-- dump date   	20140619_065224
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
246195000001	chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362
246195000002	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
246195000003	Walker A motif; other site
246195000004	ATP binding site [chemical binding]; other site
246195000005	Walker B motif; other site
246195000006	arginine finger; other site
246195000007	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
246195000008	DnaA box-binding interface [nucleotide binding]; other site
246195000009	DNA polymerase III subunit beta; Validated; Region: PRK05643
246195000010	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
246195000011	putative DNA binding surface [nucleotide binding]; other site
246195000012	dimer interface [polypeptide binding]; other site
246195000013	beta-clamp/clamp loader binding surface; other site
246195000014	beta-clamp/translesion DNA polymerase binding surface; other site
246195000015	acylglycerophosphoethanolamine acyltransferase; Provisional; Region: PRK06814
246195000016	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
246195000017	putative acyl-acceptor binding pocket; other site
246195000018	glutamate racemase; Provisional; Region: PRK00865
246195000019	TIGR01666 family membrane protein; Region: YCCS
246195000020	FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805
246195000021	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
246195000022	Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886
246195000023	Leucine rich repeat; Region: LRR_8; pfam13855
246195000024	putative transporter; Validated; Region: PRK03818
246195000025	Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826
246195000026	TrkA-C domain; Region: TrkA_C; pfam02080
246195000027	TrkA-C domain; Region: TrkA_C; pfam02080
246195000028	Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826
246195000029	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
246195000030	Ligand Binding Site [chemical binding]; other site
246195000031	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
246195000032	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
246195000033	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
246195000034	Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893
246195000035	M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890
246195000036	metal binding site [ion binding]; metal-binding site
246195000037	dimer interface [polypeptide binding]; other site
246195000038	ornithine decarboxylase; Provisional; Region: PRK13578
246195000039	Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709
246195000040	Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615
246195000041	homodimer interface [polypeptide binding]; other site
246195000042	pyridoxal 5'-phosphate binding site [chemical binding]; other site
246195000043	catalytic residue [active]
246195000044	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
246195000045	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
246195000046	putrescine transporter; Provisional; Region: potE; PRK10655
246195000047	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884
246195000048	tRNA threonylcarbamoyl adenosine modification protein YgjD; Region: T6A_YgjD; TIGR03723
246195000049	HD domain; Region: HD_4; pfam13328
246195000050	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
246195000051	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
246195000052	synthetase active site [active]
246195000053	NTP binding site [chemical binding]; other site
246195000054	metal binding site [ion binding]; metal-binding site
246195000055	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
246195000056	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
246195000057	aminopeptidase N; Provisional; Region: pepN; PRK14015
246195000058	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
246195000059	Zn binding site [ion binding]; other site
246195000060	bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232
246195000061	Malic enzyme, N-terminal domain; Region: malic; pfam00390
246195000062	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
246195000063	putative NAD(P) binding site [chemical binding]; other site
246195000064	Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280
246195000065	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
246195000066	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
246195000067	DsrE/DsrF/DrsH-like family; Region: DrsE_2; cl17453
246195000068	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
246195000069	active site
246195000070	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
246195000071	TPR repeat; Region: TPR_11; pfam13414
246195000072	TPR motif; other site
246195000073	binding surface
246195000074	Protein of unknown function (DUF560); Region: DUF560; pfam04575
246195000075	Queuosine biosynthesis protein; Region: Queuosine_synth; pfam02547
246195000076	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
246195000077	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033
246195000078	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
246195000079	RNA binding site [nucleotide binding]; other site
246195000080	active site
246195000081	Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157
246195000082	Ribosome-binding factor A; Region: RBFA; pfam02033
246195000083	translation initiation factor IF-2; Region: IF-2; TIGR00487
246195000084	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
246195000085	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
246195000086	G1 box; other site
246195000087	putative GEF interaction site [polypeptide binding]; other site
246195000088	GTP/Mg2+ binding site [chemical binding]; other site
246195000089	Switch I region; other site
246195000090	G2 box; other site
246195000091	G3 box; other site
246195000092	Switch II region; other site
246195000093	G4 box; other site
246195000094	G5 box; other site
246195000095	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
246195000096	Translation-initiation factor 2; Region: IF-2; pfam11987
246195000097	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
246195000098	transcription elongation factor NusA; Validated; Region: nusA; PRK09202
246195000099	NusA N-terminal domain; Region: NusA_N; pfam08529
246195000100	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
246195000101	RNA binding site [nucleotide binding]; other site
246195000102	homodimer interface [polypeptide binding]; other site
246195000103	NusA-like KH domain; Region: KH_5; pfam13184
246195000104	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
246195000105	G-X-X-G motif; other site
246195000106	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
246195000107	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
246195000108	ribosome maturation protein RimP; Reviewed; Region: PRK00092
246195000109	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
246195000110	putative oligomer interface [polypeptide binding]; other site
246195000111	putative RNA binding site [nucleotide binding]; other site
246195000112	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
246195000113	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
246195000114	substrate binding pocket [chemical binding]; other site
246195000115	membrane-bound complex binding site; other site
246195000116	hinge residues; other site
246195000117	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
246195000118	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
246195000119	substrate binding pocket [chemical binding]; other site
246195000120	membrane-bound complex binding site; other site
246195000121	hinge residues; other site
246195000122	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
246195000123	putative active site [active]
246195000124	Bacterial SH3 domain; Region: SH3_4; pfam06347
246195000125	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
246195000126	NlpC/P60 family; Region: NLPC_P60; pfam00877
246195000127	DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14950
246195000128	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
246195000129	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
246195000130	Protein export membrane protein; Region: SecD_SecF; pfam02355
246195000131	SecD export protein N-terminal TM region; Region: SecD-TM1; cl08136
246195000132	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
246195000133	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
246195000134	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
246195000135	preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585
246195000136	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
246195000137	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
246195000138	active site
246195000139	DNA binding site [nucleotide binding]
246195000140	Int/Topo IB signature motif; other site
246195000141	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
246195000142	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
246195000143	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
246195000144	Uncharacterized conserved protein [Function unknown]; Region: COG1739
246195000145	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
246195000146	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
246195000147	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
246195000148	Walker A/P-loop; other site
246195000149	ATP binding site [chemical binding]; other site
246195000150	Q-loop/lid; other site
246195000151	ABC transporter signature motif; other site
246195000152	Walker B; other site
246195000153	D-loop; other site
246195000154	H-loop/switch region; other site
246195000155	putative inner membrane peptidase; Provisional; Region: PRK11778
246195000156	Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496
246195000157	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
246195000158	tandem repeat interface [polypeptide binding]; other site
246195000159	oligomer interface [polypeptide binding]; other site
246195000160	active site residues [active]
246195000161	Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893
246195000162	M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890
246195000163	metal binding site [ion binding]; metal-binding site
246195000164	dimer interface [polypeptide binding]; other site
246195000165	Predicted membrane protein [Function unknown]; Region: COG2860
246195000166	UPF0126 domain; Region: UPF0126; pfam03458
246195000167	UPF0126 domain; Region: UPF0126; pfam03458
246195000168	putative mechanosensitive channel protein; Provisional; Region: PRK11465
246195000169	Mechanosensitive ion channel; Region: MS_channel; pfam00924
246195000170	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
246195000171	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
246195000172	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
246195000173	multidrug resistance protein MdtH; Provisional; Region: PRK11646
246195000174	putative substrate translocation pore; other site
246195000175	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
246195000176	putative active site [active]
246195000177	catalytic residue [active]
246195000178	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
246195000179	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
246195000180	5S rRNA interface [nucleotide binding]; other site
246195000181	CTC domain interface [polypeptide binding]; other site
246195000182	L16 interface [polypeptide binding]; other site
246195000183	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
246195000184	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
246195000185	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
246195000186	active site
246195000187	outer membrane lipoprotein LolB; Provisional; Region: lolB; PRK00022
246195000188	Outer membrane lipoprotein LolB; Region: LolB; pfam03550
246195000189	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
246195000190	TPR motif; other site
246195000191	binding surface
246195000192	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
246195000193	binding surface
246195000194	TPR motif; other site
246195000195	TPR repeat; Region: TPR_11; pfam13414
246195000196	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
246195000197	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
246195000198	tRNA; other site
246195000199	putative tRNA binding site [nucleotide binding]; other site
246195000200	putative NADP binding site [chemical binding]; other site
246195000201	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
246195000202	peptide chain release factor 1; Validated; Region: prfA; PRK00591
246195000203	This domain is found in peptide chain release factors; Region: PCRF; smart00937
246195000204	RF-1 domain; Region: RF-1; pfam00472
246195000205	protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534
246195000206	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
246195000207	S-adenosylmethionine binding site [chemical binding]; other site
246195000208	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
246195000209	Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355
246195000210	active site
246195000211	Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623
246195000212	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
246195000213	NAD binding site [chemical binding]; other site
246195000214	homotetramer interface [polypeptide binding]; other site
246195000215	homodimer interface [polypeptide binding]; other site
246195000216	substrate binding site [chemical binding]; other site
246195000217	active site
246195000218	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
246195000219	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
246195000220	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
246195000221	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
246195000222	ABC transporter signature motif; other site
246195000223	Walker B; other site
246195000224	D-loop; other site
246195000225	H-loop/switch region; other site
246195000226	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
246195000227	AIR carboxylase; Region: AIRC; pfam00731
246195000228	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
246195000229	ATP-grasp domain; Region: ATP-grasp; pfam02222
246195000230	tRNA pseudouridine synthase C; Region: DUF446; pfam04287
246195000231	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
246195000232	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
246195000233	ligand binding site [chemical binding]; other site
246195000234	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
246195000235	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
246195000236	active site
246195000237	Riboflavin kinase; Region: Flavokinase; pfam01687
246195000238	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
246195000239	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
246195000240	active site
246195000241	HIGH motif; other site
246195000242	nucleotide binding site [chemical binding]; other site
246195000243	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
246195000244	active site
246195000245	KMSKS motif; other site
246195000246	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
246195000247	tRNA binding surface [nucleotide binding]; other site
246195000248	anticodon binding site; other site
246195000249	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
246195000250	lipoprotein signal peptidase; Provisional; Region: PRK14787
246195000251	lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376
246195000252	glutathionine S-transferase; Provisional; Region: PRK10542
246195000253	GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057
246195000254	C-terminal domain interface [polypeptide binding]; other site
246195000255	GSH binding site (G-site) [chemical binding]; other site
246195000256	dimer interface [polypeptide binding]; other site
246195000257	C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188
246195000258	dimer interface [polypeptide binding]; other site
246195000259	substrate binding pocket (H-site) [chemical binding]; other site
246195000260	N-terminal domain interface [polypeptide binding]; other site
246195000261	coproporphyrinogen III oxidase; Provisional; Region: PRK09249
246195000262	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
246195000263	FeS/SAM binding site; other site
246195000264	HemN C-terminal domain; Region: HemN_C; pfam06969
246195000265	amidophosphoribosyltransferase; Provisional; Region: PRK09246
246195000266	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
246195000267	active site
246195000268	tetramer interface [polypeptide binding]; other site
246195000269	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
246195000270	active site
246195000271	Putative SAM-dependent methyltransferase; Region: SAM_MT; cl17517
246195000272	Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564
246195000273	Thiamine pyrophosphokinase; Region: TPK; cd07995
246195000274	active site
246195000275	dimerization interface [polypeptide binding]; other site
246195000276	thiamine binding site [chemical binding]; other site
246195000277	Predicted flavoprotein [General function prediction only]; Region: COG0431
246195000278	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
246195000279	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
246195000280	glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534
246195000281	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
246195000282	lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203
246195000283	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
246195000284	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
246195000285	Walker A/P-loop; other site
246195000286	ATP binding site [chemical binding]; other site
246195000287	Q-loop/lid; other site
246195000288	ABC transporter signature motif; other site
246195000289	Walker B; other site
246195000290	D-loop; other site
246195000291	H-loop/switch region; other site
246195000292	bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316
246195000293	RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172
246195000294	putative ribose interaction site [chemical binding]; other site
246195000295	putative ADP binding site [chemical binding]; other site
246195000296	rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199
246195000297	active site
246195000298	nucleotide binding site [chemical binding]; other site
246195000299	HIGH motif; other site
246195000300	KMSKS motif; other site
246195000301	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
246195000302	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
246195000303	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
246195000304	active site
246195000305	Tetratricopeptide repeat; Region: TPR_12; pfam13424
246195000306	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
246195000307	binding surface
246195000308	TPR motif; other site
246195000309	Membrane bound YbgT-like protein; Region: YbgT_YccB; pfam08173
246195000310	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
246195000311	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
246195000312	cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097
246195000313	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562
246195000314	thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868
246195000315	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
246195000316	Walker A/P-loop; other site
246195000317	ATP binding site [chemical binding]; other site
246195000318	Q-loop/lid; other site
246195000319	ABC transporter signature motif; other site
246195000320	Walker B; other site
246195000321	D-loop; other site
246195000322	H-loop/switch region; other site
246195000323	thiol reductant ABC exporter, CydD subunit; Region: CydD; TIGR02857
246195000324	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
246195000325	Walker A/P-loop; other site
246195000326	ATP binding site [chemical binding]; other site
246195000327	Q-loop/lid; other site
246195000328	ABC transporter signature motif; other site
246195000329	Walker B; other site
246195000330	D-loop; other site
246195000331	H-loop/switch region; other site
246195000332	Cupin domain; Region: Cupin_2; cl17218
246195000333	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
246195000334	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
246195000335	Sulfate transporter family; Region: Sulfate_transp; pfam00916
246195000336	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837
246195000337	active site
246195000338	dimer interface [polypeptide binding]; other site
246195000339	L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681
246195000340	Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814
246195000341	threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672
246195000342	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
246195000343	Clp amino terminal domain; Region: Clp_N; pfam02861
246195000344	Clp amino terminal domain; Region: Clp_N; pfam02861
246195000345	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
246195000346	Walker A motif; other site
246195000347	ATP binding site [chemical binding]; other site
246195000348	Walker B motif; other site
246195000349	arginine finger; other site
246195000350	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
246195000351	Walker A motif; other site
246195000352	ATP binding site [chemical binding]; other site
246195000353	Walker B motif; other site
246195000354	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
246195000355	Tfp pilus assembly protein, major pilin PilA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilA; COG4969
246195000356	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
246195000357	Pilin (bacterial filament); Region: Pilin; pfam00114
246195000358	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
246195000359	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
246195000360	hinge; other site
246195000361	active site
246195000362	cytidylate kinase; Provisional; Region: cmk; PRK00023
246195000363	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
246195000364	CMP-binding site; other site
246195000365	The sites determining sugar specificity; other site
246195000366	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299
246195000367	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
246195000368	RNA binding site [nucleotide binding]; other site
246195000369	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
246195000370	RNA binding site [nucleotide binding]; other site
246195000371	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
246195000372	RNA binding site [nucleotide binding]; other site
246195000373	S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689
246195000374	RNA binding site [nucleotide binding]; other site
246195000375	S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690
246195000376	RNA binding site [nucleotide binding]; other site
246195000377	S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691
246195000378	RNA binding site [nucleotide binding]; other site
246195000379	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
246195000380	IHF dimer interface [polypeptide binding]; other site
246195000381	IHF - DNA interface [nucleotide binding]; other site
246195000382	Staphylococcal nuclease homologues; Region: SNc; smart00318
246195000383	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140
246195000384	Catalytic site; other site
246195000385	poly(A) polymerase; Region: pcnB; TIGR01942
246195000386	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
246195000387	active site
246195000388	NTP binding site [chemical binding]; other site
246195000389	metal binding triad [ion binding]; metal-binding site
246195000390	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
246195000391	Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626
246195000392	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
246195000393	catalytic center binding site [active]
246195000394	ATP binding site [chemical binding]; other site
246195000395	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
246195000396	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
246195000397	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
246195000398	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
246195000399	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
246195000400	dimerization domain swap beta strand [polypeptide binding]; other site
246195000401	regulatory protein interface [polypeptide binding]; other site
246195000402	active site
246195000403	regulatory phosphorylation site [posttranslational modification]; other site
246195000404	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
246195000405	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
246195000406	active site
246195000407	motif I; other site
246195000408	motif II; other site
246195000409	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
246195000410	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
246195000411	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
246195000412	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
246195000413	Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429
246195000414	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
246195000415	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
246195000416	dimer interface [polypeptide binding]; other site
246195000417	ssDNA binding site [nucleotide binding]; other site
246195000418	tetramer (dimer of dimers) interface [polypeptide binding]; other site
246195000419	TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358
246195000420	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
246195000421	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034
246195000422	D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429
246195000423	Protein of unknown function (DUF615); Region: DUF615; pfam04751
246195000424	HemN family oxidoreductase; Provisional; Region: PRK05660
246195000425	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
246195000426	FeS/SAM binding site; other site
246195000427	HemN C-terminal domain; Region: HemN_C; pfam06969
246195000428	Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966
246195000429	Carbon starvation protein CstA; Region: CstA; pfam02554
246195000430	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
246195000431	aromatic amino acid exporter; Provisional; Region: PRK11689
246195000432	Domain of unknown function (DUF4198); Region: DUF4198; pfam10670
246195000433	FeoA domain; Region: FeoA; pfam04023
246195000434	Ferrous iron transport protein B; Region: FeoB_N; pfam02421
246195000435	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
246195000436	G1 box; other site
246195000437	GTP/Mg2+ binding site [chemical binding]; other site
246195000438	Switch I region; other site
246195000439	G2 box; other site
246195000440	G3 box; other site
246195000441	Switch II region; other site
246195000442	G4 box; other site
246195000443	G5 box; other site
246195000444	Nucleoside recognition; Region: Gate; pfam07670
246195000445	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
246195000446	Nucleoside recognition; Region: Gate; pfam07670
246195000447	bifunctional nicotinamide mononucleotide adenylyltransferase/ADP-ribose pyrophosphatase; Provisional; Region: PRK05379
246195000448	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
246195000449	active site
246195000450	nucleotide binding site [chemical binding]; other site
246195000451	HIGH motif; other site
246195000452	KMSKS motif; other site
246195000453	ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051
246195000454	nudix motif; other site
246195000455	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
246195000456	Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
246195000457	POT family; Region: PTR2; cl17359
246195000458	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
246195000459	Domain of unknown function DUF21; Region: DUF21; pfam01595
246195000460	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
246195000461	Transporter associated domain; Region: CorC_HlyC; smart01091
246195000462	DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151
246195000463	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
246195000464	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
246195000465	dimerization interface [polypeptide binding]; other site
246195000466	peroxiredoxin; Region: AhpC; TIGR03137
246195000467	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
246195000468	dimer interface [polypeptide binding]; other site
246195000469	decamer (pentamer of dimers) interface [polypeptide binding]; other site
246195000470	catalytic triad [active]
246195000471	peroxidatic and resolving cysteines [active]
246195000472	alkyl hydroperoxide reductase subunit F; Region: AhpF; TIGR03140
246195000473	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
246195000474	TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026
246195000475	catalytic residues [active]
246195000476	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
246195000477	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
246195000478	Roadblock/LC7 domain; Region: Robl_LC7; smart00960
246195000479	GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100
246195000480	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
246195000481	G1 box; other site
246195000482	GTP/Mg2+ binding site [chemical binding]; other site
246195000483	G2 box; other site
246195000484	Switch I region; other site
246195000485	G3 box; other site
246195000486	Switch II region; other site
246195000487	G4 box; other site
246195000488	G5 box; other site
246195000489	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
246195000490	PGAP1-like protein; Region: PGAP1; pfam07819
246195000491	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
246195000492	MarR family; Region: MarR; pfam01047
246195000493	DNA topoisomerase I; Provisional; Region: PRK08780
246195000494	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
246195000495	active site
246195000496	interdomain interaction site; other site
246195000497	putative metal-binding site [ion binding]; other site
246195000498	nucleotide binding site [chemical binding]; other site
246195000499	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
246195000500	domain I; other site
246195000501	DNA binding groove [nucleotide binding]
246195000502	phosphate binding site [ion binding]; other site
246195000503	domain II; other site
246195000504	domain III; other site
246195000505	nucleotide binding site [chemical binding]; other site
246195000506	catalytic site [active]
246195000507	domain IV; other site
246195000508	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
246195000509	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
246195000510	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
246195000511	Protein of unknown function (DUF494); Region: DUF494; pfam04361
246195000512	Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758
246195000513	DNA protecting protein DprA; Region: dprA; TIGR00732
246195000514	Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652
246195000515	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
246195000516	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
246195000517	active site
246195000518	catalytic residues [active]
246195000519	metal binding site [ion binding]; metal-binding site
246195000520	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
246195000521	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
246195000522	putative active site [active]
246195000523	substrate binding site [chemical binding]; other site
246195000524	putative cosubstrate binding site; other site
246195000525	catalytic site [active]
246195000526	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
246195000527	substrate binding site [chemical binding]; other site
246195000528	16S rRNA methyltransferase B; Provisional; Region: PRK10901
246195000529	NusB family; Region: NusB; pfam01029
246195000530	putative RNA binding site [nucleotide binding]; other site
246195000531	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
246195000532	S-adenosylmethionine binding site [chemical binding]; other site
246195000533	Domain of unknown function (DUF4390); Region: DUF4390; pfam14334
246195000534	Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000
246195000535	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
246195000536	dimerization interface [polypeptide binding]; other site
246195000537	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
246195000538	dimer interface [polypeptide binding]; other site
246195000539	phosphorylation site [posttranslational modification]
246195000540	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
246195000541	ATP binding site [chemical binding]; other site
246195000542	Mg2+ binding site [ion binding]; other site
246195000543	G-X-G motif; other site
246195000544	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
246195000545	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
246195000546	active site
246195000547	phosphorylation site [posttranslational modification]
246195000548	intermolecular recognition site; other site
246195000549	dimerization interface [polypeptide binding]; other site
246195000550	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
246195000551	Walker A motif; other site
246195000552	ATP binding site [chemical binding]; other site
246195000553	Walker B motif; other site
246195000554	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
246195000555	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
246195000556	DNA-binding site [nucleotide binding]; DNA binding site
246195000557	RNA-binding motif; other site
246195000558	Protein of unknown function (DUF1294); Region: DUF1294; pfam06961
246195000559	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
246195000560	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
246195000561	active site
246195000562	dimer interface [polypeptide binding]; other site
246195000563	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
246195000564	dimer interface [polypeptide binding]; other site
246195000565	active site
246195000566	DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773
246195000567	AAA domain; Region: AAA_30; pfam13604
246195000568	Family description; Region: UvrD_C_2; pfam13538
246195000569	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
246195000570	Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946
246195000571	active site
246195000572	intersubunit interface [polypeptide binding]; other site
246195000573	zinc binding site [ion binding]; other site
246195000574	Na+ binding site [ion binding]; other site
246195000575	CRISPR/Cas system-associated protein Csy1; Region: Csy1_I-F; cd09675
246195000576	CRISPR/Cas system-associated RAMP superfamily protein Csy2; Region: Csy2_I-F; cd09676
246195000577	CRISPR/Cas system-associated RAMP superfamily protein Csy3; Region: Csy3_I-F; cd09737
246195000578	CRISPR/Cas system-associated RAMP superfamily protein Cas6f; Region: Cas6_I-F; cd09674
246195000579	Phage terminase large subunit; Region: Terminase_3; cl12054
246195000580	Protein of unknown function (DUF935); Region: DUF935; pfam06074
246195000581	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
246195000582	ATP binding site [chemical binding]; other site
246195000583	putative Mg++ binding site [ion binding]; other site
246195000584	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
246195000585	nucleotide binding region [chemical binding]; other site
246195000586	ATP-binding site [chemical binding]; other site
246195000587	Domain of unknown function (DUF1837); Region: DUF1837; pfam08878
246195000588	Cyanobacterial and plastid NDH-1 subunit M; Region: NdhM; pfam10664
246195000589	PglZ domain; Region: PglZ; pfam08665
246195000590	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
246195000591	ATP binding site [chemical binding]; other site
246195000592	putative Mg++ binding site [ion binding]; other site
246195000593	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
246195000594	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
246195000595	nucleotide binding region [chemical binding]; other site
246195000596	ATP-binding site [chemical binding]; other site
246195000597	DNA methylase; Region: N6_N4_Mtase; cl17433
246195000598	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
246195000599	Walker A motif; other site
246195000600	ATP binding site [chemical binding]; other site
246195000601	Walker B motif; other site
246195000602	DNA binding domain, excisionase family; Region: excise; TIGR01764
246195000603	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
246195000604	putative active site pocket [active]
246195000605	dimerization interface [polypeptide binding]; other site
246195000606	putative catalytic residue [active]
246195000607	Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cd00352
246195000608	active site
246195000609	Glutamine amidotransferase domain; Region: GATase_6; pfam13522
246195000610	Putative amidoligase enzyme; Region: Amidoligase_2; pfam12224
246195000611	similar to hypothetical protein VrlB; identified by Glimmer2; putative
246195000612	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
246195000613	Uncharacterized conserved protein [Function unknown]; Region: COG2013
246195000614	nicotinate phosphoribosyltransferase; Validated; Region: PRK09243
246195000615	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570
246195000616	active site
246195000617	NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171
246195000618	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
246195000619	homodimer interface [polypeptide binding]; other site
246195000620	NAD binding pocket [chemical binding]; other site
246195000621	ATP binding pocket [chemical binding]; other site
246195000622	Mg binding site [ion binding]; other site
246195000623	active-site loop [active]
246195000624	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
246195000625	dimer interface [polypeptide binding]; other site
246195000626	substrate binding site [chemical binding]; other site
246195000627	metal binding sites [ion binding]; metal-binding site
246195000628	Putative p-aminobenzoyl-glutamate transporter [Coenzyme metabolism]; Region: AbgT; COG2978
246195000629	p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819
246195000630	Di- and tripeptidases [Amino acid transport and metabolism]; Region: PepD; COG2195
246195000631	M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892
246195000632	metal binding site [ion binding]; metal-binding site
246195000633	dimer interface [polypeptide binding]; other site
246195000634	recombination protein F; Reviewed; Region: recF; PRK00064
246195000635	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
246195000636	Walker A/P-loop; other site
246195000637	ATP binding site [chemical binding]; other site
246195000638	Q-loop/lid; other site
246195000639	ABC transporter signature motif; other site
246195000640	Walker B; other site
246195000641	D-loop; other site
246195000642	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
246195000643	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
246195000644	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
246195000645	Walker A motif; other site
246195000646	ATP binding site [chemical binding]; other site
246195000647	Walker B motif; other site
246195000648	arginine finger; other site
246195000649	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
246195000650	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
246195000651	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
246195000652	catalytic residue [active]
246195000653	FxsA cytoplasmic membrane protein; Region: FxsA; pfam04186
246195000654	DNA polymerase I; Provisional; Region: PRK05755
246195000655	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
246195000656	active site
246195000657	metal binding site 1 [ion binding]; metal-binding site
246195000658	putative 5' ssDNA interaction site; other site
246195000659	metal binding site 3; metal-binding site
246195000660	metal binding site 2 [ion binding]; metal-binding site
246195000661	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
246195000662	putative DNA binding site [nucleotide binding]; other site
246195000663	putative metal binding site [ion binding]; other site
246195000664	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
246195000665	active site
246195000666	catalytic site [active]
246195000667	substrate binding site [chemical binding]; other site
246195000668	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
246195000669	active site
246195000670	DNA binding site [nucleotide binding]
246195000671	catalytic site [active]
246195000672	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
246195000673	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
246195000674	active site
246195000675	substrate binding site [chemical binding]; other site
246195000676	cosubstrate binding site; other site
246195000677	catalytic site [active]
246195000678	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
246195000679	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
246195000680	active site
246195000681	HIGH motif; other site
246195000682	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
246195000683	KMSKS motif; other site
246195000684	Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963
246195000685	tRNA binding surface [nucleotide binding]; other site
246195000686	anticodon binding site; other site
246195000687	cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920
246195000688	substrate binding site [chemical binding]; other site
246195000689	cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920
246195000690	substrate binding site [chemical binding]; other site
246195000691	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
246195000692	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
246195000693	putative active site [active]
246195000694	putative metal binding site [ion binding]; other site
246195000695	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
246195000696	glycerol kinase; Provisional; Region: glpK; PRK00047
246195000697	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
246195000698	N- and C-terminal domain interface [polypeptide binding]; other site
246195000699	active site
246195000700	MgATP binding site [chemical binding]; other site
246195000701	catalytic site [active]
246195000702	metal binding site [ion binding]; metal-binding site
246195000703	glycerol binding site [chemical binding]; other site
246195000704	homotetramer interface [polypeptide binding]; other site
246195000705	homodimer interface [polypeptide binding]; other site
246195000706	FBP binding site [chemical binding]; other site
246195000707	protein IIAGlc interface [polypeptide binding]; other site
246195000708	Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580
246195000709	amphipathic channel; other site
246195000710	Asn-Pro-Ala signature motifs; other site
246195000711	similar to hypothetical protein; identified by Glimmer2; putative
246195000712	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2958
246195000713	Protein of unknown function DUF45; Region: DUF45; pfam01863
246195000714	type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348
246195000715	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
246195000716	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
246195000717	ATP binding site [chemical binding]; other site
246195000718	putative Mg++ binding site [ion binding]; other site
246195000719	Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme; Region: NT_2-5OAS_ClassI-CCAase; cd05400
246195000720	active site
246195000721	NTP binding site [chemical binding]; other site
246195000722	metal binding triad [ion binding]; metal-binding site
246195000723	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
246195000724	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
246195000725	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
246195000726	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
246195000727	HsdM N-terminal domain; Region: HsdM_N; pfam12161
246195000728	Methyltransferase domain; Region: Methyltransf_26; pfam13659
246195000729	Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496
246195000730	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
246195000731	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
246195000732	putative acyl-acceptor binding pocket; other site
246195000733	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
246195000734	IHF dimer interface [polypeptide binding]; other site
246195000735	IHF - DNA interface [nucleotide binding]; other site
246195000736	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
246195000737	Found in ATP-dependent protease La (LON); Region: LON; smart00464
246195000738	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
246195000739	Walker A motif; other site
246195000740	ATP binding site [chemical binding]; other site
246195000741	Walker B motif; other site
246195000742	arginine finger; other site
246195000743	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
246195000744	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
246195000745	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
246195000746	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
246195000747	Walker A motif; other site
246195000748	ATP binding site [chemical binding]; other site
246195000749	Walker B motif; other site
246195000750	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
246195000751	Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740
246195000752	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
246195000753	oligomer interface [polypeptide binding]; other site
246195000754	active site residues [active]
246195000755	trigger factor; Provisional; Region: tig; PRK01490
246195000756	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
246195000757	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
246195000758	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
246195000759	active site
246195000760	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
246195000761	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
246195000762	active site
246195000763	HIGH motif; other site
246195000764	dimer interface [polypeptide binding]; other site
246195000765	KMSKS motif; other site
246195000766	Telomere recombination; Region: Sua5_yciO_yrdC; cl00305
246195000767	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
246195000768	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
246195000769	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
246195000770	FMN binding site [chemical binding]; other site
246195000771	substrate binding site [chemical binding]; other site
246195000772	putative catalytic residue [active]
246195000773	Uncharacterized conserved protein [Function unknown]; Region: COG4121
246195000774	bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747
246195000775	Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339
246195000776	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
246195000777	active site
246195000778	Zn binding site [ion binding]; other site
246195000779	Lecithin retinol acyltransferase; Region: LRAT; pfam04970
246195000780	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574
246195000781	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
246195000782	Lipopolysaccharide-assembly; Region: LptE; cl01125
246195000783	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
246195000784	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
246195000785	HIGH motif; other site
246195000786	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
246195000787	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
246195000788	active site
246195000789	KMSKS motif; other site
246195000790	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
246195000791	tRNA binding surface [nucleotide binding]; other site
246195000792	apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302
246195000793	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
246195000794	putative active site [active]
246195000795	catalytic triad [active]
246195000796	putative dimer interface [polypeptide binding]; other site
246195000797	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
246195000798	TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358
246195000799	Microscilla MS158 and related proteins, metallophosphatase domain; Region: MPP_MS158; cd07404
246195000800	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
246195000801	putative active site [active]
246195000802	putative metal binding site [ion binding]; other site
246195000803	Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; pfam04257
246195000804	exonuclease V subunit gamma; Provisional; Region: recC; PRK11069
246195000805	exonuclease V subunit gamma; Provisional; Region: recC; PRK11069
246195000806	glucans biosynthesis protein; Provisional; Region: opgC; PRK03854
246195000807	Acyltransferase family; Region: Acyl_transf_3; pfam01757
246195000808	Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961
246195000809	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01096
246195000810	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; smart00471
246195000811	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
246195000812	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
246195000813	NMT1/THI5 like; Region: NMT1; pfam09084
246195000814	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
246195000815	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
246195000816	dimer interface [polypeptide binding]; other site
246195000817	conserved gate region; other site
246195000818	putative PBP binding loops; other site
246195000819	ABC-ATPase subunit interface; other site
246195000820	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
246195000821	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
246195000822	Walker A/P-loop; other site
246195000823	ATP binding site [chemical binding]; other site
246195000824	Q-loop/lid; other site
246195000825	ABC transporter signature motif; other site
246195000826	Walker B; other site
246195000827	D-loop; other site
246195000828	H-loop/switch region; other site
246195000829	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
246195000830	Protein of unknown function (DUF4065); Region: DUF4065; pfam13274
246195000831	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
246195000832	non-specific DNA binding site [nucleotide binding]; other site
246195000833	Predicted transcriptional regulator [Transcription]; Region: COG2932
246195000834	salt bridge; other site
246195000835	sequence-specific DNA binding site [nucleotide binding]; other site
246195000836	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
246195000837	Catalytic site [active]
246195000838	Uncharacterized virulence-associated protein D [Function unknown]; Region: VapD; COG3309
246195000839	Predicted P-loop ATPase and inactivated derivatives [General function prediction only]; Region: COG5545
246195000840	Virulence-associated protein E; Region: VirE; pfam05272
246195000841	Predicted transcriptional regulator [Transcription]; Region: COG3636; cl17681
246195000842	Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093
246195000843	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
246195000844	non-specific DNA binding site [nucleotide binding]; other site
246195000845	salt bridge; other site
246195000846	sequence-specific DNA binding site [nucleotide binding]; other site
246195000847	Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093
246195000848	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
246195000849	non-specific DNA binding site [nucleotide binding]; other site
246195000850	salt bridge; other site
246195000851	sequence-specific DNA binding site [nucleotide binding]; other site
246195000852	Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422
246195000853	Plasmid maintenance system killer protein; Region: Plasmid_killer; pfam05015
246195000854	Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093
246195000855	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
246195000856	sequence-specific DNA binding site [nucleotide binding]; other site
246195000857	salt bridge; other site
246195000858	Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456
246195000859	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
246195000860	oligomeric interface; other site
246195000861	putative active site [active]
246195000862	homodimer interface [polypeptide binding]; other site
246195000863	Uncharacterized virulence-associated protein D [Function unknown]; Region: VapD; COG3309
246195000864	Predicted P-loop ATPase and inactivated derivatives [General function prediction only]; Region: COG5545
246195000865	Virulence-associated protein E; Region: VirE; pfam05272
246195000866	integrase; Provisional; Region: PRK09692
246195000867	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
246195000868	active site
246195000869	Int/Topo IB signature motif; other site
246195000870	carbon storage regulator; Provisional; Region: PRK01712
246195000871	aspartate kinase; Reviewed; Region: PRK06635
246195000872	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
246195000873	putative nucleotide binding site [chemical binding]; other site
246195000874	putative catalytic residues [active]
246195000875	putative Mg ion binding site [ion binding]; other site
246195000876	putative aspartate binding site [chemical binding]; other site
246195000877	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII and related proteins; Region: ACT_AK-LysC-DapG-like_1; cd04891
246195000878	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AK-LysC-DapG-like_2; cd04923
246195000879	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
246195000880	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
246195000881	motif 1; other site
246195000882	active site
246195000883	motif 2; other site
246195000884	motif 3; other site
246195000885	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
246195000886	DHHA1 domain; Region: DHHA1; pfam02272
246195000887	recombination regulator RecX; Reviewed; Region: recX; PRK00117
246195000888	recombinase A; Provisional; Region: recA; PRK09354
246195000889	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
246195000890	hexamer interface [polypeptide binding]; other site
246195000891	Walker A motif; other site
246195000892	ATP binding site [chemical binding]; other site
246195000893	Walker B motif; other site
246195000894	Tetratricopeptide repeat; Region: TPR_12; pfam13424
246195000895	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
246195000896	binding surface
246195000897	TPR motif; other site
246195000898	TPR repeat; Region: TPR_11; pfam13414
246195000899	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
246195000900	dimer interface [polypeptide binding]; other site
246195000901	active site
246195000902	Bacitracin resistance protein BacA; Region: BacA; pfam02673
246195000903	Preprotein translocase subunit SecB; Region: SecB; pfam02556
246195000904	SecA binding site; other site
246195000905	Preprotein binding site; other site
246195000906	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
246195000907	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
246195000908	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
246195000909	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
246195000910	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
246195000911	active site
246195000912	Domain of unknown function DUF20; Region: UPF0118; pfam01594
246195000913	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
246195000914	heme biosynthesis-associated TPR protein; Region: TPR_hemY_coli; TIGR00540
246195000915	Eukaryotic metallothionein; Region: Metallothio_Euk; pfam12749
246195000916	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
246195000917	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
246195000918	active site
246195000919	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
246195000920	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494
246195000921	domain interfaces; other site
246195000922	active site
246195000923	Protein of unknown function (DUF1342); Region: DUF1342; pfam07072
246195000924	Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530
246195000925	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
246195000926	homodimer interface [polypeptide binding]; other site
246195000927	oligonucleotide binding site [chemical binding]; other site
246195000928	Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955
246195000929	putative active site [active]
246195000930	transaldolase; Provisional; Region: PRK03903
246195000931	catalytic residue [active]
246195000932	Trm112p-like protein; Region: Trm112p; cl01066
246195000933	3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450
246195000934	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
246195000935	Ligand binding site; other site
246195000936	oligomer interface; other site
246195000937	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
246195000938	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
246195000939	GIY-YIG motif/motif A; other site
246195000940	active site
246195000941	catalytic site [active]
246195000942	putative DNA binding site [nucleotide binding]; other site
246195000943	metal binding site [ion binding]; metal-binding site
246195000944	UvrB/uvrC motif; Region: UVR; pfam02151
246195000945	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
246195000946	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
246195000947	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
246195000948	DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134
246195000949	dimer interface [polypeptide binding]; other site
246195000950	catalytic site [active]
246195000951	putative active site [active]
246195000952	putative substrate binding site [chemical binding]; other site
246195000953	Protein of unknown function (DUF2167); Region: DUF2167; cl01938
246195000954	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
246195000955	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
246195000956	active site
246195000957	Protein of unknown function (DUF406); Region: DUF406; pfam04175
246195000958	AMIN domain; Region: AMIN; pfam11741
246195000959	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
246195000960	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
246195000961	active site
246195000962	metal binding site [ion binding]; metal-binding site
246195000963	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931
246195000964	ligand binding site [chemical binding]; other site
246195000965	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
246195000966	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
246195000967	FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287
246195000968	active site 1 [active]
246195000969	dimer interface [polypeptide binding]; other site
246195000970	active site 2 [active]
246195000971	3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967
246195000972	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
246195000973	dimer interface [polypeptide binding]; other site
246195000974	active site
246195000975	Uncharacterized BCR, COG1636; Region: DUF208; pfam02677
246195000976	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
246195000977	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
246195000978	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
246195000979	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
246195000980	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
246195000981	ligand binding site [chemical binding]; other site
246195000982	DNA gyrase subunit A; Validated; Region: PRK05560
246195000983	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
246195000984	CAP-like domain; other site
246195000985	active site
246195000986	primary dimer interface [polypeptide binding]; other site
246195000987	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
246195000988	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
246195000989	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
246195000990	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
246195000991	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
246195000992	Protein of unknown function (DUF805); Region: DUF805; pfam05656
246195000993	Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171
246195000994	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
246195000995	tetramer interface [polypeptide binding]; other site
246195000996	pyridoxal 5'-phosphate binding site [chemical binding]; other site
246195000997	catalytic residue [active]
246195000998	replicative DNA helicase; Region: DnaB; TIGR00665
246195000999	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
246195001000	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
246195001001	Walker A motif; other site
246195001002	ATP binding site [chemical binding]; other site
246195001003	Walker B motif; other site
246195001004	DNA binding loops [nucleotide binding]
246195001005	alanine racemase; Reviewed; Region: alr; PRK00053
246195001006	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827
246195001007	active site
246195001008	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
246195001009	substrate binding site [chemical binding]; other site
246195001010	catalytic residues [active]
246195001011	dimer interface [polypeptide binding]; other site
246195001012	DNA repair protein RadA; Provisional; Region: PRK11823
246195001013	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
246195001014	Walker A motif/ATP binding site; other site
246195001015	ATP binding site [chemical binding]; other site
246195001016	Walker B motif; other site
246195001017	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
246195001018	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
246195001019	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
246195001020	active site
246195001021	tetramer interface; other site
246195001022	Transposase IS200 like; Region: Y1_Tnp; pfam01797
246195001023	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
246195001024	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
246195001025	TPP-binding site [chemical binding]; other site
246195001026	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
246195001027	dimer interface [polypeptide binding]; other site
246195001028	PYR/PP interface [polypeptide binding]; other site
246195001029	TPP binding site [chemical binding]; other site
246195001030	2-oxoglutarate dehydrogenase complex dihydrolipoamide succinyltransferase (E2 component); Region: sucB; TIGR01347
246195001031	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
246195001032	E3 interaction surface; other site
246195001033	lipoyl attachment site [posttranslational modification]; other site
246195001034	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
246195001035	Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658
246195001036	Competence protein; Region: Competence; pfam03772
246195001037	Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; pfam09835
246195001038	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
246195001039	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
246195001040	ligand binding site [chemical binding]; other site
246195001041	CshA-type fibril repeat; Region: CshA_fibril_rpt; TIGR04225
246195001042	CshA-type fibril repeat; Region: CshA_fibril_rpt; TIGR04225
246195001043	CshA-type fibril repeat; Region: CshA_fibril_rpt; TIGR04225
246195001044	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
246195001045	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
246195001046	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
246195001047	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
246195001048	Walker A/P-loop; other site
246195001049	ATP binding site [chemical binding]; other site
246195001050	Q-loop/lid; other site
246195001051	ABC transporter signature motif; other site
246195001052	Walker B; other site
246195001053	D-loop; other site
246195001054	H-loop/switch region; other site
246195001055	similar to hypothetical protein; identified by Glimmer2; putative
246195001056	UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562
246195001057	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
246195001058	UDP-galactopyranose mutase; Region: GLF; pfam03275
246195001059	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
246195001060	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
246195001061	active site
246195001062	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
246195001063	Bacterial sugar transferase; Region: Bac_transf; pfam02397
246195001064	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108
246195001065	Peptidase M15; Region: Peptidase_M15_3; cl01194
246195001066	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
246195001067	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
246195001068	N-acetyl-D-glucosamine binding site [chemical binding]; other site
246195001069	catalytic residue [active]
246195001070	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
246195001071	Competence protein A; Region: Competence_A; pfam11104
246195001072	Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166
246195001073	Fimbrial assembly protein (PilN); Region: PilN; pfam05137
246195001074	Pilus assembly protein, PilO; Region: PilO; pfam04350
246195001075	Pilus assembly protein, PilP; Region: PilP; pfam04351
246195001076	AMIN domain; Region: AMIN; pfam11741
246195001077	type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515
246195001078	Secretin and TonB N terminus short domain; Region: STN; smart00965
246195001079	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
246195001080	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
246195001081	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
246195001082	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
246195001083	GatB domain; Region: GatB_Yqey; smart00845
246195001084	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
246195001085	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
246195001086	G1 box; other site
246195001087	putative GEF interaction site [polypeptide binding]; other site
246195001088	GTP/Mg2+ binding site [chemical binding]; other site
246195001089	Switch I region; other site
246195001090	G2 box; other site
246195001091	G3 box; other site
246195001092	Switch II region; other site
246195001093	G4 box; other site
246195001094	G5 box; other site
246195001095	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
246195001096	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
246195001097	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
246195001098	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
246195001099	HIGH motif; other site
246195001100	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
246195001101	active site
246195001102	KMSKS motif; other site
246195001103	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
246195001104	tRNA binding surface [nucleotide binding]; other site
246195001105	anticodon binding site; other site
246195001106	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
246195001107	Peptidase family C69; Region: Peptidase_C69; pfam03577
246195001108	RNA polymerase-binding protein DksA; Region: dksA; TIGR02420
246195001109	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
246195001110	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
246195001111	ABC-ATPase subunit  interface; other site
246195001112	dimer interface [polypeptide binding]; other site
246195001113	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
246195001114	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
246195001115	Walker A/P-loop; other site
246195001116	ATP binding site [chemical binding]; other site
246195001117	Q-loop/lid; other site
246195001118	ABC transporter signature motif; other site
246195001119	Walker B; other site
246195001120	D-loop; other site
246195001121	H-loop/switch region; other site
246195001122	primosome assembly protein PriA; Validated; Region: PRK05580
246195001123	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
246195001124	ATP binding site [chemical binding]; other site
246195001125	putative Mg++ binding site [ion binding]; other site
246195001126	helicase superfamily c-terminal domain; Region: HELICc; smart00490
246195001127	chaperone protein DnaJ; Provisional; Region: PRK14293
246195001128	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
246195001129	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
246195001130	tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660
246195001131	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
246195001132	Ligand Binding Site [chemical binding]; other site
246195001133	TilS substrate C-terminal domain; Region: TilS_C; pfam11734
246195001134	CTP synthetase; Validated; Region: pyrG; PRK05380
246195001135	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
246195001136	Catalytic site [active]
246195001137	active site
246195001138	UTP binding site [chemical binding]; other site
246195001139	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
246195001140	active site
246195001141	putative oxyanion hole; other site
246195001142	catalytic triad [active]
246195001143	2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198
246195001144	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
246195001145	enolase; Provisional; Region: eno; PRK00077
246195001146	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
246195001147	dimer interface [polypeptide binding]; other site
246195001148	metal binding site [ion binding]; metal-binding site
246195001149	substrate binding pocket [chemical binding]; other site
246195001150	Septum formation initiator; Region: DivIC; cl17659
246195001151	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
246195001152	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
246195001153	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
246195001154	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
246195001155	Walker A/P-loop; other site
246195001156	ATP binding site [chemical binding]; other site
246195001157	Q-loop/lid; other site
246195001158	ABC transporter signature motif; other site
246195001159	Walker B; other site
246195001160	D-loop; other site
246195001161	H-loop/switch region; other site
246195001162	exonuclease subunit SbcD; Provisional; Region: PRK10966
246195001163	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
246195001164	active site
246195001165	metal binding site [ion binding]; metal-binding site
246195001166	DNA binding site [nucleotide binding]
246195001167	Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320
246195001168	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
246195001169	AAA domain; Region: AAA_23; pfam13476
246195001170	Walker A/P-loop; other site
246195001171	ATP binding site [chemical binding]; other site
246195001172	Q-loop/lid; other site
246195001173	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
246195001174	ABC transporter signature motif; other site
246195001175	Walker B; other site
246195001176	D-loop; other site
246195001177	H-loop/switch region; other site
246195001178	Yhdh and yhfp-like putative quinone oxidoreductases; Region: MDR_yhdh_yhfp; cd05280
246195001179	putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823
246195001180	NADP binding site [chemical binding]; other site
246195001181	dimer interface [polypeptide binding]; other site
246195001182	Domain of unknown function (DUF368); Region: DUF368; pfam04018
246195001183	Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248
246195001184	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
246195001185	Uncharacterized protein conserved in bacteria [Function unknown]; Region: CreA; COG3045
246195001186	CreA protein; Region: CreA; pfam05981
246195001187	Predicted periplasmic protein [Function unknown]; Region: COG3698
246195001188	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
246195001189	Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585
246195001190	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
246195001191	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
246195001192	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
246195001193	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
246195001194	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
246195001195	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
246195001196	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
246195001197	active site
246195001198	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
246195001199	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
246195001200	substrate binding pocket [chemical binding]; other site
246195001201	membrane-bound complex binding site; other site
246195001202	hinge residues; other site
246195001203	GMP synthase; Reviewed; Region: guaA; PRK00074
246195001204	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
246195001205	AMP/PPi binding site [chemical binding]; other site
246195001206	candidate oxyanion hole; other site
246195001207	catalytic triad [active]
246195001208	potential glutamine specificity residues [chemical binding]; other site
246195001209	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
246195001210	ATP Binding subdomain [chemical binding]; other site
246195001211	Ligand Binding sites [chemical binding]; other site
246195001212	Dimerization subdomain; other site
246195001213	ATP-dependent DNA helicase Rep; Region: rep; TIGR01074
246195001214	Part of AAA domain; Region: AAA_19; pfam13245
246195001215	Family description; Region: UvrD_C_2; pfam13538
246195001216	similar to outer membrane protein 1B
246195001217	Transferrin binding protein-like solute binding protein; Region: Lipoprotein_5; pfam01298
246195001218	Transferrin binding protein-like solute binding protein; Region: Lipoprotein_5; pfam01298
246195001219	similar to outer membrane protein 1A
246195001220	Transposase IS200 like; Region: Y1_Tnp; pfam01797
246195001221	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
246195001222	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
246195001223	Probable transposase; Region: OrfB_IS605; pfam01385
246195001224	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
246195001225	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
246195001226	catalytic core [active]
246195001227	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
246195001228	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
246195001229	nucleotide binding pocket [chemical binding]; other site
246195001230	K-X-D-G motif; other site
246195001231	catalytic site [active]
246195001232	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
246195001233	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
246195001234	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
246195001235	Dimer interface [polypeptide binding]; other site
246195001236	ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cl12038
246195001237	FtsZ protein binding site [polypeptide binding]; other site
246195001238	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
246195001239	G1 box; other site
246195001240	GTP/Mg2+ binding site [chemical binding]; other site
246195001241	Switch I region; other site
246195001242	G2 box; other site
246195001243	G3 box; other site
246195001244	Switch II region; other site
246195001245	G4 box; other site
246195001246	G5 box; other site
246195001247	hypothetical protein; Provisional; Region: PRK10621
246195001248	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
246195001249	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
246195001250	active site
246195001251	homotetramer interface [polypeptide binding]; other site
246195001252	homodimer interface [polypeptide binding]; other site
246195001253	putative protease; Provisional; Region: PRK15452
246195001254	Peptidase family U32; Region: Peptidase_U32; pfam01136
246195001255	S-ribosylhomocysteinase; Provisional; Region: PRK02260
246195001256	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
246195001257	ClC chloride channel family. These protein sequences, closely related to the ClC Eric family, are putative halogen ion (Cl-, Br- and I-) transport proteins found in eubacteria. They belong to the ClC superfamily of chloride ion channels, which share a...; Region: EriC_like; cd01034
246195001258	putative ion selectivity filter; other site
246195001259	putative pore gating glutamate residue; other site
246195001260	putative H+/Cl- coupling transport residue; other site
246195001261	4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337
246195001262	UbiA prenyltransferase family; Region: UbiA; pfam01040
246195001263	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
246195001264	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
246195001265	Walker A/P-loop; other site
246195001266	ATP binding site [chemical binding]; other site
246195001267	Q-loop/lid; other site
246195001268	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
246195001269	ABC transporter signature motif; other site
246195001270	Walker B; other site
246195001271	D-loop; other site
246195001272	ABC transporter; Region: ABC_tran_2; pfam12848
246195001273	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
246195001274	glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
246195001275	DJ-1 family protein; Region: not_thiJ; TIGR01383
246195001276	Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135
246195001277	conserved cys residue [active]
246195001278	Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286
246195001279	Colicin V production protein; Region: Colicin_V; pfam02674
246195001280	Sporulation related domain; Region: SPOR; pfam05036
246195001281	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
246195001282	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
246195001283	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
246195001284	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
246195001285	Predicted small secreted protein [Function unknown]; Region: COG5510
246195001286	AAA domain; Region: AAA_30; pfam13604
246195001287	Family description; Region: UvrD_C_2; pfam13538
246195001288	Predicted permeases [General function prediction only]; Region: COG0701
246195001289	Thioredoxin domain; Region: Thioredoxin_3; pfam13192
246195001290	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
246195001291	active site
246195001292	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
246195001293	active site
246195001294	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179
246195001295	Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755
246195001296	putative ATP binding site [chemical binding]; other site
246195001297	putative substrate interface [chemical binding]; other site
246195001298	50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678
246195001299	thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293
246195001300	Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412
246195001301	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
246195001302	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
246195001303	Dehydroquinase class II; Region: DHquinase_II; pfam01220
246195001304	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
246195001305	active site
246195001306	trimer interface [polypeptide binding]; other site
246195001307	dimer interface [polypeptide binding]; other site
246195001308	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
246195001309	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
246195001310	carboxyltransferase (CT) interaction site; other site
246195001311	biotinylation site [posttranslational modification]; other site
246195001312	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
246195001313	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
246195001314	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
246195001315	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
246195001316	Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325
246195001317	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
246195001318	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
246195001319	FMN binding site [chemical binding]; other site
246195001320	active site
246195001321	catalytic residues [active]
246195001322	substrate binding site [chemical binding]; other site
246195001323	Uncharacterized ACR, COG1430; Region: DUF192; pfam02643
246195001324	gliding motility-associated protein GldE; Region: GldE; TIGR03520
246195001325	Domain of unknown function DUF21; Region: DUF21; pfam01595
246195001326	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
246195001327	Transporter associated domain; Region: CorC_HlyC; smart01091
246195001328	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
246195001329	signal recognition particle protein; Provisional; Region: PRK10867
246195001330	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
246195001331	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
246195001332	P loop; other site
246195001333	GTP binding site [chemical binding]; other site
246195001334	Signal peptide binding domain; Region: SRP_SPB; pfam02978
246195001335	Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195
246195001336	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
246195001337	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087
246195001338	active site
246195001339	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
246195001340	putative catalytic site [active]
246195001341	putative phosphate binding site [ion binding]; other site
246195001342	active site
246195001343	metal binding site A [ion binding]; metal-binding site
246195001344	DNA binding site [nucleotide binding]
246195001345	putative AP binding site [nucleotide binding]; other site
246195001346	putative metal binding site B [ion binding]; other site
246195001347	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
246195001348	RNA methyltransferase, RsmE family; Region: TIGR00046
246195001349	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
246195001350	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
246195001351	dimer interface [polypeptide binding]; other site
246195001352	phosphorylation site [posttranslational modification]
246195001353	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
246195001354	ATP binding site [chemical binding]; other site
246195001355	Mg2+ binding site [ion binding]; other site
246195001356	G-X-G motif; other site
246195001357	transcriptional regulatory protein ZraR; Provisional; Region: PRK10365
246195001358	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
246195001359	active site
246195001360	phosphorylation site [posttranslational modification]
246195001361	intermolecular recognition site; other site
246195001362	dimerization interface [polypeptide binding]; other site
246195001363	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
246195001364	Walker A motif; other site
246195001365	ATP binding site [chemical binding]; other site
246195001366	Walker B motif; other site
246195001367	arginine finger; other site
246195001368	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
246195001369	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046
246195001370	FAD binding domain; Region: FAD_binding_4; pfam01565
246195001371	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
246195001372	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
246195001373	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
246195001374	motif II; other site
246195001375	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3536
246195001376	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
246195001377	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
246195001378	S-adenosylmethionine binding site [chemical binding]; other site
246195001379	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165
246195001380	SCP-2 sterol transfer family; Region: SCP2; pfam02036
246195001381	Membrane fusogenic activity; Region: BMFP; pfam04380
246195001382	ABC1 family; Region: ABC1; cl17513
246195001383	2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982
246195001384	tyrosine phenol-lyase; Provisional; Region: PRK13237
246195001385	Tryptophanase family (Tnase). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to tryptophanase (Tnase) and tyrosine phenol-lyase (TPL). Tnase and TPL are...; Region: Tnase_like; cd00617
246195001386	substrate binding site [chemical binding]; other site
246195001387	tetramer interface [polypeptide binding]; other site
246195001388	catalytic residue [active]
246195001389	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
246195001390	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
246195001391	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
246195001392	Walker A/P-loop; other site
246195001393	ATP binding site [chemical binding]; other site
246195001394	Q-loop/lid; other site
246195001395	ABC transporter signature motif; other site
246195001396	Walker B; other site
246195001397	D-loop; other site
246195001398	H-loop/switch region; other site
246195001399	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
246195001400	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
246195001401	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
246195001402	Walker A/P-loop; other site
246195001403	ATP binding site [chemical binding]; other site
246195001404	Q-loop/lid; other site
246195001405	ABC transporter signature motif; other site
246195001406	Walker B; other site
246195001407	D-loop; other site
246195001408	H-loop/switch region; other site
246195001409	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
246195001410	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
246195001411	RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399
246195001412	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
246195001413	propionate/acetate kinase; Provisional; Region: PRK12379
246195001414	phosphate acetyltransferase; Reviewed; Region: PRK05632
246195001415	DRTGG domain; Region: DRTGG; pfam07085
246195001416	Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212
246195001417	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
246195001418	sec-independent translocase; Provisional; Region: PRK00708
246195001419	twin arginine-targeting protein translocase TatB; Region: tatB; TIGR01410
246195001420	Sec-independent protein translocase protein (TatC); Region: TatC; cl00521
246195001421	oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104
246195001422	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
246195001423	peptide binding site [polypeptide binding]; other site
246195001424	oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471
246195001425	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
246195001426	dimer interface [polypeptide binding]; other site
246195001427	conserved gate region; other site
246195001428	putative PBP binding loops; other site
246195001429	ABC-ATPase subunit interface; other site
246195001430	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
246195001431	oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406
246195001432	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
246195001433	dimer interface [polypeptide binding]; other site
246195001434	conserved gate region; other site
246195001435	putative PBP binding loops; other site
246195001436	ABC-ATPase subunit interface; other site
246195001437	ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172
246195001438	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
246195001439	Walker A/P-loop; other site
246195001440	ATP binding site [chemical binding]; other site
246195001441	Q-loop/lid; other site
246195001442	ABC transporter signature motif; other site
246195001443	Walker B; other site
246195001444	D-loop; other site
246195001445	H-loop/switch region; other site
246195001446	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
246195001447	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
246195001448	Walker A/P-loop; other site
246195001449	ATP binding site [chemical binding]; other site
246195001450	Q-loop/lid; other site
246195001451	ABC transporter signature motif; other site
246195001452	Walker B; other site
246195001453	D-loop; other site
246195001454	H-loop/switch region; other site
246195001455	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
246195001456	DNA polymerase III chi subunit, HolC; Region: DNA_pol3_chi; pfam04364
246195001457	Flavodoxin domain; Region: Flavodoxin_5; cl17428
246195001458	similar to hypothetical protein; identified by Glimmer2; putative
246195001459	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
246195001460	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
246195001461	active site
246195001462	intracellular septation protein A; Reviewed; Region: PRK00259
246195001463	iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090
246195001464	Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate  into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354
246195001465	AMP binding site [chemical binding]; other site
246195001466	metal binding site [ion binding]; metal-binding site
246195001467	active site
246195001468	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
246195001469	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
246195001470	putative DNA binding site [nucleotide binding]; other site
246195001471	putative Zn2+ binding site [ion binding]; other site
246195001472	AsnC family; Region: AsnC_trans_reg; pfam01037
246195001473	transcription antitermination factor NusB; Region: nusB; TIGR01951
246195001474	putative RNA binding site [nucleotide binding]; other site
246195001475	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
246195001476	homopentamer interface [polypeptide binding]; other site
246195001477	active site
246195001478	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019
246195001479	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
246195001480	GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925
246195001481	dimerization interface [polypeptide binding]; other site
246195001482	active site
246195001483	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
246195001484	Lumazine binding domain; Region: Lum_binding; pfam00677
246195001485	Lumazine binding domain; Region: Lum_binding; pfam00677
246195001486	bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786
246195001487	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
246195001488	catalytic motif [active]
246195001489	Zn binding site [ion binding]; other site
246195001490	RibD C-terminal domain; Region: RibD_C; cl17279
246195001491	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
246195001492	ATP cone domain; Region: ATP-cone; pfam03477
246195001493	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
246195001494	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
246195001495	dimer interface [polypeptide binding]; other site
246195001496	active site
246195001497	glycine-pyridoxal phosphate binding site [chemical binding]; other site
246195001498	folate binding site [chemical binding]; other site
246195001499	ScpA/B protein; Region: ScpA_ScpB; cl00598
246195001500	Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079
246195001501	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
246195001502	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
246195001503	RNA binding surface [nucleotide binding]; other site
246195001504	Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556
246195001505	probable active site [active]
246195001506	lipoyl synthase; Provisional; Region: PRK05481
246195001507	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
246195001508	FeS/SAM binding site; other site
246195001509	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
246195001510	S-adenosylmethionine binding site [chemical binding]; other site
246195001511	Methyltransferase domain; Region: Methyltransf_23; pfam13489
246195001512	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
246195001513	S-adenosylmethionine binding site [chemical binding]; other site
246195001514	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
246195001515	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
246195001516	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
246195001517	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
246195001518	lipoprotein chaperone; Reviewed; Region: lolA; PRK00031
246195001519	Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548
246195001520	recombination factor protein RarA; Reviewed; Region: PRK13342
246195001521	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
246195001522	Walker A motif; other site
246195001523	ATP binding site [chemical binding]; other site
246195001524	Walker B motif; other site
246195001525	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
246195001526	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
246195001527	50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278
246195001528	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
246195001529	Obg family GTPase CgtA; Region: Obg_CgtA; TIGR02729
246195001530	GTP1/OBG; Region: GTP1_OBG; pfam01018
246195001531	Obg GTPase; Region: Obg; cd01898
246195001532	G1 box; other site
246195001533	GTP/Mg2+ binding site [chemical binding]; other site
246195001534	Switch I region; other site
246195001535	G2 box; other site
246195001536	G3 box; other site
246195001537	Switch II region; other site
246195001538	G4 box; other site
246195001539	G5 box; other site
246195001540	Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577
246195001541	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
246195001542	aspartate carbamoyltransferase; Provisional; Region: PRK08192
246195001543	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
246195001544	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
246195001545	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
246195001546	putative active site [active]
246195001547	dimerization interface [polypeptide binding]; other site
246195001548	putative tRNAtyr binding site [nucleotide binding]; other site
246195001549	Maf-like protein; Region: Maf; pfam02545
246195001550	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
246195001551	active site
246195001552	dimer interface [polypeptide binding]; other site
246195001553	ribonuclease G; Provisional; Region: PRK11712
246195001554	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
246195001555	homodimer interface [polypeptide binding]; other site
246195001556	oligonucleotide binding site [chemical binding]; other site
246195001557	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
246195001558	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
246195001559	eyelet of channel; other site
246195001560	trimer interface [polypeptide binding]; other site
246195001561	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
246195001562	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
246195001563	eyelet of channel; other site
246195001564	trimer interface [polypeptide binding]; other site
246195001565	Protein of unknown function (DUF330); Region: DUF330; pfam03886
246195001566	Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008
246195001567	mce related protein; Region: MCE; pfam02470
246195001568	mce related protein; Region: MCE; pfam02470
246195001569	mce related protein; Region: MCE; pfam02470
246195001570	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
246195001571	YccA-like proteins; Region: YccA_like; cd10433
246195001572	Putative lipopolysaccharide-modifying enzyme; Region: CAP10; smart00672
246195001573	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
246195001574	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
246195001575	G1 box; other site
246195001576	putative GEF interaction site [polypeptide binding]; other site
246195001577	GTP/Mg2+ binding site [chemical binding]; other site
246195001578	Switch I region; other site
246195001579	G2 box; other site
246195001580	G3 box; other site
246195001581	Switch II region; other site
246195001582	G4 box; other site
246195001583	G5 box; other site
246195001584	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
246195001585	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
246195001586	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
246195001587	substrate binding pocket [chemical binding]; other site
246195001588	membrane-bound complex binding site; other site
246195001589	hinge residues; other site
246195001590	malonic semialdehyde reductase; Provisional; Region: PRK10538
246195001591	classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346
246195001592	putative NAD(P) binding site [chemical binding]; other site
246195001593	homotetramer interface [polypeptide binding]; other site
246195001594	homodimer interface [polypeptide binding]; other site
246195001595	active site
246195001596	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
246195001597	putative transporter; Provisional; Region: PRK10504
246195001598	putative substrate translocation pore; other site
246195001599	diphosphomevalonate decarboxylase; Region: PLN02407
246195001600	diphosphomevalonate decarboxylase; Region: mevDPdecarb; TIGR01240
246195001601	diphosphomevalonate decarboxylase; Region: PLN02407
246195001602	fumarate hydratase; Reviewed; Region: fumC; PRK00485
246195001603	Class II fumarases; Region: Fumarase_classII; cd01362
246195001604	active site
246195001605	tetramer interface [polypeptide binding]; other site
246195001606	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
246195001607	trimer interface [polypeptide binding]; other site
246195001608	active site
246195001609	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489
246195001610	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
246195001611	Walker A motif; other site
246195001612	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
246195001613	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
246195001614	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
246195001615	shikimate binding site; other site
246195001616	NAD(P) binding site [chemical binding]; other site
246195001617	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823
246195001618	dimer interface [polypeptide binding]; other site
246195001619	allosteric magnesium binding site [ion binding]; other site
246195001620	active site
246195001621	aspartate-rich active site metal binding site; other site
246195001622	Schiff base residues; other site
246195001623	DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019
246195001624	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
246195001625	catalytic residues [active]
246195001626	hinge region; other site
246195001627	alpha helical domain; other site
246195001628	Phosphotransferase enzyme family; Region: APH; pfam01636
246195001629	Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178
246195001630	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
246195001631	NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422
246195001632	Substrate binding site; other site
246195001633	metal-binding site
246195001634	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194
246195001635	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
246195001636	FeS/SAM binding site; other site
246195001637	type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521
246195001638	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
246195001639	binding surface
246195001640	TPR motif; other site
246195001641	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
246195001642	non-specific DNA binding site [nucleotide binding]; other site
246195001643	salt bridge; other site
246195001644	sequence-specific DNA binding site [nucleotide binding]; other site
246195001645	Domain of unknown function (DUF4115); Region: DUF4115; pfam13464
246195001646	histidyl-tRNA synthetase; Region: hisS; TIGR00442
246195001647	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
246195001648	dimer interface [polypeptide binding]; other site
246195001649	motif 1; other site
246195001650	active site
246195001651	motif 2; other site
246195001652	motif 3; other site
246195001653	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
246195001654	anticodon binding site; other site
246195001655	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976
246195001656	outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300
246195001657	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
246195001658	Trp docking motif [polypeptide binding]; other site
246195001659	active site
246195001660	ribosome-associated GTPase EngA; Region: GTPase_EngA; TIGR03594
246195001661	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
246195001662	G1 box; other site
246195001663	GTP/Mg2+ binding site [chemical binding]; other site
246195001664	Switch I region; other site
246195001665	G2 box; other site
246195001666	Switch II region; other site
246195001667	G3 box; other site
246195001668	G4 box; other site
246195001669	G5 box; other site
246195001670	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
246195001671	G1 box; other site
246195001672	GTP/Mg2+ binding site [chemical binding]; other site
246195001673	Switch I region; other site
246195001674	G2 box; other site
246195001675	G3 box; other site
246195001676	Switch II region; other site
246195001677	G4 box; other site
246195001678	G5 box; other site
246195001679	Protein of unknown function (DUF819); Region: DUF819; cl02317
246195001680	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
246195001681	tetramer (dimer of dimers) interface [polypeptide binding]; other site
246195001682	active site
246195001683	dimer interface [polypeptide binding]; other site
246195001684	Flavinator of succinate dehydrogenase; Region: Sdh5; cl01110
246195001685	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
246195001686	23S rRNA binding site [nucleotide binding]; other site
246195001687	L21 binding site [polypeptide binding]; other site
246195001688	L13 binding site [polypeptide binding]; other site
246195001689	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
246195001690	similar to translation initiation factor IF-3; identified by match to protein family HMM PF00707; match to protein family HMM PF05198; match to protein family HMM TIGR00168
246195001691	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
246195001692	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
246195001693	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
246195001694	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
246195001695	active site
246195001696	dimer interface [polypeptide binding]; other site
246195001697	motif 1; other site
246195001698	motif 2; other site
246195001699	motif 3; other site
246195001700	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
246195001701	anticodon binding site; other site
246195001702	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
246195001703	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
246195001704	glutaminase active site [active]
246195001705	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
246195001706	dimer interface [polypeptide binding]; other site
246195001707	active site
246195001708	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
246195001709	dimer interface [polypeptide binding]; other site
246195001710	active site
246195001711	PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396
246195001712	active site
246195001713	Domain of unknown function (DUF1705); Region: DUF1705; pfam08019
246195001714	Sulfatase; Region: Sulfatase; pfam00884
246195001715	3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826
246195001716	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
246195001717	NAD(P) binding site [chemical binding]; other site
246195001718	active site
246195001719	RNA polymerase factor sigma-54; Reviewed; Region: PRK05932
246195001720	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
246195001721	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
246195001722	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
246195001723	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
246195001724	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
246195001725	Walker A/P-loop; other site
246195001726	ATP binding site [chemical binding]; other site
246195001727	Q-loop/lid; other site
246195001728	ABC transporter signature motif; other site
246195001729	Walker B; other site
246195001730	D-loop; other site
246195001731	H-loop/switch region; other site
246195001732	lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002
246195001733	OstA-like protein; Region: OstA; pfam03968
246195001734	Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835
246195001735	D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892
246195001736	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
246195001737	putative active site [active]
246195001738	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
246195001739	phosphoglycolate phosphatase; Provisional; Region: PRK13222
246195001740	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
246195001741	motif II; other site
246195001742	bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134
246195001743	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
246195001744	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
246195001745	S-adenosylmethionine binding site [chemical binding]; other site
246195001746	PA14 domain; Region: PA14; cl08459
246195001747	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
246195001748	ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163
246195001749	substrate binding site [chemical binding]; other site
246195001750	hexamer interface [polypeptide binding]; other site
246195001751	metal binding site [ion binding]; metal-binding site
246195001752	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
246195001753	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
246195001754	Type III pantothenate kinase; Region: Pan_kinase; cl17198
246195001755	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
246195001756	C-terminal peptidase (prc); Region: prc; TIGR00225
246195001757	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
246195001758	protein binding site [polypeptide binding]; other site
246195001759	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
246195001760	Catalytic dyad [active]
246195001761	pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405
246195001762	Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017
246195001763	dimer interface [polypeptide binding]; other site
246195001764	TPP-binding site [chemical binding]; other site
246195001765	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
246195001766	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
246195001767	E3 interaction surface; other site
246195001768	lipoyl attachment site [posttranslational modification]; other site
246195001769	e3 binding domain; Region: E3_binding; pfam02817
246195001770	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
246195001771	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
246195001772	type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375
246195001773	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296
246195001774	putative active site [active]
246195001775	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
246195001776	ATP-binding cassette domain of bacteriocin exporters, subfamily C; Region: ABCC_bacteriocin_exporters; cd03245
246195001777	Walker A/P-loop; other site
246195001778	ATP binding site [chemical binding]; other site
246195001779	Q-loop/lid; other site
246195001780	ABC transporter signature motif; other site
246195001781	Walker B; other site
246195001782	D-loop; other site
246195001783	H-loop/switch region; other site
246195001784	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
246195001785	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
246195001786	HlyD family secretion protein; Region: HlyD_3; pfam13437
246195001787	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
246195001788	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
246195001789	minor groove reading motif; other site
246195001790	helix-hairpin-helix signature motif; other site
246195001791	substrate binding pocket [chemical binding]; other site
246195001792	active site
246195001793	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576
246195001794	electron transport complex RsxE subunit; Provisional; Region: PRK12405
246195001795	FMN-binding domain; Region: FMN_bind; cl01081
246195001796	NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; pfam03116
246195001797	electron transport complex, RnfABCDGE type, C subunit; Region: rnfC; TIGR01945
246195001798	SLBB domain; Region: SLBB; pfam10531
246195001799	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
246195001800	ferredoxin; Provisional; Region: PRK08764
246195001801	Putative Fe-S cluster; Region: FeS; pfam04060
246195001802	4Fe-4S binding domain; Region: Fer4; pfam00037
246195001803	electron transport complex protein RsxA; Provisional; Region: PRK05151
246195001804	Protein of unknown function (DUF2959); Region: DUF2959; pfam11172
246195001805	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
246195001806	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
246195001807	catalytic triad [active]
246195001808	excinuclease ABC subunit B; Provisional; Region: PRK05298
246195001809	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
246195001810	ATP binding site [chemical binding]; other site
246195001811	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
246195001812	nucleotide binding region [chemical binding]; other site
246195001813	ATP-binding site [chemical binding]; other site
246195001814	Ultra-violet resistance protein B; Region: UvrB; pfam12344
246195001815	UvrB/uvrC motif; Region: UVR; pfam02151
246195001816	Domain of unknown function (DUF4422); Region: DUF4422; pfam14393
246195001817	A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194
246195001818	Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501
246195001819	Ligand binding site; other site
246195001820	metal-binding site
246195001821	Smr domain; Region: Smr; pfam01713
246195001822	dihydrodipicolinate reductase; Provisional; Region: PRK00048
246195001823	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
246195001824	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
246195001825	Protein of unknown function (DUF1049); Region: DUF1049; cl01539
246195001826	tetratricopeptide repeat protein; Provisional; Region: PRK11788
246195001827	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
246195001828	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
246195001829	active site
246195001830	dimer interface [polypeptide binding]; other site
246195001831	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
246195001832	CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473
246195001833	SH3 domain protein; Region: SH3_and_anchor; TIGR04211
246195001834	Bacterial SH3 domain; Region: SH3_3; cl17532
246195001835	Protein of unknown function (DUF2968); Region: DUF2968; pfam11180
246195001836	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
246195001837	thymidylate synthase; Reviewed; Region: thyA; PRK01827
246195001838	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
246195001839	dimerization interface [polypeptide binding]; other site
246195001840	active site
246195001841	penicillin-binding protein 1B; Region: PBP_1b; TIGR02071
246195001842	Transglycosylase; Region: Transgly; pfam00912
246195001843	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
246195001844	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
246195001845	binding surface
246195001846	Tetratricopeptide repeat; Region: TPR_16; pfam13432
246195001847	TPR motif; other site
246195001848	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
246195001849	DEAD/DEAH box helicase; Region: DEAD; pfam00270
246195001850	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
246195001851	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
246195001852	Glycoprotease family; Region: Peptidase_M22; pfam00814
246195001853	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
246195001854	active site
246195001855	Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249
246195001856	GTP/Mg2+ binding site [chemical binding]; other site
246195001857	G5 box; other site
246195001858	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
246195001859	G1 box; other site
246195001860	G1 box; other site
246195001861	GTP/Mg2+ binding site [chemical binding]; other site
246195001862	Switch I region; other site
246195001863	G2 box; other site
246195001864	G2 box; other site
246195001865	Switch I region; other site
246195001866	G3 box; other site
246195001867	Switch II region; other site
246195001868	G4 box; other site
246195001869	G5 box; other site
246195001870	Dynamin family; Region: Dynamin_N; pfam00350
246195001871	E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880
246195001872	G1 box; other site
246195001873	GTP/Mg2+ binding site [chemical binding]; other site
246195001874	Switch I region; other site
246195001875	G2 box; other site
246195001876	Switch II region; other site
246195001877	G3 box; other site
246195001878	G4 box; other site
246195001879	G5 box; other site
246195001880	Domain of unknown function (DUF697); Region: DUF697; pfam05128
246195001881	protease TldD; Provisional; Region: tldD; PRK10735
246195001882	peptidase PmbA; Provisional; Region: PRK11040
246195001883	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
246195001884	nucleoside/Zn binding site; other site
246195001885	dimer interface [polypeptide binding]; other site
246195001886	catalytic motif [active]
246195001887	Ion channel; Region: Ion_trans_2; pfam07885
246195001888	TrkA-N domain; Region: TrkA_N; pfam02254
246195001889	TrkA-N domain; Region: TrkA_N; pfam02254
246195001890	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
246195001891	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
246195001892	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
246195001893	putative substrate binding site [chemical binding]; other site
246195001894	putative ATP binding site [chemical binding]; other site
246195001895	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
246195001896	pseudouridine synthase; Region: TIGR00093
246195001897	active site
246195001898	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
246195001899	active site
246195001900	ribulose/triose binding site [chemical binding]; other site
246195001901	phosphate binding site [ion binding]; other site
246195001902	substrate (anthranilate) binding pocket [chemical binding]; other site
246195001903	product (indole) binding pocket [chemical binding]; other site
246195001904	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
246195001905	active site
246195001906	Protein of unknown function (DUF3108); Region: DUF3108; pfam11306
246195001907	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
246195001908	FeS/SAM binding site; other site
246195001909	Lysine-2,3-aminomutase; Region: LAM_C; pfam12544
246195001910	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
246195001911	DHH family; Region: DHH; pfam01368
246195001912	DHHA1 domain; Region: DHHA1; pfam02272
246195001913	SlyX; Region: SlyX; pfam04102
246195001914	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
246195001915	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
246195001916	active site
246195001917	motif I; other site
246195001918	motif II; other site
246195001919	Chitin synthase III catalytic subunit; Region: Chs3p; pfam12271
246195001920	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
246195001921	bacterial Hfq-like; Region: Hfq; cd01716
246195001922	hexamer interface [polypeptide binding]; other site
246195001923	Sm1 motif; other site
246195001924	RNA binding site [nucleotide binding]; other site
246195001925	Sm2 motif; other site
246195001926	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
246195001927	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
246195001928	HflX GTPase family; Region: HflX; cd01878
246195001929	G1 box; other site
246195001930	GTP/Mg2+ binding site [chemical binding]; other site
246195001931	Switch I region; other site
246195001932	G2 box; other site
246195001933	G3 box; other site
246195001934	Switch II region; other site
246195001935	G4 box; other site
246195001936	G5 box; other site
246195001937	Bacterial membrane protein N terminal; Region: HflK_N; pfam12221
246195001938	Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404
246195001939	HflK protein; Region: hflK; TIGR01933
246195001940	HflC protein; Region: hflC; TIGR01932
246195001941	Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405
246195001942	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
246195001943	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
246195001944	GDP-binding site [chemical binding]; other site
246195001945	ACT binding site; other site
246195001946	IMP binding site; other site
246195001947	ribonuclease R; Region: RNase_R; TIGR02063
246195001948	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
246195001949	RNB domain; Region: RNB; pfam00773
246195001950	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
246195001951	RNA binding site [nucleotide binding]; other site
246195001952	23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181
246195001953	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
246195001954	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
246195001955	Peptidase S8 family domain, uncharacterized subfamily 13; Region: Peptidases_S8_13; cd07496
246195001956	active site
246195001957	catalytic triad [active]
246195001958	Proprotein convertase P-domain; Region: P_proprotein; pfam01483
246195001959	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
246195001960	EF-P lysine aminoacylase GenX; Region: genX; TIGR00462
246195001961	motif 1; other site
246195001962	dimer interface [polypeptide binding]; other site
246195001963	active site
246195001964	motif 2; other site
246195001965	motif 3; other site
246195001966	Peptidase S8 family domain, uncharacterized subfamily 13; Region: Peptidases_S8_13; cd07496
246195001967	active site
246195001968	catalytic triad [active]
246195001969	Proprotein convertase P-domain; Region: P_proprotein; pfam01483
246195001970	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
246195001971	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
246195001972	substrate binding pocket [chemical binding]; other site
246195001973	membrane-bound complex binding site; other site
246195001974	hinge residues; other site
246195001975	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09102
246195001976	Class I ribonucleotide reductase; Region: RNR_I; cd01679
246195001977	active site
246195001978	dimer interface [polypeptide binding]; other site
246195001979	catalytic residues [active]
246195001980	effector binding site; other site
246195001981	R2 peptide binding site; other site
246195001982	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
246195001983	dimer interface [polypeptide binding]; other site
246195001984	putative radical transfer pathway; other site
246195001985	diiron center [ion binding]; other site
246195001986	tyrosyl radical; other site
246195001987	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
246195001988	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
246195001989	Walker A/P-loop; other site
246195001990	ATP binding site [chemical binding]; other site
246195001991	Q-loop/lid; other site
246195001992	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
246195001993	ABC transporter signature motif; other site
246195001994	Walker B; other site
246195001995	D-loop; other site
246195001996	H-loop/switch region; other site
246195001997	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
246195001998	PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765
246195001999	active site
246195002000	phosphorylation site [posttranslational modification]
246195002001	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
246195002002	active site
246195002003	P-loop; other site
246195002004	phosphorylation site [posttranslational modification]
246195002005	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
246195002006	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
246195002007	Shikimate kinase; Region: SKI; pfam01202
246195002008	ADP binding site [chemical binding]; other site
246195002009	magnesium binding site [ion binding]; other site
246195002010	putative shikimate binding site; other site
246195002011	DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939
246195002012	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
246195002013	Mg2+ binding site [ion binding]; other site
246195002014	G-X-G motif; other site
246195002015	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
246195002016	anchoring element; other site
246195002017	dimer interface [polypeptide binding]; other site
246195002018	ATP binding site [chemical binding]; other site
246195002019	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
246195002020	active site
246195002021	putative metal-binding site [ion binding]; other site
246195002022	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
246195002023	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
246195002024	30S subunit binding site; other site
246195002025	polyhydroxyalkanoate synthesis repressor PhaR; Region: PHA_reg_PhaR; TIGR01848
246195002026	PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879
246195002027	PHB accumulation regulatory domain; Region: PHB_acc; pfam05233
246195002028	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
246195002029	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
246195002030	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
246195002031	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
246195002032	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
246195002033	ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967
246195002034	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
246195002035	ATP binding site [chemical binding]; other site
246195002036	putative Mg++ binding site [ion binding]; other site
246195002037	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
246195002038	nucleotide binding region [chemical binding]; other site
246195002039	ATP-binding site [chemical binding]; other site
246195002040	Helicase associated domain (HA2); Region: HA2; pfam04408
246195002041	Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717
246195002042	Domain of unknown function (DUF3418); Region: DUF3418; pfam11898
246195002043	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584
246195002044	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704
246195002045	glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274
246195002046	glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273
246195002047	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
246195002048	Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191
246195002049	Ligand binding site; other site
246195002050	DXD motif; other site
246195002051	tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054
246195002052	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
246195002053	Ligand Binding Site [chemical binding]; other site
246195002054	putative lysogenization regulator; Reviewed; Region: PRK00218
246195002055	PEP synthetase regulatory protein; Provisional; Region: PRK05339
246195002056	phosphoenolpyruvate synthase; Validated; Region: PRK06464
246195002057	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
246195002058	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
246195002059	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
246195002060	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
246195002061	ligand binding site [chemical binding]; other site
246195002062	active site
246195002063	UGI interface [polypeptide binding]; other site
246195002064	catalytic site [active]
246195002065	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
246195002066	N-acetyl-D-glucosamine binding site [chemical binding]; other site
246195002067	catalytic residue [active]
246195002068	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
246195002069	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
246195002070	N-acetyl-D-glucosamine binding site [chemical binding]; other site
246195002071	catalytic residue [active]
246195002072	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
246195002073	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
246195002074	N-acetyl-D-glucosamine binding site [chemical binding]; other site
246195002075	catalytic residue [active]
246195002076	The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual proteins of this...; Region: Band_7; cl02525
246195002077	Domain of unknown function (DUF4339); Region: DUF4339; pfam14237
246195002078	Toxic anion resistance protein (TelA); Region: TelA; pfam05816
246195002079	hypothetical protein; Reviewed; Region: PRK12497
246195002080	Predicted methyltransferases [General function prediction only]; Region: COG0313
246195002081	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
246195002082	putative SAM binding site [chemical binding]; other site
246195002083	putative homodimer interface [polypeptide binding]; other site
246195002084	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
246195002085	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
246195002086	ABC-ATPase subunit  interface; other site
246195002087	dimer interface [polypeptide binding]; other site
246195002088	putative PBP binding regions; other site
246195002089	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
246195002090	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
246195002091	ABC-ATPase subunit  interface; other site
246195002092	dimer interface [polypeptide binding]; other site
246195002093	putative PBP binding regions; other site
246195002094	manganese/iron transporter ATP-binding protein; Provisional; Region: PRK15056
246195002095	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
246195002096	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
246195002097	Metal binding protein PsaA.  These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137
246195002098	metal binding site [ion binding]; metal-binding site
246195002099	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
246195002100	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
246195002101	catalytic site [active]
246195002102	G-X2-G-X-G-K; other site
246195002103	Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147
246195002104	chorismate binding enzyme; Region: Chorismate_bind; cl10555
246195002105	ADCL_like: 4-Amino-4-deoxychorismate lyase:  is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate.  Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559
246195002106	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
246195002107	pyridoxal 5'-phosphate binding site [chemical binding]; other site
246195002108	catalytic residue [active]
246195002109	A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
246195002110	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
246195002111	minor groove reading motif; other site
246195002112	helix-hairpin-helix signature motif; other site
246195002113	substrate binding pocket [chemical binding]; other site
246195002114	active site
246195002115	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304
246195002116	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
246195002117	DNA binding and oxoG recognition site [nucleotide binding]
246195002118	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
246195002119	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
246195002120	substrate binding pocket [chemical binding]; other site
246195002121	chain length determination region; other site
246195002122	substrate-Mg2+ binding site; other site
246195002123	catalytic residues [active]
246195002124	aspartate-rich region 1; other site
246195002125	active site lid residues [active]
246195002126	aspartate-rich region 2; other site
246195002127	ribosome small subunit-dependent GTPase A; Region: TIGR00157
246195002128	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
246195002129	GTPase/Zn-binding domain interface [polypeptide binding]; other site
246195002130	GTP/Mg2+ binding site [chemical binding]; other site
246195002131	G4 box; other site
246195002132	G5 box; other site
246195002133	G1 box; other site
246195002134	Switch I region; other site
246195002135	G2 box; other site
246195002136	G3 box; other site
246195002137	Switch II region; other site
246195002138	VacJ like lipoprotein; Region: VacJ; cl01073
246195002139	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
246195002140	Domain of unknown function DUF20; Region: UPF0118; pfam01594
246195002141	Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890
246195002142	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
246195002143	S-adenosylmethionine binding site [chemical binding]; other site
246195002144	Peptidase C26; Region: Peptidase_C26; pfam07722
246195002145	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
246195002146	catalytic triad [active]
246195002147	Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757
246195002148	ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639
246195002149	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
246195002150	Walker A motif; other site
246195002151	ATP binding site [chemical binding]; other site
246195002152	Walker B motif; other site
246195002153	arginine finger; other site
246195002154	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
246195002155	Walker A motif; other site
246195002156	ATP binding site [chemical binding]; other site
246195002157	Walker B motif; other site
246195002158	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
246195002159	ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; pfam02617
246195002160	Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294
246195002161	active site
246195002162	substrate binding pocket [chemical binding]; other site
246195002163	dimer interface [polypeptide binding]; other site
246195002164	Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671
246195002165	putative active site [active]
246195002166	Ap4A binding site [chemical binding]; other site
246195002167	nudix motif; other site
246195002168	putative metal binding site [ion binding]; other site
246195002169	Cation efflux family; Region: Cation_efflux; cl00316
246195002170	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
246195002171	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
246195002172	S-adenosylmethionine binding site [chemical binding]; other site
246195002173	Permease family; Region: Xan_ur_permease; pfam00860
246195002174	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
246195002175	active site
246195002176	dimerization interface [polypeptide binding]; other site
246195002177	ribonuclease PH; Reviewed; Region: rph; PRK00173
246195002178	Ribonuclease PH; Region: RNase_PH_bact; cd11362
246195002179	hexamer interface [polypeptide binding]; other site
246195002180	active site
246195002181	hypothetical protein; Provisional; Region: PRK11820
246195002182	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
246195002183	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
246195002184	Disulfide bond formation protein DsbB; Region: DsbB; pfam02600
246195002185	adenylosuccinate lyase; Provisional; Region: PRK09285
246195002186	PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598
246195002187	tetramer interface [polypeptide binding]; other site
246195002188	active site
246195002189	Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971
246195002190	tetramer interfaces [polypeptide binding]; other site
246195002191	binuclear metal-binding site [ion binding]; other site
246195002192	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
246195002193	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
246195002194	quinone interaction residues [chemical binding]; other site
246195002195	active site
246195002196	catalytic residues [active]
246195002197	FMN binding site [chemical binding]; other site
246195002198	substrate binding site [chemical binding]; other site
246195002199	3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355
246195002200	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
246195002201	catalytic residue [active]
246195002202	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
246195002203	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
246195002204	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
246195002205	YGGT family; Region: YGGT; pfam02325
246195002206	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
246195002207	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
246195002208	Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805
246195002209	Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131
246195002210	Walker A motif; other site
246195002211	ATP binding site [chemical binding]; other site
246195002212	Walker B motif; other site
246195002213	Tfp pilus assembly protein, ATPase PilU [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilU; COG5008
246195002214	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
246195002215	Walker A motif; other site
246195002216	ATP binding site [chemical binding]; other site
246195002217	Walker B motif; other site
246195002218	DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559
246195002219	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
246195002220	ATP binding site [chemical binding]; other site
246195002221	Mg2+ binding site [ion binding]; other site
246195002222	G-X-G motif; other site
246195002223	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
246195002224	anchoring element; other site
246195002225	dimer interface [polypeptide binding]; other site
246195002226	ATP binding site [chemical binding]; other site
246195002227	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
246195002228	active site
246195002229	metal binding site [ion binding]; metal-binding site
246195002230	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
246195002231	DNA topoisomerase IV subunit A; Validated; Region: PRK05561
246195002232	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
246195002233	CAP-like domain; other site
246195002234	active site
246195002235	primary dimer interface [polypeptide binding]; other site
246195002236	Choline/Carnitine o-acyltransferase; Region: Carn_acyltransf; pfam00755
246195002237	leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301
246195002238	outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303
246195002239	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
246195002240	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
246195002241	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
246195002242	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
246195002243	Surface antigen; Region: Bac_surface_Ag; pfam01103
246195002244	Outer membrane protein (OmpH-like); Region: OmpH; pfam03938
246195002245	periplasmic chaperone; Provisional; Region: PRK10780
246195002246	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Region: lipid_A_lpxD; TIGR01853
246195002247	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
246195002248	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
246195002249	trimer interface [polypeptide binding]; other site
246195002250	putative trimer interface [polypeptide binding]; other site
246195002251	putative CoA binding site [chemical binding]; other site
246195002252	active site
246195002253	UDP-GlcNAc binding site [chemical binding]; other site
246195002254	lipid binding site [chemical binding]; lipid-binding site
246195002255	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
246195002256	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
246195002257	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
246195002258	active site
246195002259	lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025
246195002260	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
246195002261	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
246195002262	RNA/DNA hybrid binding site [nucleotide binding]; other site
246195002263	active site
246195002264	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
246195002265	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433
246195002266	putative active site [active]
246195002267	putative PHP Thumb interface [polypeptide binding]; other site
246195002268	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
246195002269	generic binding surface I; other site
246195002270	generic binding surface II; other site
246195002271	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
246195002272	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
246195002273	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
246195002274	ATP binding site [chemical binding]; other site
246195002275	putative Mg++ binding site [ion binding]; other site
246195002276	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
246195002277	nucleotide binding region [chemical binding]; other site
246195002278	ATP-binding site [chemical binding]; other site
246195002279	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
246195002280	Herpesvirus ICP4-like protein N-terminal region; Region: Herpes_ICP4_N; cl17480
246195002281	Herpesvirus latent membrane protein 1 (LMP1); Region: Herpes_LMP1; pfam05297
246195002282	Herpesvirus latent membrane protein 1 (LMP1); Region: Herpes_LMP1; pfam05297
246195002283	GTPase Era; Reviewed; Region: era; PRK00089
246195002284	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
246195002285	G1 box; other site
246195002286	GTP/Mg2+ binding site [chemical binding]; other site
246195002287	Switch I region; other site
246195002288	G2 box; other site
246195002289	Switch II region; other site
246195002290	G3 box; other site
246195002291	G4 box; other site
246195002292	G5 box; other site
246195002293	KH domain; Region: KH_2; pfam07650
246195002294	ribonuclease III; Reviewed; Region: rnc; PRK00102
246195002295	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
246195002296	dimerization interface [polypeptide binding]; other site
246195002297	active site
246195002298	metal binding site [ion binding]; metal-binding site
246195002299	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
246195002300	dsRNA binding site [nucleotide binding]; other site
246195002301	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
246195002302	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
246195002303	Catalytic site [active]
246195002304	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
246195002305	GTP-binding protein LepA; Provisional; Region: PRK05433
246195002306	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
246195002307	G1 box; other site
246195002308	putative GEF interaction site [polypeptide binding]; other site
246195002309	GTP/Mg2+ binding site [chemical binding]; other site
246195002310	Switch I region; other site
246195002311	G2 box; other site
246195002312	G3 box; other site
246195002313	Switch II region; other site
246195002314	G4 box; other site
246195002315	G5 box; other site
246195002316	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
246195002317	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
246195002318	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
246195002319	Nucleoside recognition; Region: Gate; pfam07670
246195002320	hypothetical protein; Provisional; Region: PRK10519
246195002321	M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885
246195002322	glutamate carboxypeptidase; Reviewed; Region: PRK06133
246195002323	metal binding site [ion binding]; metal-binding site
246195002324	dimer interface [polypeptide binding]; other site
246195002325	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
246195002326	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
246195002327	Sulfate transporter family; Region: Sulfate_transp; pfam00916
246195002328	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
246195002329	NlpE N-terminal domain; Region: NlpE; pfam04170
246195002330	purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819
246195002331	Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820
246195002332	glycyl-tRNA synthetase subunit alpha; Validated; Region: glyQ; PRK09348
246195002333	motif 1; other site
246195002334	dimer interface [polypeptide binding]; other site
246195002335	active site
246195002336	motif 2; other site
246195002337	motif 3; other site
246195002338	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
246195002339	DALR anticodon binding domain; Region: DALR_1; pfam05746
246195002340	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025
246195002341	active pocket/dimerization site; other site
246195002342	active site
246195002343	phosphorylation site [posttranslational modification]
246195002344	Domain of unknown function (DUF386); Region: DUF386; cl01047
246195002345	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
246195002346	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
246195002347	nucleotide binding site [chemical binding]; other site
246195002348	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
246195002349	catalytic core [active]
246195002350	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
246195002351	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
246195002352	metal binding site 2 [ion binding]; metal-binding site
246195002353	putative DNA binding helix; other site
246195002354	metal binding site 1 [ion binding]; metal-binding site
246195002355	dimer interface [polypeptide binding]; other site
246195002356	structural Zn2+ binding site [ion binding]; other site
246195002357	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
246195002358	1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080
246195002359	UbiA prenyltransferase family; Region: UbiA; pfam01040
246195002360	Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704
246195002361	anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412
246195002362	similar to tRNA pseudouridine synthase A; identified by match to protein family HMM PF01416; match to protein family HMM TIGR00071
246195002363	FimV N-terminal domain; Region: FimV_core; TIGR03505
246195002364	FimV C-terminal domain; Region: FimV_Cterm; TIGR03504
246195002365	Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230
246195002366	putative hydrolase; Provisional; Region: PRK11460
246195002367	Cell division protein ZapA; Region: ZapA; pfam05164
246195002368	Uncharacterized protein family (UPF0149); Region: UPF0149; pfam03695
246195002369	zinc metallopeptidase RseP; Provisional; Region: PRK10779
246195002370	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
246195002371	active site
246195002372	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
246195002373	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
246195002374	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
246195002375	putative substrate binding region [chemical binding]; other site
246195002376	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
246195002377	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
246195002378	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
246195002379	Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255
246195002380	catalytic residue [active]
246195002381	putative FPP diphosphate  binding site; other site
246195002382	putative FPP binding hydrophobic cleft; other site
246195002383	dimer interface [polypeptide binding]; other site
246195002384	putative IPP diphosphate binding site; other site
246195002385	ribosome recycling factor; Reviewed; Region: frr; PRK00083
246195002386	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
246195002387	hinge region; other site
246195002388	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
246195002389	putative nucleotide binding site [chemical binding]; other site
246195002390	uridine monophosphate binding site [chemical binding]; other site
246195002391	homohexameric interface [polypeptide binding]; other site
246195002392	elongation factor Ts; Provisional; Region: tsf; PRK09377
246195002393	UBA/TS-N domain; Region: UBA; pfam00627
246195002394	Elongation factor TS; Region: EF_TS; pfam00889
246195002395	Elongation factor TS; Region: EF_TS; pfam00889
246195002396	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
246195002397	rRNA interaction site [nucleotide binding]; other site
246195002398	S8 interaction site; other site
246195002399	putative laminin-1 binding site; other site
246195002400	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
246195002401	active site
246195002402	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
246195002403	active site
246195002404	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
246195002405	ABC transporter ATPase component; Reviewed; Region: PRK11147
246195002406	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
246195002407	Walker A/P-loop; other site
246195002408	ATP binding site [chemical binding]; other site
246195002409	Q-loop/lid; other site
246195002410	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
246195002411	ABC transporter signature motif; other site
246195002412	Walker B; other site
246195002413	D-loop; other site
246195002414	ABC transporter; Region: ABC_tran_2; pfam12848
246195002415	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
246195002416	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
246195002417	glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710
246195002418	active site
246195002419	HIGH motif; other site
246195002420	nucleotide binding site [chemical binding]; other site
246195002421	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
246195002422	active site
246195002423	KMSKS motif; other site
246195002424	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
246195002425	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
246195002426	dimer interface [polypeptide binding]; other site
246195002427	active site
246195002428	metal binding site [ion binding]; metal-binding site
246195002429	glutathione binding site [chemical binding]; other site
246195002430	transcription termination factor Rho; Provisional; Region: rho; PRK09376
246195002431	Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498
246195002432	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
246195002433	RNA binding site [nucleotide binding]; other site
246195002434	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
246195002435	multimer interface [polypeptide binding]; other site
246195002436	Walker A motif; other site
246195002437	ATP binding site [chemical binding]; other site
246195002438	Walker B motif; other site
246195002439	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
246195002440	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
246195002441	catalytic residues [active]
246195002442	Lysozyme family protein [General function prediction only]; Region: zliS; COG3926
246195002443	Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838
246195002444	Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374
246195002445	Phage terminase large subunit; Region: Terminase_3; cl12054
246195002446	Phage Mu protein F like protein; Region: Phage_Mu_F; pfam04233
246195002447	Phage major capsid protein E; Region: Phage_cap_E; pfam03864
246195002448	Protein of unknown function (DUF1320); Region: DUF1320; pfam07030
246195002449	Phage virion morphogenesis family; Region: Phage_tail_S; cl02089
246195002450	HeH/LEM domain; Region: HeH; pfam12949
246195002451	phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760
246195002452	DNA methylase; Region: N6_N4_Mtase; cl17433
246195002453	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
246195002454	ATP binding site [chemical binding]; other site
246195002455	putative Mg++ binding site [ion binding]; other site
246195002456	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
246195002457	nucleotide binding region [chemical binding]; other site
246195002458	ATP-binding site [chemical binding]; other site
246195002459	Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523
246195002460	Asp23 family; Region: Asp23; cl00574
246195002461	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
246195002462	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
246195002463	dimer interface [polypeptide binding]; other site
246195002464	ssDNA binding site [nucleotide binding]; other site
246195002465	tetramer (dimer of dimers) interface [polypeptide binding]; other site
246195002466	YqaJ-like viral recombinase domain; Region: YqaJ; pfam09588
246195002467	ERF superfamily; Region: ERF; pfam04404
246195002468	Domain of unknown function (DUF4041); Region: DUF4041; pfam13250
246195002469	This entry represents the putative helicase A859L; Region: T5orf172; smart00974
246195002470	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
246195002471	non-specific DNA binding site [nucleotide binding]; other site
246195002472	Predicted transcriptional regulator [Transcription]; Region: COG2932
246195002473	salt bridge; other site
246195002474	sequence-specific DNA binding site [nucleotide binding]; other site
246195002475	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
246195002476	Catalytic site [active]
246195002477	Helix-turn-helix domain; Region: HTH_39; pfam14090
246195002478	Helix-turn-helix domain; Region: HTH_36; pfam13730
246195002479	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
246195002480	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
246195002481	Walker A motif; other site
246195002482	ATP binding site [chemical binding]; other site
246195002483	Walker B motif; other site
246195002484	arginine finger; other site
246195002485	Endodeoxyribonuclease RusA; Region: RusA; pfam05866
246195002486	Predicted ATPase [General function prediction only]; Region: COG5293
246195002487	integrase; Provisional; Region: PRK09692
246195002488	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
246195002489	active site
246195002490	Int/Topo IB signature motif; other site
246195002491	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
246195002492	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
246195002493	OsmC-like protein; Region: OsmC; cl00767
246195002494	multidrug efflux protein; Reviewed; Region: PRK01766
246195002495	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131
246195002496	cation binding site [ion binding]; other site
246195002497	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
246195002498	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
246195002499	folate binding site [chemical binding]; other site
246195002500	NADP+ binding site [chemical binding]; other site
246195002501	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
246195002502	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
246195002503	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
246195002504	O-Antigen ligase; Region: Wzy_C; pfam04932
246195002505	Peptide methionine sulfoxide reductase; Region: PMSR; cl00366
246195002506	Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229; cl15841
246195002507	SelR domain; Region: SelR; pfam01641
246195002508	Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704
246195002509	Peptidase family M48; Region: Peptidase_M48; cl12018
246195002510	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
246195002511	MgtE intracellular N domain; Region: MgtE_N; smart00924
246195002512	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
246195002513	Divalent cation transporter; Region: MgtE; cl00786
246195002514	Hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase; cl00205
246195002515	homodimer interface [polypeptide binding]; other site
246195002516	substrate binding pocket [chemical binding]; other site
246195002517	catalytic residues [active]
246195002518	NADH/NADPH cofactor binding site [chemical binding]; other site
246195002519	isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437
246195002520	Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811
246195002521	homotetramer interface [polypeptide binding]; other site
246195002522	FMN binding site [chemical binding]; other site
246195002523	homodimer contacts [polypeptide binding]; other site
246195002524	putative active site [active]
246195002525	putative substrate binding site [chemical binding]; other site
246195002526	3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835
246195002527	"initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827
246195002528	dimer interface [polypeptide binding]; other site
246195002529	active site
246195002530	mevalonate kinase; Region: mevalon_kin; TIGR00549
246195002531	Uncharacterized conserved protein [Function unknown]; Region: COG2128
246195002532	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
246195002533	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
246195002534	active site
246195002535	nucleophile elbow; other site
246195002536	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
246195002537	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
246195002538	active site
246195002539	dimerization interface [polypeptide binding]; other site
246195002540	Protein of unknown function (DUF539); Region: DUF539; cl01129
246195002541	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
246195002542	ApbE family; Region: ApbE; pfam02424
246195002543	Na(+)-translocating NADH-quinone reductase subunit F; Provisional; Region: PRK05464
246195002544	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
246195002545	catalytic loop [active]
246195002546	iron binding site [ion binding]; other site
246195002547	Na+-translocating NADH:quinone oxidoreductase (Na+-NQR) FAD/NADH binding domain. (Na+-NQR) provides a means of storing redox reaction energy via the transmembrane translocation of Na2+ ions. The C-terminal domain resembles ferredoxin:NADP+ oxidoreductase; Region: NADH_quinone_reductase; cd06188
246195002548	FAD binding pocket [chemical binding]; other site
246195002549	FAD binding motif [chemical binding]; other site
246195002550	phosphate binding motif [ion binding]; other site
246195002551	beta-alpha-beta structure motif; other site
246195002552	NAD binding pocket [chemical binding]; other site
246195002553	Na(+)-translocating NADH-quinone reductase subunit E; Provisional; Region: PRK02830
246195002554	Na(+)-translocating NADH-quinone reductase subunit D; Validated; Region: PRK09292
246195002555	Na(+)-translocating NADH-quinone reductase subunit C; Provisional; Region: PRK05346
246195002556	NADH:ubiquinone oxidoreductase, Na(+)-translocating, C subunit; Region: nqrC; TIGR01938
246195002557	Na(+)-translocating NADH-quinone reductase subunit B; Provisional; Region: PRK05349
246195002558	Na(+)-translocating NADH-quinone reductase subunit A; Provisional; Region: PRK05352
246195002559	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
246195002560	E3 interaction surface; other site
246195002561	lipoyl attachment site [posttranslational modification]; other site
246195002562	NQRA C-terminal domain; Region: NQRA_SLBB; pfam11973
246195002563	Preprotein translocase SecG subunit; Region: SecG; pfam03840
246195002564	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
246195002565	triosephosphate isomerase; Provisional; Region: PRK14565
246195002566	substrate binding site [chemical binding]; other site
246195002567	dimer interface [polypeptide binding]; other site
246195002568	catalytic triad [active]
246195002569	phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887
246195002570	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
246195002571	active site
246195002572	substrate binding site [chemical binding]; other site
246195002573	metal binding site [ion binding]; metal-binding site
246195002574	Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133
246195002575	2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830
246195002576	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
246195002577	active site
246195002578	substrate binding site [chemical binding]; other site
246195002579	trimer interface [polypeptide binding]; other site
246195002580	CoA binding site [chemical binding]; other site
246195002581	7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258
246195002582	hypothetical protein; Provisional; Region: PRK11212
246195002583	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
246195002584	PAS domain; Region: PAS; smart00091
246195002585	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
246195002586	dimer interface [polypeptide binding]; other site
246195002587	phosphorylation site [posttranslational modification]
246195002588	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
246195002589	ATP binding site [chemical binding]; other site
246195002590	Mg2+ binding site [ion binding]; other site
246195002591	G-X-G motif; other site
246195002592	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
246195002593	Response regulator receiver domain; Region: Response_reg; pfam00072
246195002594	active site
246195002595	phosphorylation site [posttranslational modification]
246195002596	intermolecular recognition site; other site
246195002597	dimerization interface [polypeptide binding]; other site
246195002598	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
246195002599	Response regulator receiver domain; Region: Response_reg; pfam00072
246195002600	active site
246195002601	phosphorylation site [posttranslational modification]
246195002602	intermolecular recognition site; other site
246195002603	dimerization interface [polypeptide binding]; other site
246195002604	hypothetical protein; Reviewed; Region: PRK00024
246195002605	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
246195002606	MPN+ (JAMM) motif; other site
246195002607	Zinc-binding site [ion binding]; other site
246195002608	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
246195002609	Flavoprotein; Region: Flavoprotein; pfam02441
246195002610	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
246195002611	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
246195002612	trimer interface [polypeptide binding]; other site
246195002613	active site
246195002614	GrpE; Region: GrpE; pfam01025
246195002615	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
246195002616	dimer interface [polypeptide binding]; other site
246195002617	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
246195002618	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
246195002619	Nucleotide-binding domain of human HSPA9, Escherichia coli DnaK, and similar proteins; Region: HSPA9-like_NBD; cd11733
246195002620	nucleotide binding site [chemical binding]; other site
246195002621	NEF interaction site [polypeptide binding]; other site
246195002622	SBD interface [polypeptide binding]; other site
246195002623	chaperone protein DnaJ; Provisional; Region: PRK10767
246195002624	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
246195002625	HSP70 interaction site [polypeptide binding]; other site
246195002626	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
246195002627	substrate binding site [polypeptide binding]; other site
246195002628	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
246195002629	Zn binding sites [ion binding]; other site
246195002630	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
246195002631	dimer interface [polypeptide binding]; other site
246195002632	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
246195002633	Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548
246195002634	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
246195002635	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
246195002636	active site
246195002637	catalytic tetrad [active]
246195002638	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
246195002639	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
246195002640	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
246195002641	substrate binding pocket [chemical binding]; other site
246195002642	membrane-bound complex binding site; other site
246195002643	hinge residues; other site
246195002644	FeS assembly SUF system protein; Region: SUF_assoc; TIGR02945
246195002645	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
246195002646	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
246195002647	trimerization site [polypeptide binding]; other site
246195002648	active site
246195002649	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
246195002650	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
246195002651	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
246195002652	catalytic residue [active]
246195002653	FeS assembly protein SufD; Region: sufD; TIGR01981
246195002654	Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458
246195002655	FeS assembly ATPase SufC; Region: sufC; TIGR01978
246195002656	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
246195002657	Walker A/P-loop; other site
246195002658	ATP binding site [chemical binding]; other site
246195002659	Q-loop/lid; other site
246195002660	ABC transporter signature motif; other site
246195002661	Walker B; other site
246195002662	D-loop; other site
246195002663	H-loop/switch region; other site
246195002664	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814
246195002665	putative ABC transporter; Region: ycf24; CHL00085
246195002666	FeS assembly SUF system regulator, gammaproteobacterial; Region: suf_reg_Xantho; TIGR02944
246195002667	Transcriptional regulator; Region: Rrf2; pfam02082
246195002668	Transcriptional regulator; Region: Rrf2; cl17282
246195002669	Domain of unknown function (DUF3488); Region: DUF3488; pfam11992
246195002670	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
246195002671	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
246195002672	Protein of unknown function DUF58; Region: DUF58; pfam01882
246195002673	MoxR-like ATPases [General function prediction only]; Region: COG0714
246195002674	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
246195002675	tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652
246195002676	Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663
246195002677	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
246195002678	nudix motif; other site
246195002679	conserved hypothetical protein; Region: TIGR02231
246195002680	N-terminal domain of unknown function (DUF4140); Region: DUF4140; pfam13600
246195002681	Domain of unknown function (DUF4139); Region: DUF4139; pfam13598
246195002682	Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162
246195002683	glycerate dehydrogenase; Provisional; Region: PRK06487
246195002684	putative ligand binding site [chemical binding]; other site
246195002685	putative NAD binding site [chemical binding]; other site
246195002686	catalytic site [active]
246195002687	MarC family integral membrane protein; Region: MarC; cl00919
246195002688	Stringent starvation protein B; Region: SspB; cl01120
246195002689	stringent starvation protein A; Provisional; Region: sspA; PRK09481
246195002690	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
246195002691	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
246195002692	N-terminal domain interface [polypeptide binding]; other site
246195002693	dimer interface [polypeptide binding]; other site
246195002694	substrate binding pocket (H-site) [chemical binding]; other site
246195002695	Uncharacterized conserved protein [Function unknown]; Region: COG0327
246195002696	NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371
246195002697	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
246195002698	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
246195002699	hinge; other site
246195002700	active site
246195002701	BolA-like protein; Region: BolA; cl00386
246195002702	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
246195002703	anti sigma factor interaction site; other site
246195002704	regulatory phosphorylation site [posttranslational modification]; other site
246195002705	Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494
246195002706	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
246195002707	mce related protein; Region: MCE; pfam02470
246195002708	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
246195002709	mce related protein; Region: MCE; pfam02470
246195002710	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
246195002711	Permease; Region: Permease; pfam02405
246195002712	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
246195002713	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
246195002714	Walker A/P-loop; other site
246195002715	ATP binding site [chemical binding]; other site
246195002716	Q-loop/lid; other site
246195002717	ABC transporter signature motif; other site
246195002718	Walker B; other site
246195002719	D-loop; other site
246195002720	H-loop/switch region; other site
246195002721	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911
246195002722	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
246195002723	Family of unknown function (DUF490); Region: DUF490; pfam04357
246195002724	Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729
246195002725	Surface antigen; Region: Bac_surface_Ag; pfam01103
246195002726	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
246195002727	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
246195002728	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
246195002729	FAD binding site [chemical binding]; other site
246195002730	ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837
246195002731	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
246195002732	ATP binding site [chemical binding]; other site
246195002733	Mg++ binding site [ion binding]; other site
246195002734	motif III; other site
246195002735	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
246195002736	nucleotide binding region [chemical binding]; other site
246195002737	ATP-binding site [chemical binding]; other site
246195002738	NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149
246195002739	dimer interface [polypeptide binding]; other site
246195002740	FMN binding site [chemical binding]; other site
246195002741	Chemotaxis phosphatase CheX; Region: CheX; pfam13690
246195002742	Response regulator receiver domain; Region: Response_reg; pfam00072
246195002743	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
246195002744	active site
246195002745	phosphorylation site [posttranslational modification]
246195002746	intermolecular recognition site; other site
246195002747	dimerization interface [polypeptide binding]; other site
246195002748	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
246195002749	putative binding surface; other site
246195002750	active site
246195002751	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
246195002752	ATP binding site [chemical binding]; other site
246195002753	Mg2+ binding site [ion binding]; other site
246195002754	G-X-G motif; other site
246195002755	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
246195002756	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
246195002757	putative metal binding site; other site
246195002758	macrolide transporter subunit MacA; Provisional; Region: PRK11578
246195002759	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
246195002760	HlyD family secretion protein; Region: HlyD_3; pfam13437
246195002761	macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535
246195002762	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
246195002763	Walker A/P-loop; other site
246195002764	ATP binding site [chemical binding]; other site
246195002765	Q-loop/lid; other site
246195002766	ABC transporter signature motif; other site
246195002767	Walker B; other site
246195002768	D-loop; other site
246195002769	H-loop/switch region; other site
246195002770	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
246195002771	FtsX-like permease family; Region: FtsX; pfam02687
246195002772	outer membrane lipoprotein; Provisional; Region: PRK11023
246195002773	BON domain; Region: BON; cl02771
246195002774	BON domain; Region: BON; pfam04972
246195002775	aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273
246195002776	Aspartase; Region: Aspartase; cd01357
246195002777	active sites [active]
246195002778	tetramer interface [polypeptide binding]; other site
246195002779	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
246195002780	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
246195002781	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
246195002782	P loop; other site
246195002783	GTP binding site [chemical binding]; other site
246195002784	RNA polymerase factor sigma-32; Reviewed; Region: PRK06596
246195002785	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
246195002786	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
246195002787	DNA binding residues [nucleotide binding]
246195002788	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
246195002789	metal binding site 2 [ion binding]; metal-binding site
246195002790	putative DNA binding helix; other site
246195002791	metal binding site 1 [ion binding]; metal-binding site
246195002792	dimer interface [polypeptide binding]; other site
246195002793	structural Zn2+ binding site [ion binding]; other site
246195002794	Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483
246195002795	catalytic motif [active]
246195002796	Catalytic residue [active]
246195002797	Protein of unknown function (DUF533); Region: DUF533; pfam04391
246195002798	tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178
246195002799	putative metal binding site [ion binding]; other site
246195002800	Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226
246195002801	Domain of unknown function (DUF4198); Region: DUF4198; pfam10670
246195002802	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
246195002803	Helix-hairpin-helix motif; Region: HHH; pfam00633
246195002804	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
246195002805	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
246195002806	putative active site [active]
246195002807	Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019
246195002808	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
246195002809	metal binding site [ion binding]; metal-binding site
246195002810	Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968
246195002811	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
246195002812	Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimT; COG4970
246195002813	Type II transport protein GspH; Region: GspH; pfam12019
246195002814	Tfp pilus assembly protein PilW [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilW; COG4966
246195002815	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
246195002816	type IV pilus modification protein PilV; Region: type_IV_pilV; TIGR02523
246195002817	Neisseria PilC beta-propeller domain; Region: Neisseria_PilC; pfam05567
246195002818	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
246195002819	Protein of unknown function (DUF493); Region: DUF493; pfam04359
246195002820	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
246195002821	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
246195002822	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936
246195002823	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
246195002824	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
246195002825	dimerization interface [polypeptide binding]; other site
246195002826	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
246195002827	dimer interface [polypeptide binding]; other site
246195002828	phosphorylation site [posttranslational modification]
246195002829	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
246195002830	ATP binding site [chemical binding]; other site
246195002831	Mg2+ binding site [ion binding]; other site
246195002832	G-X-G motif; other site
246195002833	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
246195002834	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
246195002835	active site
246195002836	phosphorylation site [posttranslational modification]
246195002837	intermolecular recognition site; other site
246195002838	dimerization interface [polypeptide binding]; other site
246195002839	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
246195002840	DNA binding site [nucleotide binding]
246195002841	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
246195002842	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
246195002843	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
246195002844	protein binding site [polypeptide binding]; other site
246195002845	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
246195002846	protein binding site [polypeptide binding]; other site
246195002847	phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154
246195002848	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
246195002849	active site
246195002850	phosphorylation site [posttranslational modification]
246195002851	intermolecular recognition site; other site
246195002852	dimerization interface [polypeptide binding]; other site
246195002853	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
246195002854	DNA binding site [nucleotide binding]
246195002855	DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135
246195002856	catalytic site [active]
246195002857	putative active site [active]
246195002858	putative substrate binding site [chemical binding]; other site
246195002859	dimer interface [polypeptide binding]; other site
246195002860	holo-(acyl carrier protein) synthase 2; Provisional; Region: PRK10351
246195002861	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
246195002862	DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406
246195002863	DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131
246195002864	active site
246195002865	catalytic site [active]
246195002866	substrate binding site [chemical binding]; other site
246195002867	phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150
246195002868	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799
246195002869	active site
246195002870	substrate binding site [chemical binding]; other site
246195002871	metal binding site [ion binding]; metal-binding site
246195002872	thymidine phosphorylase; Reviewed; Region: deoA; PRK05820
246195002873	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
246195002874	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
246195002875	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941
246195002876	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
246195002877	intersubunit interface [polypeptide binding]; other site
246195002878	active site
246195002879	catalytic residue [active]
246195002880	anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK08271
246195002881	Class III ribonucleotide reductase; Region: RNR_III; cd01675
246195002882	effector binding site; other site
246195002883	active site
246195002884	Zn binding site [ion binding]; other site
246195002885	glycine loop; other site
246195002886	anaerobic ribonucleoside-triphosphate reductase activating protein; Region: RNR_activ_nrdG3; TIGR02826
246195002887	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
246195002888	RNA binding surface [nucleotide binding]; other site
246195002889	Septum formation topological specificity factor MinE; Region: MinE; cl00538
246195002890	Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894
246195002891	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
246195002892	Switch I; other site
246195002893	Switch II; other site
246195002894	Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209
246195002895	septum formation inhibitor; Reviewed; Region: minC; PRK00339
246195002896	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
246195002897	SurA N-terminal domain; Region: SurA_N_3; cl07813
246195002898	Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281
246195002899	putative active site [active]
246195002900	putative catalytic site [active]
246195002901	putative DNA binding site [nucleotide binding]; other site
246195002902	putative phosphate binding site [ion binding]; other site
246195002903	metal binding site A [ion binding]; metal-binding site
246195002904	putative AP binding site [nucleotide binding]; other site
246195002905	putative metal binding site B [ion binding]; other site
246195002906	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
246195002907	active site
246195002908	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
246195002909	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
246195002910	purine monophosphate binding site [chemical binding]; other site
246195002911	dimer interface [polypeptide binding]; other site
246195002912	putative catalytic residues [active]
246195002913	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
246195002914	Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452
246195002915	Organic solvent tolerance protein; Region: OstA_C; pfam04453
246195002916	SurA N-terminal domain; Region: SurA_N; pfam09312
246195002917	PPIC-type PPIASE domain; Region: Rotamase_2; cl08278
246195002918	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
246195002919	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
246195002920	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
246195002921	S-adenosylmethionine binding site [chemical binding]; other site
246195002922	short chain dehydrogenase; Provisional; Region: PRK07023
246195002923	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
246195002924	NAD(P) binding site [chemical binding]; other site
246195002925	active site
246195002926	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
246195002927	DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020
246195002928	dimerization domain [polypeptide binding]; other site
246195002929	dimer interface [polypeptide binding]; other site
246195002930	catalytic residues [active]
246195002931	Aquifex aeolicus AQ1575 and related proteins, metallophosphatase domain; Region: MPP_AQ1575; cd07390
246195002932	putative active site [active]
246195002933	putative metal binding site [ion binding]; other site
246195002934	Chorismate mutase type II; Region: CM_2; cl00693
246195002935	Predicted metalloprotease [General function prediction only]; Region: COG2321
246195002936	Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228
246195002937	Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate  (PLP), by catalyzing the phosphorylation of the precursor vitamin B6  in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173
246195002938	dimer interface [polypeptide binding]; other site
246195002939	pyridoxamine kinase; Validated; Region: PRK05756
246195002940	pyridoxal binding site [chemical binding]; other site
246195002941	ATP binding site [chemical binding]; other site
246195002942	Domain of unknown function (DUF1974); Region: DUF1974; pfam09317
246195002943	Predicted membrane protein [Function unknown]; Region: COG1288
246195002944	C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606
246195002945	4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170
246195002946	substrate binding site [chemical binding]; other site
246195002947	multimerization interface [polypeptide binding]; other site
246195002948	ATP binding site [chemical binding]; other site
246195002949	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
246195002950	Coenzyme A binding pocket [chemical binding]; other site
246195002951	methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133
246195002952	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
246195002953	active site
246195002954	HIGH motif; other site
246195002955	KMSKS motif; other site
246195002956	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
246195002957	tRNA binding surface [nucleotide binding]; other site
246195002958	anticodon binding site; other site
246195002959	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
246195002960	dimer interface [polypeptide binding]; other site
246195002961	putative tRNA-binding site [nucleotide binding]; other site
246195002962	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
246195002963	FOG: CBS domain [General function prediction only]; Region: COG0517
246195002964	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
246195002965	Transporter associated domain; Region: CorC_HlyC; smart01091
246195002966	L,D-transpeptidase; Provisional; Region: PRK10190
246195002967	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
246195002968	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
246195002969	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
246195002970	dimer interface [polypeptide binding]; other site
246195002971	putative anticodon binding site; other site
246195002972	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
246195002973	motif 1; other site
246195002974	active site
246195002975	motif 2; other site
246195002976	motif 3; other site
246195002977	peptide chain release factor 2; Provisional; Region: PRK08787
246195002978	This domain is found in peptide chain release factors; Region: PCRF; smart00937
246195002979	RF-1 domain; Region: RF-1; pfam00472
246195002980	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
246195002981	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
246195002982	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
246195002983	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
246195002984	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
246195002985	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
246195002986	NAD binding site [chemical binding]; other site
246195002987	homodimer interface [polypeptide binding]; other site
246195002988	active site
246195002989	substrate binding site [chemical binding]; other site
246195002990	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578
246195002991	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
246195002992	Peptidase family C69; Region: Peptidase_C69; cl17793
246195002993	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
246195002994	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
246195002995	substrate binding pocket [chemical binding]; other site
246195002996	chain length determination region; other site
246195002997	substrate-Mg2+ binding site; other site
246195002998	catalytic residues [active]
246195002999	aspartate-rich region 1; other site
246195003000	active site lid residues [active]
246195003001	aspartate-rich region 2; other site
246195003002	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
246195003003	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
246195003004	trmE is a tRNA modification GTPase; Region: trmE; cd04164
246195003005	G1 box; other site
246195003006	GTP/Mg2+ binding site [chemical binding]; other site
246195003007	Switch I region; other site
246195003008	G2 box; other site
246195003009	Switch II region; other site
246195003010	G3 box; other site
246195003011	G4 box; other site
246195003012	G5 box; other site
246195003013	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
246195003014	membrane protein insertase; Provisional; Region: PRK01318
246195003015	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
246195003016	Haemolytic domain; Region: Haemolytic; pfam01809
246195003017	Ribonuclease P; Region: Ribonuclease_P; pfam00825
246195003018	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399
246195003019	recombination protein RecR; Reviewed; Region: recR; PRK00076
246195003020	RecR protein; Region: RecR; pfam02132
246195003021	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
246195003022	putative active site [active]
246195003023	putative metal-binding site [ion binding]; other site
246195003024	tetramer interface [polypeptide binding]; other site
246195003025	hypothetical protein; Validated; Region: PRK00153
246195003026	DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994
246195003027	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
246195003028	Walker A motif; other site
246195003029	ATP binding site [chemical binding]; other site
246195003030	Walker B motif; other site
246195003031	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
246195003032	Ankyrin repeats (many copies); Region: Ank_5; pfam13857
246195003033	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
246195003034	nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052
246195003035	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
246195003036	dimer interface [polypeptide binding]; other site
246195003037	ADP-ribose binding site [chemical binding]; other site
246195003038	active site
246195003039	nudix motif; other site
246195003040	metal binding site [ion binding]; metal-binding site
246195003041	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
246195003042	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
246195003043	Peptidase family M23; Region: Peptidase_M23; pfam01551
246195003044	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
246195003045	Nuclease-related domain; Region: NERD; pfam08378
246195003046	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
246195003047	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
246195003048	Transglycosylase SLT domain; Region: SLT_2; pfam13406
246195003049	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
246195003050	N-acetyl-D-glucosamine binding site [chemical binding]; other site
246195003051	catalytic residue [active]
246195003052	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
246195003053	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
246195003054	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
246195003055	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
246195003056	rod shape-determining protein MreC; Provisional; Region: PRK13922
246195003057	rod shape-determining protein MreC; Region: MreC; pfam04085
246195003058	rod shape-determining protein MreB; Provisional; Region: PRK13927
246195003059	MreB and similar proteins; Region: MreB_like; cd10225
246195003060	nucleotide binding site [chemical binding]; other site
246195003061	Mg binding site [ion binding]; other site
246195003062	putative protofilament interaction site [polypeptide binding]; other site
246195003063	RodZ interaction site [polypeptide binding]; other site
246195003064	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
246195003065	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
246195003066	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
246195003067	putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636
246195003068	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
246195003069	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
246195003070	ABC transporter; Region: ABC_tran_2; pfam12848
246195003071	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
246195003072	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
246195003073	S-adenosylmethionine synthetase; Validated; Region: PRK05250
246195003074	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
246195003075	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
246195003076	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
246195003077	active site
246195003078	8-oxo-dGMP binding site [chemical binding]; other site
246195003079	nudix motif; other site
246195003080	metal binding site [ion binding]; metal-binding site
246195003081	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
246195003082	DEAD/DEAH box helicase; Region: DEAD; pfam00270
246195003083	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
246195003084	SEC-C motif; Region: SEC-C; pfam02810
246195003085	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186
246195003086	UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331
246195003087	cell division protein FtsZ; Validated; Region: PRK09330
246195003088	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
246195003089	nucleotide binding site [chemical binding]; other site
246195003090	SulA interaction site; other site
246195003091	cell division protein FtsA; Region: ftsA; TIGR01174
246195003092	Cell division protein FtsA; Region: FtsA; smart00842
246195003093	Cell division protein FtsA; Region: FtsA; pfam14450
246195003094	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
246195003095	Cell division protein FtsQ; Region: FtsQ; pfam03799
246195003096	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
246195003097	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
246195003098	ATP-grasp domain; Region: ATP-grasp_4; cl17255
246195003099	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
246195003100	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
246195003101	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
246195003102	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
246195003103	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
246195003104	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
246195003105	active site
246195003106	homodimer interface [polypeptide binding]; other site
246195003107	cell division protein FtsW; Region: ftsW; TIGR02614
246195003108	UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell envelope biogenesis, outer membrane]; Region: MurD; COG0771
246195003109	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
246195003110	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
246195003111	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
246195003112	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
246195003113	Mg++ binding site [ion binding]; other site
246195003114	putative catalytic motif [active]
246195003115	putative substrate binding site [chemical binding]; other site
246195003116	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
246195003117	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
246195003118	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
246195003119	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
246195003120	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
246195003121	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
246195003122	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
246195003123	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
246195003124	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
246195003125	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
246195003126	Cell division protein FtsL; Region: FtsL; cl11433
246195003127	MraW methylase family; Region: Methyltransf_5; cl17771
246195003128	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
246195003129	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2914
246195003130	Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813
246195003131	putative coenzyme Q binding site [chemical binding]; other site
246195003132	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
246195003133	SmpB-tmRNA interface; other site
246195003134	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
246195003135	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
246195003136	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
246195003137	substrate binding pocket [chemical binding]; other site
246195003138	membrane-bound complex binding site; other site
246195003139	hinge residues; other site
246195003140	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
246195003141	putative acyl-acceptor binding pocket; other site
246195003142	Maf-like protein; Region: Maf; pfam02545
246195003143	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
246195003144	active site
246195003145	dimer interface [polypeptide binding]; other site
246195003146	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
246195003147	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
246195003148	tandem repeat interface [polypeptide binding]; other site
246195003149	oligomer interface [polypeptide binding]; other site
246195003150	active site residues [active]
246195003151	23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025
246195003152	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
246195003153	RNA binding surface [nucleotide binding]; other site
246195003154	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
246195003155	active site
246195003156	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974
246195003157	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
246195003158	acyl-activating enzyme (AAE) consensus motif; other site
246195003159	putative AMP binding site [chemical binding]; other site
246195003160	putative active site [active]
246195003161	putative CoA binding site [chemical binding]; other site
246195003162	phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261
246195003163	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
246195003164	Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602
246195003165	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
246195003166	S-adenosylmethionine binding site [chemical binding]; other site
246195003167	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
246195003168	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
246195003169	active site
246195003170	(T/H)XGH motif; other site
246195003171	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
246195003172	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
246195003173	RimM N-terminal domain; Region: RimM; pfam01782
246195003174	PRC-barrel domain; Region: PRC; pfam05239
246195003175	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
246195003176	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
246195003177	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
246195003178	active site
246195003179	hypothetical protein; Provisional; Region: PRK09126
246195003180	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
246195003181	Invasion associated locus B (IalB) protein; Region: IalB; pfam06776
246195003182	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
246195003183	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
246195003184	motif II; other site
246195003185	Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864
246195003186	ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192
246195003187	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
246195003188	ATP binding site [chemical binding]; other site
246195003189	Mg++ binding site [ion binding]; other site
246195003190	motif III; other site
246195003191	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
246195003192	nucleotide binding region [chemical binding]; other site
246195003193	ATP-binding site [chemical binding]; other site
246195003194	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
246195003195	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
246195003196	ssDNA binding site; other site
246195003197	generic binding surface II; other site
246195003198	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
246195003199	ATP binding site [chemical binding]; other site
246195003200	putative Mg++ binding site [ion binding]; other site
246195003201	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
246195003202	nucleotide binding region [chemical binding]; other site
246195003203	ATP-binding site [chemical binding]; other site
246195003204	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
246195003205	homotrimer interaction site [polypeptide binding]; other site
246195003206	putative active site [active]
246195003207	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
246195003208	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
246195003209	Zn2+ binding site [ion binding]; other site
246195003210	Mg2+ binding site [ion binding]; other site
246195003211	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
246195003212	synthetase active site [active]
246195003213	NTP binding site [chemical binding]; other site
246195003214	metal binding site [ion binding]; metal-binding site
246195003215	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
246195003216	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
246195003217	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
246195003218	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cl00246
246195003219	FAD binding site [chemical binding]; other site
246195003220	pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558
246195003221	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
246195003222	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
246195003223	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
246195003224	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
246195003225	inhibitor-cofactor binding pocket; inhibition site
246195003226	pyridoxal 5'-phosphate binding site [chemical binding]; other site
246195003227	catalytic residue [active]
246195003228	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
246195003229	fumarate reductase flavoprotein subunit; Validated; Region: PRK09231
246195003230	L-aspartate oxidase; Provisional; Region: PRK06175
246195003231	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
246195003232	Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit [Energy production and conversion]; Region: FrdB; COG0479
246195003233	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
246195003234	Succinate:quinone oxidoreductase (SQR) and Quinol:fumarate reductase (QFR) family, transmembrane subunits; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol, while QFR catalyzes the reverse reaction. SQR; Region: SQR_QFR_TM; cl00881
246195003235	Iron-sulfur protein interface; other site
246195003236	proximal heme binding site [chemical binding]; other site
246195003237	Succinate:quinone oxidoreductase (SQR) and Quinol:fumarate reductase (QFR) family, transmembrane subunits; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol, while QFR catalyzes the reverse reaction. SQR; Region: SQR_QFR_TM; cl00881
246195003238	Iron-sulfur protein interface; other site
246195003239	proximal heme binding site [chemical binding]; other site
246195003240	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
246195003241	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
246195003242	putative active site [active]
246195003243	NAD-dependent deacetylase; Provisional; Region: PRK00481
246195003244	SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412
246195003245	NAD+ binding site [chemical binding]; other site
246195003246	substrate binding site [chemical binding]; other site
246195003247	Zn binding site [ion binding]; other site
246195003248	carboxy-terminal protease; Provisional; Region: PRK11186
246195003249	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
246195003250	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
246195003251	protein binding site [polypeptide binding]; other site
246195003252	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
246195003253	Catalytic dyad [active]
246195003254	C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818
246195003255	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
246195003256	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
246195003257	TPP-binding site [chemical binding]; other site
246195003258	dimer interface [polypeptide binding]; other site
246195003259	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
246195003260	PYR/PP interface [polypeptide binding]; other site
246195003261	dimer interface [polypeptide binding]; other site
246195003262	TPP binding site [chemical binding]; other site
246195003263	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
246195003264	phosphoglycerate kinase; Provisional; Region: pgk; PRK00073
246195003265	Phosphoglycerate kinase; Region: PGK; pfam00162
246195003266	substrate binding site [chemical binding]; other site
246195003267	hinge regions; other site
246195003268	ADP binding site [chemical binding]; other site
246195003269	catalytic site [active]
246195003270	Protein of unknown function (DUF1624); Region: DUF1624; cl01394
246195003271	Acyltransferase family; Region: Acyl_transf_3; pfam01757
246195003272	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
246195003273	Plasmid maintenance system killer protein; Region: Plasmid_killer; pfam05015
246195003274	Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093
246195003275	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
246195003276	sequence-specific DNA binding site [nucleotide binding]; other site
246195003277	salt bridge; other site
246195003278	Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456
246195003279	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
246195003280	oligomeric interface; other site
246195003281	putative active site [active]
246195003282	homodimer interface [polypeptide binding]; other site
246195003283	Predicted P-loop ATPase and inactivated derivatives [General function prediction only]; Region: COG5545
246195003284	Virulence-associated protein E; Region: VirE; pfam05272
246195003285	integrase; Provisional; Region: PRK09692
246195003286	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
246195003287	active site
246195003288	Int/Topo IB signature motif; other site
246195003289	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
246195003290	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
246195003291	RNase E interface [polypeptide binding]; other site
246195003292	trimer interface [polypeptide binding]; other site
246195003293	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
246195003294	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
246195003295	RNase E interface [polypeptide binding]; other site
246195003296	trimer interface [polypeptide binding]; other site
246195003297	active site
246195003298	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
246195003299	putative nucleic acid binding region [nucleotide binding]; other site
246195003300	G-X-X-G motif; other site
246195003301	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
246195003302	RNA binding site [nucleotide binding]; other site
246195003303	domain interface; other site
246195003304	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
246195003305	16S/18S rRNA binding site [nucleotide binding]; other site
246195003306	S13e-L30e interaction site [polypeptide binding]; other site
246195003307	25S rRNA binding site [nucleotide binding]; other site
246195003308	Cupredoxin-like domain; Region: Cupredoxin_1; cl17234
246195003309	Sporulation related domain; Region: SPOR; pfam05036
246195003310	Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018
246195003311	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
246195003312	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
246195003313	active site
246195003314	HIGH motif; other site
246195003315	nucleotide binding site [chemical binding]; other site
246195003316	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
246195003317	KMSK motif region; other site
246195003318	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
246195003319	tRNA binding surface [nucleotide binding]; other site
246195003320	anticodon binding site; other site
246195003321	tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815
246195003322	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
246195003323	FMN binding site [chemical binding]; other site
246195003324	active site
246195003325	catalytic residues [active]
246195003326	substrate binding site [chemical binding]; other site
246195003327	aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598
246195003328	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
246195003329	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
246195003330	ATP binding site [chemical binding]; other site
246195003331	putative Mg++ binding site [ion binding]; other site
246195003332	Family description; Region: UvrD_C_2; pfam13538
246195003333	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
246195003334	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
246195003335	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
246195003336	dimer interface [polypeptide binding]; other site
246195003337	motif 1; other site
246195003338	active site
246195003339	motif 2; other site
246195003340	motif 3; other site
246195003341	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
246195003342	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
246195003343	putative tRNA-binding site [nucleotide binding]; other site
246195003344	B3/4 domain; Region: B3_4; pfam03483
246195003345	tRNA synthetase B5 domain; Region: B5; smart00874
246195003346	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
246195003347	dimer interface [polypeptide binding]; other site
246195003348	motif 1; other site
246195003349	motif 3; other site
246195003350	motif 2; other site
246195003351	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
246195003352	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
246195003353	IHF dimer interface [polypeptide binding]; other site
246195003354	IHF - DNA interface [nucleotide binding]; other site
246195003355	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
246195003356	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
246195003357	putative acyl-acceptor binding pocket; other site
246195003358	D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942
246195003359	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
246195003360	active site
246195003361	motif I; other site
246195003362	motif II; other site
246195003363	Predicted P-loop ATPase fused to an acetyltransferase [General function prediction only]; Region: COG1444
246195003364	Helicase; Region: Helicase_RecD; pfam05127
246195003365	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
246195003366	Coenzyme A binding pocket [chemical binding]; other site
246195003367	multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885
246195003368	RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966
246195003369	metal binding triad [ion binding]; metal-binding site
246195003370	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
246195003371	NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255
246195003372	ATP-NAD kinase; Region: NAD_kinase; pfam01513
246195003373	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
246195003374	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
246195003375	Walker A/P-loop; other site
246195003376	ATP binding site [chemical binding]; other site
246195003377	Q-loop/lid; other site
246195003378	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
246195003379	Q-loop/lid; other site
246195003380	ABC transporter signature motif; other site
246195003381	Walker B; other site
246195003382	D-loop; other site
246195003383	H-loop/switch region; other site
246195003384	SmpA / OmlA family; Region: SmpA_OmlA; pfam04355
246195003385	seryl-tRNA synthetase; Provisional; Region: PRK05431
246195003386	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
246195003387	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
246195003388	dimer interface [polypeptide binding]; other site
246195003389	active site
246195003390	motif 1; other site
246195003391	motif 2; other site
246195003392	motif 3; other site
246195003393	transcriptional regulator PhoU; Provisional; Region: PRK11115
246195003394	PhoU domain; Region: PhoU; pfam01895
246195003395	PhoU domain; Region: PhoU; pfam01895
246195003396	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
246195003397	NlpC/P60 family; Region: NLPC_P60; pfam00877
246195003398	Dicarboxylate transport; Region: DctA-YdbH; cl14674
246195003399	glycine dehydrogenase; Provisional; Region: PRK05367
246195003400	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
246195003401	tetramer interface [polypeptide binding]; other site
246195003402	pyridoxal 5'-phosphate binding site [chemical binding]; other site
246195003403	catalytic residue [active]
246195003404	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
246195003405	tetramer interface [polypeptide binding]; other site
246195003406	pyridoxal 5'-phosphate binding site [chemical binding]; other site
246195003407	catalytic residue [active]
246195003408	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
246195003409	lipoyl attachment site [posttranslational modification]; other site
246195003410	adenylate kinase; Reviewed; Region: adk; PRK00279
246195003411	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
246195003412	AMP-binding site [chemical binding]; other site
246195003413	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
246195003414	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
246195003415	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
246195003416	Tetramer interface [polypeptide binding]; other site
246195003417	active site
246195003418	FMN-binding site [chemical binding]; other site
246195003419	carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454
246195003420	AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235
246195003421	putative substrate binding site [chemical binding]; other site
246195003422	nucleotide binding site [chemical binding]; other site
246195003423	nucleotide binding site [chemical binding]; other site
246195003424	homodimer interface [polypeptide binding]; other site
246195003425	ornithine carbamoyltransferase; Provisional; Region: PRK01713
246195003426	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
246195003427	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
246195003428	arginine deiminase; Provisional; Region: PRK01388
246195003429	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
246195003430	homooctamer interface [polypeptide binding]; other site
246195003431	active site
246195003432	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
246195003433	RNA polymerase sigma factor RpoD; Validated; Region: PRK05658
246195003434	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
246195003435	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
246195003436	Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546
246195003437	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
246195003438	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
246195003439	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
246195003440	DNA binding residues [nucleotide binding]
246195003441	DNA primase; Validated; Region: dnaG; PRK05667
246195003442	CHC2 zinc finger; Region: zf-CHC2; pfam01807
246195003443	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
246195003444	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
246195003445	active site
246195003446	metal binding site [ion binding]; metal-binding site
246195003447	interdomain interaction site; other site
246195003448	Yqey-like protein; Region: YqeY; cl17540
246195003449	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
246195003450	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
246195003451	23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168
246195003452	TRAM domain; Region: TRAM; pfam01938
246195003453	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
246195003454	S-adenosylmethionine binding site [chemical binding]; other site
246195003455	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
246195003456	active site
246195003457	dimer interface [polypeptide binding]; other site
246195003458	metal binding site [ion binding]; metal-binding site
246195003459	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883
246195003460	active site clefts [active]
246195003461	zinc binding site [ion binding]; other site
246195003462	dimer interface [polypeptide binding]; other site
246195003463	Transglycosylase SLT domain; Region: SLT_2; pfam13406
246195003464	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
246195003465	N-acetyl-D-glucosamine binding site [chemical binding]; other site
246195003466	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
246195003467	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
246195003468	tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696
246195003469	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_II; cd01993
246195003470	Ligand Binding Site [chemical binding]; other site
246195003471	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
246195003472	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
246195003473	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
246195003474	putative binding surface; other site
246195003475	active site
246195003476	Hpt domain; Region: Hpt; pfam01627
246195003477	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
246195003478	putative binding surface; other site
246195003479	active site
246195003480	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
246195003481	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
246195003482	ATP binding site [chemical binding]; other site
246195003483	Mg2+ binding site [ion binding]; other site
246195003484	G-X-G motif; other site
246195003485	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
246195003486	Response regulator receiver domain; Region: Response_reg; pfam00072
246195003487	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
246195003488	active site
246195003489	phosphorylation site [posttranslational modification]
246195003490	intermolecular recognition site; other site
246195003491	dimerization interface [polypeptide binding]; other site
246195003492	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
246195003493	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
246195003494	dimer interface [polypeptide binding]; other site
246195003495	putative CheW interface [polypeptide binding]; other site
246195003496	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588
246195003497	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
246195003498	active site
246195003499	phosphorylation site [posttranslational modification]
246195003500	intermolecular recognition site; other site
246195003501	dimerization interface [polypeptide binding]; other site
246195003502	Response regulator receiver domain; Region: Response_reg; pfam00072
246195003503	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
246195003504	active site
246195003505	phosphorylation site [posttranslational modification]
246195003506	intermolecular recognition site; other site
246195003507	dimerization interface [polypeptide binding]; other site
246195003508	Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652
246195003509	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
246195003510	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
246195003511	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
246195003512	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
246195003513	E3 interaction surface; other site
246195003514	lipoyl attachment site [posttranslational modification]; other site
246195003515	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467
246195003516	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
246195003517	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
246195003518	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
246195003519	Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656
246195003520	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
246195003521	RNA/DNA hybrid binding site [nucleotide binding]; other site
246195003522	active site
246195003523	Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547
246195003524	Protein of unknown function (DUF465); Region: DUF465; cl01070
246195003525	polyphosphate kinase; Provisional; Region: PRK05443
246195003526	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
246195003527	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
246195003528	Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165
246195003529	putative domain interface [polypeptide binding]; other site
246195003530	putative active site [active]
246195003531	catalytic site [active]
246195003532	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
246195003533	putative domain interface [polypeptide binding]; other site
246195003534	putative active site [active]
246195003535	catalytic site [active]
246195003536	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
246195003537	The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual proteins of this...; Region: Band_7; cl02525
246195003538	glutaminyl-tRNA synthetase; Provisional; Region: PRK05347
246195003539	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
246195003540	active site
246195003541	HIGH motif; other site
246195003542	nucleotide binding site [chemical binding]; other site
246195003543	catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807
246195003544	KMSKS motif; other site
246195003545	tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950
246195003546	OsmC-like protein; Region: OsmC; pfam02566
246195003547	phosphoribosylformylglycinamidine synthase, clade II; Region: FGAM-synthase; TIGR01857
246195003548	AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019
246195003549	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
246195003550	dimerization interface [polypeptide binding]; other site
246195003551	ATP binding site [chemical binding]; other site
246195003552	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
246195003553	dimerization interface [polypeptide binding]; other site
246195003554	ATP binding site [chemical binding]; other site
246195003555	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
246195003556	conserved cys residue [active]
246195003557	Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530
246195003558	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
246195003559	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
246195003560	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
246195003561	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
246195003562	ATP binding site [chemical binding]; other site
246195003563	active site
246195003564	substrate binding site [chemical binding]; other site
246195003565	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
246195003566	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
246195003567	dimerization interface [polypeptide binding]; other site
246195003568	putative ATP binding site [chemical binding]; other site
246195003569	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
246195003570	dihydrodipicolinate synthase; Region: dapA; TIGR00674
246195003571	dimer interface [polypeptide binding]; other site
246195003572	active site
246195003573	catalytic residue [active]
246195003574	Uncharacterized lipoprotein [Cell envelope biogenesis, outer membrane]; Region: NlpB; COG3317
246195003575	NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804
246195003576	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
246195003577	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
246195003578	ATP binding site [chemical binding]; other site
246195003579	Mg2+ binding site [ion binding]; other site
246195003580	G-X-G motif; other site
246195003581	MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL.  EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family.  This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482
246195003582	ATP binding site [chemical binding]; other site
246195003583	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
246195003584	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
246195003585	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
246195003586	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
246195003587	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
246195003588	dimer interface [polypeptide binding]; other site
246195003589	anticodon binding site; other site
246195003590	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
246195003591	homodimer interface [polypeptide binding]; other site
246195003592	motif 1; other site
246195003593	active site
246195003594	motif 2; other site
246195003595	GAD domain; Region: GAD; pfam02938
246195003596	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
246195003597	motif 3; other site
246195003598	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
246195003599	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
246195003600	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
246195003601	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
246195003602	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
246195003603	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
246195003604	Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349
246195003605	catalytic site [active]
246195003606	putative active site [active]
246195003607	putative substrate binding site [chemical binding]; other site
246195003608	Helicase and RNase D C-terminal; Region: HRDC; smart00341
246195003609	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
246195003610	dephospho-CoA kinase; Region: TIGR00152
246195003611	CoA-binding site [chemical binding]; other site
246195003612	ATP-binding [chemical binding]; other site
246195003613	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
246195003614	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
246195003615	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
246195003616	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
246195003617	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
246195003618	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
246195003619	type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538
246195003620	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
246195003621	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
246195003622	Walker A motif; other site
246195003623	ATP binding site [chemical binding]; other site
246195003624	Walker B motif; other site
246195003625	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
246195003626	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
246195003627	glutamine binding [chemical binding]; other site
246195003628	catalytic triad [active]
246195003629	Recombinational DNA repair protein (RecF pathway) [DNA replication, recombination, and repair]; Region: RecO; COG1381
246195003630	Recombination protein O N terminal; Region: RecO_N; pfam11967
246195003631	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
246195003632	23S rRNA interface [nucleotide binding]; other site
246195003633	L3 interface [polypeptide binding]; other site
246195003634	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
246195003635	site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283
246195003636	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
246195003637	active site
246195003638	DNA binding site [nucleotide binding]
246195003639	Int/Topo IB signature motif; other site
246195003640	ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822
246195003641	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
246195003642	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
246195003643	DNA binding site [nucleotide binding]
246195003644	catalytic residue [active]
246195003645	H2TH interface [polypeptide binding]; other site
246195003646	putative catalytic residues [active]
246195003647	turnover-facilitating residue; other site
246195003648	intercalation triad [nucleotide binding]; other site
246195003649	8OG recognition residue [nucleotide binding]; other site
246195003650	putative reading head residues; other site
246195003651	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
246195003652	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
246195003653	Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575
246195003654	tRNA pseudouridine synthase D (TruD); Region: TruD; pfam01142
246195003655	Permutation of conserved domain; other site
246195003656	active site
246195003657	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
246195003658	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
246195003659	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762
246195003660	substrate binding site [chemical binding]; other site
246195003661	oxyanion hole (OAH) forming residues; other site
246195003662	trimer interface [polypeptide binding]; other site
246195003663	prolyl-tRNA synthetase; Provisional; Region: PRK09194
246195003664	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
246195003665	dimer interface [polypeptide binding]; other site
246195003666	motif 1; other site
246195003667	active site
246195003668	motif 2; other site
246195003669	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
246195003670	putative deacylase active site [active]
246195003671	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
246195003672	active site
246195003673	motif 3; other site
246195003674	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
246195003675	anticodon binding site; other site
246195003676	Domain of unknown function (DUF4124); Region: DUF4124; pfam13511
246195003677	N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) [Cell envelope biogenesis, outer membrane]; Region: GlmU; COG1207
246195003678	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
246195003679	Substrate binding site; other site
246195003680	Mg++ binding site; other site
246195003681	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
246195003682	active site
246195003683	substrate binding site [chemical binding]; other site
246195003684	CoA binding site [chemical binding]; other site
246195003685	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
246195003686	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
246195003687	gamma subunit interface [polypeptide binding]; other site
246195003688	LBP interface [polypeptide binding]; other site
246195003689	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
246195003690	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
246195003691	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
246195003692	alpha subunit interaction interface [polypeptide binding]; other site
246195003693	Walker A motif; other site
246195003694	ATP binding site [chemical binding]; other site
246195003695	Walker B motif; other site
246195003696	inhibitor binding site; inhibition site
246195003697	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
246195003698	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
246195003699	core domain interface [polypeptide binding]; other site
246195003700	delta subunit interface [polypeptide binding]; other site
246195003701	epsilon subunit interface [polypeptide binding]; other site
246195003702	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
246195003703	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
246195003704	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
246195003705	beta subunit interaction interface [polypeptide binding]; other site
246195003706	Walker A motif; other site
246195003707	ATP binding site [chemical binding]; other site
246195003708	Walker B motif; other site
246195003709	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
246195003710	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
246195003711	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
246195003712	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
246195003713	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
246195003714	F0F1 ATP synthase subunit C; Validated; Region: PRK06876
246195003715	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
246195003716	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
246195003717	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
246195003718	ParB-like nuclease domain; Region: ParBc; pfam02195
246195003719	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
246195003720	16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107
246195003721	multifunctional aminopeptidase A; Provisional; Region: PRK00913
246195003722	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
246195003723	interface (dimer of trimers) [polypeptide binding]; other site
246195003724	Substrate-binding/catalytic site; other site
246195003725	Zn-binding sites [ion binding]; other site
246195003726	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
246195003727	Predicted permeases [General function prediction only]; Region: COG0795
246195003728	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
246195003729	Predicted permeases [General function prediction only]; Region: COG0795
246195003730	Membrane fusogenic activity; Region: BMFP; cl01115
246195003731	Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097
246195003732	potassium/proton antiporter; Reviewed; Region: PRK05326
246195003733	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
246195003734	Transporter associated domain; Region: CorC_HlyC; smart01091
246195003735	Protein of unknown function, DUF486; Region: DUF486; cl01236
246195003736	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
246195003737	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
246195003738	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
246195003739	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
246195003740	RNA binding site [nucleotide binding]; other site
246195003741	D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344
246195003742	Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Saccharomyces cerevisiae biotin-apoprotein ligase (ScBLP); Region: GATase1_ScBLP_like; cd03144
246195003743	conserved cys residue [active]
246195003744	BioY family; Region: BioY; pfam02632
246195003745	tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031
246195003746	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
246195003747	S-adenosylmethionine binding site [chemical binding]; other site
246195003748	exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609
246195003749	Family description; Region: UvrD_C_2; pfam13538
246195003750	Peptidase S8 family domain, uncharacterized subfamily 13; Region: Peptidases_S8_13; cd07496
246195003751	active site
246195003752	catalytic triad [active]
246195003753	Proprotein convertase P-domain; Region: P_proprotein; pfam01483
246195003754	Murein lipoprotein [Cell envelope biogenesis, outer membrane]; Region: COG4238; cl11539
246195003755	Tetratricopeptide repeat; Region: TPR_16; pfam13432
246195003756	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
246195003757	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
246195003758	ligand binding site [chemical binding]; other site
246195003759	translocation protein TolB; Provisional; Region: tolB; PRK04922
246195003760	TolB amino-terminal domain; Region: TolB_N; pfam04052
246195003761	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
246195003762	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
246195003763	Gram-negative bacterial tonB protein; Region: TonB; cl10048
246195003764	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
246195003765	TolR protein; Region: tolR; TIGR02801
246195003766	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
246195003767	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
246195003768	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
246195003769	Walker A motif; other site
246195003770	ATP binding site [chemical binding]; other site
246195003771	Walker B motif; other site
246195003772	arginine finger; other site
246195003773	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
246195003774	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
246195003775	RuvA N terminal domain; Region: RuvA_N; pfam01330
246195003776	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
246195003777	active site
246195003778	putative DNA-binding cleft [nucleotide binding]; other site
246195003779	dimer interface [polypeptide binding]; other site
246195003780	hypothetical protein; Validated; Region: PRK00110
246195003781	ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226
246195003782	Phosphate ATP-binding cassette transporter; Region: DUF3708; pfam12501
246195003783	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
246195003784	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
246195003785	dimer interface [polypeptide binding]; other site
246195003786	conserved gate region; other site
246195003787	putative PBP binding loops; other site
246195003788	ABC-ATPase subunit interface; other site
246195003789	Domain of unknown function (DUF3333); Region: DUF3333; pfam11812
246195003790	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
246195003791	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
246195003792	dimer interface [polypeptide binding]; other site
246195003793	conserved gate region; other site
246195003794	putative PBP binding loops; other site
246195003795	ABC-ATPase subunit interface; other site
246195003796	phosphate transporter ATP-binding protein; Provisional; Region: PRK14235
246195003797	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
246195003798	Walker A/P-loop; other site
246195003799	ATP binding site [chemical binding]; other site
246195003800	Q-loop/lid; other site
246195003801	ABC transporter signature motif; other site
246195003802	Walker B; other site
246195003803	D-loop; other site
246195003804	H-loop/switch region; other site
246195003805	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
246195003806	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
246195003807	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
246195003808	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
246195003809	Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
246195003810	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
246195003811	transmembrane helices; other site
246195003812	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
246195003813	TrkA-C domain; Region: TrkA_C; pfam02080
246195003814	TrkA-C domain; Region: TrkA_C; pfam02080
246195003815	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
246195003816	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
246195003817	periplasmic multidrug efflux lipoprotein precursor; Reviewed; Region: PRK09578
246195003818	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
246195003819	HlyD family secretion protein; Region: HlyD_3; pfam13437
246195003820	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
246195003821	Protein export membrane protein; Region: SecD_SecF; cl14618
246195003822	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
246195003823	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
246195003824	cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235
246195003825	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
246195003826	catalytic residue [active]
246195003827	glycine cleavage system aminomethyltransferase T; Provisional; Region: gcvT; PRK13579
246195003828	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
246195003829	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
246195003830	rRNA binding site [nucleotide binding]; other site
246195003831	predicted 30S ribosome binding site; other site
246195003832	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
246195003833	Ankyrin repeat; Region: Ank; pfam00023
246195003834	pyruvate kinase; Provisional; Region: PRK05826
246195003835	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
246195003836	domain interfaces; other site
246195003837	active site
246195003838	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
246195003839	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
246195003840	N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023
246195003841	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
246195003842	amidase catalytic site [active]
246195003843	Zn binding residues [ion binding]; other site
246195003844	substrate binding site [chemical binding]; other site
246195003845	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
246195003846	Uncharacterized ACR, COG1399; Region: DUF177; pfam02620
246195003847	50S ribosomal protein L32; Validated; Region: rpmF; PRK01110
246195003848	putative phosphate acyltransferase; Provisional; Region: PRK05331
246195003849	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
246195003850	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
246195003851	dimer interface [polypeptide binding]; other site
246195003852	active site
246195003853	CoA binding pocket [chemical binding]; other site
246195003854	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
246195003855	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
246195003856	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
246195003857	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
246195003858	NAD(P) binding site [chemical binding]; other site
246195003859	homotetramer interface [polypeptide binding]; other site
246195003860	homodimer interface [polypeptide binding]; other site
246195003861	active site
246195003862	acyl carrier protein; Provisional; Region: acpP; PRK00982
246195003863	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
246195003864	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
246195003865	dimer interface [polypeptide binding]; other site
246195003866	active site
246195003867	YceG-like family; Region: YceG; pfam02618
246195003868	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
246195003869	dimerization interface [polypeptide binding]; other site
246195003870	thymidylate kinase; Validated; Region: tmk; PRK00698
246195003871	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
246195003872	TMP-binding site; other site
246195003873	ATP-binding site [chemical binding]; other site
246195003874	DNA polymerase III, delta' subunit; Region: holB; TIGR00678
246195003875	DNA polymerase III subunit delta'; Validated; Region: PRK08485
246195003876	ATPase involved in DNA replication [DNA replication, recombination, and repair]; Region: HolB; COG0470
246195003877	PilZ domain; Region: PilZ; cl01260
246195003878	Integral membrane protein TerC family; Region: TerC; cl10468
246195003879	Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352
246195003880	glutathione synthetase; Provisional; Region: PRK05246
246195003881	Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951
246195003882	Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955
246195003883	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
246195003884	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
246195003885	putative active site [active]
246195003886	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
246195003887	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
246195003888	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
246195003889	Repair protein; Region: Repair_PSII; pfam04536
246195003890	Repair protein; Region: Repair_PSII; pfam04536
246195003891	Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704
246195003892	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
246195003893	active site residue [active]
246195003894	lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212
246195003895	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
246195003896	FtsX-like permease family; Region: FtsX; pfam02687
246195003897	lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211
246195003898	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
246195003899	Walker A/P-loop; other site
246195003900	ATP binding site [chemical binding]; other site
246195003901	Q-loop/lid; other site
246195003902	ABC transporter signature motif; other site
246195003903	Walker B; other site
246195003904	D-loop; other site
246195003905	H-loop/switch region; other site
246195003906	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
246195003907	Helix-hairpin-helix motif; Region: HHH; pfam00633
246195003908	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
246195003909	6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
246195003910	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
246195003911	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
246195003912	dihydropteroate synthase; Region: DHPS; TIGR01496
246195003913	substrate binding pocket [chemical binding]; other site
246195003914	dimer interface [polypeptide binding]; other site
246195003915	inhibitor binding site; inhibition site
246195003916	FtsH Extracellular; Region: FtsH_ext; pfam06480
246195003917	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
246195003918	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
246195003919	Walker A motif; other site
246195003920	ATP binding site [chemical binding]; other site
246195003921	Walker B motif; other site
246195003922	arginine finger; other site
246195003923	Peptidase family M41; Region: Peptidase_M41; pfam01434
246195003924	23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293
246195003925	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
246195003926	S-adenosylmethionine binding site [chemical binding]; other site
246195003927	Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534
246195003928	Transferrin binding protein-like solute binding protein; Region: Lipoprotein_5; pfam01298
246195003929	metal-binding heat shock protein; Provisional; Region: PRK00016
246195003930	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
246195003931	PhoH-like protein; Region: PhoH; pfam02562
246195003932	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325
246195003933	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
246195003934	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
246195003935	FeS/SAM binding site; other site
246195003936	TRAM domain; Region: TRAM; pfam01938
246195003937	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
246195003938	Sel1-like repeats; Region: SEL1; smart00671
246195003939	tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121
246195003940	putative GTP cyclohydrolase; Provisional; Region: PRK13674
246195003941	ferrochelatase; Reviewed; Region: hemH; PRK00035
246195003942	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
246195003943	C-terminal domain interface [polypeptide binding]; other site
246195003944	active site
246195003945	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
246195003946	active site
246195003947	N-terminal domain interface [polypeptide binding]; other site
246195003948	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
246195003949	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
246195003950	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
246195003951	alphaNTD homodimer interface [polypeptide binding]; other site
246195003952	alphaNTD - beta interaction site [polypeptide binding]; other site
246195003953	alphaNTD - beta' interaction site [polypeptide binding]; other site
246195003954	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
246195003955	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
246195003956	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
246195003957	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
246195003958	RNA binding surface [nucleotide binding]; other site
246195003959	30S ribosomal protein S11; Validated; Region: PRK05309
246195003960	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
246195003961	30S ribosomal protein S13; Region: bact_S13; TIGR03631
246195003962	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
246195003963	SecY translocase; Region: SecY; pfam00344
246195003964	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
246195003965	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
246195003966	23S rRNA binding site [nucleotide binding]; other site
246195003967	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
246195003968	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
246195003969	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
246195003970	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
246195003971	23S rRNA interface [nucleotide binding]; other site
246195003972	L21e interface [polypeptide binding]; other site
246195003973	5S rRNA interface [nucleotide binding]; other site
246195003974	L27 interface [polypeptide binding]; other site
246195003975	L5 interface [polypeptide binding]; other site
246195003976	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
246195003977	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
246195003978	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
246195003979	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
246195003980	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
246195003981	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
246195003982	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
246195003983	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
246195003984	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
246195003985	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
246195003986	RNA binding site [nucleotide binding]; other site
246195003987	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
246195003988	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
246195003989	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
246195003990	putative translocon interaction site; other site
246195003991	23S rRNA interface [nucleotide binding]; other site
246195003992	signal recognition particle (SRP54) interaction site; other site
246195003993	L23 interface [polypeptide binding]; other site
246195003994	trigger factor interaction site; other site
246195003995	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
246195003996	23S rRNA interface [nucleotide binding]; other site
246195003997	5S rRNA interface [nucleotide binding]; other site
246195003998	putative antibiotic binding site [chemical binding]; other site
246195003999	L25 interface [polypeptide binding]; other site
246195004000	L27 interface [polypeptide binding]; other site
246195004001	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
246195004002	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
246195004003	G-X-X-G motif; other site
246195004004	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
246195004005	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
246195004006	protein-rRNA interface [nucleotide binding]; other site
246195004007	putative translocon binding site; other site
246195004008	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
246195004009	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
246195004010	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
246195004011	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
246195004012	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
246195004013	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
246195004014	50S ribosomal protein L3, bacterial; Region: L3_bact; TIGR03625
246195004015	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
246195004016	elongation factor Tu; Reviewed; Region: PRK00049
246195004017	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
246195004018	G1 box; other site
246195004019	GEF interaction site [polypeptide binding]; other site
246195004020	GTP/Mg2+ binding site [chemical binding]; other site
246195004021	Switch I region; other site
246195004022	G2 box; other site
246195004023	G3 box; other site
246195004024	Switch II region; other site
246195004025	G4 box; other site
246195004026	G5 box; other site
246195004027	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
246195004028	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
246195004029	Antibiotic Binding Site [chemical binding]; other site
246195004030	elongation factor G; Reviewed; Region: PRK00007
246195004031	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
246195004032	G1 box; other site
246195004033	putative GEF interaction site [polypeptide binding]; other site
246195004034	GTP/Mg2+ binding site [chemical binding]; other site
246195004035	Switch I region; other site
246195004036	G2 box; other site
246195004037	G3 box; other site
246195004038	Switch II region; other site
246195004039	G4 box; other site
246195004040	G5 box; other site
246195004041	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
246195004042	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
246195004043	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
246195004044	30S ribosomal protein S7; Validated; Region: PRK05302
246195004045	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
246195004046	S17 interaction site [polypeptide binding]; other site
246195004047	S8 interaction site; other site
246195004048	16S rRNA interaction site [nucleotide binding]; other site
246195004049	streptomycin interaction site [chemical binding]; other site
246195004050	23S rRNA interaction site [nucleotide binding]; other site
246195004051	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
246195004052	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
246195004053	DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086
246195004054	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
246195004055	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
246195004056	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
246195004057	RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998
246195004058	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
246195004059	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
246195004060	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
246195004061	DNA binding site [nucleotide binding]
246195004062	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
246195004063	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
246195004064	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
246195004065	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
246195004066	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
246195004067	RPB11 interaction site [polypeptide binding]; other site
246195004068	RPB12 interaction site [polypeptide binding]; other site
246195004069	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
246195004070	RPB3 interaction site [polypeptide binding]; other site
246195004071	RPB1 interaction site [polypeptide binding]; other site
246195004072	RPB11 interaction site [polypeptide binding]; other site
246195004073	RPB10 interaction site [polypeptide binding]; other site
246195004074	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
246195004075	core dimer interface [polypeptide binding]; other site
246195004076	peripheral dimer interface [polypeptide binding]; other site
246195004077	L10 interface [polypeptide binding]; other site
246195004078	L11 interface [polypeptide binding]; other site
246195004079	putative EF-Tu interaction site [polypeptide binding]; other site
246195004080	putative EF-G interaction site [polypeptide binding]; other site
246195004081	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
246195004082	23S rRNA interface [nucleotide binding]; other site
246195004083	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
246195004084	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
246195004085	mRNA/rRNA interface [nucleotide binding]; other site
246195004086	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
246195004087	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
246195004088	23S rRNA interface [nucleotide binding]; other site
246195004089	L7/L12 interface [polypeptide binding]; other site
246195004090	putative thiostrepton binding site; other site
246195004091	L25 interface [polypeptide binding]; other site
246195004092	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
246195004093	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
246195004094	putative homodimer interface [polypeptide binding]; other site
246195004095	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
246195004096	heterodimer interface [polypeptide binding]; other site
246195004097	homodimer interface [polypeptide binding]; other site
246195004098	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740
246195004099	similar to elongation factor Tu; identified by match to protein family HMM PF00009; match to protein family HMM PF03143; match to protein family HMM PF03144; match to protein family HMM TIGR00231; match to protein family HMM TIGR00485
246195004100	diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166
246195004101	Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422
246195004102	active site
246195004103	metal binding site [ion binding]; metal-binding site
246195004104	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
246195004105	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
246195004106	active site
246195004107	catalytic tetrad [active]
246195004108	3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749
246195004109	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
246195004110	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
246195004111	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14188
246195004112	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
246195004113	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
246195004114	homodimer interface [polypeptide binding]; other site
246195004115	NADP binding site [chemical binding]; other site
246195004116	substrate binding site [chemical binding]; other site
246195004117	HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277
246195004118	HIT family signature motif; other site
246195004119	catalytic residue [active]
246195004120	H-NS histone family; Region: Histone_HNS; pfam00816
246195004121	Domain in histone-like proteins of HNS family; Region: HNS; smart00528
246195004122	Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028
246195004123	putative GSH binding site [chemical binding]; other site
246195004124	catalytic residues [active]
246195004125	Protein of unknown function (DUF560); Region: DUF560; pfam04575
246195004126	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
246195004127	MutS domain I; Region: MutS_I; pfam01624
246195004128	MutS domain II; Region: MutS_II; pfam05188
246195004129	MutS domain III; Region: MutS_III; pfam05192
246195004130	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
246195004131	Walker A/P-loop; other site
246195004132	ATP binding site [chemical binding]; other site
246195004133	Q-loop/lid; other site
246195004134	ABC transporter signature motif; other site
246195004135	Walker B; other site
246195004136	D-loop; other site
246195004137	H-loop/switch region; other site
246195004138	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
246195004139	Helix-hairpin-helix motif; Region: HHH; pfam00633
246195004140	outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302
246195004141	23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180
246195004142	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
246195004143	RNA binding surface [nucleotide binding]; other site
246195004144	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
246195004145	active site
246195004146	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
246195004147	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
246195004148	CoA-ligase; Region: Ligase_CoA; pfam00549
246195004149	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
246195004150	CoA binding domain; Region: CoA_binding; smart00881
246195004151	CoA-ligase; Region: Ligase_CoA; pfam00549
246195004152	muropeptide transporter; Validated; Region: ampG; cl17669
246195004153	muropeptide transporter; Validated; Region: ampG; cl17669
246195004154	23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783
246195004155	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
246195004156	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
246195004157	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
246195004158	S-adenosylmethionine binding site [chemical binding]; other site
246195004159	protein disulfide isomerase II DsbC; Provisional; Region: PRK10877
246195004160	DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020
246195004161	dimerization domain [polypeptide binding]; other site
246195004162	dimer interface [polypeptide binding]; other site
246195004163	catalytic residues [active]
246195004164	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
246195004165	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
246195004166	dimerization interface [polypeptide binding]; other site
246195004167	DPS ferroxidase diiron center [ion binding]; other site
246195004168	ion pore; other site
246195004169	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
246195004170	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
246195004171	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
246195004172	Protein of unknown function (DUF2753); Region: DUF2753; pfam10952
246195004173	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
246195004174	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
246195004175	active site
246195004176	HIGH motif; other site
246195004177	dimer interface [polypeptide binding]; other site
246195004178	KMSKS motif; other site
246195004179	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
246195004180	RNA binding surface [nucleotide binding]; other site
246195004181	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
246195004182	Peptidase family M23; Region: Peptidase_M23; pfam01551
246195004183	anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585
246195004184	CrcB-like protein; Region: CRCB; cl09114
246195004185	GTP-binding protein YchF; Reviewed; Region: PRK09601
246195004186	YchF GTPase; Region: YchF; cd01900
246195004187	G1 box; other site
246195004188	GTP/Mg2+ binding site [chemical binding]; other site
246195004189	Switch I region; other site
246195004190	G2 box; other site
246195004191	Switch II region; other site
246195004192	G3 box; other site
246195004193	G4 box; other site
246195004194	G5 box; other site
246195004195	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
246195004196	elongation factor P; Validated; Region: PRK00529
246195004197	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
246195004198	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
246195004199	RNA binding site [nucleotide binding]; other site
246195004200	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
246195004201	RNA binding site [nucleotide binding]; other site
246195004202	Protein of unknown function (DUF1318); Region: DUF1318; cl01547
246195004203	Domain of unknown function (DUF1820); Region: DUF1820; pfam08850
246195004204	Rhomboid family; Region: Rhomboid; pfam01694
246195004205	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150
246195004206	homotrimer interaction site [polypeptide binding]; other site
246195004207	putative active site [active]
246195004208	methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252
246195004209	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
246195004210	substrate binding site [chemical binding]; other site
246195004211	active site
246195004212	pyruvate formate lyase-activating enzyme 1; Provisional; Region: pflA; PRK11145
246195004213	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
246195004214	FeS/SAM binding site; other site
246195004215	formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255
246195004216	Pyruvate formate lyase 1; Region: PFL1; cd01678
246195004217	coenzyme A binding site [chemical binding]; other site
246195004218	active site
246195004219	catalytic residues [active]
246195004220	glycine loop; other site
246195004221	ornithine carbamoyltransferase; Validated; Region: PRK02102
246195004222	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
246195004223	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
246195004224	flavoprotein, HI0933 family; Region: TIGR00275
246195004225	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
246195004226	Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647
246195004227	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
246195004228	active site
246195004229	motif I; other site
246195004230	motif II; other site
246195004231	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
246195004232	Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770
246195004233	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
246195004234	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
246195004235	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
246195004236	ring oligomerisation interface [polypeptide binding]; other site
246195004237	ATP/Mg binding site [chemical binding]; other site
246195004238	stacking interactions; other site
246195004239	hinge regions; other site
246195004240	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
246195004241	oligomerisation interface [polypeptide binding]; other site
246195004242	mobile loop; other site
246195004243	roof hairpin; other site
246195004244	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
246195004245	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
246195004246	Probable transposase; Region: OrfB_IS605; pfam01385
246195004247	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
246195004248	Transposase IS200 like; Region: Y1_Tnp; pfam01797
246195004249	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
246195004250	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
246195004251	substrate binding pocket [chemical binding]; other site
246195004252	membrane-bound complex binding site; other site
246195004253	hinge residues; other site
246195004254	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
246195004255	catalytic core [active]
246195004256	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
246195004257	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
246195004258	substrate binding pocket [chemical binding]; other site
246195004259	membrane-bound complex binding site; other site
246195004260	hinge residues; other site
246195004261	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
246195004262	active site
246195004263	HslU subunit interaction site [polypeptide binding]; other site
246195004264	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
246195004265	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
246195004266	Walker A motif; other site
246195004267	ATP binding site [chemical binding]; other site
246195004268	AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724
246195004269	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
246195004270	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
246195004271	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
246195004272	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
246195004273	Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814
246195004274	threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672
246195004275	peptidase T; Region: peptidase-T; TIGR01882
246195004276	M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892
246195004277	metal binding site [ion binding]; metal-binding site
246195004278	dimer interface [polypeptide binding]; other site
246195004279	dipeptidyl carboxypeptidase II; Provisional; Region: PRK10280
246195004280	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
246195004281	active site
246195004282	Zn binding site [ion binding]; other site
246195004283	dipeptidyl carboxypeptidase II; Provisional; Region: PRK10280
246195004284	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
246195004285	active site
246195004286	Zn binding site [ion binding]; other site
246195004287	C4-dicarboxylate transporter DcuC; Provisional; Region: dcuC; PRK10654
246195004288	C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606
246195004289	C4-dicarboxylate transporter DcuC; Provisional; Region: dcuC; PRK10654
246195004290	C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606