE.  NifN and nifE are structurally homologous to nitrogenase MoFe protein beta and alpha subunits respectively.  NifEN participates in the...; Region: Nitrogenase_NifN_1; cd01966
653733000846	Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148
653733000847	NifX belongs to a family of iron-molybdenum cluster-binding proteins that includes NifB,  and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme.  The protein...; Region: NifX; cd00853
653733000848	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
653733000849	active site
653733000850	NTP binding site [chemical binding]; other site
653733000851	metal binding triad [ion binding]; metal-binding site
653733000852	antibiotic binding site [chemical binding]; other site
653733000853	Nucleotidyltransferase substrate binding protein like; Region: NTase_sub_bind; pfam08780
653733000854	Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910
653733000855	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
653733000856	Mechanosensitive ion channel; Region: MS_channel; pfam00924
653733000857	Protein of unknown function, DUF269; Region: DUF269; cl03973
653733000858	RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724
653733000859	RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399
653733000860	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
653733000861	Ligand Binding Site [chemical binding]; other site
653733000862	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
653733000863	Ligand Binding Site [chemical binding]; other site
653733000864	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
653733000865	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
653733000866	Sulfate transporter family; Region: Sulfate_transp; pfam00916
653733000867	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
653733000868	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
653733000869	TRAM domain; Region: TRAM; cl01282
653733000870	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
653733000871	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
653733000872	S-adenosylmethionine binding site [chemical binding]; other site
653733000873	Cupin domain; Region: Cupin_2; cl17218
653733000874	ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686
653733000875	ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040
653733000876	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
653733000877	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
653733000878	hinge; other site
653733000879	active site
653733000880	GxxExxY protein; Region: GxxExxY; TIGR04256
653733000881	Glutamine synthetase adenylyltransferase [Posttranslational modification, protein turnover, chaperones / Signal transduction mechanisms]; Region: GlnE; COG1391
653733000882	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
653733000883	metal binding triad; other site
653733000884	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
653733000885	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
653733000886	metal binding triad; other site
653733000887	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
653733000888	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
653733000889	bacterial Hfq-like; Region: Hfq; cd01716
653733000890	hexamer interface [polypeptide binding]; other site
653733000891	Sm1 motif; other site
653733000892	RNA binding site [nucleotide binding]; other site
653733000893	Sm2 motif; other site
653733000894	O-Antigen ligase; Region: Wzy_C; pfam04932
653733000895	TupA-like ATPgrasp; Region: ATPgrasp_TupA; pfam14305
653733000896	PhoP regulatory network protein YrbL; Region: YrbL-PhoP_reg; cl17608
653733000897	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
653733000898	N-terminal domain of Chondroitin polymerase functions as a GalNAc transferase; Region: GT2_Chondriotin_Pol_N; cd06420
653733000899	Substrate binding site; other site
653733000900	metal-binding site
653733000901	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
653733000902	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
653733000903	Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532
653733000904	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
653733000905	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
653733000906	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
653733000907	Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249
653733000908	dimer interface [polypeptide binding]; other site
653733000909	substrate binding site [chemical binding]; other site
653733000910	metal binding site [ion binding]; metal-binding site
653733000911	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
653733000912	dimerization interface [polypeptide binding]; other site
653733000913	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
653733000914	Zn2+ binding site [ion binding]; other site
653733000915	Mg2+ binding site [ion binding]; other site
653733000916	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
653733000917	Transcriptional regulator [Transcription]; Region: IclR; COG1414
653733000918	Bacterial transcriptional regulator; Region: IclR; pfam01614
653733000919	seryl-tRNA synthetase; Provisional; Region: PRK05431
653733000920	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
653733000921	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
653733000922	dimer interface [polypeptide binding]; other site
653733000923	active site
653733000924	motif 1; other site
653733000925	motif 2; other site
653733000926	motif 3; other site
653733000927	Predicted membrane protein [Function unknown]; Region: COG2860
653733000928	UPF0126 domain; Region: UPF0126; pfam03458
653733000929	UPF0126 domain; Region: UPF0126; pfam03458
653733000930	2-isopropylmalate synthase; Validated; Region: PRK00915
653733000931	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
653733000932	active site
653733000933	catalytic residues [active]
653733000934	metal binding site [ion binding]; metal-binding site
653733000935	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502
653733000936	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
653733000937	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
653733000938	phosphatidylserine decarboxylase; Provisional; Region: PRK05305
653733000939	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
653733000940	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
653733000941	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
653733000942	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
653733000943	Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804
653733000944	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
653733000945	Walker A motif; other site
653733000946	ATP binding site [chemical binding]; other site
653733000947	Walker B motif; other site
653733000948	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
653733000949	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
653733000950	CoA-ligase; Region: Ligase_CoA; pfam00549
653733000951	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
653733000952	CoA binding domain; Region: CoA_binding; smart00881
653733000953	CoA-ligase; Region: Ligase_CoA; pfam00549
653733000954	bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232
653733000955	Malic enzyme, N-terminal domain; Region: malic; pfam00390
653733000956	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
653733000957	putative NAD(P) binding site [chemical binding]; other site
653733000958	Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280
653733000959	RmuC family; Region: RmuC; pfam02646
653733000960	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
653733000961	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
653733000962	ADP-ribose binding site [chemical binding]; other site
653733000963	dimer interface [polypeptide binding]; other site
653733000964	active site
653733000965	nudix motif; other site
653733000966	metal binding site [ion binding]; metal-binding site
653733000967	Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066
653733000968	glutaminase; Provisional; Region: PRK00971
653733000969	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
653733000970	Beta-lactamase; Region: Beta-lactamase; pfam00144
653733000971	AAA domain; Region: AAA_14; pfam13173
653733000972	Domain of unknown function (DUF4143); Region: DUF4143; pfam13635
653733000973	transferase 1, rSAM/selenodomain-associated; Region: glyco_like_cofC; TIGR04282
653733000974	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
653733000975	transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283
653733000976	active site
653733000977	Uncharacterized conserved protein [Function unknown]; Region: COG0398
653733000978	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
653733000979	mercuric reductase; Validated; Region: PRK06370
653733000980	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
653733000981	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
653733000982	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
653733000983	RNA polymerase sigma factor; Provisional; Region: PRK12512
653733000984	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
653733000985	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
653733000986	DNA binding residues [nucleotide binding]
653733000987	Protein of unknown function (DUF1109); Region: DUF1109; pfam06532
653733000988	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
653733000989	TrkA-N domain; Region: TrkA_N; pfam02254
653733000990	TrkA-C domain; Region: TrkA_C; pfam02080
653733000991	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
653733000992	Cation transport protein; Region: TrkH; pfam02386
653733000993	Methyltransferase domain; Region: Methyltransf_23; pfam13489
653733000994	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
653733000995	S-adenosylmethionine binding site [chemical binding]; other site
653733000996	DsrE/DsrF-like family; Region: DrsE; pfam02635
653733000997	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
653733000998	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
653733000999	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
653733001000	catalytic residue [active]
653733001001	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
653733001002	dimerization interface [polypeptide binding]; other site
653733001003	putative DNA binding site [nucleotide binding]; other site
653733001004	putative Zn2+ binding site [ion binding]; other site
653733001005	Uncharacterized conserved protein [Function unknown]; Region: COG2128
653733001006	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
653733001007	Protein of unknown function (DUF3047); Region: DUF3047; pfam11249
653733001008	radical SAM/Cys-rich domain protein; Region: rSAM_SeCys; TIGR04167
653733001009	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
653733001010	FeS/SAM binding site; other site
653733001011	Protein of unknown function (DUF3641); Region: DUF3641; pfam12345
653733001012	5-oxoprolinase; Region: PLN02666
653733001013	Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378
653733001014	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968
653733001015	N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146
653733001016	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
653733001017	S17 interaction site [polypeptide binding]; other site
653733001018	S8 interaction site; other site
653733001019	16S rRNA interaction site [nucleotide binding]; other site
653733001020	streptomycin interaction site [chemical binding]; other site
653733001021	23S rRNA interaction site [nucleotide binding]; other site
653733001022	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
653733001023	30S ribosomal protein S7; Validated; Region: PRK05302
653733001024	elongation factor G; Reviewed; Region: PRK00007
653733001025	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
653733001026	G1 box; other site
653733001027	putative GEF interaction site [polypeptide binding]; other site
653733001028	GTP/Mg2+ binding site [chemical binding]; other site
653733001029	Switch I region; other site
653733001030	G2 box; other site
653733001031	G3 box; other site
653733001032	Switch II region; other site
653733001033	G4 box; other site
653733001034	G5 box; other site
653733001035	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
653733001036	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
653733001037	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
653733001038	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
653733001039	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
653733001040	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
653733001041	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
653733001042	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
653733001043	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
653733001044	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
653733001045	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
653733001046	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
653733001047	putative translocon binding site; other site
653733001048	protein-rRNA interface [nucleotide binding]; other site
653733001049	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
653733001050	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
653733001051	G-X-X-G motif; other site
653733001052	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
653733001053	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
653733001054	23S rRNA interface [nucleotide binding]; other site
653733001055	5S rRNA interface [nucleotide binding]; other site
653733001056	putative antibiotic binding site [chemical binding]; other site
653733001057	L25 interface [polypeptide binding]; other site
653733001058	L27 interface [polypeptide binding]; other site
653733001059	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
653733001060	putative translocon interaction site; other site
653733001061	23S rRNA interface [nucleotide binding]; other site
653733001062	signal recognition particle (SRP54) interaction site; other site
653733001063	L23 interface [polypeptide binding]; other site
653733001064	trigger factor interaction site; other site
653733001065	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
653733001066	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
653733001067	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
653733001068	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
653733001069	RNA binding site [nucleotide binding]; other site
653733001070	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
653733001071	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
653733001072	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
653733001073	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061
653733001074	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
653733001075	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
653733001076	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
653733001077	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
653733001078	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
653733001079	5S rRNA interface [nucleotide binding]; other site
653733001080	23S rRNA interface [nucleotide binding]; other site
653733001081	L5 interface [polypeptide binding]; other site
653733001082	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
653733001083	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
653733001084	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
653733001085	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30_like; cl00203
653733001086	23S rRNA binding site - archaea [nucleotide binding]; other site
653733001087	23S rRNA binding site - prokaryotes [nucleotide binding]; other site
653733001088	5S rRNA binding site - archaea; other site
653733001089	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
653733001090	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
653733001091	SecY translocase; Region: SecY; pfam00344
653733001092	adenylate kinase; Reviewed; Region: adk; PRK00279
653733001093	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
653733001094	AMP-binding site [chemical binding]; other site
653733001095	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
653733001096	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
653733001097	rRNA binding site [nucleotide binding]; other site
653733001098	predicted 30S ribosome binding site; other site
653733001099	Ribosomal protein L36; Region: Ribosomal_L36; cl00380
653733001100	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
653733001101	30S ribosomal protein S13; Region: bact_S13; TIGR03631
653733001102	30S ribosomal protein S11; Validated; Region: PRK05309
653733001103	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
653733001104	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
653733001105	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
653733001106	RNA binding surface [nucleotide binding]; other site
653733001107	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
653733001108	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
653733001109	alphaNTD homodimer interface [polypeptide binding]; other site
653733001110	alphaNTD - beta interaction site [polypeptide binding]; other site
653733001111	alphaNTD - beta' interaction site [polypeptide binding]; other site
653733001112	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
653733001113	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
653733001114	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581
653733001115	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
653733001116	ligand binding site [chemical binding]; other site
653733001117	NAD binding site [chemical binding]; other site
653733001118	dimerization interface [polypeptide binding]; other site
653733001119	catalytic site [active]
653733001120	C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902
653733001121	putative L-serine binding site [chemical binding]; other site
653733001122	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
653733001123	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
653733001124	active site
653733001125	Riboflavin kinase; Region: Flavokinase; pfam01687
653733001126	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
653733001127	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
653733001128	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
653733001129	active site
653733001130	phosphorylation site [posttranslational modification]
653733001131	intermolecular recognition site; other site
653733001132	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
653733001133	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
653733001134	G1 box; other site
653733001135	putative GEF interaction site [polypeptide binding]; other site
653733001136	GTP/Mg2+ binding site [chemical binding]; other site
653733001137	Switch I region; other site
653733001138	G2 box; other site
653733001139	G3 box; other site
653733001140	Switch II region; other site
653733001141	G4 box; other site
653733001142	G5 box; other site
653733001143	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
653733001144	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
653733001145	non-specific DNA binding site [nucleotide binding]; other site
653733001146	salt bridge; other site
653733001147	sequence-specific DNA binding site [nucleotide binding]; other site
653733001148	HipA N-terminal domain; Region: Couple_hipA; pfam13657
653733001149	HipA-like N-terminal domain; Region: HipA_N; pfam07805
653733001150	Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550
653733001151	HipA-like C-terminal domain; Region: HipA_C; pfam07804
653733001152	Uncharacterized membrane protein [Function unknown]; Region: SpmB; cl17667
653733001153	Pirin-related protein [General function prediction only]; Region: COG1741
653733001154	Pirin; Region: Pirin; pfam02678
653733001155	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
653733001156	dimerization interface [polypeptide binding]; other site
653733001157	putative DNA binding site [nucleotide binding]; other site
653733001158	putative Zn2+ binding site [ion binding]; other site
653733001159	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
653733001160	arsenical-resistance protein; Region: acr3; TIGR00832
653733001161	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
653733001162	Low molecular weight phosphatase family; Region: LMWPc; cl00105
653733001163	active site
653733001164	Predicted permease; Region: DUF318; cl17795
653733001165	Predicted permease; Region: DUF318; cl17795
653733001166	Thioredoxin domain; Region: Thioredoxin_3; pfam13192
653733001167	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
653733001168	active site residue [active]
653733001169	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
653733001170	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
653733001171	active site
653733001172	phosphorylation site [posttranslational modification]
653733001173	intermolecular recognition site; other site
653733001174	dimerization interface [polypeptide binding]; other site
653733001175	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
653733001176	DNA binding residues [nucleotide binding]
653733001177	dimerization interface [polypeptide binding]; other site
653733001178	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
653733001179	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
653733001180	dimerization interface [polypeptide binding]; other site
653733001181	Histidine kinase; Region: HisKA_3; pfam07730
653733001182	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
653733001183	ATP binding site [chemical binding]; other site
653733001184	Mg2+ binding site [ion binding]; other site
653733001185	G-X-G motif; other site
653733001186	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974
653733001187	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
653733001188	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
653733001189	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
653733001190	molybdopterin cofactor binding site; other site
653733001191	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
653733001192	This CD contains the molybdopterin_binding C-terminal (MopB_CT) region of tetrathionate reductase, subunit A, (TtrA); respiratory arsenate As(V) reductase, catalytic subunit (ArrA); and other related proteins; Region: MopB_CT_Tetrathionate_Arsenate-R; cd02780
653733001193	putative molybdopterin cofactor binding site; other site
653733001194	Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437
653733001195	Nitrate reductase delta subunit; Region: Nitrate_red_del; pfam02613
653733001196	Ferredoxin [Energy production and conversion]; Region: COG1146
653733001197	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
653733001198	Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519
653733001199	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
653733001200	Peptidase family M23; Region: Peptidase_M23; pfam01551
653733001201	Domain of unknown function (DUF4168); Region: DUF4168; pfam13767
653733001202	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
653733001203	HAMP domain; Region: HAMP; pfam00672
653733001204	dimerization interface [polypeptide binding]; other site
653733001205	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
653733001206	dimer interface [polypeptide binding]; other site
653733001207	phosphorylation site [posttranslational modification]
653733001208	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
653733001209	ATP binding site [chemical binding]; other site
653733001210	Mg2+ binding site [ion binding]; other site
653733001211	G-X-G motif; other site
653733001212	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
653733001213	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
653733001214	active site
653733001215	phosphorylation site [posttranslational modification]
653733001216	intermolecular recognition site; other site
653733001217	dimerization interface [polypeptide binding]; other site
653733001218	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
653733001219	Walker A motif; other site
653733001220	ATP binding site [chemical binding]; other site
653733001221	Walker B motif; other site
653733001222	arginine finger; other site
653733001223	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
653733001224	rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565
653733001225	SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307
653733001226	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
653733001227	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
653733001228	substrate binding site [chemical binding]; other site
653733001229	ligand binding site [chemical binding]; other site
653733001230	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
653733001231	3-isopropylmalate dehydratase, small subunit; Region: leud; TIGR02084
653733001232	substrate binding site [chemical binding]; other site
653733001233	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
653733001234	non-specific DNA binding site [nucleotide binding]; other site
653733001235	salt bridge; other site
653733001236	sequence-specific DNA binding site [nucleotide binding]; other site
653733001237	Domain of unknown function(DUF2779); Region: DUF2779; pfam11074
653733001238	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
653733001239	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
653733001240	Walker A motif; other site
653733001241	ATP binding site [chemical binding]; other site
653733001242	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
653733001243	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
653733001244	Walker A motif; other site
653733001245	ATP binding site [chemical binding]; other site
653733001246	Walker B motif; other site
653733001247	arginine finger; other site
653733001248	AAA ATPase domain; Region: AAA_16; pfam13191
653733001249	putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015
653733001250	Fic family protein [Function unknown]; Region: COG3177
653733001251	Fic/DOC family N-terminal; Region: Fic_N; pfam13784
653733001252	Fic/DOC family; Region: Fic; pfam02661
653733001253	Predicted transcriptional regulator [Transcription]; Region: COG2378
653733001254	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
653733001255	WYL domain; Region: WYL; pfam13280
653733001256	Protein of unknown function DUF86; Region: DUF86; pfam01934
653733001257	NAD synthetase; Reviewed; Region: nadE; PRK02628
653733001258	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
653733001259	multimer interface [polypeptide binding]; other site
653733001260	active site
653733001261	catalytic triad [active]
653733001262	protein interface 1 [polypeptide binding]; other site
653733001263	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
653733001264	homodimer interface [polypeptide binding]; other site
653733001265	NAD binding pocket [chemical binding]; other site
653733001266	ATP binding pocket [chemical binding]; other site
653733001267	Mg binding site [ion binding]; other site
653733001268	active-site loop [active]
653733001269	Colicin V production protein; Region: Colicin_V; pfam02674
653733001270	Yqey-like protein; Region: YqeY; pfam09424
653733001271	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
653733001272	nucleotide binding site/active site [active]
653733001273	HIT family signature motif; other site
653733001274	catalytic residue [active]
653733001275	pentatricopeptide (PPR) repeat-containing protein; Provisional; Region: PLN03081
653733001276	EamA-like transporter family; Region: EamA; cl17759
653733001277	EamA-like transporter family; Region: EamA; cl17759
653733001278	Isochorismatase family; Region: Isochorismatase; pfam00857
653733001279	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012
653733001280	catalytic triad [active]
653733001281	dimer interface [polypeptide binding]; other site
653733001282	conserved cis-peptide bond; other site
653733001283	Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321
653733001284	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
653733001285	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
653733001286	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
653733001287	catalytic center binding site [active]
653733001288	ATP binding site [chemical binding]; other site
653733001289	FxsA cytoplasmic membrane protein; Region: FxsA; pfam04186
653733001290	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
653733001291	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
653733001292	ssDNA binding site; other site
653733001293	generic binding surface II; other site
653733001294	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
653733001295	ATP binding site [chemical binding]; other site
653733001296	putative Mg++ binding site [ion binding]; other site
653733001297	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
653733001298	nucleotide binding region [chemical binding]; other site
653733001299	ATP-binding site [chemical binding]; other site
653733001300	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
653733001301	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
653733001302	Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786
653733001303	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
653733001304	flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490
653733001305	flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693
653733001306	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
653733001307	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
653733001308	SAF-like; Region: SAF_2; pfam13144
653733001309	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
653733001310	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
653733001311	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
653733001312	CoA-binding site [chemical binding]; other site
653733001313	ATP-binding [chemical binding]; other site
653733001314	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
653733001315	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
653733001316	putative acyl-acceptor binding pocket; other site
653733001317	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
653733001318	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143
653733001319	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
653733001320	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
653733001321	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
653733001322	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
653733001323	Mg++ binding site [ion binding]; other site
653733001324	putative catalytic motif [active]
653733001325	putative substrate binding site [chemical binding]; other site
653733001326	UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell envelope biogenesis, outer membrane]; Region: MurD; COG0771
653733001327	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
653733001328	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
653733001329	Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
653733001330	undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Reviewed; Region: PRK12446
653733001331	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
653733001332	active site
653733001333	homodimer interface [polypeptide binding]; other site
653733001334	peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059
653733001335	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
653733001336	SurA N-terminal domain; Region: SurA_N; pfam09312
653733001337	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
653733001338	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
653733001339	RNA binding surface [nucleotide binding]; other site
653733001340	Protein of unknown function (DUF3897); Region: DUF3897; pfam13036
653733001341	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3014
653733001342	LPP20 lipoprotein; Region: LPP20; pfam02169
653733001343	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
653733001344	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
653733001345	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
653733001346	A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448
653733001347	A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168
653733001348	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307
653733001349	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304
653733001350	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
653733001351	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
653733001352	dimer interface [polypeptide binding]; other site
653733001353	putative CheW interface [polypeptide binding]; other site
653733001354	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
653733001355	Response regulator receiver domain; Region: Response_reg; pfam00072
653733001356	active site
653733001357	phosphorylation site [posttranslational modification]
653733001358	intermolecular recognition site; other site
653733001359	dimerization interface [polypeptide binding]; other site
653733001360	Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374
653733001361	Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374
653733001362	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058
653733001363	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
653733001364	dimerization interface [polypeptide binding]; other site
653733001365	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
653733001366	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
653733001367	dimer interface [polypeptide binding]; other site
653733001368	putative CheW interface [polypeptide binding]; other site
653733001369	cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160
653733001370	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
653733001371	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
653733001372	Walker A/P-loop; other site
653733001373	ATP binding site [chemical binding]; other site
653733001374	Q-loop/lid; other site
653733001375	ABC transporter signature motif; other site
653733001376	Walker B; other site
653733001377	D-loop; other site
653733001378	H-loop/switch region; other site
653733001379	Macro domain, Poa1p_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Poa1p_like; cd02901
653733001380	ADP-ribose binding site [chemical binding]; other site
653733001381	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
653733001382	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
653733001383	active site
653733001384	phosphorylation site [posttranslational modification]
653733001385	intermolecular recognition site; other site
653733001386	dimerization interface [polypeptide binding]; other site
653733001387	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
653733001388	Walker A motif; other site
653733001389	ATP binding site [chemical binding]; other site
653733001390	Walker B motif; other site
653733001391	arginine finger; other site
653733001392	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
653733001393	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
653733001394	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
653733001395	dimer interface [polypeptide binding]; other site
653733001396	phosphorylation site [posttranslational modification]
653733001397	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
653733001398	ATP binding site [chemical binding]; other site
653733001399	Mg2+ binding site [ion binding]; other site
653733001400	G-X-G motif; other site
653733001401	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
653733001402	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
653733001403	FMN binding site [chemical binding]; other site
653733001404	active site
653733001405	catalytic residues [active]
653733001406	substrate binding site [chemical binding]; other site
653733001407	Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293
653733001408	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484
653733001409	active site
653733001410	substrate-binding site [chemical binding]; other site
653733001411	metal-binding site [ion binding]
653733001412	ATP binding site [chemical binding]; other site
653733001413	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
653733001414	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
653733001415	active site
653733001416	phosphorylation site [posttranslational modification]
653733001417	intermolecular recognition site; other site
653733001418	dimerization interface [polypeptide binding]; other site
653733001419	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
653733001420	Peptidase family U32; Region: Peptidase_U32; pfam01136
653733001421	Peptidase family U32; Region: Peptidase_U32; cl03113
653733001422	Response regulator receiver domain; Region: Response_reg; pfam00072
653733001423	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
653733001424	active site
653733001425	phosphorylation site [posttranslational modification]
653733001426	dimerization interface [polypeptide binding]; other site
653733001427	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
653733001428	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
653733001429	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
653733001430	Zn2+ binding site [ion binding]; other site
653733001431	Mg2+ binding site [ion binding]; other site
653733001432	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
653733001433	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
653733001434	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
653733001435	dimerization interface [polypeptide binding]; other site
653733001436	active site
653733001437	ribose-5-phosphate isomerase B; Provisional; Region: PRK05571
653733001438	Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239
653733001439	Protein of unknown function (DUF523); Region: DUF523; pfam04463
653733001440	Protein of unknown function (DUF1722); Region: DUF1722; pfam08349
653733001441	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
653733001442	TPR repeat; Region: TPR_11; pfam13414
653733001443	binding surface
653733001444	TPR motif; other site
653733001445	Tetratricopeptide repeat; Region: TPR_16; pfam13432
653733001446	TPR repeat; Region: TPR_11; pfam13414
653733001447	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
653733001448	binding surface
653733001449	TPR motif; other site
653733001450	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
653733001451	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
653733001452	ATP binding site [chemical binding]; other site
653733001453	putative Mg++ binding site [ion binding]; other site
653733001454	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
653733001455	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
653733001456	nucleotide binding region [chemical binding]; other site
653733001457	ATP-binding site [chemical binding]; other site
653733001458	SEC-C motif; Region: SEC-C; pfam02810
653733001459	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
653733001460	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
653733001461	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
653733001462	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
653733001463	Walker A/P-loop; other site
653733001464	ATP binding site [chemical binding]; other site
653733001465	Q-loop/lid; other site
653733001466	ABC transporter signature motif; other site
653733001467	Walker B; other site
653733001468	D-loop; other site
653733001469	H-loop/switch region; other site
653733001470	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
653733001471	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
653733001472	dimer interface [polypeptide binding]; other site
653733001473	conserved gate region; other site
653733001474	ABC-ATPase subunit interface; other site
653733001475	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
653733001476	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
653733001477	substrate binding pocket [chemical binding]; other site
653733001478	membrane-bound complex binding site; other site
653733001479	hinge residues; other site
653733001480	Predicted permeases [General function prediction only]; Region: COG0679
653733001481	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
653733001482	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
653733001483	GatB domain; Region: GatB_Yqey; smart00845
653733001484	GxxExxY protein; Region: GxxExxY; TIGR04256
653733001485	recombination factor protein RarA; Reviewed; Region: PRK13342
653733001486	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
653733001487	Walker A motif; other site
653733001488	ATP binding site [chemical binding]; other site
653733001489	Walker B motif; other site
653733001490	arginine finger; other site
653733001491	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
653733001492	Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652
653733001493	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
653733001494	Domain of unknown function (DUF4351); Region: DUF4351; pfam14261
653733001495	Helix-turn-helix domain; Region: HTH_28; pfam13518
653733001496	Winged helix-turn helix; Region: HTH_29; pfam13551
653733001497	Homeodomain-like domain; Region: HTH_32; pfam13565
653733001498	DDE superfamily endonuclease; Region: DDE_3; pfam13358
653733001499	Helix-turn-helix domain; Region: HTH_28; pfam13518
653733001500	Winged helix-turn helix; Region: HTH_29; pfam13551
653733001501	Homeodomain-like domain; Region: HTH_32; pfam13565
653733001502	DDE superfamily endonuclease; Region: DDE_3; pfam13358
653733001503	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
653733001504	Predicted transcriptional regulator [Transcription]; Region: COG2378
653733001505	HTH domain; Region: HTH_11; cl17392
653733001506	Protein of unknown function (DUF1232); Region: DUF1232; pfam06803
653733001507	PcfJ-like protein; Region: PcfJ; pfam14284
653733001508	Predicted transcriptional regulator [Transcription]; Region: COG2378
653733001509	HTH domain; Region: HTH_11; cl17392
653733001510	WYL domain; Region: WYL; pfam13280
653733001511	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
653733001512	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
653733001513	Walker A motif; other site
653733001514	ATP binding site [chemical binding]; other site
653733001515	AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724
653733001516	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
653733001517	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
653733001518	active site
653733001519	HslU subunit interaction site [polypeptide binding]; other site
653733001520	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
653733001521	Glucose inhibited division protein A; Region: GIDA; pfam01134
653733001522	Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435
653733001523	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
653733001524	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
653733001525	nucleophile elbow; other site
653733001526	bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886
653733001527	Biotin operon repressor [Transcription]; Region: BirA; COG1654
653733001528	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
653733001529	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
653733001530	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
653733001531	adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508
653733001532	inhibitor-cofactor binding pocket; inhibition site
653733001533	pyridoxal 5'-phosphate binding site [chemical binding]; other site
653733001534	catalytic residue [active]
653733001535	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
653733001536	short chain dehydrogenase; Provisional; Region: PRK06125
653733001537	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
653733001538	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
653733001539	active site
653733001540	active site
653733001541	Phosphopantetheine attachment site; Region: PP-binding; cl09936
653733001542	3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304
653733001543	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
653733001544	dimer interface [polypeptide binding]; other site
653733001545	active site
653733001546	7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156
653733001547	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
653733001548	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
653733001549	catalytic residue [active]
653733001550	AAA domain; Region: AAA_26; pfam13500
653733001551	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
653733001552	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
653733001553	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
653733001554	inhibitor-cofactor binding pocket; inhibition site
653733001555	pyridoxal 5'-phosphate binding site [chemical binding]; other site
653733001556	catalytic residue [active]
653733001557	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
653733001558	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
653733001559	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
653733001560	P loop; other site
653733001561	GTP binding site [chemical binding]; other site
653733001562	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
653733001563	active site
653733001564	Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375
653733001565	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
653733001566	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
653733001567	dimerization interface [polypeptide binding]; other site
653733001568	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
653733001569	dimer interface [polypeptide binding]; other site
653733001570	putative CheW interface [polypeptide binding]; other site
653733001571	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
653733001572	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
653733001573	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
653733001574	non-specific DNA binding site [nucleotide binding]; other site
653733001575	salt bridge; other site
653733001576	sequence-specific DNA binding site [nucleotide binding]; other site
653733001577	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
653733001578	Predicted transcriptional regulator [Transcription]; Region: COG2932
653733001579	Catalytic site [active]
653733001580	Protein of unknown function, DUF481; Region: DUF481; pfam04338
653733001581	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
653733001582	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
653733001583	S-adenosylmethionine binding site [chemical binding]; other site
653733001584	Peptidase family M48; Region: Peptidase_M48; cl12018
653733001585	bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558
653733001586	Synechococcus sp. strain PCC 7942  PhoA and related proteins, N-terminal metallophosphatase domain; Region: MPP_PhoA_N; cd08162
653733001587	putative active site [active]
653733001588	putative metal binding site [ion binding]; other site
653733001589	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
653733001590	Protein of unknown function (DUF342); Region: DUF342; pfam03961
653733001591	Protein of unknown function (DUF342); Region: DUF342; pfam03961
653733001592	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
653733001593	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
653733001594	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
653733001595	Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899
653733001596	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4196
653733001597	Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272
653733001598	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
653733001599	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
653733001600	eyelet of channel; other site
653733001601	trimer interface [polypeptide binding]; other site
653733001602	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
653733001603	Haemagglutinin; Region: Hemagglutinin; pfam00509
653733001604	Haemagglutinin; Region: Hemagglutinin; pfam00509
653733001605	Apolipoprotein A1/A4/E domain; Region: Apolipoprotein; pfam01442
653733001606	Herpesvirus UL25 family; Region: Herpes_UL25; pfam01499
653733001607	hydroxylamine reductase; Provisional; Region: PRK12310
653733001608	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
653733001609	ACS interaction site; other site
653733001610	CODH interaction site; other site
653733001611	metal cluster binding site [ion binding]; other site
653733001612	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
653733001613	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
653733001614	ligand binding site [chemical binding]; other site
653733001615	flexible hinge region; other site
653733001616	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
653733001617	non-specific DNA interactions [nucleotide binding]; other site
653733001618	DNA binding site [nucleotide binding]
653733001619	sequence specific DNA binding site [nucleotide binding]; other site
653733001620	putative cAMP binding site [chemical binding]; other site
653733001621	NMT1/THI5 like; Region: NMT1; pfam09084
653733001622	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
653733001623	substrate binding pocket [chemical binding]; other site
653733001624	membrane-bound complex binding site; other site
653733001625	PAS fold; Region: PAS; pfam00989
653733001626	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
653733001627	putative active site [active]
653733001628	heme pocket [chemical binding]; other site
653733001629	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
653733001630	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
653733001631	metal binding site [ion binding]; metal-binding site
653733001632	active site
653733001633	I-site; other site
653733001634	trigger factor; Provisional; Region: tig; PRK01490
653733001635	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
653733001636	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
653733001637	Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740
653733001638	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
653733001639	oligomer interface [polypeptide binding]; other site
653733001640	active site residues [active]
653733001641	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
653733001642	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
653733001643	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
653733001644	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
653733001645	Walker A motif; other site
653733001646	ATP binding site [chemical binding]; other site
653733001647	Walker B motif; other site
653733001648	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
653733001649	ferredoxin-NADP(+) reductase subunit alpha; Reviewed; Region: PRK06222
653733001650	FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)...; Region: DHOD_e_trans_like1; cd06219
653733001651	FAD binding pocket [chemical binding]; other site
653733001652	FAD binding motif [chemical binding]; other site
653733001653	phosphate binding motif [ion binding]; other site
653733001654	beta-alpha-beta structure motif; other site
653733001655	NAD binding pocket [chemical binding]; other site
653733001656	Iron coordination center [ion binding]; other site
653733001657	putative oxidoreductase; Provisional; Region: PRK12831
653733001658	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
653733001659	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
653733001660	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
653733001661	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
653733001662	Protein of unknown function (DUF342); Region: DUF342; pfam03961
653733001663	Protein of unknown function DUF116; Region: DUF116; pfam01976
653733001664	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
653733001665	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
653733001666	putative active site [active]
653733001667	substrate binding site [chemical binding]; other site
653733001668	putative cosubstrate binding site; other site
653733001669	catalytic site [active]
653733001670	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
653733001671	substrate binding site [chemical binding]; other site
653733001672	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
653733001673	active site
653733001674	catalytic residues [active]
653733001675	metal binding site [ion binding]; metal-binding site
653733001676	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
653733001677	Glycosyltransferase family 9 (heptosyltransferase); Region: Glyco_transf_9; pfam01075
653733001678	putative active site [active]
653733001679	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
653733001680	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
653733001681	putative active site [active]
653733001682	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
653733001683	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
653733001684	Walker A/P-loop; other site
653733001685	ATP binding site [chemical binding]; other site
653733001686	Q-loop/lid; other site
653733001687	ABC transporter signature motif; other site
653733001688	Walker B; other site
653733001689	D-loop; other site
653733001690	H-loop/switch region; other site
653733001691	glutamate racemase; Provisional; Region: PRK00865
653733001692	ribonuclease PH; Reviewed; Region: rph; PRK00173
653733001693	Ribonuclease PH; Region: RNase_PH_bact; cd11362
653733001694	hexamer interface [polypeptide binding]; other site
653733001695	active site
653733001696	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
653733001697	active site
653733001698	dimerization interface [polypeptide binding]; other site
653733001699	rod shape-determining protein MreB; Provisional; Region: PRK13927
653733001700	MreB and similar proteins; Region: MreB_like; cd10225
653733001701	nucleotide binding site [chemical binding]; other site
653733001702	Mg binding site [ion binding]; other site
653733001703	putative protofilament interaction site [polypeptide binding]; other site
653733001704	RodZ interaction site [polypeptide binding]; other site
653733001705	Rrf2 family protein; Region: rrf2_super; TIGR00738
653733001706	Transcriptional regulator; Region: Rrf2; pfam02082
653733001707	NusB family; Region: NusB; pfam01029
653733001708	16S rRNA methyltransferase B; Provisional; Region: PRK10901
653733001709	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
653733001710	S-adenosylmethionine binding site [chemical binding]; other site
653733001711	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
653733001712	SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974
653733001713	sequence-specific DNA binding site [nucleotide binding]; other site
653733001714	salt bridge; other site
653733001715	The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465
653733001716	Catalytic site [active]
653733001717	OstA-like protein; Region: OstA; cl00844
653733001718	Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452
653733001719	folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499
653733001720	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325
653733001721	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
653733001722	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
653733001723	FeS/SAM binding site; other site
653733001724	TRAM domain; Region: TRAM; pfam01938
653733001725	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
653733001726	AIR carboxylase; Region: AIRC; pfam00731
653733001727	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cl00246
653733001728	FAD binding site [chemical binding]; other site
653733001729	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
653733001730	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
653733001731	active site
653733001732	methionyl-tRNA synthetase; Reviewed; Region: PRK12267
653733001733	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
653733001734	active site
653733001735	HIGH motif; other site
653733001736	KMSKS motif; other site
653733001737	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
653733001738	tRNA binding surface [nucleotide binding]; other site
653733001739	anticodon binding site; other site
653733001740	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
653733001741	dimer interface [polypeptide binding]; other site
653733001742	putative tRNA-binding site [nucleotide binding]; other site
653733001743	Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774
653733001744	DNA polymerase III, delta' subunit; Region: holB; TIGR00678
653733001745	DNA polymerase III subunit delta'; Validated; Region: PRK08485
653733001746	thymidylate kinase; Validated; Region: tmk; PRK00698
653733001747	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
653733001748	TMP-binding site; other site
653733001749	ATP-binding site [chemical binding]; other site
653733001750	cupin fold metalloprotein, WbuC family; Region: cupin_WbuC; TIGR04366
653733001751	This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens  ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333
653733001752	putative deacylase active site [active]
653733001753	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215
653733001754	Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473
653733001755	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
653733001756	Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858
653733001757	Cupredoxin-like domain; Region: Cupredoxin_1; cl17234
653733001758	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
653733001759	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
653733001760	Walker A/P-loop; other site
653733001761	ATP binding site [chemical binding]; other site
653733001762	Q-loop/lid; other site
653733001763	ABC transporter signature motif; other site
653733001764	Walker B; other site
653733001765	D-loop; other site
653733001766	H-loop/switch region; other site
653733001767	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
653733001768	FtsX-like permease family; Region: FtsX; pfam02687
653733001769	Domain of unknown function (DUF4418); Region: DUF4418; pfam14387
653733001770	Uncharacterized conserved protein [Function unknown]; Region: COG3391
653733001771	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
653733001772	Cupredoxin-like domain; Region: Cupredoxin_1; cl17234
653733001773	Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626
653733001774	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832
653733001775	This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299
653733001776	putative homodimer interface [polypeptide binding]; other site
653733001777	putative active site pocket [active]
653733001778	alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094
653733001779	ribonuclease III; Reviewed; Region: rnc; PRK00102
653733001780	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
653733001781	dimerization interface [polypeptide binding]; other site
653733001782	active site
653733001783	metal binding site [ion binding]; metal-binding site
653733001784	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
653733001785	dsRNA binding site [nucleotide binding]; other site
653733001786	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
653733001787	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
653733001788	dimer interface [polypeptide binding]; other site
653733001789	active site
653733001790	acyl carrier protein; Provisional; Region: acpP; PRK00982
653733001791	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
653733001792	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
653733001793	NAD(P) binding site [chemical binding]; other site
653733001794	homotetramer interface [polypeptide binding]; other site
653733001795	homodimer interface [polypeptide binding]; other site
653733001796	active site
653733001797	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
653733001798	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
653733001799	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
653733001800	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
653733001801	dimer interface [polypeptide binding]; other site
653733001802	active site
653733001803	CoA binding pocket [chemical binding]; other site
653733001804	putative phosphate acyltransferase; Provisional; Region: PRK05331
653733001805	50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286
653733001806	sensor protein ZraS; Provisional; Region: PRK10364
653733001807	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
653733001808	dimer interface [polypeptide binding]; other site
653733001809	phosphorylation site [posttranslational modification]
653733001810	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
653733001811	ATP binding site [chemical binding]; other site
653733001812	Mg2+ binding site [ion binding]; other site
653733001813	G-X-G motif; other site
653733001814	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
653733001815	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
653733001816	active site
653733001817	phosphorylation site [posttranslational modification]
653733001818	intermolecular recognition site; other site
653733001819	dimerization interface [polypeptide binding]; other site
653733001820	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
653733001821	Walker A motif; other site
653733001822	ATP binding site [chemical binding]; other site
653733001823	Walker B motif; other site
653733001824	arginine finger; other site
653733001825	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
653733001826	Major Facilitator Superfamily; Region: MFS_1; pfam07690
653733001827	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
653733001828	putative substrate translocation pore; other site
653733001829	HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662
653733001830	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
653733001831	active site
653733001832	motif I; other site
653733001833	motif II; other site
653733001834	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
653733001835	Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835
653733001836	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5375
653733001837	lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002
653733001838	OstA-like protein; Region: OstA; cl00844
653733001839	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
653733001840	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
653733001841	Walker A/P-loop; other site
653733001842	ATP binding site [chemical binding]; other site
653733001843	Q-loop/lid; other site
653733001844	ABC transporter signature motif; other site
653733001845	Walker B; other site
653733001846	D-loop; other site
653733001847	H-loop/switch region; other site
653733001848	RNA polymerase factor sigma-54; Reviewed; Region: PRK05932
653733001849	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
653733001850	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
653733001851	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
653733001852	30S subunit binding site; other site
653733001853	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
653733001854	active site
653733001855	phosphorylation site [posttranslational modification]
653733001856	Protein of unknown function (DUF996); Region: DUF996; cl00970
653733001857	Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591
653733001858	Na binding site [ion binding]; other site
653733001859	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
653733001860	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
653733001861	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
653733001862	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
653733001863	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
653733001864	anti sigma factor interaction site; other site
653733001865	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
653733001866	regulatory phosphorylation site [posttranslational modification]; other site
653733001867	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
653733001868	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
653733001869	ATP binding site [chemical binding]; other site
653733001870	Mg2+ binding site [ion binding]; other site
653733001871	G-X-G motif; other site
653733001872	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
653733001873	intersubunit interface [polypeptide binding]; other site
653733001874	active site
653733001875	zinc binding site [ion binding]; other site
653733001876	Na+ binding site [ion binding]; other site
653733001877	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
653733001878	catalytic residues [active]
653733001879	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
653733001880	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
653733001881	NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602
653733001882	NADH dehydrogenase subunit B; Validated; Region: PRK06411
653733001883	Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917
653733001884	NADH dehydrogenase subunit D; Validated; Region: PRK06075
653733001885	NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649
653733001886	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
653733001887	NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971
653733001888	4Fe-4S binding domain; Region: Fer4; pfam00037
653733001889	4Fe-4S binding domain; Region: Fer4; pfam00037
653733001890	NADH dehydrogenase subunit J; Provisional; Region: PRK06433
653733001891	NADH:ubiquinone oxidoreductase subunit 6 (chain J) [Energy production and conversion]; Region: NuoJ; COG0839
653733001892	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
653733001893	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
653733001894	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
653733001895	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
653733001896	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
653733001897	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
653733001898	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
653733001899	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
653733001900	HAMP domain; Region: HAMP; pfam00672
653733001901	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
653733001902	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
653733001903	dimer interface [polypeptide binding]; other site
653733001904	putative CheW interface [polypeptide binding]; other site
653733001905	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
653733001906	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
653733001907	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
653733001908	active site
653733001909	phosphorylation site [posttranslational modification]
653733001910	intermolecular recognition site; other site
653733001911	dimerization interface [polypeptide binding]; other site
653733001912	DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566
653733001913	HDOD domain; Region: HDOD; pfam08668
653733001914	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; smart00471
653733001915	GAF domain; Region: GAF_3; pfam13492
653733001916	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
653733001917	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
653733001918	dimer interface [polypeptide binding]; other site
653733001919	phosphorylation site [posttranslational modification]
653733001920	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
653733001921	ATP binding site [chemical binding]; other site
653733001922	Mg2+ binding site [ion binding]; other site
653733001923	G-X-G motif; other site
653733001924	Response regulator receiver domain; Region: Response_reg; pfam00072
653733001925	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
653733001926	active site
653733001927	phosphorylation site [posttranslational modification]
653733001928	intermolecular recognition site; other site
653733001929	dimerization interface [polypeptide binding]; other site
653733001930	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086
653733001931	Response regulator receiver domain; Region: Response_reg; pfam00072
653733001932	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
653733001933	active site
653733001934	phosphorylation site [posttranslational modification]
653733001935	intermolecular recognition site; other site
653733001936	dimerization interface [polypeptide binding]; other site
653733001937	Response regulator receiver domain; Region: Response_reg; pfam00072
653733001938	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
653733001939	active site
653733001940	phosphorylation site [posttranslational modification]
653733001941	intermolecular recognition site; other site
653733001942	dimerization interface [polypeptide binding]; other site
653733001943	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
653733001944	PAS fold; Region: PAS_3; pfam08447
653733001945	putative active site [active]
653733001946	heme pocket [chemical binding]; other site
653733001947	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
653733001948	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
653733001949	PAS domain; Region: PAS_9; pfam13426
653733001950	putative active site [active]
653733001951	heme pocket [chemical binding]; other site
653733001952	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
653733001953	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
653733001954	metal binding site [ion binding]; metal-binding site
653733001955	active site
653733001956	I-site; other site
653733001957	Uncharacterized conserved protein [Function unknown]; Region: COG3268
653733001958	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
653733001959	NAD(P) binding site [chemical binding]; other site
653733001960	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
653733001961	Sel1-like repeats; Region: SEL1; smart00671
653733001962	Sel1-like repeats; Region: SEL1; smart00671
653733001963	Methyltransferase domain; Region: Methyltransf_23; pfam13489
653733001964	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
653733001965	S-adenosylmethionine binding site [chemical binding]; other site
653733001966	Cache domain; Region: Cache_1; pfam02743
653733001967	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
653733001968	dimerization interface [polypeptide binding]; other site
653733001969	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
653733001970	dimer interface [polypeptide binding]; other site
653733001971	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
653733001972	putative CheW interface [polypeptide binding]; other site
653733001973	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
653733001974	Response regulator receiver domain; Region: Response_reg; pfam00072
653733001975	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
653733001976	active site
653733001977	phosphorylation site [posttranslational modification]
653733001978	intermolecular recognition site; other site
653733001979	dimerization interface [polypeptide binding]; other site
653733001980	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120
653733001981	Transglycosylase SLT domain; Region: SLT_2; pfam13406
653733001982	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361
653733001983	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
653733001984	N-acetyl-D-glucosamine binding site [chemical binding]; other site
653733001985	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
653733001986	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
653733001987	aspartate aminotransferase; Provisional; Region: PRK05764
653733001988	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
653733001989	pyridoxal 5'-phosphate binding site [chemical binding]; other site
653733001990	homodimer interface [polypeptide binding]; other site
653733001991	catalytic residue [active]
653733001992	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
653733001993	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
653733001994	active site
653733001995	(T/H)XGH motif; other site
653733001996	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
653733001997	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
653733001998	S-adenosylmethionine binding site [chemical binding]; other site
653733001999	Maf-like protein; Region: Maf; pfam02545
653733002000	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
653733002001	active site
653733002002	dimer interface [polypeptide binding]; other site
653733002003	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
653733002004	anti sigma factor interaction site; other site
653733002005	regulatory phosphorylation site [posttranslational modification]; other site
653733002006	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
653733002007	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
653733002008	substrate binding pocket [chemical binding]; other site
653733002009	chain length determination region; other site
653733002010	substrate-Mg2+ binding site; other site
653733002011	catalytic residues [active]
653733002012	aspartate-rich region 1; other site
653733002013	active site lid residues [active]
653733002014	aspartate-rich region 2; other site
653733002015	hybrid cluster protein-associated redox disulfide domain; Region: prismane_assoc; TIGR03980
653733002016	zinc transporter ZupT; Provisional; Region: PRK04201
653733002017	ZIP Zinc transporter; Region: Zip; pfam02535
653733002018	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
653733002019	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
653733002020	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
653733002021	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
653733002022	RNA binding site [nucleotide binding]; other site
653733002023	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
653733002024	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
653733002025	catalytic triad [active]
653733002026	Predicted permeases [General function prediction only]; Region: COG0679
653733002027	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179
653733002028	Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755
653733002029	putative ATP binding site [chemical binding]; other site
653733002030	putative substrate interface [chemical binding]; other site
653733002031	apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302
653733002032	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
653733002033	putative active site [active]
653733002034	catalytic triad [active]
653733002035	putative dimer interface [polypeptide binding]; other site
653733002036	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
653733002037	putative substrate translocation pore; other site
653733002038	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
653733002039	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
653733002040	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
653733002041	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
653733002042	dimer interface [polypeptide binding]; other site
653733002043	ssDNA binding site [nucleotide binding]; other site
653733002044	tetramer (dimer of dimers) interface [polypeptide binding]; other site
653733002045	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
653733002046	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
653733002047	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
653733002048	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
653733002049	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
653733002050	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
653733002051	FAD binding domain; Region: FAD_binding_4; pfam01565
653733002052	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
653733002053	LabA_like proteins; Region: LabA; cd10911
653733002054	Uncharacterized conserved protein [Function unknown]; Region: COG1432
653733002055	putative metal binding site [ion binding]; other site
653733002056	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096
653733002057	Protein of unknown function (DUF3696); Region: DUF3696; pfam12476
653733002058	Adenylation domain of proteins similar to ATP-dependent polynucleotide ligases; Region: Adenylation_DNA_ligase_like; cl12015
653733002059	active site
653733002060	AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287
653733002061	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
653733002062	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
653733002063	ATP binding site [chemical binding]; other site
653733002064	putative Mg++ binding site [ion binding]; other site
653733002065	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
653733002066	nucleotide binding region [chemical binding]; other site
653733002067	ATP-binding site [chemical binding]; other site
653733002068	Domain of unknown function (DU1801); Region: DUF1801; pfam08818
653733002069	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
653733002070	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990
653733002071	putative acyl-acceptor binding pocket; other site
653733002072	Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467
653733002073	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
653733002074	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
653733002075	active site
653733002076	catalytic site [active]
653733002077	substrate binding site [chemical binding]; other site
653733002078	Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905
653733002079	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
653733002080	ligand binding site [chemical binding]; other site
653733002081	flexible hinge region; other site
653733002082	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800
653733002083	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
653733002084	metal binding triad; other site
653733002085	BCCT family transporter; Region: BCCT; pfam02028
653733002086	Autoinducer binding domain; Region: Autoind_bind; pfam03472
653733002087	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
653733002088	DNA binding residues [nucleotide binding]
653733002089	dimerization interface [polypeptide binding]; other site
653733002090	indolepyruvate oxidoreductase subunit beta; Reviewed; Region: PRK06853
653733002091	2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537
653733002092	indolepyruvate ferredoxin oxidoreductase, alpha subunit; Region: IOR_alpha; TIGR03336
653733002093	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
653733002094	dimer interface [polypeptide binding]; other site
653733002095	PYR/PP interface [polypeptide binding]; other site
653733002096	TPP binding site [chemical binding]; other site
653733002097	substrate binding site [chemical binding]; other site
653733002098	Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008
653733002099	TPP-binding site; other site
653733002100	4Fe-4S binding domain; Region: Fer4; pfam00037
653733002101	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
653733002102	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
653733002103	catalytic residues [active]
653733002104	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
653733002105	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
653733002106	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
653733002107	ligand binding site [chemical binding]; other site
653733002108	active site
653733002109	UGI interface [polypeptide binding]; other site
653733002110	catalytic site [active]
653733002111	Uncharacterized conserved protein [Function unknown]; Region: COG1739
653733002112	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
653733002113	Fic family protein [Function unknown]; Region: COG3177
653733002114	Domain of unknown function (DUF4172); Region: DUF4172; pfam13776
653733002115	Fic/DOC family; Region: Fic; pfam02661
653733002116	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
653733002117	dimer interface [polypeptide binding]; other site
653733002118	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
653733002119	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
653733002120	dimer interface [polypeptide binding]; other site
653733002121	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
653733002122	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
653733002123	Coenzyme A binding pocket [chemical binding]; other site
653733002124	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393
653733002125	putative DNA-binding transcriptional regulator; Provisional; Region: PRK09775
653733002126	DNA-binding interface [nucleotide binding]; DNA binding site
653733002127	HipA-like N-terminal domain; Region: HipA_N; pfam07805
653733002128	HipA-like C-terminal domain; Region: HipA_C; pfam07804
653733002129	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
653733002130	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
653733002131	non-specific DNA binding site [nucleotide binding]; other site
653733002132	salt bridge; other site
653733002133	sequence-specific DNA binding site [nucleotide binding]; other site
653733002134	nitrogenase reductase; Reviewed; Region: nifH; PRK13234
653733002135	NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040
653733002136	Nucleotide-binding sites [chemical binding]; other site
653733002137	Walker A motif; other site
653733002138	Switch I region of nucleotide binding site; other site
653733002139	Fe4S4 binding sites [ion binding]; other site
653733002140	Switch II region of nucleotide binding site; other site
653733002141	Nitrogenase molybdenum-iron protein, alpha and beta chains [Energy production and conversion]; Region: NifD; COG2710
653733002142	Nitrogenase_MoFe_alpha_II: Nitrogenase MoFe protein, beta subunit. A group of proteins similar to the alpha subunit of the MoFe protein of the molybdenum (Mo-) nitrogenase. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to...; Region: Nitrogenase_MoFe_alpha; cd01976
653733002143	MoFe protein alpha/beta subunit interactions; other site
653733002144	Alpha subunit P cluster binding residues; other site
653733002145	FeMoco binding residues [chemical binding]; other site
653733002146	MoFe protein alpha subunit/Fe protein contacts; other site
653733002147	MoFe protein dimer/ dimer interactions; other site
653733002148	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
653733002149	Transposase; Region: HTH_Tnp_1; pfam01527
653733002150	putative transposase OrfB; Reviewed; Region: PHA02517
653733002151	HTH-like domain; Region: HTH_21; pfam13276
653733002152	Integrase core domain; Region: rve; pfam00665
653733002153	Integrase core domain; Region: rve_3; pfam13683
653733002154	NifT/FixU protein; Region: NifT; pfam06988
653733002155	ketol-acid reductoisomerase; Provisional; Region: PRK05479
653733002156	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
653733002157	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
653733002158	L-aspartate oxidase; Provisional; Region: PRK09077
653733002159	L-aspartate oxidase; Provisional; Region: PRK06175
653733002160	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
653733002161	Superoxide reductase-like (SORL) domain; present in a family of mononuclear non-heme iron proteins that includes superoxide reductase and desulfoferrodoxin. Superoxide reductase-like proteins scavenge superoxide anion radicals as a defense mechanism...; Region: SORL; cl00014
653733002162	non-heme iron binding site [ion binding]; other site
653733002163	Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787
653733002164	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
653733002165	active site
653733002166	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
653733002167	dimer interface [polypeptide binding]; other site
653733002168	substrate binding site [chemical binding]; other site
653733002169	catalytic residues [active]
653733002170	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
653733002171	Permease; Region: Permease; pfam02405
653733002172	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
653733002173	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
653733002174	Walker A/P-loop; other site
653733002175	ATP binding site [chemical binding]; other site
653733002176	Q-loop/lid; other site
653733002177	ABC transporter signature motif; other site
653733002178	Walker B; other site
653733002179	D-loop; other site
653733002180	H-loop/switch region; other site
653733002181	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
653733002182	mce related protein; Region: MCE; pfam02470
653733002183	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
653733002184	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
653733002185	HlyD family secretion protein; Region: HlyD_3; pfam13437
653733002186	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
653733002187	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
653733002188	FtsX-like permease family; Region: FtsX; pfam02687
653733002189	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
653733002190	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
653733002191	FtsX-like permease family; Region: FtsX; pfam02687
653733002192	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
653733002193	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
653733002194	Walker A/P-loop; other site
653733002195	ATP binding site [chemical binding]; other site
653733002196	Q-loop/lid; other site
653733002197	ABC transporter signature motif; other site
653733002198	Walker B; other site
653733002199	D-loop; other site
653733002200	H-loop/switch region; other site
653733002201	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
653733002202	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
653733002203	active site
653733002204	DNA binding site [nucleotide binding]
653733002205	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
653733002206	Major Facilitator Superfamily; Region: MFS_1; pfam07690
653733002207	putative substrate translocation pore; other site
653733002208	Cache domain; Region: Cache_1; pfam02743
653733002209	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
653733002210	PAS fold; Region: PAS_3; pfam08447
653733002211	putative active site [active]
653733002212	heme pocket [chemical binding]; other site
653733002213	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
653733002214	putative active site [active]
653733002215	heme pocket [chemical binding]; other site
653733002216	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
653733002217	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
653733002218	ATP binding site [chemical binding]; other site
653733002219	Mg2+ binding site [ion binding]; other site
653733002220	G-X-G motif; other site
653733002221	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
653733002222	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
653733002223	FeS/SAM binding site; other site
653733002224	Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762
653733002225	serine O-acetyltransferase; Region: cysE; TIGR01172
653733002226	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
653733002227	trimer interface [polypeptide binding]; other site
653733002228	active site
653733002229	substrate binding site [chemical binding]; other site
653733002230	CoA binding site [chemical binding]; other site
653733002231	Fe-S cluster assembly protein NifU; Region: NifU_proper; TIGR02000
653733002232	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
653733002233	trimerization site [polypeptide binding]; other site
653733002234	active site
653733002235	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
653733002236	Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694
653733002237	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
653733002238	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
653733002239	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
653733002240	catalytic residue [active]
653733002241	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
653733002242	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
653733002243	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
653733002244	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
653733002245	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
653733002246	inhibitor-cofactor binding pocket; inhibition site
653733002247	pyridoxal 5'-phosphate binding site [chemical binding]; other site
653733002248	catalytic residue [active]
653733002249	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
653733002250	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
653733002251	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
653733002252	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
653733002253	N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) [Cell envelope biogenesis, outer membrane]; Region: GlmU; COG1207
653733002254	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
653733002255	Substrate binding site; other site
653733002256	Mg++ binding site; other site
653733002257	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
653733002258	active site
653733002259	substrate binding site [chemical binding]; other site
653733002260	CoA binding site [chemical binding]; other site
653733002261	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
653733002262	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
653733002263	motif 1; other site
653733002264	active site
653733002265	motif 2; other site
653733002266	motif 3; other site
653733002267	D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; cl17802
653733002268	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
653733002269	DHHA1 domain; Region: DHHA1; pfam02272
653733002270	Chorismate mutase type II; Region: CM_2; pfam01817
653733002271	Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077
653733002272	Prephenate dehydratase; Region: PDT; pfam00800
653733002273	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
653733002274	putative L-Phe binding site [chemical binding]; other site
653733002275	histidinol-phosphate aminotransferase; Validated; Region: PRK02731
653733002276	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
653733002277	pyridoxal 5'-phosphate binding site [chemical binding]; other site
653733002278	homodimer interface [polypeptide binding]; other site
653733002279	catalytic residue [active]
653733002280	Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287
653733002281	prephenate dehydrogenase; Validated; Region: PRK08507
653733002282	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
653733002283	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
653733002284	hinge; other site
653733002285	active site
653733002286	cytidylate kinase; Provisional; Region: cmk; PRK00023
653733002287	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
653733002288	CMP-binding site; other site
653733002289	The sites determining sugar specificity; other site
653733002290	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
653733002291	(E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216
653733002292	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299
653733002293	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
653733002294	RNA binding site [nucleotide binding]; other site
653733002295	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
653733002296	RNA binding site [nucleotide binding]; other site
653733002297	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
653733002298	RNA binding site [nucleotide binding]; other site
653733002299	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
653733002300	RNA binding site [nucleotide binding]; other site
653733002301	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
653733002302	RNA binding site [nucleotide binding]; other site
653733002303	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
653733002304	RNA binding site [nucleotide binding]; other site
653733002305	Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465
653733002306	Replicase polyprotein 1ab; Region: Nsp3; pfam11633
653733002307	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
653733002308	Flagellin-specific chaperone FliS [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliS; COG1516
653733002309	Putative motility protein; Region: YjfB_motility; pfam14070
653733002310	PAS domain; Region: PAS_9; pfam13426
653733002311	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
653733002312	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
653733002313	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
653733002314	anti sigma factor interaction site; other site
653733002315	regulatory phosphorylation site [posttranslational modification]; other site
653733002316	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
653733002317	anti sigma factor interaction site; other site
653733002318	regulatory phosphorylation site [posttranslational modification]; other site
653733002319	HEAT repeats; Region: HEAT_2; pfam13646
653733002320	HEAT repeats; Region: HEAT_2; pfam13646
653733002321	E-Z type HEAT repeats; Region: EZ_HEAT; smart00567
653733002322	HEAT repeats; Region: HEAT_2; pfam13646
653733002323	HEAT repeats; Region: HEAT_2; pfam13646
653733002324	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
653733002325	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
653733002326	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
653733002327	ankyrin repeat protein; Provisional; Region: PHA02875
653733002328	GTP-binding protein YchF; Reviewed; Region: PRK09601
653733002329	YchF GTPase; Region: YchF; cd01900
653733002330	G1 box; other site
653733002331	GTP/Mg2+ binding site [chemical binding]; other site
653733002332	Switch I region; other site
653733002333	G2 box; other site
653733002334	Switch II region; other site
653733002335	G3 box; other site
653733002336	G4 box; other site
653733002337	G5 box; other site
653733002338	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
653733002339	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
653733002340	feedback inhibition sensing region; other site
653733002341	homohexameric interface [polypeptide binding]; other site
653733002342	nucleotide binding site [chemical binding]; other site
653733002343	N-acetyl-L-glutamate binding site [chemical binding]; other site
653733002344	DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939
653733002345	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
653733002346	ATP binding site [chemical binding]; other site
653733002347	Mg2+ binding site [ion binding]; other site
653733002348	G-X-G motif; other site
653733002349	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
653733002350	anchoring element; other site
653733002351	dimer interface [polypeptide binding]; other site
653733002352	ATP binding site [chemical binding]; other site
653733002353	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
653733002354	active site
653733002355	putative metal-binding site [ion binding]; other site
653733002356	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
653733002357	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
653733002358	oligomerisation interface [polypeptide binding]; other site
653733002359	mobile loop; other site
653733002360	roof hairpin; other site
653733002361	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
653733002362	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
653733002363	ring oligomerisation interface [polypeptide binding]; other site
653733002364	ATP/Mg binding site [chemical binding]; other site
653733002365	stacking interactions; other site
653733002366	hinge regions; other site
653733002367	Protein of unknown function (DUF1538); Region: DUF1538; pfam07556
653733002368	Protein of unknown function (DUF1538); Region: DUF1538; pfam07556
653733002369	Nitrogen regulatory protein P-II; Region: P-II; smart00938
653733002370	Nitrogen regulatory protein P-II; Region: P-II; smart00938
653733002371	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
653733002372	dimerization interface [polypeptide binding]; other site
653733002373	putative DNA binding site [nucleotide binding]; other site
653733002374	putative Zn2+ binding site [ion binding]; other site
653733002375	ferredoxin-type protein, NapH/MauN family; Region: napH_; TIGR02163
653733002376	4Fe-4S binding domain; Region: Fer4_5; pfam12801
653733002377	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
653733002378	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
653733002379	4Fe-4S binding domain; Region: Fer4; pfam00037
653733002380	NapD protein; Region: NapD; cl01163
653733002381	nitrate reductase catalytic subunit; Provisional; Region: PRK13532
653733002382	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
653733002383	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
653733002384	molybdopterin cofactor binding site; other site
653733002385	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791
653733002386	molybdopterin cofactor binding site; other site
653733002387	Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cl03439
653733002388	heme-binding residues [chemical binding]; other site
653733002389	Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527
653733002390	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
653733002391	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
653733002392	ATP synthase subunit C; Region: ATP-synt_C; cl00466
653733002393	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
653733002394	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
653733002395	FMN binding site [chemical binding]; other site
653733002396	substrate binding site [chemical binding]; other site
653733002397	putative catalytic residue [active]
653733002398	succinyldiaminopimelate transaminase; Region: DapC; TIGR03537
653733002399	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
653733002400	pyridoxal 5'-phosphate binding site [chemical binding]; other site
653733002401	homodimer interface [polypeptide binding]; other site
653733002402	catalytic residue [active]
653733002403	2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830
653733002404	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
653733002405	trimer interface [polypeptide binding]; other site
653733002406	active site
653733002407	substrate binding site [chemical binding]; other site
653733002408	CoA binding site [chemical binding]; other site
653733002409	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
653733002410	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
653733002411	DNA binding site [nucleotide binding]
653733002412	Glutamine amidotransferases class-II (Gn-AT)_GlxB-type.  GlxB is a glutamine amidotransferase-like protein of unknown function found in bacteria and archaea. GlxB has a structural fold similar to that of other class II glutamine amidotransferases...; Region: GlxB; cd01907
653733002413	putative active site [active]
653733002414	4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484
653733002415	4Fe-4S binding domain; Region: Fer4; pfam00037
653733002416	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
653733002417	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
653733002418	Conserved region in glutamate synthase; Region: Glu_synthase; pfam01645
653733002419	active site
653733002420	FMN binding site [chemical binding]; other site
653733002421	substrate binding site [chemical binding]; other site
653733002422	3Fe-4S cluster binding site [ion binding]; other site
653733002423	GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS),  in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cl00239
653733002424	domain_subunit interface; other site
653733002425	putative glutamate synthase (NADPH) small subunit; Provisional; Region: PRK12771
653733002426	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
653733002427	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
653733002428	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
653733002429	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
653733002430	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
653733002431	Cl- selectivity filter; other site
653733002432	Cl- binding residues [ion binding]; other site
653733002433	pore gating glutamate residue; other site
653733002434	dimer interface [polypeptide binding]; other site
653733002435	FOG: CBS domain [General function prediction only]; Region: COG0517
653733002436	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc2; cd04613
653733002437	Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658
653733002438	Competence protein; Region: Competence; pfam03772
653733002439	TPR repeat; Region: TPR_11; pfam13414
653733002440	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
653733002441	binding surface
653733002442	TPR motif; other site
653733002443	TPR repeat; Region: TPR_11; pfam13414
653733002444	Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820
653733002445	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
653733002446	FeS/SAM binding site; other site
653733002447	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
653733002448	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
653733002449	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
653733002450	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
653733002451	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
653733002452	generic binding surface II; other site
653733002453	generic binding surface I; other site
653733002454	protoporphyrinogen oxidase; Reviewed; Region: PRK11883
653733002455	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
653733002456	ferrochelatase; Reviewed; Region: hemH; PRK00035
653733002457	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
653733002458	C-terminal domain interface [polypeptide binding]; other site
653733002459	active site
653733002460	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
653733002461	active site
653733002462	N-terminal domain interface [polypeptide binding]; other site
653733002463	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
653733002464	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
653733002465	glutaminase active site [active]
653733002466	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
653733002467	dimer interface [polypeptide binding]; other site
653733002468	active site
653733002469	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
653733002470	dimer interface [polypeptide binding]; other site
653733002471	active site
653733002472	Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550
653733002473	succinate CoA transferase; Region: YgfH_subfam; TIGR03458
653733002474	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
653733002475	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
653733002476	Predicted amidohydrolase [General function prediction only]; Region: COG0388
653733002477	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424
653733002478	active site
653733002479	catalytic triad [active]
653733002480	dimer interface [polypeptide binding]; other site
653733002481	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
653733002482	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
653733002483	aconitate hydratase; Validated; Region: PRK09277
653733002484	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
653733002485	substrate binding site [chemical binding]; other site
653733002486	ligand binding site [chemical binding]; other site
653733002487	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
653733002488	substrate binding site [chemical binding]; other site
653733002489	Cytochrome b5-like Heme/Steroid binding domain; Region: Cyt-b5; cl02041
653733002490	Predicted membrane protein (DUF2231); Region: DUF2231; cl01730
653733002491	pyruvate phosphate dikinase; Provisional; Region: PRK09279
653733002492	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
653733002493	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
653733002494	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
653733002495	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
653733002496	tRNA pseudouridine isomerase C; Region: PseudoU_synth_TruC; cd02563
653733002497	probable active site [active]
653733002498	PAS domain; Region: PAS_9; pfam13426
653733002499	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
653733002500	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
653733002501	ATP binding site [chemical binding]; other site
653733002502	Mg2+ binding site [ion binding]; other site
653733002503	G-X-G motif; other site
653733002504	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
653733002505	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
653733002506	Coenzyme A binding pocket [chemical binding]; other site
653733002507	Peptidase_C39 like family; Region: DUF3335; pfam11814
653733002508	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
653733002509	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
653733002510	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
653733002511	DHH family; Region: DHH; pfam01368
653733002512	DHHA1 domain; Region: DHHA1; pfam02272
653733002513	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
653733002514	Glycoprotease family; Region: Peptidase_M22; pfam00814
653733002515	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
653733002516	Coenzyme A binding pocket [chemical binding]; other site
653733002517	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
653733002518	Transposase; Region: HTH_Tnp_1; pfam01527
653733002519	putative transposase OrfB; Reviewed; Region: PHA02517
653733002520	HTH-like domain; Region: HTH_21; pfam13276
653733002521	Integrase core domain; Region: rve; pfam00665
653733002522	Integrase core domain; Region: rve_3; pfam13683
653733002523	Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542
653733002524	Transposase; Region: DDE_Tnp_ISL3; pfam01610
653733002525	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
653733002526	Transposase; Region: HTH_Tnp_1; pfam01527
653733002527	putative transposase OrfB; Reviewed; Region: PHA02517
653733002528	HTH-like domain; Region: HTH_21; pfam13276
653733002529	Integrase core domain; Region: rve; pfam00665
653733002530	Integrase core domain; Region: rve_3; pfam13683
653733002531	recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409
653733002532	MutS domain III; Region: MutS_III; pfam05192
653733002533	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
653733002534	Walker A/P-loop; other site
653733002535	ATP binding site [chemical binding]; other site
653733002536	Q-loop/lid; other site
653733002537	ABC transporter signature motif; other site
653733002538	Walker B; other site
653733002539	D-loop; other site
653733002540	H-loop/switch region; other site
653733002541	Smr domain; Region: Smr; pfam01713
653733002542	Tim44-like domain; Region: Tim44; cl09208
653733002543	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
653733002544	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
653733002545	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
653733002546	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
653733002547	Sporulation related domain; Region: SPOR; pfam05036
653733002548	uracil-xanthine permease; Region: ncs2; TIGR00801
653733002549	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
653733002550	active site
653733002551	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
653733002552	dimer interface [polypeptide binding]; other site
653733002553	active site
653733002554	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
653733002555	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
653733002556	catalytic residues [active]
653733002557	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
653733002558	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
653733002559	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
653733002560	TrkA-N domain; Region: TrkA_N; pfam02254
653733002561	TrkA-C domain; Region: TrkA_C; pfam02080
653733002562	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
653733002563	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562
653733002564	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
653733002565	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
653733002566	Protein of unknown function (DUF342); Region: DUF342; pfam03961
653733002567	Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519
653733002568	Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434
653733002569	EAL domain; Region: EAL; pfam00563
653733002570	Bacteriophage CI repressor helix-turn-helix domain; Region: Phage_CI_repr; pfam07022
653733002571	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
653733002572	Predicted transcriptional regulator [Transcription]; Region: COG2932
653733002573	Catalytic site [active]
653733002574	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
653733002575	Response regulator receiver domain; Region: Response_reg; pfam00072
653733002576	active site
653733002577	phosphorylation site [posttranslational modification]
653733002578	intermolecular recognition site; other site
653733002579	dimerization interface [polypeptide binding]; other site
653733002580	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
653733002581	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
653733002582	dimer interface [polypeptide binding]; other site
653733002583	phosphorylation site [posttranslational modification]
653733002584	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
653733002585	ATP binding site [chemical binding]; other site
653733002586	Mg2+ binding site [ion binding]; other site
653733002587	G-X-G motif; other site
653733002588	homoserine dehydrogenase; Provisional; Region: PRK06349
653733002589	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
653733002590	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
653733002591	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
653733002592	threonine synthase; Reviewed; Region: PRK06721
653733002593	Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of  threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563
653733002594	homodimer interface [polypeptide binding]; other site
653733002595	pyridoxal 5'-phosphate binding site [chemical binding]; other site
653733002596	catalytic residue [active]
653733002597	2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: PhosphMutase; cl17294
653733002598	cofactor-independent phosphoglycerate mutase; Provisional; Region: PRK04200
653733002599	aspartate kinase; Reviewed; Region: PRK06635
653733002600	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
653733002601	putative nucleotide binding site [chemical binding]; other site
653733002602	putative catalytic residues [active]
653733002603	putative Mg ion binding site [ion binding]; other site
653733002604	putative aspartate binding site [chemical binding]; other site
653733002605	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
653733002606	putative allosteric regulatory site; other site
653733002607	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
653733002608	putative allosteric regulatory residue; other site
653733002609	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
653733002610	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
653733002611	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
653733002612	Transcriptional regulator [Transcription]; Region: IclR; COG1414
653733002613	Bacterial transcriptional regulator; Region: IclR; pfam01614
653733002614	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
653733002615	active site
653733002616	intersubunit interactions; other site
653733002617	catalytic residue [active]
653733002618	Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847
653733002619	jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation.  The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414
653733002620	G-X-X-G motif; other site
653733002621	R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644
653733002622	RxxxH motif; other site
653733002623	membrane protein insertase; Provisional; Region: PRK01318
653733002624	aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648
653733002625	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
653733002626	Haemolytic domain; Region: Haemolytic; pfam01809
653733002627	Ribonuclease P; Region: Ribonuclease_P; cl00457
653733002628	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399
653733002629	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
653733002630	Domain of unknown function DUF77; Region: DUF77; pfam01910
653733002631	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
653733002632	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
653733002633	dimer interface [polypeptide binding]; other site
653733002634	anticodon binding site; other site
653733002635	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
653733002636	homodimer interface [polypeptide binding]; other site
653733002637	motif 1; other site
653733002638	active site
653733002639	motif 2; other site
653733002640	GAD domain; Region: GAD; pfam02938
653733002641	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
653733002642	motif 3; other site
653733002643	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
653733002644	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
653733002645	dimer interface [polypeptide binding]; other site
653733002646	motif 1; other site
653733002647	active site
653733002648	motif 2; other site
653733002649	motif 3; other site
653733002650	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
653733002651	anticodon binding site; other site
653733002652	Putative exonuclease, RdgC; Region: RdgC; cl01122
653733002653	Domain of unknown function DUF59; Region: DUF59; pfam01883
653733002654	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
653733002655	Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139
653733002656	Short C-terminal domain; Region: SHOCT; pfam09851
653733002657	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
653733002658	active site
653733002659	dimer interface [polypeptide binding]; other site
653733002660	Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600
653733002661	Uncharacterized conserved protein [Function unknown]; Region: COG1430
653733002662	Protein of unknown function (DUF3365); Region: DUF3365; pfam11845
653733002663	PAS domain S-box; Region: sensory_box; TIGR00229
653733002664	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
653733002665	putative active site [active]
653733002666	heme pocket [chemical binding]; other site
653733002667	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
653733002668	ATP binding site [chemical binding]; other site
653733002669	Mg2+ binding site [ion binding]; other site
653733002670	G-X-G motif; other site
653733002671	methionine sulfoxide reductase A; Provisional; Region: PRK14054
653733002672	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
653733002673	HSP70 interaction site [polypeptide binding]; other site
653733002674	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
653733002675	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
653733002676	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
653733002677	Walker A/P-loop; other site
653733002678	ATP binding site [chemical binding]; other site
653733002679	Q-loop/lid; other site
653733002680	ABC transporter signature motif; other site
653733002681	Walker B; other site
653733002682	D-loop; other site
653733002683	H-loop/switch region; other site
653733002684	Flagellar basal body-associated protein FliL; Region: FliL; cl00681
653733002685	putative transporter; Provisional; Region: PRK11660
653733002686	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
653733002687	Sulfate transporter family; Region: Sulfate_transp; pfam00916
653733002688	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
653733002689	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
653733002690	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
653733002691	ligand binding site [chemical binding]; other site
653733002692	flexible hinge region; other site
653733002693	Ferredoxin [Energy production and conversion]; Region: Fer; COG1141
653733002694	Protein of unknown function (DUF1271); Region: DUF1271; cl01443
653733002695	Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049
653733002696	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
653733002697	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
653733002698	dimer interface [polypeptide binding]; other site
653733002699	putative CheW interface [polypeptide binding]; other site
653733002700	GTP cyclohydrolase I; Provisional; Region: folE; PRK09347
653733002701	GTP cyclohydrolase I; Provisional; Region: PLN03044
653733002702	active site
653733002703	3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749
653733002704	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
653733002705	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
653733002706	Cell division protein FtsA; Region: FtsA; cl17206
653733002707	Competence protein A; Region: Competence_A; pfam11104
653733002708	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
653733002709	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
653733002710	[Protein-PII] uridylyltransferase; Region: UTase_glnD; TIGR01693
653733002711	metal binding triad; other site
653733002712	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
653733002713	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
653733002714	Zn2+ binding site [ion binding]; other site
653733002715	Mg2+ binding site [ion binding]; other site
653733002716	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
653733002717	C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899
653733002718	Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088
653733002719	Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; smart00839
653733002720	Protein of unknown function (DUF3365); Region: DUF3365; pfam11845
653733002721	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
653733002722	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
653733002723	dimer interface [polypeptide binding]; other site
653733002724	phosphorylation site [posttranslational modification]
653733002725	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
653733002726	ATP binding site [chemical binding]; other site
653733002727	Mg2+ binding site [ion binding]; other site
653733002728	G-X-G motif; other site
653733002729	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2604
653733002730	biotin synthase; Validated; Region: PRK06256
653733002731	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
653733002732	FeS/SAM binding site; other site
653733002733	Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968
653733002734	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
653733002735	Protein export membrane protein; Region: SecD_SecF; cl14618
653733002736	Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845
653733002737	HlyD family secretion protein; Region: HlyD_3; pfam13437
653733002738	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
653733002739	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
653733002740	dimer interface [polypeptide binding]; other site
653733002741	decamer (pentamer of dimers) interface [polypeptide binding]; other site
653733002742	catalytic triad [active]
653733002743	peroxidatic and resolving cysteines [active]
653733002744	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
653733002745	Signal transduction protein containing GAF and PtsI domains [Signal transduction mechanisms]; Region: PtsP; COG3605
653733002746	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
653733002747	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
653733002748	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
653733002749	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
653733002750	Queuosine biosynthesis protein; Region: Queuosine_synth; pfam02547
653733002751	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
653733002752	phosphofructokinase; Region: PFK_mixed; TIGR02483
653733002753	active site
653733002754	ADP/pyrophosphate binding site [chemical binding]; other site
653733002755	dimerization interface [polypeptide binding]; other site
653733002756	allosteric effector site; other site
653733002757	fructose-1,6-bisphosphate binding site; other site
653733002758	glutamate dehydrogenase; Provisional; Region: PRK09414
653733002759	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
653733002760	NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313
653733002761	NAD(P) binding site [chemical binding]; other site
653733002762	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
653733002763	cAMP phosphodiesterases class-II; Region: PDEase_II; cl17776
653733002764	leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301
653733002765	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
653733002766	Peptidase family M23; Region: Peptidase_M23; pfam01551
653733002767	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2604
653733002768	pseudaminic acid synthase; Region: PseI; TIGR03586
653733002769	NeuB family; Region: NeuB; pfam03102
653733002770	C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615
653733002771	NeuB binding interface [polypeptide binding]; other site
653733002772	putative substrate binding site [chemical binding]; other site
653733002773	pseudaminic acid biosynthesis-associated protein PseG; Region: PseG; TIGR03590
653733002774	Glycosyltransferase family 28 N-terminal domain; Region: Glyco_transf_28; pfam03033
653733002775	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
653733002776	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
653733002777	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
653733002778	glutamate-1-semialdehyde 2,1-aminomutase; Provisional; Region: PRK06209
653733002779	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
653733002780	inhibitor-cofactor binding pocket; inhibition site
653733002781	pyridoxal 5'-phosphate binding site [chemical binding]; other site
653733002782	catalytic residue [active]
653733002783	SpsF is a glycosyltrnasferase implicated in the synthesis of the spore coat; Region: GT2_SpsF; cd02518
653733002784	ligand binding site; other site
653733002785	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
653733002786	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
653733002787	active site
653733002788	catalytic tetrad [active]
653733002789	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
653733002790	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
653733002791	CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513
653733002792	ligand binding site; other site
653733002793	tetramer interface; other site
653733002794	UDP-N-acetylglucosamine 4,6-dehydratase; Region: PseB; TIGR03589
653733002795	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
653733002796	NAD(P) binding site [chemical binding]; other site
653733002797	homodimer interface [polypeptide binding]; other site
653733002798	substrate binding site [chemical binding]; other site
653733002799	active site
653733002800	Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375
653733002801	Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155
653733002802	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
653733002803	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
653733002804	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
653733002805	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
653733002806	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
653733002807	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
653733002808	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
653733002809	NADH-Ubiquinone oxidoreductase (complex I) subunit C-terminus; Region: Oxidored_q1_C; pfam01010
653733002810	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
653733002811	NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638
653733002812	NADH dehydrogenase subunit J; Provisional; Region: PRK06433
653733002813	NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971
653733002814	Protein of unknown function (DUF1688); Region: DUF1688; pfam07958
653733002815	4Fe-4S binding domain; Region: Fer4; pfam00037
653733002816	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
653733002817	NADH dehydrogenase; Region: NADHdh; cl00469
653733002818	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
653733002819	catalytic loop [active]
653733002820	iron binding site [ion binding]; other site
653733002821	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
653733002822	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cd00368
653733002823	molybdopterin cofactor binding site; other site
653733002824	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
653733002825	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
653733002826	SLBB domain; Region: SLBB; pfam10531
653733002827	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589
653733002828	Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257
653733002829	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
653733002830	putative dimer interface [polypeptide binding]; other site
653733002831	[2Fe-2S] cluster binding site [ion binding]; other site
653733002832	NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649
653733002833	NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338
653733002834	NADH dehydrogenase subunit C; Provisional; Region: PRK06074
653733002835	Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; pfam00329
653733002836	NADH dehydrogenase subunit B; Validated; Region: PRK06411
653733002837	NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602
653733002838	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
653733002839	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
653733002840	active site
653733002841	motif I; other site
653733002842	motif II; other site
653733002843	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
653733002844	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
653733002845	HIGH motif; other site
653733002846	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
653733002847	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
653733002848	active site
653733002849	KMSKS motif; other site
653733002850	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
653733002851	tRNA binding surface [nucleotide binding]; other site
653733002852	DNA polymerase III, delta subunit; Region: holA; TIGR01128
653733002853	GTP-binding protein Der; Reviewed; Region: PRK00093
653733002854	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
653733002855	G1 box; other site
653733002856	GTP/Mg2+ binding site [chemical binding]; other site
653733002857	Switch I region; other site
653733002858	G2 box; other site
653733002859	Switch II region; other site
653733002860	G3 box; other site
653733002861	G4 box; other site
653733002862	G5 box; other site
653733002863	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
653733002864	G1 box; other site
653733002865	GTP/Mg2+ binding site [chemical binding]; other site
653733002866	Switch I region; other site
653733002867	G2 box; other site
653733002868	G3 box; other site
653733002869	Switch II region; other site
653733002870	G4 box; other site
653733002871	G5 box; other site
653733002872	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
653733002873	N-acetyl-D-glucosamine binding site [chemical binding]; other site
653733002874	catalytic residue [active]
653733002875	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
653733002876	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
653733002877	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
653733002878	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
653733002879	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
653733002880	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
653733002881	Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518
653733002882	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
653733002883	S-adenosylmethionine binding site [chemical binding]; other site
653733002884	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
653733002885	catalytic core [active]
653733002886	DEDDy 3'-5' exonuclease domain of WRN and similar proteins; Region: WRN_exo; cd06141
653733002887	catalytic site [active]
653733002888	putative active site [active]
653733002889	putative substrate binding site [chemical binding]; other site
653733002890	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
653733002891	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
653733002892	HIGH motif; other site
653733002893	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
653733002894	active site
653733002895	KMSKS motif; other site
653733002896	NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767
653733002897	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
653733002898	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
653733002899	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
653733002900	Walker A/P-loop; other site
653733002901	ATP binding site [chemical binding]; other site
653733002902	Q-loop/lid; other site
653733002903	ABC transporter signature motif; other site
653733002904	Walker B; other site
653733002905	D-loop; other site
653733002906	H-loop/switch region; other site
653733002907	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
653733002908	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
653733002909	FtsX-like permease family; Region: FtsX; pfam02687
653733002910	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
653733002911	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
653733002912	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
653733002913	protein binding site [polypeptide binding]; other site
653733002914	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
653733002915	protein binding site [polypeptide binding]; other site
653733002916	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
653733002917	G1 box; other site
653733002918	GTP/Mg2+ binding site [chemical binding]; other site
653733002919	Switch I region; other site
653733002920	G2 box; other site
653733002921	G3 box; other site
653733002922	Switch II region; other site
653733002923	G4 box; other site
653733002924	G5 box; other site
653733002925	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
653733002926	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
653733002927	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
653733002928	metal-binding site [ion binding]
653733002929	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
653733002930	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
653733002931	metal-binding site [ion binding]
653733002932	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
653733002933	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
653733002934	active site
653733002935	motif I; other site
653733002936	motif II; other site
653733002937	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
653733002938	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
653733002939	P-loop; other site
653733002940	Magnesium ion binding site [ion binding]; other site
653733002941	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
653733002942	Magnesium ion binding site [ion binding]; other site
653733002943	4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337
653733002944	UbiA prenyltransferase family; Region: UbiA; pfam01040
653733002945	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
653733002946	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
653733002947	nucleotide binding pocket [chemical binding]; other site
653733002948	K-X-D-G motif; other site
653733002949	catalytic site [active]
653733002950	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
653733002951	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
653733002952	Helix-hairpin-helix motif; Region: HHH; pfam00633
653733002953	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
653733002954	Dimer interface [polypeptide binding]; other site
653733002955	BRCT sequence motif; other site
653733002956	Predicted membrane protein (DUF2232); Region: DUF2232; cl01728
653733002957	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
653733002958	phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155
653733002959	acyl-activating enzyme (AAE) consensus motif; other site
653733002960	AMP binding site [chemical binding]; other site
653733002961	active site
653733002962	CoA binding site [chemical binding]; other site
653733002963	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
653733002964	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
653733002965	ATP binding site [chemical binding]; other site
653733002966	Mg2+ binding site [ion binding]; other site
653733002967	G-X-G motif; other site
653733002968	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
653733002969	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
653733002970	RNA binding surface [nucleotide binding]; other site
653733002971	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
653733002972	S-adenosylmethionine binding site [chemical binding]; other site
653733002973	CRISPR/Cas system-associated RAMP superfamily protein Cas6f; Region: Cas6_I-F; cd09739
653733002974	CRISPR/Cas system-associated RAMP superfamily protein Csy3; Region: Csy3_I-F; cd09737
653733002975	CRISPR/Cas system-associated RAMP superfamily protein Csy2; Region: Csy2_I-F; cd09736
653733002976	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
653733002977	Transposase; Region: HTH_Tnp_1; pfam01527
653733002978	putative transposase OrfB; Reviewed; Region: PHA02517
653733002979	HTH-like domain; Region: HTH_21; pfam13276
653733002980	Integrase core domain; Region: rve; pfam00665
653733002981	Integrase core domain; Region: rve_3; pfam13683
653733002982	CRISPR/Cas system-associated protein Csy1; Region: Csy1_I-F; cl09829
653733002983	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
653733002984	Transposase; Region: HTH_Tnp_1; pfam01527
653733002985	putative transposase OrfB; Reviewed; Region: PHA02517
653733002986	HTH-like domain; Region: HTH_21; pfam13276
653733002987	Integrase core domain; Region: rve; pfam00665
653733002988	Integrase core domain; Region: rve_3; pfam13683
653733002989	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
653733002990	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
653733002991	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
653733002992	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656
653733002993	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
653733002994	active site
653733002995	catalytic site [active]
653733002996	substrate binding site [chemical binding]; other site
653733002997	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
653733002998	dimerization interface [polypeptide binding]; other site
653733002999	putative Zn2+ binding site [ion binding]; other site
653733003000	putative DNA binding site [nucleotide binding]; other site
653733003001	Flavivirus glycoprotein, central and dimerisation domains; Region: Flavi_glycoprot; pfam00869
653733003002	HTH domain; Region: HTH_11; cl17392
653733003003	Predicted transcriptional regulator [Transcription]; Region: COG2378
653733003004	WYL domain; Region: WYL; pfam13280
653733003005	homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175
653733003006	homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392
653733003007	S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_30; cl17711
653733003008	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
653733003009	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
653733003010	Walker A motif; other site
653733003011	ATP binding site [chemical binding]; other site
653733003012	Walker B motif; other site
653733003013	arginine finger; other site
653733003014	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
653733003015	Response regulator receiver domain; Region: Response_reg; pfam00072
653733003016	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
653733003017	active site
653733003018	phosphorylation site [posttranslational modification]
653733003019	intermolecular recognition site; other site
653733003020	dimerization interface [polypeptide binding]; other site
653733003021	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
653733003022	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
653733003023	metal binding site [ion binding]; metal-binding site
653733003024	active site
653733003025	I-site; other site
653733003026	PilZ domain; Region: PilZ; pfam07238
653733003027	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
653733003028	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
653733003029	putative active site [active]
653733003030	heme pocket [chemical binding]; other site
653733003031	PAS fold; Region: PAS_4; pfam08448
653733003032	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
653733003033	putative active site [active]
653733003034	heme pocket [chemical binding]; other site
653733003035	PAS domain; Region: PAS; smart00091
653733003036	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
653733003037	putative active site [active]
653733003038	heme pocket [chemical binding]; other site
653733003039	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
653733003040	putative active site [active]
653733003041	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
653733003042	heme pocket [chemical binding]; other site
653733003043	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
653733003044	dimer interface [polypeptide binding]; other site
653733003045	phosphorylation site [posttranslational modification]
653733003046	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
653733003047	ATP binding site [chemical binding]; other site
653733003048	Mg2+ binding site [ion binding]; other site
653733003049	G-X-G motif; other site
653733003050	YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486
653733003051	generic binding surface I; other site
653733003052	generic binding surface II; other site
653733003053	Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283
653733003054	putative active site [active]
653733003055	putative catalytic site [active]
653733003056	putative Mg binding site IVb [ion binding]; other site
653733003057	putative phosphate binding site [ion binding]; other site
653733003058	putative DNA binding site [nucleotide binding]; other site
653733003059	putative Mg binding site IVa [ion binding]; other site
653733003060	Protein of unknown function (DUF2023); Region: DUF2023; pfam09633
653733003061	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
653733003062	cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235
653733003063	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
653733003064	catalytic residue [active]
653733003065	Predicted transcriptional regulator [Transcription]; Region: COG1959
653733003066	Transcriptional regulator; Region: Rrf2; pfam02082
653733003067	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
653733003068	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
653733003069	dimer interface [polypeptide binding]; other site
653733003070	pyridoxal 5'-phosphate binding site [chemical binding]; other site
653733003071	catalytic residue [active]
653733003072	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
653733003073	Domain of unknown function DUF20; Region: UPF0118; pfam01594
653733003074	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
653733003075	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
653733003076	NAD(P) binding site [chemical binding]; other site
653733003077	active site
653733003078	Protein of unknown function (DUF2867); Region: DUF2867; pfam11066
653733003079	ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613
653733003080	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
653733003081	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
653733003082	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
653733003083	dimer interface [polypeptide binding]; other site
653733003084	conserved gate region; other site
653733003085	putative PBP binding loops; other site
653733003086	ABC-ATPase subunit interface; other site
653733003087	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
653733003088	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
653733003089	dimer interface [polypeptide binding]; other site
653733003090	conserved gate region; other site
653733003091	putative PBP binding loops; other site
653733003092	ABC-ATPase subunit interface; other site
653733003093	ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118
653733003094	ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296
653733003095	Walker A/P-loop; other site
653733003096	ATP binding site [chemical binding]; other site
653733003097	Q-loop/lid; other site
653733003098	ABC transporter signature motif; other site
653733003099	Walker B; other site
653733003100	D-loop; other site
653733003101	H-loop/switch region; other site
653733003102	TOBE-like domain; Region: TOBE_3; pfam12857
653733003103	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
653733003104	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
653733003105	Active Sites [active]
653733003106	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
653733003107	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
653733003108	Active Sites [active]
653733003109	sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124
653733003110	CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166
653733003111	CysD dimerization site [polypeptide binding]; other site
653733003112	G1 box; other site
653733003113	putative GEF interaction site [polypeptide binding]; other site
653733003114	GTP/Mg2+ binding site [chemical binding]; other site
653733003115	Switch I region; other site
653733003116	G2 box; other site
653733003117	G3 box; other site
653733003118	Switch II region; other site
653733003119	G4 box; other site
653733003120	G5 box; other site
653733003121	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
653733003122	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
653733003123	Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155
653733003124	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
653733003125	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
653733003126	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
653733003127	Transposase; Region: HTH_Tnp_1; pfam01527
653733003128	putative transposase OrfB; Reviewed; Region: PHA02517
653733003129	HTH-like domain; Region: HTH_21; pfam13276
653733003130	Integrase core domain; Region: rve; pfam00665
653733003131	Integrase core domain; Region: rve_3; pfam13683
653733003132	Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201
653733003133	CheB methylesterase; Region: CheB_methylest; pfam01339
653733003134	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
653733003135	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
653733003136	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
653733003137	PAS fold; Region: PAS_3; pfam08447
653733003138	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
653733003139	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
653733003140	dimer interface [polypeptide binding]; other site
653733003141	phosphorylation site [posttranslational modification]
653733003142	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
653733003143	ATP binding site [chemical binding]; other site
653733003144	Mg2+ binding site [ion binding]; other site
653733003145	G-X-G motif; other site
653733003146	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
653733003147	dimerization interface [polypeptide binding]; other site
653733003148	putative DNA binding site [nucleotide binding]; other site
653733003149	putative Zn2+ binding site [ion binding]; other site
653733003150	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174
653733003151	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
653733003152	dimer interface [polypeptide binding]; other site
653733003153	conserved gate region; other site
653733003154	putative PBP binding loops; other site
653733003155	ABC-ATPase subunit interface; other site
653733003156	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
653733003157	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497
653733003158	Response regulator receiver domain; Region: Response_reg; pfam00072
653733003159	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
653733003160	active site
653733003161	phosphorylation site [posttranslational modification]
653733003162	intermolecular recognition site; other site
653733003163	dimerization interface [polypeptide binding]; other site
653733003164	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
653733003165	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
653733003166	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
653733003167	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086
653733003168	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
653733003169	active site
653733003170	Response regulator containing a CheY-like receiver domain and a GGDEF domain [Signal transduction mechanisms]; Region: PleD; COG3706
653733003171	phosphorylation site [posttranslational modification]
653733003172	intermolecular recognition site; other site
653733003173	dimerization interface [polypeptide binding]; other site
653733003174	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
653733003175	active site
653733003176	phosphorylation site [posttranslational modification]
653733003177	intermolecular recognition site; other site
653733003178	dimerization interface [polypeptide binding]; other site
653733003179	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
653733003180	metal binding site [ion binding]; metal-binding site
653733003181	active site
653733003182	I-site; other site
653733003183	Response regulator receiver domain; Region: Response_reg; pfam00072
653733003184	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
653733003185	active site
653733003186	phosphorylation site [posttranslational modification]
653733003187	dimerization interface [polypeptide binding]; other site
653733003188	Bacteriophage CI repressor helix-turn-helix domain; Region: Phage_CI_repr; pfam07022
653733003189	Predicted transcriptional regulator [Transcription]; Region: COG2932
653733003190	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
653733003191	Catalytic site [active]
653733003192	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
653733003193	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
653733003194	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
653733003195	SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500
653733003196	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
653733003197	S-adenosylmethionine binding site [chemical binding]; other site
653733003198	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
653733003199	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153
653733003200	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
653733003201	HI0933-like protein; Region: HI0933_like; pfam03486
653733003202	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
653733003203	GMP synthase; Reviewed; Region: guaA; PRK00074
653733003204	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
653733003205	AMP/PPi binding site [chemical binding]; other site
653733003206	candidate oxyanion hole; other site
653733003207	catalytic triad [active]
653733003208	potential glutamine specificity residues [chemical binding]; other site
653733003209	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
653733003210	ATP Binding subdomain [chemical binding]; other site
653733003211	Ligand Binding sites [chemical binding]; other site
653733003212	Dimerization subdomain; other site
653733003213	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
653733003214	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
653733003215	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
653733003216	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
653733003217	active site
653733003218	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
653733003219	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
653733003220	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
653733003221	Protein of unknown function (DUF2905); Region: DUF2905; pfam11146
653733003222	Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201
653733003223	CheB methylesterase; Region: CheB_methylest; pfam01339
653733003224	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
653733003225	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
653733003226	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
653733003227	PAS fold; Region: PAS_4; pfam08448
653733003228	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
653733003229	putative active site [active]
653733003230	heme pocket [chemical binding]; other site
653733003231	PAS domain S-box; Region: sensory_box; TIGR00229
653733003232	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
653733003233	putative active site [active]
653733003234	heme pocket [chemical binding]; other site
653733003235	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
653733003236	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
653733003237	ATP binding site [chemical binding]; other site
653733003238	Mg2+ binding site [ion binding]; other site
653733003239	G-X-G motif; other site
653733003240	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
653733003241	Response regulator receiver domain; Region: Response_reg; pfam00072
653733003242	active site
653733003243	phosphorylation site [posttranslational modification]
653733003244	intermolecular recognition site; other site
653733003245	dimerization interface [polypeptide binding]; other site
653733003246	Protein of unknown function, DUF486; Region: DUF486; cl01236
653733003247	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339
653733003248	Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097
653733003249	tRNA 2-selenouridine synthase; Provisional; Region: PRK11784
653733003250	Member of the Rhodanese Homology Domain superfamily. This CD includes several putative ATP /GTP binding proteins including E. coli YbbB; Region: RHOD_YbbB; cd01520
653733003251	active site residue [active]
653733003252	selenophosphate synthetase; Provisional; Region: PRK00943
653733003253	Selenophosphate synthetase  (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195
653733003254	dimerization interface [polypeptide binding]; other site
653733003255	putative ATP binding site [chemical binding]; other site
653733003256	Domain of unknown function (DUF4276); Region: DUF4276; pfam14103
653733003257	Predicted ATPase [General function prediction only]; Region: COG4637
653733003258	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
653733003259	Walker A/P-loop; other site
653733003260	ATP binding site [chemical binding]; other site
653733003261	5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082
653733003262	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
653733003263	Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  DHPS, a...; Region: Pterin_binding; cl00219
653733003264	substrate binding pocket [chemical binding]; other site
653733003265	dimer interface [polypeptide binding]; other site
653733003266	inhibitor binding site; inhibition site
653733003267	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
653733003268	B12 binding site [chemical binding]; other site
653733003269	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
653733003270	Flagellar protein FlhE; Region: FlhE; pfam06366
653733003271	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
653733003272	ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263
653733003273	Walker A/P-loop; other site
653733003274	ATP binding site [chemical binding]; other site
653733003275	Q-loop/lid; other site
653733003276	ABC transporter signature motif; other site
653733003277	Walker B; other site
653733003278	D-loop; other site
653733003279	H-loop/switch region; other site
653733003280	ABC-2 type transporter; Region: ABC2_membrane; cl17235
653733003281	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
653733003282	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
653733003283	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
653733003284	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299
653733003285	N-terminal domain interface [polypeptide binding]; other site
653733003286	dimer interface [polypeptide binding]; other site
653733003287	substrate binding pocket (H-site) [chemical binding]; other site
653733003288	Domain of unknown function (DUF3391); Region: DUF3391; pfam11871
653733003289	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
653733003290	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
653733003291	Zn2+ binding site [ion binding]; other site
653733003292	Mg2+ binding site [ion binding]; other site
653733003293	7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696
653733003294	7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695
653733003295	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
653733003296	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
653733003297	ATP binding site [chemical binding]; other site
653733003298	Mg2+ binding site [ion binding]; other site
653733003299	G-X-G motif; other site
653733003300	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
653733003301	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
653733003302	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
653733003303	Response regulator receiver domain; Region: Response_reg; pfam00072
653733003304	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
653733003305	active site
653733003306	phosphorylation site [posttranslational modification]
653733003307	intermolecular recognition site; other site
653733003308	dimerization interface [polypeptide binding]; other site
653733003309	Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862
653733003310	DNA binding site [nucleotide binding]
653733003311	Ectoine synthase; Region: Ectoine_synth; pfam06339
653733003312	diaminobutyrate--2-oxoglutarate aminotransferase; Validated; Region: PRK09264
653733003313	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
653733003314	inhibitor-cofactor binding pocket; inhibition site
653733003315	pyridoxal 5'-phosphate binding site [chemical binding]; other site
653733003316	catalytic residue [active]
653733003317	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
653733003318	Coenzyme A binding pocket [chemical binding]; other site
653733003319	Protein of unknown function (DUF503); Region: DUF503; cl00669
653733003320	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
653733003321	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
653733003322	putative acyl-acceptor binding pocket; other site
653733003323	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
653733003324	Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219
653733003325	3-deoxy-D-manno-octulosonic-acid kinase; Reviewed; Region: PRK01723
653733003326	Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; cl17488
653733003327	Surface antigen; Region: Bac_surface_Ag; pfam01103
653733003328	YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492
653733003329	generic binding surface I; other site
653733003330	Predicted HD-superfamily hydrolase [General function prediction only]; Region: COG3481
653733003331	generic binding surface II; other site
653733003332	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
653733003333	Zn2+ binding site [ion binding]; other site
653733003334	Mg2+ binding site [ion binding]; other site
653733003335	Protein of unknown function DUF47; Region: PhoU_div; pfam01865
653733003336	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
653733003337	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
653733003338	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197
653733003339	active site
653733003340	CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cl11443
653733003341	CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cd09680
653733003342	CRISPR-associated protein Cas10/Csm1, subtype III-A/MTUBE; Region: cas_TM1811_Csm1; TIGR02578
653733003343	CRISPR/Cas system-associated protein Csm2; Region: Csm2_III-A; cl00622
653733003344	CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl17214
653733003345	CRISPR/Cas system-associated RAMP superfamily protein Csm4; Region: Csm4_III-A; cl17438
653733003346	CRISPR/Cas system-associated RAMP superfamily protein Csm5; Region: Csm5_III-A; cl17437
653733003347	Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542
653733003348	Transposase; Region: DDE_Tnp_ISL3; pfam01610
653733003349	CRISPR-associated (Cas) DxTHG family; Region: Cas_DxTHG; pfam09455
653733003350	CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cl17439
653733003351	G10 protein; Region: G10; cl02138
653733003352	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634
653733003353	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725
653733003354	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254
653733003355	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725
653733003356	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
653733003357	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
653733003358	active site
653733003359	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
653733003360	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139
653733003361	conserved cys residue [active]
653733003362	Protein required for attachment to host cells; Region: Host_attach; pfam10116
653733003363	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
653733003364	S-adenosylmethionine binding site [chemical binding]; other site
653733003365	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
653733003366	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
653733003367	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
653733003368	catalytic residue [active]
653733003369	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
653733003370	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
653733003371	substrate binding pocket [chemical binding]; other site
653733003372	membrane-bound complex binding site; other site
653733003373	hinge residues; other site
653733003374	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
653733003375	PAS fold; Region: PAS_3; pfam08447
653733003376	putative active site [active]
653733003377	heme pocket [chemical binding]; other site
653733003378	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
653733003379	dimer interface [polypeptide binding]; other site
653733003380	phosphorylation site [posttranslational modification]
653733003381	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
653733003382	ATP binding site [chemical binding]; other site
653733003383	Mg2+ binding site [ion binding]; other site
653733003384	G-X-G motif; other site
653733003385	Response regulator receiver domain; Region: Response_reg; pfam00072
653733003386	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
653733003387	active site
653733003388	phosphorylation site [posttranslational modification]
653733003389	intermolecular recognition site; other site
653733003390	dimerization interface [polypeptide binding]; other site
653733003391	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086
653733003392	phosphotransacetylase; Reviewed; Region: eutD; PRK09653
653733003393	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
653733003394	propionate/acetate kinase; Provisional; Region: PRK12379
653733003395	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
653733003396	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
653733003397	FtsX-like permease family; Region: FtsX; pfam02687
653733003398	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
653733003399	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
653733003400	Walker A/P-loop; other site
653733003401	ATP binding site [chemical binding]; other site
653733003402	Q-loop/lid; other site
653733003403	ABC transporter signature motif; other site
653733003404	Walker B; other site
653733003405	D-loop; other site
653733003406	H-loop/switch region; other site
653733003407	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
653733003408	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
653733003409	active site
653733003410	HIGH motif; other site
653733003411	nucleotide binding site [chemical binding]; other site
653733003412	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
653733003413	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
653733003414	active site
653733003415	KMSKS motif; other site
653733003416	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
653733003417	tRNA binding surface [nucleotide binding]; other site
653733003418	anticodon binding site; other site
653733003419	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
653733003420	Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157
653733003421	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
653733003422	dimerization interface [polypeptide binding]; other site
653733003423	active site
653733003424	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cl01482
653733003425	dimer interface [polypeptide binding]; other site
653733003426	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
653733003427	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
653733003428	active site
653733003429	phosphorylation site [posttranslational modification]
653733003430	intermolecular recognition site; other site
653733003431	dimerization interface [polypeptide binding]; other site
653733003432	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
653733003433	DNA binding site [nucleotide binding]
653733003434	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
653733003435	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
653733003436	dimerization interface [polypeptide binding]; other site
653733003437	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
653733003438	dimer interface [polypeptide binding]; other site
653733003439	phosphorylation site [posttranslational modification]
653733003440	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
653733003441	ATP binding site [chemical binding]; other site
653733003442	Mg2+ binding site [ion binding]; other site
653733003443	G-X-G motif; other site
653733003444	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
653733003445	MarR family; Region: MarR_2; cl17246
653733003446	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
653733003447	Zn2+ binding site [ion binding]; other site
653733003448	Mg2+ binding site [ion binding]; other site
653733003449	Protein of unknown function, DUF485; Region: DUF485; pfam04341
653733003450	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
653733003451	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480
653733003452	Na binding site [ion binding]; other site
653733003453	Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905
653733003454	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
653733003455	ligand binding site [chemical binding]; other site
653733003456	flexible hinge region; other site
653733003457	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
653733003458	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
653733003459	metal binding triad; other site
653733003460	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
653733003461	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
653733003462	active site
653733003463	catalytic site [active]
653733003464	substrate binding site [chemical binding]; other site
653733003465	pyruvate carboxylase; Reviewed; Region: PRK12999
653733003466	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
653733003467	ATP-grasp domain; Region: ATP-grasp_4; cl17255
653733003468	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
653733003469	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
653733003470	active site
653733003471	catalytic residues [active]
653733003472	metal binding site [ion binding]; metal-binding site
653733003473	homodimer binding site [polypeptide binding]; other site
653733003474	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
653733003475	carboxyltransferase (CT) interaction site; other site
653733003476	biotinylation site [posttranslational modification]; other site
653733003477	PAS domain S-box; Region: sensory_box; TIGR00229
653733003478	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
653733003479	dimer interface [polypeptide binding]; other site
653733003480	phosphorylation site [posttranslational modification]
653733003481	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
653733003482	ATP binding site [chemical binding]; other site
653733003483	Mg2+ binding site [ion binding]; other site
653733003484	G-X-G motif; other site
653733003485	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
653733003486	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
653733003487	dimerization interface [polypeptide binding]; other site
653733003488	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
653733003489	dimer interface [polypeptide binding]; other site
653733003490	putative CheW interface [polypeptide binding]; other site
653733003491	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190
653733003492	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
653733003493	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
653733003494	homodimer interface [polypeptide binding]; other site
653733003495	NADP binding site [chemical binding]; other site
653733003496	substrate binding site [chemical binding]; other site
653733003497	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
653733003498	F plasmid transfer operon, TraF, protein; Region: TraF_2; pfam13729
653733003499	CHAD domain; Region: CHAD; pfam05235
653733003500	Lipid A disaccharide synthetase [Cell envelope biogenesis, outer membrane]; Region: LpxB; COG0763
653733003501	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
653733003502	SnoaL-like domain; Region: SnoaL_3; pfam13474
653733003503	Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504
653733003504	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
653733003505	nucleoside/Zn binding site; other site
653733003506	dimer interface [polypeptide binding]; other site
653733003507	catalytic motif [active]
653733003508	Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740
653733003509	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058
653733003510	Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374
653733003511	Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374
653733003512	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
653733003513	Hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). These enzymes belong to the peptidase family M52. Maturation of [FeNi] hydrogenases includes formation of the nickel metallocenter, proteolytic processing...; Region: H2MP; cl00477
653733003514	nickel binding site [ion binding]; other site
653733003515	Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068
653733003516	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
653733003517	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
653733003518	intersubunit interface [polypeptide binding]; other site
653733003519	Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437
653733003520	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
653733003521	active site
653733003522	phosphorylation site [posttranslational modification]
653733003523	intermolecular recognition site; other site
653733003524	dimerization interface [polypeptide binding]; other site
653733003525	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
653733003526	Zn2+ binding site [ion binding]; other site
653733003527	Mg2+ binding site [ion binding]; other site
653733003528	Uncharacterized conserved protein [Function unknown]; Region: COG0432
653733003529	Rubrerythrin [Energy production and conversion]; Region: COG1592
653733003530	Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041
653733003531	binuclear metal center [ion binding]; other site
653733003532	Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729
653733003533	iron binding site [ion binding]; other site
653733003534	Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322
653733003535	Na binding site [ion binding]; other site
653733003536	Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286
653733003537	catalytic motif [active]
653733003538	Zn binding site [ion binding]; other site
653733003539	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
653733003540	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
653733003541	dimer interface [polypeptide binding]; other site
653733003542	active site
653733003543	glycine-pyridoxal phosphate binding site [chemical binding]; other site
653733003544	folate binding site [chemical binding]; other site
653733003545	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
653733003546	Lumazine binding domain; Region: Lum_binding; pfam00677
653733003547	Lumazine binding domain; Region: Lum_binding; pfam00677
653733003548	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
653733003549	trimer interface [polypeptide binding]; other site
653733003550	active site
653733003551	Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469
653733003552	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
653733003553	domain interfaces; other site
653733003554	active site
653733003555	Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168
653733003556	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
653733003557	substrate binding site [chemical binding]; other site
653733003558	ATP binding site [chemical binding]; other site
653733003559	Uncharacterized conserved protein [Function unknown]; Region: COG2127
653733003560	ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639
653733003561	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
653733003562	Walker A motif; other site
653733003563	ATP binding site [chemical binding]; other site
653733003564	Walker B motif; other site
653733003565	arginine finger; other site
653733003566	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
653733003567	Walker A motif; other site
653733003568	ATP binding site [chemical binding]; other site
653733003569	Walker B motif; other site
653733003570	arginine finger; other site
653733003571	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
653733003572	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
653733003573	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
653733003574	putative active site [active]
653733003575	heme pocket [chemical binding]; other site
653733003576	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
653733003577	putative active site [active]
653733003578	heme pocket [chemical binding]; other site
653733003579	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
653733003580	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
653733003581	ATP binding site [chemical binding]; other site
653733003582	Mg2+ binding site [ion binding]; other site
653733003583	G-X-G motif; other site
653733003584	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
653733003585	Protein export membrane protein; Region: SecD_SecF; cl14618
653733003586	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
653733003587	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
653733003588	HlyD family secretion protein; Region: HlyD_3; pfam13437
653733003589	Carboxysome Shell Carbonic Anhydrase; Region: CsoSCA; cl07510
653733003590	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
653733003591	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
653733003592	putative active site [active]
653733003593	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
653733003594	EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318
653733003595	putative dimer interface [polypeptide binding]; other site
653733003596	putative anticodon binding site; other site
653733003597	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
653733003598	homodimer interface [polypeptide binding]; other site
653733003599	motif 1; other site
653733003600	motif 2; other site
653733003601	active site
653733003602	motif 3; other site
653733003603	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
653733003604	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
653733003605	GIY-YIG motif/motif A; other site
653733003606	active site
653733003607	catalytic site [active]
653733003608	putative DNA binding site [nucleotide binding]; other site
653733003609	metal binding site [ion binding]; metal-binding site
653733003610	UvrB/uvrC motif; Region: UVR; pfam02151
653733003611	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
653733003612	H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815
653733003613	DNA binding site [nucleotide binding]
653733003614	Cation transport protein; Region: TrkH; cl17365
653733003615	potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496
653733003616	TrkA-N domain; Region: TrkA_N; pfam02254
653733003617	TrkA-C domain; Region: TrkA_C; pfam02080
653733003618	TrkA-N domain; Region: TrkA_N; pfam02254
653733003619	TrkA-C domain; Region: TrkA_C; pfam02080
653733003620	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
653733003621	binding surface
653733003622	TPR motif; other site
653733003623	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
653733003624	binding surface
653733003625	TPR motif; other site
653733003626	TPR repeat; Region: TPR_11; pfam13414
653733003627	dihydroorotase; Validated; Region: pyrC; PRK09357
653733003628	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
653733003629	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
653733003630	active site
653733003631	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
653733003632	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
653733003633	active site
653733003634	HIGH motif; other site
653733003635	dimer interface [polypeptide binding]; other site
653733003636	KMSKS motif; other site
653733003637	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
653733003638	RNA binding surface [nucleotide binding]; other site
653733003639	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
653733003640	FeS/SAM binding site; other site
653733003641	Radical SAM superfamily; Region: Radical_SAM; pfam04055
653733003642	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
653733003643	FAD binding domain; Region: FAD_binding_4; pfam01565
653733003644	sn-glycerol-3-phosphate dehydrogenase subunit C; Provisional; Region: glpC; PRK11168
653733003645	Cysteine-rich domain; Region: CCG; pfam02754
653733003646	Cysteine-rich domain; Region: CCG; pfam02754
653733003647	Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822
653733003648	active site
653733003649	catalytic triad [active]
653733003650	oxyanion hole [active]
653733003651	switch loop; other site
653733003652	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181
653733003653	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
653733003654	Walker A/P-loop; other site
653733003655	ATP binding site [chemical binding]; other site
653733003656	Q-loop/lid; other site
653733003657	ABC transporter signature motif; other site
653733003658	Walker B; other site
653733003659	D-loop; other site
653733003660	H-loop/switch region; other site
653733003661	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127
653733003662	FtsX-like permease family; Region: FtsX; pfam02687
653733003663	ribonuclease R; Region: RNase_R; TIGR02063
653733003664	RNB domain; Region: RNB; pfam00773
653733003665	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
653733003666	RNA binding site [nucleotide binding]; other site
653733003667	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
653733003668	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
653733003669	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290
653733003670	DctM-like transporters; Region: DctM; pfam06808
653733003671	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
653733003672	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
653733003673	CoenzymeA binding site [chemical binding]; other site
653733003674	subunit interaction site [polypeptide binding]; other site
653733003675	PHB binding site; other site
653733003676	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239
653733003677	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
653733003678	dimer interface [polypeptide binding]; other site
653733003679	conserved gate region; other site
653733003680	ABC-ATPase subunit interface; other site
653733003681	ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172
653733003682	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
653733003683	Walker A/P-loop; other site
653733003684	ATP binding site [chemical binding]; other site
653733003685	Q-loop/lid; other site
653733003686	ABC transporter signature motif; other site
653733003687	Walker B; other site
653733003688	D-loop; other site
653733003689	H-loop/switch region; other site
653733003690	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
653733003691	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
653733003692	Walker A/P-loop; other site
653733003693	ATP binding site [chemical binding]; other site
653733003694	Q-loop/lid; other site
653733003695	ABC transporter signature motif; other site
653733003696	Walker B; other site
653733003697	D-loop; other site
653733003698	H-loop/switch region; other site
653733003699	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
653733003700	Nitrogen regulatory protein P-II; Region: P-II; cl00412
653733003701	Nitrogen regulatory protein P-II; Region: P-II; smart00938
653733003702	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
653733003703	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
653733003704	TrkA-C domain; Region: TrkA_C; pfam02080
653733003705	Protein of unknown function (DUF2892); Region: DUF2892; pfam11127
653733003706	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
653733003707	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
653733003708	Walker A motif; other site
653733003709	ATP binding site [chemical binding]; other site
653733003710	Walker B motif; other site
653733003711	arginine finger; other site
653733003712	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
653733003713	Holliday junction DNA helicase, RuvA subunit; Region: ruvA; TIGR00084
653733003714	RuvA N terminal domain; Region: RuvA_N; pfam01330
653733003715	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
653733003716	active site
653733003717	putative DNA-binding cleft [nucleotide binding]; other site
653733003718	dimer interface [polypeptide binding]; other site
653733003719	hypothetical protein; Validated; Region: PRK00110
653733003720	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
653733003721	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
653733003722	active site
653733003723	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
653733003724	heterotetramer interface [polypeptide binding]; other site
653733003725	active site pocket [active]
653733003726	cleavage site
653733003727	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
653733003728	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
653733003729	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
653733003730	PAS domain; Region: PAS_9; pfam13426
653733003731	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
653733003732	putative active site [active]
653733003733	heme pocket [chemical binding]; other site
653733003734	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
653733003735	GAF domain; Region: GAF; pfam01590
653733003736	PAS domain S-box; Region: sensory_box; TIGR00229
653733003737	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
653733003738	putative active site [active]
653733003739	heme pocket [chemical binding]; other site
653733003740	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
653733003741	putative active site [active]
653733003742	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
653733003743	heme pocket [chemical binding]; other site
653733003744	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
653733003745	dimer interface [polypeptide binding]; other site
653733003746	phosphorylation site [posttranslational modification]
653733003747	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
653733003748	ATP binding site [chemical binding]; other site
653733003749	G-X-G motif; other site
653733003750	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
653733003751	PAS fold; Region: PAS_3; pfam08447
653733003752	putative active site [active]
653733003753	heme pocket [chemical binding]; other site
653733003754	PAS fold; Region: PAS_3; pfam08447
653733003755	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
653733003756	PAS domain; Region: PAS_9; pfam13426
653733003757	putative active site [active]
653733003758	heme pocket [chemical binding]; other site
653733003759	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
653733003760	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
653733003761	ATP binding site [chemical binding]; other site
653733003762	Mg2+ binding site [ion binding]; other site
653733003763	G-X-G motif; other site
653733003764	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
653733003765	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086
653733003766	nitrogen fixation negative regulator NifL; Region: nifL_nitrog; TIGR02938
653733003767	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
653733003768	putative active site [active]
653733003769	heme pocket [chemical binding]; other site
653733003770	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
653733003771	dimer interface [polypeptide binding]; other site
653733003772	phosphorylation site [posttranslational modification]
653733003773	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
653733003774	ATP binding site [chemical binding]; other site
653733003775	Mg2+ binding site [ion binding]; other site
653733003776	G-X-G motif; other site
653733003777	Bacitracin resistance protein BacA; Region: BacA; pfam02673
653733003778	AAA domain; Region: AAA_17; pfam13207
653733003779	AAA domain; Region: AAA_33; pfam13671
653733003780	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187
653733003781	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
653733003782	S-adenosylmethionine binding site [chemical binding]; other site
653733003783	oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290
653733003784	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_5; cd09610
653733003785	active site
653733003786	Zn binding site [ion binding]; other site
653733003787	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
653733003788	homopentamer interface [polypeptide binding]; other site
653733003789	active site
653733003790	RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223
653733003791	putative RNA binding site [nucleotide binding]; other site
653733003792	arginine decarboxylase; Provisional; Region: PRK05354
653733003793	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830
653733003794	dimer interface [polypeptide binding]; other site
653733003795	active site
653733003796	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
653733003797	catalytic residues [active]
653733003798	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
653733003799	Domain of unknown function (DUF1924); Region: DUF1924; pfam09086
653733003800	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
653733003801	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
653733003802	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
653733003803	Thermotoga maritima CorA-like family; Region: TmCorA-like; cd12822
653733003804	oligomer interface [polypeptide binding]; other site
653733003805	metal binding site [ion binding]; metal-binding site
653733003806	metal binding site [ion binding]; metal-binding site
653733003807	putative Cl binding site [ion binding]; other site
653733003808	aspartate ring; other site
653733003809	basic sphincter; other site
653733003810	hydrophobic gate; other site
653733003811	periplasmic entrance; other site
653733003812	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
653733003813	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
653733003814	Walker A/P-loop; other site
653733003815	ATP binding site [chemical binding]; other site
653733003816	Q-loop/lid; other site
653733003817	ABC transporter signature motif; other site
653733003818	Walker B; other site
653733003819	D-loop; other site
653733003820	H-loop/switch region; other site
653733003821	Methionyl-tRNA formyltransferase [Translation, ribosomal structure and biogenesis]; Region: Fmt; COG0223
653733003822	Formyltransferase, catalytic core domain; Region: FMT_core; cd08369
653733003823	active site
653733003824	substrate binding site [chemical binding]; other site
653733003825	cosubstrate binding site; other site
653733003826	catalytic site [active]
653733003827	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
653733003828	substrate binding site [chemical binding]; other site
653733003829	gamma-glutamyl kinase; Provisional; Region: PRK05429
653733003830	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
653733003831	nucleotide binding site [chemical binding]; other site
653733003832	homotetrameric interface [polypeptide binding]; other site
653733003833	putative phosphate binding site [ion binding]; other site
653733003834	putative allosteric binding site; other site
653733003835	PUA domain; Region: PUA; pfam01472
653733003836	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
653733003837	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
653733003838	putative catalytic cysteine [active]
653733003839	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
653733003840	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
653733003841	active site
653733003842	(T/H)XGH motif; other site
653733003843	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
653733003844	metal binding site 2 [ion binding]; metal-binding site
653733003845	putative DNA binding helix; other site
653733003846	metal binding site 1 [ion binding]; metal-binding site
653733003847	dimer interface [polypeptide binding]; other site
653733003848	structural Zn2+ binding site [ion binding]; other site
653733003849	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
653733003850	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
653733003851	peptide chain release factor 2; Validated; Region: prfB; PRK00578
653733003852	This domain is found in peptide chain release factors; Region: PCRF; smart00937
653733003853	RF-1 domain; Region: RF-1; pfam00472
653733003854	TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358
653733003855	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
653733003856	substrate binding pocket [chemical binding]; other site
653733003857	membrane-bound complex binding site; other site
653733003858	hinge residues; other site
653733003859	Domain of unknown function (DUF1850); Region: DUF1850; cl01950
653733003860	TRAP transporter, 4TM/12TM fusion protein; Region: TRAP_fused; TIGR02123
653733003861	DctM-like transporters; Region: DctM; pfam06808
653733003862	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
653733003863	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
653733003864	substrate binding pocket [chemical binding]; other site
653733003865	membrane-bound complex binding site; other site
653733003866	hinge residues; other site
653733003867	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
653733003868	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
653733003869	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
653733003870	dimer interface [polypeptide binding]; other site
653733003871	phosphorylation site [posttranslational modification]
653733003872	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
653733003873	ATP binding site [chemical binding]; other site
653733003874	Mg2+ binding site [ion binding]; other site
653733003875	G-X-G motif; other site
653733003876	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
653733003877	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
653733003878	active site
653733003879	phosphorylation site [posttranslational modification]
653733003880	intermolecular recognition site; other site
653733003881	dimerization interface [polypeptide binding]; other site
653733003882	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
653733003883	Walker A motif; other site
653733003884	ATP binding site [chemical binding]; other site
653733003885	Walker B motif; other site
653733003886	arginine finger; other site
653733003887	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
653733003888	ABC transporter ATPase component; Reviewed; Region: PRK11147
653733003889	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
653733003890	Walker A/P-loop; other site
653733003891	ATP binding site [chemical binding]; other site
653733003892	Q-loop/lid; other site
653733003893	ABC transporter signature motif; other site
653733003894	Walker B; other site
653733003895	D-loop; other site
653733003896	H-loop/switch region; other site
653733003897	ABC transporter; Region: ABC_tran_2; pfam12848
653733003898	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
653733003899	N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573
653733003900	N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381
653733003901	putative active site; other site
653733003902	catalytic triad [active]
653733003903	putative dimer interface [polypeptide binding]; other site
653733003904	Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113
653733003905	Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371
653733003906	TRAP-type uncharacterized transport system, fused permease components [General function prediction only]; Region: COG4666
653733003907	TRAP-type uncharacterized transport system, fused permease components [General function prediction only]; Region: COG4666
653733003908	Domain of unknown function (DUF3394); Region: DUF3394; pfam11874
653733003909	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
653733003910	TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358
653733003911	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
653733003912	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
653733003913	active site
653733003914	phosphorylation site [posttranslational modification]
653733003915	intermolecular recognition site; other site
653733003916	dimerization interface [polypeptide binding]; other site
653733003917	flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622
653733003918	flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303
653733003919	flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK12696
653733003920	Flagellar L-ring protein; Region: FlgH; pfam02107
653733003921	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
653733003922	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
653733003923	substrate binding site [chemical binding]; other site
653733003924	hexamer interface [polypeptide binding]; other site
653733003925	metal binding site [ion binding]; metal-binding site
653733003926	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
653733003927	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
653733003928	catalytic residue [active]
653733003929	putative FPP diphosphate  binding site; other site
653733003930	putative FPP binding hydrophobic cleft; other site
653733003931	dimer interface [polypeptide binding]; other site
653733003932	putative IPP diphosphate binding site; other site
653733003933	MltA specific insert domain; Region: MltA; smart00925
653733003934	3D domain; Region: 3D; pfam06725
653733003935	putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12648
653733003936	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
653733003937	Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111
653733003938	Domain of unknown function (DUF4040); Region: DUF4040; cl00676
653733003939	putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12573
653733003940	putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK09094
653733003941	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12666
653733003942	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
653733003943	putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965
653733003944	putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK06161
653733003945	putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674
653733003946	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
653733003947	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
653733003948	ATP binding site [chemical binding]; other site
653733003949	Mg++ binding site [ion binding]; other site
653733003950	motif III; other site
653733003951	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
653733003952	nucleotide binding region [chemical binding]; other site
653733003953	ATP-binding site [chemical binding]; other site
653733003954	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
653733003955	active site
653733003956	CHASE domain; Region: CHASE; pfam03924
653733003957	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
653733003958	PAS domain; Region: PAS_9; pfam13426
653733003959	putative active site [active]
653733003960	heme pocket [chemical binding]; other site
653733003961	PAS fold; Region: PAS_4; pfam08448
653733003962	PAS domain S-box; Region: sensory_box; TIGR00229
653733003963	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
653733003964	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
653733003965	dimer interface [polypeptide binding]; other site
653733003966	phosphorylation site [posttranslational modification]
653733003967	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
653733003968	ATP binding site [chemical binding]; other site
653733003969	Mg2+ binding site [ion binding]; other site
653733003970	G-X-G motif; other site
653733003971	Pyruvate-formate lyase-activating enzyme [Posttranslational modification, protein turnover, chaperones]; Region: PflA; COG1180
653733003972	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
653733003973	FeS/SAM binding site; other site
653733003974	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
653733003975	tandem repeat interface [polypeptide binding]; other site
653733003976	oligomer interface [polypeptide binding]; other site
653733003977	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
653733003978	active site residues [active]
653733003979	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
653733003980	Uncharacterized ALDH (y4uC) with similarity to Tortula ruralis aldehyde dehydrogenase ALDH21A1; Region: ALDH_y4uC; cd07149
653733003981	NAD(P) binding site [chemical binding]; other site
653733003982	catalytic residues [active]
653733003983	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
653733003984	MPT binding site; other site
653733003985	trimer interface [polypeptide binding]; other site
653733003986	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
653733003987	Ligand Binding Site [chemical binding]; other site
653733003988	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158
653733003989	Peptidase family M50; Region: Peptidase_M50; pfam02163
653733003990	active site
653733003991	putative substrate binding region [chemical binding]; other site
653733003992	Predicted membrane protein [Function unknown]; Region: COG2119
653733003993	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
653733003994	Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979
653733003995	Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187
653733003996	dimer interface [polypeptide binding]; other site
653733003997	active site
653733003998	metal binding site [ion binding]; metal-binding site
653733003999	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
653733004000	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
653733004001	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
653733004002	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066
653733004003	active site
653733004004	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
653733004005	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
653733004006	DNA binding site [nucleotide binding]
653733004007	catalytic residue [active]
653733004008	H2TH interface [polypeptide binding]; other site
653733004009	putative catalytic residues [active]
653733004010	turnover-facilitating residue; other site
653733004011	intercalation triad [nucleotide binding]; other site
653733004012	8OG recognition residue [nucleotide binding]; other site
653733004013	putative reading head residues; other site
653733004014	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
653733004015	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
653733004016	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
653733004017	Major Facilitator Superfamily; Region: MFS_1; pfam07690
653733004018	putative substrate translocation pore; other site
653733004019	polyphosphate:AMP phosphotransferase; Region: poly_P_AMP_trns; TIGR03708
653733004020	Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971
653733004021	Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971
653733004022	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
653733004023	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
653733004024	nucleoside/Zn binding site; other site
653733004025	dimer interface [polypeptide binding]; other site
653733004026	catalytic motif [active]
653733004027	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
653733004028	ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125
653733004029	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
653733004030	FeS/SAM binding site; other site
653733004031	TRAM domain; Region: TRAM; cl01282
653733004032	Protein of unknown function (DUF502); Region: DUF502; pfam04367
653733004033	Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071
653733004034	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
653733004035	catalytic triad [active]
653733004036	Putative amidoligase enzyme; Region: Amidoligase_2; pfam12224
653733004037	multifunctional aminopeptidase A; Provisional; Region: PRK00913
653733004038	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
653733004039	interface (dimer of trimers) [polypeptide binding]; other site
653733004040	Substrate-binding/catalytic site; other site
653733004041	Zn-binding sites [ion binding]; other site
653733004042	mRNA capping enzyme, paramyxovirus family; Region: paramyx_RNAcap; TIGR04198
653733004043	Family description; Region: DsbD_2; pfam13386
653733004044	heat shock protein HtpX; Provisional; Region: PRK05457
653733004045	cobalt transport protein CbiM; Validated; Region: PRK06265
653733004046	Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891
653733004047	cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454
653733004048	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
653733004049	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
653733004050	Walker A/P-loop; other site
653733004051	ATP binding site [chemical binding]; other site
653733004052	Q-loop/lid; other site
653733004053	ABC transporter signature motif; other site
653733004054	Walker B; other site
653733004055	D-loop; other site
653733004056	H-loop/switch region; other site
653733004057	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
653733004058	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
653733004059	putative active site [active]
653733004060	heme pocket [chemical binding]; other site
653733004061	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
653733004062	PAS fold; Region: PAS_3; pfam08447
653733004063	putative active site [active]
653733004064	heme pocket [chemical binding]; other site
653733004065	PAS domain; Region: PAS_8; pfam13188
653733004066	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
653733004067	putative active site [active]
653733004068	heme pocket [chemical binding]; other site
653733004069	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
653733004070	ATP binding site [chemical binding]; other site
653733004071	Mg2+ binding site [ion binding]; other site
653733004072	G-X-G motif; other site
653733004073	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
653733004074	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
653733004075	substrate binding pocket [chemical binding]; other site
653733004076	membrane-bound complex binding site; other site
653733004077	hinge residues; other site
653733004078	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
653733004079	PAS fold; Region: PAS_3; pfam08447
653733004080	putative active site [active]
653733004081	heme pocket [chemical binding]; other site
653733004082	PAS domain; Region: PAS; smart00091
653733004083	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
653733004084	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
653733004085	dimer interface [polypeptide binding]; other site
653733004086	phosphorylation site [posttranslational modification]
653733004087	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
653733004088	ATP binding site [chemical binding]; other site
653733004089	Mg2+ binding site [ion binding]; other site
653733004090	G-X-G motif; other site
653733004091	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
653733004092	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
653733004093	active site
653733004094	phosphorylation site [posttranslational modification]
653733004095	intermolecular recognition site; other site
653733004096	dimerization interface [polypeptide binding]; other site
653733004097	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
653733004098	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
653733004099	active site
653733004100	phosphorylation site [posttranslational modification]
653733004101	intermolecular recognition site; other site
653733004102	dimerization interface [polypeptide binding]; other site
653733004103	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
653733004104	Walker A motif; other site
653733004105	ATP binding site [chemical binding]; other site
653733004106	Walker B motif; other site
653733004107	arginine finger; other site
653733004108	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
653733004109	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
653733004110	dimerization interface [polypeptide binding]; other site
653733004111	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
653733004112	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
653733004113	dimer interface [polypeptide binding]; other site
653733004114	putative CheW interface [polypeptide binding]; other site
653733004115	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
653733004116	Zn2+ binding site [ion binding]; other site
653733004117	Mg2+ binding site [ion binding]; other site
653733004118	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
653733004119	Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049
653733004120	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
653733004121	HAMP domain; Region: HAMP; pfam00672
653733004122	dimerization interface [polypeptide binding]; other site
653733004123	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
653733004124	dimer interface [polypeptide binding]; other site
653733004125	putative CheW interface [polypeptide binding]; other site
653733004126	TPR repeat; Region: TPR_11; pfam13414
653733004127	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
653733004128	binding surface
653733004129	TPR motif; other site
653733004130	TPR repeat; Region: TPR_11; pfam13414
653733004131	FlaG protein; Region: FlaG; pfam03646
653733004132	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
653733004133	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
653733004134	Response regulator receiver domain; Region: Response_reg; pfam00072
653733004135	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
653733004136	active site
653733004137	phosphorylation site [posttranslational modification]
653733004138	intermolecular recognition site; other site
653733004139	dimerization interface [polypeptide binding]; other site
653733004140	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
653733004141	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
653733004142	active site
653733004143	phosphorylation site [posttranslational modification]
653733004144	intermolecular recognition site; other site
653733004145	dimerization interface [polypeptide binding]; other site
653733004146	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
653733004147	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
653733004148	dimer interface [polypeptide binding]; other site
653733004149	putative CheW interface [polypeptide binding]; other site
653733004150	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
653733004151	putative binding surface; other site
653733004152	active site
653733004153	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
653733004154	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
653733004155	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
653733004156	ATP binding site [chemical binding]; other site
653733004157	Mg2+ binding site [ion binding]; other site
653733004158	G-X-G motif; other site
653733004159	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
653733004160	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
653733004161	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
653733004162	ATP binding site [chemical binding]; other site
653733004163	Mg2+ binding site [ion binding]; other site
653733004164	G-X-G motif; other site
653733004165	CheD chemotactic sensory transduction; Region: CheD; cl00810
653733004166	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
653733004167	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
653733004168	active site
653733004169	phosphorylation site [posttranslational modification]
653733004170	intermolecular recognition site; other site
653733004171	dimerization interface [polypeptide binding]; other site
653733004172	CheB methylesterase; Region: CheB_methylest; pfam01339
653733004173	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
653733004174	Clp amino terminal domain; Region: Clp_N; pfam02861
653733004175	Clp amino terminal domain; Region: Clp_N; pfam02861
653733004176	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
653733004177	Walker A motif; other site
653733004178	ATP binding site [chemical binding]; other site
653733004179	Walker B motif; other site
653733004180	arginine finger; other site
653733004181	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
653733004182	Walker A motif; other site
653733004183	ATP binding site [chemical binding]; other site
653733004184	Walker B motif; other site
653733004185	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
653733004186	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307
653733004187	A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168
653733004188	Uncharacterized conserved protein [Function unknown]; Region: COG2308
653733004189	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
653733004190	trimer interface [polypeptide binding]; other site
653733004191	active site
653733004192	Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805
653733004193	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
653733004194	twin arginine translocase protein A; Provisional; Region: tatA; PRK00575
653733004195	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
653733004196	Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434
653733004197	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
653733004198	Acetyl-CoA acetyltransferase [Lipid metabolism]; Region: PaaJ; COG0183
653733004199	Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2  has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829
653733004200	active site
653733004201	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
653733004202	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
653733004203	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
653733004204	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
653733004205	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
653733004206	Soluble P-type ATPase [General function prediction only]; Region: COG4087
653733004207	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
653733004208	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
653733004209	soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249
653733004210	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
653733004211	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
653733004212	ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837
653733004213	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
653733004214	ATP binding site [chemical binding]; other site
653733004215	Mg++ binding site [ion binding]; other site
653733004216	motif III; other site
653733004217	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
653733004218	nucleotide binding region [chemical binding]; other site
653733004219	ATP-binding site [chemical binding]; other site
653733004220	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
653733004221	homotrimer interaction site [polypeptide binding]; other site
653733004222	zinc binding site [ion binding]; other site
653733004223	CDP-binding sites; other site
653733004224	NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255
653733004225	ATP-NAD kinase; Region: NAD_kinase; pfam01513
653733004226	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
653733004227	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
653733004228	Walker A/P-loop; other site
653733004229	ATP binding site [chemical binding]; other site
653733004230	Q-loop/lid; other site
653733004231	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
653733004232	ABC transporter signature motif; other site
653733004233	Walker B; other site
653733004234	D-loop; other site
653733004235	H-loop/switch region; other site
653733004236	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
653733004237	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
653733004238	dimerization interface 3.5A [polypeptide binding]; other site
653733004239	active site
653733004240	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
653733004241	Protein export membrane protein; Region: SecD_SecF; cl14618
653733004242	Protein export membrane protein; Region: SecD_SecF; cl14618
653733004243	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
653733004244	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
653733004245	HlyD family secretion protein; Region: HlyD_3; pfam13437
653733004246	Predicted membrane protein [Function unknown]; Region: COG3671
653733004247	GlpM protein; Region: GlpM; pfam06942
653733004248	NAD-dependent protein deacetylases, SIR2 family [Transcription]; Region: SIR2; COG0846
653733004249	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
653733004250	Phosphoenolpyruvate:glucose-phosphotransferase regulator; Region: MtfA; pfam06167
653733004251	Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cl00019
653733004252	ADP-ribose binding site [chemical binding]; other site
653733004253	Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479
653733004254	Peptidase family M48; Region: Peptidase_M48; cl12018
653733004255	Bacterial SH3 domain; Region: SH3_4; pfam06347
653733004256	CHASE2 domain; Region: CHASE2; pfam05226
653733004257	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
653733004258	cyclase homology domain; Region: CHD; cd07302
653733004259	nucleotidyl binding site; other site
653733004260	metal binding site [ion binding]; metal-binding site
653733004261	dimer interface [polypeptide binding]; other site
653733004262	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
653733004263	dimerization interface [polypeptide binding]; other site
653733004264	putative DNA binding site [nucleotide binding]; other site
653733004265	putative Zn2+ binding site [ion binding]; other site
653733004266	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
653733004267	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
653733004268	inhibitor-cofactor binding pocket; inhibition site
653733004269	pyridoxal 5'-phosphate binding site [chemical binding]; other site
653733004270	catalytic residue [active]
653733004271	Exopolysaccharide synthesis, ExoD; Region: ExoD; pfam06055
653733004272	type II secretion system protein F; Region: GspF; TIGR02120
653733004273	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
653733004274	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
653733004275	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
653733004276	type II secretion system protein E; Region: type_II_gspE; TIGR02533
653733004277	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
653733004278	Walker A motif; other site
653733004279	ATP binding site [chemical binding]; other site
653733004280	Walker B motif; other site
653733004281	type II secretion system protein D; Region: type_II_gspD; TIGR02517
653733004282	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
653733004283	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
653733004284	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
653733004285	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
653733004286	type II secretion system protein C; Region: typeII_sec_gspC; TIGR01713
653733004287	Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356
653733004288	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
653733004289	Type II secretion system (T2SS), protein N; Region: T2SN; pfam01203
653733004290	hypothetical protein; Reviewed; Region: PRK09588
653733004291	Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139
653733004292	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
653733004293	thiamine phosphate binding site [chemical binding]; other site
653733004294	active site
653733004295	pyrophosphate binding site [ion binding]; other site
653733004296	short chain dehydrogenase; Provisional; Region: PRK09134
653733004297	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
653733004298	NAD(P) binding site [chemical binding]; other site
653733004299	active site
653733004300	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
653733004301	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
653733004302	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
653733004303	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
653733004304	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
653733004305	active site
653733004306	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
653733004307	putative active site [active]
653733004308	catalytic residue [active]
653733004309	putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824
653733004310	PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276
653733004311	NAD(P) binding site [chemical binding]; other site
653733004312	EAL domain; Region: EAL; pfam00563
653733004313	HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis.  HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197
653733004314	dimerization interface [polypeptide binding]; other site
653733004315	hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124
653733004316	ATP binding site [chemical binding]; other site
653733004317	hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075
653733004318	hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062
653733004319	HupF/HypC family; Region: HupF_HypC; pfam01455
653733004320	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
653733004321	Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068
653733004322	Acylphosphatase; Region: Acylphosphatase; pfam00708
653733004323	HypF finger; Region: zf-HYPF; pfam07503
653733004324	HypF finger; Region: zf-HYPF; pfam07503
653733004325	Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300
653733004326	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
653733004327	non-specific DNA binding site [nucleotide binding]; other site
653733004328	salt bridge; other site
653733004329	sequence-specific DNA binding site [nucleotide binding]; other site
653733004330	Predicted membrane protein [Function unknown]; Region: COG1971
653733004331	Domain of unknown function DUF; Region: DUF204; pfam02659
653733004332	Domain of unknown function DUF; Region: DUF204; pfam02659
653733004333	Eukaryotic Glutathione Synthetase (eu-GS); catalyses the production of glutathione from gamma-glutamylcysteine and glycine in an ATP-dependent manner. Belongs to the ATP-grasp superfamily; Region: eu-GS; cl00170
653733004334	dimerization unit; other site
653733004335	glutathione (GSH) binding pocket [chemical binding]; other site
653733004336	active site residues [active]
653733004337	ATP binding pocket [chemical binding]; other site
653733004338	magnesium binding site [ion binding]; other site
653733004339	glycine rich loop; other site
653733004340	alanine rich loop; other site
653733004341	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
653733004342	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
653733004343	active site
653733004344	DNA binding site [nucleotide binding]
653733004345	Int/Topo IB signature motif; other site
653733004346	cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673
653733004347	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
653733004348	Walker A/P-loop; other site
653733004349	ATP binding site [chemical binding]; other site
653733004350	Q-loop/lid; other site
653733004351	ABC transporter signature motif; other site
653733004352	Walker B; other site
653733004353	D-loop; other site
653733004354	H-loop/switch region; other site
653733004355	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
653733004356	FtsX-like permease family; Region: FtsX; pfam02687
653733004357	Peptidase family M23; Region: Peptidase_M23; pfam01551
653733004358	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
653733004359	C-terminal peptidase (prc); Region: prc; TIGR00225
653733004360	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
653733004361	protein binding site [polypeptide binding]; other site
653733004362	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
653733004363	Catalytic dyad [active]
653733004364	Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936
653733004365	NodB motif; other site
653733004366	putative active site [active]
653733004367	putative catalytic site [active]
653733004368	Zn binding site [ion binding]; other site
653733004369	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
653733004370	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
653733004371	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
653733004372	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
653733004373	NAD binding site [chemical binding]; other site
653733004374	glucose-6-phosphate isomerase; Provisional; Region: PRK00973
653733004375	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
653733004376	active site
653733004377	dimer interface [polypeptide binding]; other site
653733004378	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
653733004379	dimer interface [polypeptide binding]; other site
653733004380	active site
653733004381	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
653733004382	IHF dimer interface [polypeptide binding]; other site
653733004383	IHF - DNA interface [nucleotide binding]; other site
653733004384	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
653733004385	phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155
653733004386	acyl-activating enzyme (AAE) consensus motif; other site
653733004387	AMP binding site [chemical binding]; other site
653733004388	active site
653733004389	CoA binding site [chemical binding]; other site
653733004390	ACT domain-containing protein [General function prediction only]; Region: COG4747
653733004391	N-terminal ACT domain of a novel protein composed almost entirely of two tandem ACT domains; Region: ACT_Bt0572_1; cd04908
653733004392	C-terminal ACT domain of a novel protein composed of just two ACT domains; Region: ACT_Bt0572_2; cd04882
653733004393	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
653733004394	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
653733004395	active site
653733004396	DNA binding site [nucleotide binding]
653733004397	Int/Topo IB signature motif; other site
653733004398	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
653733004399	ABC1 family; Region: ABC1; cl17513
653733004400	Uncharacterized conserved protein [Function unknown]; Region: COG3937
653733004401	Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509
653733004402	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
653733004403	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
653733004404	SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389
653733004405	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
653733004406	binding surface
653733004407	TPR motif; other site
653733004408	TPR repeat; Region: TPR_11; pfam13414
653733004409	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
653733004410	binding surface
653733004411	TPR motif; other site
653733004412	Tetratricopeptide repeat; Region: TPR_12; pfam13424
653733004413	4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate synthase [Lipid metabolism]; Region: IspE; COG1947
653733004414	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
653733004415	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
653733004416	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
653733004417	S-adenosylmethionine binding site [chemical binding]; other site
653733004418	CHASE2 domain; Region: CHASE2; pfam05226
653733004419	Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252
653733004420	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
653733004421	cyclase homology domain; Region: CHD; cd07302
653733004422	nucleotidyl binding site; other site
653733004423	metal binding site [ion binding]; metal-binding site
653733004424	dimer interface [polypeptide binding]; other site
653733004425	Ferritin-like domain; Region: Ferritin; pfam00210
653733004426	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
653733004427	dinuclear metal binding motif [ion binding]; other site
653733004428	Protein of unknown function (DUF1847); Region: DUF1847; pfam08901
653733004429	Transcriptional regulator [Transcription]; Region: LysR; COG0583
653733004430	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
653733004431	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
653733004432	dimerization interface [polypeptide binding]; other site
653733004433	Protein of unknown function (DUF1228); Region: DUF1228; pfam06779
653733004434	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491
653733004435	active site 1 [active]
653733004436	dimer interface [polypeptide binding]; other site
653733004437	hexamer interface [polypeptide binding]; other site
653733004438	active site 2 [active]
653733004439	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
653733004440	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
653733004441	active site
653733004442	phosphorylation site [posttranslational modification]
653733004443	intermolecular recognition site; other site
653733004444	dimerization interface [polypeptide binding]; other site
653733004445	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
653733004446	Walker A motif; other site
653733004447	ATP binding site [chemical binding]; other site
653733004448	Walker B motif; other site
653733004449	arginine finger; other site
653733004450	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
653733004451	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
653733004452	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
653733004453	putative dimer interface [polypeptide binding]; other site
653733004454	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
653733004455	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
653733004456	putative dimer interface [polypeptide binding]; other site
653733004457	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
653733004458	active site
653733004459	Protein of unknown function (DUF1015); Region: DUF1015; pfam06245
653733004460	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
653733004461	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
653733004462	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
653733004463	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
653733004464	PAS domain S-box; Region: sensory_box; TIGR00229
653733004465	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
653733004466	putative active site [active]
653733004467	heme pocket [chemical binding]; other site
653733004468	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
653733004469	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
653733004470	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
653733004471	ABC transporter; Region: ABC_tran_2; pfam12848
653733004472	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
653733004473	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
653733004474	dimerization interface [polypeptide binding]; other site
653733004475	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
653733004476	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
653733004477	dimer interface [polypeptide binding]; other site
653733004478	putative CheW interface [polypeptide binding]; other site
653733004479	Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729
653733004480	Rubredoxin; Region: Rubredoxin; pfam00301
653733004481	iron binding site [ion binding]; other site
653733004482	rubrerythrin-like, diiron-binding domain; Region: Rubrerythrin_like; cd01046
653733004483	Rubrerythrin [Energy production and conversion]; Region: COG1592
653733004484	diiron binding motif [ion binding]; other site
653733004485	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542
653733004486	Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474
653733004487	Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014
653733004488	Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485
653733004489	Surface antigen; Region: Bac_surface_Ag; pfam01103
653733004490	desulfoferrodoxin; Region: dfx_rbo; TIGR00320
653733004491	Desulforedoxin (DSRD) domain; a small non-heme iron domain present in the desulforedoxin (rubredoxin oxidoreductase) and desulfoferrodoxin proteins of some archeael and bacterial methanogens and sulfate/sulfur reducers. Desulforedoxin is a small; Region: DSRD; cd00974
653733004492	non-heme iron binding site [ion binding]; other site
653733004493	dimer interface [polypeptide binding]; other site
653733004494	Superoxide reductase-like (SORL) domain, class I; SORL-domains are present in a family of mononuclear non-heme iron proteins that includes superoxide reductase and desulfoferrodoxin.  Superoxide reductase-like proteins scavenge superoxide anion radicals...; Region: SORL_Dfx_classI; cd03171
653733004495	non-heme iron binding site [ion binding]; other site
653733004496	dimer interface [polypeptide binding]; other site
653733004497	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
653733004498	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
653733004499	dimer interface [polypeptide binding]; other site
653733004500	putative anticodon binding site; other site
653733004501	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
653733004502	motif 1; other site
653733004503	active site
653733004504	motif 2; other site
653733004505	motif 3; other site
653733004506	hypothetical protein; Provisional; Region: PRK04164
653733004507	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
653733004508	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
653733004509	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
653733004510	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
653733004511	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
653733004512	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
653733004513	purine monophosphate binding site [chemical binding]; other site
653733004514	dimer interface [polypeptide binding]; other site
653733004515	putative catalytic residues [active]
653733004516	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
653733004517	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
653733004518	Restriction endonuclease; Region: Mrr_cat; pfam04471
653733004519	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
653733004520	putative binding surface; other site
653733004521	active site
653733004522	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
653733004523	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
653733004524	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
653733004525	ATP binding site [chemical binding]; other site
653733004526	Mg2+ binding site [ion binding]; other site
653733004527	G-X-G motif; other site
653733004528	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
653733004529	chemotaxis regulatory protein CheY; Provisional; Region: PRK10610
653733004530	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
653733004531	active site
653733004532	phosphorylation site [posttranslational modification]
653733004533	intermolecular recognition site; other site
653733004534	dimerization interface [polypeptide binding]; other site
653733004535	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
653733004536	rod shape-determining protein MreB; Provisional; Region: PRK13930
653733004537	nucleotide binding site [chemical binding]; other site
653733004538	Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776
653733004539	flagellar motor switch protein FliN; Region: fliN; TIGR02480
653733004540	flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666
653733004541	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
653733004542	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
653733004543	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
653733004544	active site
653733004545	phosphorylation site [posttranslational modification]
653733004546	intermolecular recognition site; other site
653733004547	dimerization interface [polypeptide binding]; other site
653733004548	CheB methylesterase; Region: CheB_methylest; pfam01339
653733004549	RNA polymerase sigma factor, FliA/WhiG family; Region: FliA_WhiG; TIGR02479
653733004550	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
653733004551	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
653733004552	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
653733004553	DNA binding residues [nucleotide binding]
653733004554	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
653733004555	FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038
653733004556	P-loop; other site
653733004557	flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703
653733004558	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
653733004559	flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012
653733004560	FHIPEP family; Region: FHIPEP; pfam00771
653733004561	flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702
653733004562	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257
653733004563	flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701
653733004564	flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700
653733004565	flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699
653733004566	Surface presentation of antigens (SPOA); Region: SpoA; cl00819
653733004567	Flagellar basal body-associated protein FliL; Region: FliL; cl00681
653733004568	Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360
653733004569	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
653733004570	ligand binding site [chemical binding]; other site
653733004571	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
653733004572	flagellar motor protein MotP; Reviewed; Region: PRK06926
653733004573	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
653733004574	PLD-like domain; Region: PLDc_2; pfam13091
653733004575	putative active site [active]
653733004576	catalytic site [active]
653733004577	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
653733004578	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
653733004579	active site
653733004580	phosphorylation site [posttranslational modification]
653733004581	intermolecular recognition site; other site
653733004582	dimerization interface [polypeptide binding]; other site
653733004583	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
653733004584	Walker A motif; other site
653733004585	ATP binding site [chemical binding]; other site
653733004586	Walker B motif; other site
653733004587	arginine finger; other site
653733004588	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
653733004589	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
653733004590	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
653733004591	putative active site [active]
653733004592	heme pocket [chemical binding]; other site
653733004593	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
653733004594	dimer interface [polypeptide binding]; other site
653733004595	phosphorylation site [posttranslational modification]
653733004596	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
653733004597	ATP binding site [chemical binding]; other site
653733004598	Mg2+ binding site [ion binding]; other site
653733004599	G-X-G motif; other site
653733004600	Transglycosylase; Region: Transgly; pfam00912
653733004601	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
653733004602	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
653733004603	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257
653733004604	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
653733004605	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
653733004606	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
653733004607	dimer interface [polypeptide binding]; other site
653733004608	motif 1; other site
653733004609	active site
653733004610	motif 2; other site
653733004611	motif 3; other site
653733004612	Recombinational DNA repair protein (RecF pathway) [DNA replication, recombination, and repair]; Region: RecO; COG1381
653733004613	GTPase Era; Reviewed; Region: era; PRK00089
653733004614	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
653733004615	G1 box; other site
653733004616	GTP/Mg2+ binding site [chemical binding]; other site
653733004617	Switch I region; other site
653733004618	G2 box; other site
653733004619	Switch II region; other site
653733004620	G3 box; other site
653733004621	G4 box; other site
653733004622	G5 box; other site
653733004623	KH domain; Region: KH_2; pfam07650
653733004624	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
653733004625	Domain of unknown function DUF21; Region: DUF21; pfam01595
653733004626	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
653733004627	Transporter associated domain; Region: CorC_HlyC; smart01091
653733004628	Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130
653733004629	glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810
653733004630	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
653733004631	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
653733004632	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
653733004633	active site
653733004634	dimer interface [polypeptide binding]; other site
653733004635	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
653733004636	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
653733004637	active site
653733004638	FMN binding site [chemical binding]; other site
653733004639	substrate binding site [chemical binding]; other site
653733004640	3Fe-4S cluster binding site [ion binding]; other site
653733004641	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
653733004642	domain interface; other site
653733004643	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
653733004644	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
653733004645	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
653733004646	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
653733004647	dimer interface [polypeptide binding]; other site
653733004648	putative CheW interface [polypeptide binding]; other site
653733004649	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
653733004650	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
653733004651	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
653733004652	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
653733004653	Ligand binding site [chemical binding]; other site
653733004654	Electron transfer flavoprotein domain; Region: ETF; pfam01012
653733004655	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
653733004656	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
653733004657	Cysteine-rich domain; Region: CCG; pfam02754
653733004658	Cysteine-rich domain; Region: CCG; pfam02754
653733004659	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
653733004660	Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158
653733004661	FAD binding site [chemical binding]; other site
653733004662	homotetramer interface [polypeptide binding]; other site
653733004663	substrate binding pocket [chemical binding]; other site
653733004664	catalytic base [active]
653733004665	3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809
653733004666	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
653733004667	substrate binding site [chemical binding]; other site
653733004668	oxyanion hole (OAH) forming residues; other site
653733004669	trimer interface [polypeptide binding]; other site
653733004670	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808
653733004671	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
653733004672	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
653733004673	putative acyltransferase; Provisional; Region: PRK05790
653733004674	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
653733004675	dimer interface [polypeptide binding]; other site
653733004676	active site
653733004677	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
653733004678	Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592
653733004679	DNA binding residues [nucleotide binding]
653733004680	dimer interface [polypeptide binding]; other site
653733004681	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
653733004682	active site
653733004683	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
653733004684	CoenzymeA binding site [chemical binding]; other site
653733004685	subunit interaction site [polypeptide binding]; other site
653733004686	PHB binding site; other site
653733004687	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
653733004688	mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997
653733004689	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803
653733004690	active site
653733004691	FMN binding site [chemical binding]; other site
653733004692	substrate binding site [chemical binding]; other site
653733004693	putative catalytic residue [active]
653733004694	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
653733004695	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
653733004696	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
653733004697	active site
653733004698	acetyl-CoA acetyltransferase; Provisional; Region: PRK09052
653733004699	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
653733004700	dimer interface [polypeptide binding]; other site
653733004701	active site
653733004702	3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250
653733004703	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
653733004704	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
653733004705	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
653733004706	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
653733004707	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
653733004708	substrate binding site [chemical binding]; other site
653733004709	oxyanion hole (OAH) forming residues; other site
653733004710	trimer interface [polypeptide binding]; other site
653733004711	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
653733004712	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
653733004713	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
653733004714	acyl-activating enzyme (AAE) consensus motif; other site
653733004715	putative AMP binding site [chemical binding]; other site
653733004716	putative active site [active]
653733004717	putative CoA binding site [chemical binding]; other site
653733004718	Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; pfam03349
653733004719	Helix-turn-helix domain; Region: HTH_17; pfam12728
653733004720	Initiator Replication protein; Region: Rep_3; cl17676
653733004721	phage-associated protein, BcepMu gp16 family; Region: BcepMu_gp16; TIGR04111
653733004722	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
653733004723	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
653733004724	non-specific DNA binding site [nucleotide binding]; other site
653733004725	salt bridge; other site
653733004726	sequence-specific DNA binding site [nucleotide binding]; other site
653733004727	Prophage antirepressor [Transcription]; Region: COG3617
653733004728	BRO family, N-terminal domain; Region: Bro-N; smart01040
653733004729	type I restriction enzyme EcoKI subunit R; Provisional; Region: hsdR; PRK11448
653733004730	Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227
653733004731	Domain of unknown function (DUF1738); Region: DUF1738; pfam08401
653733004732	TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375
653733004733	AAA-like domain; Region: AAA_10; pfam12846
653733004734	Protein of unknown function (DUF3800); Region: DUF3800; pfam12686
653733004735	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
653733004736	active site
653733004737	catalytic residues [active]
653733004738	DNA binding site [nucleotide binding]
653733004739	Int/Topo IB signature motif; other site
653733004740	Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227
653733004741	Mg binding site [ion binding]; other site
653733004742	nucleotide binding site [chemical binding]; other site
653733004743	putative protofilament interface [polypeptide binding]; other site
653733004744	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
653733004745	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
653733004746	cofactor binding site; other site
653733004747	DNA binding site [nucleotide binding]
653733004748	substrate interaction site [chemical binding]; other site
653733004749	TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375
653733004750	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
653733004751	ligand binding site [chemical binding]; other site
653733004752	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
653733004753	TraE protein; Region: TraE; cl05060
653733004754	TraK protein; Region: TraK; pfam06586
653733004755	Bacterial conjugation TrbI-like protein; Region: TrbI; cl04242
653733004756	F pilus assembly Type-IV secretion system for plasmid transfer; Region: TraC_F_IV; pfam11130
653733004757	type-IV secretion system protein TraC; Region: TraC-F-type; TIGR02746
653733004758	CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135
653733004759	conjugal transfer mating pair stabilization protein TraN; Reviewed; Region: PRK12355
653733004760	Type-F conjugative transfer system pilin assembly protein; Region: TrbC_Ftype; cl09883
653733004761	PAS domain; Region: PAS_9; pfam13426
653733004762	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
653733004763	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
653733004764	metal binding site [ion binding]; metal-binding site
653733004765	active site
653733004766	I-site; other site
653733004767	Domain of unknown function (DUF3391); Region: DUF3391; pfam11871
653733004768	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
653733004769	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
653733004770	Zn2+ binding site [ion binding]; other site
653733004771	Mg2+ binding site [ion binding]; other site
653733004772	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
653733004773	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
653733004774	dimer interface [polypeptide binding]; other site
653733004775	ssDNA binding site [nucleotide binding]; other site
653733004776	tetramer (dimer of dimers) interface [polypeptide binding]; other site
653733004777	Putative exonuclease, RdgC; Region: RdgC; cl01122
653733004778	hypothetical protein; Provisional; Region: PHA03375
653733004779	Signal peptidase, peptidase S26; Region: Peptidase_S26; pfam10502
653733004780	conjugal transfer pilin processing protease TraF; Provisional; Region: PRK13838
653733004781	Sex factor F TraW protein N terminal; Region: TraW_N; cl10149
653733004782	TraU protein; Region: TraU; pfam06834
653733004783	F plasmid transfer operon protein; Region: TraF; pfam13728
653733004784	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
653733004785	catalytic residues [active]
653733004786	Conjugative relaxosome accessory transposon protein; Region: TraH; cl05580
653733004787	TraG-like protein, N-terminal region; Region: TraG_N; pfam07916
653733004788	Protein of unknown function (DUF2726); Region: DUF2726; pfam10881
653733004789	BRO family, N-terminal domain; Region: Bro-N; smart01040
653733004790	Prophage antirepressor [Transcription]; Region: COG3617
653733004791	BRO family, N-terminal domain; Region: Bro-N; smart01040
653733004792	AntA/AntB antirepressor; Region: AntA; cl01430
653733004793	Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542
653733004794	Transposase; Region: DDE_Tnp_ISL3; pfam01610
653733004795	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338
653733004796	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
653733004797	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
653733004798	catalytic residues [active]
653733004799	catalytic nucleophile [active]
653733004800	Presynaptic Site I dimer interface [polypeptide binding]; other site
653733004801	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
653733004802	Synaptic Flat tetramer interface [polypeptide binding]; other site
653733004803	Synaptic Site I dimer interface [polypeptide binding]; other site
653733004804	DNA binding site [nucleotide binding]
653733004805	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
653733004806	DNA-binding interface [nucleotide binding]; DNA binding site
653733004807	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
653733004808	MarR family; Region: MarR_2; pfam12802
653733004809	Endonuclease I [DNA replication, recombination, and repair]; Region: EndA; COG2356
653733004810	DNA-specific endonuclease I; Provisional; Region: PRK15137
653733004811	SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974
653733004812	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
653733004813	Catalytic site [active]
653733004814	DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609
653733004815	umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700
653733004816	active site
653733004817	DNA binding site [nucleotide binding]
653733004818	Domain of unknown function (DUF4113); Region: DUF4113; pfam13438
653733004819	integrase; Provisional; Region: PRK09692
653733004820	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
653733004821	active site
653733004822	Int/Topo IB signature motif; other site
653733004823	bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759
653733004824	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
653733004825	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
653733004826	metal binding site [ion binding]; metal-binding site
653733004827	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
653733004828	Mechanosensitive ion channel; Region: MS_channel; pfam00924
653733004829	Protein of unknown function (DUF432); Region: DUF432; cl01027
653733004830	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
653733004831	Zn2+ binding site [ion binding]; other site
653733004832	Mg2+ binding site [ion binding]; other site
653733004833	Hemerythrin; Region: Hemerythrin; cd12107
653733004834	Fe binding site [ion binding]; other site
653733004835	phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261
653733004836	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
653733004837	solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336
653733004838	Na2 binding site [ion binding]; other site
653733004839	putative substrate binding site 1 [chemical binding]; other site
653733004840	Na binding site 1 [ion binding]; other site
653733004841	putative substrate binding site 2 [chemical binding]; other site
653733004842	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
653733004843	Ligand Binding Site [chemical binding]; other site
653733004844	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
653733004845	Ligand Binding Site [chemical binding]; other site
653733004846	Protein of unknown function (DUF342); Region: DUF342; pfam03961
653733004847	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
653733004848	Response regulator receiver domain; Region: Response_reg; pfam00072
653733004849	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
653733004850	active site
653733004851	phosphorylation site [posttranslational modification]
653733004852	intermolecular recognition site; other site
653733004853	dimerization interface [polypeptide binding]; other site
653733004854	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
653733004855	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
653733004856	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
653733004857	putative acyl-acceptor binding pocket; other site
653733004858	Lysis protein; Region: Lysis_col; pfam02402
653733004859	Bacterial SH3 domain; Region: SH3_4; pfam06347
653733004860	Bacterial SH3 domain; Region: SH3_4; pfam06347
653733004861	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
653733004862	Flagellar basal body protein FlaE; Region: FlaE; pfam07559
653733004863	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
653733004864	Flagellar hook capping protein [Cell motility and secretion]; Region: FlgD; COG1843
653733004865	Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963
653733004866	FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861
653733004867	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
653733004868	ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757
653733004869	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
653733004870	homodimer interface [polypeptide binding]; other site
653733004871	oligonucleotide binding site [chemical binding]; other site
653733004872	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
653733004873	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
653733004874	tandem repeat interface [polypeptide binding]; other site
653733004875	oligomer interface [polypeptide binding]; other site
653733004876	active site residues [active]
653733004877	thiamine biosynthesis protein ThiC; Region: thiC; TIGR00190
653733004878	ThiC family; Region: ThiC; pfam01964
653733004879	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
653733004880	thiS-thiF/thiG interaction site; other site
653733004881	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
653733004882	ThiS interaction site; other site
653733004883	putative active site [active]
653733004884	tetramer interface [polypeptide binding]; other site
653733004885	thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240
653733004886	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
653733004887	FeS/SAM binding site; other site
653733004888	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
653733004889	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
653733004890	MarR family; Region: MarR; pfam01047
653733004891	Uncharacterized BCR, COG1636; Region: DUF208; pfam02677
653733004892	Esterase/lipase [General function prediction only]; Region: COG1647
653733004893	Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229; cl15841
653733004894	SelR domain; Region: SelR; pfam01641
653733004895	carboxynorspermidine decarboxylase; Region: nspC; TIGR01047
653733004896	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829
653733004897	dimer interface [polypeptide binding]; other site
653733004898	active site
653733004899	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
653733004900	catalytic residues [active]
653733004901	substrate binding site [chemical binding]; other site
653733004902	Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748
653733004903	lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376
653733004904	lipoprotein signal peptidase; Provisional; Region: PRK14787
653733004905	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
653733004906	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
653733004907	active site
653733004908	HIGH motif; other site
653733004909	nucleotide binding site [chemical binding]; other site
653733004910	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
653733004911	active site
653733004912	KMSKS motif; other site
653733004913	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
653733004914	tRNA binding surface [nucleotide binding]; other site
653733004915	anticodon binding site; other site
653733004916	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
653733004917	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399
653733004918	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
653733004919	active site
653733004920	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
653733004921	Septum formation initiator; Region: DivIC; pfam04977
653733004922	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
653733004923	The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757
653733004924	active site
653733004925	substrate binding site [chemical binding]; other site
653733004926	metal binding site [ion binding]; metal-binding site
653733004927	Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740
653733004928	dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037
653733004929	heterodimer interface [polypeptide binding]; other site
653733004930	active site
653733004931	FMN binding site [chemical binding]; other site
653733004932	homodimer interface [polypeptide binding]; other site
653733004933	substrate binding site [chemical binding]; other site
653733004934	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
653733004935	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
653733004936	RNA binding surface [nucleotide binding]; other site
653733004937	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
653733004938	active site
653733004939	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
653733004940	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
653733004941	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
653733004942	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
653733004943	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
653733004944	binding surface
653733004945	TPR motif; other site
653733004946	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
653733004947	active site
653733004948	EVE domain; Region: EVE; cl00728
653733004949	HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228
653733004950	PAS domain S-box; Region: sensory_box; TIGR00229
653733004951	PAS domain S-box; Region: sensory_box; TIGR00229
653733004952	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
653733004953	putative active site [active]
653733004954	heme pocket [chemical binding]; other site
653733004955	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
653733004956	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
653733004957	ATP binding site [chemical binding]; other site
653733004958	Mg2+ binding site [ion binding]; other site
653733004959	G-X-G motif; other site
653733004960	Response regulator receiver domain; Region: Response_reg; pfam00072
653733004961	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
653733004962	active site
653733004963	phosphorylation site [posttranslational modification]
653733004964	intermolecular recognition site; other site
653733004965	dimerization interface [polypeptide binding]; other site
653733004966	NMT1/THI5 like; Region: NMT1; pfam09084
653733004967	PAS domain S-box; Region: sensory_box; TIGR00229
653733004968	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
653733004969	putative active site [active]
653733004970	heme pocket [chemical binding]; other site
653733004971	nitrogen fixation negative regulator NifL; Region: nifL_nitrog; TIGR02938
653733004972	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
653733004973	putative active site [active]
653733004974	heme pocket [chemical binding]; other site
653733004975	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
653733004976	putative active site [active]
653733004977	heme pocket [chemical binding]; other site
653733004978	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
653733004979	ATP binding site [chemical binding]; other site
653733004980	Mg2+ binding site [ion binding]; other site
653733004981	G-X-G motif; other site
653733004982	Response regulator receiver domain; Region: Response_reg; pfam00072
653733004983	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
653733004984	active site
653733004985	phosphorylation site [posttranslational modification]
653733004986	intermolecular recognition site; other site
653733004987	dimerization interface [polypeptide binding]; other site
653733004988	Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275
653733004989	5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694
653733004990	GAF domain; Region: GAF_3; pfam13492
653733004991	Histidine kinase; Region: His_kinase; pfam06580
653733004992	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
653733004993	ATP binding site [chemical binding]; other site
653733004994	Mg2+ binding site [ion binding]; other site
653733004995	G-X-G motif; other site
653733004996	Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435
653733004997	Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409
653733004998	C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190
653733004999	putative dimer interface [polypeptide binding]; other site
653733005000	N-terminal domain interface [polypeptide binding]; other site
653733005001	putative substrate binding pocket (H-site) [chemical binding]; other site
653733005002	Cytochrome c; Region: Cytochrom_C; cl11414
653733005003	endonuclease IV; Provisional; Region: PRK01060
653733005004	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
653733005005	AP (apurinic/apyrimidinic) site pocket; other site
653733005006	DNA interaction; other site
653733005007	Metal-binding active site; metal-binding site
653733005008	fumarate hydratase; Reviewed; Region: fumC; PRK00485
653733005009	Class II fumarases; Region: Fumarase_classII; cd01362
653733005010	active site
653733005011	tetramer interface [polypeptide binding]; other site
653733005012	DNA repair protein RadA; Provisional; Region: PRK11823
653733005013	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
653733005014	Walker A motif; other site
653733005015	ATP binding site [chemical binding]; other site
653733005016	Walker B motif; other site
653733005017	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
653733005018	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
653733005019	formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583
653733005020	Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033
653733005021	4Fe-4S dicluster domain; Region: Fer4_11; pfam13247
653733005022	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
653733005023	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
653733005024	Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283
653733005025	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
653733005026	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
653733005027	PhoU domain; Region: PhoU; pfam01895
653733005028	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
653733005029	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
653733005030	dimer interface [polypeptide binding]; other site
653733005031	phosphorylation site [posttranslational modification]
653733005032	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
653733005033	ATP binding site [chemical binding]; other site
653733005034	Mg2+ binding site [ion binding]; other site
653733005035	G-X-G motif; other site
653733005036	Response regulator receiver domain; Region: Response_reg; pfam00072
653733005037	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
653733005038	active site
653733005039	phosphorylation site [posttranslational modification]
653733005040	intermolecular recognition site; other site
653733005041	dimerization interface [polypeptide binding]; other site
653733005042	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
653733005043	metal binding site [ion binding]; metal-binding site
653733005044	active site
653733005045	I-site; other site
653733005046	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
653733005047	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
653733005048	S-adenosylmethionine binding site [chemical binding]; other site
653733005049	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_22; cd08359
653733005050	putative dimer interface [polypeptide binding]; other site
653733005051	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
653733005052	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
653733005053	Ligand Binding Site [chemical binding]; other site
653733005054	Uncharacterized conserved protein [Function unknown]; Region: COG2928
653733005055	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
653733005056	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
653733005057	putative acyl-acceptor binding pocket; other site
653733005058	Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444
653733005059	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
653733005060	translation initiation factor IF-2; Region: IF-2; TIGR00487
653733005061	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
653733005062	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
653733005063	G1 box; other site
653733005064	putative GEF interaction site [polypeptide binding]; other site
653733005065	GTP/Mg2+ binding site [chemical binding]; other site
653733005066	Switch I region; other site
653733005067	G2 box; other site
653733005068	G3 box; other site
653733005069	Switch II region; other site
653733005070	G4 box; other site
653733005071	G5 box; other site
653733005072	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
653733005073	Translation-initiation factor 2; Region: IF-2; pfam11987
653733005074	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
653733005075	Protein of unknown function (DUF448); Region: DUF448; pfam04296
653733005076	putative RNA binding cleft [nucleotide binding]; other site
653733005077	Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600
653733005078	transcription termination factor NusA; Region: NusA; TIGR01953
653733005079	NusA N-terminal domain; Region: NusA_N; pfam08529
653733005080	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
653733005081	RNA binding site [nucleotide binding]; other site
653733005082	homodimer interface [polypeptide binding]; other site
653733005083	NusA-like KH domain; Region: KH_5; pfam13184
653733005084	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
653733005085	G-X-X-G motif; other site
653733005086	Sm and related proteins; Region: Sm_like; cl00259
653733005087	ribosome maturation protein RimP; Reviewed; Region: PRK00092
653733005088	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
653733005089	putative oligomer interface [polypeptide binding]; other site
653733005090	putative RNA binding site [nucleotide binding]; other site
653733005091	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
653733005092	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
653733005093	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
653733005094	ligand binding site [chemical binding]; other site
653733005095	tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800
653733005096	TolB amino-terminal domain; Region: TolB_N; pfam04052
653733005097	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
653733005098	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
653733005099	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
653733005100	Gram-negative bacterial tonB protein; Region: TonB; cl10048
653733005101	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
653733005102	TolR protein; Region: tolR; TIGR02801
653733005103	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
653733005104	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
653733005105	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
653733005106	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
653733005107	active site
653733005108	elongation factor P; Validated; Region: PRK00529
653733005109	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
653733005110	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
653733005111	RNA binding site [nucleotide binding]; other site
653733005112	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
653733005113	RNA binding site [nucleotide binding]; other site
653733005114	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
653733005115	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
653733005116	carboxyltransferase (CT) interaction site; other site
653733005117	biotinylation site [posttranslational modification]; other site
653733005118	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
653733005119	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
653733005120	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
653733005121	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
653733005122	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323
653733005123	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
653733005124	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
653733005125	active site
653733005126	catalytic residues [active]
653733005127	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
653733005128	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
653733005129	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
653733005130	Zn2+ binding site [ion binding]; other site
653733005131	Mg2+ binding site [ion binding]; other site
653733005132	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
653733005133	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
653733005134	acyl-activating enzyme (AAE) consensus motif; other site
653733005135	putative AMP binding site [chemical binding]; other site
653733005136	putative active site [active]
653733005137	putative CoA binding site [chemical binding]; other site
653733005138	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
653733005139	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
653733005140	active site
653733005141	phosphorylation site [posttranslational modification]
653733005142	intermolecular recognition site; other site
653733005143	dimerization interface [polypeptide binding]; other site
653733005144	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
653733005145	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
653733005146	dimer interface [polypeptide binding]; other site
653733005147	phosphorylation site [posttranslational modification]
653733005148	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
653733005149	ATP binding site [chemical binding]; other site
653733005150	G-X-G motif; other site
653733005151	multidrug efflux protein; Reviewed; Region: PRK01766
653733005152	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131
653733005153	cation binding site [ion binding]; other site
653733005154	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
653733005155	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
653733005156	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
653733005157	trmE is a tRNA modification GTPase; Region: trmE; cd04164
653733005158	G1 box; other site
653733005159	GTP/Mg2+ binding site [chemical binding]; other site
653733005160	Switch I region; other site
653733005161	G2 box; other site
653733005162	Switch II region; other site
653733005163	G3 box; other site
653733005164	G4 box; other site
653733005165	G5 box; other site
653733005166	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
653733005167	DNA gyrase subunit A; Validated; Region: PRK05560
653733005168	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
653733005169	CAP-like domain; other site
653733005170	active site
653733005171	primary dimer interface [polypeptide binding]; other site
653733005172	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
653733005173	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
653733005174	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
653733005175	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
653733005176	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
653733005177	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
653733005178	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
653733005179	MutS domain I; Region: MutS_I; pfam01624
653733005180	MutS domain III; Region: MutS_III; pfam05192
653733005181	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
653733005182	Walker A/P-loop; other site
653733005183	ATP binding site [chemical binding]; other site
653733005184	Q-loop/lid; other site
653733005185	ABC transporter signature motif; other site
653733005186	Walker B; other site
653733005187	D-loop; other site
653733005188	H-loop/switch region; other site
653733005189	Response regulator receiver domain; Region: Response_reg; pfam00072
653733005190	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
653733005191	active site
653733005192	phosphorylation site [posttranslational modification]
653733005193	intermolecular recognition site; other site
653733005194	dimerization interface [polypeptide binding]; other site
653733005195	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
653733005196	putative CheA interaction surface; other site
653733005197	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
653733005198	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
653733005199	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
653733005200	dimer interface [polypeptide binding]; other site
653733005201	putative CheW interface [polypeptide binding]; other site
653733005202	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
653733005203	putative binding surface; other site
653733005204	active site
653733005205	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
653733005206	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
653733005207	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
653733005208	ATP binding site [chemical binding]; other site
653733005209	Mg2+ binding site [ion binding]; other site
653733005210	G-X-G motif; other site
653733005211	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
653733005212	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
653733005213	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
653733005214	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
653733005215	S-adenosylmethionine binding site [chemical binding]; other site
653733005216	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
653733005217	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
653733005218	ATP binding site [chemical binding]; other site
653733005219	Mg2+ binding site [ion binding]; other site
653733005220	G-X-G motif; other site
653733005221	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
653733005222	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
653733005223	active site
653733005224	HIGH motif; other site
653733005225	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
653733005226	KMSKS motif; other site
653733005227	Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963
653733005228	tRNA binding surface [nucleotide binding]; other site
653733005229	anticodon binding site; other site
653733005230	YceG-like family; Region: YceG; pfam02618
653733005231	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
653733005232	dimerization interface [polypeptide binding]; other site
653733005233	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
653733005234	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
653733005235	N-terminal plug; other site
653733005236	ligand-binding site [chemical binding]; other site
653733005237	vitamin B12-transporter protein BtuF; Provisional; Region: PRK03379
653733005238	Cobalamin binding protein BtuF.  These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species.  They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144
653733005239	cobalamin binding residues [chemical binding]; other site
653733005240	putative BtuC binding residues; other site
653733005241	dimer interface [polypeptide binding]; other site
653733005242	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
653733005243	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
653733005244	dimer interface [polypeptide binding]; other site
653733005245	putative PBP binding regions; other site
653733005246	ABC-ATPase subunit  interface; other site
653733005247	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
653733005248	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
653733005249	Walker A/P-loop; other site
653733005250	ATP binding site [chemical binding]; other site
653733005251	Q-loop/lid; other site
653733005252	ABC transporter signature motif; other site
653733005253	Walker B; other site
653733005254	D-loop; other site
653733005255	H-loop/switch region; other site
653733005256	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
653733005257	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
653733005258	Uncharacterized conserved protein [Function unknown]; Region: COG3777
653733005259	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
653733005260	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
653733005261	active site 2 [active]
653733005262	active site 1 [active]
653733005263	hypothetical protein; Provisional; Region: PRK06815
653733005264	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
653733005265	tetramer interface [polypeptide binding]; other site
653733005266	pyridoxal 5'-phosphate binding site [chemical binding]; other site
653733005267	catalytic residue [active]
653733005268	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
653733005269	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
653733005270	Ligand Binding Site [chemical binding]; other site
653733005271	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
653733005272	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
653733005273	active site
653733005274	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
653733005275	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
653733005276	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
653733005277	homodimer interface [polypeptide binding]; other site
653733005278	substrate-cofactor binding pocket; other site
653733005279	catalytic residue [active]
653733005280	Response regulator receiver domain; Region: Response_reg; pfam00072
653733005281	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
653733005282	active site
653733005283	phosphorylation site [posttranslational modification]
653733005284	intermolecular recognition site; other site
653733005285	dimerization interface [polypeptide binding]; other site
653733005286	PAS domain; Region: PAS_8; pfam13188
653733005287	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
653733005288	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
653733005289	metal binding site [ion binding]; metal-binding site
653733005290	active site
653733005291	I-site; other site
653733005292	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
653733005293	MiaB-like tRNA modifying enzyme; Region: MiaB-like-C; TIGR01579
653733005294	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
653733005295	FeS/SAM binding site; other site
653733005296	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
653733005297	outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303
653733005298	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
653733005299	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
653733005300	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
653733005301	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
653733005302	Surface antigen; Region: Bac_surface_Ag; pfam01103
653733005303	Outer membrane protein (OmpH-like); Region: OmpH; pfam03938
653733005304	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
653733005305	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
653733005306	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
653733005307	trimer interface [polypeptide binding]; other site
653733005308	active site
653733005309	UDP-GlcNAc binding site [chemical binding]; other site
653733005310	lipid binding site [chemical binding]; lipid-binding site
653733005311	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
653733005312	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
653733005313	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
653733005314	active site
653733005315	Protein of unknown function (DUF1009); Region: DUF1009; pfam06230
653733005316	Exonuclease VII small subunit; Region: Exonuc_VII_S; pfam02609
653733005317	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
653733005318	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
653733005319	substrate binding pocket [chemical binding]; other site
653733005320	chain length determination region; other site
653733005321	substrate-Mg2+ binding site; other site
653733005322	catalytic residues [active]
653733005323	aspartate-rich region 1; other site
653733005324	active site lid residues [active]
653733005325	aspartate-rich region 2; other site
653733005326	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
653733005327	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
653733005328	TPP-binding site; other site
653733005329	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
653733005330	PYR/PP interface [polypeptide binding]; other site
653733005331	dimer interface [polypeptide binding]; other site
653733005332	TPP binding site [chemical binding]; other site
653733005333	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
653733005334	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
653733005335	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
653733005336	DHH family; Region: DHH; pfam01368
653733005337	tRNA pseudouridine(55) synthase; Region: TruB; TIGR00431
653733005338	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
653733005339	RNA binding site [nucleotide binding]; other site
653733005340	active site
653733005341	dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054
653733005342	FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218
653733005343	FAD binding pocket [chemical binding]; other site
653733005344	FAD binding motif [chemical binding]; other site
653733005345	phosphate binding motif [ion binding]; other site
653733005346	beta-alpha-beta structure motif; other site
653733005347	NAD binding pocket [chemical binding]; other site
653733005348	Iron coordination center [ion binding]; other site
653733005349	K+-dependent Na+/Ca+ exchanger related-protein; Region: TIGR00367
653733005350	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
653733005351	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
653733005352	SurA N-terminal domain; Region: SurA_N_3; cl07813
653733005353	PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145
653733005354	DNA polymerase I; Provisional; Region: PRK05755
653733005355	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
653733005356	active site
653733005357	metal binding site 1 [ion binding]; metal-binding site
653733005358	putative 5' ssDNA interaction site; other site
653733005359	metal binding site 3; metal-binding site
653733005360	metal binding site 2 [ion binding]; metal-binding site
653733005361	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
653733005362	putative DNA binding site [nucleotide binding]; other site
653733005363	putative metal binding site [ion binding]; other site
653733005364	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
653733005365	active site
653733005366	catalytic site [active]
653733005367	substrate binding site [chemical binding]; other site
653733005368	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
653733005369	active site
653733005370	DNA binding site [nucleotide binding]
653733005371	catalytic site [active]
653733005372	para-aminobenzoate synthase component I; Validated; Region: PRK07093
653733005373	PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224
653733005374	substrate-cofactor binding pocket; other site
653733005375	pyridoxal 5'-phosphate binding site [chemical binding]; other site
653733005376	catalytic residue [active]
653733005377	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
653733005378	Uncharacterized ArCR, COG2043; Region: DUF169; cl00894
653733005379	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562
653733005380	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
653733005381	homodimer interface [polypeptide binding]; other site
653733005382	metal binding site [ion binding]; metal-binding site
653733005383	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
653733005384	homodimer interface [polypeptide binding]; other site
653733005385	active site
653733005386	putative chemical substrate binding site [chemical binding]; other site
653733005387	metal binding site [ion binding]; metal-binding site
653733005388	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
653733005389	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
653733005390	active site
653733005391	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
653733005392	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
653733005393	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
653733005394	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
653733005395	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
653733005396	minor groove reading motif; other site
653733005397	helix-hairpin-helix signature motif; other site
653733005398	substrate binding pocket [chemical binding]; other site
653733005399	active site
653733005400	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304
653733005401	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
653733005402	ferric uptake regulator; Provisional; Region: fur; PRK09462
653733005403	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
653733005404	metal binding site 2 [ion binding]; metal-binding site
653733005405	putative DNA binding helix; other site
653733005406	metal binding site 1 [ion binding]; metal-binding site
653733005407	dimer interface [polypeptide binding]; other site
653733005408	structural Zn2+ binding site [ion binding]; other site
653733005409	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
653733005410	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
653733005411	ABC-ATPase subunit  interface; other site
653733005412	dimer interface [polypeptide binding]; other site
653733005413	putative PBP binding regions; other site
653733005414	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
653733005415	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
653733005416	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
653733005417	Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147
653733005418	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
653733005419	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
653733005420	Glutamine amidotransferase class-I; Region: GATase; pfam00117
653733005421	glutamine binding [chemical binding]; other site
653733005422	catalytic triad [active]
653733005423	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
653733005424	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
653733005425	ATP binding site [chemical binding]; other site
653733005426	Mg2+ binding site [ion binding]; other site
653733005427	G-X-G motif; other site
653733005428	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
653733005429	2-dehydropantoate 2-reductase; Provisional; Region: PRK06249
653733005430	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
653733005431	Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079
653733005432	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
653733005433	pyridoxal 5'-phosphate binding site [chemical binding]; other site
653733005434	homodimer interface [polypeptide binding]; other site
653733005435	catalytic residue [active]
653733005436	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
653733005437	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683
653733005438	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
653733005439	MgtE intracellular N domain; Region: MgtE_N; pfam03448
653733005440	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
653733005441	Divalent cation transporter; Region: MgtE; pfam01769
653733005442	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
653733005443	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
653733005444	Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352
653733005445	Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418
653733005446	GSH binding site [chemical binding]; other site
653733005447	catalytic residues [active]
653733005448	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
653733005449	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
653733005450	dimer interface [polypeptide binding]; other site
653733005451	putative CheW interface [polypeptide binding]; other site
653733005452	Predicted Zn-dependent peptidases, insulinase-like [General function prediction only]; Region: COG1026
653733005453	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
653733005454	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
653733005455	Peptidase M16C associated; Region: M16C_assoc; pfam08367
653733005456	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
653733005457	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296
653733005458	putative active site [active]
653733005459	RimK-like ATPgrasp N-terminal domain; Region: RLAN; pfam14401
653733005460	Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) [Coenzyme metabolism / Translation, ribosomal structure and biogenesis]; Region: RimK; COG0189
653733005461	ATP-grasp domain; Region: ATP-grasp_4; cl17255
653733005462	Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954
653733005463	N-formylglutamate amidohydrolase; Region: FGase; pfam05013
653733005464	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
653733005465	HlyD family secretion protein; Region: HlyD_3; pfam13437
653733005466	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
653733005467	Protein export membrane protein; Region: SecD_SecF; cl14618
653733005468	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186
653733005469	UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331
653733005470	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
653733005471	putative catalytic site [active]
653733005472	putative phosphate binding site [ion binding]; other site
653733005473	active site
653733005474	metal binding site A [ion binding]; metal-binding site
653733005475	DNA binding site [nucleotide binding]
653733005476	putative AP binding site [nucleotide binding]; other site
653733005477	putative metal binding site B [ion binding]; other site
653733005478	SprA-related family; Region: SprA-related; pfam12118
653733005479	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
653733005480	oxidoreductase; Validated; Region: PRK05717
653733005481	NAD(P) binding site [chemical binding]; other site
653733005482	active site
653733005483	Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864
653733005484	Predicted membrane protein [Function unknown]; Region: COG3650
653733005485	META domain; Region: META; pfam03724
653733005486	Protein of unknown function (DUF3365); Region: DUF3365; pfam11845
653733005487	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
653733005488	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
653733005489	ATP binding site [chemical binding]; other site
653733005490	Mg2+ binding site [ion binding]; other site
653733005491	G-X-G motif; other site
653733005492	Transcriptional regulators [Transcription]; Region: MarR; COG1846
653733005493	MarR family; Region: MarR_2; cl17246
653733005494	membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859
653733005495	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
653733005496	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
653733005497	N-acetyl-D-glucosamine binding site [chemical binding]; other site
653733005498	catalytic residue [active]
653733005499	Response regulator receiver domain; Region: Response_reg; pfam00072
653733005500	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
653733005501	active site
653733005502	phosphorylation site [posttranslational modification]
653733005503	intermolecular recognition site; other site
653733005504	dimerization interface [polypeptide binding]; other site
653733005505	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
653733005506	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
653733005507	metal binding site [ion binding]; metal-binding site
653733005508	active site
653733005509	I-site; other site
653733005510	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
653733005511	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
653733005512	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
653733005513	putative active site [active]
653733005514	heme pocket [chemical binding]; other site
653733005515	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
653733005516	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
653733005517	putative active site [active]
653733005518	heme pocket [chemical binding]; other site
653733005519	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
653733005520	putative active site [active]
653733005521	heme pocket [chemical binding]; other site
653733005522	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
653733005523	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
653733005524	dimer interface [polypeptide binding]; other site
653733005525	phosphorylation site [posttranslational modification]
653733005526	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
653733005527	ATP binding site [chemical binding]; other site
653733005528	Mg2+ binding site [ion binding]; other site
653733005529	G-X-G motif; other site
653733005530	CheD chemotactic sensory transduction; Region: CheD; cl00810
653733005531	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
653733005532	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
653733005533	putative dimer interface [polypeptide binding]; other site
653733005534	active site pocket [active]
653733005535	putative cataytic base [active]
653733005536	Cobalt chelatase (CbiK); Region: CbiK; pfam06180
653733005537	Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784
653733005538	active site
653733005539	Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), C-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_C; cd03413
653733005540	active site
653733005541	N-terminal domain interface [polypeptide binding]; other site
653733005542	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
653733005543	active site
653733005544	SAM binding site [chemical binding]; other site
653733005545	homodimer interface [polypeptide binding]; other site
653733005546	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; Region: CobA_CobO_BtuR; pfam02572
653733005547	L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140
653733005548	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
653733005549	pyridoxal 5'-phosphate binding site [chemical binding]; other site
653733005550	homodimer interface [polypeptide binding]; other site
653733005551	catalytic residue [active]
653733005552	CobD/Cbib protein; Region: CobD_Cbib; pfam03186
653733005553	Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645
653733005554	active site
653733005555	SAM binding site [chemical binding]; other site
653733005556	homodimer interface [polypeptide binding]; other site
653733005557	cobyric acid synthase; Provisional; Region: PRK00784
653733005558	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
653733005559	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
653733005560	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
653733005561	catalytic triad [active]
653733005562	Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648
653733005563	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
653733005564	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
653733005565	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983
653733005566	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
653733005567	catalytic triad [active]
653733005568	Precorrin-8X methylmutase; Region: CbiC; pfam02570
653733005569	cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; cl00913
653733005570	Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571
653733005571	Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646
653733005572	active site
653733005573	SAM binding site [chemical binding]; other site
653733005574	homodimer interface [polypeptide binding]; other site
653733005575	Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760
653733005576	Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890
653733005577	Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641
653733005578	Diphthamide biosynthesis methyltransferase [Translation, ribosomal structure and biogenesis]; Region: DPH5; COG1798
653733005579	active site
653733005580	SAM binding site [chemical binding]; other site
653733005581	homodimer interface [polypeptide binding]; other site
653733005582	Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644
653733005583	active site
653733005584	putative homodimer interface [polypeptide binding]; other site
653733005585	SAM binding site [chemical binding]; other site
653733005586	cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075
653733005587	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
653733005588	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
653733005589	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
653733005590	dimerization interface [polypeptide binding]; other site
653733005591	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
653733005592	dimer interface [polypeptide binding]; other site
653733005593	putative CheW interface [polypeptide binding]; other site
653733005594	putative transposase OrfB; Reviewed; Region: PHA02517
653733005595	Integrase core domain; Region: rve; pfam00665
653733005596	Integrase core domain; Region: rve_3; pfam13683
653733005597	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373
653733005598	AAA domain; Region: AAA_14; pfam13173
653733005599	AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287
653733005600	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
653733005601	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
653733005602	ATP binding site [chemical binding]; other site
653733005603	putative Mg++ binding site [ion binding]; other site
653733005604	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
653733005605	nucleotide binding region [chemical binding]; other site
653733005606	ATP-binding site [chemical binding]; other site
653733005607	Uncharacterized conserved protein [Function unknown]; Region: COG1479
653733005608	Protein of unknown function DUF262; Region: DUF262; pfam03235
653733005609	Protein of unknown function (DUF1524); Region: DUF1524; pfam07510
653733005610	Protein of unknown function DUF262; Region: DUF262; pfam03235
653733005611	Uncharacterized conserved protein [Function unknown]; Region: COG1479
653733005612	Fic family protein [Function unknown]; Region: COG3177
653733005613	Fic/DOC family; Region: Fic; pfam02661
653733005614	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
653733005615	AAA domain; Region: AAA_21; pfam13304
653733005616	Walker A/P-loop; other site
653733005617	ATP binding site [chemical binding]; other site
653733005618	AAA domain; Region: AAA_21; pfam13304
653733005619	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
653733005620	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
653733005621	HsdM N-terminal domain; Region: HsdM_N; pfam12161
653733005622	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
653733005623	Methyltransferase domain; Region: Methyltransf_26; pfam13659
653733005624	KilA-N domain; Region: KilA-N; pfam04383
653733005625	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096
653733005626	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
653733005627	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
653733005628	ATP binding site [chemical binding]; other site
653733005629	putative Mg++ binding site [ion binding]; other site
653733005630	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
653733005631	non-specific DNA binding site [nucleotide binding]; other site
653733005632	salt bridge; other site
653733005633	sequence-specific DNA binding site [nucleotide binding]; other site
653733005634	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
653733005635	SmpB-tmRNA interface; other site
653733005636	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
653733005637	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
653733005638	Metal-binding active site; metal-binding site
653733005639	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
653733005640	dimer interface [polypeptide binding]; other site
653733005641	putative CheW interface [polypeptide binding]; other site
653733005642	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
653733005643	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
653733005644	dimer interface [polypeptide binding]; other site
653733005645	putative CheW interface [polypeptide binding]; other site
653733005646	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
653733005647	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
653733005648	active site
653733005649	phosphorylation site [posttranslational modification]
653733005650	intermolecular recognition site; other site
653733005651	dimerization interface [polypeptide binding]; other site
653733005652	Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862
653733005653	Response regulator receiver domain; Region: Response_reg; pfam00072
653733005654	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
653733005655	active site
653733005656	phosphorylation site [posttranslational modification]
653733005657	intermolecular recognition site; other site
653733005658	dimerization interface [polypeptide binding]; other site
653733005659	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974
653733005660	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
653733005661	substrate binding pocket [chemical binding]; other site
653733005662	membrane-bound complex binding site; other site
653733005663	PAS fold; Region: PAS_3; pfam08447
653733005664	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
653733005665	putative active site [active]
653733005666	heme pocket [chemical binding]; other site
653733005667	PAS fold; Region: PAS_3; pfam08447
653733005668	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086
653733005669	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
653733005670	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
653733005671	putative active site [active]
653733005672	heme pocket [chemical binding]; other site
653733005673	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
653733005674	dimer interface [polypeptide binding]; other site
653733005675	phosphorylation site [posttranslational modification]
653733005676	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
653733005677	ATP binding site [chemical binding]; other site
653733005678	Mg2+ binding site [ion binding]; other site
653733005679	G-X-G motif; other site
653733005680	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974
653733005681	PAS domain S-box; Region: sensory_box; TIGR00229
653733005682	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
653733005683	putative active site [active]
653733005684	heme pocket [chemical binding]; other site
653733005685	PAS fold; Region: PAS_3; pfam08447
653733005686	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
653733005687	putative active site [active]
653733005688	heme pocket [chemical binding]; other site
653733005689	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
653733005690	PAS fold; Region: PAS_3; pfam08447
653733005691	putative active site [active]
653733005692	heme pocket [chemical binding]; other site
653733005693	PAS fold; Region: PAS_3; pfam08447
653733005694	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
653733005695	heme pocket [chemical binding]; other site
653733005696	putative active site [active]
653733005697	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
653733005698	PAS domain; Region: PAS_9; pfam13426
653733005699	putative active site [active]
653733005700	heme pocket [chemical binding]; other site
653733005701	PAS domain S-box; Region: sensory_box; TIGR00229
653733005702	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
653733005703	putative active site [active]
653733005704	heme pocket [chemical binding]; other site
653733005705	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
653733005706	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
653733005707	ATP binding site [chemical binding]; other site
653733005708	Mg2+ binding site [ion binding]; other site
653733005709	G-X-G motif; other site
653733005710	Domain of unknown function (DUF3391); Region: DUF3391; pfam11871
653733005711	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
653733005712	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
653733005713	Zn2+ binding site [ion binding]; other site
653733005714	Mg2+ binding site [ion binding]; other site
653733005715	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
653733005716	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
653733005717	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
653733005718	Walker A motif; other site
653733005719	ATP binding site [chemical binding]; other site
653733005720	Walker B motif; other site
653733005721	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
653733005722	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
653733005723	nudix motif; other site
653733005724	type I citrate synthase; Reviewed; Region: PRK09569
653733005725	citrate (Si)-synthase, eukaryotic; Region: cit_synth_euk; TIGR01793
653733005726	oxalacetate binding site [chemical binding]; other site
653733005727	citrylCoA binding site [chemical binding]; other site
653733005728	coenzyme A binding site [chemical binding]; other site
653733005729	catalytic triad [active]
653733005730	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
653733005731	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
653733005732	putative dimer interface [polypeptide binding]; other site
653733005733	futalosine nucleosidase; Region: fut_nucase; TIGR03664
653733005734	Menaquinone biosynthesis; Region: VitK2_biosynth; cl17475
653733005735	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
653733005736	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
653733005737	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
653733005738	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
653733005739	S-adenosylmethionine binding site [chemical binding]; other site
653733005740	RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393
653733005741	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
653733005742	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
653733005743	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
653733005744	DNA binding residues [nucleotide binding]
653733005745	Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; cl01049
653733005746	nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055
653733005747	Ferritin-like domain; Region: Ferritin; pfam00210
653733005748	ferroxidase diiron center [ion binding]; other site
653733005749	phosphoglycolate phosphatase; Provisional; Region: PRK13222
653733005750	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
653733005751	motif II; other site
653733005752	primosome assembly protein PriA; Validated; Region: PRK05580
653733005753	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
653733005754	ATP binding site [chemical binding]; other site
653733005755	putative Mg++ binding site [ion binding]; other site
653733005756	helicase superfamily c-terminal domain; Region: HELICc; smart00490
653733005757	nucleotide binding region [chemical binding]; other site
653733005758	ATP-binding site [chemical binding]; other site
653733005759	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
653733005760	FMN binding site [chemical binding]; other site
653733005761	dimer interface [polypeptide binding]; other site
653733005762	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
653733005763	PAS domain; Region: PAS_9; pfam13426
653733005764	putative active site [active]
653733005765	heme pocket [chemical binding]; other site
653733005766	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
653733005767	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
653733005768	metal binding site [ion binding]; metal-binding site
653733005769	active site
653733005770	I-site; other site
653733005771	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
653733005772	Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033
653733005773	putative uracil binding site [chemical binding]; other site
653733005774	putative active site [active]
653733005775	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
653733005776	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
653733005777	non-specific DNA binding site [nucleotide binding]; other site
653733005778	salt bridge; other site
653733005779	sequence-specific DNA binding site [nucleotide binding]; other site
653733005780	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
653733005781	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
653733005782	ATP binding site [chemical binding]; other site
653733005783	Mg2+ binding site [ion binding]; other site
653733005784	G-X-G motif; other site
653733005785	NAD-dependent deacetylase; Provisional; Region: PRK00481
653733005786	SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2-fam; cd01407
653733005787	NAD+ binding site [chemical binding]; other site
653733005788	substrate binding site [chemical binding]; other site
653733005789	Zn binding site [ion binding]; other site
653733005790	UGMP family protein; Validated; Region: PRK09604
653733005791	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884
653733005792	Carbamoyltransferase; Region: CmcH_NodU; pfam02543
653733005793	Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate  into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354
653733005794	AMP binding site [chemical binding]; other site
653733005795	metal binding site [ion binding]; metal-binding site
653733005796	active site
653733005797	Uncharacterized homolog of PrgY (pheromone shutdown protein) [Function unknown]; Region: COG1916
653733005798	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
653733005799	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
653733005800	TPP-binding site [chemical binding]; other site
653733005801	dimer interface [polypeptide binding]; other site
653733005802	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
653733005803	PYR/PP interface [polypeptide binding]; other site
653733005804	dimer interface [polypeptide binding]; other site
653733005805	TPP binding site [chemical binding]; other site
653733005806	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
653733005807	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
653733005808	dimer interface [polypeptide binding]; other site
653733005809	catalytic triad [active]
653733005810	peroxidatic and resolving cysteines [active]
653733005811	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
653733005812	hypothetical protein; Reviewed; Region: PRK00024
653733005813	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
653733005814	MPN+ (JAMM) motif; other site
653733005815	Zinc-binding site [ion binding]; other site
653733005816	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
653733005817	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
653733005818	FeS/SAM binding site; other site
653733005819	Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918
653733005820	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
653733005821	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
653733005822	G1 box; other site
653733005823	GTP/Mg2+ binding site [chemical binding]; other site
653733005824	Switch I region; other site
653733005825	G2 box; other site
653733005826	G3 box; other site
653733005827	Switch II region; other site
653733005828	G4 box; other site
653733005829	G5 box; other site
653733005830	Nucleoside recognition; Region: Gate; pfam07670
653733005831	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
653733005832	Nucleoside recognition; Region: Gate; pfam07670
653733005833	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
653733005834	rRNA interaction site [nucleotide binding]; other site
653733005835	S8 interaction site; other site
653733005836	putative laminin-1 binding site; other site
653733005837	elongation factor Ts; Provisional; Region: tsf; PRK09377
653733005838	UBA/TS-N domain; Region: UBA; pfam00627
653733005839	Elongation factor TS; Region: EF_TS; pfam00889
653733005840	Elongation factor TS; Region: EF_TS; pfam00889
653733005841	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
653733005842	putative nucleotide binding site [chemical binding]; other site
653733005843	uridine monophosphate binding site [chemical binding]; other site
653733005844	homohexameric interface [polypeptide binding]; other site
653733005845	ribosome recycling factor; Reviewed; Region: frr; PRK00083
653733005846	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
653733005847	hinge region; other site
653733005848	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
653733005849	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
653733005850	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
653733005851	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
653733005852	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
653733005853	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
653733005854	Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750
653733005855	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
653733005856	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
653733005857	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
653733005858	putative substrate binding region [chemical binding]; other site
653733005859	Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565
653733005860	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
653733005861	active site
653733005862	phosphorylation site [posttranslational modification]
653733005863	intermolecular recognition site; other site
653733005864	dimerization interface [polypeptide binding]; other site
653733005865	Transcriptional regulator; Region: CitT; pfam12431
653733005866	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
653733005867	Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290
653733005868	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
653733005869	ATP binding site [chemical binding]; other site
653733005870	Mg2+ binding site [ion binding]; other site
653733005871	G-X-G motif; other site
653733005872	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
653733005873	IHF dimer interface [polypeptide binding]; other site
653733005874	IHF - DNA interface [nucleotide binding]; other site
653733005875	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
653733005876	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
653733005877	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
653733005878	protein binding site [polypeptide binding]; other site
653733005879	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
653733005880	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
653733005881	ADP-L-glycero-D-manno-heptose-6-epimerase; Region: heptose_epim; TIGR02197
653733005882	NAD(P) binding site [chemical binding]; other site
653733005883	active site
653733005884	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
653733005885	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
653733005886	GTP binding site; other site
653733005887	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
653733005888	N-acetyl-D-glucosamine binding site [chemical binding]; other site
653733005889	catalytic residue [active]
653733005890	Predicted permease; Region: DUF318; cl17795
653733005891	Predicted permease; Region: DUF318; cl17795
653733005892	exopolyphosphatase; Region: exo_poly_only; TIGR03706
653733005893	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
653733005894	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
653733005895	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
653733005896	trimer interface [polypeptide binding]; other site
653733005897	putative metal binding site [ion binding]; other site
653733005898	HflC protein; Region: hflC; TIGR01932
653733005899	Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405
653733005900	Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404
653733005901	HflK protein; Region: hflK; TIGR01933
653733005902	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
653733005903	putative active site [active]
653733005904	putative CoA binding site [chemical binding]; other site
653733005905	nudix motif; other site
653733005906	metal binding site [ion binding]; metal-binding site
653733005907	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
653733005908	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
653733005909	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
653733005910	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
653733005911	active site
653733005912	phosphorylation site [posttranslational modification]
653733005913	intermolecular recognition site; other site
653733005914	dimerization interface [polypeptide binding]; other site
653733005915	LytTr DNA-binding domain; Region: LytTR; smart00850
653733005916	Mechanosensitive ion channel; Region: MS_channel; pfam00924
653733005917	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
653733005918	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
653733005919	ATP binding site [chemical binding]; other site
653733005920	active site
653733005921	substrate binding site [chemical binding]; other site
653733005922	Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700
653733005923	phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619
653733005924	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
653733005925	putative active site [active]
653733005926	catalytic triad [active]
653733005927	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
653733005928	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
653733005929	dimerization interface [polypeptide binding]; other site
653733005930	ATP binding site [chemical binding]; other site
653733005931	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
653733005932	dimerization interface [polypeptide binding]; other site
653733005933	ATP binding site [chemical binding]; other site
653733005934	B12 binding domain; Region: B12-binding_2; pfam02607
653733005935	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cd02065
653733005936	B12 binding site [chemical binding]; other site
653733005937	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
653733005938	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
653733005939	dimer interface [polypeptide binding]; other site
653733005940	phosphorylation site [posttranslational modification]
653733005941	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
653733005942	ATP binding site [chemical binding]; other site
653733005943	Mg2+ binding site [ion binding]; other site
653733005944	G-X-G motif; other site
653733005945	Response regulator receiver domain; Region: Response_reg; pfam00072
653733005946	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
653733005947	active site
653733005948	phosphorylation site [posttranslational modification]
653733005949	intermolecular recognition site; other site
653733005950	dimerization interface [polypeptide binding]; other site
653733005951	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
653733005952	active site residue [active]
653733005953	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
653733005954	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
653733005955	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
653733005956	Secretin and TonB N terminus short domain; Region: STN; smart00965
653733005957	TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786
653733005958	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
653733005959	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
653733005960	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
653733005961	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
653733005962	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
653733005963	DNA binding residues [nucleotide binding]
653733005964	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
653733005965	FecR protein; Region: FecR; pfam04773
653733005966	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
653733005967	putative active site [active]
653733005968	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
653733005969	putative binding surface; other site
653733005970	active site
653733005971	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
653733005972	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
653733005973	active site
653733005974	phosphorylation site [posttranslational modification]
653733005975	intermolecular recognition site; other site
653733005976	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820
653733005977	putative hydrophobic ligand binding site [chemical binding]; other site
653733005978	superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280
653733005979	heme-binding site [chemical binding]; other site
653733005980	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
653733005981	Response regulator receiver domain; Region: Response_reg; pfam00072
653733005982	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
653733005983	active site
653733005984	phosphorylation site [posttranslational modification]
653733005985	intermolecular recognition site; other site
653733005986	dimerization interface [polypeptide binding]; other site
653733005987	Protein of unknown function (DUF3365); Region: DUF3365; pfam11845
653733005988	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
653733005989	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
653733005990	ATP binding site [chemical binding]; other site
653733005991	Mg2+ binding site [ion binding]; other site
653733005992	G-X-G motif; other site
653733005993	Protein of unknown function (DUF1504); Region: DUF1504; pfam07399
653733005994	Protein of unknown function (DUF1504); Region: DUF1504; pfam07399
653733005995	alpha-L-glutamate ligase-related protein; Region: rimK_rel_E_lig; TIGR02291
653733005996	Sugar-transfer associated ATP-grasp; Region: ATPgrasp_ST; pfam14397
653733005997	Inactive transglutaminase fused to 7 transmembrane helices; Region: Transglut_i_TM; pfam14400
653733005998	7 transmembrane helices usually fused to an inactive transglutaminase; Region: 7TM_transglut; pfam14402
653733005999	Uncharacterized protein conserved in archaea [Posttranslational modification, protein turnover, chaperones]; Region: COG4067
653733006000	polyphosphate kinase; Provisional; Region: PRK05443
653733006001	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
653733006002	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
653733006003	Catalytic C-terminal domain, first repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C1_like; cd09164
653733006004	domain interface [polypeptide binding]; other site
653733006005	active site
653733006006	catalytic site [active]
653733006007	Catalytic C-terminal domain, second repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C2_like; cd09167
653733006008	domain interface [polypeptide binding]; other site
653733006009	active site
653733006010	catalytic site [active]
653733006011	exopolyphosphatase; Region: exo_poly_only; TIGR03706
653733006012	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
653733006013	pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613
653733006014	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
653733006015	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
653733006016	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
653733006017	Protein export membrane protein; Region: SecD_SecF; cl14618
653733006018	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
653733006019	competence damage-inducible protein A; Provisional; Region: PRK00549
653733006020	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
653733006021	putative MPT binding site; other site
653733006022	Competence-damaged protein; Region: CinA; pfam02464
653733006023	Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971
653733006024	tetramer interfaces [polypeptide binding]; other site
653733006025	binuclear metal-binding site [ion binding]; other site
653733006026	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: DUF374; Region: LPLAT_DUF374-like; cd07983
653733006027	putative acyl-acceptor binding pocket; other site
653733006028	flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681
653733006029	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
653733006030	outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302
653733006031	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
653733006032	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
653733006033	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
653733006034	Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886
653733006035	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
653733006036	Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480
653733006037	7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698
653733006038	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
653733006039	Zn2+ binding site [ion binding]; other site
653733006040	Mg2+ binding site [ion binding]; other site
653733006041	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
653733006042	PhoH-like protein; Region: PhoH; pfam02562
653733006043	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
653733006044	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
653733006045	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
653733006046	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
653733006047	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
653733006048	active site
653733006049	phosphorylation site [posttranslational modification]
653733006050	intermolecular recognition site; other site
653733006051	dimerization interface [polypeptide binding]; other site
653733006052	PAS domain; Region: PAS_9; pfam13426
653733006053	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
653733006054	putative active site [active]
653733006055	heme pocket [chemical binding]; other site
653733006056	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
653733006057	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
653733006058	ATP binding site [chemical binding]; other site
653733006059	Mg2+ binding site [ion binding]; other site
653733006060	G-X-G motif; other site
653733006061	nickel responsive regulator; Provisional; Region: PRK04460
653733006062	Uncharacterized protein family (UPF0156); Region: RHH_2; cl17383
653733006063	NikR C terminal nickel binding domain; Region: NikR_C; pfam08753
653733006064	Predicted permeases [General function prediction only]; Region: COG0795
653733006065	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
653733006066	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
653733006067	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
653733006068	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
653733006069	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
653733006070	Tetramer interface [polypeptide binding]; other site
653733006071	active site
653733006072	FMN-binding site [chemical binding]; other site
653733006073	Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703
653733006074	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
653733006075	ADP binding site [chemical binding]; other site
653733006076	magnesium binding site [ion binding]; other site
653733006077	putative shikimate binding site; other site
653733006078	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
653733006079	active site
653733006080	dimer interface [polypeptide binding]; other site
653733006081	metal binding site [ion binding]; metal-binding site
653733006082	Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895
653733006083	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
653733006084	TPR motif; other site
653733006085	binding surface
653733006086	Tetratricopeptide repeat; Region: TPR_12; pfam13424
653733006087	Dehydroquinase class II; Region: DHquinase_II; pfam01220
653733006088	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
653733006089	trimer interface [polypeptide binding]; other site
653733006090	active site
653733006091	dimer interface [polypeptide binding]; other site
653733006092	menaquinone biosynthesis protein, SCO4550 family; Region: mena_SCO4550; TIGR03699
653733006093	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
653733006094	FeS/SAM binding site; other site
653733006095	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
653733006096	putative DNA modification/repair radical SAM protein; Region: rSAM_link_UDG; TIGR03916
653733006097	probable DNA metabolism protein; Region: SAM_7_link_chp; TIGR03915
653733006098	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
653733006099	Ligand Binding Site [chemical binding]; other site
653733006100	GAF domain; Region: GAF; pfam01590
653733006101	GAF domain; Region: GAF; pfam01590
653733006102	GAF domain; Region: GAF_2; pfam13185
653733006103	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
653733006104	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
653733006105	metal binding site [ion binding]; metal-binding site
653733006106	active site
653733006107	I-site; other site
653733006108	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
653733006109	Walker A/P-loop; other site
653733006110	ATP binding site [chemical binding]; other site
653733006111	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
653733006112	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
653733006113	ABC transporter signature motif; other site
653733006114	Walker B; other site
653733006115	D-loop; other site
653733006116	H-loop/switch region; other site
653733006117	3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673
653733006118	phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361
653733006119	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384
653733006120	dimer interface [polypeptide binding]; other site
653733006121	active site
653733006122	Schiff base residues; other site
653733006123	putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK14869
653733006124	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
653733006125	DRTGG domain; Region: DRTGG; pfam07085
653733006126	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
653733006127	DHHA2 domain; Region: DHHA2; pfam02833
653733006128	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
653733006129	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
653733006130	Coenzyme A binding pocket [chemical binding]; other site
653733006131	Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624
653733006132	Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659
653733006133	metal binding site [ion binding]; metal-binding site
653733006134	dimer interface [polypeptide binding]; other site
653733006135	Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249
653733006136	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
653733006137	ABC-type thiamine transport system, ATPase component [Coenzyme metabolism]; Region: ThiQ; COG3840
653733006138	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
653733006139	Walker A/P-loop; other site
653733006140	ATP binding site [chemical binding]; other site
653733006141	Q-loop/lid; other site
653733006142	ABC transporter signature motif; other site
653733006143	Walker B; other site
653733006144	D-loop; other site
653733006145	H-loop/switch region; other site
653733006146	TOBE domain; Region: TOBE; cl01440
653733006147	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
653733006148	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
653733006149	dimer interface [polypeptide binding]; other site
653733006150	conserved gate region; other site
653733006151	putative PBP binding loops; other site
653733006152	ABC-ATPase subunit interface; other site
653733006153	TOBE domain; Region: TOBE; pfam03459
653733006154	Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585
653733006155	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
653733006156	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
653733006157	N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005
653733006158	DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676
653733006159	molybdenum-pterin binding domain; Region: Mop; TIGR00638
653733006160	TOBE domain; Region: TOBE; cl01440
653733006161	GTPase RsgA; Reviewed; Region: PRK01889
653733006162	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
653733006163	GTPase/Zn-binding domain interface [polypeptide binding]; other site
653733006164	GTP/Mg2+ binding site [chemical binding]; other site
653733006165	G4 box; other site
653733006166	G5 box; other site
653733006167	G1 box; other site
653733006168	Switch I region; other site
653733006169	G2 box; other site
653733006170	G3 box; other site
653733006171	Switch II region; other site
653733006172	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581
653733006173	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
653733006174	Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924
653733006175	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
653733006176	CoA enzyme activase uncharacterized domain (DUF2229); Region: DUF2229; pfam09989
653733006177	O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873
653733006178	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
653733006179	homodimer interface [polypeptide binding]; other site
653733006180	substrate-cofactor binding pocket; other site
653733006181	pyridoxal 5'-phosphate binding site [chemical binding]; other site
653733006182	catalytic residue [active]
653733006183	Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049
653733006184	PAS domain S-box; Region: sensory_box; TIGR00229
653733006185	PAS domain; Region: PAS; smart00091
653733006186	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800
653733006187	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
653733006188	metal binding triad; other site
653733006189	Putative nucleotidyltransferase substrate binding domain; Region: DUF294_C; pfam10335
653733006190	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
653733006191	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
653733006192	active site
653733006193	metal binding site [ion binding]; metal-binding site
653733006194	GPR1/FUN34/yaaH family; Region: Grp1_Fun34_YaaH; cl00685
653733006195	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
653733006196	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK08375
653733006197	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
653733006198	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK08375
653733006199	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
653733006200	putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK07375
653733006201	Domain of unknown function (DUF4040); Region: DUF4040; cl00676
653733006202	Domain of unknown function (DUF4040); Region: DUF4040; cl00676
653733006203	putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674
653733006204	Na+/H+ ion antiporter subunit; Region: MNHE; pfam01899
653733006205	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
653733006206	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
653733006207	NAD binding site [chemical binding]; other site
653733006208	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
653733006209	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
653733006210	metal binding site [ion binding]; metal-binding site
653733006211	active site
653733006212	I-site; other site
653733006213	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
653733006214	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
653733006215	phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007
653733006216	catalytic residues [active]
653733006217	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141
653733006218	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
653733006219	putative active site [active]
653733006220	oxyanion strand; other site
653733006221	catalytic triad [active]
653733006222	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
653733006223	putative active site pocket [active]
653733006224	4-fold oligomerization interface [polypeptide binding]; other site
653733006225	metal binding residues [ion binding]; metal-binding site
653733006226	3-fold/trimer interface [polypeptide binding]; other site
653733006227	3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311
653733006228	CheD chemotactic sensory transduction; Region: CheD; cl00810
653733006229	HDOD domain; Region: HDOD; pfam08668
653733006230	HD domain; Region: HD; pfam01966
653733006231	Hemerythrin; Region: Hemerythrin; cd12107
653733006232	Fe binding site [ion binding]; other site
653733006233	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
653733006234	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
653733006235	metal binding site [ion binding]; metal-binding site
653733006236	active site
653733006237	I-site; other site
653733006238	Prolipoprotein diacylglyceryl transferase; Region: LGT; pfam01790
653733006239	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
653733006240	prolyl-tRNA synthetase; Provisional; Region: PRK09194
653733006241	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
653733006242	dimer interface [polypeptide binding]; other site
653733006243	motif 1; other site
653733006244	active site
653733006245	motif 2; other site
653733006246	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
653733006247	putative deacylase active site [active]
653733006248	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
653733006249	active site
653733006250	motif 3; other site
653733006251	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
653733006252	anticodon binding site; other site
653733006253	tetratricopeptide repeat protein; Provisional; Region: PRK11788
653733006254	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
653733006255	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
653733006256	active site
653733006257	multimer interface [polypeptide binding]; other site
653733006258	S-adenosylmethionine synthetase; Validated; Region: PRK05250
653733006259	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
653733006260	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
653733006261	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
653733006262	Hpr(Ser) kinase/phosphatase; Region: hpr-ser; TIGR00679
653733006263	HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603
653733006264	HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918
653733006265	Hpr binding site; other site
653733006266	active site
653733006267	homohexamer subunit interaction site [polypeptide binding]; other site
653733006268	glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
653733006269	AAA domain; Region: AAA_33; pfam13671
653733006270	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
653733006271	active pocket/dimerization site; other site
653733006272	active site
653733006273	phosphorylation site [posttranslational modification]
653733006274	PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830
653733006275	active site
653733006276	phosphorylation site [posttranslational modification]
653733006277	PTS system sorbose-specific iic component; Region: EII-Sor; cl01506
653733006278	PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507
653733006279	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
653733006280	dimerization domain swap beta strand [polypeptide binding]; other site
653733006281	regulatory protein interface [polypeptide binding]; other site
653733006282	active site
653733006283	regulatory phosphorylation site [posttranslational modification]; other site
653733006284	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
653733006285	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
653733006286	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
653733006287	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
653733006288	acetylornithine aminotransferase; Provisional; Region: PRK02627
653733006289	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
653733006290	inhibitor-cofactor binding pocket; inhibition site
653733006291	pyridoxal 5'-phosphate binding site [chemical binding]; other site
653733006292	catalytic residue [active]
653733006293	ornithine carbamoyltransferase; Provisional; Region: PRK00779
653733006294	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
653733006295	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
653733006296	argininosuccinate synthase; Provisional; Region: PRK13820
653733006297	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
653733006298	ANP binding site [chemical binding]; other site
653733006299	Substrate Binding Site II [chemical binding]; other site
653733006300	Substrate Binding Site I [chemical binding]; other site
653733006301	AmmeMemoRadiSam system protein A; Region: AmmeMemoSam_A; TIGR04335
653733006302	AMMECR1; Region: AMMECR1; pfam01871
653733006303	H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452
653733006304	membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733
653733006305	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
653733006306	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
653733006307	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
653733006308	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
653733006309	HflX GTPase family; Region: HflX; cd01878
653733006310	G1 box; other site
653733006311	GTP/Mg2+ binding site [chemical binding]; other site
653733006312	Switch I region; other site
653733006313	G2 box; other site
653733006314	G3 box; other site
653733006315	Switch II region; other site
653733006316	G4 box; other site
653733006317	G5 box; other site
653733006318	Uncharacterized conserved protein [Function unknown]; Region: COG1434
653733006319	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
653733006320	putative active site [active]
653733006321	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
653733006322	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
653733006323	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
653733006324	Walker A/P-loop; other site
653733006325	ATP binding site [chemical binding]; other site
653733006326	Q-loop/lid; other site
653733006327	ABC transporter signature motif; other site
653733006328	Walker B; other site
653733006329	D-loop; other site
653733006330	H-loop/switch region; other site
653733006331	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
653733006332	ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864
653733006333	Walker A/P-loop; other site
653733006334	ATP binding site [chemical binding]; other site
653733006335	Q-loop/lid; other site
653733006336	ABC transporter signature motif; other site
653733006337	Walker B; other site
653733006338	D-loop; other site
653733006339	H-loop/switch region; other site
653733006340	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
653733006341	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
653733006342	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
653733006343	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
653733006344	Walker A/P-loop; other site
653733006345	ATP binding site [chemical binding]; other site
653733006346	Q-loop/lid; other site
653733006347	ABC transporter signature motif; other site
653733006348	Walker B; other site
653733006349	D-loop; other site
653733006350	H-loop/switch region; other site
653733006351	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
653733006352	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
653733006353	N-terminal plug; other site
653733006354	ligand-binding site [chemical binding]; other site
653733006355	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
653733006356	ABC-type Co2+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CbiK; COG5266
653733006357	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
653733006358	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
653733006359	N-terminal plug; other site
653733006360	ligand-binding site [chemical binding]; other site
653733006361	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
653733006362	macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535
653733006363	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
653733006364	Walker A/P-loop; other site
653733006365	ATP binding site [chemical binding]; other site
653733006366	Q-loop/lid; other site
653733006367	ABC transporter signature motif; other site
653733006368	Walker B; other site
653733006369	D-loop; other site
653733006370	H-loop/switch region; other site
653733006371	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
653733006372	FtsX-like permease family; Region: FtsX; pfam02687
653733006373	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
653733006374	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
653733006375	HlyD family secretion protein; Region: HlyD_3; pfam13437
653733006376	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
653733006377	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
653733006378	Flavodoxin; Region: Flavodoxin_1; pfam00258
653733006379	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499
653733006380	Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771
653733006381	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
653733006382	N-terminal plug; other site
653733006383	ligand-binding site [chemical binding]; other site
653733006384	GxxExxY protein; Region: GxxExxY; TIGR04256
653733006385	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
653733006386	TPR motif; other site
653733006387	binding surface
653733006388	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
653733006389	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
653733006390	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
653733006391	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
653733006392	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
653733006393	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; pfam01618
653733006394	Protein of unknown function (DUF3450); Region: DUF3450; pfam11932
653733006395	Mu-like prophage protein Com; Region: Mu-like_Com; cl11540
653733006396	DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609
653733006397	umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700
653733006398	active site
653733006399	DNA binding site [nucleotide binding]
653733006400	Domain of unknown function (DUF4113); Region: DUF4113; pfam13438
653733006401	SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974
653733006402	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
653733006403	Catalytic site [active]
653733006404	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
653733006405	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
653733006406	putative dimer interface [polypeptide binding]; other site
653733006407	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
653733006408	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
653733006409	putative dimer interface [polypeptide binding]; other site
653733006410	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, alpha subunit [Energy production and conversion]; Region: PorA; COG0674
653733006411	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
653733006412	dimer interface [polypeptide binding]; other site
653733006413	PYR/PP interface [polypeptide binding]; other site
653733006414	TPP binding site [chemical binding]; other site
653733006415	substrate binding site [chemical binding]; other site
653733006416	pyruvate ferredoxin oxidoreductase subunit beta; Provisional; Region: PRK11865
653733006417	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
653733006418	TPP-binding site [chemical binding]; other site
653733006419	pyruvate/ketoisovalerate ferredoxin oxidoreductase subunit gamma; Provisional; Region: PRK14029
653733006420	Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546
653733006421	4Fe-4S dicluster domain; Region: Fer4_10; pfam13237
653733006422	recombination protein RecR; Reviewed; Region: recR; PRK00076
653733006423	RecR protein; Region: RecR; pfam02132
653733006424	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
653733006425	active site
653733006426	metal binding site [ion binding]; metal-binding site
653733006427	hypothetical protein; Validated; Region: PRK00153
653733006428	DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397
653733006429	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
653733006430	Walker A motif; other site
653733006431	ATP binding site [chemical binding]; other site
653733006432	Walker B motif; other site
653733006433	arginine finger; other site
653733006434	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
653733006435	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
653733006436	Formyltetrahydrofolate hydrolase [Nucleotide transport and metabolism]; Region: PurU; COG0788
653733006437	Formyltransferase, catalytic core domain; Region: FMT_core; cl00395
653733006438	active site
653733006439	substrate binding site [chemical binding]; other site
653733006440	cosubstrate binding site; other site
653733006441	catalytic site [active]
653733006442	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
653733006443	DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086
653733006444	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
653733006445	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
653733006446	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
653733006447	RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998
653733006448	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
653733006449	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
653733006450	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
653733006451	DNA binding site [nucleotide binding]
653733006452	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
653733006453	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
653733006454	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
653733006455	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
653733006456	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
653733006457	RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562
653733006458	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
653733006459	RPB3 interaction site [polypeptide binding]; other site
653733006460	RPB1 interaction site [polypeptide binding]; other site
653733006461	RPB11 interaction site [polypeptide binding]; other site
653733006462	RPB10 interaction site [polypeptide binding]; other site
653733006463	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
653733006464	L11 interface [polypeptide binding]; other site
653733006465	putative EF-Tu interaction site [polypeptide binding]; other site
653733006466	putative EF-G interaction site [polypeptide binding]; other site
653733006467	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
653733006468	23S rRNA interface [nucleotide binding]; other site
653733006469	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
653733006470	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
653733006471	mRNA/rRNA interface [nucleotide binding]; other site
653733006472	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
653733006473	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
653733006474	23S rRNA interface [nucleotide binding]; other site
653733006475	L7/L12 interface [polypeptide binding]; other site
653733006476	putative thiostrepton binding site; other site
653733006477	L25 interface [polypeptide binding]; other site
653733006478	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
653733006479	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
653733006480	putative homodimer interface [polypeptide binding]; other site
653733006481	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
653733006482	heterodimer interface [polypeptide binding]; other site
653733006483	homodimer interface [polypeptide binding]; other site
653733006484	SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584
653733006485	50S ribosomal protein L33; Validated; Region: rpmG; PRK00504
653733006486	elongation factor Tu; Reviewed; Region: PRK00049
653733006487	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
653733006488	G1 box; other site
653733006489	GEF interaction site [polypeptide binding]; other site
653733006490	GTP/Mg2+ binding site [chemical binding]; other site
653733006491	Switch I region; other site
653733006492	G2 box; other site
653733006493	G3 box; other site
653733006494	Switch II region; other site
653733006495	G4 box; other site
653733006496	G5 box; other site
653733006497	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
653733006498	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
653733006499	Antibiotic Binding Site [chemical binding]; other site
653733006500	3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; pfam01977
653733006501	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08665
653733006502	Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317
653733006503	Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888
653733006504	active site
653733006505	dimer interface [polypeptide binding]; other site
653733006506	effector binding site; other site
653733006507	TSCPD domain; Region: TSCPD; cl14834
653733006508	Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242
653733006509	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
653733006510	FeS/SAM binding site; other site
653733006511	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
653733006512	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
653733006513	substrate binding site [chemical binding]; other site
653733006514	glutamase interaction surface [polypeptide binding]; other site
653733006515	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
653733006516	Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291
653733006517	pyridoxal 5'-phosphate binding site [chemical binding]; other site
653733006518	catalytic residue [active]
653733006519	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
653733006520	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
653733006521	active site
653733006522	phosphorylation site [posttranslational modification]
653733006523	intermolecular recognition site; other site
653733006524	dimerization interface [polypeptide binding]; other site
653733006525	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
653733006526	Walker A motif; other site
653733006527	ATP binding site [chemical binding]; other site
653733006528	Walker B motif; other site
653733006529	arginine finger; other site
653733006530	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
653733006531	Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000
653733006532	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
653733006533	dimerization interface [polypeptide binding]; other site
653733006534	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
653733006535	putative active site [active]
653733006536	heme pocket [chemical binding]; other site
653733006537	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
653733006538	dimer interface [polypeptide binding]; other site
653733006539	phosphorylation site [posttranslational modification]
653733006540	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
653733006541	ATP binding site [chemical binding]; other site
653733006542	Mg2+ binding site [ion binding]; other site
653733006543	G-X-G motif; other site
653733006544	Domain of unknown function (DUF4390); Region: DUF4390; pfam14334
653733006545	Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602
653733006546	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
653733006547	FeS/SAM binding site; other site
653733006548	Domain of unknown function (DUF366); Region: DUF366; cl00890
653733006549	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
653733006550	RNA/DNA hybrid binding site [nucleotide binding]; other site
653733006551	active site
653733006552	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
653733006553	Flagellar hook-associated protein [Cell motility and secretion]; Region: FlgK; COG1256
653733006554	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
653733006555	FlgN protein; Region: FlgN; pfam05130
653733006556	flagellar biosynthesis anti-sigma factor FlgM; Region: FlgM_jcvi; TIGR03824
653733006557	Rod binding protein; Region: Rod-binding; pfam10135
653733006558	Uncharacterized conserved protein [Function unknown]; Region: COG1543
653733006559	N-terminal catalytic domain of  alpha-amylase ( AmyC ) and similar proteins; Region: GH57N_AmyC_like; cd10792
653733006560	active site
653733006561	substrate binding site [chemical binding]; other site
653733006562	catalytic site [active]
653733006563	Domain of unknown function (DUF1957); Region: DUF1957; pfam09210
653733006564	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3330
653733006565	ADP-glucose phosphorylase; Region: PLN02643
653733006566	HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228
653733006567	nucleotide binding site/active site [active]
653733006568	HIT family signature motif; other site
653733006569	catalytic residue [active]
653733006570	N-terminal catalytic domain of 4-alpha-glucanotransferase; glycoside hydrolase family 57 (GH57); Region: GH57N_TLGT_like; cd10793
653733006571	Glycosyl hydrolase family 57; Region: Glyco_hydro_57; pfam03065
653733006572	active site
653733006573	catalytic site [active]
653733006574	homodimer interface [polypeptide binding]; other site
653733006575	Lid 1; other site
653733006576	Domain of unknown function (DUF1925); Region: DUF1925; pfam09094
653733006577	Domain of unknown function (DUF1926); Region: DUF1926; pfam09095
653733006578	Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293
653733006579	Domain of unknown function (DUF814); Region: DUF814; pfam05670
653733006580	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
653733006581	histidinol dehydrogenase; Region: hisD; TIGR00069
653733006582	NAD binding site [chemical binding]; other site
653733006583	dimerization interface [polypeptide binding]; other site
653733006584	product binding site; other site
653733006585	substrate binding site [chemical binding]; other site
653733006586	zinc binding site [ion binding]; other site
653733006587	catalytic residues [active]
653733006588	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
653733006589	catalytic core [active]
653733006590	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
653733006591	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
653733006592	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
653733006593	S-adenosylmethionine binding site [chemical binding]; other site
653733006594	Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes SLAC1 (Slow Anion Channel-Associated 1); Region: TDT_SLAC1_like; cd09323
653733006595	gating phenylalanine in ion channel; other site
653733006596	Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288
653733006597	putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823
653733006598	NADP binding site [chemical binding]; other site
653733006599	dimer interface [polypeptide binding]; other site
653733006600	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
653733006601	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
653733006602	bidirectional hydrogenase complex protein HoxE; Reviewed; Region: PRK07571
653733006603	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
653733006604	putative dimer interface [polypeptide binding]; other site
653733006605	[2Fe-2S] cluster binding site [ion binding]; other site
653733006606	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
653733006607	dimer interface [polypeptide binding]; other site
653733006608	[2Fe-2S] cluster binding site [ion binding]; other site
653733006609	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
653733006610	SLBB domain; Region: SLBB; pfam10531
653733006611	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589
653733006612	bidirectional hydrogenase complex protein HoxU; Validated; Region: PRK07569
653733006613	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
653733006614	catalytic loop [active]
653733006615	iron binding site [ion binding]; other site
653733006616	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
653733006617	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058
653733006618	Uncharacterized conserved protein [Function unknown]; Region: COG3791
653733006619	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
653733006620	Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093
653733006621	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
653733006622	non-specific DNA binding site [nucleotide binding]; other site
653733006623	salt bridge; other site
653733006624	sequence-specific DNA binding site [nucleotide binding]; other site
653733006625	putative transposase OrfB; Reviewed; Region: PHA02517
653733006626	HTH-like domain; Region: HTH_21; pfam13276
653733006627	Integrase core domain; Region: rve; pfam00665
653733006628	Integrase core domain; Region: rve_3; pfam13683
653733006629	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
653733006630	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
653733006631	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
653733006632	Methyltransferase domain; Region: Methyltransf_31; pfam13847
653733006633	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
653733006634	S-adenosylmethionine binding site [chemical binding]; other site
653733006635	Lipocalin-like domain; Region: Lipocalin_2; pfam08212
653733006636	Nitrate and nitrite sensing; Region: NIT; pfam08376
653733006637	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
653733006638	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
653733006639	metal binding site [ion binding]; metal-binding site
653733006640	active site
653733006641	I-site; other site
653733006642	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
653733006643	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
653733006644	ligand binding site [chemical binding]; other site
653733006645	flexible hinge region; other site
653733006646	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
653733006647	Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967
653733006648	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
653733006649	NAD(P) binding site [chemical binding]; other site
653733006650	active site
653733006651	Methyltransferase domain; Region: Methyltransf_31; pfam13847
653733006652	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
653733006653	S-adenosylmethionine binding site [chemical binding]; other site
653733006654	Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259
653733006655	Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374
653733006656	Hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). These enzymes belong to the peptidase family M52. Maturation of [FeNi] hydrogenases includes formation of the nickel metallocenter, proteolytic processing...; Region: H2MP; cl00477
653733006657	nickel binding site [ion binding]; other site
653733006658	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
653733006659	MgtE intracellular N domain; Region: MgtE_N; pfam03448
653733006660	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
653733006661	Divalent cation transporter; Region: MgtE; pfam01769
653733006662	CO dehydrogenase maturation factor [Cell division and chromosome partitioning]; Region: CooC; COG3640
653733006663	The accessory protein CooC, which contains a nucleotide-binding domain (P-loop) near the N-terminus, participates in the maturation of the nickel center of carbon monoxide dehydrogenase (CODH). CODH from Rhodospirillum rubrum catalyzes the reversible...; Region: CooC; cd02034
653733006664	P-loop; other site
653733006665	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
653733006666	carbon-monoxide dehydrogenase, catalytic subunit; Region: CO_DH_cata; TIGR01702
653733006667	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
653733006668	ACS interaction site; other site
653733006669	CODH interaction site; other site
653733006670	metal cluster binding site [ion binding]; other site
653733006671	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
653733006672	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
653733006673	flexible hinge region; other site
653733006674	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
653733006675	putative switch regulator; other site
653733006676	non-specific DNA interactions [nucleotide binding]; other site
653733006677	DNA binding site [nucleotide binding]
653733006678	sequence specific DNA binding site [nucleotide binding]; other site
653733006679	putative cAMP binding site [chemical binding]; other site
653733006680	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
653733006681	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
653733006682	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
653733006683	5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222
653733006684	CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312
653733006685	THF binding site; other site
653733006686	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
653733006687	substrate binding site [chemical binding]; other site
653733006688	THF binding site; other site
653733006689	zinc-binding site [ion binding]; other site
653733006690	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
653733006691	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
653733006692	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
653733006693	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
653733006694	Flavodoxin domain; Region: Flavodoxin_3; pfam12641
653733006695	putative heme utilization carrier protein HutX; Region: HutX; TIGR04108
653733006696	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
653733006697	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
653733006698	Walker A/P-loop; other site
653733006699	ATP binding site [chemical binding]; other site
653733006700	Q-loop/lid; other site
653733006701	ABC transporter signature motif; other site
653733006702	Walker B; other site
653733006703	D-loop; other site
653733006704	H-loop/switch region; other site
653733006705	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
653733006706	cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166
653733006707	Walker A/P-loop; other site
653733006708	ATP binding site [chemical binding]; other site
653733006709	Q-loop/lid; other site
653733006710	ABC transporter signature motif; other site
653733006711	Walker B; other site
653733006712	D-loop; other site
653733006713	H-loop/switch region; other site
653733006714	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
653733006715	Hypothetical bacterial integral membrane protein (Trep_Strep); Region: Trep_Strep; cl09823
653733006716	TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785
653733006717	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
653733006718	N-terminal plug; other site
653733006719	ligand-binding site [chemical binding]; other site
653733006720	putative heme utilization radical SAM enzyme HutW; Region: rSAM_HutW; TIGR04107
653733006721	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
653733006722	FeS/SAM binding site; other site
653733006723	Mu-like prophage protein Com; Region: Mu-like_Com; cl11540
653733006724	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
653733006725	ATP binding site [chemical binding]; other site
653733006726	Mg2+ binding site [ion binding]; other site
653733006727	G-X-G motif; other site
653733006728	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
653733006729	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
653733006730	Soluble P-type ATPase [General function prediction only]; Region: COG4087
653733006731	FeoA domain; Region: FeoA; pfam04023
653733006732	Ferrous iron transport protein B; Region: FeoB_N; pfam02421
653733006733	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
653733006734	G1 box; other site
653733006735	GTP/Mg2+ binding site [chemical binding]; other site
653733006736	Switch I region; other site
653733006737	G2 box; other site
653733006738	G3 box; other site
653733006739	Switch II region; other site
653733006740	G4 box; other site
653733006741	G5 box; other site
653733006742	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
653733006743	Nucleoside recognition; Region: Gate; pfam07670
653733006744	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
653733006745	Nucleoside recognition; Region: Gate; pfam07670
653733006746	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
653733006747	S-adenosylmethionine binding site [chemical binding]; other site
653733006748	Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219
653733006749	Domain of unknown function (DUF4198); Region: DUF4198; pfam10670
653733006750	aromatic acid decarboxylase; Validated; Region: PRK05920
653733006751	Flavoprotein; Region: Flavoprotein; pfam02441
653733006752	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
653733006753	CoenzymeA binding site [chemical binding]; other site
653733006754	subunit interaction site [polypeptide binding]; other site
653733006755	PHB binding site; other site
653733006756	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
653733006757	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
653733006758	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
653733006759	Peptidase family M23; Region: Peptidase_M23; pfam01551
653733006760	Cell division protein FtsL; Region: FtsL; cl11433
653733006761	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
653733006762	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
653733006763	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
653733006764	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
653733006765	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
653733006766	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
653733006767	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
653733006768	S4 domain; Region: S4_2; pfam13275
653733006769	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
653733006770	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
653733006771	catalytic motif [active]
653733006772	Zn binding site [ion binding]; other site
653733006773	RibD C-terminal domain; Region: RibD_C; cl17279
653733006774	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
653733006775	ABC1 family; Region: ABC1; cl17513
653733006776	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
653733006777	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988
653733006778	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
653733006779	catalytic site [active]
653733006780	subunit interface [polypeptide binding]; other site
653733006781	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
653733006782	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
653733006783	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
653733006784	ATP binding site [chemical binding]; other site
653733006785	Mg2+ binding site [ion binding]; other site
653733006786	G-X-G motif; other site
653733006787	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
653733006788	ATP binding site [chemical binding]; other site
653733006789	MutL C terminal dimerisation domain; Region: MutL_C; smart00853
653733006790	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
653733006791	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
653733006792	SapC; Region: SapC; pfam07277
653733006793	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
653733006794	TPR motif; other site
653733006795	binding surface
653733006796	Tetratricopeptide repeat; Region: TPR_16; pfam13432
653733006797	Protein of unknown function (DUF560); Region: DUF560; pfam04575
653733006798	FecR protein; Region: FecR; pfam04773
653733006799	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
653733006800	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
653733006801	Leucine-rich repeats; other site
653733006802	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
653733006803	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
653733006804	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
653733006805	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
653733006806	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
653733006807	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
653733006808	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
653733006809	fumarate hydratase; Provisional; Region: PRK15389
653733006810	Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681
653733006811	Fumarase C-terminus; Region: Fumerase_C; pfam05683
653733006812	C factor cell-cell signaling protein; Provisional; Region: PRK09009
653733006813	carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325
653733006814	NADP binding site [chemical binding]; other site
653733006815	homodimer interface [polypeptide binding]; other site
653733006816	active site
653733006817	diaminopimelate dehydrogenase; Region: DAP-DH; TIGR01921
653733006818	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
653733006819	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
653733006820	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_10; cd07251
653733006821	Methyltransferase domain; Region: Methyltransf_31; pfam13847
653733006822	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
653733006823	S-adenosylmethionine binding site [chemical binding]; other site
653733006824	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
653733006825	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
653733006826	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
653733006827	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
653733006828	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
653733006829	ATP binding site [chemical binding]; other site
653733006830	Mg2+ binding site [ion binding]; other site
653733006831	G-X-G motif; other site
653733006832	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
653733006833	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
653733006834	pyridoxal 5'-phosphate binding site [chemical binding]; other site
653733006835	catalytic residue [active]
653733006836	octaheme c-type cytochrome, tetrathionate reductase family; Region: octaheme_Shew; TIGR04315
653733006837	Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cl03439
653733006838	heme-binding residues [chemical binding]; other site
653733006839	Cytochrome c bacterial; Region: Cytochrome_cB; pfam11783
653733006840	Nif-specific regulatory protein; Region: nifA; TIGR01817
653733006841	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
653733006842	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
653733006843	Walker A motif; other site
653733006844	ATP binding site [chemical binding]; other site
653733006845	Walker B motif; other site
653733006846	arginine finger; other site
653733006847	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
653733006848	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
653733006849	Radical SAM superfamily; Region: Radical_SAM; pfam04055
653733006850	FeS/SAM binding site; other site
653733006851	trans-homoaconitate synthase; Reviewed; Region: aksA; PRK11858
653733006852	Streptomyces rubellomurinus FrbC and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_NifV; cd07939
653733006853	active site
653733006854	catalytic residues [active]
653733006855	metal binding site [ion binding]; metal-binding site
653733006856	Predicted inhibitor of MCP methylation, homolog of CheC [Cell motility and secretion]; Region: COG1406
653733006857	Chemotaxis phosphatase CheX; Region: CheX; pfam13690
653733006858	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
653733006859	putative deacylase active site [active]
653733006860	Haemolytic domain; Region: Haemolytic; cl00506
653733006861	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
653733006862	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
653733006863	substrate binding pocket [chemical binding]; other site
653733006864	membrane-bound complex binding site; other site
653733006865	hinge residues; other site
653733006866	PAS fold; Region: PAS_4; pfam08448
653733006867	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
653733006868	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
653733006869	ATP binding site [chemical binding]; other site
653733006870	Mg2+ binding site [ion binding]; other site
653733006871	G-X-G motif; other site
653733006872	YCII-related domain; Region: YCII; cl00999
653733006873	Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359
653733006874	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
653733006875	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
653733006876	putative RNA binding site [nucleotide binding]; other site
653733006877	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
653733006878	S-adenosylmethionine binding site [chemical binding]; other site
653733006879	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
653733006880	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
653733006881	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
653733006882	active site
653733006883	dimerization interface [polypeptide binding]; other site
653733006884	Predicted membrane protein [Function unknown]; Region: COG3431
653733006885	Smr domain; Region: Smr; pfam01713
653733006886	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
653733006887	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
653733006888	Walker A/P-loop; other site
653733006889	ATP binding site [chemical binding]; other site
653733006890	Q-loop/lid; other site
653733006891	ABC transporter signature motif; other site
653733006892	Walker B; other site
653733006893	D-loop; other site
653733006894	H-loop/switch region; other site
653733006895	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
653733006896	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
653733006897	dimer interface [polypeptide binding]; other site
653733006898	conserved gate region; other site
653733006899	ABC-ATPase subunit interface; other site
653733006900	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
653733006901	dimer interface [polypeptide binding]; other site
653733006902	conserved gate region; other site
653733006903	putative PBP binding loops; other site
653733006904	ABC-ATPase subunit interface; other site
653733006905	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
653733006906	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
653733006907	Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049
653733006908	HAMP domain; Region: HAMP; pfam00672
653733006909	dimerization interface [polypeptide binding]; other site
653733006910	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
653733006911	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
653733006912	dimer interface [polypeptide binding]; other site
653733006913	putative CheW interface [polypeptide binding]; other site
653733006914	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
653733006915	Response regulator receiver domain; Region: Response_reg; pfam00072
653733006916	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
653733006917	active site
653733006918	phosphorylation site [posttranslational modification]
653733006919	intermolecular recognition site; other site
653733006920	dimerization interface [polypeptide binding]; other site
653733006921	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
653733006922	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
653733006923	23S rRNA interface [nucleotide binding]; other site
653733006924	L3 interface [polypeptide binding]; other site
653733006925	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
653733006926	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197
653733006927	active site
653733006928	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
653733006929	PAS domain; Region: PAS_9; pfam13426
653733006930	putative active site [active]
653733006931	heme pocket [chemical binding]; other site
653733006932	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
653733006933	PAS domain; Region: PAS_9; pfam13426
653733006934	putative active site [active]
653733006935	heme pocket [chemical binding]; other site
653733006936	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
653733006937	dimer interface [polypeptide binding]; other site
653733006938	phosphorylation site [posttranslational modification]
653733006939	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
653733006940	ATP binding site [chemical binding]; other site
653733006941	Mg2+ binding site [ion binding]; other site
653733006942	G-X-G motif; other site
653733006943	Response regulator receiver domain; Region: Response_reg; pfam00072
653733006944	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
653733006945	active site
653733006946	phosphorylation site [posttranslational modification]
653733006947	intermolecular recognition site; other site
653733006948	dimerization interface [polypeptide binding]; other site
653733006949	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
653733006950	Response regulator receiver domain; Region: Response_reg; pfam00072
653733006951	active site
653733006952	phosphorylation site [posttranslational modification]
653733006953	intermolecular recognition site; other site
653733006954	dimerization interface [polypeptide binding]; other site
653733006955	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086
653733006956	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
653733006957	binding surface
653733006958	TPR motif; other site
653733006959	Tetratricopeptide repeat; Region: TPR_16; pfam13432
653733006960	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
653733006961	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
653733006962	Walker A/P-loop; other site
653733006963	ATP binding site [chemical binding]; other site
653733006964	Q-loop/lid; other site
653733006965	ABC transporter signature motif; other site
653733006966	Walker B; other site
653733006967	D-loop; other site
653733006968	H-loop/switch region; other site
653733006969	ABC transporter; Region: ABC_tran_2; pfam12848
653733006970	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
653733006971	cobalamin synthase; Reviewed; Region: cobS; PRK00235
653733006972	Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542
653733006973	Transposase; Region: DDE_Tnp_ISL3; pfam01610
653733006974	Cobinamide kinase / cobinamide phosphate guanyltransferase; Region: CobU; pfam02283
653733006975	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
653733006976	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
653733006977	tartrate dehydrogenase; Region: TTC; TIGR02089
653733006978	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
653733006979	Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525
653733006980	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
653733006981	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
653733006982	Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030
653733006983	Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_1; cd07020
653733006984	dimer interface [polypeptide binding]; other site
653733006985	active site residues [active]
653733006986	Protein of unknown function (DUF996); Region: DUF996; pfam06195
653733006987	NfeD-like C-terminal, partner-binding; Region: NfeD; pfam01957
653733006988	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
653733006989	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
653733006990	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
653733006991	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
653733006992	binding surface
653733006993	TPR motif; other site
653733006994	TPR repeat; Region: TPR_11; pfam13414
653733006995	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
653733006996	binding surface
653733006997	TPR motif; other site
653733006998	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
653733006999	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
653733007000	binding surface
653733007001	TPR motif; other site
653733007002	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
653733007003	binding surface
653733007004	TPR motif; other site
653733007005	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
653733007006	binding surface
653733007007	TPR motif; other site
653733007008	Methyltransferase domain; Region: Methyltransf_11; pfam08241
653733007009	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
653733007010	putative active site pocket [active]
653733007011	dimerization interface [polypeptide binding]; other site
653733007012	putative catalytic residue [active]
653733007013	Protein of unknown function (DUF3365); Region: DUF3365; pfam11845
653733007014	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
653733007015	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
653733007016	dimer interface [polypeptide binding]; other site
653733007017	putative CheW interface [polypeptide binding]; other site
653733007018	NYN ribonuclease and ATPase of PhoH family domains [General    function prediction only]; Region: COG1875
653733007019	PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883
653733007020	putative active site [active]
653733007021	PhoH-like protein; Region: PhoH; pfam02562
653733007022	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
653733007023	radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960
653733007024	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
653733007025	FeS/SAM binding site; other site
653733007026	radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936
653733007027	Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; pfam10105
653733007028	enolase; Provisional; Region: eno; PRK00077
653733007029	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
653733007030	dimer interface [polypeptide binding]; other site
653733007031	metal binding site [ion binding]; metal-binding site
653733007032	substrate binding pocket [chemical binding]; other site
653733007033	BAX inhibitor (BI)-1/YccA-like protein family; Region: BI-1-like; cl00473
653733007034	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
653733007035	Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079
653733007036	ScpA/B protein; Region: ScpA_ScpB; cl00598
653733007037	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
653733007038	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
653733007039	active site
653733007040	HIGH motif; other site
653733007041	dimer interface [polypeptide binding]; other site
653733007042	KMSKS motif; other site
653733007043	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
653733007044	D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301
653733007045	dimerization interface [polypeptide binding]; other site
653733007046	ligand binding site [chemical binding]; other site
653733007047	NADP binding site [chemical binding]; other site
653733007048	catalytic site [active]
653733007049	amidophosphoribosyltransferase; Provisional; Region: PRK09123
653733007050	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
653733007051	active site
653733007052	tetramer interface [polypeptide binding]; other site
653733007053	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
653733007054	active site
653733007055	Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382
653733007056	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
653733007057	putative active site [active]
653733007058	metal binding site [ion binding]; metal-binding site
653733007059	homodimer binding site [polypeptide binding]; other site
653733007060	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
653733007061	RNA/DNA hybrid binding site [nucleotide binding]; other site
653733007062	active site
653733007063	2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867
653733007064	Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375
653733007065	TPP-binding site [chemical binding]; other site
653733007066	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
653733007067	2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710
653733007068	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
653733007069	dimer interface [polypeptide binding]; other site
653733007070	PYR/PP interface [polypeptide binding]; other site
653733007071	TPP binding site [chemical binding]; other site
653733007072	substrate binding site [chemical binding]; other site
653733007073	succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570
653733007074	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
653733007075	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
653733007076	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573
653733007077	L-aspartate oxidase; Provisional; Region: PRK06175
653733007078	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
653733007079	succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046
653733007080	Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498
653733007081	putative Iron-sulfur protein interface [polypeptide binding]; other site
653733007082	proximal heme binding site [chemical binding]; other site
653733007083	distal heme binding site [chemical binding]; other site
653733007084	putative dimer interface [polypeptide binding]; other site
653733007085	malate dehydrogenase; Reviewed; Region: PRK06223
653733007086	L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339
653733007087	NAD(P) binding site [chemical binding]; other site
653733007088	dimer interface [polypeptide binding]; other site
653733007089	tetramer (dimer of dimers) interface [polypeptide binding]; other site
653733007090	substrate binding site [chemical binding]; other site
653733007091	Monomeric isocitrate dehydrogenase; Region: IDH; cl15383
653733007092	Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838
653733007093	coproporphyrinogen III oxidase; Validated; Region: PRK05628
653733007094	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
653733007095	FeS/SAM binding site; other site
653733007096	HemN C-terminal domain; Region: HemN_C; pfam06969
653733007097	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
653733007098	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
653733007099	binding surface
653733007100	TPR motif; other site
653733007101	Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053
653733007102	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
653733007103	homodimer interface [polypeptide binding]; other site
653733007104	substrate-cofactor binding pocket; other site
653733007105	pyridoxal 5'-phosphate binding site [chemical binding]; other site
653733007106	catalytic residue [active]
653733007107	Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053
653733007108	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
653733007109	homodimer interface [polypeptide binding]; other site
653733007110	substrate-cofactor binding pocket; other site
653733007111	pyridoxal 5'-phosphate binding site [chemical binding]; other site
653733007112	catalytic residue [active]
653733007113	Protein of unknown function (DUF1007); Region: DUF1007; cl01487
653733007114	High-affinity nickel-transport protein; Region: NicO; cl00964
653733007115	Heme-copper oxidase subunit I.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane.  The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275
653733007116	Low-spin heme binding site [chemical binding]; other site
653733007117	Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115
653733007118	D-pathway; other site
653733007119	Putative water exit pathway; other site
653733007120	Binuclear center (active site) [active]
653733007121	K-pathway; other site
653733007122	Putative proton exit pathway; other site
653733007123	putative bifunctional cbb3-type cytochrome c oxidase subunit II/cytochrome c; Provisional; Region: PRK14486
653733007124	cbb3-type cytochrome c oxidase subunit II; Provisional; Region: PRK14487
653733007125	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
653733007126	Cbb3-type cytochrome oxidase component FixQ; Region: FixQ; pfam05545
653733007127	cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782
653733007128	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
653733007129	cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745
653733007130	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
653733007131	Ubp3 associated protein Bre5; Region: Bre5; pfam11614
653733007132	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
653733007133	Transposase; Region: HTH_Tnp_1; pfam01527
653733007134	putative transposase OrfB; Reviewed; Region: PHA02517
653733007135	HTH-like domain; Region: HTH_21; pfam13276
653733007136	Integrase core domain; Region: rve; pfam00665
653733007137	Integrase core domain; Region: rve_3; pfam13683
653733007138	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
653733007139	Interdomain contacts; other site
653733007140	Cytokine receptor motif; other site
653733007141	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
653733007142	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
653733007143	Leucine-rich repeats; other site
653733007144	Substrate binding site [chemical binding]; other site
653733007145	Leucine rich repeat; Region: LRR_8; pfam13855
653733007146	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
653733007147	Leucine rich repeat; Region: LRR_8; pfam13855
653733007148	FixH; Region: FixH; pfam05751
653733007149	Putative metal-binding domain of cation transport ATPase; Region: ATPase-cat_bd; pfam12156
653733007150	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
653733007151	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
653733007152	metal-binding site [ion binding]
653733007153	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
653733007154	Soluble P-type ATPase [General function prediction only]; Region: COG4087
653733007155	Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; pfam03597
653733007156	pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519
653733007157	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
653733007158	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
653733007159	binding surface
653733007160	TPR motif; other site
653733007161	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
653733007162	NLPC_P60 stabilising domain, N term; Region: N_NLPC_P60; pfam12912
653733007163	SH3 domain of the SH3b1 type; Region: SH3_6; pfam12913
653733007164	SH3 domain of SH3b2 type; Region: SH3_7; pfam12914
653733007165	NlpC/P60 family; Region: NLPC_P60; cl17555
653733007166	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
653733007167	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
653733007168	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
653733007169	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
653733007170	active site
653733007171	ribulose/triose binding site [chemical binding]; other site
653733007172	phosphate binding site [ion binding]; other site
653733007173	substrate (anthranilate) binding pocket [chemical binding]; other site
653733007174	product (indole) binding pocket [chemical binding]; other site
653733007175	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
653733007176	active site
653733007177	ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590
653733007178	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
653733007179	ATP binding site [chemical binding]; other site
653733007180	Mg++ binding site [ion binding]; other site
653733007181	motif III; other site
653733007182	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
653733007183	nucleotide binding region [chemical binding]; other site
653733007184	ATP-binding site [chemical binding]; other site
653733007185	Uncharacterized protein, 4-oxalocrotonate tautomerase homolog [General function prediction only]; Region: COG1942
653733007186	active site 1 [active]
653733007187	dimer interface [polypeptide binding]; other site
653733007188	hexamer interface [polypeptide binding]; other site
653733007189	active site 2 [active]
653733007190	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
653733007191	Archaeal ATPase; Region: Arch_ATPase; pfam01637
653733007192	putative 2-aminoethylphosphonate ABC transporter, permease protein; Region: PhnU2; TIGR03262
653733007193	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
653733007194	dimer interface [polypeptide binding]; other site
653733007195	conserved gate region; other site
653733007196	putative PBP binding loops; other site
653733007197	ABC-ATPase subunit interface; other site
653733007198	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
653733007199	dimer interface [polypeptide binding]; other site
653733007200	conserved gate region; other site
653733007201	putative PBP binding loops; other site
653733007202	ABC-ATPase subunit interface; other site
653733007203	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
653733007204	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
653733007205	Walker A/P-loop; other site
653733007206	ATP binding site [chemical binding]; other site
653733007207	Q-loop/lid; other site
653733007208	ABC transporter signature motif; other site
653733007209	Walker B; other site
653733007210	D-loop; other site
653733007211	H-loop/switch region; other site
653733007212	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
653733007213	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
653733007214	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
653733007215	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
653733007216	dimer interface [polypeptide binding]; other site
653733007217	conserved gate region; other site
653733007218	ABC-ATPase subunit interface; other site
653733007219	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
653733007220	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
653733007221	dimer interface [polypeptide binding]; other site
653733007222	conserved gate region; other site
653733007223	ABC-ATPase subunit interface; other site
653733007224	phosphonate ABC transporter, ATP-binding protein; Region: ABC_phnC; TIGR02315
653733007225	ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256
653733007226	Walker A/P-loop; other site
653733007227	ATP binding site [chemical binding]; other site
653733007228	Q-loop/lid; other site
653733007229	ABC transporter signature motif; other site
653733007230	Walker B; other site
653733007231	D-loop; other site
653733007232	H-loop/switch region; other site
653733007233	phosphate/phosphite/phosphonate ABC transporters, periplasmic binding protein; Region: 3A0109s03R; TIGR01098
653733007234	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974
653733007235	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
653733007236	substrate binding pocket [chemical binding]; other site
653733007237	membrane-bound complex binding site; other site
653733007238	hinge residues; other site
653733007239	an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130
653733007240	active site
653733007241	catalytic site [active]
653733007242	substrate binding site [chemical binding]; other site
653733007243	Uncharacterized conserved protein [Function unknown]; Region: COG0397
653733007244	hypothetical protein; Validated; Region: PRK00029
653733007245	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
653733007246	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
653733007247	Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437
653733007248	Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901
653733007249	Polysulphide reductase, NrfD; Region: NrfD; pfam03916
653733007250	Nitrate reductase delta subunit; Region: Nitrate_red_del; pfam02613
653733007251	4Fe-4S binding domain; Region: Fer4; pfam00037
653733007252	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
653733007253	Protein of unknown function (DUF2970); Region: DUF2970; pfam11174
653733007254	NapC/NirT cytochrome c family, N-terminal region; Region: Cytochrom_NNT; pfam03264
653733007255	Cytochrome c552; Region: Cytochrom_C552; pfam02335
653733007256	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
653733007257	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
653733007258	active site
653733007259	phosphorylation site [posttranslational modification]
653733007260	intermolecular recognition site; other site
653733007261	dimerization interface [polypeptide binding]; other site
653733007262	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
653733007263	Walker A motif; other site
653733007264	ATP binding site [chemical binding]; other site
653733007265	Walker B motif; other site
653733007266	arginine finger; other site
653733007267	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
653733007268	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
653733007269	active site
653733007270	PHP-associated; Region: PHP_C; pfam13263
653733007271	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
653733007272	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
653733007273	Metal binding protein HemV-2.  These proteins are predicted to function as initial receptors in ABC transport of metal ions.  They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: HemV-2; cd01147
653733007274	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
653733007275	putative metal binding site [ion binding]; other site
653733007276	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
653733007277	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
653733007278	ABC-ATPase subunit  interface; other site
653733007279	dimer interface [polypeptide binding]; other site
653733007280	putative PBP binding regions; other site
653733007281	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
653733007282	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
653733007283	Walker A/P-loop; other site
653733007284	ATP binding site [chemical binding]; other site
653733007285	Q-loop/lid; other site
653733007286	ABC transporter signature motif; other site
653733007287	Walker B; other site
653733007288	D-loop; other site
653733007289	H-loop/switch region; other site
653733007290	FmdE, Molybdenum formylmethanofuran dehydrogenase operon; Region: FmdE; pfam02663
653733007291	Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; pfam01258
653733007292	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
653733007293	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
653733007294	ABC transporter signature motif; other site
653733007295	Walker B; other site
653733007296	D-loop; other site
653733007297	H-loop/switch region; other site
653733007298	Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542
653733007299	Transposase; Region: DDE_Tnp_ISL3; pfam01610
653733007300	Cache domain; Region: Cache_1; pfam02743
653733007301	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
653733007302	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
653733007303	dimerization interface [polypeptide binding]; other site
653733007304	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
653733007305	dimer interface [polypeptide binding]; other site
653733007306	putative CheW interface [polypeptide binding]; other site
653733007307	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
653733007308	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
653733007309	Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016
653733007310	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
653733007311	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
653733007312	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
653733007313	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
653733007314	glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710
653733007315	active site
653733007316	HIGH motif; other site
653733007317	nucleotide binding site [chemical binding]; other site
653733007318	KMSKS motif; other site
653733007319	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
653733007320	UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253
653733007321	putative NAD(P) binding site [chemical binding]; other site
653733007322	active site
653733007323	putative substrate binding site [chemical binding]; other site
653733007324	tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054
653733007325	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
653733007326	Ligand Binding Site [chemical binding]; other site
653733007327	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
653733007328	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
653733007329	dimer interface [polypeptide binding]; other site
653733007330	pyridoxal 5'-phosphate binding site [chemical binding]; other site
653733007331	catalytic residue [active]
653733007332	Flagellar basal body protein [Cell motility and secretion]; Region: FlgB; COG1815
653733007333	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182
653733007334	flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681
653733007335	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
653733007336	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
653733007337	Flagellar hook-basal body complex protein FliE; Region: FliE; pfam02049
653733007338	flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007
653733007339	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907
653733007340	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
653733007341	flagellar motor switch protein G; Validated; Region: fliG; PRK05686
653733007342	FliG C-terminal domain; Region: FliG_C; pfam01706
653733007343	Flagellar assembly protein FliH; Region: FliH; pfam02108
653733007344	flagellar protein export ATPase FliI; Region: FliI_clade2; TIGR03497
653733007345	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
653733007346	Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136
653733007347	Walker A motif/ATP binding site; other site
653733007348	Walker B motif; other site
653733007349	Uncharacterized conserved protein [Function unknown]; Region: COG3334
653733007350	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
653733007351	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
653733007352	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
653733007353	AMIN domain; Region: AMIN; pfam11741
653733007354	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
653733007355	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
653733007356	active site
653733007357	metal binding site [ion binding]; metal-binding site
653733007358	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
653733007359	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
653733007360	active site
653733007361	substrate binding site [chemical binding]; other site
653733007362	metal binding site [ion binding]; metal-binding site
653733007363	Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805
653733007364	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
653733007365	Walker A motif; other site
653733007366	ATP binding site [chemical binding]; other site
653733007367	Walker B motif; other site
653733007368	DNA topoisomerase I; Validated; Region: PRK06599
653733007369	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
653733007370	active site
653733007371	interdomain interaction site; other site
653733007372	putative metal-binding site [ion binding]; other site
653733007373	nucleotide binding site [chemical binding]; other site
653733007374	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
653733007375	domain I; other site
653733007376	DNA binding groove [nucleotide binding]
653733007377	phosphate binding site [ion binding]; other site
653733007378	domain II; other site
653733007379	domain III; other site
653733007380	nucleotide binding site [chemical binding]; other site
653733007381	catalytic site [active]
653733007382	domain IV; other site
653733007383	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
653733007384	Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551
653733007385	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
653733007386	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
653733007387	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
653733007388	tetramerization interface [polypeptide binding]; other site
653733007389	active site
653733007390	Pantoate-beta-alanine ligase; Region: PanC; cd00560
653733007391	pantoate--beta-alanine ligase; Region: panC; TIGR00018
653733007392	active site
653733007393	ATP-binding site [chemical binding]; other site
653733007394	pantoate-binding site; other site
653733007395	HXXH motif; other site
653733007396	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
653733007397	active site
653733007398	oligomerization interface [polypeptide binding]; other site
653733007399	metal binding site [ion binding]; metal-binding site
653733007400	Sporulation related domain; Region: SPOR; pfam05036
653733007401	arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611
653733007402	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
653733007403	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
653733007404	active site
653733007405	HIGH motif; other site
653733007406	KMSK motif region; other site
653733007407	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
653733007408	tRNA binding surface [nucleotide binding]; other site
653733007409	anticodon binding site; other site
653733007410	GTP-binding protein LepA; Provisional; Region: PRK05433
653733007411	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
653733007412	G1 box; other site
653733007413	putative GEF interaction site [polypeptide binding]; other site
653733007414	GTP/Mg2+ binding site [chemical binding]; other site
653733007415	Switch I region; other site
653733007416	G2 box; other site
653733007417	G3 box; other site
653733007418	Switch II region; other site
653733007419	G4 box; other site
653733007420	G5 box; other site
653733007421	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
653733007422	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
653733007423	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
653733007424	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
653733007425	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
653733007426	Catalytic site [active]
653733007427	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
653733007428	Coenzyme A binding pocket [chemical binding]; other site
653733007429	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
653733007430	Amidohydrolase; Region: Amidohydro_4; pfam13147
653733007431	active site
653733007432	S-adenosylmethionine decarboxylase; Region: AdoMet_dc; cl00687
653733007433	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
653733007434	thiamine phosphate binding site [chemical binding]; other site
653733007435	active site
653733007436	pyrophosphate binding site [ion binding]; other site
653733007437	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
653733007438	16S/18S rRNA binding site [nucleotide binding]; other site
653733007439	S13e-L30e interaction site [polypeptide binding]; other site
653733007440	25S rRNA binding site [nucleotide binding]; other site
653733007441	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
653733007442	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
653733007443	RNase E interface [polypeptide binding]; other site
653733007444	trimer interface [polypeptide binding]; other site
653733007445	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
653733007446	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
653733007447	RNase E interface [polypeptide binding]; other site
653733007448	trimer interface [polypeptide binding]; other site
653733007449	active site
653733007450	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
653733007451	putative nucleic acid binding region [nucleotide binding]; other site
653733007452	G-X-X-G motif; other site
653733007453	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
653733007454	RNA binding site [nucleotide binding]; other site
653733007455	domain interface; other site
653733007456	Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382
653733007457	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
653733007458	GTPase CgtA; Reviewed; Region: obgE; PRK12299
653733007459	GTP1/OBG; Region: GTP1_OBG; pfam01018
653733007460	Obg GTPase; Region: Obg; cd01898
653733007461	G1 box; other site
653733007462	GTP/Mg2+ binding site [chemical binding]; other site
653733007463	Switch I region; other site
653733007464	G2 box; other site
653733007465	G3 box; other site
653733007466	Switch II region; other site
653733007467	G4 box; other site
653733007468	G5 box; other site
653733007469	iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090
653733007470	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
653733007471	DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734
653733007472	phosphoglyceromutase; Provisional; Region: PRK05434
653733007473	Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696
653733007474	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
653733007475	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
653733007476	active site
653733007477	PAS fold; Region: PAS_4; pfam08448
653733007478	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
653733007479	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044
653733007480	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
653733007481	Phosphoglycerate kinase; Region: PGK; pfam00162
653733007482	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
653733007483	substrate binding site [chemical binding]; other site
653733007484	hinge regions; other site
653733007485	ADP binding site [chemical binding]; other site
653733007486	catalytic site [active]
653733007487	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
653733007488	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
653733007489	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
653733007490	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
653733007491	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
653733007492	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
653733007493	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
653733007494	beta subunit interaction interface [polypeptide binding]; other site
653733007495	Walker A motif; other site
653733007496	ATP binding site [chemical binding]; other site
653733007497	Walker B motif; other site
653733007498	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
653733007499	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
653733007500	core domain interface [polypeptide binding]; other site
653733007501	delta subunit interface [polypeptide binding]; other site
653733007502	epsilon subunit interface [polypeptide binding]; other site
653733007503	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
653733007504	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
653733007505	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
653733007506	alpha subunit interaction interface [polypeptide binding]; other site
653733007507	Walker A motif; other site
653733007508	ATP binding site [chemical binding]; other site
653733007509	Walker B motif; other site
653733007510	inhibitor binding site; inhibition site
653733007511	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
653733007512	F0F1 ATP synthase subunit epsilon; Provisional; Region: atpC; PRK13446
653733007513	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
653733007514	gamma subunit interface [polypeptide binding]; other site
653733007515	epsilon subunit interface [polypeptide binding]; other site
653733007516	LBP interface [polypeptide binding]; other site
653733007517	putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347
653733007518	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
653733007519	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
653733007520	RNA binding surface [nucleotide binding]; other site
653733007521	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
653733007522	active site
653733007523	M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cd00596
653733007524	active site
653733007525	Zn binding site [ion binding]; other site
653733007526	Protein of unknown function (DUF3365); Region: DUF3365; pfam11845
653733007527	HAMP domain; Region: HAMP; pfam00672
653733007528	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
653733007529	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
653733007530	dimer interface [polypeptide binding]; other site
653733007531	putative CheW interface [polypeptide binding]; other site
653733007532	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
653733007533	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884
653733007534	active site clefts [active]
653733007535	zinc binding site [ion binding]; other site
653733007536	dimer interface [polypeptide binding]; other site
653733007537	Domain of unknown function (DUF4212); Region: DUF4212; pfam13937
653733007538	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
653733007539	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480
653733007540	Na binding site [ion binding]; other site
653733007541	Protein of unknown function, DUF485; Region: DUF485; pfam04341
653733007542	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
653733007543	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480
653733007544	Na binding site [ion binding]; other site
653733007545	aminotransferase AlaT; Validated; Region: PRK09265
653733007546	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
653733007547	pyridoxal 5'-phosphate binding site [chemical binding]; other site
653733007548	homodimer interface [polypeptide binding]; other site
653733007549	catalytic residue [active]
653733007550	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
653733007551	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
653733007552	ATP-grasp domain; Region: ATP-grasp_4; cl17255
653733007553	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
653733007554	cell division protein FtsA; Region: ftsA; TIGR01174
653733007555	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
653733007556	nucleotide binding site [chemical binding]; other site
653733007557	Cell division protein FtsA; Region: FtsA; pfam14450
653733007558	cell division protein FtsZ; Validated; Region: PRK09330
653733007559	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
653733007560	nucleotide binding site [chemical binding]; other site
653733007561	SulA interaction site; other site
653733007562	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
653733007563	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
653733007564	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
653733007565	S-adenosylmethionine binding site [chemical binding]; other site
653733007566	peptide chain release factor 1; Validated; Region: prfA; PRK00591
653733007567	This domain is found in peptide chain release factors; Region: PCRF; smart00937
653733007568	RF-1 domain; Region: RF-1; pfam00472
653733007569	Predicted CoA-binding protein [General function prediction only]; Region: COG1832
653733007570	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
653733007571	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
653733007572	NAD(P) binding site [chemical binding]; other site
653733007573	active site
653733007574	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
653733007575	RNA methyltransferase, RsmE family; Region: TIGR00046
653733007576	ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517
653733007577	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
653733007578	S-adenosylmethionine binding site [chemical binding]; other site
653733007579	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
653733007580	Telomere recombination; Region: Sua5_yciO_yrdC; cl00305
653733007581	Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663
653733007582	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983
653733007583	Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285
653733007584	Menaquinone biosynthesis; Region: VitK2_biosynth; pfam02621
653733007585	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
653733007586	DEAD/DEAH box helicase; Region: DEAD; pfam00270
653733007587	ATP binding site [chemical binding]; other site
653733007588	DEAD_2; Region: DEAD_2; pfam06733
653733007589	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
653733007590	rod shape-determining protein MreB; Provisional; Region: PRK13927
653733007591	MreB and similar proteins; Region: MreB_like; cd10225
653733007592	nucleotide binding site [chemical binding]; other site
653733007593	Mg binding site [ion binding]; other site
653733007594	putative protofilament interaction site [polypeptide binding]; other site
653733007595	RodZ interaction site [polypeptide binding]; other site
653733007596	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
653733007597	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
653733007598	homotetramer interface [polypeptide binding]; other site
653733007599	ligand binding site [chemical binding]; other site
653733007600	catalytic site [active]
653733007601	NAD binding site [chemical binding]; other site
653733007602	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
653733007603	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
653733007604	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
653733007605	Helix-turn-helix domain; Region: HTH_37; pfam13744
653733007606	anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG2; TIGR02495
653733007607	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
653733007608	FeS/SAM binding site; other site
653733007609	Anaerobic ribonucleoside-triphosphate reductase; Region: NRDD; pfam13597
653733007610	anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK08270
653733007611	ATP cone domain; Region: ATP-cone; pfam03477
653733007612	Class III ribonucleotide reductase; Region: RNR_III; cd01675
653733007613	effector binding site; other site
653733007614	active site
653733007615	Zn binding site [ion binding]; other site
653733007616	glycine loop; other site
653733007617	Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907
653733007618	Ferritin-like domain; Region: Ferritin; pfam00210
653733007619	heme binding site [chemical binding]; other site
653733007620	ferroxidase pore; other site
653733007621	ferroxidase diiron center [ion binding]; other site
653733007622	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
653733007623	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
653733007624	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
653733007625	DNA binding residues [nucleotide binding]
653733007626	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
653733007627	FecR protein; Region: FecR; pfam04773
653733007628	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
653733007629	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
653733007630	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
653733007631	Secretin and TonB N terminus short domain; Region: STN; smart00965
653733007632	TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786
653733007633	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
653733007634	N-terminal plug; other site
653733007635	ligand-binding site [chemical binding]; other site
653733007636	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cl17457
653733007637	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
653733007638	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
653733007639	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
653733007640	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338
653733007641	RloB-like protein; Region: RloB; pfam13707
653733007642	AAA domain; Region: AAA_21; pfam13304
653733007643	Nitroreductase-like family 4.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140
653733007644	dimer interface [polypeptide binding]; other site
653733007645	FMN binding site [chemical binding]; other site
653733007646	M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647
653733007647	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007
653733007648	metal binding site [ion binding]; metal-binding site
653733007649	putative dimer interface [polypeptide binding]; other site
653733007650	lipoprotein chaperone; Reviewed; Region: lolA; PRK00031
653733007651	Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548
653733007652	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
653733007653	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
653733007654	S-adenosylmethionine binding site [chemical binding]; other site
653733007655	4-hydroxythreonine-4-phosphate dehydrogenase; Region: pdxA; TIGR00557
653733007656	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
653733007657	CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559
653733007658	DEAD-like helicases superfamily; Region: DEXDc; smart00487
653733007659	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
653733007660	ATP binding site [chemical binding]; other site
653733007661	putative Mg++ binding site [ion binding]; other site
653733007662	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
653733007663	nucleotide binding region [chemical binding]; other site
653733007664	ATP-binding site [chemical binding]; other site
653733007665	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
653733007666	TRAP transporter, 4TM/12TM fusion protein; Region: TRAP_fused; TIGR02123
653733007667	DctM-like transporters; Region: DctM; pfam06808
653733007668	TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358
653733007669	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
653733007670	transcription termination factor Rho; Provisional; Region: rho; PRK09376
653733007671	Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498
653733007672	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
653733007673	RNA binding site [nucleotide binding]; other site
653733007674	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
653733007675	multimer interface [polypeptide binding]; other site
653733007676	Walker A motif; other site
653733007677	ATP binding site [chemical binding]; other site
653733007678	Walker B motif; other site
653733007679	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019
653733007680	FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847
653733007681	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
653733007682	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
653733007683	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
653733007684	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
653733007685	active site
653733007686	recombination regulator RecX; Reviewed; Region: recX; PRK00117
653733007687	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
653733007688	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
653733007689	Ligand Binding Site [chemical binding]; other site
653733007690	TilS substrate C-terminal domain; Region: TilS_C; smart00977
653733007691	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
653733007692	active site
653733007693	FtsH Extracellular; Region: FtsH_ext; pfam06480
653733007694	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
653733007695	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
653733007696	Walker A motif; other site
653733007697	ATP binding site [chemical binding]; other site
653733007698	Walker B motif; other site
653733007699	arginine finger; other site
653733007700	Peptidase family M41; Region: Peptidase_M41; pfam01434
653733007701	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
653733007702	dihydropteroate synthase; Region: DHPS; TIGR01496
653733007703	substrate binding pocket [chemical binding]; other site
653733007704	dimer interface [polypeptide binding]; other site
653733007705	inhibitor binding site; inhibition site
653733007706	Uncharacterized conserved protein [Function unknown]; Region: COG1624
653733007707	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
653733007708	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14314
653733007709	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
653733007710	active site
653733007711	substrate binding site [chemical binding]; other site
653733007712	metal binding site [ion binding]; metal-binding site
653733007713	Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003
653733007714	active site
653733007715	hydrophilic channel; other site
653733007716	dimerization interface [polypeptide binding]; other site
653733007717	catalytic residues [active]
653733007718	active site lid [active]
653733007719	Phosphopantetheinyl transferase (holo-ACP synthase) [Lipid metabolism]; Region: AcpS; COG0736
653733007720	CTP synthetase; Validated; Region: pyrG; PRK05380
653733007721	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
653733007722	Catalytic site [active]
653733007723	active site
653733007724	UTP binding site [chemical binding]; other site
653733007725	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
653733007726	active site
653733007727	putative oxyanion hole; other site
653733007728	catalytic triad [active]
653733007729	Family of unknown function (DUF490); Region: DUF490; pfam04357
653733007730	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
653733007731	Surface antigen; Region: Bac_surface_Ag; pfam01103
653733007732	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
653733007733	ResB-like family; Region: ResB; pfam05140
653733007734	ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125
653733007735	cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144
653733007736	putative heme d1 biosynthesis radical SAM protein NirJ2; Region: rSAM_NirJ2; TIGR04055
653733007737	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
653733007738	FeS/SAM binding site; other site
653733007739	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
653733007740	methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252
653733007741	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
653733007742	substrate binding site [chemical binding]; other site
653733007743	active site
653733007744	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
653733007745	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
653733007746	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
653733007747	tRNA; other site
653733007748	putative tRNA binding site [nucleotide binding]; other site
653733007749	putative NADP binding site [chemical binding]; other site
653733007750	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
653733007751	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
653733007752	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494
653733007753	domain interfaces; other site
653733007754	active site
653733007755	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
653733007756	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
653733007757	catalytic residues [active]
653733007758	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
653733007759	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
653733007760	Zn2+ binding site [ion binding]; other site
653733007761	Mg2+ binding site [ion binding]; other site
653733007762	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
653733007763	synthetase active site [active]
653733007764	NTP binding site [chemical binding]; other site
653733007765	metal binding site [ion binding]; metal-binding site
653733007766	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
653733007767	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
653733007768	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
653733007769	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
653733007770	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
653733007771	Protein of unknown function DUF262; Region: DUF262; pfam03235
653733007772	Uncharacterized conserved protein [Function unknown]; Region: COG1479
653733007773	Protein of unknown function DUF262; Region: DUF262; pfam03235
653733007774	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
653733007775	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
653733007776	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
653733007777	ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482
653733007778	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
653733007779	MarR family; Region: MarR_2; pfam12802
653733007780	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
653733007781	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
653733007782	HlyD family secretion protein; Region: HlyD_3; pfam13437
653733007783	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
653733007784	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
653733007785	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143
653733007786	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884
653733007787	active site clefts [active]
653733007788	zinc binding site [ion binding]; other site
653733007789	dimer interface [polypeptide binding]; other site
653733007790	AIR carboxylase; Region: AIRC; pfam00731
653733007791	Uncharacterized conserved protein (DUF2294); Region: DUF2294; pfam10057
653733007792	membrane ATPase/protein kinase; Provisional; Region: PRK09435
653733007793	The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114
653733007794	Walker A; other site
653733007795	methylmalonyl-CoA mutase; Reviewed; Region: PRK09426
653733007796	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679
653733007797	active site
653733007798	substrate binding site [chemical binding]; other site
653733007799	coenzyme B12 binding site [chemical binding]; other site
653733007800	methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071
653733007801	B12 binding site [chemical binding]; other site
653733007802	cobalt ligand [ion binding]; other site
653733007803	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
653733007804	ATP-grasp domain; Region: ATP-grasp_4; cl17255
653733007805	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
653733007806	Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511
653733007807	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
653733007808	carboxyltransferase (CT) interaction site; other site
653733007809	biotinylation site [posttranslational modification]; other site
653733007810	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
653733007811	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
653733007812	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
653733007813	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
653733007814	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
653733007815	preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585
653733007816	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
653733007817	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
653733007818	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
653733007819	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
653733007820	Protein export membrane protein; Region: SecD_SecF; pfam02355
653733007821	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
653733007822	FOG: CBS domain [General function prediction only]; Region: COG0517
653733007823	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
653733007824	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
653733007825	PilZ domain; Region: PilZ; pfam07238
653733007826	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 [Coenzyme metabolism]; Region: ThiF; COG0476
653733007827	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
653733007828	ATP binding site [chemical binding]; other site
653733007829	substrate interface [chemical binding]; other site
653733007830	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
653733007831	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
653733007832	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
653733007833	catalytic residue [active]
653733007834	Fic family protein [Function unknown]; Region: COG3177
653733007835	Fic/DOC family N-terminal; Region: Fic_N; pfam13784
653733007836	Fic/DOC family; Region: Fic; pfam02661
653733007837	Domain of unknown function (DUF2007); Region: DUF2007; pfam09413
653733007838	Protein of unknown function (DUF1016); Region: DUF1016; pfam06250
653733007839	Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319
653733007840	Putative transposase; Region: Y2_Tnp; pfam04986
653733007841	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
653733007842	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
653733007843	active site
653733007844	Int/Topo IB signature motif; other site
653733007845	DNA binding site [nucleotide binding]
653733007846	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
653733007847	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
653733007848	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
653733007849	protein binding site [polypeptide binding]; other site
653733007850	Predicted restriction endonuclease [Defense mechanisms]; Region: COG3183
653733007851	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
653733007852	active site
653733007853	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
653733007854	Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016
653733007855	PilZ domain; Region: PilZ; pfam07238
653733007856	heat shock protein 90; Provisional; Region: PRK05218
653733007857	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
653733007858	histidinol-phosphate phosphatase family domain; Region: Histidinol-ppas; TIGR01656
653733007859	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
653733007860	active site
653733007861	motif I; other site
653733007862	motif II; other site
653733007863	chaperone protein DnaJ; Provisional; Region: PRK10767
653733007864	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
653733007865	HSP70 interaction site [polypeptide binding]; other site
653733007866	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
653733007867	substrate binding site [polypeptide binding]; other site
653733007868	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
653733007869	Zn binding sites [ion binding]; other site
653733007870	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
653733007871	dimer interface [polypeptide binding]; other site
653733007872	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
653733007873	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
653733007874	nucleotide binding site [chemical binding]; other site
653733007875	NEF interaction site [polypeptide binding]; other site
653733007876	SBD interface [polypeptide binding]; other site
653733007877	GrpE; Region: GrpE; pfam01025
653733007878	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
653733007879	dimer interface [polypeptide binding]; other site
653733007880	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
653733007881	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
653733007882	O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873
653733007883	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
653733007884	homodimer interface [polypeptide binding]; other site
653733007885	substrate-cofactor binding pocket; other site
653733007886	pyridoxal 5'-phosphate binding site [chemical binding]; other site
653733007887	catalytic residue [active]
653733007888	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666
653733007889	Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740
653733007890	Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600
653733007891	4Fe-4S dicluster domain; Region: Fer4_10; pfam13237
653733007892	4Fe-4S binding domain; Region: Fer4; pfam00037
653733007893	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
653733007894	FMN binding site [chemical binding]; other site
653733007895	dimer interface [polypeptide binding]; other site
653733007896	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
653733007897	sucrose synthase; Region: sucr_synth; TIGR02470
653733007898	This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800
653733007899	putative ADP-binding pocket [chemical binding]; other site
653733007900	This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800
653733007901	sucrose-phosphate synthase, putative, glycosyltransferase domain; Region: sucr_P_syn_N; TIGR02472
653733007902	putative ADP-binding pocket [chemical binding]; other site
653733007903	sucrose phosphate synthase, sucrose phosphatase-like domain, bacterial; Region: sucr_syn_bact_C; TIGR02471
653733007904	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
653733007905	active site
653733007906	motif I; other site
653733007907	motif II; other site
653733007908	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
653733007909	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
653733007910	putative substrate binding site [chemical binding]; other site
653733007911	putative ATP binding site [chemical binding]; other site
653733007912	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
653733007913	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
653733007914	motif II; other site
653733007915	Response regulator receiver domain; Region: Response_reg; pfam00072
653733007916	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
653733007917	active site
653733007918	phosphorylation site [posttranslational modification]
653733007919	intermolecular recognition site; other site
653733007920	dimerization interface [polypeptide binding]; other site
653733007921	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
653733007922	dimerization interface [polypeptide binding]; other site
653733007923	putative DNA binding site [nucleotide binding]; other site
653733007924	putative Zn2+ binding site [ion binding]; other site
653733007925	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
653733007926	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
653733007927	dimer interface [polypeptide binding]; other site
653733007928	phosphorylation site [posttranslational modification]
653733007929	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
653733007930	ATP binding site [chemical binding]; other site
653733007931	Mg2+ binding site [ion binding]; other site
653733007932	G-X-G motif; other site
653733007933	nicotinate phosphoribosyltransferase; Provisional; Region: PRK05321
653733007934	nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514
653733007935	active site
653733007936	Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011
653733007937	Isochorismatase family; Region: Isochorismatase; pfam00857
653733007938	catalytic triad [active]
653733007939	metal binding site [ion binding]; metal-binding site
653733007940	conserved cis-peptide bond; other site
653733007941	Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271
653733007942	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
653733007943	putative substrate translocation pore; other site
653733007944	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
653733007945	F plasmid transfer operon, TraF, protein; Region: TraF_2; pfam13729
653733007946	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
653733007947	hypothetical protein; Provisional; Region: PRK11820
653733007948	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
653733007949	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
653733007950	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
653733007951	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
653733007952	catalytic site [active]
653733007953	G-X2-G-X-G-K; other site
653733007954	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
653733007955	Flavoprotein; Region: Flavoprotein; pfam02441
653733007956	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
653733007957	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
653733007958	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
653733007959	Fe-S cluster binding site [ion binding]; other site
653733007960	active site
653733007961	MOSC domain; Region: MOSC; pfam03473
653733007962	Response regulator receiver domain; Region: Response_reg; pfam00072
653733007963	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
653733007964	active site
653733007965	phosphorylation site [posttranslational modification]
653733007966	intermolecular recognition site; other site
653733007967	dimerization interface [polypeptide binding]; other site
653733007968	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
653733007969	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
653733007970	metal binding site [ion binding]; metal-binding site
653733007971	active site
653733007972	I-site; other site
653733007973	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
653733007974	Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1),  6-pyrovoyl...; Region: TFold; cl00263
653733007975	putative menaquinone biosynthesis protein, SCO4494 family; Region: mena_SCO4494; TIGR03700
653733007976	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
653733007977	FeS/SAM binding site; other site
653733007978	Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility; Region: MEMO_like; cd07361
653733007979	putative ligand binding pocket/active site [active]
653733007980	putative metal binding site [ion binding]; other site
653733007981	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
653733007982	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
653733007983	putative dimer interface [polypeptide binding]; other site
653733007984	Found in ATP-dependent protease La (LON); Region: LON; smart00464
653733007985	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
653733007986	Found in ATP-dependent protease La (LON); Region: LON; smart00464
653733007987	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
653733007988	Walker A motif; other site
653733007989	ATP binding site [chemical binding]; other site
653733007990	Walker B motif; other site
653733007991	arginine finger; other site
653733007992	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
653733007993	Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; pfam09835
653733007994	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
653733007995	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
653733007996	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
653733007997	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
653733007998	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
653733007999	putative CheA interaction surface; other site
653733008000	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
653733008001	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
653733008002	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
653733008003	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
653733008004	active site
653733008005	dimer interface [polypeptide binding]; other site
653733008006	motif 1; other site
653733008007	motif 2; other site
653733008008	motif 3; other site
653733008009	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
653733008010	anticodon binding site; other site
653733008011	translation initiation factor IF-3; Region: infC; TIGR00168
653733008012	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
653733008013	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
653733008014	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
653733008015	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
653733008016	23S rRNA binding site [nucleotide binding]; other site
653733008017	L21 binding site [polypeptide binding]; other site
653733008018	L13 binding site [polypeptide binding]; other site
653733008019	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
653733008020	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
653733008021	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
653733008022	dimer interface [polypeptide binding]; other site
653733008023	motif 1; other site
653733008024	active site
653733008025	motif 2; other site
653733008026	motif 3; other site
653733008027	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
653733008028	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
653733008029	putative tRNA-binding site [nucleotide binding]; other site
653733008030	B3/4 domain; Region: B3_4; pfam03483
653733008031	tRNA synthetase B5 domain; Region: B5; smart00874
653733008032	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
653733008033	dimer interface [polypeptide binding]; other site
653733008034	motif 1; other site
653733008035	motif 3; other site
653733008036	motif 2; other site
653733008037	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896
653733008038	proteasome-activating nucleotidase; Provisional; Region: PRK03992
653733008039	Cell division protein ZapA; Region: ZapA; pfam05164
653733008040	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
653733008041	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
653733008042	phosphodiesterase; Provisional; Region: PRK12704
653733008043	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
653733008044	Zn2+ binding site [ion binding]; other site
653733008045	Mg2+ binding site [ion binding]; other site
653733008046	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258
653733008047	MOSC domain; Region: MOSC; pfam03473
653733008048	3-alpha domain; Region: 3-alpha; pfam03475
653733008049	nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034
653733008050	Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223
653733008051	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
653733008052	putative substrate translocation pore; other site
653733008053	Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665
653733008054	Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958
653733008055	Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140
653733008056	Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013
653733008057	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750
653733008058	[4Fe-4S] binding site [ion binding]; other site
653733008059	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
653733008060	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
653733008061	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
653733008062	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776
653733008063	molybdopterin cofactor binding site; other site
653733008064	Protein of unknown function (DUF1007); Region: DUF1007; cl01487
653733008065	High-affinity nickel-transport protein; Region: NicO; cl00964
653733008066	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
653733008067	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
653733008068	active site
653733008069	phosphorylation site [posttranslational modification]
653733008070	intermolecular recognition site; other site
653733008071	dimerization interface [polypeptide binding]; other site
653733008072	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
653733008073	Walker A motif; other site
653733008074	ATP binding site [chemical binding]; other site
653733008075	Walker B motif; other site
653733008076	arginine finger; other site
653733008077	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
653733008078	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
653733008079	dimer interface [polypeptide binding]; other site
653733008080	phosphorylation site [posttranslational modification]
653733008081	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
653733008082	ATP binding site [chemical binding]; other site
653733008083	Mg2+ binding site [ion binding]; other site
653733008084	G-X-G motif; other site
653733008085	Domain of unknown function (DUF4405); Region: DUF4405; pfam14358
653733008086	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
653733008087	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
653733008088	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
653733008089	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
653733008090	Transcriptional regulators [Transcription]; Region: FadR; COG2186
653733008091	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
653733008092	DNA-binding site [nucleotide binding]; DNA binding site
653733008093	FCD domain; Region: FCD; pfam07729
653733008094	Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015
653733008095	Adenylsuccinate lyase (ASL)_subgroup 2; Region: Adenylsuccinate_lyase_2; cd03302
653733008096	tetramer interface [polypeptide binding]; other site
653733008097	active site
653733008098	YfaZ precursor; Region: YfaZ; pfam07437
653733008099	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
653733008100	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
653733008101	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
653733008102	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
653733008103	active site
653733008104	substrate binding site [chemical binding]; other site
653733008105	cosubstrate binding site; other site
653733008106	catalytic site [active]
653733008107	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
653733008108	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
653733008109	dimerization interface [polypeptide binding]; other site
653733008110	putative ATP binding site [chemical binding]; other site
653733008111	Response regulator receiver domain; Region: Response_reg; pfam00072
653733008112	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
653733008113	active site
653733008114	phosphorylation site [posttranslational modification]
653733008115	intermolecular recognition site; other site
653733008116	dimerization interface [polypeptide binding]; other site
653733008117	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286
653733008118	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
653733008119	Zn2+ binding site [ion binding]; other site
653733008120	Mg2+ binding site [ion binding]; other site
653733008121	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
653733008122	bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238
653733008123	Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576
653733008124	substrate binding site [chemical binding]; other site
653733008125	Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581
653733008126	substrate binding site [chemical binding]; other site
653733008127	ligand binding site [chemical binding]; other site
653733008128	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
653733008129	dTDP-glucose 4,6 dehydratase; Provisional; Region: PRK10084
653733008130	NAD binding site [chemical binding]; other site
653733008131	substrate binding site [chemical binding]; other site
653733008132	homodimer interface [polypeptide binding]; other site
653733008133	active site
653733008134	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
653733008135	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
653733008136	NADP binding site [chemical binding]; other site
653733008137	active site
653733008138	putative substrate binding site [chemical binding]; other site
653733008139	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908
653733008140	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
653733008141	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
653733008142	substrate binding site; other site
653733008143	tetramer interface; other site
653733008144	mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479
653733008145	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
653733008146	Substrate binding site; other site
653733008147	Cupin domain; Region: Cupin_2; cl17218
653733008148	Uncharacterized conserved protein (DUF2304); Region: DUF2304; cl01034
653733008149	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
653733008150	Ligand binding site; other site
653733008151	Putative Catalytic site; other site
653733008152	DXD motif; other site
653733008153	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
653733008154	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
653733008155	Probable Catalytic site; other site
653733008156	metal-binding site
653733008157	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
653733008158	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196
653733008159	Probable Catalytic site; other site
653733008160	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
653733008161	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
653733008162	Methyltransferase domain; Region: Methyltransf_31; pfam13847
653733008163	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
653733008164	S-adenosylmethionine binding site [chemical binding]; other site
653733008165	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
653733008166	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
653733008167	inhibitor-cofactor binding pocket; inhibition site
653733008168	pyridoxal 5'-phosphate binding site [chemical binding]; other site
653733008169	catalytic residue [active]
653733008170	Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535
653733008171	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
653733008172	FeS/SAM binding site; other site
653733008173	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
653733008174	Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128
653733008175	TPR repeat; Region: TPR_11; pfam13414
653733008176	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
653733008177	binding surface
653733008178	TPR motif; other site
653733008179	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
653733008180	binding surface
653733008181	TPR repeat; Region: TPR_11; pfam13414
653733008182	TPR motif; other site
653733008183	TPR repeat; Region: TPR_11; pfam13414
653733008184	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
653733008185	binding surface
653733008186	TPR motif; other site
653733008187	Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435
653733008188	Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168
653733008189	heme-binding residues [chemical binding]; other site
653733008190	Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435
653733008191	Winged helix-turn helix; Region: HTH_29; pfam13551
653733008192	Homeodomain-like domain; Region: HTH_23; pfam13384
653733008193	Homeodomain-like domain; Region: HTH_32; pfam13565
653733008194	DDE superfamily endonuclease; Region: DDE_3; pfam13358
653733008195	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
653733008196	PAS fold; Region: PAS_3; pfam08447
653733008197	putative active site [active]
653733008198	heme pocket [chemical binding]; other site
653733008199	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
653733008200	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
653733008201	dimer interface [polypeptide binding]; other site
653733008202	phosphorylation site [posttranslational modification]
653733008203	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
653733008204	ATP binding site [chemical binding]; other site
653733008205	Mg2+ binding site [ion binding]; other site
653733008206	G-X-G motif; other site
653733008207	Response regulator receiver domain; Region: Response_reg; pfam00072
653733008208	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
653733008209	active site
653733008210	phosphorylation site [posttranslational modification]
653733008211	intermolecular recognition site; other site
653733008212	dimerization interface [polypeptide binding]; other site
653733008213	Response regulator receiver domain; Region: Response_reg; pfam00072
653733008214	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
653733008215	active site
653733008216	phosphorylation site [posttranslational modification]
653733008217	intermolecular recognition site; other site
653733008218	dimerization interface [polypeptide binding]; other site
653733008219	Response regulator receiver domain; Region: Response_reg; pfam00072
653733008220	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
653733008221	active site
653733008222	phosphorylation site [posttranslational modification]
653733008223	intermolecular recognition site; other site
653733008224	dimerization interface [polypeptide binding]; other site
653733008225	Response regulator receiver domain; Region: Response_reg; pfam00072
653733008226	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
653733008227	active site
653733008228	phosphorylation site [posttranslational modification]
653733008229	intermolecular recognition site; other site
653733008230	dimerization interface [polypeptide binding]; other site
653733008231	Response regulator receiver domain; Region: Response_reg; pfam00072
653733008232	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
653733008233	active site
653733008234	phosphorylation site [posttranslational modification]
653733008235	intermolecular recognition site; other site
653733008236	dimerization interface [polypeptide binding]; other site
653733008237	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
653733008238	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
653733008239	metal binding site [ion binding]; metal-binding site
653733008240	active site
653733008241	I-site; other site
653733008242	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
653733008243	putative binding surface; other site
653733008244	active site
653733008245	Response regulator receiver domain; Region: Response_reg; pfam00072
653733008246	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
653733008247	active site
653733008248	phosphorylation site [posttranslational modification]
653733008249	intermolecular recognition site; other site
653733008250	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
653733008251	glycogen synthase; Provisional; Region: glgA; PRK00654
653733008252	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
653733008253	ADP-binding pocket [chemical binding]; other site
653733008254	homodimer interface [polypeptide binding]; other site
653733008255	Fic family protein [Function unknown]; Region: COG3177
653733008256	Fic/DOC family; Region: Fic; pfam02661
653733008257	Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437
653733008258	Polysulphide reductase, NrfD; Region: NrfD; pfam03916
653733008259	Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901
653733008260	tetrathionate reductase subunit A; Provisional; Region: PRK14991
653733008261	The MopB_Tetrathionate-Ra CD contains tetrathionate reductase, subunit A, (TtrA) and other related proteins. The Salmonella enterica tetrathionate reductase catalyses the reduction of trithionate but not sulfur or thiosulfate. Members of this CD belong...; Region: MopB_Tetrathionate-Ra; cd02758
653733008262	putative [Fe4-S4] binding site [ion binding]; other site
653733008263	putative molybdopterin cofactor binding site [chemical binding]; other site
653733008264	This CD contains the molybdopterin_binding C-terminal (MopB_CT) region of tetrathionate reductase, subunit A, (TtrA); respiratory arsenate As(V) reductase, catalytic subunit (ArrA); and other related proteins; Region: MopB_CT_Tetrathionate_Arsenate-R; cd02780
653733008265	putative molybdopterin cofactor binding site; other site
653733008266	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
653733008267	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
653733008268	active site
653733008269	phosphorylation site [posttranslational modification]
653733008270	intermolecular recognition site; other site
653733008271	dimerization interface [polypeptide binding]; other site
653733008272	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
653733008273	DNA binding site [nucleotide binding]
653733008274	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
653733008275	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
653733008276	dimer interface [polypeptide binding]; other site
653733008277	phosphorylation site [posttranslational modification]
653733008278	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
653733008279	ATP binding site [chemical binding]; other site
653733008280	Mg2+ binding site [ion binding]; other site
653733008281	G-X-G motif; other site
653733008282	Ammonium Transporter Family; Region: Ammonium_transp; cl03012
653733008283	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
653733008284	dimerization interface [polypeptide binding]; other site
653733008285	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
653733008286	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
653733008287	dimer interface [polypeptide binding]; other site
653733008288	putative CheW interface [polypeptide binding]; other site
653733008289	hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413
653733008290	Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518
653733008291	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
653733008292	deoxyribodipyrimidine photolyase; Provisional; Region: PRK10674
653733008293	DNA photolyase; Region: DNA_photolyase; pfam00875
653733008294	Uncharacterized protein involved in tolerance to divalent cations [Inorganic ion transport and metabolism]; Region: CutA; COG1324
653733008295	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537
653733008296	homodimer interface [polypeptide binding]; other site
653733008297	chemical substrate binding site [chemical binding]; other site
653733008298	oligomer interface [polypeptide binding]; other site
653733008299	metal binding site [ion binding]; metal-binding site
653733008300	ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109
653733008301	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561
653733008302	homodimer interface [polypeptide binding]; other site
653733008303	Walker A motif; other site
653733008304	ATP binding site [chemical binding]; other site
653733008305	hydroxycobalamin binding site [chemical binding]; other site
653733008306	Walker B motif; other site
653733008307	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
653733008308	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
653733008309	G1 box; other site
653733008310	putative GEF interaction site [polypeptide binding]; other site
653733008311	GTP/Mg2+ binding site [chemical binding]; other site
653733008312	Switch I region; other site
653733008313	G2 box; other site
653733008314	G3 box; other site
653733008315	Switch II region; other site
653733008316	G4 box; other site
653733008317	G5 box; other site
653733008318	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
653733008319	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
653733008320	uncharacterized domain; Region: TIGR00702
653733008321	YcaO-like family; Region: YcaO; pfam02624
653733008322	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
653733008323	substrate binding site; other site
653733008324	dimer interface; other site
653733008325	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214
653733008326	active site
653733008327	intersubunit interface [polypeptide binding]; other site
653733008328	Zn2+ binding site [ion binding]; other site
653733008329	Acylphosphatases [Energy production and conversion]; Region: AcyP; COG1254
653733008330	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
653733008331	PAS fold; Region: PAS_3; pfam08447
653733008332	putative active site [active]
653733008333	heme pocket [chemical binding]; other site
653733008334	PAS domain S-box; Region: sensory_box; TIGR00229
653733008335	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
653733008336	putative active site [active]
653733008337	heme pocket [chemical binding]; other site
653733008338	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
653733008339	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
653733008340	ATP binding site [chemical binding]; other site
653733008341	Mg2+ binding site [ion binding]; other site
653733008342	G-X-G motif; other site
653733008343	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
653733008344	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
653733008345	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
653733008346	Response regulator receiver domain; Region: Response_reg; pfam00072
653733008347	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
653733008348	active site
653733008349	phosphorylation site [posttranslational modification]
653733008350	intermolecular recognition site; other site
653733008351	dimerization interface [polypeptide binding]; other site
653733008352	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
653733008353	PAS fold; Region: PAS_3; pfam08447
653733008354	putative active site [active]
653733008355	heme pocket [chemical binding]; other site
653733008356	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
653733008357	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
653733008358	putative active site [active]
653733008359	heme pocket [chemical binding]; other site
653733008360	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
653733008361	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
653733008362	putative active site [active]
653733008363	heme pocket [chemical binding]; other site
653733008364	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
653733008365	dimer interface [polypeptide binding]; other site
653733008366	phosphorylation site [posttranslational modification]
653733008367	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
653733008368	ATP binding site [chemical binding]; other site
653733008369	Mg2+ binding site [ion binding]; other site
653733008370	G-X-G motif; other site
653733008371	Response regulator receiver domain; Region: Response_reg; pfam00072
653733008372	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
653733008373	active site
653733008374	phosphorylation site [posttranslational modification]
653733008375	intermolecular recognition site; other site
653733008376	dimerization interface [polypeptide binding]; other site
653733008377	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
653733008378	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
653733008379	dimer interface [polypeptide binding]; other site
653733008380	phosphorylation site [posttranslational modification]
653733008381	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
653733008382	ATP binding site [chemical binding]; other site
653733008383	Mg2+ binding site [ion binding]; other site
653733008384	G-X-G motif; other site
653733008385	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
653733008386	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
653733008387	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
653733008388	dimer interface [polypeptide binding]; other site
653733008389	phosphorylation site [posttranslational modification]
653733008390	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
653733008391	ATP binding site [chemical binding]; other site
653733008392	Mg2+ binding site [ion binding]; other site
653733008393	G-X-G motif; other site
653733008394	cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160
653733008395	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
653733008396	Walker A/P-loop; other site
653733008397	ATP binding site [chemical binding]; other site
653733008398	Q-loop/lid; other site
653733008399	ABC transporter signature motif; other site
653733008400	Walker B; other site
653733008401	D-loop; other site
653733008402	H-loop/switch region; other site
653733008403	cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11174
653733008404	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
653733008405	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
653733008406	Walker A/P-loop; other site
653733008407	ATP binding site [chemical binding]; other site
653733008408	Q-loop/lid; other site
653733008409	ABC transporter signature motif; other site
653733008410	Walker B; other site
653733008411	D-loop; other site
653733008412	H-loop/switch region; other site
653733008413	Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824
653733008414	PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274
653733008415	PhnA protein; Region: PhnA; pfam03831
653733008416	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
653733008417	endonuclease III; Region: ENDO3c; smart00478
653733008418	minor groove reading motif; other site
653733008419	helix-hairpin-helix signature motif; other site
653733008420	substrate binding pocket [chemical binding]; other site
653733008421	active site
653733008422	Part of AAA domain; Region: AAA_19; pfam13245
653733008423	UvrD-like helicase C-terminal domain; Region: UvrD_C; pfam13361
653733008424	Family description; Region: UvrD_C_2; pfam13538
653733008425	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
653733008426	probable DNA repair protein; Region: TIGR03623
653733008427	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
653733008428	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
653733008429	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
653733008430	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
653733008431	Uncharacterized protein conserved in bacteria (DUF2219); Region: DUF2219; pfam09982
653733008432	Outer membrane efflux protein; Region: OEP; pfam02321
653733008433	Outer membrane efflux protein; Region: OEP; pfam02321
653733008434	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
653733008435	Protein export membrane protein; Region: SecD_SecF; cl14618
653733008436	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
653733008437	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
653733008438	HlyD family secretion protein; Region: HlyD_3; pfam13437
653733008439	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
653733008440	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
653733008441	Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226
653733008442	CHASE4 domain; Region: CHASE4; pfam05228
653733008443	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
653733008444	PAS domain; Region: PAS_9; pfam13426
653733008445	putative active site [active]
653733008446	heme pocket [chemical binding]; other site
653733008447	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
653733008448	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
653733008449	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
653733008450	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
653733008451	dimer interface [polypeptide binding]; other site
653733008452	phosphorylation site [posttranslational modification]
653733008453	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
653733008454	ATP binding site [chemical binding]; other site
653733008455	Mg2+ binding site [ion binding]; other site
653733008456	G-X-G motif; other site
653733008457	uncharacterized radical SAM protein YgiQ; Region: SAM_YgiQ; TIGR03904
653733008458	Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497
653733008459	Domain of unknown function (DUF3362); Region: DUF3362; pfam11842
653733008460	Predicted inhibitor of MCP methylation, homolog of CheC [Cell motility and secretion]; Region: COG1406
653733008461	Chemotaxis phosphatase CheX; Region: CheX; pfam13690
653733008462	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
653733008463	PAS fold; Region: PAS_3; pfam08447
653733008464	putative active site [active]
653733008465	heme pocket [chemical binding]; other site
653733008466	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
653733008467	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
653733008468	dimer interface [polypeptide binding]; other site
653733008469	phosphorylation site [posttranslational modification]
653733008470	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
653733008471	ATP binding site [chemical binding]; other site
653733008472	G-X-G motif; other site
653733008473	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
653733008474	S-adenosylmethionine binding site [chemical binding]; other site
653733008475	sensory histidine kinase UhpB; Provisional; Region: PRK11644
653733008476	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
653733008477	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
653733008478	Walker A/P-loop; other site
653733008479	ATP binding site [chemical binding]; other site
653733008480	Q-loop/lid; other site
653733008481	ABC transporter signature motif; other site
653733008482	Walker B; other site
653733008483	H-loop/switch region; other site
653733008484	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
653733008485	Domain of unknown function (DUF1858); Region: DUF1858; pfam08984
653733008486	Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343
653733008487	Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049
653733008488	Cache domain; Region: Cache_2; cl07034
653733008489	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
653733008490	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
653733008491	ATP binding site [chemical binding]; other site
653733008492	Mg2+ binding site [ion binding]; other site
653733008493	G-X-G motif; other site
653733008494	Beta-lactamase; Region: Beta-lactamase; pfam00144
653733008495	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
653733008496	argininosuccinate lyase; Provisional; Region: PRK00855
653733008497	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
653733008498	active sites [active]
653733008499	tetramer interface [polypeptide binding]; other site
653733008500	Response regulator receiver domain; Region: Response_reg; pfam00072
653733008501	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
653733008502	active site
653733008503	phosphorylation site [posttranslational modification]
653733008504	intermolecular recognition site; other site
653733008505	dimerization interface [polypeptide binding]; other site
653733008506	Response regulator receiver domain; Region: Response_reg; pfam00072
653733008507	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
653733008508	active site
653733008509	phosphorylation site [posttranslational modification]
653733008510	intermolecular recognition site; other site
653733008511	dimerization interface [polypeptide binding]; other site
653733008512	hypothetical protein; Provisional; Region: PRK13560
653733008513	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
653733008514	putative active site [active]
653733008515	heme pocket [chemical binding]; other site
653733008516	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
653733008517	putative active site [active]
653733008518	heme pocket [chemical binding]; other site
653733008519	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
653733008520	putative active site [active]
653733008521	heme pocket [chemical binding]; other site
653733008522	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
653733008523	putative active site [active]
653733008524	heme pocket [chemical binding]; other site
653733008525	Histidine kinase; Region: HisKA_2; pfam07568
653733008526	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
653733008527	ATP binding site [chemical binding]; other site
653733008528	Mg2+ binding site [ion binding]; other site
653733008529	G-X-G motif; other site
653733008530	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
653733008531	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
653733008532	dimer interface [polypeptide binding]; other site
653733008533	phosphorylation site [posttranslational modification]
653733008534	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
653733008535	ATP binding site [chemical binding]; other site
653733008536	Mg2+ binding site [ion binding]; other site
653733008537	G-X-G motif; other site
653733008538	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
653733008539	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
653733008540	active site
653733008541	phosphorylation site [posttranslational modification]
653733008542	intermolecular recognition site; other site
653733008543	dimerization interface [polypeptide binding]; other site
653733008544	PAS domain S-box; Region: sensory_box; TIGR00229
653733008545	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
653733008546	putative active site [active]
653733008547	heme pocket [chemical binding]; other site
653733008548	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
653733008549	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
653733008550	metal binding site [ion binding]; metal-binding site
653733008551	active site
653733008552	I-site; other site
653733008553	NOL1/NOP2/sun family; Region: Nol1_Nop2_Fmu; pfam01189
653733008554	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
653733008555	S-adenosylmethionine binding site [chemical binding]; other site
653733008556	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
653733008557	Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205
653733008558	active site
653733008559	nucleophile elbow; other site
653733008560	Surface antigen; Region: Bac_surface_Ag; pfam01103
653733008561	excinuclease ABC subunit B; Provisional; Region: PRK05298
653733008562	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
653733008563	ATP binding site [chemical binding]; other site
653733008564	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
653733008565	nucleotide binding region [chemical binding]; other site
653733008566	ATP-binding site [chemical binding]; other site
653733008567	Ultra-violet resistance protein B; Region: UvrB; pfam12344
653733008568	UvrB/uvrC motif; Region: UVR; pfam02151
653733008569	Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme; Region: NT_2-5OAS_ClassI-CCAase; cd05400
653733008570	active site
653733008571	NTP binding site [chemical binding]; other site
653733008572	metal binding triad [ion binding]; metal-binding site
653733008573	catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061
653733008574	Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196
653733008575	heme binding site [chemical binding]; other site
653733008576	C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200
653733008577	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
653733008578	metal binding site 2 [ion binding]; metal-binding site
653733008579	putative DNA binding helix; other site
653733008580	metal binding site 1 [ion binding]; metal-binding site
653733008581	dimer interface [polypeptide binding]; other site
653733008582	structural Zn2+ binding site [ion binding]; other site
653733008583	hypothetical protein; Provisional; Region: PRK08201
653733008584	Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680
653733008585	metal binding site [ion binding]; metal-binding site
653733008586	putative dimer interface [polypeptide binding]; other site
653733008587	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
653733008588	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
653733008589	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
653733008590	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
653733008591	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373
653733008592	AAA domain; Region: AAA_14; pfam13173
653733008593	IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339
653733008594	Putative addiction module component; Region: Unstab_antitox; pfam09720
653733008595	signal recognition particle protein; Provisional; Region: PRK10867
653733008596	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
653733008597	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
653733008598	P loop; other site
653733008599	GTP binding site [chemical binding]; other site
653733008600	Signal peptide binding domain; Region: SRP_SPB; pfam02978
653733008601	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
653733008602	Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837
653733008603	KH-II  (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins  (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cl00098
653733008604	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
653733008605	RimM N-terminal domain; Region: RimM; pfam01782
653733008606	PRC-barrel domain; Region: PRC; pfam05239
653733008607	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
653733008608	SAM-dependent RNA methyltransferase; Region: Methyltrn_RNA_4; pfam09936
653733008609	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
653733008610	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
653733008611	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
653733008612	DNA binding residues [nucleotide binding]
653733008613	Dinitrogenase iron-molybdenum cofactor; Region: Nitro_FeMo-Co; pfam02579
653733008614	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
653733008615	Protein of unknown function (DUF3108); Region: DUF3108; pfam11306
653733008616	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
653733008617	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113
653733008618	active site
653733008619	PHP Thumb interface [polypeptide binding]; other site
653733008620	metal binding site [ion binding]; metal-binding site
653733008621	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
653733008622	generic binding surface II; other site
653733008623	generic binding surface I; other site
653733008624	Protein of unknown function (DUF4236); Region: DUF4236; pfam14020
653733008625	PAS domain; Region: PAS; smart00091
653733008626	PAS domain; Region: PAS_9; pfam13426
653733008627	PAS domain; Region: PAS; smart00091
653733008628	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
653733008629	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
653733008630	dimer interface [polypeptide binding]; other site
653733008631	phosphorylation site [posttranslational modification]
653733008632	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
653733008633	ATP binding site [chemical binding]; other site
653733008634	Mg2+ binding site [ion binding]; other site
653733008635	G-X-G motif; other site
653733008636	Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776
653733008637	Chemotaxis phosphatase CheX; Region: CheX; cl15816
653733008638	Response regulator receiver domain; Region: Response_reg; pfam00072
653733008639	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
653733008640	active site
653733008641	phosphorylation site [posttranslational modification]
653733008642	intermolecular recognition site; other site
653733008643	dimerization interface [polypeptide binding]; other site
653733008644	PEP synthetase regulatory protein; Provisional; Region: PRK05339
653733008645	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
653733008646	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
653733008647	dimer interface [polypeptide binding]; other site
653733008648	phosphorylation site [posttranslational modification]
653733008649	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
653733008650	ATP binding site [chemical binding]; other site
653733008651	Mg2+ binding site [ion binding]; other site
653733008652	G-X-G motif; other site
653733008653	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
653733008654	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
653733008655	active site
653733008656	phosphorylation site [posttranslational modification]
653733008657	intermolecular recognition site; other site
653733008658	dimerization interface [polypeptide binding]; other site
653733008659	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
653733008660	DNA binding site [nucleotide binding]
653733008661	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
653733008662	PhoU domain; Region: PhoU; pfam01895
653733008663	PhoU domain; Region: PhoU; pfam01895
653733008664	transcriptional regulator PhoU; Provisional; Region: PRK11115
653733008665	PhoU domain; Region: PhoU; pfam01895
653733008666	PhoU domain; Region: PhoU; pfam01895
653733008667	phosphate transporter ATP-binding protein; Provisional; Region: PRK14236
653733008668	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
653733008669	Walker A/P-loop; other site
653733008670	ATP binding site [chemical binding]; other site
653733008671	Q-loop/lid; other site
653733008672	ABC transporter signature motif; other site
653733008673	Walker B; other site
653733008674	D-loop; other site
653733008675	H-loop/switch region; other site
653733008676	ABC-type phosphate transport system, auxiliary component [Inorganic ion transport and metabolism]; Region: COG4985
653733008677	phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974
653733008678	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
653733008679	dimer interface [polypeptide binding]; other site
653733008680	conserved gate region; other site
653733008681	putative PBP binding loops; other site
653733008682	ABC-ATPase subunit interface; other site
653733008683	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4590
653733008684	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
653733008685	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
653733008686	dimer interface [polypeptide binding]; other site
653733008687	conserved gate region; other site
653733008688	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
653733008689	dimer interface [polypeptide binding]; other site
653733008690	conserved gate region; other site
653733008691	putative PBP binding loops; other site
653733008692	ABC-ATPase subunit interface; other site
653733008693	PBP superfamily domain; Region: PBP_like_2; cl17296
653733008694	7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696
653733008695	7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695
653733008696	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
653733008697	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
653733008698	ATP binding site [chemical binding]; other site
653733008699	Mg2+ binding site [ion binding]; other site
653733008700	G-X-G motif; other site
653733008701	Protein of unknown function (DUF541); Region: SIMPL; pfam04402
653733008702	Fic/DOC family; Region: Fic; cl00960
653733008703	Predicted permease; Region: DUF318; cl17795
653733008704	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
653733008705	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
653733008706	active site residue [active]
653733008707	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
653733008708	active site residue [active]
653733008709	formate-dependent cytochrome c nitrite reductase, c552 subunit; Region: cyto_c552_HCOOH; TIGR03152
653733008710	cytochrome c nitrite reductase pentaheme subunit; Provisional; Region: PRK11659
653733008711	Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723
653733008712	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
653733008713	iron-sulfur cluster [ion binding]; other site
653733008714	[2Fe-2S] cluster binding site [ion binding]; other site
653733008715	Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290
653733008716	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
653733008717	heme bH binding site [chemical binding]; other site
653733008718	intrachain domain interface; other site
653733008719	Qi binding site; other site
653733008720	heme bL binding site [chemical binding]; other site
653733008721	interchain domain interface [polypeptide binding]; other site
653733008722	Qo binding site; other site
653733008723	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: PspE; COG0607
653733008724	active site residue [active]
653733008725	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
653733008726	active site residue [active]
653733008727	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
653733008728	active site residue [active]
653733008729	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
653733008730	active site residue [active]
653733008731	DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951
653733008732	thiosulfate reductase PhsA; Provisional; Region: PRK15488
653733008733	The MopB_Thiosulfate-R-like CD contains thiosulfate-, sulfur-, and polysulfide-reductases, and other related proteins. Thiosulfate reductase catalyzes the cleavage of sulfur-sulfur bonds in thiosulfate. Polysulfide reductase is a membrane-bound enzyme...; Region: MopB_Thiosulfate-R-like; cd02755
653733008734	putative [Fe4-S4] binding site [ion binding]; other site
653733008735	putative molybdopterin cofactor binding site [chemical binding]; other site
653733008736	The MopB_CT_Thiosulfate-R-like CD contains thiosulfate-, sulfur-, and polysulfide-reductases, and other related proteins. Thiosulfate reductase catalyzes the cleavage of sulfur-sulfur bonds in thiosulfate. Polysulfide reductase is a membrane-bound enzyme...; Region: MopB_CT_Thiosulfate-R-like; cd02778
653733008737	putative molybdopterin cofactor binding site; other site
653733008738	Nitrate reductase delta subunit; Region: Nitrate_red_del; pfam02613
653733008739	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
653733008740	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
653733008741	dimer interface [polypeptide binding]; other site
653733008742	putative CheW interface [polypeptide binding]; other site
653733008743	Hemerythrin; Region: Hemerythrin; cd12107
653733008744	Fe binding site [ion binding]; other site
653733008745	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
653733008746	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
653733008747	dimer interface [polypeptide binding]; other site
653733008748	putative CheW interface [polypeptide binding]; other site
653733008749	Hemerythrin; Region: Hemerythrin; cd12107
653733008750	Fe binding site [ion binding]; other site
653733008751	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
653733008752	trimer interface [polypeptide binding]; other site
653733008753	active site
653733008754	Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540
653733008755	active site
653733008756	DNA binding site [nucleotide binding]
653733008757	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
653733008758	hypothetical protein; Reviewed; Region: PRK12497
653733008759	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
653733008760	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
653733008761	putative active site [active]
653733008762	heme pocket [chemical binding]; other site
653733008763	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
653733008764	dimer interface [polypeptide binding]; other site
653733008765	phosphorylation site [posttranslational modification]
653733008766	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
653733008767	ATP binding site [chemical binding]; other site
653733008768	G-X-G motif; other site
653733008769	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
653733008770	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
653733008771	TPR motif; other site
653733008772	binding surface
653733008773	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
653733008774	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
653733008775	binding surface
653733008776	TPR motif; other site