-- dump date 20140619_065304 -- class Genbank::misc_feature -- table misc_feature_note -- id note 198628000001 FMN-binding protein MioC; Provisional; Region: PRK09004 198628000002 DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179 198628000003 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 198628000004 putative DNA binding site [nucleotide binding]; other site 198628000005 putative Zn2+ binding site [ion binding]; other site 198628000006 AsnC family; Region: AsnC_trans_reg; pfam01037 198628000007 hypothetical protein; Provisional; Region: yieM; PRK10997 198628000008 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 198628000009 metal ion-dependent adhesion site (MIDAS); other site 198628000010 regulatory ATPase RavA; Provisional; Region: PRK13531 198628000011 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 198628000012 Walker A motif; other site 198628000013 ATP binding site [chemical binding]; other site 198628000014 Walker B motif; other site 198628000015 arginine finger; other site 198628000016 Protein of unknown function (DUF3763); Region: DUF3763; pfam12592 198628000017 potassium transport protein Kup; Provisional; Region: trkD; PRK10745 198628000018 potassium uptake protein; Region: kup; TIGR00794 198628000019 D-ribose pyranase; Provisional; Region: PRK11797 198628000020 D-ribose transporter ATP binding protein; Provisional; Region: PRK10762 198628000021 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 198628000022 Walker A/P-loop; other site 198628000023 ATP binding site [chemical binding]; other site 198628000024 Q-loop/lid; other site 198628000025 ABC transporter signature motif; other site 198628000026 Walker B; other site 198628000027 D-loop; other site 198628000028 H-loop/switch region; other site 198628000029 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 198628000030 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 198628000031 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 198628000032 TM-ABC transporter signature motif; other site 198628000033 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 198628000034 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 198628000035 ligand binding site [chemical binding]; other site 198628000036 dimerization interface [polypeptide binding]; other site 198628000037 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 198628000038 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 198628000039 substrate binding site [chemical binding]; other site 198628000040 dimer interface [polypeptide binding]; other site 198628000041 ATP binding site [chemical binding]; other site 198628000042 transcriptional repressor RbsR; Provisional; Region: PRK10423 198628000043 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 198628000044 DNA binding site [nucleotide binding] 198628000045 domain linker motif; other site 198628000046 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 198628000047 dimerization interface [polypeptide binding]; other site 198628000048 ligand binding site [chemical binding]; other site 198628000049 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 198628000050 Walker A motif; other site 198628000051 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 198628000052 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 198628000053 GTP binding site; other site 198628000054 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3084 198628000055 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 198628000056 serine/threonine protein kinase; Provisional; Region: PRK11768 198628000057 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 198628000058 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 198628000059 catalytic residues [active] 198628000060 hinge region; other site 198628000061 alpha helical domain; other site 198628000062 DNA polymerase I; Provisional; Region: PRK05755 198628000063 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 198628000064 active site 198628000065 metal binding site 1 [ion binding]; metal-binding site 198628000066 putative 5' ssDNA interaction site; other site 198628000067 metal binding site 3; metal-binding site 198628000068 metal binding site 2 [ion binding]; metal-binding site 198628000069 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 198628000070 putative DNA binding site [nucleotide binding]; other site 198628000071 putative metal binding site [ion binding]; other site 198628000072 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 198628000073 active site 198628000074 catalytic site [active] 198628000075 substrate binding site [chemical binding]; other site 198628000076 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 198628000077 active site 198628000078 DNA binding site [nucleotide binding] 198628000079 catalytic site [active] 198628000080 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 198628000081 G1 box; other site 198628000082 GTP/Mg2+ binding site [chemical binding]; other site 198628000083 Switch I region; other site 198628000084 G2 box; other site 198628000085 G3 box; other site 198628000086 Switch II region; other site 198628000087 G4 box; other site 198628000088 G5 box; other site 198628000089 Der GTPase activator; Provisional; Region: PRK05244 198628000090 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 198628000091 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 198628000092 FeS/SAM binding site; other site 198628000093 HemN C-terminal domain; Region: HemN_C; pfam06969 198628000094 nitrogen regulation protein NR(I); Provisional; Region: glnG; PRK10923 198628000095 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 198628000096 active site 198628000097 phosphorylation site [posttranslational modification] 198628000098 intermolecular recognition site; other site 198628000099 dimerization interface [polypeptide binding]; other site 198628000100 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 198628000101 Walker A motif; other site 198628000102 ATP binding site [chemical binding]; other site 198628000103 Walker B motif; other site 198628000104 arginine finger; other site 198628000105 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 198628000106 nitrogen regulation protein NR(II); Provisional; Region: glnL; PRK11073 198628000107 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 198628000108 dimer interface [polypeptide binding]; other site 198628000109 phosphorylation site [posttranslational modification] 198628000110 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 198628000111 ATP binding site [chemical binding]; other site 198628000112 Mg2+ binding site [ion binding]; other site 198628000113 G-X-G motif; other site 198628000114 glutamine synthetase; Provisional; Region: glnA; PRK09469 198628000115 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 198628000116 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 198628000117 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 198628000118 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 198628000119 G1 box; other site 198628000120 putative GEF interaction site [polypeptide binding]; other site 198628000121 GTP/Mg2+ binding site [chemical binding]; other site 198628000122 Switch I region; other site 198628000123 G2 box; other site 198628000124 G3 box; other site 198628000125 Switch II region; other site 198628000126 G4 box; other site 198628000127 G5 box; other site 198628000128 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 198628000129 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 198628000130 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 198628000131 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 198628000132 motif II; other site 198628000133 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 198628000134 putative active site [active] 198628000135 dimerization interface [polypeptide binding]; other site 198628000136 putative tRNAtyr binding site [nucleotide binding]; other site 198628000137 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 198628000138 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 198628000139 Coenzyme A binding pocket [chemical binding]; other site 198628000140 Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; pfam09500 198628000141 AsmA family; Region: AsmA; pfam05170 198628000142 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 198628000143 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 198628000144 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 198628000145 Y-family of DNA polymerases; Region: PolY; cl12025 198628000146 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 198628000147 generic binding surface II; other site 198628000148 ssDNA binding site; other site 198628000149 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 198628000150 ATP binding site [chemical binding]; other site 198628000151 putative Mg++ binding site [ion binding]; other site 198628000152 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 198628000153 nucleotide binding region [chemical binding]; other site 198628000154 ATP-binding site [chemical binding]; other site 198628000155 tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081 198628000156 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 198628000157 SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105 198628000158 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092 198628000159 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 198628000160 Zn2+ binding site [ion binding]; other site 198628000161 Mg2+ binding site [ion binding]; other site 198628000162 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 198628000163 synthetase active site [active] 198628000164 NTP binding site [chemical binding]; other site 198628000165 metal binding site [ion binding]; metal-binding site 198628000166 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 198628000167 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 198628000168 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 198628000169 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 198628000170 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 198628000171 catalytic site [active] 198628000172 G-X2-G-X-G-K; other site 198628000173 NAD-dependent DNA ligase LigB; Reviewed; Region: ligB; PRK08097 198628000174 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295 198628000175 nucleotide binding pocket [chemical binding]; other site 198628000176 K-X-D-G motif; other site 198628000177 catalytic site [active] 198628000178 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 198628000179 phosphoethanolamine transferase; Provisional; Region: PRK11560 198628000180 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 198628000181 Sulfatase; Region: Sulfatase; pfam00884 198628000182 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 198628000183 TPR motif; other site 198628000184 binding surface 198628000185 short chain dehydrogenase; Provisional; Region: PRK09072 198628000186 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 198628000187 NAD(P) binding site [chemical binding]; other site 198628000188 active site 198628000189 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl17299 198628000190 heme binding pocket [chemical binding]; other site 198628000191 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198628000192 Major Facilitator Superfamily; Region: MFS_1; pfam07690 198628000193 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198628000194 Major Facilitator Superfamily; Region: MFS_1; pfam07690 198628000195 Transcriptional regulator [Transcription]; Region: LysR; COG0583 198628000196 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 198628000197 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 198628000198 putative effector binding pocket; other site 198628000199 dimerization interface [polypeptide binding]; other site 198628000200 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198628000201 putative substrate translocation pore; other site 198628000202 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 198628000203 glucose-1-phosphatase/inositol phosphatase; Provisional; Region: PRK10173 198628000204 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 198628000205 catalytic core [active] 198628000206 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 198628000207 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198628000208 dimer interface [polypeptide binding]; other site 198628000209 conserved gate region; other site 198628000210 putative PBP binding loops; other site 198628000211 ABC-ATPase subunit interface; other site 198628000212 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 198628000213 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198628000214 dimer interface [polypeptide binding]; other site 198628000215 conserved gate region; other site 198628000216 putative PBP binding loops; other site 198628000217 ABC-ATPase subunit interface; other site 198628000218 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 198628000219 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 198628000220 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 198628000221 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 198628000222 active site 198628000223 CobD/Cbib protein; Region: CobD_Cbib; cl00561 198628000224 Double zinc ribbon; Region: DZR; pfam12773 198628000225 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 198628000226 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 198628000227 Coenzyme A binding pocket [chemical binding]; other site 198628000228 D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine to pyruvate and ammonia. D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447 198628000229 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 198628000230 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 198628000231 catalytic residue [active] 198628000232 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 198628000233 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 198628000234 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 198628000235 nucleotide binding site [chemical binding]; other site 198628000236 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 198628000237 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198628000238 dimer interface [polypeptide binding]; other site 198628000239 conserved gate region; other site 198628000240 putative PBP binding loops; other site 198628000241 ABC-ATPase subunit interface; other site 198628000242 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 198628000243 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198628000244 dimer interface [polypeptide binding]; other site 198628000245 conserved gate region; other site 198628000246 putative PBP binding loops; other site 198628000247 ABC-ATPase subunit interface; other site 198628000248 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 198628000249 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 198628000250 Walker A/P-loop; other site 198628000251 ATP binding site [chemical binding]; other site 198628000252 Q-loop/lid; other site 198628000253 ABC transporter signature motif; other site 198628000254 Walker B; other site 198628000255 D-loop; other site 198628000256 H-loop/switch region; other site 198628000257 TOBE domain; Region: TOBE_2; pfam08402 198628000258 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 198628000259 putative catalytic site [active] 198628000260 putative metal binding site [ion binding]; other site 198628000261 putative phosphate binding site [ion binding]; other site 198628000262 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 198628000263 TIGR02646 family protein; Region: TIGR02646 198628000264 AAA domain; Region: AAA_23; pfam13476 198628000265 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 198628000266 Walker A/P-loop; other site 198628000267 ATP binding site [chemical binding]; other site 198628000268 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 198628000269 Q-loop/lid; other site 198628000270 ABC transporter signature motif; other site 198628000271 Walker B; other site 198628000272 D-loop; other site 198628000273 H-loop/switch region; other site 198628000274 Predicted flavoproteins [General function prediction only]; Region: COG2081 198628000275 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 198628000276 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 198628000277 universal stress protein UspB; Provisional; Region: PRK04960 198628000278 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 198628000279 Ligand Binding Site [chemical binding]; other site 198628000280 Cache domain; Region: Cache_1; pfam02743 198628000281 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 198628000282 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 198628000283 dimer interface [polypeptide binding]; other site 198628000284 putative CheW interface [polypeptide binding]; other site 198628000285 sugar phosphate phosphatase; Provisional; Region: PRK10513 198628000286 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 198628000287 active site 198628000288 motif I; other site 198628000289 motif II; other site 198628000290 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 198628000291 mannonate dehydratase; Provisional; Region: PRK03906 198628000292 mannonate dehydratase; Region: uxuA; TIGR00695 198628000293 Transcriptional regulators [Transcription]; Region: FadR; COG2186 198628000294 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 198628000295 DNA-binding site [nucleotide binding]; DNA binding site 198628000296 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 198628000297 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 198628000298 Transposase; Region: DEDD_Tnp_IS110; pfam01548 198628000299 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 198628000300 Protein of unknown function (DUF1471); Region: DUF1471; cl11507 198628000301 Protein of unknown function (DUF3748); Region: DUF3748; pfam12566 198628000302 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 198628000303 Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_YpCarbK_like; cd07782 198628000304 Ribulose kinase [Energy production and conversion]; Region: AraB; COG1069 198628000305 N- and C-terminal domain interface [polypeptide binding]; other site 198628000306 active site 198628000307 MgATP binding site [chemical binding]; other site 198628000308 catalytic site [active] 198628000309 metal binding site [ion binding]; metal-binding site 198628000310 carbohydrate binding site [chemical binding]; other site 198628000311 putative homodimer interface [polypeptide binding]; other site 198628000312 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 198628000313 hexamer (dimer of trimers) interface [polypeptide binding]; other site 198628000314 substrate binding site [chemical binding]; other site 198628000315 trimer interface [polypeptide binding]; other site 198628000316 Mn binding site [ion binding]; other site 198628000317 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 198628000318 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 198628000319 inhibitor site; inhibition site 198628000320 active site 198628000321 dimer interface [polypeptide binding]; other site 198628000322 catalytic residue [active] 198628000323 Predicted neuraminidase (sialidase) [Carbohydrate transport and metabolism]; Region: COG4692 198628000324 BNR repeat-like domain; Region: BNR_2; pfam13088 198628000325 shikimate transporter; Provisional; Region: PRK09952 198628000326 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198628000327 putative substrate translocation pore; other site 198628000328 D-fructose-responsive transcription factor; Region: fruct_sucro_rep; TIGR02417 198628000329 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 198628000330 DNA binding site [nucleotide binding] 198628000331 domain linker motif; other site 198628000332 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 198628000333 dimerization interface [polypeptide binding]; other site 198628000334 ligand binding site [chemical binding]; other site 198628000335 Protein of unknown function (DUF1375); Region: DUF1375; cl11456 198628000336 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 198628000337 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 198628000338 putative dimer interface [polypeptide binding]; other site 198628000339 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 198628000340 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 198628000341 putative dimer interface [polypeptide binding]; other site 198628000342 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 198628000343 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 198628000344 transmembrane helices; other site 198628000345 sensory histidine kinase DcuS; Provisional; Region: PRK11086 198628000346 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 198628000347 ATP binding site [chemical binding]; other site 198628000348 Mg2+ binding site [ion binding]; other site 198628000349 G-X-G motif; other site 198628000350 DNA-binding transcriptional activator DcuR; Provisional; Region: PRK10430 198628000351 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 198628000352 active site 198628000353 phosphorylation site [posttranslational modification] 198628000354 intermolecular recognition site; other site 198628000355 dimerization interface [polypeptide binding]; other site 198628000356 2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390 198628000357 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 198628000358 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 198628000359 peptide binding site [polypeptide binding]; other site 198628000360 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 198628000361 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198628000362 dimer interface [polypeptide binding]; other site 198628000363 conserved gate region; other site 198628000364 putative PBP binding loops; other site 198628000365 ABC-ATPase subunit interface; other site 198628000366 dipeptide transporter; Provisional; Region: PRK10913 198628000367 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 198628000368 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198628000369 dimer interface [polypeptide binding]; other site 198628000370 conserved gate region; other site 198628000371 putative PBP binding loops; other site 198628000372 ABC-ATPase subunit interface; other site 198628000373 dipeptide transporter ATP-binding subunit; Provisional; Region: dppD; PRK11022 198628000374 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 198628000375 Walker A/P-loop; other site 198628000376 ATP binding site [chemical binding]; other site 198628000377 Q-loop/lid; other site 198628000378 ABC transporter signature motif; other site 198628000379 Walker B; other site 198628000380 D-loop; other site 198628000381 H-loop/switch region; other site 198628000382 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 198628000383 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 198628000384 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 198628000385 Walker A/P-loop; other site 198628000386 ATP binding site [chemical binding]; other site 198628000387 Q-loop/lid; other site 198628000388 ABC transporter signature motif; other site 198628000389 Walker B; other site 198628000390 D-loop; other site 198628000391 H-loop/switch region; other site 198628000392 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 198628000393 Protein of unknown function (DUF3828); Region: DUF3828; pfam12883 198628000394 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 198628000395 non-specific DNA binding site [nucleotide binding]; other site 198628000396 salt bridge; other site 198628000397 sequence-specific DNA binding site [nucleotide binding]; other site 198628000398 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 198628000399 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 198628000400 DNA-binding site [nucleotide binding]; DNA binding site 198628000401 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 198628000402 pyridoxal 5'-phosphate binding site [chemical binding]; other site 198628000403 homodimer interface [polypeptide binding]; other site 198628000404 catalytic residue [active] 198628000405 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 198628000406 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_11; cd07261 198628000407 putative dimer interface [polypeptide binding]; other site 198628000408 HTH domain; Region: HTH_11; pfam08279 198628000409 Predicted transcriptional regulator [Transcription]; Region: COG2378 198628000410 WYL domain; Region: WYL; pfam13280 198628000411 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 198628000412 EamA-like transporter family; Region: EamA; pfam00892 198628000413 oligosaccharyl transferase, archaeosortase A system-associated; Region: archaeo_STT3; TIGR04154 198628000414 cellulose synthase operon protein YhjQ; Region: cellulose_yhjQ; TIGR03371 198628000415 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 198628000416 P-loop; other site 198628000417 Magnesium ion binding site [ion binding]; other site 198628000418 cellulose synthase catalytic subunit (UDP-forming); Region: CelA; TIGR03030 198628000419 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 198628000420 DXD motif; other site 198628000421 PilZ domain; Region: PilZ; pfam07238 198628000422 cellulose synthase regulator protein; Provisional; Region: PRK11114 198628000423 TPR repeat; Region: TPR_11; pfam13414 198628000424 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 198628000425 TPR motif; other site 198628000426 binding surface 198628000427 Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420 198628000428 Cellulose synthase subunit D; Region: Cellsynth_D; pfam03500 198628000429 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; pfam01270 198628000430 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 198628000431 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 198628000432 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 198628000433 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 198628000434 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 198628000435 Virulence protein [General function prediction only]; Region: COG3943 198628000436 Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310 198628000437 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 198628000438 RelB antitoxin; Region: RelB; cl01171 198628000439 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 198628000440 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 198628000441 substrate binding site [chemical binding]; other site 198628000442 ATP binding site [chemical binding]; other site 198628000443 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491 198628000444 active site 1 [active] 198628000445 dimer interface [polypeptide binding]; other site 198628000446 hexamer interface [polypeptide binding]; other site 198628000447 active site 2 [active] 198628000448 inner membrane protein YhjD; Region: TIGR00766 198628000449 major facilitator superfamily transporter; Provisional; Region: PRK05122 198628000450 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198628000451 putative substrate translocation pore; other site 198628000452 hypothetical protein; Provisional; Region: PRK11615 198628000453 hypothetical protein; Provisional; Region: PRK11212 198628000454 SirA (also known as UvrY, and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A...; Region: SirA; cd03423 198628000455 CPxP motif; other site 198628000456 Predicted membrane protein [Function unknown]; Region: COG3714 198628000457 Domain of unknown function (DUF1820); Region: DUF1820; cl11545 198628000458 hypothetical protein; Provisional; Region: PRK10910 198628000459 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 198628000460 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 198628000461 S-adenosylmethionine binding site [chemical binding]; other site 198628000462 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 198628000463 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 198628000464 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 198628000465 P loop; other site 198628000466 GTP binding site [chemical binding]; other site 198628000467 cell division protein FtsE; Provisional; Region: PRK10908 198628000468 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 198628000469 Walker A/P-loop; other site 198628000470 ATP binding site [chemical binding]; other site 198628000471 Q-loop/lid; other site 198628000472 ABC transporter signature motif; other site 198628000473 Walker B; other site 198628000474 D-loop; other site 198628000475 H-loop/switch region; other site 198628000476 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 198628000477 putative protein insertion permease FtsX; Region: ftsX; TIGR00439 198628000478 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 198628000479 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 198628000480 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 198628000481 DNA binding residues [nucleotide binding] 198628000482 Acetyltransferase (GNAT) domain; Region: DUF3749; pfam12568 198628000483 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 198628000484 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 198628000485 dimerization interface [polypeptide binding]; other site 198628000486 ligand binding site [chemical binding]; other site 198628000487 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 198628000488 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 198628000489 TM-ABC transporter signature motif; other site 198628000490 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 198628000491 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 198628000492 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 198628000493 TM-ABC transporter signature motif; other site 198628000494 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 198628000495 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 198628000496 Walker A/P-loop; other site 198628000497 ATP binding site [chemical binding]; other site 198628000498 Q-loop/lid; other site 198628000499 ABC transporter signature motif; other site 198628000500 Walker B; other site 198628000501 D-loop; other site 198628000502 H-loop/switch region; other site 198628000503 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livF; PRK11614 198628000504 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 198628000505 Walker A/P-loop; other site 198628000506 ATP binding site [chemical binding]; other site 198628000507 Q-loop/lid; other site 198628000508 ABC transporter signature motif; other site 198628000509 Walker B; other site 198628000510 D-loop; other site 198628000511 H-loop/switch region; other site 198628000512 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 198628000513 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 198628000514 pyridoxal 5'-phosphate binding site [chemical binding]; other site 198628000515 homodimer interface [polypeptide binding]; other site 198628000516 catalytic residue [active] 198628000517 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 198628000518 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 198628000519 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 198628000520 dimer interface [polypeptide binding]; other site 198628000521 putative CheW interface [polypeptide binding]; other site 198628000522 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 198628000523 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 198628000524 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 198628000525 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 198628000526 dimer interface [polypeptide binding]; other site 198628000527 putative CheW interface [polypeptide binding]; other site 198628000528 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 198628000529 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 198628000530 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 198628000531 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 198628000532 dimer interface [polypeptide binding]; other site 198628000533 putative CheW interface [polypeptide binding]; other site 198628000534 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 198628000535 HAMP domain; Region: HAMP; pfam00672 198628000536 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 198628000537 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 198628000538 dimer interface [polypeptide binding]; other site 198628000539 putative CheW interface [polypeptide binding]; other site 198628000540 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 198628000541 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 198628000542 dimer interface [polypeptide binding]; other site 198628000543 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 198628000544 putative CheW interface [polypeptide binding]; other site 198628000545 glycerol-3-phosphate transporter periplasmic binding protein; Provisional; Region: PRK10974 198628000546 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 198628000547 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198628000548 dimer interface [polypeptide binding]; other site 198628000549 conserved gate region; other site 198628000550 putative PBP binding loops; other site 198628000551 ABC-ATPase subunit interface; other site 198628000552 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 198628000553 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198628000554 dimer interface [polypeptide binding]; other site 198628000555 conserved gate region; other site 198628000556 putative PBP binding loops; other site 198628000557 ABC-ATPase subunit interface; other site 198628000558 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 198628000559 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 198628000560 Walker A/P-loop; other site 198628000561 ATP binding site [chemical binding]; other site 198628000562 Q-loop/lid; other site 198628000563 ABC transporter signature motif; other site 198628000564 Walker B; other site 198628000565 D-loop; other site 198628000566 H-loop/switch region; other site 198628000567 TOBE domain; Region: TOBE_2; pfam08402 198628000568 cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454 198628000569 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 198628000570 putative active site [active] 198628000571 catalytic site [active] 198628000572 putative metal binding site [ion binding]; other site 198628000573 Predicted permeases [General function prediction only]; Region: COG0679 198628000574 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 198628000575 AAA domain; Region: AAA_17; pfam13207 198628000576 topology modulation protein; Provisional; Region: PRK07261 198628000577 Protein of unknown function (DUF3142); Region: DUF3142; pfam11340 198628000578 two-component sensor protein; Provisional; Region: cpxA; PRK09470 198628000579 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 198628000580 dimerization interface [polypeptide binding]; other site 198628000581 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 198628000582 dimer interface [polypeptide binding]; other site 198628000583 phosphorylation site [posttranslational modification] 198628000584 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 198628000585 ATP binding site [chemical binding]; other site 198628000586 Mg2+ binding site [ion binding]; other site 198628000587 G-X-G motif; other site 198628000588 DNA-binding transcriptional regulator CpxR; Provisional; Region: PRK10955 198628000589 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 198628000590 active site 198628000591 intermolecular recognition site; other site 198628000592 dimerization interface [polypeptide binding]; other site 198628000593 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 198628000594 DNA binding site [nucleotide binding] 198628000595 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 198628000596 dimer interface [polypeptide binding]; other site 198628000597 Phage tail-collar fibre protein; Region: DUF3751; pfam12571 198628000598 Phage tail-collar fibre protein; Region: DUF3751; pfam12571 198628000599 Phage tail-collar fibre protein; Region: DUF3751; pfam12571 198628000600 Phage Tail Collar Domain; Region: Collar; pfam07484 198628000601 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 198628000602 Phage tail-collar fibre protein; Region: DUF3751; pfam12571 198628000603 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 198628000604 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily requires a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_26; cd04685 198628000605 nudix motif; other site 198628000606 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 198628000607 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 198628000608 non-specific DNA binding site [nucleotide binding]; other site 198628000609 salt bridge; other site 198628000610 sequence-specific DNA binding site [nucleotide binding]; other site 198628000611 2TM domain; Region: 2TM; pfam13239 198628000612 ferrous iron efflux protein F; Reviewed; Region: fieF; PRK09509 198628000613 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 198628000614 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 198628000615 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 198628000616 active site 198628000617 ADP/pyrophosphate binding site [chemical binding]; other site 198628000618 dimerization interface [polypeptide binding]; other site 198628000619 allosteric effector site; other site 198628000620 fructose-1,6-bisphosphate binding site; other site 198628000621 N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573 198628000622 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 198628000623 putative active site; other site 198628000624 catalytic triad [active] 198628000625 putative dimer interface [polypeptide binding]; other site 198628000626 agmatine deiminase; Provisional; Region: PRK13551 198628000627 agmatine deiminase; Region: agmatine_aguA; TIGR03380 198628000628 alkaline phosphatase; Provisional; Region: PRK10518 198628000629 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 198628000630 dimer interface [polypeptide binding]; other site 198628000631 active site 198628000632 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 198628000633 triosephosphate isomerase; Provisional; Region: PRK14567 198628000634 substrate binding site [chemical binding]; other site 198628000635 dimer interface [polypeptide binding]; other site 198628000636 catalytic triad [active] 198628000637 Protein of unknown function (DUF1454); Region: DUF1454; pfam07305 198628000638 Predicted membrane protein [Function unknown]; Region: COG3152 198628000639 ferredoxin-NADP reductase; Provisional; Region: PRK10926 198628000640 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 198628000641 FAD binding pocket [chemical binding]; other site 198628000642 FAD binding motif [chemical binding]; other site 198628000643 phosphate binding motif [ion binding]; other site 198628000644 beta-alpha-beta structure motif; other site 198628000645 NAD binding pocket [chemical binding]; other site 198628000646 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 198628000647 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 198628000648 putative active site [active] 198628000649 glycerol kinase; Provisional; Region: glpK; PRK00047 198628000650 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 198628000651 N- and C-terminal domain interface [polypeptide binding]; other site 198628000652 active site 198628000653 MgATP binding site [chemical binding]; other site 198628000654 catalytic site [active] 198628000655 metal binding site [ion binding]; metal-binding site 198628000656 glycerol binding site [chemical binding]; other site 198628000657 homotetramer interface [polypeptide binding]; other site 198628000658 homodimer interface [polypeptide binding]; other site 198628000659 FBP binding site [chemical binding]; other site 198628000660 protein IIAGlc interface [polypeptide binding]; other site 198628000661 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 198628000662 amphipathic channel; other site 198628000663 Asn-Pro-Ala signature motifs; other site 198628000664 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3074 198628000665 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 198628000666 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 198628000667 UbiA prenyltransferase family; Region: UbiA; pfam01040 198628000668 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 198628000669 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 198628000670 Walker A motif; other site 198628000671 ATP binding site [chemical binding]; other site 198628000672 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 198628000673 Walker B motif; other site 198628000674 arginine finger; other site 198628000675 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 198628000676 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 198628000677 active site 198628000678 HslU subunit interaction site [polypeptide binding]; other site 198628000679 Cell division protein [Cell division and chromosome partitioning]; Region: FtsN; COG3087 198628000680 Sporulation related domain; Region: SPOR; cl10051 198628000681 Sporulation related domain; Region: SPOR; cl10051 198628000682 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 198628000683 DNA binding site [nucleotide binding] 198628000684 DNA-binding transcriptional regulator CytR; Provisional; Region: PRK11041 198628000685 domain linker motif; other site 198628000686 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 198628000687 dimerization interface [polypeptide binding]; other site 198628000688 ligand binding site [chemical binding]; other site 198628000689 primosome assembly protein PriA; Validated; Region: PRK05580 198628000690 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 198628000691 ATP binding site [chemical binding]; other site 198628000692 putative Mg++ binding site [ion binding]; other site 198628000693 helicase superfamily c-terminal domain; Region: HELICc; smart00490 198628000694 ATP-binding site [chemical binding]; other site 198628000695 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 198628000696 Met Repressor, MetJ. MetJ is a bacterial regulatory protein that uses S-adenosylmethionine (SAM) as a corepressor to regulate the production of Methionine. MetJ binds arrays of two to five adjacent copies of an eight base-pair 'metbox'...; Region: Met_repressor_MetJ; cd00490 198628000697 dimerization interface [polypeptide binding]; other site 198628000698 DNA binding site [nucleotide binding] 198628000699 corepressor binding sites; other site 198628000700 cystathionine gamma-synthase; Provisional; Region: PRK08045 198628000701 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 198628000702 homodimer interface [polypeptide binding]; other site 198628000703 substrate-cofactor binding pocket; other site 198628000704 pyridoxal 5'-phosphate binding site [chemical binding]; other site 198628000705 catalytic residue [active] 198628000706 bifunctional aspartate kinase II/homoserine dehydrogenase II; Provisional; Region: metL; PRK09466 198628000707 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 198628000708 putative catalytic residues [active] 198628000709 putative nucleotide binding site [chemical binding]; other site 198628000710 putative aspartate binding site [chemical binding]; other site 198628000711 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 198628000712 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 198628000713 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 198628000714 FAD binding site [chemical binding]; other site 198628000715 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 198628000716 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 198628000717 catalytic triad [active] 198628000718 dimer interface [polypeptide binding]; other site 198628000719 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 198628000720 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 198628000721 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 198628000722 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 198628000723 dimerization interface [polypeptide binding]; other site 198628000724 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 198628000725 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 198628000726 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 198628000727 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 198628000728 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 198628000729 hypothetical protein; Provisional; Region: PRK11056 198628000730 tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031 198628000731 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 198628000732 S-adenosylmethionine binding site [chemical binding]; other site 198628000733 vitamin B12/cobalamin outer membrane transporter; Provisional; Region: btuB; PRK10641 198628000734 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 198628000735 N-terminal plug; other site 198628000736 ligand-binding site [chemical binding]; other site 198628000737 glutamate racemase; Provisional; Region: PRK00865 198628000738 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 198628000739 FAD binding domain; Region: FAD_binding_4; pfam01565 198628000740 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 198628000741 Biotin operon repressor [Transcription]; Region: BirA; COG1654 198628000742 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 198628000743 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 198628000744 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 198628000745 pantothenate kinase; Provisional; Region: PRK05439 198628000746 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 198628000747 ATP-binding site [chemical binding]; other site 198628000748 CoA-binding site [chemical binding]; other site 198628000749 Mg2+-binding site [ion binding]; other site 198628000750 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 198628000751 Coenzyme A binding pocket [chemical binding]; other site 198628000752 elongation factor Tu; Reviewed; Region: PRK00049 198628000753 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 198628000754 G1 box; other site 198628000755 GEF interaction site [polypeptide binding]; other site 198628000756 GTP/Mg2+ binding site [chemical binding]; other site 198628000757 Switch I region; other site 198628000758 G2 box; other site 198628000759 G3 box; other site 198628000760 Switch II region; other site 198628000761 G4 box; other site 198628000762 G5 box; other site 198628000763 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 198628000764 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 198628000765 Antibiotic Binding Site [chemical binding]; other site 198628000766 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 198628000767 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 198628000768 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 198628000769 putative homodimer interface [polypeptide binding]; other site 198628000770 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 198628000771 heterodimer interface [polypeptide binding]; other site 198628000772 homodimer interface [polypeptide binding]; other site 198628000773 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 198628000774 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 198628000775 23S rRNA interface [nucleotide binding]; other site 198628000776 L7/L12 interface [polypeptide binding]; other site 198628000777 putative thiostrepton binding site; other site 198628000778 L25 interface [polypeptide binding]; other site 198628000779 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 198628000780 mRNA/rRNA interface [nucleotide binding]; other site 198628000781 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 198628000782 23S rRNA interface [nucleotide binding]; other site 198628000783 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 198628000784 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 198628000785 core dimer interface [polypeptide binding]; other site 198628000786 peripheral dimer interface [polypeptide binding]; other site 198628000787 L10 interface [polypeptide binding]; other site 198628000788 L11 interface [polypeptide binding]; other site 198628000789 putative EF-Tu interaction site [polypeptide binding]; other site 198628000790 putative EF-G interaction site [polypeptide binding]; other site 198628000791 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 198628000792 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 198628000793 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 198628000794 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 198628000795 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 198628000796 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 198628000797 RPB3 interaction site [polypeptide binding]; other site 198628000798 RPB1 interaction site [polypeptide binding]; other site 198628000799 RPB11 interaction site [polypeptide binding]; other site 198628000800 RPB10 interaction site [polypeptide binding]; other site 198628000801 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 198628000802 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 198628000803 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 198628000804 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 198628000805 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 198628000806 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 198628000807 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 198628000808 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 198628000809 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 198628000810 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 198628000811 DNA binding site [nucleotide binding] 198628000812 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 198628000813 Protein of unknown function (DUF1176); Region: DUF1176; pfam06674 198628000814 Domain of unknown function (DUF1127); Region: DUF1127; cl02276 198628000815 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 198628000816 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 198628000817 DNA-binding site [nucleotide binding]; DNA binding site 198628000818 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 198628000819 pyridoxal 5'-phosphate binding site [chemical binding]; other site 198628000820 homodimer interface [polypeptide binding]; other site 198628000821 catalytic residue [active] 198628000822 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 198628000823 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 198628000824 Moco binding site; other site 198628000825 metal coordination site [ion binding]; other site 198628000826 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 198628000827 Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) [Energy production and conversion]; Region: COG4117 198628000828 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 198628000829 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 198628000830 active site 198628000831 phosphorylation site [posttranslational modification] 198628000832 intermolecular recognition site; other site 198628000833 dimerization interface [polypeptide binding]; other site 198628000834 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 198628000835 DNA binding site [nucleotide binding] 198628000836 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 198628000837 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 198628000838 dimerization interface [polypeptide binding]; other site 198628000839 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 198628000840 dimer interface [polypeptide binding]; other site 198628000841 phosphorylation site [posttranslational modification] 198628000842 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 198628000843 ATP binding site [chemical binding]; other site 198628000844 Mg2+ binding site [ion binding]; other site 198628000845 G-X-G motif; other site 198628000846 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240 198628000847 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 198628000848 FeS/SAM binding site; other site 198628000849 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 198628000850 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 198628000851 ThiS interaction site; other site 198628000852 putative active site [active] 198628000853 tetramer interface [polypeptide binding]; other site 198628000854 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 198628000855 thiS-thiF/thiG interaction site; other site 198628000856 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 198628000857 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 198628000858 ATP binding site [chemical binding]; other site 198628000859 substrate interface [chemical binding]; other site 198628000860 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 198628000861 thiamine phosphate binding site [chemical binding]; other site 198628000862 active site 198628000863 pyrophosphate binding site [ion binding]; other site 198628000864 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 198628000865 ThiC-associated domain; Region: ThiC-associated; pfam13667 198628000866 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 198628000867 anti-RNA polymerase sigma 70 factor; Provisional; Region: PRK11718 198628000868 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 198628000869 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 198628000870 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 198628000871 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 198628000872 putative NADH binding site [chemical binding]; other site 198628000873 putative active site [active] 198628000874 nudix motif; other site 198628000875 putative metal binding site [ion binding]; other site 198628000876 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 198628000877 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 198628000878 substrate binding site [chemical binding]; other site 198628000879 active site 198628000880 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 198628000881 Active_site [active] 198628000882 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3068 198628000883 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 198628000884 IHF dimer interface [polypeptide binding]; other site 198628000885 IHF - DNA interface [nucleotide binding]; other site 198628000886 Protein of unknown function (DUF1481); Region: DUF1481; pfam07356 198628000887 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 198628000888 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 198628000889 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 198628000890 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 198628000891 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 198628000892 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 198628000893 purine monophosphate binding site [chemical binding]; other site 198628000894 dimer interface [polypeptide binding]; other site 198628000895 putative catalytic residues [active] 198628000896 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 198628000897 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 198628000898 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 198628000899 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 198628000900 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 198628000901 Walker A/P-loop; other site 198628000902 ATP binding site [chemical binding]; other site 198628000903 Q-loop/lid; other site 198628000904 ABC transporter signature motif; other site 198628000905 Walker B; other site 198628000906 D-loop; other site 198628000907 H-loop/switch region; other site 198628000908 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198628000909 dimer interface [polypeptide binding]; other site 198628000910 conserved gate region; other site 198628000911 putative PBP binding loops; other site 198628000912 ABC-ATPase subunit interface; other site 198628000913 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597 198628000914 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198628000915 conserved gate region; other site 198628000916 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198628000917 dimer interface [polypeptide binding]; other site 198628000918 conserved gate region; other site 198628000919 putative PBP binding loops; other site 198628000920 ABC-ATPase subunit interface; other site 198628000921 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 198628000922 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 198628000923 substrate binding pocket [chemical binding]; other site 198628000924 membrane-bound complex binding site; other site 198628000925 hinge residues; other site 198628000926 hypothetical protein; Validated; Region: PRK06186 198628000927 conserved cys residue [active] 198628000928 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 198628000929 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198628000930 dimer interface [polypeptide binding]; other site 198628000931 conserved gate region; other site 198628000932 putative PBP binding loops; other site 198628000933 ABC-ATPase subunit interface; other site 198628000934 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 198628000935 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 198628000936 substrate binding pocket [chemical binding]; other site 198628000937 membrane-bound complex binding site; other site 198628000938 hinge residues; other site 198628000939 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 198628000940 putative catalytic site [active] 198628000941 putative phosphate binding site [ion binding]; other site 198628000942 putative metal binding site [ion binding]; other site 198628000943 short chain dehydrogenase; Provisional; Region: PRK06482 198628000944 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 198628000945 NADP binding site [chemical binding]; other site 198628000946 active site 198628000947 steroid binding site; other site 198628000948 Transcriptional regulator [Transcription]; Region: LysR; COG0583 198628000949 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 198628000950 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 198628000951 putative effector binding pocket; other site 198628000952 putative dimerization interface [polypeptide binding]; other site 198628000953 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 198628000954 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 198628000955 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 198628000956 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 198628000957 putative NAD(P) binding site [chemical binding]; other site 198628000958 putative substrate binding site [chemical binding]; other site 198628000959 catalytic Zn binding site [ion binding]; other site 198628000960 structural Zn binding site [ion binding]; other site 198628000961 dimer interface [polypeptide binding]; other site 198628000962 integrase; Provisional; Region: PRK09692 198628000963 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 198628000964 active site 198628000965 Int/Topo IB signature motif; other site 198628000966 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; pfam05930 198628000967 D5 N terminal like; Region: D5_N; smart00885 198628000968 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 198628000969 Poxvirus D5 protein-like; Region: Pox_D5; pfam03288 198628000970 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 198628000971 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 198628000972 oligomer interface [polypeptide binding]; other site 198628000973 active site residues [active] 198628000974 Mu-like prophage major head subunit gpT; Region: Mu-like_gpT; cl01826 198628000975 Mu-like prophage major head subunit gpT; Region: Mu-like_gpT; cl01826 198628000976 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 198628000977 Protein of unknown function (DUF3500); Region: DUF3500; pfam12006 198628000978 phage tail tape measure protein, lambda family; Region: tape_meas_lam_C; TIGR01541 198628000979 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 198628000980 Factor for inversion stimulation Fis, transcriptional activator [Transcription / DNA replication, recombination, and repair]; Region: Fis; COG2901 198628000981 global DNA-binding transcriptional dual regulator Fis; Provisional; Region: fis; PRK00430 198628000982 tRNA-dihydrouridine synthase B; Provisional; Region: PRK10415 198628000983 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 198628000984 FMN binding site [chemical binding]; other site 198628000985 active site 198628000986 catalytic residues [active] 198628000987 substrate binding site [chemical binding]; other site 198628000988 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 198628000989 Methyltransferase domain; Region: Methyltransf_18; pfam12847 198628000990 Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327 198628000991 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 198628000992 Na binding site [ion binding]; other site 198628000993 hypothetical protein; Provisional; Region: PRK10633 198628000994 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 198628000995 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 198628000996 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 198628000997 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 198628000998 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 198628000999 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 198628001000 carboxyltransferase (CT) interaction site; other site 198628001001 biotinylation site [posttranslational modification]; other site 198628001002 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 198628001003 Dehydroquinase class II; Region: DHquinase_II; pfam01220 198628001004 active site 198628001005 trimer interface [polypeptide binding]; other site 198628001006 dimer interface [polypeptide binding]; other site 198628001007 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 198628001008 TMAO/DMSO reductase; Reviewed; Region: PRK05363 198628001009 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 198628001010 Moco binding site; other site 198628001011 metal coordination site [ion binding]; other site 198628001012 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 198628001013 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 198628001014 NADP binding site [chemical binding]; other site 198628001015 dimer interface [polypeptide binding]; other site 198628001016 regulatory protein CsrD; Provisional; Region: PRK11059 198628001017 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 198628001018 metal binding site [ion binding]; metal-binding site 198628001019 active site 198628001020 I-site; other site 198628001021 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 198628001022 rod shape-determining protein MreB; Provisional; Region: PRK13927 198628001023 MreB and similar proteins; Region: MreB_like; cd10225 198628001024 nucleotide binding site [chemical binding]; other site 198628001025 Mg binding site [ion binding]; other site 198628001026 putative protofilament interaction site [polypeptide binding]; other site 198628001027 RodZ interaction site [polypeptide binding]; other site 198628001028 rod shape-determining protein MreC; Region: mreC; TIGR00219 198628001029 rod shape-determining protein MreC; Region: MreC; pfam04085 198628001030 rod shape-determining protein MreD; Provisional; Region: PRK11060 198628001031 Maf-like protein; Region: Maf; pfam02545 198628001032 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 198628001033 active site 198628001034 dimer interface [polypeptide binding]; other site 198628001035 ribonuclease G; Provisional; Region: PRK11712 198628001036 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 198628001037 homodimer interface [polypeptide binding]; other site 198628001038 oligonucleotide binding site [chemical binding]; other site 198628001039 hypothetical protein; Provisional; Region: PRK10899 198628001040 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 198628001041 protease TldD; Provisional; Region: tldD; PRK10735 198628001042 transcriptional regulator; Provisional; Region: PRK10632 198628001043 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 198628001044 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 198628001045 putative effector binding pocket; other site 198628001046 dimerization interface [polypeptide binding]; other site 198628001047 efflux system membrane protein; Provisional; Region: PRK11594 198628001048 p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559 198628001049 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 198628001050 HlyD family secretion protein; Region: HlyD_3; pfam13437 198628001051 p-hydroxybenzoic acid efflux subunit AaeB; Provisional; Region: PRK10631 198628001052 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 198628001053 Domain of Unknown Function (DUF1543); Region: DUF1543; pfam07566 198628001054 Domain of Unknown Function (DUF1543); Region: DUF1543; pfam07566 198628001055 LysE type translocator; Region: LysE; cl00565 198628001056 hypothetical protein; Provisional; Region: PRK05255 198628001057 peptidase PmbA; Provisional; Region: PRK11040 198628001058 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 198628001059 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 198628001060 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 198628001061 dimerization domain swap beta strand [polypeptide binding]; other site 198628001062 regulatory protein interface [polypeptide binding]; other site 198628001063 active site 198628001064 regulatory phosphorylation site [posttranslational modification]; other site 198628001065 P-loop ATPase protein family; Region: ATP_bind_2; pfam03668 198628001066 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 198628001067 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 198628001068 active site 198628001069 phosphorylation site [posttranslational modification] 198628001070 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 198628001071 30S subunit binding site; other site 198628001072 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 198628001073 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 198628001074 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 198628001075 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 198628001076 lipopolysaccharide ABC transporter ATP-binding protein; Provisional; Region: PRK10895 198628001077 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 198628001078 Walker A/P-loop; other site 198628001079 ATP binding site [chemical binding]; other site 198628001080 Q-loop/lid; other site 198628001081 ABC transporter signature motif; other site 198628001082 Walker B; other site 198628001083 D-loop; other site 198628001084 H-loop/switch region; other site 198628001085 lipopolysaccharide transport periplasmic protein LptA; Provisional; Region: PRK10894 198628001086 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1934 198628001087 lipopolysaccharide exporter periplasmic protein; Provisional; Region: PRK10893 198628001088 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 198628001089 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase; Provisional; Region: PRK09484 198628001090 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 198628001091 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 198628001092 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 198628001093 putative active site [active] 198628001094 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 198628001095 putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734 198628001096 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 198628001097 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 198628001098 putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831 198628001099 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 198628001100 Walker A/P-loop; other site 198628001101 ATP binding site [chemical binding]; other site 198628001102 Q-loop/lid; other site 198628001103 ABC transporter signature motif; other site 198628001104 Walker B; other site 198628001105 D-loop; other site 198628001106 H-loop/switch region; other site 198628001107 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 198628001108 conserved hypothetical integral membrane protein; Region: TIGR00056 198628001109 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 198628001110 mce related protein; Region: MCE; pfam02470 198628001111 ABC transporter periplasmic binding protein MlaC; Provisional; Region: PRK15117 198628001112 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 198628001113 anti sigma factor interaction site; other site 198628001114 regulatory phosphorylation site [posttranslational modification]; other site 198628001115 Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007 198628001116 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 198628001117 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 198628001118 hinge; other site 198628001119 active site 198628001120 serine endoprotease; Provisional; Region: PRK10898 198628001121 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 198628001122 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 198628001123 protein binding site [polypeptide binding]; other site 198628001124 serine endoprotease; Provisional; Region: PRK10139 198628001125 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 198628001126 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 198628001127 protein binding site [polypeptide binding]; other site 198628001128 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 198628001129 internal nonsense mutation split yhcB into two open reading frames, yhcB_1 and yhcB_2 198628001130 Predicted ATPase [General function prediction only]; Region: COG1485 198628001131 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 198628001132 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 198628001133 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 198628001134 23S rRNA interface [nucleotide binding]; other site 198628001135 L3 interface [polypeptide binding]; other site 198628001136 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 198628001137 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 198628001138 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 198628001139 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198628001140 putative substrate translocation pore; other site 198628001141 stringent starvation protein A; Provisional; Region: sspA; PRK09481 198628001142 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 198628001143 C-terminal domain interface [polypeptide binding]; other site 198628001144 putative GSH binding site (G-site) [chemical binding]; other site 198628001145 dimer interface [polypeptide binding]; other site 198628001146 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 198628001147 dimer interface [polypeptide binding]; other site 198628001148 N-terminal domain interface [polypeptide binding]; other site 198628001149 ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798 198628001150 Uncharacterized conserved protein [Function unknown]; Region: COG3791 198628001151 glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318 198628001152 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 198628001153 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 198628001154 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 198628001155 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 198628001156 active site 198628001157 dimer interface [polypeptide binding]; other site 198628001158 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 198628001159 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 198628001160 active site 198628001161 FMN binding site [chemical binding]; other site 198628001162 substrate binding site [chemical binding]; other site 198628001163 3Fe-4S cluster binding site [ion binding]; other site 198628001164 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 198628001165 domain interface; other site 198628001166 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 198628001167 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 198628001168 FeS/SAM binding site; other site 198628001169 internal nonsense mutation split arcB into two open reading frames, arcB_1 and arcB_2 198628001170 isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780 198628001171 Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133 198628001172 conserved cys residue [active] 198628001173 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 198628001174 Transglycosylase; Region: Transgly; cl17702 198628001175 Alginate lyase; Region: Alginate_lyase; pfam05426 198628001176 outer membrane lipoprotein; Provisional; Region: PRK11023 198628001177 BON domain; Region: BON; pfam04972 198628001178 BON domain; Region: BON; pfam04972 198628001179 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 198628001180 dimer interface [polypeptide binding]; other site 198628001181 active site 198628001182 hypothetical protein; Reviewed; Region: PRK12497 198628001183 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 198628001184 putative ligand binding site [chemical binding]; other site 198628001185 SAM-dependent 16S ribosomal RNA C1402 ribose 2'-O-methyltransferase; Provisional; Region: PRK14994 198628001186 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 198628001187 putative SAM binding site [chemical binding]; other site 198628001188 putative homodimer interface [polypeptide binding]; other site 198628001189 shikimate 5-dehydrogenase; Reviewed; Region: PRK12550 198628001190 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 198628001191 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 198628001192 shikimate binding site; other site 198628001193 NAD(P) binding site [chemical binding]; other site 198628001194 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 198628001195 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 198628001196 putative active site [active] 198628001197 metal binding site [ion binding]; metal-binding site 198628001198 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 198628001199 hypothetical protein; Provisional; Region: PRK11653 198628001200 outer membrane channel protein; Reviewed; Region: tolC; PRK09465 198628001201 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 198628001202 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 198628001203 dimer interface [polypeptide binding]; other site 198628001204 ADP-ribose binding site [chemical binding]; other site 198628001205 active site 198628001206 nudix motif; other site 198628001207 metal binding site [ion binding]; metal-binding site 198628001208 putative dehydrogenase; Provisional; Region: PRK11039 198628001209 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 198628001210 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 198628001211 active site 198628001212 metal binding site [ion binding]; metal-binding site 198628001213 hexamer interface [polypeptide binding]; other site 198628001214 esterase YqiA; Provisional; Region: PRK11071 198628001215 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 198628001216 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 198628001217 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 198628001218 ATP binding site [chemical binding]; other site 198628001219 Mg2+ binding site [ion binding]; other site 198628001220 G-X-G motif; other site 198628001221 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 198628001222 anchoring element; other site 198628001223 dimer interface [polypeptide binding]; other site 198628001224 ATP binding site [chemical binding]; other site 198628001225 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 198628001226 active site 198628001227 metal binding site [ion binding]; metal-binding site 198628001228 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 198628001229 Transcriptional regulator [Transcription]; Region: LysR; COG0583 198628001230 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 198628001231 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 198628001232 dimerization interface [polypeptide binding]; other site 198628001233 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 198628001234 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 198628001235 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 198628001236 CAP-like domain; other site 198628001237 active site 198628001238 primary dimer interface [polypeptide binding]; other site 198628001239 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 198628001240 1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional; Region: PRK15018 198628001241 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 198628001242 putative acyl-acceptor binding pocket; other site 198628001243 FtsI repressor; Provisional; Region: PRK10883 198628001244 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 198628001245 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 198628001246 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 198628001247 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 198628001248 active site 198628001249 catalytic tetrad [active] 198628001250 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 198628001251 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 198628001252 dimer interface [polypeptide binding]; other site 198628001253 active site 198628001254 metal binding site [ion binding]; metal-binding site 198628001255 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 198628001256 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 198628001257 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 198628001258 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 198628001259 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 198628001260 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 198628001261 cystathionine beta-lyase; Provisional; Region: PRK08114 198628001262 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 198628001263 homodimer interface [polypeptide binding]; other site 198628001264 substrate-cofactor binding pocket; other site 198628001265 pyridoxal 5'-phosphate binding site [chemical binding]; other site 198628001266 catalytic residue [active] 198628001267 biopolymer transport protein ExbB; Provisional; Region: PRK10414 198628001268 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 198628001269 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 198628001270 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 198628001271 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 198628001272 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 198628001273 D-fructose-responsive transcription factor; Region: fruct_sucro_rep; TIGR02417 198628001274 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 198628001275 DNA binding site [nucleotide binding] 198628001276 domain linker motif; other site 198628001277 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 198628001278 dimerization interface [polypeptide binding]; other site 198628001279 ligand binding site [chemical binding]; other site 198628001280 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 198628001281 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 198628001282 substrate binding [chemical binding]; other site 198628001283 active site 198628001284 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 198628001285 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 198628001286 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 198628001287 active site turn [active] 198628001288 phosphorylation site [posttranslational modification] 198628001289 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 198628001290 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 198628001291 trimer interface; other site 198628001292 sugar binding site [chemical binding]; other site 198628001293 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 198628001294 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 198628001295 putative substrate binding site [chemical binding]; other site 198628001296 putative ATP binding site [chemical binding]; other site 198628001297 CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cd09729 198628001298 hypothetical protein; Provisional; Region: PRK03467 198628001299 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 198628001300 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 198628001301 FeS/SAM binding site; other site 198628001302 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 198628001303 ATP cone domain; Region: ATP-cone; pfam03477 198628001304 Class III ribonucleotide reductase; Region: RNR_III; cd01675 198628001305 effector binding site; other site 198628001306 active site 198628001307 Zn binding site [ion binding]; other site 198628001308 glycine loop; other site 198628001309 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 198628001310 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 198628001311 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 198628001312 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 198628001313 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 198628001314 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198628001315 dimer interface [polypeptide binding]; other site 198628001316 conserved gate region; other site 198628001317 putative PBP binding loops; other site 198628001318 ABC-ATPase subunit interface; other site 198628001319 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 198628001320 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198628001321 dimer interface [polypeptide binding]; other site 198628001322 conserved gate region; other site 198628001323 ABC-ATPase subunit interface; other site 198628001324 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 198628001325 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 198628001326 Walker A/P-loop; other site 198628001327 ATP binding site [chemical binding]; other site 198628001328 Q-loop/lid; other site 198628001329 ABC transporter signature motif; other site 198628001330 Walker B; other site 198628001331 D-loop; other site 198628001332 H-loop/switch region; other site 198628001333 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 198628001334 Walker A/P-loop; other site 198628001335 ATP binding site [chemical binding]; other site 198628001336 Q-loop/lid; other site 198628001337 ABC transporter signature motif; other site 198628001338 Walker B; other site 198628001339 D-loop; other site 198628001340 H-loop/switch region; other site 198628001341 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 198628001342 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 198628001343 indole acetimide hydrolase; Validated; Region: PRK07488 198628001344 Amidase; Region: Amidase; pfam01425 198628001345 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 198628001346 homotrimer interaction site [polypeptide binding]; other site 198628001347 putative active site [active] 198628001348 aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893 198628001349 Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948 198628001350 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 198628001351 Aspartate carbamoyltransferase, catalytic chain [Nucleotide transport and metabolism]; Region: PyrB; COG0540 198628001352 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 198628001353 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 198628001354 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 198628001355 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 198628001356 beta-galactosidase; Region: BGL; TIGR03356 198628001357 ornithine carbamoyltransferase subunit I; Provisional; Region: PRK03515 198628001358 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 198628001359 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 198628001360 RNase E inhibitor protein; Provisional; Region: PRK11191 198628001361 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 198628001362 Coenzyme A binding pocket [chemical binding]; other site 198628001363 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 198628001364 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 198628001365 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 198628001366 sequence-specific DNA binding site [nucleotide binding]; other site 198628001367 salt bridge; other site 198628001368 Cupin domain; Region: Cupin_2; cl17218 198628001369 Cupin domain; Region: Cupin_2; pfam07883 198628001370 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 198628001371 hypothetical protein; Provisional; Region: PRK06489 198628001372 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 198628001373 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 198628001374 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 198628001375 dimerization interface [polypeptide binding]; other site 198628001376 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 198628001377 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 198628001378 dimer interface [polypeptide binding]; other site 198628001379 putative CheW interface [polypeptide binding]; other site 198628001380 putative transposase OrfB; Reviewed; Region: PHA02517 198628001381 HTH-like domain; Region: HTH_21; pfam13276 198628001382 Integrase core domain; Region: rve; pfam00665 198628001383 Integrase core domain; Region: rve_2; pfam13333 198628001384 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198628001385 Helix-turn-helix domain; Region: HTH_28; pfam13518 198628001386 Helix-turn-helix domain; Region: HTH_28; pfam13518 198628001387 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 198628001388 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 198628001389 HIGH motif; other site 198628001390 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 198628001391 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 198628001392 active site 198628001393 KMSKS motif; other site 198628001394 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 198628001395 tRNA binding surface [nucleotide binding]; other site 198628001396 anticodon binding site; other site 198628001397 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 198628001398 DNA polymerase III subunit chi; Validated; Region: PRK05728 198628001399 multifunctional aminopeptidase A; Provisional; Region: PRK00913 198628001400 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 198628001401 interface (dimer of trimers) [polypeptide binding]; other site 198628001402 Substrate-binding/catalytic site; other site 198628001403 Zn-binding sites [ion binding]; other site 198628001404 lipopolysaccharide ABC transporter permease LptF; Provisional; Region: PRK15120 198628001405 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 198628001406 lipopolysaccharide ABC transporter permease; Provisional; Region: PRK15071 198628001407 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 198628001408 integrase; Provisional; Region: PRK09692 198628001409 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 198628001410 active site 198628001411 Int/Topo IB signature motif; other site 198628001412 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 198628001413 ATP binding site [chemical binding]; other site 198628001414 putative Mg++ binding site [ion binding]; other site 198628001415 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 198628001416 nucleotide binding region [chemical binding]; other site 198628001417 ATP-binding site [chemical binding]; other site 198628001418 Domain of unknown function (DUF1837); Region: DUF1837; pfam08878 198628001419 Phage integrase, N-terminal; Region: Integrase_l_N; pfam12834 198628001420 Integrase; Region: Integrase_1; pfam12835 198628001421 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 198628001422 Ash protein family; Region: Phage_ASH; pfam10554 198628001423 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4643 198628001424 Zinc-binding domain of primase-helicase; Region: Prim_Zn_Ribbon; smart00778 198628001425 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 198628001426 AAA domain; Region: AAA_25; pfam13481 198628001427 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 198628001428 ATP binding site [chemical binding]; other site 198628001429 Walker B motif; other site 198628001430 Winged helix-turn-helix DNA-binding; Region: HTH_35; pfam13693 198628001431 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 198628001432 sequence-specific DNA binding site [nucleotide binding]; other site 198628001433 salt bridge; other site 198628001434 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 198628001435 Coenzyme A binding pocket [chemical binding]; other site 198628001436 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453 198628001437 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 198628001438 S-adenosylmethionine binding site [chemical binding]; other site 198628001439 hypothetical protein; Provisional; Region: PRK13687 198628001440 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 198628001441 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 198628001442 putative DNA binding site [nucleotide binding]; other site 198628001443 putative Zn2+ binding site [ion binding]; other site 198628001444 AsnC family; Region: AsnC_trans_reg; pfam01037 198628001445 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 198628001446 Protein of unknown function (DUF2000); Region: DUF2000; cl02074 198628001447 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 198628001448 Prephenate dehydratase; Region: PDT; pfam00800 198628001449 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 198628001450 Lysine efflux permease [General function prediction only]; Region: COG1279 198628001451 HNH endonuclease; Region: HNH_2; pfam13391 198628001452 Major Facilitator Superfamily; Region: MFS_1; pfam07690 198628001453 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198628001454 putative substrate translocation pore; other site 198628001455 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198628001456 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 198628001457 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 198628001458 DNA-binding site [nucleotide binding]; DNA binding site 198628001459 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 198628001460 pyridoxal 5'-phosphate binding site [chemical binding]; other site 198628001461 homodimer interface [polypeptide binding]; other site 198628001462 catalytic residue [active] 198628001463 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 198628001464 Coenzyme A binding pocket [chemical binding]; other site 198628001465 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 198628001466 Uncharacterized conserved protein [Function unknown]; Region: COG2128 198628001467 Domain of unknown function (DUF4276); Region: DUF4276; pfam14103 198628001468 Predicted ATPase [General function prediction only]; Region: COG4637 198628001469 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 198628001470 Walker A/P-loop; other site 198628001471 ATP binding site [chemical binding]; other site 198628001472 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 198628001473 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 198628001474 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 198628001475 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 198628001476 TPP-binding site [chemical binding]; other site 198628001477 dimer interface [polypeptide binding]; other site 198628001478 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 198628001479 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 198628001480 PYR/PP interface [polypeptide binding]; other site 198628001481 dimer interface [polypeptide binding]; other site 198628001482 TPP binding site [chemical binding]; other site 198628001483 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 198628001484 short chain dehydrogenase; Provisional; Region: PRK06841 198628001485 classical (c) SDRs; Region: SDR_c; cd05233 198628001486 NAD(P) binding site [chemical binding]; other site 198628001487 active site 198628001488 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 198628001489 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 198628001490 Predicted periplasmic lipoprotein (DUF2291); Region: DUF2291; cl02395 198628001491 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 198628001492 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 198628001493 Walker A/P-loop; other site 198628001494 ATP binding site [chemical binding]; other site 198628001495 Q-loop/lid; other site 198628001496 ABC transporter signature motif; other site 198628001497 Walker B; other site 198628001498 D-loop; other site 198628001499 H-loop/switch region; other site 198628001500 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 198628001501 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 198628001502 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 198628001503 TM-ABC transporter signature motif; other site 198628001504 Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554 198628001505 bacterial glycerol kinase 2-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_GK2_bacteria; cd07791 198628001506 N- and C-terminal domain interface [polypeptide binding]; other site 198628001507 active site 198628001508 MgATP binding site [chemical binding]; other site 198628001509 catalytic site [active] 198628001510 metal binding site [ion binding]; metal-binding site 198628001511 putative homotetramer interface [polypeptide binding]; other site 198628001512 putative homodimer interface [polypeptide binding]; other site 198628001513 glycerol binding site [chemical binding]; other site 198628001514 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 198628001515 meso-2,3-butanediol dehydrogenase-like, classical (c) SDRs; Region: meso-BDH-like_SDR_c; cd05366 198628001516 NAD binding site [chemical binding]; other site 198628001517 homotetramer interface [polypeptide binding]; other site 198628001518 homodimer interface [polypeptide binding]; other site 198628001519 active site 198628001520 substrate binding site [chemical binding]; other site 198628001521 Bacillus thuringiensis toxin; Region: Bac_thur_toxin; pfam01338 198628001522 Bacillus thuringiensis toxin; Region: Bac_thur_toxin; pfam01338 198628001523 Bacillus thuringiensis toxin; Region: Bac_thur_toxin; pfam01338 198628001524 Bacillus thuringiensis toxin; Region: Bac_thur_toxin; pfam01338 198628001525 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 198628001526 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_10; cd08515 198628001527 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 198628001528 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198628001529 dimer interface [polypeptide binding]; other site 198628001530 conserved gate region; other site 198628001531 putative PBP binding loops; other site 198628001532 ABC-ATPase subunit interface; other site 198628001533 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 198628001534 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198628001535 dimer interface [polypeptide binding]; other site 198628001536 conserved gate region; other site 198628001537 putative PBP binding loops; other site 198628001538 ABC-ATPase subunit interface; other site 198628001539 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 198628001540 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 198628001541 Walker A/P-loop; other site 198628001542 ATP binding site [chemical binding]; other site 198628001543 Q-loop/lid; other site 198628001544 ABC transporter signature motif; other site 198628001545 Walker B; other site 198628001546 D-loop; other site 198628001547 H-loop/switch region; other site 198628001548 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 198628001549 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 198628001550 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 198628001551 Walker A/P-loop; other site 198628001552 ATP binding site [chemical binding]; other site 198628001553 Q-loop/lid; other site 198628001554 ABC transporter signature motif; other site 198628001555 Walker B; other site 198628001556 D-loop; other site 198628001557 H-loop/switch region; other site 198628001558 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 198628001559 hypothetical protein; Provisional; Region: PRK07079 198628001560 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_2; cd05679 198628001561 metal binding site [ion binding]; metal-binding site 198628001562 putative dimer interface [polypeptide binding]; other site 198628001563 Transcriptional regulator [Transcription]; Region: LysR; COG0583 198628001564 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 198628001565 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 198628001566 dimerization interface [polypeptide binding]; other site 198628001567 1-aminocyclopropane-1-carboxylate deaminase [Amino acid transport and metabolism]; Region: Acd; COG2515 198628001568 Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449 198628001569 pyridoxal 5'-phosphate binding site [chemical binding]; other site 198628001570 catalytic residue [active] 198628001571 Predicted ATPase [General function prediction only]; Region: COG4637 198628001572 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 198628001573 Walker A/P-loop; other site 198628001574 ATP binding site [chemical binding]; other site 198628001575 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 198628001576 ABC transporter signature motif; other site 198628001577 Walker B; other site 198628001578 D-loop; other site 198628001579 H-loop/switch region; other site 198628001580 Domain of unknown function (DUF4276); Region: DUF4276; pfam14103 198628001581 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 198628001582 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 198628001583 putative DNA binding site [nucleotide binding]; other site 198628001584 putative Zn2+ binding site [ion binding]; other site 198628001585 AsnC family; Region: AsnC_trans_reg; pfam01037 198628001586 chorismate mutase; Provisional; Region: PRK08055 198628001587 Major Facilitator Superfamily; Region: MFS_1; pfam07690 198628001588 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 198628001589 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 198628001590 Zn2+ binding site [ion binding]; other site 198628001591 Mg2+ binding site [ion binding]; other site 198628001592 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 198628001593 Transcriptional regulator [Transcription]; Region: IclR; COG1414 198628001594 Bacterial transcriptional regulator; Region: IclR; pfam01614 198628001595 CHASE3 domain; Region: CHASE3; cl05000 198628001596 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 198628001597 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 198628001598 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 198628001599 dimer interface [polypeptide binding]; other site 198628001600 putative CheW interface [polypeptide binding]; other site 198628001601 L-rhamnose 1-epimerase; Region: YiiL_rotase; TIGR02625 198628001602 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 198628001603 intersubunit interface [polypeptide binding]; other site 198628001604 active site 198628001605 Zn2+ binding site [ion binding]; other site 198628001606 L-rhamnose isomerase; Provisional; Region: PRK01076 198628001607 Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900 198628001608 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 198628001609 N- and C-terminal domain interface [polypeptide binding]; other site 198628001610 active site 198628001611 putative catalytic site [active] 198628001612 metal binding site [ion binding]; metal-binding site 198628001613 ATP binding site [chemical binding]; other site 198628001614 rhamnulokinase; Provisional; Region: rhaB; PRK10640 198628001615 carbohydrate binding site [chemical binding]; other site 198628001616 transcriptional activator RhaS; Provisional; Region: PRK13503 198628001617 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 198628001618 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 198628001619 transcriptional activator RhaR; Provisional; Region: PRK13501 198628001620 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 198628001621 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 198628001622 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 198628001623 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 198628001624 Walker A/P-loop; other site 198628001625 ATP binding site [chemical binding]; other site 198628001626 Q-loop/lid; other site 198628001627 ABC transporter signature motif; other site 198628001628 Walker B; other site 198628001629 D-loop; other site 198628001630 H-loop/switch region; other site 198628001631 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 198628001632 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 198628001633 Walker A/P-loop; other site 198628001634 ATP binding site [chemical binding]; other site 198628001635 Q-loop/lid; other site 198628001636 ABC transporter signature motif; other site 198628001637 Walker B; other site 198628001638 D-loop; other site 198628001639 H-loop/switch region; other site 198628001640 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 198628001641 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 198628001642 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198628001643 dimer interface [polypeptide binding]; other site 198628001644 conserved gate region; other site 198628001645 putative PBP binding loops; other site 198628001646 ABC-ATPase subunit interface; other site 198628001647 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 198628001648 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 198628001649 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 198628001650 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_15; cd08492 198628001651 Protein of unknown function (DUF1440); Region: DUF1440; pfam07274 198628001652 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 198628001653 Transposase; Region: DEDD_Tnp_IS110; pfam01548 198628001654 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 198628001655 oxidoreductase; Provisional; Region: PRK08013 198628001656 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 198628001657 2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK05732 198628001658 2-polyprenyl-6-methoxyphenol 4-hydroxylase; Region: UbiH; TIGR01984 198628001659 proline aminopeptidase P II; Provisional; Region: PRK10879 198628001660 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 198628001661 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 198628001662 active site 198628001663 hypothetical protein; Reviewed; Region: PRK01736 198628001664 Z-ring-associated protein; Provisional; Region: PRK10972 198628001665 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360 198628001666 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 198628001667 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 198628001668 non-specific DNA binding site [nucleotide binding]; other site 198628001669 salt bridge; other site 198628001670 bifunctional DNA-binding transcriptional repressor/ NMN adenylyltransferase; Provisional; Region: PRK08099 198628001671 sequence-specific DNA binding site [nucleotide binding]; other site 198628001672 Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional NadR-like proteins; Region: NMNAT_NadR; cd02167 198628001673 active site 198628001674 (T/H)XGH motif; other site 198628001675 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 198628001676 DNA repair protein RadA; Provisional; Region: PRK11823 198628001677 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 198628001678 Walker A motif/ATP binding site; other site 198628001679 ATP binding site [chemical binding]; other site 198628001680 Walker B motif; other site 198628001681 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 198628001682 phosphoserine phosphatase; Provisional; Region: serB; PRK11133 198628001683 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 198628001684 motif I; other site 198628001685 motif II; other site 198628001686 hypothetical protein; Provisional; Region: PRK11246 198628001687 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 198628001688 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 198628001689 S-adenosylmethionine binding site [chemical binding]; other site 198628001690 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 198628001691 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 198628001692 G1 box; other site 198628001693 putative GEF interaction site [polypeptide binding]; other site 198628001694 GTP/Mg2+ binding site [chemical binding]; other site 198628001695 Switch I region; other site 198628001696 G2 box; other site 198628001697 G3 box; other site 198628001698 Switch II region; other site 198628001699 G4 box; other site 198628001700 G5 box; other site 198628001701 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 198628001702 periplasmic protein; Provisional; Region: PRK10568 198628001703 BON domain; Region: BON; pfam04972 198628001704 BON domain; Region: BON; pfam04972 198628001705 CsbD-like; Region: CsbD; cl17424 198628001706 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 198628001707 active site 198628001708 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 198628001709 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 198628001710 Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967 198628001711 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 198628001712 NAD(P) binding site [chemical binding]; other site 198628001713 active site 198628001714 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 198628001715 dimer interface [polypeptide binding]; other site 198628001716 ligand binding site [chemical binding]; other site 198628001717 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 198628001718 dimerization interface [polypeptide binding]; other site 198628001719 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 198628001720 dimer interface [polypeptide binding]; other site 198628001721 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 198628001722 putative CheW interface [polypeptide binding]; other site 198628001723 Flagellar protein FlhE; Region: FlhE; pfam06366 198628001724 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 198628001725 HD domain; Region: HD_4; pfam13328 198628001726 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 198628001727 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 198628001728 metal binding site [ion binding]; metal-binding site 198628001729 putative dimer interface [polypeptide binding]; other site 198628001730 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 198628001731 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 198628001732 Walker A/P-loop; other site 198628001733 ATP binding site [chemical binding]; other site 198628001734 Q-loop/lid; other site 198628001735 ABC transporter signature motif; other site 198628001736 Walker B; other site 198628001737 D-loop; other site 198628001738 H-loop/switch region; other site 198628001739 Metal binding protein TroA_a. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148 198628001740 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 198628001741 putative ligand binding residues [chemical binding]; other site 198628001742 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 198628001743 ABC-ATPase subunit interface; other site 198628001744 dimer interface [polypeptide binding]; other site 198628001745 putative PBP binding regions; other site 198628001746 alkyl hydroperoxide reductase subunit C; Provisional; Region: PRK10382 198628001747 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 198628001748 dimer interface [polypeptide binding]; other site 198628001749 decamer (pentamer of dimers) interface [polypeptide binding]; other site 198628001750 catalytic triad [active] 198628001751 peroxidatic and resolving cysteines [active] 198628001752 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 198628001753 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 198628001754 catalytic residue [active] 198628001755 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 198628001756 catalytic residues [active] 198628001757 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 198628001758 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 198628001759 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5255 198628001760 Domain of unknown function (DUF1868); Region: 2H-phosphodiest; pfam08975 198628001761 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 198628001762 trimer interface [polypeptide binding]; other site 198628001763 active site 198628001764 substrate binding site [chemical binding]; other site 198628001765 CoA binding site [chemical binding]; other site 198628001766 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 198628001767 active site 198628001768 homotetramer interface [polypeptide binding]; other site 198628001769 OHCU decarboxylase; Region: UraD_2; TIGR03180 198628001770 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 198628001771 Heavy-metal-associated domain; Region: HMA; pfam00403 198628001772 metal-binding site [ion binding] 198628001773 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 198628001774 Soluble P-type ATPase [General function prediction only]; Region: COG4087 198628001775 Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047 198628001776 Helix-Turn-Helix DNA binding domain of the CadR and PbrR transcription regulators; Region: HTH_CadR-PbrR; cd04784 198628001777 DNA binding residues [nucleotide binding] 198628001778 dimer interface [polypeptide binding]; other site 198628001779 putative metal binding site [ion binding]; other site 198628001780 Transcriptional regulators [Transcription]; Region: PurR; COG1609 198628001781 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 198628001782 DNA binding site [nucleotide binding] 198628001783 domain linker motif; other site 198628001784 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 198628001785 putative dimerization interface [polypeptide binding]; other site 198628001786 putative ligand binding site [chemical binding]; other site 198628001787 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 198628001788 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 198628001789 active site pocket [active] 198628001790 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 198628001791 Bacterial sugar transferase; Region: Bac_transf; pfam02397 198628001792 Uncharacterized protein conserved in bacteria (DUF2320); Region: DUF2320; pfam10082 198628001793 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 198628001794 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 198628001795 SLBB domain; Region: SLBB; pfam10531 198628001796 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 198628001797 Chain length determinant protein; Region: Wzz; pfam02706 198628001798 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 198628001799 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 198628001800 Polysaccharide biosynthesis protein; Region: Polysacc_synt_3; pfam13440 198628001801 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 198628001802 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 198628001803 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 198628001804 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 198628001805 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 198628001806 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495 198628001807 putative acyl transferase; Provisional; Region: PRK10191 198628001808 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 198628001809 trimer interface [polypeptide binding]; other site 198628001810 active site 198628001811 substrate binding site [chemical binding]; other site 198628001812 CoA binding site [chemical binding]; other site 198628001813 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453 198628001815 sporadically distributed protein, TIGR04141 family; Region: TIGR04141 198628001816 Domain of unknown function (DUF4102); Region: DUF4102; pfam13356 198628001817 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453 198628001818 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 198628001819 Coenzyme A binding pocket [chemical binding]; other site 198628001820 RT_Bac_retron_I: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_I; cd01646 198628001821 putative active site [active] 198628001822 putative NTP binding site [chemical binding]; other site 198628001823 putative nucleic acid binding site [nucleotide binding]; other site 198628001824 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 198628001825 RT_Bac_retron_I: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_I; cd01646 198628001826 putative active site [active] 198628001827 putative NTP binding site [chemical binding]; other site 198628001828 putative nucleic acid binding site [nucleotide binding]; other site 198628001829 plasmid maintenance protein CcdB; Provisional; Region: PRK13708 198628001830 plasmid maintenance protein CcdA; Provisional; Region: PRK13710 198628001831 integrase; Provisional; Region: PRK09692 198628001832 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 198628001833 active site 198628001834 Int/Topo IB signature motif; other site 198628001835 putative transcriptional regulator; Provisional; Region: PRK11640 198628001836 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 198628001837 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 198628001838 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 198628001839 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 198628001840 DsbD alpha interface [polypeptide binding]; other site 198628001841 catalytic residues [active] 198628001842 divalent-cation tolerance protein CutA; Provisional; Region: PRK10645 198628001843 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 198628001844 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 198628001845 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 198628001846 Aspartase; Region: Aspartase; cd01357 198628001847 active sites [active] 198628001848 tetramer interface [polypeptide binding]; other site 198628001849 Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030 198628001850 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 198628001851 oligomerisation interface [polypeptide binding]; other site 198628001852 mobile loop; other site 198628001853 roof hairpin; other site 198628001854 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 198628001855 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 198628001856 ring oligomerisation interface [polypeptide binding]; other site 198628001857 ATP/Mg binding site [chemical binding]; other site 198628001858 stacking interactions; other site 198628001859 hinge regions; other site 198628001860 chorismate pyruvate lyase; Provisional; Region: ubiC; PRK11655 198628001861 4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848 198628001862 UbiA prenyltransferase family; Region: UbiA; pfam01040 198628001863 glycerol-3-phosphate O-acyltransferase; Region: plsB; TIGR03703 198628001864 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 198628001865 putative acyl-acceptor binding pocket; other site 198628001866 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 198628001867 LexA repressor; Validated; Region: PRK00215 198628001868 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 198628001869 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 198628001870 Catalytic site [active] 198628001871 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 198628001872 metal binding site 2 [ion binding]; metal-binding site 198628001873 putative DNA binding helix; other site 198628001874 metal binding site 1 [ion binding]; metal-binding site 198628001875 dimer interface [polypeptide binding]; other site 198628001876 structural Zn2+ binding site [ion binding]; other site 198628001877 Pirin-related protein [General function prediction only]; Region: COG1741 198628001878 Pirin; Region: Pirin; pfam02678 198628001879 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 198628001880 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 198628001881 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 198628001882 dimerization interface [polypeptide binding]; other site 198628001883 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 198628001884 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 198628001885 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 198628001886 putative dimer interface [polypeptide binding]; other site 198628001887 N-terminal domain interface [polypeptide binding]; other site 198628001888 putative substrate binding pocket (H-site) [chemical binding]; other site 198628001889 Predicted membrane protein [Function unknown]; Region: COG2259 198628001890 YqjK-like protein; Region: YqjK; pfam13997 198628001891 Predicted membrane protein [Function unknown]; Region: COG5393 198628001892 Uncharacterized conserved protein [Function unknown]; Region: ElaB; COG4575 198628001893 EnvZ/OmpR regulon moderator; Provisional; Region: PRK10629 198628001894 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 198628001895 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 198628001896 DNA-binding transcriptional repressor ExuR; Provisional; Region: PRK11523 198628001897 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 198628001898 DNA-binding site [nucleotide binding]; DNA binding site 198628001899 FCD domain; Region: FCD; pfam07729 198628001900 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198628001901 D-galactonate transporter; Region: 2A0114; TIGR00893 198628001902 putative substrate translocation pore; other site 198628001903 Glucuronate isomerase; Region: UxaC; pfam02614 198628001904 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 198628001905 altronate oxidoreductase; Provisional; Region: PRK03643 198628001906 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 198628001907 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 198628001908 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 198628001909 galactarate dehydratase; Region: galactar-dH20; TIGR03248 198628001910 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 198628001911 Bacterial inner membrane protein; Region: Imp-YgjV; pfam10688 198628001912 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 198628001913 SAM-dependent 23S ribosomal RNA mG1835 methyltransferase; Provisional; Region: PRK15001 198628001914 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 198628001915 S-adenosylmethionine binding site [chemical binding]; other site 198628001916 Pectate lyase; Region: Pec_lyase_C; cl01593 198628001917 DNA-binding transcriptional activator UhpA; Provisional; Region: PRK10360 198628001918 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 198628001919 active site 198628001920 phosphorylation site [posttranslational modification] 198628001921 intermolecular recognition site; other site 198628001922 dimerization interface [polypeptide binding]; other site 198628001923 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 198628001924 DNA binding residues [nucleotide binding] 198628001925 dimerization interface [polypeptide binding]; other site 198628001926 sensory histidine kinase UhpB; Provisional; Region: PRK11644 198628001927 MASE1; Region: MASE1; cl17823 198628001928 Histidine kinase; Region: HisKA_3; pfam07730 198628001929 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 198628001930 regulatory protein UhpC; Provisional; Region: PRK11663 198628001931 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198628001932 putative substrate translocation pore; other site 198628001933 sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556 198628001934 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198628001935 putative substrate translocation pore; other site 198628001936 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 198628001937 dimer interface [polypeptide binding]; other site 198628001938 thiamine biosynthesis lipoprotein ApbE; Provisional; Region: PRK10461 198628001939 ApbE family; Region: ApbE; pfam02424 198628001940 2-isopropylmalate synthase; Validated; Region: PRK03739 198628001941 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 198628001942 active site 198628001943 catalytic residues [active] 198628001944 metal binding site [ion binding]; metal-binding site 198628001945 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 198628001946 Cupin domain; Region: Cupin_2; cl17218 198628001947 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 198628001948 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 198628001950 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 198628001951 ApbE family; Region: ApbE; pfam02424 198628001952 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 198628001953 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 198628001954 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 198628001955 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 198628001956 active site 198628001957 catalytic tetrad [active] 198628001958 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 198628001959 NAD(P) binding site [chemical binding]; other site 198628001960 active site 198628001961 short chain dehydrogenase; Provisional; Region: PRK06179 198628001962 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 198628001963 NADP binding site [chemical binding]; other site 198628001964 active site 198628001965 steroid binding site; other site 198628001966 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 198628001967 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 198628001968 putative NAD(P) binding site [chemical binding]; other site 198628001969 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 198628001970 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 198628001971 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 198628001972 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 198628001973 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 198628001974 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 198628001975 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 198628001976 DNA binding residues [nucleotide binding] 198628001977 DNA primase; Validated; Region: dnaG; PRK05667 198628001978 CHC2 zinc finger; Region: zf-CHC2; pfam01807 198628001979 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 198628001980 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 198628001981 active site 198628001982 metal binding site [ion binding]; metal-binding site 198628001983 interdomain interaction site; other site 198628001984 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 198628001985 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278 198628001986 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 198628001987 UGMP family protein; Validated; Region: PRK09604 198628001988 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 198628001989 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 198628001990 arginine repressor; Provisional; Region: PRK05066 198628001991 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 198628001992 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 198628001993 malate dehydrogenase; Provisional; Region: PRK05086 198628001994 Glyoxysomal and mitochondrial malate dehydrogenases; Region: MDH_glyoxysomal_mitochondrial; cd01337 198628001995 NAD binding site [chemical binding]; other site 198628001996 dimerization interface [polypeptide binding]; other site 198628001997 Substrate binding site [chemical binding]; other site 198628001998 Winged helix-turn-helix DNA-binding; Region: HTH_35; pfam13693 198628001999 Putative transcription regulator (DUF1323); Region: DUF1323; pfam07037 198628002000 Mu DNA-binding domain; Region: HTH_Tnp_Mu_1; pfam02316 198628002001 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 198628002002 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 198628002003 substrate binding pocket [chemical binding]; other site 198628002004 chain length determination region; other site 198628002005 substrate-Mg2+ binding site; other site 198628002006 catalytic residues [active] 198628002007 aspartate-rich region 1; other site 198628002008 active site lid residues [active] 198628002009 aspartate-rich region 2; other site 198628002010 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 198628002011 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 198628002012 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 198628002013 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 198628002014 EamA-like transporter family; Region: EamA; pfam00892 198628002015 GTPase CgtA; Reviewed; Region: obgE; PRK12298 198628002016 GTP1/OBG; Region: GTP1_OBG; pfam01018 198628002017 Obg GTPase; Region: Obg; cd01898 198628002018 G1 box; other site 198628002019 GTP/Mg2+ binding site [chemical binding]; other site 198628002020 Switch I region; other site 198628002021 G2 box; other site 198628002022 G3 box; other site 198628002023 Switch II region; other site 198628002024 G4 box; other site 198628002025 G5 box; other site 198628002026 D-alanyl-D-alanine carboxypeptidase/endopeptidase; Provisional; Region: PRK11113 198628002027 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 198628002028 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 198628002029 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 198628002030 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 198628002031 RNA-binding protein YhbY; Provisional; Region: PRK10343 198628002032 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 198628002033 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 198628002034 S-adenosylmethionine binding site [chemical binding]; other site 198628002035 ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733 198628002036 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 198628002037 Walker A motif; other site 198628002038 ATP binding site [chemical binding]; other site 198628002039 Walker B motif; other site 198628002040 arginine finger; other site 198628002041 Peptidase family M41; Region: Peptidase_M41; pfam01434 198628002042 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 198628002043 dihydropteroate synthase; Region: DHPS; TIGR01496 198628002044 substrate binding pocket [chemical binding]; other site 198628002045 dimer interface [polypeptide binding]; other site 198628002046 inhibitor binding site; inhibition site 198628002047 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 198628002048 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 198628002049 active site 198628002050 substrate binding site [chemical binding]; other site 198628002051 metal binding site [ion binding]; metal-binding site 198628002052 Preprotein translocase SecG subunit; Region: SecG; pfam03840 198628002053 ribosome maturation protein RimP; Reviewed; Region: PRK00092 198628002054 Sm and related proteins; Region: Sm_like; cl00259 198628002055 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 198628002056 putative oligomer interface [polypeptide binding]; other site 198628002057 putative RNA binding site [nucleotide binding]; other site 198628002058 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 198628002059 NusA N-terminal domain; Region: NusA_N; pfam08529 198628002060 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 198628002061 RNA binding site [nucleotide binding]; other site 198628002062 homodimer interface [polypeptide binding]; other site 198628002063 NusA-like KH domain; Region: KH_5; pfam13184 198628002064 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 198628002065 G-X-X-G motif; other site 198628002066 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 198628002067 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 198628002068 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 198628002069 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 198628002070 translation initiation factor IF-2; Region: IF-2; TIGR00487 198628002071 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 198628002072 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 198628002073 G1 box; other site 198628002074 putative GEF interaction site [polypeptide binding]; other site 198628002075 GTP/Mg2+ binding site [chemical binding]; other site 198628002076 Switch I region; other site 198628002077 G2 box; other site 198628002078 G3 box; other site 198628002079 Switch II region; other site 198628002080 G4 box; other site 198628002081 G5 box; other site 198628002082 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 198628002083 Translation-initiation factor 2; Region: IF-2; pfam11987 198628002084 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 198628002085 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 198628002086 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 198628002087 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 198628002088 RNA binding site [nucleotide binding]; other site 198628002089 active site 198628002090 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 198628002091 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 198628002092 16S/18S rRNA binding site [nucleotide binding]; other site 198628002093 S13e-L30e interaction site [polypeptide binding]; other site 198628002094 25S rRNA binding site [nucleotide binding]; other site 198628002095 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 198628002096 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 198628002097 RNase E interface [polypeptide binding]; other site 198628002098 trimer interface [polypeptide binding]; other site 198628002099 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 198628002100 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 198628002101 RNase E interface [polypeptide binding]; other site 198628002102 trimer interface [polypeptide binding]; other site 198628002103 active site 198628002104 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 198628002105 putative nucleic acid binding region [nucleotide binding]; other site 198628002106 G-X-X-G motif; other site 198628002107 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 198628002108 RNA binding site [nucleotide binding]; other site 198628002109 domain interface; other site 198628002110 lipoprotein NlpI; Provisional; Region: PRK11189 198628002111 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 198628002112 binding surface 198628002113 TPR motif; other site 198628002114 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 198628002115 DEAD-like helicases superfamily; Region: DEXDc; smart00487 198628002116 ATP binding site [chemical binding]; other site 198628002117 Mg++ binding site [ion binding]; other site 198628002118 motif III; other site 198628002119 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 198628002120 nucleotide binding region [chemical binding]; other site 198628002121 ATP-binding site [chemical binding]; other site 198628002122 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 198628002123 putative RNA binding site [nucleotide binding]; other site 198628002124 hypothetical protein; Provisional; Region: PRK10508 198628002125 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 198628002126 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 198628002127 putative protease; Provisional; Region: PRK15447 198628002128 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 198628002129 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 198628002130 Peptidase family U32; Region: Peptidase_U32; pfam01136 198628002131 Putative lipid carrier protein [Lipid metabolism]; Region: COG3154 198628002132 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 198628002133 Coenzyme A binding pocket [chemical binding]; other site 198628002134 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 198628002135 GIY-YIG motif/motif A; other site 198628002136 putative active site [active] 198628002137 putative metal binding site [ion binding]; other site 198628002138 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 198628002139 intersubunit interface [polypeptide binding]; other site 198628002140 active site 198628002141 catalytic residue [active] 198628002142 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 198628002143 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 198628002144 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 198628002145 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 198628002146 phosphopentomutase; Provisional; Region: PRK05362 198628002147 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 198628002148 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 198628002149 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 198628002150 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 198628002151 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 198628002152 active site 198628002153 metal binding site [ion binding]; metal-binding site 198628002154 Transcriptional regulator [Transcription]; Region: LysR; COG0583 198628002155 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 198628002156 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 198628002157 putative effector binding pocket; other site 198628002158 dimerization interface [polypeptide binding]; other site 198628002159 SnoaL-like domain; Region: SnoaL_2; pfam12680 198628002160 Uncharacterized conserved protein [Function unknown]; Region: COG1359 198628002161 ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491 198628002162 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 198628002163 Coenzyme A binding pocket [chemical binding]; other site 198628002164 DNA polymerase III subunit psi; Validated; Region: PRK06856 198628002165 16S ribosomal RNA m2G1207 methyltransferase; Provisional; Region: rsmC; PRK09489 198628002166 Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468 198628002167 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 198628002168 S-adenosylmethionine binding site [chemical binding]; other site 198628002169 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 198628002170 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 198628002171 active site 198628002172 catalytic tetrad [active] 198628002173 Transcriptional regulator [Transcription]; Region: LysR; COG0583 198628002174 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 198628002175 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 198628002176 putative effector binding pocket; other site 198628002177 putative dimerization interface [polypeptide binding]; other site 198628002178 Protein of unknown function (DUF1435); Region: DUF1435; pfam07256 198628002179 Transcriptional regulator [Transcription]; Region: LysR; COG0583 198628002180 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 198628002181 The C-terminal substrate binding domain of LysR-type transcrptional regulator BudR, which is responsible for activation of the expression of the butanediol operon genes; contains the type 2 periplasmic binding fold; Region: PBP2_BudR; cd08451 198628002182 putative dimerization interface [polypeptide binding]; other site 198628002183 putative substrate binding pocket [chemical binding]; other site 198628002184 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306 198628002185 acetolactate synthase; Reviewed; Region: PRK08617 198628002186 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 198628002187 PYR/PP interface [polypeptide binding]; other site 198628002188 dimer interface [polypeptide binding]; other site 198628002189 TPP binding site [chemical binding]; other site 198628002190 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 198628002191 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 198628002192 TPP-binding site [chemical binding]; other site 198628002193 dimer interface [polypeptide binding]; other site 198628002194 L-1,2-propanediol oxidoreductase; Provisional; Region: PRK10624 198628002195 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 198628002196 dimer interface [polypeptide binding]; other site 198628002197 active site 198628002198 metal binding site [ion binding]; metal-binding site 198628002199 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 198628002200 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 198628002201 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 198628002202 lipoyl attachment site [posttranslational modification]; other site 198628002203 glycine dehydrogenase; Provisional; Region: PRK05367 198628002204 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 198628002205 tetramer interface [polypeptide binding]; other site 198628002206 pyridoxal 5'-phosphate binding site [chemical binding]; other site 198628002207 catalytic residue [active] 198628002208 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 198628002209 tetramer interface [polypeptide binding]; other site 198628002210 pyridoxal 5'-phosphate binding site [chemical binding]; other site 198628002211 catalytic residue [active] 198628002212 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 198628002213 HD domain; Region: HD_3; pfam13023 198628002214 hemolysin; Provisional; Region: PRK15087 198628002215 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 198628002216 putative global regulator; Reviewed; Region: PRK09559 198628002217 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 198628002218 hypothetical protein; Provisional; Region: PRK10878 198628002219 Protein of unknown function (DUF1434); Region: DUF1434; pfam07254 198628002220 flavodoxin FldB; Provisional; Region: PRK12359 198628002221 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198628002222 metabolite-proton symporter; Region: 2A0106; TIGR00883 198628002223 putative substrate translocation pore; other site 198628002224 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 198628002225 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 198628002226 active site 198628002227 Int/Topo IB signature motif; other site 198628002228 protein disulfide isomerase II DsbC; Provisional; Region: PRK10877 198628002229 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 198628002230 dimerization domain [polypeptide binding]; other site 198628002231 dimer interface [polypeptide binding]; other site 198628002232 catalytic residues [active] 198628002233 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 198628002234 DHH family; Region: DHH; pfam01368 198628002235 DHHA1 domain; Region: DHHA1; pfam02272 198628002236 peptide chain release factor 2; Validated; Region: prfB; PRK00578 198628002237 This domain is found in peptide chain release factors; Region: PCRF; smart00937 198628002238 RF-1 domain; Region: RF-1; pfam00472 198628002239 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 198628002240 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 198628002241 dimer interface [polypeptide binding]; other site 198628002242 putative anticodon binding site; other site 198628002243 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 198628002244 motif 1; other site 198628002245 active site 198628002246 motif 2; other site 198628002247 motif 3; other site 198628002248 Ferritin-like; Region: Ferritin-like; pfam12902 198628002249 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 198628002250 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 198628002251 Phosphoesterase family; Region: Phosphoesterase; pfam04185 198628002252 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 198628002253 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 198628002254 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 198628002255 LysE type translocator; Region: LysE; cl00565 198628002256 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 198628002257 DNA-binding interface [nucleotide binding]; DNA binding site 198628002258 Winged helix-turn helix; Region: HTH_29; pfam13551 198628002259 putative transposase OrfB; Reviewed; Region: PHA02517 198628002260 HTH-like domain; Region: HTH_21; pfam13276 198628002261 Integrase core domain; Region: rve; pfam00665 198628002262 Integrase core domain; Region: rve_3; pfam13683 198628002263 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 198628002264 synthetase active site [active] 198628002265 NTP binding site [chemical binding]; other site 198628002266 metal binding site [ion binding]; metal-binding site 198628002267 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 198628002268 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 198628002269 HlyD family secretion protein; Region: HlyD_3; pfam13437 198628002270 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 198628002271 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 198628002272 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 198628002273 active site 198628002274 phosphorylation site [posttranslational modification] 198628002275 intermolecular recognition site; other site 198628002276 dimerization interface [polypeptide binding]; other site 198628002277 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 198628002278 DNA binding site [nucleotide binding] 198628002279 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 198628002280 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 198628002281 dimerization interface [polypeptide binding]; other site 198628002282 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 198628002283 dimer interface [polypeptide binding]; other site 198628002284 phosphorylation site [posttranslational modification] 198628002285 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 198628002286 ATP binding site [chemical binding]; other site 198628002287 G-X-G motif; other site 198628002288 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 198628002289 Predicted transcriptional regulators [Transcription]; Region: COG1733 198628002290 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 198628002291 dimerization interface [polypeptide binding]; other site 198628002292 putative DNA binding site [nucleotide binding]; other site 198628002293 putative Zn2+ binding site [ion binding]; other site 198628002294 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 198628002295 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 198628002296 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 198628002297 NAD(P) binding site [chemical binding]; other site 198628002298 homodimer interface [polypeptide binding]; other site 198628002299 substrate binding site [chemical binding]; other site 198628002300 active site 198628002301 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 198628002302 UDP-glucose 4 epimerase, subgroup 4, extended (e) SDRs; Region: UDP_G4E_4_SDR_e; cd05232 198628002303 putative NAD(P) binding site [chemical binding]; other site 198628002304 active site 198628002305 putative substrate binding site [chemical binding]; other site 198628002306 Bacterial sugar transferase; Region: Bac_transf; pfam02397 198628002307 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 198628002308 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 198628002309 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 198628002310 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 198628002311 Walker A/P-loop; other site 198628002312 ATP binding site [chemical binding]; other site 198628002313 Q-loop/lid; other site 198628002314 ABC transporter signature motif; other site 198628002315 Walker B; other site 198628002316 D-loop; other site 198628002317 H-loop/switch region; other site 198628002318 TOBE domain; Region: TOBE_2; pfam08402 198628002319 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 198628002320 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 198628002321 active site 198628002322 metal binding site [ion binding]; metal-binding site 198628002323 hexamer interface [polypeptide binding]; other site 198628002324 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 198628002325 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198628002326 dimer interface [polypeptide binding]; other site 198628002327 conserved gate region; other site 198628002328 putative PBP binding loops; other site 198628002329 ABC-ATPase subunit interface; other site 198628002330 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198628002331 dimer interface [polypeptide binding]; other site 198628002332 conserved gate region; other site 198628002333 putative PBP binding loops; other site 198628002334 ABC-ATPase subunit interface; other site 198628002335 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 198628002336 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 198628002337 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 198628002338 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 198628002339 putative acyl-acceptor binding pocket; other site 198628002340 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 198628002341 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 198628002342 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 198628002343 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 198628002344 Na binding site [ion binding]; other site 198628002345 Predicted membrane protein [Function unknown]; Region: COG3162 198628002346 acetyl-CoA synthetase; Provisional; Region: PRK00174 198628002347 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 198628002348 active site 198628002349 CoA binding site [chemical binding]; other site 198628002350 acyl-activating enzyme (AAE) consensus motif; other site 198628002351 AMP binding site [chemical binding]; other site 198628002352 acetate binding site [chemical binding]; other site 198628002353 Secretin and TonB N terminus short domain; Region: STN; smart00965 198628002354 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 198628002355 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 198628002356 N-terminal plug; other site 198628002357 ligand-binding site [chemical binding]; other site 198628002358 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 198628002359 Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 4. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_4; cd03329 198628002360 putative active site pocket [active] 198628002361 metal binding site [ion binding]; metal-binding site 198628002362 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 198628002363 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 198628002364 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 198628002365 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198628002366 dimer interface [polypeptide binding]; other site 198628002367 conserved gate region; other site 198628002368 putative PBP binding loops; other site 198628002369 ABC-ATPase subunit interface; other site 198628002370 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 198628002371 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 198628002372 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198628002373 ABC-ATPase subunit interface; other site 198628002374 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 198628002375 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 198628002376 Q-loop/lid; other site 198628002377 ABC transporter signature motif; other site 198628002378 Walker B; other site 198628002379 D-loop; other site 198628002380 H-loop/switch region; other site 198628002381 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 198628002382 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 198628002383 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 198628002384 Walker A/P-loop; other site 198628002385 ATP binding site [chemical binding]; other site 198628002386 Q-loop/lid; other site 198628002387 ABC transporter signature motif; other site 198628002388 Walker B; other site 198628002389 D-loop; other site 198628002390 H-loop/switch region; other site 198628002391 RNA polymerase sigma factor; Provisional; Region: PRK12528 198628002392 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 198628002393 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 198628002394 DNA binding residues [nucleotide binding] 198628002395 fec operon regulator FecR; Reviewed; Region: PRK09774 198628002396 FecR protein; Region: FecR; pfam04773 198628002397 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 198628002398 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 198628002399 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 198628002400 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 198628002401 non-specific DNA binding site [nucleotide binding]; other site 198628002402 salt bridge; other site 198628002403 sequence-specific DNA binding site [nucleotide binding]; other site 198628002404 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 198628002405 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 198628002406 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 198628002407 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 198628002408 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198628002409 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 198628002410 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 198628002411 HlyD family secretion protein; Region: HlyD_3; pfam13437 198628002412 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 198628002413 MarR family; Region: MarR_2; pfam12802 198628002414 L,D-transpeptidase; Provisional; Region: PRK10260 198628002415 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 198628002416 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 198628002417 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 198628002418 dimer interface [polypeptide binding]; other site 198628002419 PYR/PP interface [polypeptide binding]; other site 198628002420 TPP binding site [chemical binding]; other site 198628002421 substrate binding site [chemical binding]; other site 198628002422 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 198628002423 Domain of unknown function; Region: EKR; smart00890 198628002424 4Fe-4S binding domain; Region: Fer4_6; pfam12837 198628002425 4Fe-4S binding domain; Region: Fer4; pfam00037 198628002426 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 198628002427 TPP-binding site [chemical binding]; other site 198628002428 dimer interface [polypeptide binding]; other site 198628002429 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 198628002430 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 198628002431 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 198628002432 Uncharacterized protein family (UPF0257); Region: UPF0257; cl14672 198628002433 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 198628002434 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_2; cd09001 198628002435 active site 198628002436 putative symporter YagG; Provisional; Region: PRK09669 198628002437 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198628002438 putative substrate translocation pore; other site 198628002439 DinI-like family; Region: DinI; cl11630 198628002440 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 198628002441 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 198628002442 active site 198628002443 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2350 198628002444 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 198628002445 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 198628002446 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 198628002447 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 198628002448 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 198628002449 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 198628002450 Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992 198628002451 inhibitor-cofactor binding pocket; inhibition site 198628002452 pyridoxal 5'-phosphate binding site [chemical binding]; other site 198628002453 catalytic residue [active] 198628002454 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 198628002455 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH1; cd08185 198628002456 putative active site [active] 198628002457 metal binding site [ion binding]; metal-binding site 198628002458 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 198628002459 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 198628002460 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198628002461 putative substrate translocation pore; other site 198628002462 Transcriptional regulator [Transcription]; Region: LysR; COG0583 198628002463 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 198628002464 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA; cd08478 198628002465 putative effector binding pocket; other site 198628002466 dimerization interface [polypeptide binding]; other site 198628002467 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 198628002468 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 198628002469 active site 198628002470 catalytic tetrad [active] 198628002471 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 198628002472 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 198628002473 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 198628002474 putative active site [active] 198628002475 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 198628002476 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 198628002477 tetrameric interface [polypeptide binding]; other site 198628002478 NAD binding site [chemical binding]; other site 198628002479 catalytic residues [active] 198628002480 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 198628002481 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 198628002482 PYR/PP interface [polypeptide binding]; other site 198628002483 dimer interface [polypeptide binding]; other site 198628002484 TPP binding site [chemical binding]; other site 198628002485 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 198628002486 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 198628002487 TPP-binding site; other site 198628002488 DNA gyrase inhibitor; Provisional; Region: PRK10016 198628002489 PAS domain; Region: PAS_9; pfam13426 198628002490 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 198628002491 putative active site [active] 198628002492 heme pocket [chemical binding]; other site 198628002493 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 198628002494 PAS domain; Region: PAS_9; pfam13426 198628002495 putative active site [active] 198628002496 heme pocket [chemical binding]; other site 198628002497 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 198628002498 dimer interface [polypeptide binding]; other site 198628002499 putative CheW interface [polypeptide binding]; other site 198628002500 Predicted ATPase [General function prediction only]; Region: COG3910 198628002501 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 198628002502 Walker A/P-loop; other site 198628002503 ATP binding site [chemical binding]; other site 198628002504 Q-loop/lid; other site 198628002505 ABC transporter signature motif; other site 198628002506 Walker B; other site 198628002507 D-loop; other site 198628002508 H-loop/switch region; other site 198628002509 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 198628002510 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 198628002511 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 198628002512 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 198628002513 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 198628002514 ligand binding site [chemical binding]; other site 198628002515 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 198628002516 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 198628002517 Walker A/P-loop; other site 198628002518 ATP binding site [chemical binding]; other site 198628002519 Q-loop/lid; other site 198628002520 ABC transporter signature motif; other site 198628002521 Walker B; other site 198628002522 D-loop; other site 198628002523 H-loop/switch region; other site 198628002524 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 198628002525 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 198628002526 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 198628002527 TM-ABC transporter signature motif; other site 198628002528 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 198628002529 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 198628002530 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 198628002531 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 198628002532 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 198628002533 substrate binding site [chemical binding]; other site 198628002534 ATP binding site [chemical binding]; other site 198628002535 Uncharacterized protein conserved in bacteria (DUF2090); Region: DUF2090; pfam09863 198628002536 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3892 198628002537 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 198628002538 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 198628002539 DNA interaction; other site 198628002540 Metal-binding active site; metal-binding site 198628002541 Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718 198628002542 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 198628002543 Transposase; Region: DEDD_Tnp_IS110; pfam01548 198628002544 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 198628002545 Transglycosylase SLT domain; Region: SLT_2; pfam13406 198628002546 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 198628002547 N-acetyl-D-glucosamine binding site [chemical binding]; other site 198628002548 catalytic residue [active] 198628002549 Transcriptional regulator [Transcription]; Region: LysR; COG0583 198628002550 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 198628002551 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 198628002552 dimerization interface [polypeptide binding]; other site 198628002553 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198628002554 D-galactonate transporter; Region: 2A0114; TIGR00893 198628002555 putative substrate translocation pore; other site 198628002556 N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317 198628002557 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 198628002558 active site 198628002559 octamer interface [polypeptide binding]; other site 198628002560 Nucleoside recognition; Region: Gate; pfam07670 198628002561 histidine ABC transporter substrate-binding protein HisJ; Provisional; Region: PRK15437 198628002562 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 198628002563 substrate binding pocket [chemical binding]; other site 198628002564 membrane-bound complex binding site; other site 198628002565 hinge residues; other site 198628002566 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 198628002567 NADH(P)-binding; Region: NAD_binding_10; pfam13460 198628002568 NAD binding site [chemical binding]; other site 198628002569 substrate binding site [chemical binding]; other site 198628002570 putative active site [active] 198628002571 DoxX-like family; Region: DoxX_2; pfam13564 198628002572 Predicted transcriptional regulators [Transcription]; Region: COG1733 198628002573 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 198628002574 short chain dehydrogenase; Provisional; Region: PRK08263 198628002575 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 198628002576 NADP binding site [chemical binding]; other site 198628002577 active site 198628002578 steroid binding site; other site 198628002579 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06333 198628002580 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 198628002581 dimer interface [polypeptide binding]; other site 198628002582 active site 198628002583 short chain dehydrogenase; Provisional; Region: PRK06179 198628002584 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 198628002585 NADP binding site [chemical binding]; other site 198628002586 active site 198628002587 steroid binding site; other site 198628002588 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 198628002589 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 198628002590 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 198628002591 HlyD family secretion protein; Region: HlyD_3; pfam13437 198628002592 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 198628002593 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 198628002594 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 198628002595 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_3; cd13148 198628002596 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 198628002597 Transposase; Region: HTH_Tnp_1; pfam01527 198628002598 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 198628002599 HTH-like domain; Region: HTH_21; pfam13276 198628002600 Integrase core domain; Region: rve; pfam00665 198628002601 Integrase core domain; Region: rve_3; pfam13683 198628002602 Restriction endonuclease; Region: Mrr_cat; pfam04471 198628002603 NACHT domain; Region: NACHT; pfam05729 198628002604 integrase; Provisional; Region: PRK09692 198628002605 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 198628002606 active site 198628002607 Int/Topo IB signature motif; other site 198628002608 Domain of unknown function (DUF3596); Region: DUF3596; pfam12167 198628002609 phiCTX phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various phage and bacterial integrases, including those similar to phage integrases: Bordetella and...; Region: INT_phiCTX_C; cd01191 198628002610 Int/Topo IB signature motif; other site 198628002611 hypothetical protein; Reviewed; Region: PRK00024 198628002612 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 198628002613 MPN+ (JAMM) motif; other site 198628002614 Zinc-binding site [ion binding]; other site 198628002615 Uncharacterized conserved protein [Function unknown]; Region: COG5489 198628002616 Post-segregation antitoxin CcdA; Region: CcdA; pfam07362 198628002617 CcdB protein; Region: CcdB; pfam01845 198628002618 Uncharacterized conserved protein (DUF2285); Region: DUF2285; cl02246 198628002619 Replication initiator protein A; Region: RPA; pfam10134 198628002620 Signal peptidase, peptidase S26; Region: Peptidase_S26; pfam10502 198628002621 conjugal transfer pilin processing protease TraF; Provisional; Region: PRK13838 198628002622 Type IV secretory pathway, VirD2 components (relaxase) [Intracellular trafficking and secretion]; Region: VirD2; COG3843 198628002623 Protein of unknown function (DUF3363); Region: DUF3363; pfam11843 198628002624 DNA phosphorothioation-dependent restriction protein DptF; Region: dnd_assoc_3; TIGR03238 198628002625 DNA phosphorothioation-dependent restriction protein DptG; Region: dnd_assoc_1; TIGR03236 198628002627 Domain of unknown function (DUF1832); Region: DUF1832; pfam08870 198628002628 DNA sulfur modification protein DndD; Region: DNA_S_dndD; TIGR03185 198628002629 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 198628002630 Walker A/P-loop; other site 198628002631 ATP binding site [chemical binding]; other site 198628002632 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 198628002633 ABC transporter signature motif; other site 198628002634 Walker B; other site 198628002635 D-loop; other site 198628002636 H-loop/switch region; other site 198628002637 hypothetical protein; Provisional; Region: PRK06850 198628002638 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 198628002639 Active Sites [active] 198628002640 DNA-sulfur modification-associated; Region: DndB; pfam14072 198628002641 DGQHR domain; Region: DGQHR; TIGR03187 198628002642 Protein of unknown function (DUF3363); Region: DUF3363; pfam11843 198628002643 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 198628002644 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 198628002645 non-specific DNA binding site [nucleotide binding]; other site 198628002646 salt bridge; other site 198628002647 sequence-specific DNA binding site [nucleotide binding]; other site 198628002648 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 198628002649 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 198628002650 non-specific DNA binding site [nucleotide binding]; other site 198628002651 salt bridge; other site 198628002652 sequence-specific DNA binding site [nucleotide binding]; other site 198628002653 Winged helix-turn-helix DNA-binding; Region: HTH_35; pfam13693 198628002654 Transcriptional regulator [Transcription]; Region: LysR; COG0583 198628002655 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 198628002656 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 198628002657 dimerization interface [polypeptide binding]; other site 198628002658 substrate binding pocket [chemical binding]; other site 198628002659 conjugal transfer coupling protein TraG; Provisional; Region: PRK13876 198628002660 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 198628002661 Walker A motif; other site 198628002662 ATP binding site [chemical binding]; other site 198628002663 Walker B motif; other site 198628002664 P-type conjugative transfer ATPase TrbB; Region: TrbB_P; TIGR02782 198628002665 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 198628002666 ATP binding site [chemical binding]; other site 198628002667 Walker A motif; other site 198628002668 hexamer interface [polypeptide binding]; other site 198628002669 Walker B motif; other site 198628002670 Type IV secretory pathway, VirB2 components (pilins) [Intracellular trafficking and secretion]; Region: VirB2; COG3838 198628002671 Type IV secretory pathway, VirB3-like protein; Region: VirB3; cl01501 198628002672 conjugal transfer ATPase TrbE; Provisional; Region: PRK13873 198628002673 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 198628002674 Walker A motif; other site 198628002675 ATP binding site [chemical binding]; other site 198628002676 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 198628002677 Walker B; other site 198628002678 D-loop; other site 198628002679 H-loop/switch region; other site 198628002680 Conjugal transfer/entry exclusion protein [Intracellular trafficking and secretion]; Region: COG5314 198628002681 conjugal transfer protein TrbJ; Provisional; Region: PRK13874 198628002682 conjugal transfer protein TrbL; Provisional; Region: PRK13875 198628002683 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; cl01503 198628002684 conjugal transfer protein TrbF; Provisional; Region: PRK13872 198628002685 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 198628002686 VirB7 interaction site; other site 198628002687 Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743 198628002688 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 198628002689 RelB antitoxin; Region: RelB; cl01171 198628002690 Transcriptional regulator; Region: Rrf2; cl17282 198628002691 DNA binding protein, nucleoid-associated; Provisional; Region: PRK10328 198628002692 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 198628002693 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 198628002694 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 198628002695 non-specific DNA binding site [nucleotide binding]; other site 198628002696 salt bridge; other site 198628002697 sequence-specific DNA binding site [nucleotide binding]; other site 198628002698 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 198628002699 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 198628002700 non-specific DNA binding site [nucleotide binding]; other site 198628002701 salt bridge; other site 198628002702 sequence-specific DNA binding site [nucleotide binding]; other site 198628002703 Winged helix-turn-helix DNA-binding; Region: HTH_35; pfam13693 198628002704 Toxin SymE, type I toxin-antitoxin system; Region: SymE_toxin; cl07446 198628002705 PAAR motif; Region: PAAR_motif; pfam05488 198628002706 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 198628002707 RHS Repeat; Region: RHS_repeat; pfam05593 198628002708 RHS Repeat; Region: RHS_repeat; cl11982 198628002709 RHS Repeat; Region: RHS_repeat; cl11982 198628002710 RHS Repeat; Region: RHS_repeat; cl11982 198628002711 RHS Repeat; Region: RHS_repeat; cl11982 198628002712 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 198628002713 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; cl17626 198628002714 Domain of unknown function (DUF1795); Region: DUF1795; pfam08786 198628002715 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 198628002716 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 198628002717 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 198628002718 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 198628002719 integrase; Provisional; Region: int; PHA02601 198628002720 Phage HP1 integrase, C-terminal catalytic domain. Bacteriophage HP1 and related integrases are found in eubacteria, plasmids and temperate bacteriophages of the P2 family. They belong to the DNA breaking-rejoining enzyme superfamily, which includes...; Region: HP1_INT_C; cd00797 198628002721 dimer interface [polypeptide binding]; other site 198628002722 active site 198628002723 catalytic residues [active] 198628002724 Int/Topo IB signature motif; other site 198628002725 Uncharacterized conserved protein [Function unknown]; Region: COG4933 198628002726 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 198628002727 Bacteriophage CI repressor helix-turn-helix domain; Region: Phage_CI_repr; pfam07022 198628002728 Bacteriophage CI repressor helix-turn-helix domain; Region: Phage_CI_repr; pfam07022 198628002729 Predicted transcriptional regulator [Transcription]; Region: COG2932 198628002730 Bacteriophage CI repressor helix-turn-helix domain; Region: Phage_CI_repr; pfam07022 198628002731 Phage regulatory protein CII (CP76); Region: Phage_CP76; pfam06892 198628002732 Protein of unknown function (DUF2732); Region: DUF2732; pfam10809 198628002733 Bacteriophage replication gene A protein (GPA); Region: Phage_GPA; pfam05840 198628002734 Fic/DOC family; Region: Fic; pfam02661 198628002735 Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606 198628002736 Phage-related protein [Function unknown]; Region: COG4695; cl01923 198628002737 Phage portal protein; Region: Phage_portal; pfam04860 198628002738 terminase ATPase subunit; Provisional; Region: P; PHA02535 198628002739 Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056 198628002740 Mu-like prophage FluMu protein gp28 [General function prediction only]; Region: COG4373 198628002741 Phage capsid scaffolding protein (GPO) serine peptidase; Region: Phage_GPO; cl15838 198628002742 Phage major capsid protein, P2 family; Region: Phage_cap_P2; cl04947 198628002743 terminase endonuclease subunit; Provisional; Region: M; PHA02537 198628002744 Phage small terminase subunit; Region: Phage_term_smal; pfam05944 198628002745 Phage head completion protein (GPL); Region: Phage_GPL; pfam05926 198628002746 P2 phage tail completion protein R (GpR); Region: P2_Phage_GpR; pfam06891 198628002747 Protein of unknown function (DUF2586); Region: DUF2586; pfam10758 198628002748 Protein of unknown function (DUF2597); Region: DUF2597; pfam10772 198628002749 Phage holin family 2; Region: Phage_holin_2; pfam04550 198628002750 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 198628002751 Protein of unknown function (DUF2765); Region: DUF2765; pfam10963 198628002752 Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145 198628002753 Protein of unknown function (DUF2590); Region: DUF2590; pfam10761 198628002754 Baseplate J-like protein; Region: Baseplate_J; cl01294 198628002755 Baseplate J-like protein; Region: Baseplate_J; cl01294 198628002756 Phage tail-collar fibre protein; Region: DUF3751; pfam12571 198628002757 Phage Tail Collar Domain; Region: Collar; pfam07484 198628002758 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 198628002759 Uncharacterized protein family UPF0547; Region: UPF0547; pfam10571 198628002760 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 198628002761 SmpB-tmRNA interface; other site 198628002762 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 198628002763 putative coenzyme Q binding site [chemical binding]; other site 198628002764 hypothetical protein; Validated; Region: PRK01777 198628002765 outer membrane biogenesis protein BamE; Provisional; Region: PRK11548 198628002766 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 198628002767 recombination and repair protein; Provisional; Region: PRK10869 198628002768 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 198628002769 Walker A/P-loop; other site 198628002770 ATP binding site [chemical binding]; other site 198628002771 Q-loop/lid; other site 198628002772 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 198628002773 ABC transporter signature motif; other site 198628002774 Walker B; other site 198628002775 D-loop; other site 198628002776 H-loop/switch region; other site 198628002777 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03378 198628002778 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 198628002779 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 198628002780 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 198628002781 dimer interface [polypeptide binding]; other site 198628002782 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 198628002783 manganese transport protein MntH; Reviewed; Region: PRK00701 198628002784 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 198628002785 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 198628002786 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 198628002787 dimer interface [polypeptide binding]; other site 198628002788 ADP-ribose binding site [chemical binding]; other site 198628002789 active site 198628002790 nudix motif; other site 198628002791 metal binding site [ion binding]; metal-binding site 198628002792 transaldolase-like protein; Provisional; Region: PTZ00411 198628002793 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 198628002794 active site 198628002795 dimer interface [polypeptide binding]; other site 198628002796 catalytic residue [active] 198628002797 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 198628002798 Malic enzyme, N-terminal domain; Region: malic; pfam00390 198628002799 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 198628002800 putative NAD(P) binding site [chemical binding]; other site 198628002801 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 198628002802 hypothetical protein; Validated; Region: PRK00124 198628002803 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 198628002804 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 198628002805 putative acetyltransferase; Provisional; Region: PRK03624 198628002806 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 198628002807 Coenzyme A binding pocket [chemical binding]; other site 198628002808 transport protein TonB; Provisional; Region: PRK10819 198628002809 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 198628002810 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 198628002811 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 198628002812 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 198628002813 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 198628002814 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 198628002815 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 198628002816 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 198628002817 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 198628002818 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 198628002819 RpoE-regulated lipoprotein; Provisional; Region: PRK10718 198628002820 Protein of unknown function (DUF1131); Region: DUF1131; pfam06572 198628002821 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 198628002822 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 198628002823 active site 198628002824 TDP-binding site; other site 198628002825 acceptor substrate-binding pocket; other site 198628002826 Winged helix-turn-helix DNA-binding; Region: HTH_35; pfam13693 198628002827 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 198628002828 Coenzyme A binding pocket [chemical binding]; other site 198628002829 PAS fold; Region: PAS_4; pfam08448 198628002830 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 198628002831 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 198628002832 DNA binding residues [nucleotide binding] 198628002833 dimerization interface [polypeptide binding]; other site 198628002834 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 198628002835 Na binding site [ion binding]; other site 198628002836 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 198628002837 cysteine synthase B; Region: cysM; TIGR01138 198628002838 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 198628002839 dimer interface [polypeptide binding]; other site 198628002840 pyridoxal 5'-phosphate binding site [chemical binding]; other site 198628002841 catalytic residue [active] 198628002842 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 198628002843 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 198628002844 Protein of unknown function (DUF4225); Region: DUF4225; pfam13988 198628002845 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 198628002846 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 198628002847 Walker A/P-loop; other site 198628002848 ATP binding site [chemical binding]; other site 198628002849 Q-loop/lid; other site 198628002850 ABC transporter signature motif; other site 198628002851 Walker B; other site 198628002852 D-loop; other site 198628002853 H-loop/switch region; other site 198628002854 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 198628002855 FtsX-like permease family; Region: FtsX; pfam02687 198628002856 macrolide transporter subunit MacA; Provisional; Region: PRK11578 198628002857 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 198628002858 HlyD family secretion protein; Region: HlyD_3; pfam13437 198628002859 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 198628002860 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 198628002861 active site 198628002862 phosphorylation site [posttranslational modification] 198628002863 intermolecular recognition site; other site 198628002864 dimerization interface [polypeptide binding]; other site 198628002865 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 198628002866 DNA binding site [nucleotide binding] 198628002867 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 198628002868 dimerization interface [polypeptide binding]; other site 198628002869 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 198628002870 dimer interface [polypeptide binding]; other site 198628002871 phosphorylation site [posttranslational modification] 198628002872 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 198628002873 ATP binding site [chemical binding]; other site 198628002874 Mg2+ binding site [ion binding]; other site 198628002875 G-X-G motif; other site 198628002876 enoyl-CoA hydratase; Provisional; Region: PRK06563 198628002877 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 198628002878 substrate binding site [chemical binding]; other site 198628002879 oxyanion hole (OAH) forming residues; other site 198628002880 trimer interface [polypeptide binding]; other site 198628002881 Predicted transcriptional regulators [Transcription]; Region: COG1733 198628002882 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 198628002883 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 198628002884 HPr interaction site; other site 198628002885 glycerol kinase (GK) interaction site [polypeptide binding]; other site 198628002886 active site 198628002887 phosphorylation site [posttranslational modification] 198628002888 phosphoenolpyruvate-protein phosphotransferase; Provisional; Region: PRK11177 198628002889 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 198628002890 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 198628002891 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 198628002892 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 198628002893 dimerization domain swap beta strand [polypeptide binding]; other site 198628002894 regulatory protein interface [polypeptide binding]; other site 198628002895 active site 198628002896 regulatory phosphorylation site [posttranslational modification]; other site 198628002897 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 198628002898 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 198628002899 dimer interface [polypeptide binding]; other site 198628002900 pyridoxal 5'-phosphate binding site [chemical binding]; other site 198628002901 catalytic residue [active] 198628002902 putative sulfate transport protein CysZ; Validated; Region: PRK04949 198628002903 cell division protein ZipA; Provisional; Region: PRK03427 198628002904 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cl12038 198628002905 FtsZ protein binding site [polypeptide binding]; other site 198628002906 putative transporter; Provisional; Region: PRK11021 198628002907 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2960 198628002908 3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353 198628002909 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 198628002910 tellurite resistance protein TehB; Provisional; Region: PRK12335 198628002911 Uncharacterized protein/domain, possibly involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TehB; COG3615 198628002912 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 198628002913 S-adenosylmethionine binding site [chemical binding]; other site 198628002914 NADH:flavorubredoxin oxidoreductase; Provisional; Region: PRK04965 198628002915 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 198628002916 anaerobic nitric oxide reductase flavorubredoxin; Provisional; Region: PRK05452 198628002917 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 198628002918 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 198628002919 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 198628002920 iron binding site [ion binding]; other site 198628002921 anaerobic nitric oxide reductase transcription regulator; Provisional; Region: PRK05022 198628002922 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 198628002923 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 198628002924 Walker A motif; other site 198628002925 ATP binding site [chemical binding]; other site 198628002926 Walker B motif; other site 198628002927 arginine finger; other site 198628002928 fumarate hydratase; Provisional; Region: PRK15389 198628002929 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 198628002930 Fumarase C-terminus; Region: Fumerase_C; pfam05683 198628002931 Transcriptional regulator [Transcription]; Region: LysR; COG0583 198628002932 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 198628002933 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 198628002934 dimerization interface [polypeptide binding]; other site 198628002935 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 198628002936 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 198628002937 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 198628002938 endonuclease III; Region: ENDO3c; smart00478 198628002939 minor groove reading motif; other site 198628002940 helix-hairpin-helix signature motif; other site 198628002941 substrate binding pocket [chemical binding]; other site 198628002942 active site 198628002943 alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401 198628002944 Predicted oxidoreductase [General function prediction only]; Region: COG3573 198628002945 FAD binding domain; Region: FAD_binding_2; pfam00890 198628002946 FMN-binding domain; Region: FMN_bind; pfam04205 198628002947 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198628002948 putative substrate translocation pore; other site 198628002949 cytochrome c nitrite reductase, NrfD subunit; Region: cyt_nit_nrfD; TIGR03148 198628002950 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 198628002951 cytochrome c nitrite reductase, Fe-S protein; Region: cyt_nit_nrfC; TIGR03149 198628002952 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 198628002953 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 198628002954 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 198628002955 substrate binding pocket [chemical binding]; other site 198628002956 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 198628002957 Transcriptional regulator [Transcription]; Region: LysR; COG0583 198628002958 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 198628002959 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 198628002960 dimerization interface [polypeptide binding]; other site 198628002961 YdfZ protein; Region: YdfZ; cl11878 198628002962 Transcriptional regulators [Transcription]; Region: PurR; COG1609 198628002963 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 198628002964 DNA binding site [nucleotide binding] 198628002965 domain linker motif; other site 198628002966 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_2; cd06278 198628002967 putative dimerization interface [polypeptide binding]; other site 198628002968 putative ligand binding site [chemical binding]; other site 198628002969 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 198628002970 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 198628002971 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 198628002972 Walker A/P-loop; other site 198628002973 ATP binding site [chemical binding]; other site 198628002974 Q-loop/lid; other site 198628002975 ABC transporter signature motif; other site 198628002976 Walker B; other site 198628002977 D-loop; other site 198628002978 H-loop/switch region; other site 198628002979 TOBE domain; Region: TOBE_2; pfam08402 198628002980 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 198628002981 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198628002982 dimer interface [polypeptide binding]; other site 198628002983 ABC-ATPase subunit interface; other site 198628002984 putative PBP binding loops; other site 198628002985 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198628002986 dimer interface [polypeptide binding]; other site 198628002987 conserved gate region; other site 198628002988 putative PBP binding loops; other site 198628002989 ABC-ATPase subunit interface; other site 198628002990 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 198628002991 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 198628002992 drug efflux system protein MdtG; Provisional; Region: PRK09874 198628002993 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198628002994 putative substrate translocation pore; other site 198628002995 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 198628002996 tartrate dehydrogenase; Region: TTC; TIGR02089 198628002997 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 198628002998 transcriptional activator TtdR; Provisional; Region: PRK09801 198628002999 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479 198628003000 putative effector binding pocket; other site 198628003001 putative dimerization interface [polypeptide binding]; other site 198628003002 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 198628003003 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 198628003004 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 198628003005 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; pfam02592 198628003006 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 198628003007 non-specific DNA binding site [nucleotide binding]; other site 198628003008 salt bridge; other site 198628003009 sequence-specific DNA binding site [nucleotide binding]; other site 198628003010 N-terminal catalytic domain of rhamnogalacturonan lyase, a family 4 polysaccharide lyase; Region: RGL4_N; cd10320 198628003011 active site 198628003012 catalytic site [active] 198628003013 Middle domain of rhamnogalacturonan lyase, a family 4 polysaccharide lyase; Region: RGL4_M; cd10316 198628003014 C-terminal domain of rhamnogalacturonan lyase, a family 4 polysaccharide lyase; Region: RGL4_C; cd10317 198628003015 Ca binding site [ion binding]; other site 198628003016 substrate binding site [chemical binding]; other site 198628003017 hypothetical protein; Provisional; Region: PRK05208 198628003018 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 198628003019 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 198628003020 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 198628003021 dimerization interface [polypeptide binding]; other site 198628003022 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 198628003023 nudix motif; other site 198628003024 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 198628003025 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 198628003026 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 198628003027 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 198628003028 NAD(P) binding site [chemical binding]; other site 198628003029 active site 198628003030 MltA-interacting protein MipA; Region: MipA; cl01504 198628003031 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 198628003032 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 198628003033 active site 198628003034 phosphorylation site [posttranslational modification] 198628003035 intermolecular recognition site; other site 198628003036 dimerization interface [polypeptide binding]; other site 198628003037 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 198628003038 DNA binding site [nucleotide binding] 198628003039 HAMP domain; Region: HAMP; pfam00672 198628003040 His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388 198628003041 dimer interface [polypeptide binding]; other site 198628003042 phosphorylation site [posttranslational modification] 198628003043 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 198628003044 ATP binding site [chemical binding]; other site 198628003045 Mg2+ binding site [ion binding]; other site 198628003046 G-X-G motif; other site 198628003047 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 198628003048 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 198628003049 HlyD family secretion protein; Region: HlyD_3; pfam13437 198628003050 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 198628003051 F plasmid transfer operon, TraF, protein; Region: TraF_2; pfam13729 198628003052 Predicted transcriptional regulators [Transcription]; Region: COG1733 198628003053 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 198628003054 Domain of unknown function (DUF4347); Region: DUF4347; pfam14252 198628003055 CshA-type fibril repeat; Region: CshA_fibril_rpt; TIGR04225 198628003056 CshA-type fibril repeat; Region: CshA_fibril_rpt; TIGR04225 198628003057 CshA-type fibril repeat; Region: CshA_fibril_rpt; TIGR04225 198628003058 CshA-type fibril repeat; Region: CshA_fibril_rpt; TIGR04225 198628003059 CshA-type fibril repeat; Region: CshA_fibril_rpt; TIGR04225 198628003060 CshA-type fibril repeat; Region: CshA_fibril_rpt; TIGR04225 198628003061 Outer membrane efflux protein; Region: OEP; pfam02321 198628003062 Outer membrane efflux protein; Region: OEP; pfam02321 198628003063 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 198628003064 HlyD family secretion protein; Region: HlyD_3; pfam13437 198628003065 Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845 198628003066 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 198628003067 HlyD family secretion protein; Region: HlyD_3; pfam13437 198628003068 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 198628003069 Peptidase family M50; Region: Peptidase_M50; pfam02163 198628003070 active site 198628003071 putative substrate binding region [chemical binding]; other site 198628003072 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 198628003073 HlyD family secretion protein; Region: HlyD_3; pfam13437 198628003074 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 198628003075 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 198628003076 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 198628003077 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 198628003078 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 198628003079 Walker A/P-loop; other site 198628003080 ATP binding site [chemical binding]; other site 198628003081 Q-loop/lid; other site 198628003082 ABC transporter signature motif; other site 198628003083 Walker B; other site 198628003084 D-loop; other site 198628003085 H-loop/switch region; other site 198628003086 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 198628003087 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 198628003088 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 198628003089 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 198628003090 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 198628003091 HlyD family secretion protein; Region: HlyD_3; pfam13437 198628003092 topology modulation protein; Reviewed; Region: PRK08118 198628003093 AAA domain; Region: AAA_17; pfam13207 198628003094 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 198628003096 Fic family protein [Function unknown]; Region: COG3177 198628003097 Fic/DOC family; Region: Fic; pfam02661 198628003098 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 198628003099 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 198628003100 non-specific DNA binding site [nucleotide binding]; other site 198628003101 salt bridge; other site 198628003102 sequence-specific DNA binding site [nucleotide binding]; other site 198628003103 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 198628003104 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 198628003105 non-specific DNA binding site [nucleotide binding]; other site 198628003106 salt bridge; other site 198628003107 sequence-specific DNA binding site [nucleotide binding]; other site 198628003108 Winged helix-turn-helix DNA-binding; Region: HTH_35; pfam13693 198628003109 integrase; Provisional; Region: PRK09692 198628003110 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 198628003111 active site 198628003112 Int/Topo IB signature motif; other site 198628003113 ornithine decarboxylase; Provisional; Region: PRK13578 198628003114 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 198628003115 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 198628003116 homodimer interface [polypeptide binding]; other site 198628003117 pyridoxal 5'-phosphate binding site [chemical binding]; other site 198628003118 catalytic residue [active] 198628003119 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 198628003120 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 198628003121 Transposase; Region: DEDD_Tnp_IS110; pfam01548 198628003122 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 198628003123 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 198628003124 Transposase; Region: DEDD_Tnp_IS110; pfam01548 198628003125 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 198628003126 L-asparagine permease; Provisional; Region: PRK15049 198628003127 murein transglycosylase C; Provisional; Region: mltC; PRK11671 198628003128 Domain of unknown function (DUF3393); Region: DUF3393; pfam11873 198628003129 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 198628003130 N-acetyl-D-glucosamine binding site [chemical binding]; other site 198628003131 catalytic residue [active] 198628003132 oxidative damage protection protein; Provisional; Region: PRK05408 198628003133 adenine DNA glycosylase; Provisional; Region: PRK10880 198628003134 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 198628003135 minor groove reading motif; other site 198628003136 helix-hairpin-helix signature motif; other site 198628003137 substrate binding pocket [chemical binding]; other site 198628003138 active site 198628003139 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 198628003140 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 198628003141 DNA binding and oxoG recognition site [nucleotide binding] 198628003142 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 198628003143 hypothetical protein; Provisional; Region: PRK11702 198628003144 hypothetical protein; Provisional; Region: PRK10626 198628003145 Protein of unknown function (DUF2884); Region: DUF2884; pfam11101 198628003146 Peptidase S8 family domain in Autotransporter serine proteases; Region: Peptidases_S8_Autotransporter_serine_protease_like; cd04848 198628003147 catalytic triad [active] 198628003148 putative active site [active] 198628003149 Uncharacterized protein with a C-terminal OMP (outer membrane protein) domain [Function unknown]; Region: COG4625 198628003150 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 198628003151 Autotransporter beta-domain; Region: Autotransporter; pfam03797 198628003152 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 198628003153 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 198628003154 active site 198628003155 catalytic tetrad [active] 198628003156 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 198628003157 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 198628003158 MutH is a 28kD endonuclease involved in methyl-directed DNA mismatch repair in gram negative bacteria. MutH is both sequence-specific and methylation-specific, introducing a nick in the unmethylated strand of a hemi-methylated d(GATC) DNA duplex. MutH...; Region: MutH_Sau3AI; cd00583 198628003159 putative DNA-binding cleft [nucleotide binding]; other site 198628003160 putative DNA clevage site; other site 198628003161 molecular lever; other site 198628003162 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 198628003163 putative active site [active] 198628003164 Ap4A binding site [chemical binding]; other site 198628003165 nudix motif; other site 198628003166 putative metal binding site [ion binding]; other site 198628003167 fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain; Provisional; Region: PRK11061 198628003168 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 198628003169 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 198628003170 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 198628003171 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 198628003172 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 198628003173 thymidylate synthase; Reviewed; Region: thyA; PRK01827 198628003174 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 198628003175 dimerization interface [polypeptide binding]; other site 198628003176 active site 198628003177 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 198628003178 hypothetical protein; Provisional; Region: PRK10506 198628003179 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 198628003180 hypothetical protein; Provisional; Region: PRK10557 198628003181 Protein of unknown function (DUF2509); Region: DUF2509; cl11672 198628003182 hypothetical protein; Provisional; Region: PRK10332 198628003183 Prepilin peptidase dependent protein C term (DUF3728); Region: DUF3728; pfam12528 198628003184 protease3; Provisional; Region: PRK15101 198628003185 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 198628003186 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 198628003187 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 198628003188 N-acetylglutamate synthase; Validated; Region: PRK05279 198628003189 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 198628003190 putative feedback inhibition sensing region; other site 198628003191 putative nucleotide binding site [chemical binding]; other site 198628003192 putative substrate binding site [chemical binding]; other site 198628003193 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 198628003194 Coenzyme A binding pocket [chemical binding]; other site 198628003195 N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431 198628003196 AMIN domain; Region: AMIN; pfam11741 198628003197 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 198628003198 active site 198628003199 metal binding site [ion binding]; metal-binding site 198628003200 murein transglycosylase A; Provisional; Region: mltA; PRK11162 198628003201 MltA specific insert domain; Region: MltA; smart00925 198628003202 3D domain; Region: 3D; pfam06725 198628003203 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 198628003204 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 198628003205 Coenzyme A binding pocket [chemical binding]; other site 198628003206 Putative D-3-Phosphoglycerate Dehydrogenases; Region: PGDH_like_1; cd12169 198628003207 dimerization interface [polypeptide binding]; other site 198628003208 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 198628003209 NAD binding site [chemical binding]; other site 198628003210 ligand binding site [chemical binding]; other site 198628003211 catalytic site [active] 198628003212 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 198628003213 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 198628003214 Coenzyme A binding pocket [chemical binding]; other site 198628003215 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 198628003216 sulfur acceptor protein CsdL; Provisional; Region: PRK15116 198628003217 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 198628003218 putative ATP binding site [chemical binding]; other site 198628003219 putative substrate interface [chemical binding]; other site 198628003220 Fe-S metabolism associated domain; Region: SufE; cl00951 198628003221 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 198628003222 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 198628003223 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 198628003224 catalytic residue [active] 198628003225 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 198628003226 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 198628003227 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 198628003228 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 198628003229 dimerization interface [polypeptide binding]; other site 198628003230 substrate binding pocket [chemical binding]; other site 198628003231 hypothetical protein; Provisional; Region: PRK10873 198628003232 putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760 198628003233 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 198628003234 flap endonuclease-like protein; Provisional; Region: PRK09482 198628003235 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 198628003236 active site 198628003237 metal binding site 1 [ion binding]; metal-binding site 198628003238 putative 5' ssDNA interaction site; other site 198628003239 metal binding site 3; metal-binding site 198628003240 metal binding site 2 [ion binding]; metal-binding site 198628003241 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 198628003242 putative DNA binding site [nucleotide binding]; other site 198628003243 putative metal binding site [ion binding]; other site 198628003244 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 198628003245 Domain of unknown function (DUF3412); Region: DUF3412; pfam11892 198628003246 SecY interacting protein Syd; Provisional; Region: PRK04968 198628003247 tRNA pseudouridine synthase C; Region: DUF446; pfam04287 198628003248 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 198628003249 tRNA pseudouridine isomerase C; Region: PseudoU_synth_TruC; cd02563 198628003250 probable active site [active] 198628003251 flavodoxin; Provisional; Region: PRK08105 198628003252 hypothetical protein; Provisional; Region: PRK13677 198628003253 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 198628003254 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 198628003255 trimer interface [polypeptide binding]; other site 198628003256 active site 198628003257 substrate binding site [chemical binding]; other site 198628003258 CoA binding site [chemical binding]; other site 198628003259 PII uridylyl-transferase; Provisional; Region: PRK05007 198628003260 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 198628003261 metal binding triad; other site 198628003262 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 198628003263 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 198628003264 Zn2+ binding site [ion binding]; other site 198628003265 Mg2+ binding site [ion binding]; other site 198628003266 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 198628003267 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 198628003268 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 198628003269 active site 198628003270 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 198628003271 rRNA interaction site [nucleotide binding]; other site 198628003272 S8 interaction site; other site 198628003273 putative laminin-1 binding site; other site 198628003274 elongation factor Ts; Provisional; Region: tsf; PRK09377 198628003275 UBA/TS-N domain; Region: UBA; pfam00627 198628003276 Elongation factor TS; Region: EF_TS; pfam00889 198628003277 Elongation factor TS; Region: EF_TS; pfam00889 198628003278 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 198628003279 putative nucleotide binding site [chemical binding]; other site 198628003280 uridine monophosphate binding site [chemical binding]; other site 198628003281 homohexameric interface [polypeptide binding]; other site 198628003282 ribosome recycling factor; Reviewed; Region: frr; PRK00083 198628003283 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 198628003284 hinge region; other site 198628003285 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 198628003286 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 198628003287 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 198628003288 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 198628003289 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 198628003290 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 198628003291 catalytic residue [active] 198628003292 putative FPP diphosphate binding site; other site 198628003293 putative FPP binding hydrophobic cleft; other site 198628003294 dimer interface [polypeptide binding]; other site 198628003295 putative IPP diphosphate binding site; other site 198628003296 CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624 198628003297 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 198628003298 zinc metallopeptidase RseP; Provisional; Region: PRK10779 198628003299 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 198628003300 active site 198628003301 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 198628003302 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 198628003303 protein binding site [polypeptide binding]; other site 198628003304 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 198628003305 putative substrate binding region [chemical binding]; other site 198628003306 outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067 198628003307 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 198628003308 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 198628003309 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 198628003310 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 198628003311 Surface antigen; Region: Bac_surface_Ag; pfam01103 198628003312 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: HlpA; COG2825 198628003313 periplasmic chaperone; Provisional; Region: PRK10780 198628003314 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 198628003315 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 198628003316 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 198628003317 trimer interface [polypeptide binding]; other site 198628003318 active site 198628003319 UDP-GlcNAc binding site [chemical binding]; other site 198628003320 lipid binding site [chemical binding]; lipid-binding site 198628003321 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 198628003322 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 198628003323 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 198628003324 active site 198628003325 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 198628003326 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 198628003327 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 198628003328 RNA/DNA hybrid binding site [nucleotide binding]; other site 198628003329 active site 198628003330 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 198628003331 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 198628003332 putative active site [active] 198628003333 putative PHP Thumb interface [polypeptide binding]; other site 198628003334 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 198628003335 generic binding surface II; other site 198628003336 generic binding surface I; other site 198628003337 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 198628003338 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 198628003339 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 198628003340 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 198628003341 putative metal binding site [ion binding]; other site 198628003342 tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660 198628003343 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 198628003344 Ligand Binding Site [chemical binding]; other site 198628003345 TilS substrate binding domain; Region: TilS; pfam09179 198628003346 TilS substrate C-terminal domain; Region: TilS_C; pfam11734 198628003347 Rho-binding antiterminator; Provisional; Region: PRK11625 198628003348 hypothetical protein; Provisional; Region: PRK04964 198628003349 YaeQ protein; Region: YaeQ; pfam07152 198628003350 NlpE N-terminal domain; Region: NlpE; pfam04170 198628003351 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 198628003352 MutS domain I; Region: MutS_I; pfam01624 198628003353 MutS domain II; Region: MutS_II; pfam05188 198628003354 MutS domain III; Region: MutS_III; pfam05192 198628003355 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 198628003356 Walker A/P-loop; other site 198628003357 ATP binding site [chemical binding]; other site 198628003358 Q-loop/lid; other site 198628003359 ABC transporter signature motif; other site 198628003360 Walker B; other site 198628003361 D-loop; other site 198628003362 H-loop/switch region; other site 198628003363 Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136 198628003364 putative FMN binding site [chemical binding]; other site 198628003365 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 198628003366 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 198628003367 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 198628003368 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 198628003369 dimerization interface [polypeptide binding]; other site 198628003370 putative Zn2+ binding site [ion binding]; other site 198628003371 putative DNA binding site [nucleotide binding]; other site 198628003372 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 198628003373 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 198628003374 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 198628003375 substrate binding site [chemical binding]; other site 198628003376 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 198628003377 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 198628003378 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 198628003379 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 1; Region: PLPDE_III_DSD_D-TA_like_1; cd06812 198628003380 dimer interface [polypeptide binding]; other site 198628003381 active site 198628003382 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 198628003383 substrate binding site [chemical binding]; other site 198628003384 catalytic residue [active] 198628003385 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 198628003386 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 198628003387 dimerization interface [polypeptide binding]; other site 198628003388 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198628003389 Major Facilitator Superfamily; Region: MFS_1; pfam07690 198628003390 putative substrate translocation pore; other site 198628003391 Pyoverdine/dityrosine biosynthesis protein; Region: DIT1_PvcA; pfam05141 198628003392 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 198628003393 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 198628003394 motif II; other site 198628003395 Pyoverdine/dityrosine biosynthesis protein; Region: DIT1_PvcA; pfam05141 198628003396 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 198628003397 H+ Antiporter protein; Region: 2A0121; TIGR00900 198628003398 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198628003399 putative substrate translocation pore; other site 198628003400 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 198628003401 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 198628003402 PhnA protein; Region: PhnA; pfam03831 198628003403 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 198628003404 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 198628003405 metal binding site [ion binding]; metal-binding site 198628003406 active site 198628003407 I-site; other site 198628003408 Domain of unknown function (DUF1987); Region: DUF1987; pfam09345 198628003409 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the GGDEF (DiGuanylate-Cyclase (DGC)) domain. The GGDEF domain has been suggested to be homologous to the adenylyl cyclase catalytic domain and...; Region: CBS_pair_GGDEF_assoc; cd04598 198628003410 FOG: CBS domain [General function prediction only]; Region: COG0517 198628003411 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 198628003412 Transcriptional regulator [Transcription]; Region: LysR; COG0583 198628003413 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 198628003414 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 198628003415 dimerization interface [polypeptide binding]; other site 198628003416 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 198628003417 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 198628003418 Major Facilitator Superfamily; Region: MFS_1; pfam07690 198628003419 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198628003420 putative substrate translocation pore; other site 198628003421 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198628003422 metabolite-proton symporter; Region: 2A0106; TIGR00883 198628003423 putative substrate translocation pore; other site 198628003424 hypothetical protein; Provisional; Region: PRK07079 198628003425 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_2; cd05679 198628003426 metal binding site [ion binding]; metal-binding site 198628003427 putative dimer interface [polypeptide binding]; other site 198628003428 Transcriptional regulator [Transcription]; Region: LysR; COG0583 198628003429 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 198628003430 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 198628003431 dimerization interface [polypeptide binding]; other site 198628003432 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 198628003433 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 198628003434 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 198628003435 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 198628003436 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 198628003437 substrate binding site [chemical binding]; other site 198628003438 THF binding site; other site 198628003439 zinc-binding site [ion binding]; other site 198628003440 multidrug transporter membrane component/ATP-binding component; Provisional; Region: PRK10522 198628003441 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 198628003442 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 198628003443 Walker A/P-loop; other site 198628003444 ATP binding site [chemical binding]; other site 198628003445 Q-loop/lid; other site 198628003446 ABC transporter signature motif; other site 198628003447 Walker B; other site 198628003448 D-loop; other site 198628003449 H-loop/switch region; other site 198628003450 Bacterial L-asparaginases and related enzymes; Region: L-asparaginase_like; cd00411 198628003451 active site 198628003452 homodimer interface [polypeptide binding]; other site 198628003453 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 198628003454 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 198628003455 ADP binding site [chemical binding]; other site 198628003456 magnesium binding site [ion binding]; other site 198628003457 putative shikimate binding site; other site 198628003458 hypothetical protein; Provisional; Region: PRK10579 198628003459 Cache domain; Region: Cache_1; pfam02743 198628003460 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 198628003461 dimerization interface [polypeptide binding]; other site 198628003462 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 198628003463 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 198628003464 dimer interface [polypeptide binding]; other site 198628003465 putative CheW interface [polypeptide binding]; other site 198628003466 recombination associated protein; Reviewed; Region: rdgC; PRK00321 198628003467 fructokinase; Reviewed; Region: PRK09557 198628003468 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 198628003469 nucleotide binding site [chemical binding]; other site 198628003470 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 198628003471 AAA domain; Region: AAA_23; pfam13476 198628003472 Walker A/P-loop; other site 198628003473 ATP binding site [chemical binding]; other site 198628003474 Q-loop/lid; other site 198628003475 exonuclease subunit SbcC; Provisional; Region: PRK10246 198628003476 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 198628003477 ABC transporter signature motif; other site 198628003478 Walker B; other site 198628003479 D-loop; other site 198628003480 H-loop/switch region; other site 198628003481 exonuclease subunit SbcD; Provisional; Region: PRK10966 198628003482 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 198628003483 active site 198628003484 metal binding site [ion binding]; metal-binding site 198628003485 DNA binding site [nucleotide binding] 198628003486 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 198628003487 transcriptional regulator PhoB; Provisional; Region: PRK10161 198628003488 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 198628003489 active site 198628003490 phosphorylation site [posttranslational modification] 198628003491 intermolecular recognition site; other site 198628003492 dimerization interface [polypeptide binding]; other site 198628003493 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 198628003494 DNA binding site [nucleotide binding] 198628003495 phosphate regulon sensor protein; Provisional; Region: phoR; PRK11006 198628003496 Domain of unknown function (DUF3329); Region: DUF3329; pfam11808 198628003497 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 198628003498 putative active site [active] 198628003499 heme pocket [chemical binding]; other site 198628003500 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 198628003501 dimer interface [polypeptide binding]; other site 198628003502 phosphorylation site [posttranslational modification] 198628003503 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 198628003504 ATP binding site [chemical binding]; other site 198628003505 Mg2+ binding site [ion binding]; other site 198628003506 G-X-G motif; other site 198628003507 PBP superfamily domain; Region: PBP_like_2; cl17296 198628003508 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 198628003509 substrate binding site [chemical binding]; other site 198628003510 THF binding site; other site 198628003511 zinc-binding site [ion binding]; other site 198628003512 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 198628003513 putative proline-specific permease; Provisional; Region: proY; PRK10580 198628003514 Spore germination protein; Region: Spore_permease; cl17796 198628003515 peroxidase; Provisional; Region: PRK15000 198628003516 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 198628003517 dimer interface [polypeptide binding]; other site 198628003518 decamer (pentamer of dimers) interface [polypeptide binding]; other site 198628003519 catalytic triad [active] 198628003520 peroxidatic and resolving cysteines [active] 198628003521 Protein of unknown function, DUF479; Region: DUF479; cl01203 198628003522 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 198628003523 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 198628003524 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 198628003525 tRNA-guanine family transglycosylase; Region: tgt_general; TIGR00449 198628003526 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 198628003527 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 198628003528 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 198628003529 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 198628003530 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 198628003531 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 198628003532 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 198628003533 Protein export membrane protein; Region: SecD_SecF; pfam02355 198628003534 hypothetical protein; Provisional; Region: PRK11530 198628003535 magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517 198628003536 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 198628003537 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 198628003538 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 198628003539 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 198628003540 Soluble P-type ATPase [General function prediction only]; Region: COG4087 198628003541 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 198628003542 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 198628003543 ATP cone domain; Region: ATP-cone; pfam03477 198628003544 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 198628003545 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 198628003546 catalytic motif [active] 198628003547 Zn binding site [ion binding]; other site 198628003548 RibD C-terminal domain; Region: RibD_C; cl17279 198628003549 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 198628003550 homopentamer interface [polypeptide binding]; other site 198628003551 active site 198628003552 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 198628003553 putative RNA binding site [nucleotide binding]; other site 198628003554 thiamine monophosphate kinase; Provisional; Region: PRK05731 198628003555 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 198628003556 ATP binding site [chemical binding]; other site 198628003557 dimerization interface [polypeptide binding]; other site 198628003558 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 198628003559 tetramer interfaces [polypeptide binding]; other site 198628003560 binuclear metal-binding site [ion binding]; other site 198628003561 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 198628003562 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 198628003563 TPP-binding site; other site 198628003564 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 198628003565 PYR/PP interface [polypeptide binding]; other site 198628003566 dimer interface [polypeptide binding]; other site 198628003567 TPP binding site [chemical binding]; other site 198628003568 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 198628003569 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 198628003570 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 198628003571 substrate binding pocket [chemical binding]; other site 198628003572 chain length determination region; other site 198628003573 substrate-Mg2+ binding site; other site 198628003574 catalytic residues [active] 198628003575 aspartate-rich region 1; other site 198628003576 active site lid residues [active] 198628003577 aspartate-rich region 2; other site 198628003578 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 198628003579 tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269 198628003580 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 198628003581 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 198628003582 Ligand Binding Site [chemical binding]; other site 198628003583 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 198628003584 active site residue [active] 198628003585 oxidative-stress-resistance chaperone; Provisional; Region: PRK11574 198628003586 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 198628003587 conserved cys residue [active] 198628003588 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 198628003589 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 198628003590 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 198628003591 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 198628003592 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 198628003593 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 198628003594 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 198628003595 active site 198628003596 catalytic tetrad [active] 198628003597 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 198628003598 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198628003599 Major Facilitator Superfamily; Region: MFS_1; pfam07690 198628003600 putative substrate translocation pore; other site 198628003601 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 198628003602 atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262 198628003603 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 198628003604 putative NAD(P) binding site [chemical binding]; other site 198628003605 Cupin; Region: Cupin_6; pfam12852 198628003606 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 198628003607 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 198628003608 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 198628003609 protoheme IX farnesyltransferase; Provisional; Region: PRK13362 198628003610 UbiA prenyltransferase family; Region: UbiA; pfam01040 198628003611 cytochrome o ubiquinol oxidase subunit IV; Provisional; Region: PRK10582 198628003612 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 198628003613 Subunit I/III interface [polypeptide binding]; other site 198628003614 Subunit III/IV interface [polypeptide binding]; other site 198628003615 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 198628003616 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 198628003617 D-pathway; other site 198628003618 Putative ubiquinol binding site [chemical binding]; other site 198628003619 Low-spin heme (heme b) binding site [chemical binding]; other site 198628003620 Putative water exit pathway; other site 198628003621 Binuclear center (heme o3/CuB) [ion binding]; other site 198628003622 K-pathway; other site 198628003623 Putative proton exit pathway; other site 198628003624 cytochrome o ubiquinol oxidase subunit II; Provisional; Region: PRK10525 198628003625 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 198628003626 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 198628003627 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198628003628 muropeptide transporter; Reviewed; Region: ampG; PRK11902 198628003629 putative substrate translocation pore; other site 198628003630 hypothetical protein; Provisional; Region: PRK11627 198628003631 Uncharacterized lipoprotein; Region: Lipoprotein_16; pfam03923 198628003632 BolA-like protein; Region: BolA; cl00386 198628003633 trigger factor; Provisional; Region: tig; PRK01490 198628003634 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 198628003635 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 198628003636 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 198628003637 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 198628003638 oligomer interface [polypeptide binding]; other site 198628003639 active site residues [active] 198628003640 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 198628003641 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 198628003642 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 198628003643 Walker A motif; other site 198628003644 ATP binding site [chemical binding]; other site 198628003645 Walker B motif; other site 198628003646 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 198628003647 DNA-binding ATP-dependent protease La; Provisional; Region: PRK10787 198628003648 Found in ATP-dependent protease La (LON); Region: LON; smart00464 198628003649 Found in ATP-dependent protease La (LON); Region: LON; smart00464 198628003650 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 198628003651 Walker A motif; other site 198628003652 ATP binding site [chemical binding]; other site 198628003653 Walker B motif; other site 198628003654 arginine finger; other site 198628003655 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 198628003656 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 198628003657 IHF dimer interface [polypeptide binding]; other site 198628003658 IHF - DNA interface [nucleotide binding]; other site 198628003659 periplasmic folding chaperone; Provisional; Region: PRK10788 198628003660 SurA N-terminal domain; Region: SurA_N_3; cl07813 198628003661 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 198628003662 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 198628003663 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 198628003664 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 198628003665 Ligand Binding Site [chemical binding]; other site 198628003666 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 198628003667 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 198628003668 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 198628003669 catalytic residue [active] 198628003670 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 198628003671 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 198628003672 putative DNA binding site [nucleotide binding]; other site 198628003673 putative Zn2+ binding site [ion binding]; other site 198628003674 AsnC family; Region: AsnC_trans_reg; pfam01037 198628003675 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 198628003676 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 198628003677 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 198628003678 Walker A/P-loop; other site 198628003679 ATP binding site [chemical binding]; other site 198628003680 Q-loop/lid; other site 198628003681 ABC transporter signature motif; other site 198628003682 Walker B; other site 198628003683 D-loop; other site 198628003684 H-loop/switch region; other site 198628003685 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10790 198628003686 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 198628003687 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 198628003688 Walker A/P-loop; other site 198628003689 ATP binding site [chemical binding]; other site 198628003690 Q-loop/lid; other site 198628003691 ABC transporter signature motif; other site 198628003692 Walker B; other site 198628003693 D-loop; other site 198628003694 H-loop/switch region; other site 198628003695 nitrogen regulatory protein P-II 2; Provisional; Region: PRK10665 198628003696 Nitrogen regulatory protein P-II; Region: P-II; smart00938 198628003697 ammonium transporter; Provisional; Region: PRK10666 198628003698 acyl-CoA thioesterase II; Provisional; Region: PRK10526 198628003699 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 198628003700 active site 198628003701 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 198628003702 catalytic triad [active] 198628003703 dimer interface [polypeptide binding]; other site 198628003704 Type III secretion system lipoprotein chaperone (YscW); Region: YscW; pfam09619 198628003705 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 198628003706 DNA binding site [nucleotide binding] 198628003707 active site 198628003708 gene expression modulator; Provisional; Region: PRK10945 198628003709 Hha toxicity attenuator; Provisional; Region: PRK10667 198628003710 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 198628003711 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 198628003712 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 198628003713 Protein export membrane protein; Region: SecD_SecF; cl14618 198628003714 Protein export membrane protein; Region: SecD_SecF; cl14618 198628003715 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 198628003716 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 198628003717 HlyD family secretion protein; Region: HlyD_3; pfam13437 198628003718 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 198628003719 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 198628003720 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 198628003721 hypothetical protein; Provisional; Region: PRK11281 198628003722 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 198628003723 Mechanosensitive ion channel; Region: MS_channel; pfam00924 198628003724 hypothetical protein; Provisional; Region: PRK11038 198628003725 Primosomal replication protein priB and priC; Region: priB_priC; cl11483 198628003726 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 198628003727 active site 198628003728 dinuclear metal binding site [ion binding]; other site 198628003729 dimerization interface [polypeptide binding]; other site 198628003730 hypothetical protein; Provisional; Region: PRK10527 198628003731 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 198628003732 active site 198628003733 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994 198628003734 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 198628003735 Walker A motif; other site 198628003736 ATP binding site [chemical binding]; other site 198628003737 Walker B motif; other site 198628003738 arginine finger; other site 198628003739 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 198628003740 DNA polymerase III subunits tau domain IV DnaB-binding; Region: DNA_pol3_tau_4; pfam12168 198628003741 DNA polymerase III tau subunit V interacting with alpha; Region: DNA_pol3_tau_5; pfam12170 198628003742 hypothetical protein; Validated; Region: PRK00153 198628003743 recombination protein RecR; Reviewed; Region: recR; PRK00076 198628003744 RecR protein; Region: RecR; pfam02132 198628003745 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 198628003746 putative active site [active] 198628003747 putative metal-binding site [ion binding]; other site 198628003748 tetramer interface [polypeptide binding]; other site 198628003749 heat shock protein 90; Provisional; Region: PRK05218 198628003750 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 198628003751 ATP binding site [chemical binding]; other site 198628003752 Mg2+ binding site [ion binding]; other site 198628003753 G-X-G motif; other site 198628003754 adenylate kinase; Reviewed; Region: adk; PRK00279 198628003755 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 198628003756 AMP-binding site [chemical binding]; other site 198628003757 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 198628003758 ferrochelatase; Reviewed; Region: hemH; PRK00035 198628003759 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 198628003760 C-terminal domain interface [polypeptide binding]; other site 198628003761 active site 198628003762 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 198628003763 active site 198628003764 N-terminal domain interface [polypeptide binding]; other site 198628003765 Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651 198628003766 putative cation:proton antiport protein; Provisional; Region: PRK10669 198628003767 TrkA-N domain; Region: TrkA_N; pfam02254 198628003768 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558 198628003769 Escherichia coli UshA and related proteins, N-terminal metallophosphatase domain; Region: MPP_UshA_N; cd07405 198628003770 active site 198628003771 metal binding site [ion binding]; metal-binding site 198628003772 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 198628003773 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 198628003774 HAMP domain; Region: HAMP; pfam00672 198628003775 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 198628003776 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 198628003777 dimer interface [polypeptide binding]; other site 198628003778 putative CheW interface [polypeptide binding]; other site 198628003779 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 198628003780 Glycosyl hydrolases family 28; Region: Glyco_hydro_28; pfam00295 198628003781 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 198628003782 putative deacylase active site [active] 198628003783 TraB family; Region: TraB; cl12050 198628003784 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 198628003785 metal-binding site [ion binding] 198628003786 copper exporting ATPase; Provisional; Region: copA; PRK10671 198628003787 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 198628003788 metal-binding site [ion binding] 198628003789 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 198628003790 metal-binding site [ion binding] 198628003791 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 198628003792 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 198628003793 motif II; other site 198628003794 DNA-binding transcriptional regulator CueR; Provisional; Region: PRK10227 198628003795 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 198628003796 DNA binding residues [nucleotide binding] 198628003797 dimer interface [polypeptide binding]; other site 198628003798 copper binding site [ion binding]; other site 198628003799 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 198628003800 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 198628003801 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 198628003802 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 198628003803 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 198628003804 catalytic loop [active] 198628003805 iron binding site [ion binding]; other site 198628003806 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 198628003807 dimer interface [polypeptide binding]; other site 198628003808 putative radical transfer pathway; other site 198628003809 diiron center [ion binding]; other site 198628003810 tyrosyl radical; other site 198628003811 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103 198628003812 ATP cone domain; Region: ATP-cone; pfam03477 198628003813 Class I ribonucleotide reductase; Region: RNR_I; cd01679 198628003814 active site 198628003815 dimer interface [polypeptide binding]; other site 198628003816 catalytic residues [active] 198628003817 effector binding site; other site 198628003818 R2 peptide binding site; other site 198628003819 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 198628003820 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 198628003821 S-adenosylmethionine binding site [chemical binding]; other site 198628003822 DNA gyrase subunit A; Validated; Region: PRK05560 198628003823 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 198628003824 CAP-like domain; other site 198628003825 active site 198628003826 primary dimer interface [polypeptide binding]; other site 198628003827 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 198628003828 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 198628003829 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 198628003830 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 198628003831 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 198628003832 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 198628003833 hybrid sensory kinase in two-component regulatory system with RcsB and YojN; Provisional; Region: PRK10841 198628003834 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 198628003835 dimer interface [polypeptide binding]; other site 198628003836 phosphorylation site [posttranslational modification] 198628003837 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 198628003838 ATP binding site [chemical binding]; other site 198628003839 Mg2+ binding site [ion binding]; other site 198628003840 G-X-G motif; other site 198628003841 RcsC Alpha-Beta-Loop (ABL); Region: RcsC; pfam09456 198628003842 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 198628003843 active site 198628003844 phosphorylation site [posttranslational modification] 198628003845 intermolecular recognition site; other site 198628003846 dimerization interface [polypeptide binding]; other site 198628003847 transcriptional regulator RcsB; Provisional; Region: PRK10840 198628003848 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 198628003849 active site 198628003850 phosphorylation site [posttranslational modification] 198628003851 intermolecular recognition site; other site 198628003852 dimerization interface [polypeptide binding]; other site 198628003853 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 198628003854 DNA binding residues [nucleotide binding] 198628003855 dimerization interface [polypeptide binding]; other site 198628003856 phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional; Region: PRK10618 198628003857 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 198628003858 dimer interface [polypeptide binding]; other site 198628003859 phosphorylation site [posttranslational modification] 198628003860 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 198628003861 ATP binding site [chemical binding]; other site 198628003862 G-X-G motif; other site 198628003863 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 198628003864 putative binding surface; other site 198628003865 active site 198628003866 menaquinone-specific isochorismate synthase; Provisional; Region: PRK15012 198628003867 chorismate binding enzyme; Region: Chorismate_bind; cl10555 198628003868 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 198628003869 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 198628003870 dimer interface [polypeptide binding]; other site 198628003871 tetramer interface [polypeptide binding]; other site 198628003872 PYR/PP interface [polypeptide binding]; other site 198628003873 TPP binding site [chemical binding]; other site 198628003874 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 198628003875 TPP-binding site; other site 198628003876 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Provisional; Region: PRK11126 198628003877 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 198628003878 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 198628003879 substrate binding site [chemical binding]; other site 198628003880 oxyanion hole (OAH) forming residues; other site 198628003881 trimer interface [polypeptide binding]; other site 198628003882 O-succinylbenzoate synthase; Provisional; Region: PRK05105 198628003883 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 198628003884 active site 198628003885 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK09029 198628003886 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 198628003887 acyl-activating enzyme (AAE) consensus motif; other site 198628003888 putative AMP binding site [chemical binding]; other site 198628003889 putative active site [active] 198628003890 putative CoA binding site [chemical binding]; other site 198628003891 YfaZ precursor; Region: YfaZ; pfam07437 198628003892 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 198628003893 hypothetical protein; Provisional; Region: PRK03673 198628003894 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 198628003895 putative MPT binding site; other site 198628003896 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 198628003897 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 198628003898 oxidoreductase; Provisional; Region: PRK08017 198628003899 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 198628003900 NADP binding site [chemical binding]; other site 198628003901 active site 198628003902 steroid binding site; other site 198628003903 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 198628003904 active site 198628003905 catalytic triad [active] 198628003906 oxyanion hole [active] 198628003907 switch loop; other site 198628003908 putative ABC transporter ATP-binding protein YbbA; Provisional; Region: PRK10584 198628003909 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 198628003910 Walker A/P-loop; other site 198628003911 ATP binding site [chemical binding]; other site 198628003912 Q-loop/lid; other site 198628003913 ABC transporter signature motif; other site 198628003914 Walker B; other site 198628003915 D-loop; other site 198628003916 H-loop/switch region; other site 198628003917 FtsX-like permease family; Region: FtsX; pfam02687 198628003918 spermidine N1-acetyltransferase; Provisional; Region: PRK15130 198628003919 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 198628003920 Coenzyme A binding pocket [chemical binding]; other site 198628003921 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 198628003922 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 198628003923 N-terminal plug; other site 198628003924 ligand-binding site [chemical binding]; other site 198628003925 ferrichrome/ferrioxamine B periplasmic transporter; Provisional; Region: PRK14048 198628003926 Periplasmic binding protein TroA_f. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_f; cd01139 198628003927 putative ligand binding residues [chemical binding]; other site 198628003928 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 198628003929 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198628003930 dimer interface [polypeptide binding]; other site 198628003931 conserved gate region; other site 198628003932 putative PBP binding loops; other site 198628003933 ABC-ATPase subunit interface; other site 198628003934 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 198628003935 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 198628003936 substrate binding pocket [chemical binding]; other site 198628003937 membrane-bound complex binding site; other site 198628003938 hinge residues; other site 198628003939 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 198628003940 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 198628003941 TM-ABC transporter signature motif; other site 198628003942 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 198628003943 galactose/methyl galaxtoside transporter ATP-binding protein; Provisional; Region: PRK10982 198628003944 Walker A/P-loop; other site 198628003945 ATP binding site [chemical binding]; other site 198628003946 Q-loop/lid; other site 198628003947 ABC transporter signature motif; other site 198628003948 Walker B; other site 198628003949 D-loop; other site 198628003950 H-loop/switch region; other site 198628003951 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 198628003952 methyl-galactoside ABC transporter galactose-binding periplasmic protein MglB; Provisional; Region: PRK15395 198628003953 Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539 198628003954 ligand binding site [chemical binding]; other site 198628003955 calcium binding site [ion binding]; other site 198628003956 DNA-binding transcriptional regulator GalS; Provisional; Region: PRK10401 198628003957 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 198628003958 DNA binding site [nucleotide binding] 198628003959 domain linker motif; other site 198628003960 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 198628003961 dimerization interface (closed form) [polypeptide binding]; other site 198628003962 ligand binding site [chemical binding]; other site 198628003963 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 198628003964 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 198628003965 active site 198628003966 substrate binding site [chemical binding]; other site 198628003967 cosubstrate binding site; other site 198628003968 catalytic site [active] 198628003969 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 198628003970 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 198628003971 dimerization interface [polypeptide binding]; other site 198628003972 putative ATP binding site [chemical binding]; other site 198628003973 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 198628003974 active site 198628003975 uracil transporter; Provisional; Region: PRK10720 198628003976 DNA replication initiation factor; Provisional; Region: PRK08084 198628003977 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 198628003978 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 198628003979 ArsC family; Region: ArsC; pfam03960 198628003980 catalytic residues [active] 198628003981 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 198628003982 Peptidase family M48; Region: Peptidase_M48; pfam01435 198628003983 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 198628003984 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 198628003985 catalytic triad [active] 198628003986 glycine cleavage system transcriptional repressor; Provisional; Region: gcvR; PRK11589 198628003987 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_1; cd04893 198628003988 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 198628003989 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 198628003990 dihydrodipicolinate synthase; Region: dapA; TIGR00674 198628003991 dimer interface [polypeptide binding]; other site 198628003992 active site 198628003993 catalytic residue [active] 198628003994 lipoprotein; Provisional; Region: PRK11679 198628003995 NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804 198628003996 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 198628003997 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 198628003998 ATP binding site [chemical binding]; other site 198628003999 active site 198628004000 substrate binding site [chemical binding]; other site 198628004001 Predicted membrane protein [Function unknown]; Region: COG2707 198628004002 Predicted P-loop ATPase fused to an acetyltransferase [General function prediction only]; Region: COG1444 198628004003 Helicase; Region: Helicase_RecD; pfam05127 198628004004 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 198628004005 Possible tRNA binding domain; Region: tRNA_bind_2; pfam13725 198628004006 putative hydrolase; Provisional; Region: PRK11460 198628004007 Predicted esterase [General function prediction only]; Region: COG0400 198628004008 Uncharacterized protein family (UPF0370); Region: UPF0370; pfam13980 198628004009 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 198628004010 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 198628004011 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 198628004012 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 198628004013 metal binding site [ion binding]; metal-binding site 198628004014 dimer interface [polypeptide binding]; other site 198628004015 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 198628004016 ArsC family; Region: ArsC; pfam03960 198628004017 putative catalytic residues [active] 198628004018 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 198628004019 DNA-binding site [nucleotide binding]; DNA binding site 198628004020 RNA-binding motif; other site 198628004021 Transposase IS200 like; Region: Y1_Tnp; pfam01797 198628004022 chromosome condensation membrane protein; Provisional; Region: PRK14196 198628004023 Predicted amidohydrolase [General function prediction only]; Region: COG0388 198628004024 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 198628004025 putative active site [active] 198628004026 catalytic triad [active] 198628004027 putative dimer interface [polypeptide binding]; other site 198628004028 twin arginine translocase protein E; Validated; Region: tatE; PRK03625 198628004029 lipoyl synthase; Provisional; Region: PRK05481 198628004030 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 198628004031 FeS/SAM binding site; other site 198628004032 lipoate-protein ligase B; Provisional; Region: PRK14342 198628004033 hypothetical protein; Provisional; Region: PRK04998 198628004034 D-alanyl-D-alanine carboxypeptidase fraction A; Provisional; Region: PRK10793 198628004035 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 198628004036 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 198628004037 rare lipoprotein A; Provisional; Region: PRK10672 198628004038 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 198628004039 Sporulation related domain; Region: SPOR; pfam05036 198628004040 cell wall shape-determining protein; Provisional; Region: PRK10794 198628004041 penicillin-binding protein 2; Provisional; Region: PRK10795 198628004042 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 198628004043 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 198628004044 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 198628004045 ribosome-associated protein; Provisional; Region: PRK11538 198628004046 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 198628004047 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 198628004048 active site 198628004049 (T/H)XGH motif; other site 198628004050 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 198628004051 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 198628004052 LPS-assembly lipoprotein RlpB; Provisional; Region: PRK10796 198628004053 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 198628004054 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 198628004055 HIGH motif; other site 198628004056 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 198628004057 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 198628004058 active site 198628004059 KMSKS motif; other site 198628004060 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 198628004061 tRNA binding surface [nucleotide binding]; other site 198628004062 hypothetical protein; Provisional; Region: PRK11032 198628004063 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 198628004064 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 198628004065 Walker A/P-loop; other site 198628004066 ATP binding site [chemical binding]; other site 198628004067 Q-loop/lid; other site 198628004068 ABC transporter signature motif; other site 198628004069 Walker B; other site 198628004070 D-loop; other site 198628004071 H-loop/switch region; other site 198628004072 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 198628004073 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198628004074 dimer interface [polypeptide binding]; other site 198628004075 conserved gate region; other site 198628004076 putative PBP binding loops; other site 198628004077 ABC-ATPase subunit interface; other site 198628004078 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 198628004079 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198628004080 dimer interface [polypeptide binding]; other site 198628004081 conserved gate region; other site 198628004082 putative PBP binding loops; other site 198628004083 ABC-ATPase subunit interface; other site 198628004084 glutamate and aspartate transporter subunit; Provisional; Region: PRK10797 198628004085 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 198628004086 substrate binding pocket [chemical binding]; other site 198628004087 membrane-bound complex binding site; other site 198628004088 hinge residues; other site 198628004089 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 198628004090 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 198628004091 putative active site [active] 198628004092 catalytic triad [active] 198628004093 putative dimer interface [polypeptide binding]; other site 198628004094 magnesium/cobalt efflux protein CorC; Provisional; Region: PRK15094 198628004095 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 198628004096 Transporter associated domain; Region: CorC_HlyC; smart01091 198628004097 metal-binding heat shock protein; Provisional; Region: PRK00016 198628004098 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 198628004099 PhoH-like protein; Region: PhoH; pfam02562 198628004100 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 198628004101 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 198628004102 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 198628004103 FeS/SAM binding site; other site 198628004104 TRAM domain; Region: TRAM; pfam01938 198628004105 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Reviewed; Region: ubiF; PRK08020 198628004106 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 198628004107 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 198628004109 MarR family; Region: MarR; pfam01047 198628004110 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 198628004111 ROK family; Region: ROK; pfam00480 198628004112 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 198628004113 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 198628004114 active site 198628004115 dimer interface [polypeptide binding]; other site 198628004116 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 198628004117 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 198628004118 active site 198628004119 trimer interface [polypeptide binding]; other site 198628004120 allosteric site; other site 198628004121 active site lid [active] 198628004122 hexamer (dimer of trimers) interface [polypeptide binding]; other site 198628004123 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 198628004124 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 198628004125 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 198628004126 active site turn [active] 198628004127 phosphorylation site [posttranslational modification] 198628004128 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 198628004129 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 198628004130 active site 198628004131 HIGH motif; other site 198628004132 nucleotide binding site [chemical binding]; other site 198628004133 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 198628004134 KMSKS motif; other site 198628004135 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 198628004136 ferric uptake regulator; Provisional; Region: fur; PRK09462 198628004137 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 198628004138 metal binding site 2 [ion binding]; metal-binding site 198628004139 putative DNA binding helix; other site 198628004140 metal binding site 1 [ion binding]; metal-binding site 198628004141 dimer interface [polypeptide binding]; other site 198628004142 structural Zn2+ binding site [ion binding]; other site 198628004143 flavodoxin FldA; Validated; Region: PRK09267 198628004144 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 198628004145 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 198628004146 dimer interface [polypeptide binding]; other site 198628004147 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 198628004148 putative CheW interface [polypeptide binding]; other site 198628004149 LexA regulated protein; Provisional; Region: PRK11675 198628004150 acyl-CoA esterase; Provisional; Region: PRK10673 198628004151 PGAP1-like protein; Region: PGAP1; pfam07819 198628004152 replication initiation regulator SeqA; Provisional; Region: PRK11187 198628004153 phosphoglucomutase; Validated; Region: PRK07564 198628004154 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 198628004155 active site 198628004156 substrate binding site [chemical binding]; other site 198628004157 metal binding site [ion binding]; metal-binding site 198628004158 Predicted membrane protein [Function unknown]; Region: COG2510 198628004159 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 198628004160 intermolecular recognition site; other site 198628004161 active site 198628004162 dimerization interface [polypeptide binding]; other site 198628004163 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 198628004164 DNA binding site [nucleotide binding] 198628004165 sensor protein KdpD; Provisional; Region: PRK10490 198628004166 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 198628004167 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 198628004168 Ligand Binding Site [chemical binding]; other site 198628004169 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 198628004170 GAF domain; Region: GAF_3; pfam13492 198628004171 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 198628004172 dimer interface [polypeptide binding]; other site 198628004173 phosphorylation site [posttranslational modification] 198628004174 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 198628004175 ATP binding site [chemical binding]; other site 198628004176 Mg2+ binding site [ion binding]; other site 198628004177 G-X-G motif; other site 198628004178 potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315 198628004179 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 198628004180 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 198628004181 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 198628004182 Protein of unknown function (DUF2517); Region: DUF2517; pfam10725 198628004183 Protein of unknown function (DUF523); Region: DUF523; pfam04463 198628004184 Uncharacterized conserved protein [Function unknown]; Region: COG3272 198628004185 Protein of unknown function (DUF1722); Region: DUF1722; cl01284 198628004186 deoxyribodipyrimidine photolyase; Provisional; Region: PRK10674 198628004187 DNA photolyase; Region: DNA_photolyase; pfam00875 198628004188 Uncharacterized conserved protein [Function unknown]; Region: COG0327 198628004189 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 198628004190 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 198628004191 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 198628004192 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 198628004193 LamB/YcsF family protein; Provisional; Region: PRK05406 198628004194 endonuclease VIII; Provisional; Region: PRK10445 198628004195 N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: FpgNei_N; cl03119 198628004196 DNA binding site [nucleotide binding] 198628004197 catalytic residue [active] 198628004198 H2TH interface [polypeptide binding]; other site 198628004199 putative catalytic residues [active] 198628004200 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 198628004201 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 198628004202 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 198628004203 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 198628004204 dimer interface [polypeptide binding]; other site 198628004205 active site 198628004206 citrylCoA binding site [chemical binding]; other site 198628004207 NADH binding [chemical binding]; other site 198628004208 cationic pore residues; other site 198628004209 oxalacetate/citrate binding site [chemical binding]; other site 198628004210 coenzyme A binding site [chemical binding]; other site 198628004211 catalytic triad [active] 198628004212 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 198628004213 Iron-sulfur protein interface; other site 198628004214 proximal quinone binding site [chemical binding]; other site 198628004215 SdhD (CybS) interface [polypeptide binding]; other site 198628004216 proximal heme binding site [chemical binding]; other site 198628004217 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 198628004218 SdhC subunit interface [polypeptide binding]; other site 198628004219 proximal heme binding site [chemical binding]; other site 198628004220 cardiolipin binding site; other site 198628004221 Iron-sulfur protein interface; other site 198628004222 proximal quinone binding site [chemical binding]; other site 198628004223 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958 198628004224 L-aspartate oxidase; Provisional; Region: PRK06175 198628004225 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 198628004226 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 198628004227 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 198628004228 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 198628004229 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 198628004230 TPP-binding site [chemical binding]; other site 198628004231 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 198628004232 dimer interface [polypeptide binding]; other site 198628004233 PYR/PP interface [polypeptide binding]; other site 198628004234 TPP binding site [chemical binding]; other site 198628004235 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 198628004236 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 198628004237 E3 interaction surface; other site 198628004238 lipoyl attachment site [posttranslational modification]; other site 198628004239 e3 binding domain; Region: E3_binding; pfam02817 198628004240 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 198628004241 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 198628004242 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 198628004243 CoA-ligase; Region: Ligase_CoA; pfam00549 198628004244 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 198628004245 CoA binding domain; Region: CoA_binding; smart00881 198628004246 CoA-ligase; Region: Ligase_CoA; pfam00549 198628004247 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 198628004248 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 198628004249 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 198628004250 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 198628004251 Membrane bound YbgT-like protein; Region: YbgT_YccB; pfam08173 198628004252 hypothetical protein; Provisional; Region: PRK10588 198628004253 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 198628004254 active site 198628004255 colicin uptake protein TolQ; Provisional; Region: PRK10801 198628004256 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 198628004257 colicin uptake protein TolR; Provisional; Region: PRK11024 198628004258 cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510 198628004259 TolA C-terminal; Region: TolA; pfam06519 198628004260 translocation protein TolB; Provisional; Region: tolB; PRK03629 198628004261 TolB amino-terminal domain; Region: TolB_N; pfam04052 198628004262 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 198628004263 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 198628004264 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 198628004265 peptidoglycan-associated outer membrane lipoprotein; Provisional; Region: PRK10802 198628004266 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 198628004267 ligand binding site [chemical binding]; other site 198628004268 tol-pal system protein YbgF; Provisional; Region: PRK10803 198628004269 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 198628004270 TPR motif; other site 198628004271 binding surface 198628004272 Protein of unknown function (DUF554); Region: DUF554; pfam04474 198628004273 quinolinate synthetase; Provisional; Region: PRK09375 198628004274 nicotinamide riboside transporter PnuC; Provisional; Region: PRK15397 198628004275 zinc transporter ZitB; Provisional; Region: PRK03557 198628004276 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 198628004277 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 198628004278 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 198628004279 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 198628004280 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 198628004281 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 198628004282 catalytic core [active] 198628004283 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 198628004284 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 198628004285 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 198628004286 HlyD family secretion protein; Region: HlyD_3; pfam13437 198628004287 Domain of unknown function (DUF2383); Region: DUF2383; cl17556 198628004288 Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604 198628004289 Outer membrane efflux protein; Region: OEP; pfam02321 198628004290 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 198628004291 Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604 198628004292 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 198628004293 active site 198628004294 catalytic residues [active] 198628004295 galactokinase; Provisional; Region: PRK05101 198628004296 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 198628004297 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 198628004298 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720 198628004299 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 198628004300 dimer interface [polypeptide binding]; other site 198628004301 active site 198628004302 UDP-galactose-4-epimerase; Provisional; Region: PRK10675 198628004303 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 198628004304 NAD binding site [chemical binding]; other site 198628004305 homodimer interface [polypeptide binding]; other site 198628004306 active site 198628004307 substrate binding site [chemical binding]; other site 198628004308 putative molybdenum transport ATP-binding protein ModF; Provisional; Region: PRK10938 198628004309 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 198628004310 Walker A/P-loop; other site 198628004311 ATP binding site [chemical binding]; other site 198628004312 Q-loop/lid; other site 198628004313 ABC transporter signature motif; other site 198628004314 Walker B; other site 198628004315 D-loop; other site 198628004316 H-loop/switch region; other site 198628004317 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 198628004318 Walker A/P-loop; other site 198628004319 ATP binding site [chemical binding]; other site 198628004320 Q-loop/lid; other site 198628004321 ABC transporter signature motif; other site 198628004322 Walker B; other site 198628004323 D-loop; other site 198628004324 H-loop/switch region; other site 198628004325 DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676 198628004326 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 198628004327 molybdenum-pterin binding domain; Region: Mop; TIGR00638 198628004328 Protein of unknown function (DUF2592); Region: DUF2592; pfam10766 198628004329 molybdate transporter periplasmic protein; Provisional; Region: modA; PRK10677 198628004330 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 198628004331 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198628004332 dimer interface [polypeptide binding]; other site 198628004333 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 198628004334 conserved gate region; other site 198628004335 putative PBP binding loops; other site 198628004336 ABC-ATPase subunit interface; other site 198628004337 molybdate transporter ATP-binding protein; Provisional; Region: modC; PRK11144 198628004338 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 198628004339 Walker A/P-loop; other site 198628004340 ATP binding site [chemical binding]; other site 198628004341 Q-loop/lid; other site 198628004342 ABC transporter signature motif; other site 198628004343 Walker B; other site 198628004344 D-loop; other site 198628004345 H-loop/switch region; other site 198628004346 TOBE domain; Region: TOBE; cl01440 198628004347 pyridoxal phosphate (PLP) phosphatase; Provisional; Region: PRK10530 198628004348 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 198628004349 active site 198628004350 motif I; other site 198628004351 motif II; other site 198628004352 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 198628004353 6-phosphogluconolactonase; Provisional; Region: PRK11028 198628004354 Uncharacterized conserved protein [Function unknown]; Region: COG5276 198628004355 Methylthioribose-binding protein-like of ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_methylthioribose_binding_like; cd06305 198628004356 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 198628004357 putative ligand binding site [chemical binding]; other site 198628004358 VirK protein; Region: VirK; pfam06903 198628004359 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 198628004360 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 198628004361 active site 198628004362 HIGH motif; other site 198628004363 KMSKS motif; other site 198628004364 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 198628004365 tRNA binding surface [nucleotide binding]; other site 198628004366 anticodon binding site; other site 198628004367 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 198628004368 dimer interface [polypeptide binding]; other site 198628004369 putative tRNA-binding site [nucleotide binding]; other site 198628004370 antiporter inner membrane protein; Provisional; Region: PRK11670 198628004371 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 198628004372 Walker A motif; other site 198628004373 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 198628004374 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 198628004375 ATP-binding site [chemical binding]; other site 198628004376 Sugar specificity; other site 198628004377 Pyrimidine base specificity; other site 198628004378 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 198628004379 trimer interface [polypeptide binding]; other site 198628004380 active site 198628004381 putative assembly protein; Provisional; Region: PRK10833 198628004382 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 198628004383 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 198628004384 FOG: CBS domain [General function prediction only]; Region: COG0517 198628004385 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 198628004386 Transporter associated domain; Region: CorC_HlyC; smart01091 198628004387 polysaccharide export protein Wza; Provisional; Region: PRK15078 198628004388 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 198628004389 SLBB domain; Region: SLBB; pfam10531 198628004390 Low molecular weight phosphatase family; Region: LMWPc; cd00115 198628004391 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 198628004392 active site 198628004393 tyrosine kinase; Provisional; Region: PRK11519 198628004394 Chain length determinant protein; Region: Wzz; pfam02706 198628004395 Chain length determinant protein; Region: Wzz; cl15801 198628004396 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 198628004397 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 198628004398 undecaprenyl-phosphate galactose phosphotransferase; Provisional; Region: PRK15204 198628004399 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 198628004400 Bacterial sugar transferase; Region: Bac_transf; pfam02397 198628004401 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 198628004402 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 198628004403 dTDP-glucose 4,6 dehydratase; Provisional; Region: PRK10084 198628004404 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 198628004405 NAD binding site [chemical binding]; other site 198628004406 substrate binding site [chemical binding]; other site 198628004407 homodimer interface [polypeptide binding]; other site 198628004408 active site 198628004409 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 198628004410 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 198628004411 substrate binding site; other site 198628004412 tetramer interface; other site 198628004413 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 198628004414 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 198628004415 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 198628004416 NADP binding site [chemical binding]; other site 198628004417 active site 198628004418 putative substrate binding site [chemical binding]; other site 198628004419 RfbF is a putative dTDP-rhamnosyl transferase; Region: GT2_RfbF_like; cd02526 198628004420 L-rhamnosyltransferase; Region: rhamnosyltran; TIGR01556 198628004421 Ligand binding site; other site 198628004422 Protein of unknown function (DUF616); Region: DUF616; pfam04765 198628004423 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 198628004424 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 198628004425 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 198628004426 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 198628004427 active site 198628004428 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 198628004429 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 198628004430 putative NAD(P) binding site [chemical binding]; other site 198628004431 active site 198628004432 putative substrate binding site [chemical binding]; other site 198628004433 UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057 198628004434 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 198628004435 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 198628004436 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 198628004437 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 198628004438 active site 198628004439 tetramer interface; other site 198628004440 DUF based on E. rectale Gene description (DUF3880); Region: DUF3880; pfam12996 198628004441 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 198628004442 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 198628004443 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 198628004444 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 198628004445 Protein of unknown function (DUF2886); Region: DUF2886; pfam11102 198628004446 Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251 198628004447 Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082 198628004448 diguanylate cyclase AdrA; Provisional; Region: adrA; PRK10245 198628004449 MASE2 domain; Region: MASE2; pfam05230 198628004450 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 198628004451 metal binding site [ion binding]; metal-binding site 198628004452 active site 198628004453 I-site; other site 198628004454 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 198628004455 DNA-binding site [nucleotide binding]; DNA binding site 198628004456 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 198628004457 DNA-binding site [nucleotide binding]; DNA binding site 198628004458 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 198628004459 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 198628004460 probable AcnD-accessory protein PrpF; Region: prpF; TIGR02334 198628004461 short chain dehydrogenase; Provisional; Region: PRK12937 198628004462 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 198628004463 NADP binding site [chemical binding]; other site 198628004464 homodimer interface [polypeptide binding]; other site 198628004465 active site 198628004466 substrate binding site [chemical binding]; other site 198628004467 Protein of unknown function (DUF535); Region: DUF535; pfam04393 198628004468 Protein of unknown function (DUF1471); Region: DUF1471; cl11507 198628004469 Putative heme degradation protein [Inorganic ion transport and metabolism]; Region: HemS; COG3720 198628004470 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 198628004471 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 198628004472 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 198628004473 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 198628004474 intersubunit interface [polypeptide binding]; other site 198628004475 FecCD transport family; Region: FecCD; pfam01032 198628004476 putative PBP binding regions; other site 198628004477 ABC-ATPase subunit interface; other site 198628004478 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 198628004479 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 198628004480 Walker A/P-loop; other site 198628004481 ATP binding site [chemical binding]; other site 198628004482 Q-loop/lid; other site 198628004483 ABC transporter signature motif; other site 198628004484 Walker B; other site 198628004485 D-loop; other site 198628004486 H-loop/switch region; other site 198628004487 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 198628004488 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 198628004489 N-terminal plug; other site 198628004490 ligand-binding site [chemical binding]; other site 198628004491 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 198628004492 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 198628004493 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 198628004494 dimerization interface [polypeptide binding]; other site 198628004495 DPS ferroxidase diiron center [ion binding]; other site 198628004496 ion pore; other site 198628004497 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 198628004498 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 198628004499 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 198628004500 LuxR family transcriptional regulatory, chaperone HchA-associated; Region: reg_near_HchA; TIGR03541 198628004501 Autoinducer binding domain; Region: Autoind_bind; pfam03472 198628004502 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 198628004503 DNA binding residues [nucleotide binding] 198628004504 dimerization interface [polypeptide binding]; other site 198628004505 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 198628004506 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198628004507 dimer interface [polypeptide binding]; other site 198628004508 conserved gate region; other site 198628004509 putative PBP binding loops; other site 198628004510 ABC-ATPase subunit interface; other site 198628004511 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 198628004512 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198628004513 dimer interface [polypeptide binding]; other site 198628004514 conserved gate region; other site 198628004515 putative PBP binding loops; other site 198628004516 ABC-ATPase subunit interface; other site 198628004517 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 198628004518 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 198628004519 Walker A/P-loop; other site 198628004520 ATP binding site [chemical binding]; other site 198628004521 Q-loop/lid; other site 198628004522 ABC transporter signature motif; other site 198628004523 Walker B; other site 198628004524 D-loop; other site 198628004525 H-loop/switch region; other site 198628004526 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 198628004527 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 198628004528 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 198628004529 Walker A/P-loop; other site 198628004530 ATP binding site [chemical binding]; other site 198628004531 Q-loop/lid; other site 198628004532 ABC transporter signature motif; other site 198628004533 Walker B; other site 198628004534 D-loop; other site 198628004535 H-loop/switch region; other site 198628004536 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 198628004537 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 198628004538 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 198628004539 AMP nucleosidase; Provisional; Region: PRK08292 198628004540 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 198628004541 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 198628004542 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 198628004543 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 198628004544 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 198628004545 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 198628004546 Uncharacterized conserved protein [Function unknown]; Region: COG4104 198628004547 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 198628004548 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 198628004549 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 198628004550 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 198628004551 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 198628004552 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 198628004553 Domain of unknown function (DUF4123); Region: DUF4123; pfam13503 198628004554 Domain of unknown function (DUF4123); Region: DUF4123; pfam13503 198628004555 RHS Repeat; Region: RHS_repeat; cl11982 198628004556 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 198628004557 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 198628004558 RHS Repeat; Region: RHS_repeat; cl11982 198628004559 RHS Repeat; Region: RHS_repeat; pfam05593 198628004560 RHS Repeat; Region: RHS_repeat; pfam05593 198628004561 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 198628004562 Toxin SymE, type I toxin-antitoxin system; Region: SymE_toxin; cl07446 198628004563 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 198628004564 RHS Repeat; Region: RHS_repeat; pfam05593 198628004565 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 198628004566 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 198628004567 RHS Repeat; Region: RHS_repeat; pfam05593 198628004568 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 198628004569 Toxin SymE, type I toxin-antitoxin system; Region: SymE_toxin; cl07446 198628004570 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 198628004571 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 198628004572 metal binding site [ion binding]; metal-binding site 198628004573 putative dimer interface [polypeptide binding]; other site 198628004574 Protein of unknown function (DUF770); Region: DUF770; pfam05591 198628004575 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517 198628004576 Protein of unknown function (DUF877); Region: DUF877; pfam05943 198628004577 type VI secretion system lysozyme-like protein; Region: VI_zyme; TIGR03357 198628004578 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 198628004579 type VI secretion protein, VC_A0110 family; Region: VI_chp_6; TIGR03359 198628004580 type VI secretion protein, VC_A0111 family; Region: VI_chp_1; TIGR03347 198628004581 type VI secretion system FHA domain protein; Region: VI_FHA; TIGR03354 198628004582 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062 198628004583 phosphopeptide binding site; other site 198628004584 type VI secretion lipoprotein, VC_A0113 family; Region: VI_chp_3; TIGR03352 198628004585 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3522 198628004586 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 198628004587 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850 198628004588 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 198628004589 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 198628004590 Walker A motif; other site 198628004591 ATP binding site [chemical binding]; other site 198628004592 Walker B motif; other site 198628004593 arginine finger; other site 198628004594 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 198628004595 Walker A motif; other site 198628004596 ATP binding site [chemical binding]; other site 198628004597 Walker B motif; other site 198628004598 arginine finger; other site 198628004599 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 198628004600 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 198628004601 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 198628004602 Walker A motif; other site 198628004603 ATP binding site [chemical binding]; other site 198628004604 Walker B motif; other site 198628004605 arginine finger; other site 198628004606 Protein of unknown function (DUF3121); Region: DUF3121; cl11879 198628004607 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 198628004608 type VI secretion-associated protein, VC_A0119 family; Region: VI_chp_7; TIGR03362 198628004609 type VI secretion protein IcmF; Region: VI_IcmF; TIGR03348 198628004610 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 198628004611 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 198628004612 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 198628004613 ImpA domain protein; Region: DUF3702; pfam12486 198628004614 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 198628004615 Sel1-like repeats; Region: SEL1; smart00671 198628004616 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 198628004617 DKNYY family; Region: DKNYY; pfam13644 198628004618 DKNYY family; Region: DKNYY; pfam13644 198628004619 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 198628004620 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 198628004621 homodimer interface [polypeptide binding]; other site 198628004622 substrate-cofactor binding pocket; other site 198628004623 pyridoxal 5'-phosphate binding site [chemical binding]; other site 198628004624 catalytic residue [active] 198628004625 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 198628004626 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 198628004627 active site 198628004628 Protein of unknown function (DUF1611); Region: DUF1611; pfam07755 198628004629 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 198628004630 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 198628004631 metal binding site [ion binding]; metal-binding site 198628004632 active site 198628004633 I-site; other site 198628004634 Iron permease FTR1 family; Region: FTR1; cl00475 198628004635 inactive ferrous ion transporter periplasmic protein EfeO; Provisional; Region: PRK10378 198628004636 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 198628004637 Imelysin; Region: Peptidase_M75; pfam09375 198628004638 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 198628004639 Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837 198628004640 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3813 198628004641 Protein of unknown function (DUF1272); Region: DUF1272; pfam06906 198628004642 proline/glycine betaine transporter; Provisional; Region: PRK10642 198628004643 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198628004644 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198628004645 Osmosensory transporter coiled coil; Region: Osmo_CC; pfam08946 198628004646 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 198628004647 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 198628004648 non-specific DNA binding site [nucleotide binding]; other site 198628004649 salt bridge; other site 198628004650 sequence-specific DNA binding site [nucleotide binding]; other site 198628004651 HipA N-terminal domain; Region: Couple_hipA; pfam13657 198628004652 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 198628004653 HipA-like N-terminal domain; Region: HipA_N; pfam07805 198628004654 HipA-like C-terminal domain; Region: HipA_C; pfam07804 198628004655 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 198628004656 periplasmic multidrug efflux lipoprotein precursor; Reviewed; Region: PRK09578 198628004657 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 198628004658 HlyD family secretion protein; Region: HlyD_3; pfam13437 198628004659 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 198628004660 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 198628004661 active site 198628004662 phosphorylation site [posttranslational modification] 198628004663 intermolecular recognition site; other site 198628004664 dimerization interface [polypeptide binding]; other site 198628004665 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 198628004666 DNA binding site [nucleotide binding] 198628004667 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 198628004668 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 198628004669 dimerization interface [polypeptide binding]; other site 198628004670 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 198628004671 dimer interface [polypeptide binding]; other site 198628004672 phosphorylation site [posttranslational modification] 198628004673 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 198628004674 ATP binding site [chemical binding]; other site 198628004675 Mg2+ binding site [ion binding]; other site 198628004676 G-X-G motif; other site 198628004677 Transcriptional regulator [Transcription]; Region: LysR; COG0583 198628004678 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 198628004679 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 198628004680 putative dimerization interface [polypeptide binding]; other site 198628004681 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 198628004682 dimer interface [polypeptide binding]; other site 198628004683 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 198628004684 metal binding site [ion binding]; metal-binding site 198628004685 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 198628004686 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 198628004687 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 198628004688 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 198628004689 Uncharacterized conserved protein [Function unknown]; Region: COG1556 198628004690 iron-sulfur cluster-binding protein; Region: TIGR00273 198628004691 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 198628004692 4Fe-4S binding domain; Region: Fer4_2; pfam12797 198628004693 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 198628004694 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 198628004695 Cysteine-rich domain; Region: CCG; pfam02754 198628004696 Cysteine-rich domain; Region: CCG; pfam02754 198628004697 cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705 198628004698 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 198628004699 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 198628004700 S-adenosylmethionine binding site [chemical binding]; other site 198628004701 Cupin domain; Region: Cupin_2; pfam07883 198628004702 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 198628004703 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 198628004704 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 198628004705 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 198628004706 Transposase; Region: DEDD_Tnp_IS110; pfam01548 198628004707 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 198628004708 hypothetical protein; Provisional; Region: PRK10711 198628004709 hypothetical protein; Provisional; Region: PRK01821 198628004710 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 198628004711 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 198628004712 active site 198628004713 phosphorylation site [posttranslational modification] 198628004714 intermolecular recognition site; other site 198628004715 dimerization interface [polypeptide binding]; other site 198628004716 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 198628004717 DNA binding residues [nucleotide binding] 198628004718 dimerization interface [polypeptide binding]; other site 198628004719 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 198628004720 dimer interface [polypeptide binding]; other site 198628004721 phosphorylation site [posttranslational modification] 198628004722 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 198628004723 ATP binding site [chemical binding]; other site 198628004724 Mg2+ binding site [ion binding]; other site 198628004725 G-X-G motif; other site 198628004726 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 198628004727 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 198628004728 Walker A/P-loop; other site 198628004729 ATP binding site [chemical binding]; other site 198628004730 Q-loop/lid; other site 198628004731 ABC transporter signature motif; other site 198628004732 Walker B; other site 198628004733 D-loop; other site 198628004734 H-loop/switch region; other site 198628004735 ABC nitrate/sulfonate/bicarbonate family transporter, ATPase subunit; Region: ABC_transp; pfam09821 198628004736 ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism]; Region: COG4986 198628004737 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198628004738 dimer interface [polypeptide binding]; other site 198628004739 conserved gate region; other site 198628004740 putative PBP binding loops; other site 198628004741 ABC-ATPase subunit interface; other site 198628004742 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198628004743 dimer interface [polypeptide binding]; other site 198628004744 conserved gate region; other site 198628004745 putative PBP binding loops; other site 198628004746 ABC-ATPase subunit interface; other site 198628004747 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 198628004748 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 198628004749 dimer interface [polypeptide binding]; other site 198628004750 active site 198628004751 heme binding site [chemical binding]; other site 198628004752 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 198628004753 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 198628004754 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 198628004755 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 198628004756 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 198628004757 S-adenosylmethionine binding site [chemical binding]; other site 198628004758 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 198628004759 The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489 198628004760 substrate binding site [chemical binding]; other site 198628004761 nickel ABC transporter, permease subunit NikB; Region: nickel_nikB; TIGR02789 198628004762 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198628004763 dimer interface [polypeptide binding]; other site 198628004764 conserved gate region; other site 198628004765 putative PBP binding loops; other site 198628004766 ABC-ATPase subunit interface; other site 198628004767 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 198628004768 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198628004769 dimer interface [polypeptide binding]; other site 198628004770 conserved gate region; other site 198628004771 putative PBP binding loops; other site 198628004772 ABC-ATPase subunit interface; other site 198628004773 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 198628004774 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 198628004775 Walker A/P-loop; other site 198628004776 ATP binding site [chemical binding]; other site 198628004777 Q-loop/lid; other site 198628004778 ABC transporter signature motif; other site 198628004779 Walker B; other site 198628004780 D-loop; other site 198628004781 H-loop/switch region; other site 198628004782 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 198628004783 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 198628004784 Walker A/P-loop; other site 198628004785 ATP binding site [chemical binding]; other site 198628004786 Q-loop/lid; other site 198628004787 ABC transporter signature motif; other site 198628004788 Walker B; other site 198628004789 D-loop; other site 198628004790 H-loop/switch region; other site 198628004791 MarR family; Region: MarR_2; cl17246 198628004792 Transcriptional regulators [Transcription]; Region: MarR; COG1846 198628004793 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 198628004794 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 198628004795 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 198628004796 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 198628004797 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198628004798 putative substrate translocation pore; other site 198628004799 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198628004800 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 198628004801 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 198628004802 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 198628004803 hypothetical protein; Provisional; Region: PRK11667 198628004804 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 198628004805 Domain of unknown function (DUF1971); Region: DUF1971; cl17717 198628004806 Domain of unknown function (DUF1869); Region: DUF1869; pfam08956 198628004807 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198628004808 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 198628004809 putative substrate translocation pore; other site 198628004810 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 198628004811 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 198628004812 Walker A/P-loop; other site 198628004813 ATP binding site [chemical binding]; other site 198628004814 Q-loop/lid; other site 198628004815 ABC transporter signature motif; other site 198628004816 Walker B; other site 198628004817 D-loop; other site 198628004818 H-loop/switch region; other site 198628004819 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 198628004820 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 198628004821 beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525 198628004822 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 198628004823 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 198628004824 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 198628004825 Beta galactosidase small chain; Region: Bgal_small_N; pfam02929 198628004826 lac repressor; Reviewed; Region: lacI; PRK09526 198628004827 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 198628004828 DNA binding site [nucleotide binding] 198628004829 domain linker motif; other site 198628004830 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 198628004831 ligand binding site [chemical binding]; other site 198628004832 dimerization interface (open form) [polypeptide binding]; other site 198628004833 dimerization interface (closed form) [polypeptide binding]; other site 198628004834 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 198628004835 aspartate racemase; Region: asp_race; TIGR00035 198628004836 cell density-dependent motility repressor; Provisional; Region: PRK10082 198628004837 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 198628004838 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 198628004839 dimerization interface [polypeptide binding]; other site 198628004840 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 198628004841 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 198628004842 formate hydrogenlyase transcriptional activator FhlA; Provisional; Region: PRK15429 198628004843 GAF domain; Region: GAF; pfam01590 198628004844 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 198628004845 Walker A motif; other site 198628004846 ATP binding site [chemical binding]; other site 198628004847 Walker B motif; other site 198628004848 arginine finger; other site 198628004849 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 198628004850 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 198628004851 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 198628004852 [4Fe-4S] binding site [ion binding]; other site 198628004853 molybdopterin cofactor binding site; other site 198628004854 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790 198628004855 molybdopterin cofactor binding site; other site 198628004856 formate dehydrogenase-H ferredoxin subunit; Provisional; Region: PRK10330 198628004857 4Fe-4S binding domain; Region: Fer4; cl02805 198628004858 Domain of unknown function (DUF4160); Region: DUF4160; pfam13711 198628004859 Predicted transcriptional regulator [Transcription]; Region: COG3636; cl17681 198628004860 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 198628004861 Endopeptidases belonging to membrane-bound hydrogen evolving hydrogenase group. In hydrogenase 3 from E coli, the maturation of the large subunit (HycE) requires the cleavage of a C-terminal peptide by the endopeptidase HycI, before the final formation...; Region: H2MP_MemB-H2evol; cd06067 198628004862 nickel binding site [ion binding]; other site 198628004863 formate hydrogenlyase maturation protein HycH; Provisional; Region: PRK15084 198628004864 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 198628004865 hydrogenase 4 subunit H; Validated; Region: PRK08222 198628004866 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 198628004867 Ni,Fe-hydrogenase III component G [Energy production and conversion]; Region: HycE; COG3262 198628004868 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 198628004869 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 198628004870 hydrogenase 4 subunit F; Validated; Region: PRK06458 198628004871 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 198628004872 hydrogenase 4 membrane subunit; Provisional; Region: hyfE; PRK11492 198628004873 hydrogenase 4 subunit D; Validated; Region: PRK06525 198628004874 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 198628004875 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 198628004876 NADH dehydrogenase; Region: NADHdh; cl00469 198628004877 hydrogenase 4 subunit B; Validated; Region: PRK06521 198628004878 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 198628004879 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 198628004880 4Fe-4S binding domain; Region: Fer4; pfam00037 198628004881 hydrogenase 2 accessory protein HypG; Provisional; Region: PRK10413 198628004882 transcriptional regulator CysB-like protein; Reviewed; Region: PRK12682 198628004883 The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413 198628004884 substrate binding site [chemical binding]; other site 198628004885 dimerization interface [polypeptide binding]; other site 198628004886 glutamate/aspartate:proton symporter; Provisional; Region: gltP; PRK11283 198628004887 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 198628004888 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 198628004889 putative active site [active] 198628004890 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 198628004891 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 198628004892 putative S-transferase; Provisional; Region: PRK11752 198628004893 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 198628004894 C-terminal domain interface [polypeptide binding]; other site 198628004895 GSH binding site (G-site) [chemical binding]; other site 198628004896 dimer interface [polypeptide binding]; other site 198628004897 C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292 198628004898 dimer interface [polypeptide binding]; other site 198628004899 N-terminal domain interface [polypeptide binding]; other site 198628004900 active site 198628004901 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 198628004902 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 198628004903 putative active site [active] 198628004904 metal binding site [ion binding]; metal-binding site 198628004905 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 198628004906 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198628004907 putative PBP binding loops; other site 198628004908 dimer interface [polypeptide binding]; other site 198628004909 ABC-ATPase subunit interface; other site 198628004910 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 198628004911 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 198628004912 Walker A/P-loop; other site 198628004913 ATP binding site [chemical binding]; other site 198628004914 Q-loop/lid; other site 198628004915 ABC transporter signature motif; other site 198628004916 Walker B; other site 198628004917 D-loop; other site 198628004918 H-loop/switch region; other site 198628004919 NMT1-like family; Region: NMT1_2; pfam13379 198628004920 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 198628004921 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 198628004922 D-cysteine desulfhydrase; Validated; Region: PRK03910 198628004923 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 198628004924 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 198628004925 catalytic residue [active] 198628004926 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 198628004927 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 198628004928 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK12489 198628004929 Transcriptional regulator [Transcription]; Region: PaiB; COG2808 198628004930 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 198628004931 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 198628004932 DNA-binding site [nucleotide binding]; DNA binding site 198628004933 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 198628004934 pyridoxal 5'-phosphate binding site [chemical binding]; other site 198628004935 homodimer interface [polypeptide binding]; other site 198628004936 catalytic residue [active] 198628004937 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 198628004938 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 198628004939 tetrameric interface [polypeptide binding]; other site 198628004940 NAD binding site [chemical binding]; other site 198628004941 catalytic residues [active] 198628004942 substrate binding site [chemical binding]; other site 198628004943 putrescine--2-oxoglutarate aminotransferase; Provisional; Region: PRK11522 198628004944 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 198628004945 inhibitor-cofactor binding pocket; inhibition site 198628004946 pyridoxal 5'-phosphate binding site [chemical binding]; other site 198628004947 catalytic residue [active] 198628004948 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 198628004949 Protein of unknown function (DUF3916); Region: DUF3916; pfam13079 198628004950 phosphonate metabolism transcriptional regulator PhnF; Provisional; Region: PRK10079 198628004951 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 198628004952 DNA-binding site [nucleotide binding]; DNA binding site 198628004953 UTRA domain; Region: UTRA; pfam07702 198628004954 Phosphonate metabolism protein PhnG; Region: PhnG; pfam06754 198628004955 carbon-phosphorus lyase complex subunit; Validated; Region: phnH; PRK10147 198628004956 Bacterial phosphonate metabolism protein (PhnI); Region: PhnI; pfam05861 198628004957 Phosphonate metabolism protein PhnJ; Region: PhnJ; pfam06007 198628004958 phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701 198628004959 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 198628004960 Walker A/P-loop; other site 198628004961 ATP binding site [chemical binding]; other site 198628004962 Q-loop/lid; other site 198628004963 ABC transporter signature motif; other site 198628004964 Walker B; other site 198628004965 D-loop; other site 198628004966 H-loop/switch region; other site 198628004967 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 198628004968 ABC-type phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PhnL; COG4778 198628004969 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 198628004970 Walker A/P-loop; other site 198628004971 ATP binding site [chemical binding]; other site 198628004972 Q-loop/lid; other site 198628004973 ABC transporter signature motif; other site 198628004974 Walker B; other site 198628004975 D-loop; other site 198628004976 H-loop/switch region; other site 198628004977 phosphonate metabolism protein PhnM; Provisional; Region: PRK15446 198628004978 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 198628004979 PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306 198628004980 active site 198628004981 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 198628004982 AAA domain; Region: AAA_18; pfam13238 198628004983 active site 198628004984 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 198628004985 putative hydrolase; Provisional; Region: PRK02113 198628004986 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 198628004987 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 198628004988 active site 198628004989 catalytic tetrad [active] 198628004990 Transcriptional regulator [Transcription]; Region: LysR; COG0583 198628004991 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 198628004992 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 198628004993 putative effector binding pocket; other site 198628004994 putative dimerization interface [polypeptide binding]; other site 198628004995 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 198628004996 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 198628004997 Walker A/P-loop; other site 198628004998 ATP binding site [chemical binding]; other site 198628004999 Q-loop/lid; other site 198628005000 ABC transporter signature motif; other site 198628005001 Walker B; other site 198628005002 D-loop; other site 198628005003 H-loop/switch region; other site 198628005004 phosphonate ABC transporter, periplasmic phosphonate binding protein; Region: PhnD; TIGR03431 198628005005 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 198628005006 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198628005007 dimer interface [polypeptide binding]; other site 198628005008 conserved gate region; other site 198628005009 putative PBP binding loops; other site 198628005010 ABC-ATPase subunit interface; other site 198628005011 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 198628005012 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 198628005013 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656 198628005014 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cd09637 198628005015 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-C; cd09689 198628005016 CRISPR/Cas system-associated protein Cas8c; Region: Cas8c_I-C; cd09757 198628005017 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-C; cd09752 198628005018 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 198628005019 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 198628005020 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 198628005021 diaminobutyrate--2-oxoglutarate aminotransferase; Provisional; Region: PRK06931 198628005022 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 198628005023 inhibitor-cofactor binding pocket; inhibition site 198628005024 pyridoxal 5'-phosphate binding site [chemical binding]; other site 198628005025 catalytic residue [active] 198628005026 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 198628005027 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 198628005028 N-terminal plug; other site 198628005029 ligand-binding site [chemical binding]; other site 198628005030 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 198628005031 IucA / IucC family; Region: IucA_IucC; pfam04183 198628005032 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 198628005033 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 198628005034 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme PvsE; Region: PLPDE_III_PvsE_like; cd06843 198628005035 dimer interface [polypeptide binding]; other site 198628005036 active site 198628005037 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 198628005038 catalytic residues [active] 198628005039 substrate binding site [chemical binding]; other site 198628005040 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 198628005041 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198628005042 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 198628005043 IucA / IucC family; Region: IucA_IucC; pfam04183 198628005044 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 198628005045 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 198628005046 IucA / IucC family; Region: IucA_IucC; pfam04183 198628005047 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 198628005048 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 198628005049 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 198628005050 siderophore binding site; other site 198628005051 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 198628005052 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 198628005053 ABC-ATPase subunit interface; other site 198628005054 dimer interface [polypeptide binding]; other site 198628005055 putative PBP binding regions; other site 198628005056 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 198628005057 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 198628005058 ABC-ATPase subunit interface; other site 198628005059 dimer interface [polypeptide binding]; other site 198628005060 putative PBP binding regions; other site 198628005061 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 198628005062 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 198628005063 Walker A/P-loop; other site 198628005064 ATP binding site [chemical binding]; other site 198628005065 Q-loop/lid; other site 198628005066 ABC transporter signature motif; other site 198628005067 Walker B; other site 198628005068 D-loop; other site 198628005069 H-loop/switch region; other site 198628005070 hypothetical protein; Validated; Region: PRK06201 198628005071 Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684 198628005072 Winged helix-turn helix; Region: HTH_29; pfam13551 198628005073 Homeodomain-like domain; Region: HTH_23; pfam13384 198628005074 Homeodomain-like domain; Region: HTH_32; pfam13565 198628005075 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 198628005076 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 198628005077 non-specific DNA binding site [nucleotide binding]; other site 198628005078 salt bridge; other site 198628005079 sequence-specific DNA binding site [nucleotide binding]; other site 198628005080 Cupin domain; Region: Cupin_2; pfam07883 198628005081 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 198628005082 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 198628005083 Coenzyme A binding pocket [chemical binding]; other site 198628005084 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 198628005085 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 198628005086 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 198628005087 active site 198628005088 putative acetyltransferase YhhY; Provisional; Region: PRK10140 198628005089 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 198628005090 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 198628005091 Coenzyme A binding pocket [chemical binding]; other site 198628005092 Integrase core domain; Region: rve_3; pfam13683 198628005093 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: HicB; COG4226 198628005094 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 198628005095 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 198628005096 Transcriptional regulator [Transcription]; Region: LysR; COG0583 198628005097 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 198628005098 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 198628005099 putative dimerization interface [polypeptide binding]; other site 198628005100 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2828 198628005101 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198628005102 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 198628005103 putative substrate translocation pore; other site 198628005104 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 198628005105 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 198628005106 Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053 198628005107 Citrate lyase ligase; Region: Citrate_lyase_ligase; cd02169 198628005108 putative active site [active] 198628005109 (T/H)XGH motif; other site 198628005110 citrate lyase subunit gamma; Provisional; Region: PRK13253 198628005111 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 198628005112 Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051 198628005113 aconitate hydratase pseudogene containing single nucleotide deletion, resulting in two open reading frames 198628005114 formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553 198628005115 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 198628005116 [4Fe-4S] binding site [ion binding]; other site 198628005117 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 198628005118 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 198628005119 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 198628005120 molybdopterin cofactor binding site; other site 198628005121 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 198628005122 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 198628005123 formate dehydrogenase-N subunit gamma; Provisional; Region: PRK10179 198628005124 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 198628005125 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 198628005126 Transposase; Region: DEDD_Tnp_IS110; pfam01548 198628005127 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 198628005128 Transcriptional regulators [Transcription]; Region: PurR; COG1609 198628005129 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 198628005130 DNA binding site [nucleotide binding] 198628005131 domain linker motif; other site 198628005132 Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271 198628005133 ligand binding site [chemical binding]; other site 198628005134 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 198628005135 Melibiase; Region: Melibiase; pfam02065 198628005136 galactoside permease; Reviewed; Region: lacY; PRK09528 198628005137 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198628005138 putative substrate translocation pore; other site 198628005139 C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cd02619 198628005140 active site 198628005141 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 198628005142 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 198628005143 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 198628005144 putative ligand binding site [chemical binding]; other site 198628005145 NAD binding site [chemical binding]; other site 198628005146 dimerization interface [polypeptide binding]; other site 198628005147 catalytic site [active] 198628005148 EVE domain; Region: EVE; cl00728 198628005149 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 198628005150 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 198628005151 metal binding site [ion binding]; metal-binding site 198628005152 active site 198628005153 I-site; other site 198628005154 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 198628005155 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198628005156 dimer interface [polypeptide binding]; other site 198628005157 conserved gate region; other site 198628005158 putative PBP binding loops; other site 198628005159 ABC-ATPase subunit interface; other site 198628005160 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198628005161 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 198628005162 dimer interface [polypeptide binding]; other site 198628005163 conserved gate region; other site 198628005164 putative PBP binding loops; other site 198628005165 ABC-ATPase subunit interface; other site 198628005166 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 198628005167 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 198628005168 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 198628005169 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 198628005170 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 198628005171 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 198628005172 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 198628005173 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 198628005174 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 198628005175 N-terminal plug; other site 198628005176 ligand-binding site [chemical binding]; other site 198628005177 Transcriptional regulator [Transcription]; Region: LysR; COG0583 198628005178 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 198628005179 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 198628005180 dimerization interface [polypeptide binding]; other site 198628005181 Uncharacterized protein conserved in bacteria (DUF2076); Region: DUF2076; pfam09849 198628005182 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 198628005183 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 198628005184 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 198628005185 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 198628005186 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 198628005187 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 198628005188 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 198628005189 Walker A/P-loop; other site 198628005190 ATP binding site [chemical binding]; other site 198628005191 Q-loop/lid; other site 198628005192 ABC transporter signature motif; other site 198628005193 Walker B; other site 198628005194 D-loop; other site 198628005195 H-loop/switch region; other site 198628005196 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198628005197 dimer interface [polypeptide binding]; other site 198628005198 conserved gate region; other site 198628005199 ABC-ATPase subunit interface; other site 198628005200 Arylsulfotransferase (ASST); Region: Arylsulfotran_2; pfam14269 198628005201 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 198628005202 catalytic residues [active] 198628005203 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 198628005204 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 198628005205 Walker A/P-loop; other site 198628005206 ATP binding site [chemical binding]; other site 198628005207 Q-loop/lid; other site 198628005208 ABC transporter signature motif; other site 198628005209 Walker B; other site 198628005210 D-loop; other site 198628005211 H-loop/switch region; other site 198628005212 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 198628005213 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 198628005214 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 198628005215 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198628005216 dimer interface [polypeptide binding]; other site 198628005217 conserved gate region; other site 198628005218 putative PBP binding loops; other site 198628005219 ABC-ATPase subunit interface; other site 198628005220 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 198628005221 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 198628005222 Transcriptional regulator [Transcription]; Region: LysR; COG0583 198628005223 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 198628005224 LysR substrate binding domain; Region: LysR_substrate; pfam03466 198628005225 dimerization interface [polypeptide binding]; other site 198628005226 CDP-diacylglycerol pyrophosphatase; Provisional; Region: PRK05471 198628005227 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 198628005228 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 198628005229 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 198628005230 dimerization interface [polypeptide binding]; other site 198628005231 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 198628005232 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498 198628005233 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 198628005234 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 198628005235 inhibitor site; inhibition site 198628005236 active site 198628005237 dimer interface [polypeptide binding]; other site 198628005238 catalytic residue [active] 198628005239 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 198628005240 active site 198628005241 tetramer interface [polypeptide binding]; other site 198628005242 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 198628005243 active site 198628005244 tetramer interface [polypeptide binding]; other site 198628005245 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 198628005246 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198628005247 dimer interface [polypeptide binding]; other site 198628005248 conserved gate region; other site 198628005249 putative PBP binding loops; other site 198628005250 ABC-ATPase subunit interface; other site 198628005251 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 198628005252 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 198628005253 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198628005254 dimer interface [polypeptide binding]; other site 198628005255 conserved gate region; other site 198628005256 putative PBP binding loops; other site 198628005257 ABC-ATPase subunit interface; other site 198628005258 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 198628005259 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 198628005260 Walker A/P-loop; other site 198628005261 ATP binding site [chemical binding]; other site 198628005262 Q-loop/lid; other site 198628005263 ABC transporter signature motif; other site 198628005264 Walker B; other site 198628005265 D-loop; other site 198628005266 H-loop/switch region; other site 198628005267 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 198628005268 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 198628005269 Walker A/P-loop; other site 198628005270 ATP binding site [chemical binding]; other site 198628005271 Q-loop/lid; other site 198628005272 ABC transporter signature motif; other site 198628005273 Walker B; other site 198628005274 D-loop; other site 198628005275 H-loop/switch region; other site 198628005276 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 198628005277 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 198628005278 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 198628005279 Alginate lyase; Region: Alginate_lyase; pfam05426 198628005280 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 198628005281 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 198628005282 tetramer interface [polypeptide binding]; other site 198628005283 pyridoxal 5'-phosphate binding site [chemical binding]; other site 198628005284 catalytic residue [active] 198628005285 YheO-like PAS domain; Region: PAS_6; pfam08348 198628005286 HTH domain; Region: HTH_22; pfam13309 198628005287 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198628005288 Major Facilitator Superfamily; Region: MFS_1; pfam07690 198628005289 putative substrate translocation pore; other site 198628005290 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 198628005291 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 198628005292 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 198628005293 active site 198628005294 phosphorylation site [posttranslational modification] 198628005295 intermolecular recognition site; other site 198628005296 dimerization interface [polypeptide binding]; other site 198628005297 malonate decarboxylase, alpha subunit; Region: mdcA; TIGR01110 198628005298 Coenzyme A transferase; Region: CoA_trans; cl17247 198628005299 ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; cl00768 198628005300 Malonate decarboxylase delta subunit (MdcD); Region: ACP; cl06082 198628005301 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189 198628005302 Malonate decarboxylase gamma subunit (MdcE); Region: MdcE; pfam06833 198628005303 Membrane transport protein; Region: Mem_trans; cl09117 198628005304 phosphoribosyl-dephospho-CoA transferase; Provisional; Region: PRK01293 198628005305 Phosphoribosyl-dephospho-CoA transferase MdcG; Region: MdcG; pfam10620 198628005306 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 198628005307 malonate decarboxylase, epsilon subunit; Region: malonate_mdcH; TIGR03131 198628005308 Transcriptional regulator [Transcription]; Region: LysR; COG0583 198628005309 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 198628005310 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 198628005311 dimerization interface [polypeptide binding]; other site 198628005312 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 198628005313 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 198628005314 ABC-ATPase subunit interface; other site 198628005315 dimer interface [polypeptide binding]; other site 198628005316 putative PBP binding regions; other site 198628005317 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 198628005318 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 198628005319 ABC-ATPase subunit interface; other site 198628005320 dimer interface [polypeptide binding]; other site 198628005321 putative PBP binding regions; other site 198628005322 manganese/iron transporter ATP-binding protein; Provisional; Region: PRK15056 198628005323 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 198628005324 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 198628005325 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 198628005326 metal binding site [ion binding]; metal-binding site 198628005327 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 198628005328 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 198628005329 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 198628005330 dimerization interface [polypeptide binding]; other site 198628005331 substrate binding pocket [chemical binding]; other site 198628005332 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198628005333 D-galactonate transporter; Region: 2A0114; TIGR00893 198628005334 putative substrate translocation pore; other site 198628005335 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198628005336 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 198628005337 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 198628005338 NAD(P) binding site [chemical binding]; other site 198628005339 active site 198628005340 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 198628005341 TPP-binding site [chemical binding]; other site 198628005342 dimer interface [polypeptide binding]; other site 198628005343 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 198628005344 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 198628005345 PYR/PP interface [polypeptide binding]; other site 198628005346 dimer interface [polypeptide binding]; other site 198628005347 TPP binding site [chemical binding]; other site 198628005348 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 198628005349 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 198628005350 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 198628005351 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 198628005352 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 198628005353 dimer interface [polypeptide binding]; other site 198628005354 active site 198628005355 metal binding site [ion binding]; metal-binding site 198628005356 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 198628005357 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 198628005358 exopolyphosphatase; Region: exo_poly_only; TIGR03706 198628005359 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 198628005360 EamA-like transporter family; Region: EamA; pfam00892 198628005361 EamA-like transporter family; Region: EamA; pfam00892 198628005362 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 198628005363 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 198628005364 substrate binding pocket [chemical binding]; other site 198628005365 membrane-bound complex binding site; other site 198628005366 hinge residues; other site 198628005367 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 198628005368 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 198628005369 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 198628005370 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 198628005371 putative active site [active] 198628005372 aspartate aminotransferase; Provisional; Region: PRK05764 198628005373 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 198628005374 pyridoxal 5'-phosphate binding site [chemical binding]; other site 198628005375 homodimer interface [polypeptide binding]; other site 198628005376 catalytic residue [active] 198628005377 nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233 198628005378 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 198628005379 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 198628005380 putative dimerization interface [polypeptide binding]; other site 198628005381 acetyl-CoA carboxylase, biotin carboxyl carrier protein; Region: BCCP; TIGR00531 198628005382 Peptidase; Region: DUF3663; pfam12404 198628005383 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 198628005384 lipoyl-biotinyl attachment site [posttranslational modification]; other site 198628005385 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 198628005386 classical (c) SDRs; Region: SDR_c; cd05233 198628005387 NAD(P) binding site [chemical binding]; other site 198628005388 active site 198628005389 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198628005390 dimer interface [polypeptide binding]; other site 198628005391 conserved gate region; other site 198628005392 putative PBP binding loops; other site 198628005393 ABC-ATPase subunit interface; other site 198628005394 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198628005395 dimer interface [polypeptide binding]; other site 198628005396 conserved gate region; other site 198628005397 putative PBP binding loops; other site 198628005398 ABC-ATPase subunit interface; other site 198628005399 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 198628005400 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 198628005401 Walker A/P-loop; other site 198628005402 ATP binding site [chemical binding]; other site 198628005403 Q-loop/lid; other site 198628005404 ABC transporter signature motif; other site 198628005405 Walker B; other site 198628005406 D-loop; other site 198628005407 H-loop/switch region; other site 198628005408 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 198628005409 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 198628005410 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 198628005411 catalytic site [active] 198628005412 Domain of unknown function (DUF4189); Region: DUF4189; pfam13827 198628005413 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 198628005414 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; cl17626 198628005415 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 198628005416 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 198628005417 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 198628005418 conserved FAD binding motif [chemical binding]; other site 198628005419 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242 198628005420 putative dimer interface [polypeptide binding]; other site 198628005421 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 198628005422 ligand binding site [chemical binding]; other site 198628005423 Zn binding site [ion binding]; other site 198628005424 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 198628005425 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 198628005426 Conserved protein containing a Zn-ribbon-like motif, possibly RNA-binding [General function prediction only]; Region: COG5516 198628005427 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 198628005428 CGNR zinc finger; Region: zf-CGNR; pfam11706 198628005429 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 198628005430 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 198628005431 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3558 198628005432 SnoaL-like domain; Region: SnoaL_2; pfam12680 198628005433 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 198628005434 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 198628005435 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 198628005436 catalytic triad [active] 198628005437 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 198628005438 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 198628005439 cyanate hydratase; Validated; Region: PRK02866 198628005440 Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate. It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559 198628005441 oligomer interface [polypeptide binding]; other site 198628005442 active site 198628005443 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 198628005444 VirB8 protein; Region: VirB8; cl01500 198628005445 Type IV secretory pathway, VirB10 components [Intracellular trafficking and secretion]; Region: VirB10; COG2948 198628005446 Transposase; Region: HTH_Tnp_1; cl17663 198628005447 Condensation domain; Region: Condensation; pfam00668 198628005448 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 198628005449 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 198628005450 acyl-activating enzyme (AAE) consensus motif; other site 198628005451 AMP binding site [chemical binding]; other site 198628005452 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 198628005453 Condensation domain; Region: Condensation; pfam00668 198628005454 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 198628005455 The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116 198628005456 acyl-activating enzyme (AAE) consensus motif; other site 198628005457 AMP binding site [chemical binding]; other site 198628005458 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 198628005459 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 198628005460 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 198628005461 Bacterial conjugation TrbI-like protein; Region: TrbI; cl04242 198628005462 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 198628005463 High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I...; Region: HMG-box; cl00082 198628005464 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 198628005465 Homeodomain-like domain; Region: HTH_32; pfam13565 198628005466 Integrase core domain; Region: rve; pfam00665 198628005467 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 198628005468 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 198628005469 FeS/SAM binding site; other site 198628005470 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 198628005471 Transposase; Region: DEDD_Tnp_IS110; pfam01548 198628005472 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198628005473 putative transposase OrfB; Reviewed; Region: PHA02517 198628005474 HTH-like domain; Region: HTH_21; pfam13276 198628005475 Integrase core domain; Region: rve; pfam00665 198628005476 Integrase core domain; Region: rve_2; pfam13333 198628005477 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 198628005478 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 198628005479 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 198628005480 global DNA-binding transcriptional dual regulator H-NS; Provisional; Region: PRK10947 198628005481 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 198628005482 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 198628005483 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 198628005484 non-specific DNA binding site [nucleotide binding]; other site 198628005485 salt bridge; other site 198628005486 sequence-specific DNA binding site [nucleotide binding]; other site 198628005487 putative transposase OrfB; Reviewed; Region: PHA02517 198628005488 HTH-like domain; Region: HTH_21; pfam13276 198628005489 Integrase core domain; Region: rve; pfam00665 198628005490 Integrase core domain; Region: rve_3; pfam13683 198628005491 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198628005492 Transposase; Region: HTH_Tnp_1; pfam01527 198628005493 Transposase, Mutator family; Region: Transposase_mut; pfam00872 198628005494 Protein of unknown function (DUF796); Region: DUF796; cl01226 198628005495 DgsA anti-repressor MtfA; Provisional; Region: PRK15410 198628005496 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 198628005497 sugar binding site [chemical binding]; other site 198628005498 Proteolipid membrane potential modulator; Region: Pmp3; cl00431 198628005499 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 198628005500 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 198628005501 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 198628005502 putative metal binding site; other site 198628005503 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 198628005504 binding surface 198628005505 TPR motif; other site 198628005506 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 198628005507 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 198628005508 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 198628005509 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 198628005510 ATP binding site [chemical binding]; other site 198628005511 substrate interface [chemical binding]; other site 198628005512 molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK10680 198628005513 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 198628005514 dimer interface [polypeptide binding]; other site 198628005515 putative functional site; other site 198628005516 putative MPT binding site; other site 198628005517 malate dehydrogenase; Provisional; Region: PRK13529 198628005518 Malic enzyme, N-terminal domain; Region: malic; pfam00390 198628005519 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 198628005520 NAD(P) binding site [chemical binding]; other site 198628005521 cytidine deaminase; Provisional; Region: PRK09027 198628005522 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 198628005523 active site 198628005524 catalytic motif [active] 198628005525 Zn binding site [ion binding]; other site 198628005526 Cytidine and deoxycytidylate deaminase zinc-binding region; Region: dCMP_cyt_deam_2; pfam08211 198628005527 hypothetical protein; Provisional; Region: PRK10711 198628005528 hypothetical protein; Provisional; Region: PRK01821 198628005529 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 198628005530 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 198628005531 adenosylmethionine--8-amino-7-oxononanoate transaminase; Validated; Region: PRK07986 198628005532 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 198628005533 inhibitor-cofactor binding pocket; inhibition site 198628005534 pyridoxal 5'-phosphate binding site [chemical binding]; other site 198628005535 catalytic residue [active] 198628005536 biotin synthase; Provisional; Region: PRK15108 198628005537 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 198628005538 FeS/SAM binding site; other site 198628005539 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 198628005540 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 198628005541 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 198628005542 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 198628005543 catalytic residue [active] 198628005544 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 198628005545 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 198628005546 S-adenosylmethionine binding site [chemical binding]; other site 198628005547 AAA domain; Region: AAA_26; pfam13500 198628005548 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 198628005549 Dethiobiotin synthetase (DTBS) is the penultimate enzyme in the biotin biosynthesis pathway in Escherichia coli and other microorganisms. The enzyme catalyzes formation of the ureido ring of dethiobiotin from (7R,8S)-7,8-diaminononanoic acid (DAPA) and...; Region: DTBS; cd03109 198628005550 excinuclease ABC subunit B; Provisional; Region: PRK05298 198628005551 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 198628005552 ATP binding site [chemical binding]; other site 198628005553 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 198628005554 nucleotide binding region [chemical binding]; other site 198628005555 ATP-binding site [chemical binding]; other site 198628005556 Ultra-violet resistance protein B; Region: UvrB; pfam12344 198628005557 UvrB/uvrC motif; Region: UVR; pfam02151 198628005558 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 198628005559 active site 198628005560 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 198628005561 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 198628005562 phosphate binding site [ion binding]; other site 198628005563 putative substrate binding pocket [chemical binding]; other site 198628005564 dimer interface [polypeptide binding]; other site 198628005565 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 198628005566 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 198628005567 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 198628005568 Protein of unknown function (DUF2474); Region: DUF2474; pfam10617 198628005569 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 198628005570 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 198628005571 FeS/SAM binding site; other site 198628005572 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 198628005573 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 198628005574 MPT binding site; other site 198628005575 trimer interface [polypeptide binding]; other site 198628005576 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 198628005577 trimer interface [polypeptide binding]; other site 198628005578 dimer interface [polypeptide binding]; other site 198628005579 putative active site [active] 198628005580 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 198628005581 MoaE interaction surface [polypeptide binding]; other site 198628005582 MoeB interaction surface [polypeptide binding]; other site 198628005583 thiocarboxylated glycine; other site 198628005584 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 198628005585 MoaE homodimer interface [polypeptide binding]; other site 198628005586 MoaD interaction [polypeptide binding]; other site 198628005587 active site residues [active] 198628005588 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 198628005589 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 198628005590 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 198628005591 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198628005592 dimer interface [polypeptide binding]; other site 198628005593 conserved gate region; other site 198628005594 putative PBP binding loops; other site 198628005595 ABC-ATPase subunit interface; other site 198628005596 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198628005597 dimer interface [polypeptide binding]; other site 198628005598 conserved gate region; other site 198628005599 putative PBP binding loops; other site 198628005600 ABC-ATPase subunit interface; other site 198628005601 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 198628005602 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 198628005603 Walker A/P-loop; other site 198628005604 ATP binding site [chemical binding]; other site 198628005605 Q-loop/lid; other site 198628005606 ABC transporter signature motif; other site 198628005607 Walker B; other site 198628005608 D-loop; other site 198628005609 H-loop/switch region; other site 198628005610 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 198628005611 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 198628005612 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 198628005613 Transposase; Region: DEDD_Tnp_IS110; pfam01548 198628005614 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 198628005615 cardiolipin synthase 2; Provisional; Region: PRK11263 198628005616 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 198628005617 putative active site [active] 198628005618 catalytic site [active] 198628005619 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 198628005620 putative active site [active] 198628005621 catalytic site [active] 198628005622 Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568 198628005623 putative catalytic site [active] 198628005624 putative metal binding site [ion binding]; other site 198628005625 putative phosphate binding site [ion binding]; other site 198628005626 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 198628005627 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 198628005628 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 198628005629 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 198628005630 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 198628005631 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 198628005632 Walker A/P-loop; other site 198628005633 ATP binding site [chemical binding]; other site 198628005634 Q-loop/lid; other site 198628005635 ABC transporter signature motif; other site 198628005636 Walker B; other site 198628005637 D-loop; other site 198628005638 H-loop/switch region; other site 198628005639 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 198628005640 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 198628005641 Walker A/P-loop; other site 198628005642 ATP binding site [chemical binding]; other site 198628005643 Q-loop/lid; other site 198628005644 ABC transporter signature motif; other site 198628005645 Walker B; other site 198628005646 D-loop; other site 198628005647 H-loop/switch region; other site 198628005648 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 198628005649 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 198628005650 HlyD family secretion protein; Region: HlyD_3; pfam13437 198628005651 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 198628005652 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 198628005653 ATP binding site [chemical binding]; other site 198628005654 Mg++ binding site [ion binding]; other site 198628005655 motif III; other site 198628005656 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 198628005657 nucleotide binding region [chemical binding]; other site 198628005658 ATP-binding site [chemical binding]; other site 198628005659 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 198628005660 EamA-like transporter family; Region: EamA; pfam00892 198628005661 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 198628005662 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 198628005663 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 198628005664 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_10; cd08515 198628005665 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 198628005666 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 198628005667 Walker A/P-loop; other site 198628005668 ATP binding site [chemical binding]; other site 198628005669 Q-loop/lid; other site 198628005670 ABC transporter signature motif; other site 198628005671 Walker B; other site 198628005672 D-loop; other site 198628005673 H-loop/switch region; other site 198628005674 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 198628005675 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 198628005676 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 198628005677 Walker A/P-loop; other site 198628005678 ATP binding site [chemical binding]; other site 198628005679 Q-loop/lid; other site 198628005680 ABC transporter signature motif; other site 198628005681 Walker B; other site 198628005682 D-loop; other site 198628005683 H-loop/switch region; other site 198628005684 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 198628005685 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 198628005686 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198628005687 dimer interface [polypeptide binding]; other site 198628005688 conserved gate region; other site 198628005689 putative PBP binding loops; other site 198628005690 ABC-ATPase subunit interface; other site 198628005691 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 198628005692 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198628005693 dimer interface [polypeptide binding]; other site 198628005694 conserved gate region; other site 198628005695 ABC-ATPase subunit interface; other site 198628005696 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 198628005697 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 198628005698 active site 198628005699 catalytic site [active] 198628005700 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 198628005701 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 198628005702 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 198628005703 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 198628005704 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 198628005705 Di- and tripeptidases [Amino acid transport and metabolism]; Region: PepD; COG2195 198628005706 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 198628005707 metal binding site [ion binding]; metal-binding site 198628005708 dimer interface [polypeptide binding]; other site 198628005709 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 198628005710 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 198628005711 peptide binding site [polypeptide binding]; other site 198628005712 tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550 198628005713 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 198628005714 FMN binding site [chemical binding]; other site 198628005715 active site 198628005716 catalytic residues [active] 198628005717 substrate binding site [chemical binding]; other site 198628005718 Adenylyl cyclase (AC) class IV-like, a subgroup of the CYTH-like superfamily; Region: CYTH-like_AC_IV-like; cd07890 198628005719 putative active site [active] 198628005720 putative metal binding residues [ion binding]; other site 198628005721 signature motif; other site 198628005722 putative triphosphate binding site [ion binding]; other site 198628005723 dimer interface [polypeptide binding]; other site 198628005724 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1636 198628005725 D-alanyl-D-alanine endopeptidase; Provisional; Region: pbpG; PRK11669 198628005726 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 198628005727 GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043 198628005728 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 198628005729 putative C-terminal domain interface [polypeptide binding]; other site 198628005730 putative GSH binding site (G-site) [chemical binding]; other site 198628005731 putative dimer interface [polypeptide binding]; other site 198628005732 C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194 198628005733 putative substrate binding pocket (H-site) [chemical binding]; other site 198628005734 putative N-terminal domain interface [polypeptide binding]; other site 198628005735 transcriptional repressor UlaR; Provisional; Region: PRK13509 198628005736 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 198628005737 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 198628005738 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 198628005739 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 198628005740 inhibitor-cofactor binding pocket; inhibition site 198628005741 pyridoxal 5'-phosphate binding site [chemical binding]; other site 198628005742 catalytic residue [active] 198628005743 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 198628005744 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 198628005745 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 198628005746 ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747 198628005747 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 198628005748 DEAD_2; Region: DEAD_2; pfam06733 198628005749 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 198628005750 TPR repeat; Region: TPR_11; pfam13414 198628005751 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 198628005752 binding surface 198628005753 TPR motif; other site 198628005754 Tetratricopeptide repeat; Region: TPR_12; pfam13424 198628005755 glycosyl transferase family protein; Provisional; Region: PRK08136 198628005756 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 198628005757 Peptidase M3-like family, a zincin metallopeptidase, includes M3 and M32 families; Region: M3_like; cd06258 198628005758 active site 198628005759 Zn binding site [ion binding]; other site 198628005760 PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397 198628005761 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 198628005762 active site 198628005763 PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397 198628005764 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 198628005765 active site 198628005766 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 198628005767 Interdomain contacts; other site 198628005768 Cytokine receptor motif; other site 198628005769 Protein of unknown function (DUF1349); Region: DUF1349; cl01397 198628005770 glutamine ABC transporter ATP-binding protein; Reviewed; Region: glnQ; PRK09493 198628005771 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 198628005772 Walker A/P-loop; other site 198628005773 ATP binding site [chemical binding]; other site 198628005774 Q-loop/lid; other site 198628005775 ABC transporter signature motif; other site 198628005776 Walker B; other site 198628005777 D-loop; other site 198628005778 H-loop/switch region; other site 198628005779 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 198628005780 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198628005781 dimer interface [polypeptide binding]; other site 198628005782 conserved gate region; other site 198628005783 putative PBP binding loops; other site 198628005784 ABC-ATPase subunit interface; other site 198628005785 glutamine ABC transporter periplasmic protein; Reviewed; Region: glnH; PRK09495 198628005786 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 198628005787 substrate binding pocket [chemical binding]; other site 198628005788 membrane-bound complex binding site; other site 198628005789 hinge residues; other site 198628005790 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 198628005791 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 198628005792 dimerization interface [polypeptide binding]; other site 198628005793 DPS ferroxidase diiron center [ion binding]; other site 198628005794 ion pore; other site 198628005795 threonine and homoserine efflux system; Provisional; Region: PRK10532 198628005796 EamA-like transporter family; Region: EamA; pfam00892 198628005797 outer membrane protein X; Provisional; Region: ompX; PRK09408 198628005798 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 198628005799 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 198628005800 MarR family; Region: MarR_2; cl17246 198628005801 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 198628005802 putative cyanate transporter; Provisional; Region: cynX; PRK09705 198628005803 Transcriptional regulator [Transcription]; Region: LysR; COG0583 198628005804 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 198628005805 The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412 198628005806 putative substrate binding pocket [chemical binding]; other site 198628005807 dimerization interface [polypeptide binding]; other site 198628005808 uncharacterized proteins similar to the Aspergillus nidulans lactam utilization protein LamB; Region: LamB_YcsF_like_2; cd11664 198628005809 putative active site [active] 198628005810 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 198628005811 carboxyltransferase (CT) interaction site; other site 198628005812 biotinylation site [posttranslational modification]; other site 198628005813 acetyl-CoA carboxylase biotin carboxylase subunit; Provisional; Region: PRK12833 198628005814 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 198628005815 ATP-grasp domain; Region: ATP-grasp_4; cl17255 198628005816 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 198628005817 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 198628005818 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 198628005819 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 198628005821 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 198628005822 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 198628005823 putative dimer interface [polypeptide binding]; other site 198628005824 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 198628005825 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 198628005826 Walker A/P-loop; other site 198628005827 ATP binding site [chemical binding]; other site 198628005828 Q-loop/lid; other site 198628005829 ABC transporter signature motif; other site 198628005830 Walker B; other site 198628005831 D-loop; other site 198628005832 H-loop/switch region; other site 198628005833 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 198628005834 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 198628005835 Outer membrane efflux protein; Region: OEP; pfam02321 198628005836 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 198628005837 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 198628005838 HlyD family secretion protein; Region: HlyD_3; pfam13437 198628005839 acyl-CoA thioesterase; Provisional; Region: PRK10531 198628005840 putative pectinesterase; Region: PLN02432; cl01911 198628005841 GlpM protein; Region: GlpM; pfam06942 198628005842 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 198628005843 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 198628005844 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 198628005845 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198628005846 dimer interface [polypeptide binding]; other site 198628005847 conserved gate region; other site 198628005848 putative PBP binding loops; other site 198628005849 ABC-ATPase subunit interface; other site 198628005850 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 198628005851 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198628005852 putative PBP binding loops; other site 198628005853 dimer interface [polypeptide binding]; other site 198628005854 ABC-ATPase subunit interface; other site 198628005855 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 198628005856 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 198628005857 Walker A/P-loop; other site 198628005858 ATP binding site [chemical binding]; other site 198628005859 Q-loop/lid; other site 198628005860 ABC transporter signature motif; other site 198628005861 Walker B; other site 198628005862 D-loop; other site 198628005863 H-loop/switch region; other site 198628005864 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 198628005865 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 198628005866 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 198628005867 Walker A/P-loop; other site 198628005868 ATP binding site [chemical binding]; other site 198628005869 Q-loop/lid; other site 198628005870 ABC transporter signature motif; other site 198628005871 Walker B; other site 198628005872 D-loop; other site 198628005873 H-loop/switch region; other site 198628005874 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 198628005875 Predicted transcriptional regulators [Transcription]; Region: COG1733 198628005876 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 198628005877 Chagasin family peptidase inhibitor I42; Region: Inhibitor_I42; pfam09394 198628005878 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 198628005879 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 198628005880 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 198628005881 remnant of arsB lacking N-terminus and containing internal frameshift, resulting in two open reading frames, arsB_1 and arsB_2 198628005882 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 198628005883 ArsC family; Region: ArsC; pfam03960 198628005884 catalytic residues [active] 198628005885 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 198628005886 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 198628005887 C-terminal domain interface [polypeptide binding]; other site 198628005888 GSH binding site (G-site) [chemical binding]; other site 198628005889 dimer interface [polypeptide binding]; other site 198628005890 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 198628005891 N-terminal domain interface [polypeptide binding]; other site 198628005892 dimer interface [polypeptide binding]; other site 198628005893 substrate binding pocket (H-site) [chemical binding]; other site 198628005894 short chain dehydrogenase; Provisional; Region: PRK06500 198628005895 classical (c) SDRs; Region: SDR_c; cd05233 198628005896 NAD(P) binding site [chemical binding]; other site 198628005897 active site 198628005898 Transcriptional regulator [Transcription]; Region: LysR; COG0583 198628005899 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 198628005900 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 198628005901 putative effector binding pocket; other site 198628005902 dimerization interface [polypeptide binding]; other site 198628005903 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 198628005904 Domain of unknown function (DUF4224); Region: DUF4224; pfam13986 198628005905 Protein of unknown function (DUF1019); Region: DUF1019; pfam06254 198628005906 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 198628005907 HTH-like domain; Region: HTH_21; pfam13276 198628005908 Integrase core domain; Region: rve; pfam00665 198628005909 Integrase core domain; Region: rve_3; pfam13683 198628005910 Helix-turn-helix domain; Region: HTH_28; pfam13518 198628005911 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 198628005912 catalytic residue [active] 198628005913 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4643 198628005914 Zinc-binding domain of primase-helicase; Region: Prim_Zn_Ribbon; smart00778 198628005915 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 198628005916 active site 198628005917 metal binding site [ion binding]; metal-binding site 198628005918 interdomain interaction site; other site 198628005919 Superfamily II helicase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG5519 198628005920 Ash protein family; Region: Phage_ASH; pfam10554 198628005921 AntA/AntB antirepressor; Region: AntA; pfam08346 198628005922 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 198628005923 integrase; Provisional; Region: PRK09692 198628005924 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 198628005925 active site 198628005926 Int/Topo IB signature motif; other site 198628005927 Predicted hydrolase of alkaline phosphatase superfamily [General function prediction only]; Region: COG3083 198628005928 Domain of unknown function (DUF3413); Region: DUF3413; pfam11893 198628005929 Sulfatase; Region: Sulfatase; cl17466 198628005930 hypothetical protein; Provisional; Region: PRK13689 198628005931 Nucleoid-associated protein [General function prediction only]; Region: COG3081 198628005932 nucleoid-associated protein NdpA; Validated; Region: PRK00378 198628005933 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 198628005934 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 198628005935 Histidine kinase; Region: His_kinase; pfam06580 198628005936 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 198628005937 ATP binding site [chemical binding]; other site 198628005938 Mg2+ binding site [ion binding]; other site 198628005939 G-X-G motif; other site 198628005940 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 198628005941 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 198628005942 active site 198628005943 phosphorylation site [posttranslational modification] 198628005944 intermolecular recognition site; other site 198628005945 dimerization interface [polypeptide binding]; other site 198628005946 LytTr DNA-binding domain; Region: LytTR; pfam04397 198628005947 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 198628005948 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198628005949 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 198628005950 5S rRNA interface [nucleotide binding]; other site 198628005951 CTC domain interface [polypeptide binding]; other site 198628005952 L16 interface [polypeptide binding]; other site 198628005953 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 198628005954 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 198628005955 ATP binding site [chemical binding]; other site 198628005956 putative Mg++ binding site [ion binding]; other site 198628005957 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 198628005958 nucleotide binding region [chemical binding]; other site 198628005959 ATP-binding site [chemical binding]; other site 198628005960 probable metal-binding protein; Region: matur_matur; TIGR03853 198628005961 16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839 198628005962 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 198628005963 RNA binding surface [nucleotide binding]; other site 198628005964 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 198628005965 active site 198628005966 uracil binding [chemical binding]; other site 198628005967 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198628005968 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 198628005969 putative substrate translocation pore; other site 198628005970 hypothetical protein; Provisional; Region: PRK11835 198628005971 microcin C ABC transporter ATP-binding protein YejF; Provisional; Region: PRK15134 198628005972 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 198628005973 Walker A/P-loop; other site 198628005974 ATP binding site [chemical binding]; other site 198628005975 Q-loop/lid; other site 198628005976 ABC transporter signature motif; other site 198628005977 Walker B; other site 198628005978 D-loop; other site 198628005979 H-loop/switch region; other site 198628005980 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 198628005981 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 198628005982 Walker A/P-loop; other site 198628005983 ATP binding site [chemical binding]; other site 198628005984 Q-loop/lid; other site 198628005985 ABC transporter signature motif; other site 198628005986 Walker B; other site 198628005987 D-loop; other site 198628005988 H-loop/switch region; other site 198628005989 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 198628005990 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198628005991 dimer interface [polypeptide binding]; other site 198628005992 conserved gate region; other site 198628005993 putative PBP binding loops; other site 198628005994 ABC-ATPase subunit interface; other site 198628005995 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 198628005996 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198628005997 dimer interface [polypeptide binding]; other site 198628005998 conserved gate region; other site 198628005999 putative PBP binding loops; other site 198628006000 ABC-ATPase subunit interface; other site 198628006001 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 198628006002 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 198628006003 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 198628006004 outer membrane lipoprotein; Provisional; Region: spr; PRK10838 198628006005 NlpC/P60 family; Region: NLPC_P60; pfam00877 198628006006 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 198628006007 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 198628006008 active site 198628006009 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 198628006010 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 198628006011 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 198628006012 elongation factor P; Provisional; Region: PRK04542 198628006013 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 198628006014 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 198628006015 RNA binding site [nucleotide binding]; other site 198628006016 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 198628006017 RNA binding site [nucleotide binding]; other site 198628006018 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 198628006019 Transcriptional regulator [Transcription]; Region: IclR; COG1414 198628006020 Bacterial transcriptional regulator; Region: IclR; pfam01614 198628006021 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 198628006022 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664 198628006023 metal binding site [ion binding]; metal-binding site 198628006024 putative dimer interface [polypeptide binding]; other site 198628006025 sugar efflux transporter B; Provisional; Region: PRK15011 198628006026 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198628006027 putative substrate translocation pore; other site 198628006028 bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK11109 198628006029 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 198628006030 active site 198628006031 phosphorylation site [posttranslational modification] 198628006032 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 198628006033 dimerization domain swap beta strand [polypeptide binding]; other site 198628006034 regulatory protein interface [polypeptide binding]; other site 198628006035 active site 198628006036 regulatory phosphorylation site [posttranslational modification]; other site 198628006037 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 198628006038 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 198628006039 putative substrate binding site [chemical binding]; other site 198628006040 putative ATP binding site [chemical binding]; other site 198628006041 PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712 198628006042 N-terminal domain of the phosphotransferase system fructose-specific component IIB [Carbohydrate transport and metabolism]; Region: COG3925 198628006043 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 198628006044 active site 198628006045 P-loop; other site 198628006046 phosphorylation site [posttranslational modification] 198628006047 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425 198628006048 endonuclease IV; Provisional; Region: PRK01060 198628006049 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 198628006050 AP (apurinic/apyrimidinic) site pocket; other site 198628006051 DNA interaction; other site 198628006052 Metal-binding active site; metal-binding site 198628006053 Predicted membrane protein [Function unknown]; Region: COG2855 198628006054 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 198628006055 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 198628006056 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 198628006057 putative dimerization interface [polypeptide binding]; other site 198628006058 lysine transporter; Provisional; Region: PRK10836 198628006059 putative arabinose transporter; Provisional; Region: PRK03545 198628006060 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198628006061 putative substrate translocation pore; other site 198628006062 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK06816 198628006063 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 198628006064 active site 198628006065 Predicted enzyme involved in methoxymalonyl-ACP biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FkbH; COG3882 198628006066 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 198628006067 active site 198628006068 motif I; other site 198628006069 motif II; other site 198628006070 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 198628006071 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 198628006072 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes [Energy production and conversion]; Region: AceF; COG0508 198628006073 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 198628006074 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 198628006075 TM-ABC transporter signature motif; other site 198628006076 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 198628006077 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 198628006078 Walker A/P-loop; other site 198628006079 ATP binding site [chemical binding]; other site 198628006080 Q-loop/lid; other site 198628006081 ABC transporter signature motif; other site 198628006082 Walker B; other site 198628006083 D-loop; other site 198628006084 H-loop/switch region; other site 198628006085 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 198628006086 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 198628006087 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 198628006088 putative active site [active] 198628006089 metal binding site [ion binding]; metal-binding site 198628006090 KTSC domain; Region: KTSC; pfam13619 198628006091 S-formylglutathione hydrolase; Region: PLN02442 198628006092 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 198628006093 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 198628006094 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 198628006095 substrate binding site [chemical binding]; other site 198628006096 catalytic Zn binding site [ion binding]; other site 198628006097 NAD binding site [chemical binding]; other site 198628006098 structural Zn binding site [ion binding]; other site 198628006099 dimer interface [polypeptide binding]; other site 198628006100 Transcriptional regulator [Transcription]; Region: LysR; COG0583 198628006101 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 198628006102 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 198628006103 dimerization interface [polypeptide binding]; other site 198628006104 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 198628006105 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 198628006106 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 198628006107 dimer interface [polypeptide binding]; other site 198628006108 putative CheW interface [polypeptide binding]; other site 198628006109 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 198628006110 Transposase; Region: DEDD_Tnp_IS110; pfam01548 198628006111 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 198628006112 Transposase IS200 like; Region: Y1_Tnp; pfam01797 198628006113 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 198628006114 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 198628006115 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 198628006116 dimer interface [polypeptide binding]; other site 198628006117 putative CheW interface [polypeptide binding]; other site 198628006118 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 198628006119 dimer interface [polypeptide binding]; other site 198628006120 ligand binding site [chemical binding]; other site 198628006121 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 198628006122 dimer interface [polypeptide binding]; other site 198628006123 putative CheW interface [polypeptide binding]; other site 198628006124 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 198628006125 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 198628006126 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 198628006127 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 198628006128 dimer interface [polypeptide binding]; other site 198628006129 putative CheW interface [polypeptide binding]; other site 198628006130 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 198628006131 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 198628006132 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 198628006133 dimer interface [polypeptide binding]; other site 198628006134 putative CheW interface [polypeptide binding]; other site 198628006135 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 198628006136 active site 198628006137 Predicted membrane protein [Function unknown]; Region: COG2311 198628006138 hypothetical protein; Provisional; Region: PRK10835 198628006139 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 198628006140 putative active site [active] 198628006141 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 198628006142 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 198628006143 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 198628006144 FeS/SAM binding site; other site 198628006145 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 198628006146 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 198628006147 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 198628006148 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 198628006149 putative C-terminal domain interface [polypeptide binding]; other site 198628006150 putative GSH binding site (G-site) [chemical binding]; other site 198628006151 putative dimer interface [polypeptide binding]; other site 198628006152 C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180 198628006153 putative N-terminal domain interface [polypeptide binding]; other site 198628006154 putative dimer interface [polypeptide binding]; other site 198628006155 putative substrate binding pocket (H-site) [chemical binding]; other site 198628006156 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 198628006157 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 198628006158 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 198628006159 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 198628006160 Walker A/P-loop; other site 198628006161 ATP binding site [chemical binding]; other site 198628006162 Q-loop/lid; other site 198628006163 ABC transporter signature motif; other site 198628006164 Walker B; other site 198628006165 D-loop; other site 198628006166 H-loop/switch region; other site 198628006167 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 198628006168 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198628006169 dimer interface [polypeptide binding]; other site 198628006170 conserved gate region; other site 198628006171 ABC-ATPase subunit interface; other site 198628006172 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 198628006173 VirB8 protein; Region: VirB8; cl01500 198628006174 D-alanyl-D-alanine carboxypeptidase fraction C; Provisional; Region: PRK10001 198628006175 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 198628006176 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 198628006177 DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681 198628006178 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 198628006179 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 198628006180 putative transporter; Provisional; Region: PRK04972 198628006181 Predicted Permease Membrane Region; Region: Asp-Al_Ex; cl06061 198628006182 TrkA-C domain; Region: TrkA_C; pfam02080 198628006183 TrkA-C domain; Region: TrkA_C; pfam02080 198628006184 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 198628006185 Putative inner membrane protein of Enterobacteriaceae; Region: YbjM; pfam11045 198628006186 Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066 198628006187 GSH binding site [chemical binding]; other site 198628006188 catalytic residues [active] 198628006189 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 198628006190 dimer interface [polypeptide binding]; other site 198628006191 FMN binding site [chemical binding]; other site 198628006192 NADPH bind site [chemical binding]; other site 198628006193 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 198628006194 RimK-like ATP-grasp domain; Region: RimK; pfam08443 198628006195 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 198628006196 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 198628006197 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 198628006198 putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607 198628006199 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 198628006200 Walker A/P-loop; other site 198628006201 ATP binding site [chemical binding]; other site 198628006202 Q-loop/lid; other site 198628006203 ABC transporter signature motif; other site 198628006204 Walker B; other site 198628006205 D-loop; other site 198628006206 H-loop/switch region; other site 198628006207 TOBE domain; Region: TOBE_2; pfam08402 198628006208 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198628006209 dimer interface [polypeptide binding]; other site 198628006210 conserved gate region; other site 198628006211 putative PBP binding loops; other site 198628006212 ABC-ATPase subunit interface; other site 198628006213 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 198628006214 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198628006215 dimer interface [polypeptide binding]; other site 198628006216 conserved gate region; other site 198628006217 putative PBP binding loops; other site 198628006218 ABC-ATPase subunit interface; other site 198628006219 Protein of unknown function (DUF2593); Region: DUF2593; pfam10767 198628006220 23S rRNA methyluridine methyltransferase; Reviewed; Region: rumB; PRK03522 198628006221 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 198628006222 S-adenosylmethionine binding site [chemical binding]; other site 198628006223 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198628006224 Major Facilitator Superfamily; Region: MFS_1; pfam07690 198628006225 putative substrate translocation pore; other site 198628006226 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 198628006227 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 198628006228 substrate binding pocket [chemical binding]; other site 198628006229 membrane-bound complex binding site; other site 198628006230 hinge residues; other site 198628006231 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198628006232 dimer interface [polypeptide binding]; other site 198628006233 conserved gate region; other site 198628006234 putative PBP binding loops; other site 198628006235 ABC-ATPase subunit interface; other site 198628006236 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 198628006237 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198628006238 dimer interface [polypeptide binding]; other site 198628006239 conserved gate region; other site 198628006240 putative PBP binding loops; other site 198628006241 ABC-ATPase subunit interface; other site 198628006242 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 198628006243 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 198628006244 substrate binding pocket [chemical binding]; other site 198628006245 membrane-bound complex binding site; other site 198628006246 hinge residues; other site 198628006247 arginine transporter ATP-binding subunit; Provisional; Region: artP; PRK11124 198628006248 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 198628006249 Walker A/P-loop; other site 198628006250 ATP binding site [chemical binding]; other site 198628006251 Q-loop/lid; other site 198628006252 ABC transporter signature motif; other site 198628006253 Walker B; other site 198628006254 D-loop; other site 198628006255 H-loop/switch region; other site 198628006256 hypothetical protein; Provisional; Region: PRK02877 198628006257 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 198628006258 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 198628006259 amidase catalytic site [active] 198628006260 Zn binding residues [ion binding]; other site 198628006261 substrate binding site [chemical binding]; other site 198628006262 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 198628006263 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 198628006264 NAD(P) binding site [chemical binding]; other site 198628006265 active site 198628006266 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 198628006267 HCP oxidoreductase, NADH-dependent; Provisional; Region: PRK10684 198628006268 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 198628006269 FAD binding pocket [chemical binding]; other site 198628006270 FAD binding motif [chemical binding]; other site 198628006271 phosphate binding motif [ion binding]; other site 198628006272 beta-alpha-beta structure motif; other site 198628006273 NAD binding pocket [chemical binding]; other site 198628006274 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 198628006275 catalytic loop [active] 198628006276 iron binding site [ion binding]; other site 198628006277 hybrid cluster protein; Provisional; Region: PRK05290 198628006278 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 198628006279 ACS interaction site; other site 198628006280 CODH interaction site; other site 198628006281 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 198628006282 hybrid metal cluster; other site 198628006283 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 198628006284 Protein of unknown function (DUF2813); Region: DUF2813; pfam11398 198628006285 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 198628006286 putative active site [active] 198628006287 putative metal-binding site [ion binding]; other site 198628006288 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 198628006289 DNA-binding site [nucleotide binding]; DNA binding site 198628006290 RNA-binding motif; other site 198628006291 Uncharacterized conserved protein [Function unknown]; Region: COG2127 198628006292 ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034 198628006293 Clp amino terminal domain; Region: Clp_N; pfam02861 198628006294 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 198628006295 Walker A motif; other site 198628006296 ATP binding site [chemical binding]; other site 198628006297 Walker B motif; other site 198628006298 arginine finger; other site 198628006299 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 198628006300 Walker A motif; other site 198628006301 ATP binding site [chemical binding]; other site 198628006302 Walker B motif; other site 198628006303 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 198628006304 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 198628006305 rRNA binding site [nucleotide binding]; other site 198628006306 predicted 30S ribosome binding site; other site 198628006307 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 198628006308 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160 198628006309 ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247 198628006310 Walker A/P-loop; other site 198628006311 ATP binding site [chemical binding]; other site 198628006312 Q-loop/lid; other site 198628006313 ABC transporter signature motif; other site 198628006314 Walker B; other site 198628006315 D-loop; other site 198628006316 H-loop/switch region; other site 198628006317 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11174 198628006318 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 198628006319 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 198628006320 Walker A/P-loop; other site 198628006321 ATP binding site [chemical binding]; other site 198628006322 Q-loop/lid; other site 198628006323 ABC transporter signature motif; other site 198628006324 Walker B; other site 198628006325 D-loop; other site 198628006326 H-loop/switch region; other site 198628006327 thioredoxin reductase; Provisional; Region: PRK10262 198628006328 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 198628006329 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 198628006330 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 198628006331 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 198628006332 putative DNA binding site [nucleotide binding]; other site 198628006333 putative Zn2+ binding site [ion binding]; other site 198628006334 AsnC family; Region: AsnC_trans_reg; pfam01037 198628006335 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 198628006336 DNA translocase FtsK; Provisional; Region: PRK10263 198628006337 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 198628006338 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 198628006339 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 198628006340 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 198628006341 recombination factor protein RarA; Reviewed; Region: PRK13342 198628006342 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 198628006343 Walker A motif; other site 198628006344 ATP binding site [chemical binding]; other site 198628006345 Walker B motif; other site 198628006346 arginine finger; other site 198628006347 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 198628006348 seryl-tRNA synthetase; Provisional; Region: PRK05431 198628006349 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 198628006350 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 198628006351 dimer interface [polypeptide binding]; other site 198628006352 active site 198628006353 motif 1; other site 198628006354 motif 2; other site 198628006355 motif 3; other site 198628006356 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 198628006357 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 198628006358 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 198628006359 putative C-terminal domain interface [polypeptide binding]; other site 198628006360 putative GSH binding site (G-site) [chemical binding]; other site 198628006361 putative dimer interface [polypeptide binding]; other site 198628006362 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 198628006363 N-terminal domain interface [polypeptide binding]; other site 198628006364 dimer interface [polypeptide binding]; other site 198628006365 substrate binding pocket (H-site) [chemical binding]; other site 198628006366 Predicted protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: COG3531 198628006367 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 198628006368 catalytic residues [active] 198628006369 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 198628006370 transcriptional regulator; Provisional; Region: PRK10632 198628006371 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 198628006372 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 198628006373 putative effector binding pocket; other site 198628006374 dimerization interface [polypeptide binding]; other site 198628006375 putative MFS family transporter protein; Provisional; Region: PRK03633 198628006376 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198628006377 putative substrate translocation pore; other site 198628006378 Transcriptional regulator [Transcription]; Region: LysR; COG0583 198628006379 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 198628006380 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 198628006381 dimerization interface [polypeptide binding]; other site 198628006382 pyruvate formate lyase-activating enzyme 1; Provisional; Region: pflA; PRK11145 198628006383 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 198628006384 FeS/SAM binding site; other site 198628006385 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 198628006386 Pyruvate formate lyase 1; Region: PFL1; cd01678 198628006387 coenzyme A binding site [chemical binding]; other site 198628006388 active site 198628006389 catalytic residues [active] 198628006390 glycine loop; other site 198628006391 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 198628006392 uncharacterized domain; Region: TIGR00702 198628006393 YcaO-like family; Region: YcaO; pfam02624 198628006394 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 198628006395 homodimer interface [polypeptide binding]; other site 198628006396 substrate-cofactor binding pocket; other site 198628006397 pyridoxal 5'-phosphate binding site [chemical binding]; other site 198628006398 catalytic residue [active] 198628006399 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 198628006400 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 198628006401 hinge; other site 198628006402 active site 198628006403 cytidylate kinase; Provisional; Region: cmk; PRK00023 198628006404 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 198628006405 CMP-binding site; other site 198628006406 The sites determining sugar specificity; other site 198628006407 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 198628006408 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 198628006409 RNA binding site [nucleotide binding]; other site 198628006410 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 198628006411 RNA binding site [nucleotide binding]; other site 198628006412 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689 198628006413 RNA binding site [nucleotide binding]; other site 198628006414 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 198628006415 RNA binding site [nucleotide binding]; other site 198628006416 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 198628006417 RNA binding site [nucleotide binding]; other site 198628006418 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 198628006419 IHF dimer interface [polypeptide binding]; other site 198628006420 IHF - DNA interface [nucleotide binding]; other site 198628006421 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 198628006422 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 198628006423 active site 198628006425 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 198628006426 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 198628006427 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 198628006428 metal binding site [ion binding]; metal-binding site 198628006429 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 198628006430 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 198628006431 substrate binding site [chemical binding]; other site 198628006432 glutamase interaction surface [polypeptide binding]; other site 198628006433 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 198628006434 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 198628006435 catalytic residues [active] 198628006436 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13170 198628006437 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 198628006438 putative active site [active] 198628006439 oxyanion strand; other site 198628006440 catalytic triad [active] 198628006441 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446 198628006442 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 198628006443 active site 198628006444 motif I; other site 198628006445 motif II; other site 198628006446 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 198628006447 putative active site pocket [active] 198628006448 4-fold oligomerization interface [polypeptide binding]; other site 198628006449 metal binding residues [ion binding]; metal-binding site 198628006450 3-fold/trimer interface [polypeptide binding]; other site 198628006451 histidinol-phosphate aminotransferase; Provisional; Region: PRK01688 198628006452 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 198628006453 pyridoxal 5'-phosphate binding site [chemical binding]; other site 198628006454 homodimer interface [polypeptide binding]; other site 198628006455 catalytic residue [active] 198628006456 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 198628006457 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 198628006458 NAD binding site [chemical binding]; other site 198628006459 dimerization interface [polypeptide binding]; other site 198628006460 product binding site; other site 198628006461 substrate binding site [chemical binding]; other site 198628006462 zinc binding site [ion binding]; other site 198628006463 catalytic residues [active] 198628006464 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 198628006465 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 198628006466 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 198628006467 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 198628006468 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 198628006469 putative NAD(P) binding site [chemical binding]; other site 198628006470 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 198628006471 dimerization interface [polypeptide binding]; other site 198628006472 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 198628006473 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 198628006474 dimer interface [polypeptide binding]; other site 198628006475 putative CheW interface [polypeptide binding]; other site 198628006476 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 198628006477 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 198628006478 active site 198628006479 phosphorylation site [posttranslational modification] 198628006480 intermolecular recognition site; other site 198628006481 dimerization interface [polypeptide binding]; other site 198628006482 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 198628006483 sensor histidine kinase DpiB; Provisional; Region: dpiB; PRK15053 198628006484 PAS domain; Region: PAS; smart00091 198628006485 putative active site [active] 198628006486 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 198628006487 ATP binding site [chemical binding]; other site 198628006488 Mg2+ binding site [ion binding]; other site 198628006489 G-X-G motif; other site 198628006490 2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390 198628006491 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 198628006492 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 198628006493 Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053 198628006494 Citrate lyase ligase; Region: Citrate_lyase_ligase; cd02169 198628006495 putative active site [active] 198628006496 (T/H)XGH motif; other site 198628006497 citrate lyase subunit gamma; Provisional; Region: PRK13253 198628006498 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 198628006499 Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051 198628006500 Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase; Region: CitX; pfam03802 198628006501 triphosphoribosyl-dephospho-CoA synthase CitG; Region: citrate_citG; TIGR03125 198628006502 Flagellar regulator YcgR; Region: YcgR; pfam07317 198628006503 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 198628006504 PilZ domain; Region: PilZ; pfam07238 198628006505 amino acid transporter; Region: 2A0306; TIGR00909 198628006506 exonuclease I; Provisional; Region: sbcB; PRK11779 198628006507 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 198628006508 active site 198628006509 catalytic site [active] 198628006510 substrate binding site [chemical binding]; other site 198628006511 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 198628006512 hypothetical protein; Provisional; Region: PRK05423 198628006513 ycaI pseudogene containing N-terminal deletion and internal framshift resulting in two open reading frames, ycaI_1 and ycaI_2 198628006514 lipid transporter ATP-binding/permease protein; Provisional; Region: PRK11176 198628006515 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 198628006516 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 198628006517 Walker A/P-loop; other site 198628006518 ATP binding site [chemical binding]; other site 198628006519 Q-loop/lid; other site 198628006520 ABC transporter signature motif; other site 198628006521 Walker B; other site 198628006522 D-loop; other site 198628006523 H-loop/switch region; other site 198628006524 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 198628006525 tetraacyldisaccharide 4'-kinase; Region: lpxK; TIGR00682 198628006526 Trm112p-like protein; Region: Trm112p; cl01066 198628006527 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 198628006528 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 198628006529 Ligand binding site; other site 198628006530 oligomer interface; other site 198628006531 Right handed beta helix region; Region: Beta_helix; pfam13229 198628006532 hypothetical protein; Provisional; Region: PRK10593 198628006533 Uncharacterized conserved protein [Function unknown]; Region: COG1434 198628006534 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 198628006535 putative active site [active] 198628006536 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 198628006537 Methyltransferase domain; Region: Methyltransf_31; pfam13847 198628006538 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 198628006539 S-adenosylmethionine binding site [chemical binding]; other site 198628006540 condesin subunit F; Provisional; Region: PRK05260 198628006541 condesin subunit E; Provisional; Region: PRK05256 198628006542 cell division protein MukB; Provisional; Region: mukB; PRK04863 198628006543 P-loop containing region of AAA domain; Region: AAA_29; cl17516 198628006544 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 198628006545 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 198628006546 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 198628006547 potential frameshift: common BLAST hit: gi|298492042|ref|YP_003722219.1| glutathione synthase 198628006548 cyanophycin synthetase; Provisional; Region: PRK14016 198628006549 ATP-grasp domain; Region: ATP-grasp_4; cl17255 198628006550 multicopper oxidase; Provisional; Region: PRK10965 198628006551 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 198628006552 Copper resistance protein B precursor (CopB); Region: CopB; cl01476 198628006553 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 198628006554 Predicted transcriptional regulators [Transcription]; Region: COG1733 198628006555 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 198628006556 dimerization interface [polypeptide binding]; other site 198628006557 putative DNA binding site [nucleotide binding]; other site 198628006558 putative Zn2+ binding site [ion binding]; other site 198628006559 Old yellow enzyme (OYE)-related FMN binding domain, group 5. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_5_FMN; cd04747 198628006560 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 198628006561 putative active site [active] 198628006562 putative FMN binding site [chemical binding]; other site 198628006563 putative substrate binding site [chemical binding]; other site 198628006564 putative catalytic residue [active] 198628006565 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 198628006566 nudix motif; other site 198628006567 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062 198628006568 B1 nucleotide binding pocket [chemical binding]; other site 198628006569 B2 nucleotide binding pocket [chemical binding]; other site 198628006570 CAS motifs; other site 198628006571 active site 198628006572 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 198628006573 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 198628006574 dimer interface [polypeptide binding]; other site 198628006575 ADP-ribose binding site [chemical binding]; other site 198628006576 active site 198628006577 nudix motif; other site 198628006578 metal binding site [ion binding]; metal-binding site 198628006579 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 198628006580 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 198628006581 DNA-binding site [nucleotide binding]; DNA binding site 198628006582 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 198628006583 transcriptional regulator pseudogene containing internal frameshift, split into two open reading frames 198628006584 Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564 198628006585 Predicted amidohydrolase [General function prediction only]; Region: COG0388 198628006586 putative active site [active] 198628006587 catalytic triad [active] 198628006588 putative dimer interface [polypeptide binding]; other site 198628006589 putative hydrolase; Validated; Region: PRK09248 198628006590 Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437 198628006591 active site 198628006592 Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381 198628006593 lipoprotein; Provisional; Region: PRK10598 198628006594 glutaredoxin 2; Provisional; Region: PRK10387 198628006595 GST_N family, Glutaredoxin 2 (GRX2) subfamily; composed of bacterial proteins similar to E. coli GRX2, an atypical GRX with a molecular mass of about 24kD, compared with other GRXs which are 9-12kD in size. GRX2 adopts a GST fold containing an N-terminal...; Region: GST_N_GRX2; cd03037 198628006596 C-terminal domain interface [polypeptide binding]; other site 198628006597 GSH binding site (G-site) [chemical binding]; other site 198628006598 catalytic residues [active] 198628006599 putative dimer interface [polypeptide binding]; other site 198628006600 C-terminal, alpha helical domain of Glutaredoxin 2; Region: GST_C_GRX2; cd03199 198628006601 N-terminal domain interface [polypeptide binding]; other site 198628006602 multidrug resistance protein MdtH; Provisional; Region: PRK11646 198628006603 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198628006604 putative substrate translocation pore; other site 198628006605 ribosomal-protein-S5-alanine N-acetyltransferase; Provisional; Region: PRK10809 198628006606 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 198628006607 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3132 198628006608 hypothetical protein; Provisional; Region: PRK11239 198628006609 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 198628006610 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 198628006611 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 198628006612 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 198628006613 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 198628006614 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 198628006615 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 198628006616 active site 198628006617 HIGH motif; other site 198628006618 KMSK motif region; other site 198628006619 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 198628006620 tRNA binding surface [nucleotide binding]; other site 198628006621 anticodon binding site; other site 198628006622 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_4; cd07268 198628006623 putative metal binding site [ion binding]; other site 198628006624 copper homeostasis protein CutC; Provisional; Region: PRK11572 198628006625 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 198628006626 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 198628006627 S-adenosylmethionine binding site [chemical binding]; other site 198628006628 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 198628006629 S-adenosylmethionine binding site [chemical binding]; other site 198628006630 Uncharacterized relative of glutathione S-transferase, MAPEG superfamily [General function prediction only]; Region: COG3788 198628006631 hypothetical protein; Provisional; Region: PRK10302 198628006632 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 198628006633 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 198628006634 dimer interface [polypeptide binding]; other site 198628006635 anticodon binding site; other site 198628006636 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 198628006637 homodimer interface [polypeptide binding]; other site 198628006638 motif 1; other site 198628006639 active site 198628006640 motif 2; other site 198628006641 GAD domain; Region: GAD; pfam02938 198628006642 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 198628006643 active site 198628006644 motif 3; other site 198628006645 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 198628006646 nudix motif; other site 198628006647 hypothetical protein; Validated; Region: PRK00110 198628006648 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 198628006649 active site 198628006650 putative DNA-binding cleft [nucleotide binding]; other site 198628006651 dimer interface [polypeptide binding]; other site 198628006652 High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376 198628006653 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 198628006654 RuvA N terminal domain; Region: RuvA_N; pfam01330 198628006655 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 198628006656 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 198628006657 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 198628006658 Walker A motif; other site 198628006659 ATP binding site [chemical binding]; other site 198628006660 Walker B motif; other site 198628006661 arginine finger; other site 198628006662 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 198628006663 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 198628006664 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 198628006665 ABC-ATPase subunit interface; other site 198628006666 dimer interface [polypeptide binding]; other site 198628006667 putative PBP binding regions; other site 198628006668 high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544 198628006669 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 198628006670 high-affinity zinc transporter periplasmic component; Reviewed; Region: znuA; PRK09545 198628006671 Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019 198628006672 metal binding site [ion binding]; metal-binding site 198628006673 putative peptidase; Provisional; Region: PRK11649 198628006674 Opacity-associated protein A N-terminal motif; Region: OapA_N; pfam08525 198628006675 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 198628006676 Peptidase family M23; Region: Peptidase_M23; pfam01551 198628006677 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 198628006678 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 198628006679 putative acyl-acceptor binding pocket; other site 198628006680 pyruvate kinase; Provisional; Region: PRK05826 198628006681 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 198628006682 domain interfaces; other site 198628006683 active site 198628006684 DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302 198628006685 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 198628006686 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 198628006687 putative active site [active] 198628006688 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 198628006689 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 198628006690 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 198628006691 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 198628006692 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 198628006693 active site 198628006694 intersubunit interface [polypeptide binding]; other site 198628006695 catalytic residue [active] 198628006696 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 198628006697 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 198628006698 ATP-grasp domain; Region: ATP-grasp; pfam02222 198628006699 protease 2; Provisional; Region: PRK10115 198628006700 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 198628006701 DNA polymerase III subunit theta; Reviewed; Region: PRK10969 198628006702 CopC domain; Region: CopC; pfam04234 198628006703 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 198628006704 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 198628006705 Ferritin-like domain; Region: Ferritin; pfam00210 198628006706 ferroxidase diiron center [ion binding]; other site 198628006707 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cl00089 198628006708 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 198628006709 active site 198628006710 substrate binding site [chemical binding]; other site 198628006711 Mg2+ binding site [ion binding]; other site 198628006712 Response regulator receiver domain; Region: Response_reg; pfam00072 198628006713 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 198628006714 active site 198628006715 phosphorylation site [posttranslational modification] 198628006716 intermolecular recognition site; other site 198628006717 dimerization interface [polypeptide binding]; other site 198628006718 HD domain; Region: HD_5; pfam13487 198628006719 Response regulator receiver domain; Region: Response_reg; pfam00072 198628006720 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 198628006721 active site 198628006722 phosphorylation site [posttranslational modification] 198628006723 intermolecular recognition site; other site 198628006724 dimerization interface [polypeptide binding]; other site 198628006725 HDOD domain; Region: HDOD; pfam08668 198628006726 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 198628006727 ATP binding site [chemical binding]; other site 198628006728 Mg2+ binding site [ion binding]; other site 198628006729 G-X-G motif; other site 198628006730 Uncharacterized conserved protein [Function unknown]; Region: COG3287 198628006731 FIST N domain; Region: FIST; pfam08495 198628006732 FIST C domain; Region: FIST_C; pfam10442 198628006733 Protein of unknown function (DUF2511); Region: DUF2511; pfam10709 198628006734 hypothetical protein; Provisional; Region: PRK10457 198628006735 nickel ABC transporter, permease subunit NikB; Region: nickel_nikB; TIGR02789 198628006736 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 198628006737 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 198628006738 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 198628006739 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 198628006740 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 198628006741 Walker A/P-loop; other site 198628006742 ATP binding site [chemical binding]; other site 198628006743 Q-loop/lid; other site 198628006744 ABC transporter signature motif; other site 198628006745 Walker B; other site 198628006746 D-loop; other site 198628006747 H-loop/switch region; other site 198628006748 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 198628006749 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 198628006750 Walker A/P-loop; other site 198628006751 ATP binding site [chemical binding]; other site 198628006752 Q-loop/lid; other site 198628006753 ABC transporter signature motif; other site 198628006754 Walker B; other site 198628006755 D-loop; other site 198628006756 H-loop/switch region; other site 198628006757 hypothetical protein; Provisional; Region: PRK05325 198628006758 PrkA family serine protein kinase; Provisional; Region: PRK15455 198628006759 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 198628006760 Walker A motif; other site 198628006761 ATP binding site [chemical binding]; other site 198628006762 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 198628006763 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 198628006764 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 198628006765 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 198628006766 active site 198628006767 catalytic tetrad [active] 198628006768 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 198628006769 active site 198628006770 phosphate binding residues; other site 198628006771 catalytic residues [active] 198628006772 glyceraldehyde-3-phosphate dehydrogenase A; Provisional; Region: gapA; PRK15425 198628006773 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 198628006774 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 198628006775 methionine sulfoxide reductase B; Provisional; Region: PRK00222 198628006776 SelR domain; Region: SelR; pfam01641 198628006777 Protein of unknown function (DUF1315); Region: DUF1315; cl01215 198628006778 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 198628006779 Isochorismatase family; Region: Isochorismatase; pfam00857 198628006780 catalytic triad [active] 198628006781 metal binding site [ion binding]; metal-binding site 198628006782 conserved cis-peptide bond; other site 198628006783 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 198628006784 active site 198628006785 homodimer interface [polypeptide binding]; other site 198628006786 protease 4; Provisional; Region: PRK10949 198628006787 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 198628006788 tandem repeat interface [polypeptide binding]; other site 198628006789 oligomer interface [polypeptide binding]; other site 198628006790 active site residues [active] 198628006791 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_1; cd07019 198628006792 tandem repeat interface [polypeptide binding]; other site 198628006793 oligomer interface [polypeptide binding]; other site 198628006794 active site residues [active] 198628006795 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 198628006796 putative FMN binding site [chemical binding]; other site 198628006797 DNA topoisomerase III; Provisional; Region: PRK07726 198628006798 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 198628006799 active site 198628006800 putative interdomain interaction site [polypeptide binding]; other site 198628006801 putative metal-binding site [ion binding]; other site 198628006802 putative nucleotide binding site [chemical binding]; other site 198628006803 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 198628006804 domain I; other site 198628006805 DNA binding groove [nucleotide binding] 198628006806 phosphate binding site [ion binding]; other site 198628006807 domain II; other site 198628006808 domain III; other site 198628006809 nucleotide binding site [chemical binding]; other site 198628006810 catalytic site [active] 198628006811 domain IV; other site 198628006812 Protein of unknown function (DUF1496); Region: DUF1496; pfam07383 198628006813 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 198628006814 putative catalytic site [active] 198628006815 putative phosphate binding site [ion binding]; other site 198628006816 active site 198628006817 metal binding site A [ion binding]; metal-binding site 198628006818 DNA binding site [nucleotide binding] 198628006819 putative AP binding site [nucleotide binding]; other site 198628006820 putative metal binding site B [ion binding]; other site 198628006821 Predicted membrane protein [Function unknown]; Region: COG2860 198628006822 UPF0126 domain; Region: UPF0126; pfam03458 198628006823 UPF0126 domain; Region: UPF0126; pfam03458 198628006824 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 198628006825 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 198628006826 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 198628006827 putative active site [active] 198628006828 putative substrate binding site [chemical binding]; other site 198628006829 putative cosubstrate binding site; other site 198628006830 catalytic site [active] 198628006831 SEC-C motif; Region: SEC-C; pfam02810 198628006832 hypothetical protein; Provisional; Region: PRK04233 198628006833 hypothetical protein; Provisional; Region: PRK10279 198628006834 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 198628006835 active site 198628006836 nucleophile elbow; other site 198628006838 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 198628006839 active site 198628006840 tetramer interface; other site 198628006841 global DNA-binding transcriptional dual regulator H-NS; Provisional; Region: PRK10947 198628006842 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 198628006843 thymidine kinase; Provisional; Region: PRK04296 198628006844 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 198628006845 ATP binding site [chemical binding]; other site 198628006846 Walker A motif; other site 198628006847 Walker B motif; other site 198628006848 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 198628006849 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 198628006850 putative catalytic cysteine [active] 198628006851 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 198628006852 putative active site [active] 198628006853 metal binding site [ion binding]; metal-binding site 198628006854 hypothetical protein; Provisional; Region: PRK11111 198628006855 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 198628006856 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 198628006857 peptide binding site [polypeptide binding]; other site 198628006858 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 198628006859 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198628006860 dimer interface [polypeptide binding]; other site 198628006861 conserved gate region; other site 198628006862 putative PBP binding loops; other site 198628006863 ABC-ATPase subunit interface; other site 198628006864 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 198628006865 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 198628006866 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198628006867 dimer interface [polypeptide binding]; other site 198628006868 conserved gate region; other site 198628006869 ABC-ATPase subunit interface; other site 198628006870 oligopeptide transporter ATP-binding component; Provisional; Region: oppD; PRK09473 198628006871 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 198628006872 Walker A/P-loop; other site 198628006873 ATP binding site [chemical binding]; other site 198628006874 Q-loop/lid; other site 198628006875 ABC transporter signature motif; other site 198628006876 Walker B; other site 198628006877 D-loop; other site 198628006878 H-loop/switch region; other site 198628006879 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 198628006880 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 198628006881 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 198628006882 Walker A/P-loop; other site 198628006883 ATP binding site [chemical binding]; other site 198628006884 Q-loop/lid; other site 198628006885 ABC transporter signature motif; other site 198628006886 Walker B; other site 198628006887 D-loop; other site 198628006888 H-loop/switch region; other site 198628006889 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 198628006890 dsDNA-mimic protein; Reviewed; Region: PRK05094 198628006891 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 198628006892 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 198628006893 Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152 198628006894 putative active site [active] 198628006895 catalytic site [active] 198628006896 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158 198628006897 putative active site [active] 198628006898 catalytic site [active] 198628006899 Transposase IS200 like; Region: Y1_Tnp; pfam01797 198628006900 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 198628006901 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 198628006902 dimer interface [polypeptide binding]; other site 198628006903 ligand binding site [chemical binding]; other site 198628006904 HAMP domain; Region: HAMP; pfam00672 198628006905 dimerization interface [polypeptide binding]; other site 198628006906 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 198628006907 dimer interface [polypeptide binding]; other site 198628006908 putative CheW interface [polypeptide binding]; other site 198628006909 YciI-like protein; Reviewed; Region: PRK11370 198628006910 transport protein TonB; Provisional; Region: PRK10819 198628006911 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 198628006912 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 198628006913 intracellular septation protein A; Reviewed; Region: PRK00259 198628006914 hypothetical protein; Provisional; Region: PRK02868 198628006915 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 198628006916 outer membrane protein W; Provisional; Region: PRK10959 198628006917 Oligogalacturonate-specific porin protein (KdgM); Region: KdgM; cl11629 198628006918 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 198628006919 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 198628006920 substrate binding site [chemical binding]; other site 198628006921 active site 198628006922 catalytic residues [active] 198628006923 heterodimer interface [polypeptide binding]; other site 198628006924 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 198628006925 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 198628006926 pyridoxal 5'-phosphate binding site [chemical binding]; other site 198628006927 catalytic residue [active] 198628006928 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 198628006929 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 198628006930 active site 198628006931 ribulose/triose binding site [chemical binding]; other site 198628006932 phosphate binding site [ion binding]; other site 198628006933 substrate (anthranilate) binding pocket [chemical binding]; other site 198628006934 product (indole) binding pocket [chemical binding]; other site 198628006935 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 198628006936 active site 198628006937 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 198628006938 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 198628006939 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 198628006940 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 198628006941 Glutamine amidotransferase class-I; Region: GATase; pfam00117 198628006942 glutamine binding [chemical binding]; other site 198628006943 catalytic triad [active] 198628006944 anthranilate synthase component I; Provisional; Region: PRK13564 198628006945 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 198628006946 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 198628006947 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 198628006948 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 198628006949 active site 198628006950 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 198628006951 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 198628006952 23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700 198628006953 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 198628006954 RNA binding surface [nucleotide binding]; other site 198628006955 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 198628006956 probable active site [active] 198628006957 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 198628006958 Cob(I)alamin adenosyltransferase N terminal; Region: Co_AT_N; pfam12557 198628006959 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 198628006960 homodimer interface [polypeptide binding]; other site 198628006961 Walker A motif; other site 198628006962 ATP binding site [chemical binding]; other site 198628006963 hydroxycobalamin binding site [chemical binding]; other site 198628006964 Walker B motif; other site 198628006965 putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945 198628006966 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 198628006967 NAD(P) binding site [chemical binding]; other site 198628006968 active site 198628006969 Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496 198628006970 putative inner membrane peptidase; Provisional; Region: PRK11778 198628006971 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 198628006972 tandem repeat interface [polypeptide binding]; other site 198628006973 oligomer interface [polypeptide binding]; other site 198628006974 active site residues [active] 198628006975 hypothetical protein; Provisional; Region: PRK11037 198628006976 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 198628006977 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 198628006978 active site 198628006979 interdomain interaction site; other site 198628006980 putative metal-binding site [ion binding]; other site 198628006981 nucleotide binding site [chemical binding]; other site 198628006982 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 198628006983 domain I; other site 198628006984 DNA binding groove [nucleotide binding] 198628006985 phosphate binding site [ion binding]; other site 198628006986 domain II; other site 198628006987 domain III; other site 198628006988 nucleotide binding site [chemical binding]; other site 198628006989 catalytic site [active] 198628006990 domain IV; other site 198628006991 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 198628006992 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 198628006993 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 198628006994 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 198628006995 transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681 198628006996 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 198628006997 The C-terminal substrate domain of LysR-type transcriptional regulator CysB contains type 2 periplasmic binding fold; Region: PBP2_CysB; cd08443 198628006998 substrate binding site [chemical binding]; other site 198628006999 putative dimerization interface [polypeptide binding]; other site 198628007000 endonuclease III; Provisional; Region: PRK10702 198628007001 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 198628007002 minor groove reading motif; other site 198628007003 helix-hairpin-helix signature motif; other site 198628007004 substrate binding pocket [chemical binding]; other site 198628007005 active site 198628007006 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 198628007007 electron transport complex RsxE subunit; Provisional; Region: PRK12405 198628007008 electron transport complex protein RnfG; Validated; Region: PRK01908 198628007009 electron transport complex protein RnfD; Reviewed; Region: rnfD; PRK00816 198628007010 Predicted NADH:ubiquinone oxidoreductase, subunit RnfC [Energy production and conversion]; Region: RnfC; COG4656 198628007011 SLBB domain; Region: SLBB; pfam10531 198628007012 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 198628007013 electron transport complex protein RnfB; Provisional; Region: PRK05113 198628007014 Putative Fe-S cluster; Region: FeS; pfam04060 198628007015 4Fe-4S binding domain; Region: Fer4; pfam00037 198628007016 electron transport complex protein RsxA; Provisional; Region: PRK05151 198628007017 oriC-binding nucleoid-associated protein; Provisional; Region: PRK10391 198628007018 L-arabinose isomerase; Provisional; Region: PRK02929 198628007019 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 198628007020 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 198628007021 trimer interface [polypeptide binding]; other site 198628007022 putative substrate binding site [chemical binding]; other site 198628007023 putative metal binding site [ion binding]; other site 198628007024 ribulokinase; Provisional; Region: PRK04123 198628007025 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 198628007026 N- and C-terminal domain interface [polypeptide binding]; other site 198628007027 active site 198628007028 MgATP binding site [chemical binding]; other site 198628007029 catalytic site [active] 198628007030 metal binding site [ion binding]; metal-binding site 198628007031 carbohydrate binding site [chemical binding]; other site 198628007032 homodimer interface [polypeptide binding]; other site 198628007033 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 198628007034 Periplasmic L-arabinose-binding protein (ABP), a member of a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein superfamily; Region: PBP1_arabinose_binding; cd01540 198628007035 ligand binding site [chemical binding]; other site 198628007036 L-arabinose transporter ATP-binding protein; Provisional; Region: araG; PRK11288 198628007037 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 198628007038 Walker A/P-loop; other site 198628007039 ATP binding site [chemical binding]; other site 198628007040 Q-loop/lid; other site 198628007041 ABC transporter signature motif; other site 198628007042 Walker B; other site 198628007043 D-loop; other site 198628007044 H-loop/switch region; other site 198628007045 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 198628007046 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 198628007047 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 198628007048 TM-ABC transporter signature motif; other site 198628007049 DNA-binding transcriptional regulator AraC; Provisional; Region: PRK10572 198628007050 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 198628007051 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 198628007052 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 198628007053 putative oxidoreductase; Provisional; Region: PRK11579 198628007054 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 198628007055 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 198628007056 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 198628007057 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 198628007058 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 198628007059 adenosine deaminase; Provisional; Region: PRK09358 198628007060 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 198628007061 active site 198628007062 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 198628007063 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 198628007064 putative Zn2+ binding site [ion binding]; other site 198628007065 putative DNA binding site [nucleotide binding]; other site 198628007066 AsnC family; Region: AsnC_trans_reg; pfam01037 198628007067 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339 198628007068 Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097 198628007069 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 198628007070 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 198628007071 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 198628007072 fumarate hydratase; Reviewed; Region: fumC; PRK00485 198628007073 Class II fumarases; Region: Fumarase_classII; cd01362 198628007074 active site 198628007075 tetramer interface [polypeptide binding]; other site 198628007076 DNA replication terminus site-binding protein; Provisional; Region: PRK02951 198628007077 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 198628007078 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198628007079 putative substrate translocation pore; other site 198628007080 Transcriptional regulator [Transcription]; Region: LysR; COG0583 198628007081 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 198628007082 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 198628007083 dimerization interface [polypeptide binding]; other site 198628007084 substrate binding pocket [chemical binding]; other site 198628007085 MarR family; Region: MarR_2; cl17246 198628007086 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 198628007087 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 198628007088 nucleotide binding site [chemical binding]; other site 198628007089 putative dithiobiotin synthetase; Provisional; Region: PRK12374 198628007090 AAA domain; Region: AAA_26; pfam13500 198628007091 Protein of unknown function (DUF1161); Region: DUF1161; pfam06649 198628007092 Protein of unknown function (DUF1283); Region: DUF1283; cl11644 198628007093 malonic semialdehyde reductase; Provisional; Region: PRK10538 198628007094 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 198628007095 putative NAD(P) binding site [chemical binding]; other site 198628007096 homotetramer interface [polypeptide binding]; other site 198628007097 homodimer interface [polypeptide binding]; other site 198628007098 active site 198628007099 Methyltransferase domain; Region: Methyltransf_31; pfam13847 198628007100 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 198628007101 S-adenosylmethionine binding site [chemical binding]; other site 198628007102 putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915 198628007103 mannosyl-3-phosphoglycerate phosphatase; Reviewed; Region: PRK03669 198628007104 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 198628007105 active site 198628007106 motif I; other site 198628007107 motif II; other site 198628007108 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 198628007109 Coenzyme A binding pocket [chemical binding]; other site 198628007110 predicted Dif; recA-independent recombination site in terminus 198628007111 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 198628007112 Acyltransferase family; Region: Acyl_transf_3; pfam01757 198628007113 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 198628007114 Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes TehA protein; Region: TDT_TehA; cd09324 198628007115 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 198628007116 gating phenylalanine in ion channel; other site 198628007117 Protein of unknown function (DUF1706); Region: DUF1706; cl01748 198628007118 Endoglucanase C-terminal domain/subunit and related proteins [Carbohydrate transport and metabolism]; Region: COG4305 198628007119 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 198628007120 Protein of unknown function (DUF3313); Region: DUF3313; pfam11769 198628007121 Paraquat-inducible protein A; Region: PqiA; pfam04403 198628007122 Paraquat-inducible protein A; Region: PqiA; pfam04403 198628007123 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 198628007124 mce related protein; Region: MCE; pfam02470 198628007125 mce related protein; Region: MCE; pfam02470 198628007126 mce related protein; Region: MCE; pfam02470 198628007127 Protein of unknown function (DUF330); Region: DUF330; pfam03886 198628007128 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 198628007129 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 198628007130 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 198628007131 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 198628007132 K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158 198628007133 potassium uptake protein; Region: kup; TIGR00794 198628007134 Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases are important virulence factors in pathogenic bacteria. They may be secreted into the medium via a mechanism found in gram-negative bacteria, that does not...; Region: ZnMc_serralysin_like; cd04277 198628007135 active site 198628007136 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 198628007137 Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases are important virulence factors in pathogenic bacteria. They may be secreted into the medium via a mechanism found in gram-negative bacteria, that does not...; Region: ZnMc_serralysin_like; cd04277 198628007138 active site 198628007139 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 198628007140 Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases are important virulence factors in pathogenic bacteria. They may be secreted into the medium via a mechanism found in gram-negative bacteria, that does not...; Region: ZnMc_serralysin_like; cd04277 198628007141 active site 198628007142 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 198628007143 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 198628007144 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 198628007145 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 198628007146 HlyD family secretion protein; Region: HlyD_3; pfam13437 198628007147 type I secretion system ABC transporter, PrtD family; Region: type_I_sec_PrtD; TIGR01842 198628007148 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 198628007149 Walker A/P-loop; other site 198628007150 ATP binding site [chemical binding]; other site 198628007151 Q-loop/lid; other site 198628007152 ABC transporter signature motif; other site 198628007153 Walker B; other site 198628007154 D-loop; other site 198628007155 H-loop/switch region; other site 198628007156 Protease inhibitor Inh; Region: Inh; pfam02974 198628007157 Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases are important virulence factors in pathogenic bacteria. They may be secreted into the medium via a mechanism found in gram-negative bacteria, that does not...; Region: ZnMc_serralysin_like; cd04277 198628007158 active site 198628007159 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 198628007160 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 198628007161 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 198628007162 NADP binding site [chemical binding]; other site 198628007163 Virulence factor SrfB; Region: SrfB; pfam07520 198628007164 Putative bacterial virulence factor; Region: Virul_Fac; pfam10139 198628007165 Membrane bound FAD containing D-sorbitol dehydrogenase; Region: FAD-SLDH; pfam12318 198628007166 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 198628007167 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 198628007168 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 198628007169 Ferritin-like; Region: Ferritin-like; pfam12902 198628007170 SnoaL-like domain; Region: SnoaL_2; pfam12680 198628007171 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 198628007172 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 198628007173 active site 198628007174 cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454 198628007175 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 198628007176 active site 198628007177 catalytic site [active] 198628007178 hypothetical protein; Provisional; Region: PRK11622 198628007179 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 198628007180 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 198628007181 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198628007182 dimer interface [polypeptide binding]; other site 198628007183 conserved gate region; other site 198628007184 putative PBP binding loops; other site 198628007185 ABC-ATPase subunit interface; other site 198628007186 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198628007187 dimer interface [polypeptide binding]; other site 198628007188 conserved gate region; other site 198628007189 putative PBP binding loops; other site 198628007190 ABC-ATPase subunit interface; other site 198628007191 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 198628007192 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 198628007193 Walker A/P-loop; other site 198628007194 ATP binding site [chemical binding]; other site 198628007195 Q-loop/lid; other site 198628007196 ABC transporter signature motif; other site 198628007197 Walker B; other site 198628007198 D-loop; other site 198628007199 H-loop/switch region; other site 198628007200 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 198628007201 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 198628007202 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 198628007203 Transcriptional regulator [Transcription]; Region: LysR; COG0583 198628007204 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 198628007205 LysR substrate binding domain; Region: LysR_substrate; pfam03466 198628007206 dimerization interface [polypeptide binding]; other site 198628007207 Phenolic acid decarboxylase (PAD); Region: PA_decarbox; cl01382 198628007208 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 198628007209 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 198628007210 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 198628007211 dimerization interface [polypeptide binding]; other site 198628007212 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 198628007213 dimer interface [polypeptide binding]; other site 198628007214 putative CheW interface [polypeptide binding]; other site 198628007215 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 198628007216 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 198628007217 E-class dimer interface [polypeptide binding]; other site 198628007218 P-class dimer interface [polypeptide binding]; other site 198628007219 active site 198628007220 Cu2+ binding site [ion binding]; other site 198628007221 Zn2+ binding site [ion binding]; other site 198628007222 FIST N domain; Region: FIST; smart00897 198628007223 FIST C domain; Region: FIST_C; pfam10442 198628007224 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 198628007225 dimer interface [polypeptide binding]; other site 198628007226 putative CheW interface [polypeptide binding]; other site 198628007227 O-6-alkylguanine-DNA:cysteine-protein methyltransferase; Provisional; Region: PRK10286 198628007228 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 198628007229 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 198628007230 DNA binding site [nucleotide binding] 198628007231 active site 198628007232 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 198628007233 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 198628007234 ligand binding site [chemical binding]; other site 198628007235 flexible hinge region; other site 198628007236 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 198628007237 putative switch regulator; other site 198628007238 non-specific DNA interactions [nucleotide binding]; other site 198628007239 DNA binding site [nucleotide binding] 198628007240 sequence specific DNA binding site [nucleotide binding]; other site 198628007241 putative cAMP binding site [chemical binding]; other site 198628007242 universal stress protein UspE; Provisional; Region: PRK11175 198628007243 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 198628007244 Ligand Binding Site [chemical binding]; other site 198628007245 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 198628007246 Ligand Binding Site [chemical binding]; other site 198628007247 pyridine nucleotide transhydrogenase; Provisional; Region: pntB; PRK09444 198628007248 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 198628007249 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 198628007250 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 198628007251 ligand binding site [chemical binding]; other site 198628007252 homodimer interface [polypeptide binding]; other site 198628007253 NAD(P) binding site [chemical binding]; other site 198628007254 trimer interface B [polypeptide binding]; other site 198628007255 trimer interface A [polypeptide binding]; other site 198628007256 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 198628007257 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 198628007258 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 198628007259 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 198628007260 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 198628007261 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 198628007262 hypothetical protein; Provisional; Region: PRK10941 198628007263 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 198628007264 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 198628007265 binding surface 198628007266 TPR motif; other site 198628007267 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 198628007268 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 198628007269 peptide chain release factor 1; Validated; Region: prfA; PRK00591 198628007270 This domain is found in peptide chain release factors; Region: PCRF; smart00937 198628007271 RF-1 domain; Region: RF-1; pfam00472 198628007272 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 198628007273 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 198628007274 tRNA; other site 198628007275 putative tRNA binding site [nucleotide binding]; other site 198628007276 putative NADP binding site [chemical binding]; other site 198628007277 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 198628007278 outer membrane lipoprotein LolB; Provisional; Region: lolB; PRK00022 198628007279 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 198628007280 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 198628007281 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 198628007282 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 198628007283 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 198628007284 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 198628007285 active site 198628007286 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 198628007287 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 198628007288 Transcriptional regulator [Transcription]; Region: LysR; COG0583 198628007289 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 198628007290 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 198628007291 putative effector binding pocket; other site 198628007292 putative dimerization interface [polypeptide binding]; other site 198628007293 hypothetical protein; Provisional; Region: PRK10692 198628007294 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 198628007295 putative active site [active] 198628007296 catalytic residue [active] 198628007297 GTP-binding protein YchF; Reviewed; Region: PRK09601 198628007298 YchF GTPase; Region: YchF; cd01900 198628007299 G1 box; other site 198628007300 GTP/Mg2+ binding site [chemical binding]; other site 198628007301 Switch I region; other site 198628007302 G2 box; other site 198628007303 Switch II region; other site 198628007304 G3 box; other site 198628007305 G4 box; other site 198628007306 G5 box; other site 198628007307 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 198628007308 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 198628007309 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 198628007310 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 198628007311 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 198628007312 ATP binding site [chemical binding]; other site 198628007313 Mg++ binding site [ion binding]; other site 198628007314 motif III; other site 198628007315 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 198628007316 nucleotide binding region [chemical binding]; other site 198628007317 ATP-binding site [chemical binding]; other site 198628007318 RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501 198628007319 putative RNA binding site [nucleotide binding]; other site 198628007320 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 198628007321 binding surface 198628007322 TPR motif; other site 198628007323 Tetratricopeptide repeat; Region: TPR_16; pfam13432 198628007324 RNA polymerase sigma factor, SigM family; Region: SigM_subfam; TIGR02950 198628007325 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 198628007326 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 198628007327 DNA binding residues [nucleotide binding] 198628007328 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 198628007329 YceI-like domain; Region: YceI; pfam04264 198628007330 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 198628007331 heme-binding site [chemical binding]; other site 198628007332 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 198628007333 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 198628007334 metal binding site [ion binding]; metal-binding site 198628007335 active site 198628007336 I-site; other site 198628007337 exonuclease V subunit alpha; Provisional; Region: recD; PRK10875 198628007338 AAA domain; Region: AAA_30; pfam13604 198628007339 Family description; Region: UvrD_C_2; pfam13538 198628007340 exonuclease V subunit beta; Provisional; Region: recB; PRK10876 198628007341 Part of AAA domain; Region: AAA_19; pfam13245 198628007342 Family description; Region: UvrD_C_2; pfam13538 198628007343 exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450 198628007344 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 198628007345 Tir chaperone protein (CesT) family; Region: CesT; pfam05932 198628007346 Pathogenicity factor; Region: AvrE; pfam11725 198628007347 Pectate lyase; Region: Pectate_lyase; pfam03211 198628007348 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 198628007349 C factor cell-cell signaling protein; Provisional; Region: PRK09009 198628007350 NAD(P) binding site [chemical binding]; other site 198628007351 active site 198628007352 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 198628007353 putative addiction module antidote protein, CC2985 family; Region: antidote_CC2985; TIGR02606 198628007354 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 198628007355 DNA binding site [nucleotide binding] 198628007356 active site 198628007357 Int/Topo IB signature motif; other site 198628007358 Toxin SymE, type I toxin-antitoxin system; Region: SymE_toxin; pfam08845 198628007359 haemagglutination activity domain; Region: Haemagg_act; pfam05860 198628007360 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 198628007361 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 198628007362 Pre-toxin domain with VENN motif; Region: PT-VENN; pfam04829 198628007363 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 198628007364 hydroxyglutarate oxidase; Provisional; Region: PRK11728 198628007365 SpoVR family protein; Provisional; Region: PRK11767 198628007366 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 198628007367 fatty acid metabolism regulator; Provisional; Region: PRK04984 198628007368 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 198628007369 DNA-binding site [nucleotide binding]; DNA binding site 198628007370 FadR C-terminal domain; Region: FadR_C; pfam07840 198628007371 Bacterial Na+/H+ antiporter B (NhaB); Region: NhaB; cl17323 198628007372 disulfide bond formation protein B; Provisional; Region: PRK01749 198628007373 hypothetical protein; Provisional; Region: PRK05170 198628007374 hypothetical protein; Provisional; Region: PRK10691 198628007375 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 198628007376 YcgL domain; Region: YcgL; cl01189 198628007377 septum formation inhibitor; Reviewed; Region: minC; PRK03511 198628007378 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 198628007379 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 198628007380 cell division inhibitor MinD; Provisional; Region: PRK10818 198628007381 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 198628007382 Switch I; other site 198628007383 Switch II; other site 198628007384 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 198628007385 ribonuclease D; Provisional; Region: PRK10829 198628007386 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 198628007387 catalytic site [active] 198628007388 putative active site [active] 198628007389 putative substrate binding site [chemical binding]; other site 198628007390 HRDC domain; Region: HRDC; pfam00570 198628007391 single nucleotide deletion split fadD into two open reading frames, fadD_1 and fadD_2 198628007392 Starvation-inducible outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: Slp; COG3065 198628007393 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 198628007394 Glycoprotease family; Region: Peptidase_M22; pfam00814 198628007395 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 198628007396 DEAD/DEAH box helicase; Region: DEAD; pfam00270 198628007397 DEAD_2; Region: DEAD_2; pfam06733 198628007398 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 198628007399 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 198628007400 homotrimer interaction site [polypeptide binding]; other site 198628007401 putative active site [active] 198628007402 hypothetical protein; Provisional; Region: PRK05114 198628007403 aminodeoxychorismate synthase subunit I; Provisional; Region: pabB; PRK15465 198628007404 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 198628007405 chorismate binding enzyme; Region: Chorismate_bind; cl10555 198628007406 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 198628007407 putative active site [active] 198628007408 putative CoA binding site [chemical binding]; other site 198628007409 nudix motif; other site 198628007410 metal binding site [ion binding]; metal-binding site 198628007411 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 198628007412 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 198628007413 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 198628007414 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 198628007415 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 198628007416 dimer interface [polypeptide binding]; other site 198628007417 putative CheW interface [polypeptide binding]; other site 198628007418 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 198628007419 FOG: CBS domain [General function prediction only]; Region: COG0517 198628007420 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 198628007421 Transporter associated domain; Region: CorC_HlyC; smart01091 198628007422 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 198628007423 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 198628007424 active pocket/dimerization site; other site 198628007425 active site 198628007426 phosphorylation site [posttranslational modification] 198628007427 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 198628007428 active site 198628007429 phosphorylation site [posttranslational modification] 198628007430 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 198628007431 PTS system mannose-specific transporter subunit IID; Provisional; Region: PRK11103 198628007432 hypothetical protein; Provisional; Region: PRK02913 198628007433 hypothetical protein; Provisional; Region: PRK11469 198628007434 Domain of unknown function DUF; Region: DUF204; pfam02659 198628007435 Domain of unknown function DUF; Region: DUF204; pfam02659 198628007436 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 198628007437 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 198628007438 S-adenosylmethionine binding site [chemical binding]; other site 198628007439 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 198628007440 DNA-binding site [nucleotide binding]; DNA binding site 198628007441 RNA-binding motif; other site 198628007442 Fructosamine kinase; Region: Fructosamin_kin; pfam03881 198628007443 Phosphotransferase enzyme family; Region: APH; pfam01636 198628007444 YniB-like protein; Region: YniB; pfam14002 198628007445 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 198628007446 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 198628007447 2-deoxy-D-gluconate 3-dehydrogenase; Validated; Region: PRK08993 198628007448 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 198628007449 NADP binding site [chemical binding]; other site 198628007450 homodimer interface [polypeptide binding]; other site 198628007451 active site 198628007452 Periplasmic pectate lyase; Region: Pectate_lyase_2; pfam06917 198628007453 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198628007454 dimer interface [polypeptide binding]; other site 198628007455 conserved gate region; other site 198628007456 putative PBP binding loops; other site 198628007457 ABC-ATPase subunit interface; other site 198628007458 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 198628007459 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198628007460 dimer interface [polypeptide binding]; other site 198628007461 conserved gate region; other site 198628007462 putative PBP binding loops; other site 198628007463 ABC-ATPase subunit interface; other site 198628007464 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 198628007465 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 198628007466 Walker A/P-loop; other site 198628007467 ATP binding site [chemical binding]; other site 198628007468 Q-loop/lid; other site 198628007469 ABC transporter signature motif; other site 198628007470 Walker B; other site 198628007471 D-loop; other site 198628007472 H-loop/switch region; other site 198628007473 TOBE domain; Region: TOBE_2; pfam08402 198628007474 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 198628007475 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 198628007476 Oligogalacturonate-specific porin protein (KdgM); Region: KdgM; pfam06178 198628007477 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 198628007478 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 198628007479 inner membrane protein; Provisional; Region: PRK11648 198628007480 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 198628007481 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 198628007482 DNA-binding transcriptional activator OsmE; Provisional; Region: PRK11251 198628007483 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 198628007484 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 198628007485 homodimer interface [polypeptide binding]; other site 198628007486 NAD binding pocket [chemical binding]; other site 198628007487 ATP binding pocket [chemical binding]; other site 198628007488 Mg binding site [ion binding]; other site 198628007489 active-site loop [active] 198628007490 aromatic amino acid exporter; Provisional; Region: PRK11689 198628007491 Nitrous oxide-stimulated promoter; Region: YgbA_NO; pfam11756 198628007492 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 198628007493 IHF dimer interface [polypeptide binding]; other site 198628007494 IHF - DNA interface [nucleotide binding]; other site 198628007495 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 198628007496 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 198628007497 putative tRNA-binding site [nucleotide binding]; other site 198628007498 B3/4 domain; Region: B3_4; pfam03483 198628007499 tRNA synthetase B5 domain; Region: B5; smart00874 198628007500 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 198628007501 dimer interface [polypeptide binding]; other site 198628007502 motif 1; other site 198628007503 motif 3; other site 198628007504 motif 2; other site 198628007505 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 198628007506 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 198628007507 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 198628007508 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 198628007509 dimer interface [polypeptide binding]; other site 198628007510 motif 1; other site 198628007511 active site 198628007512 motif 2; other site 198628007513 motif 3; other site 198628007514 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 198628007515 23S rRNA binding site [nucleotide binding]; other site 198628007516 L21 binding site [polypeptide binding]; other site 198628007517 L13 binding site [polypeptide binding]; other site 198628007518 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 198628007519 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 198628007520 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 198628007521 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 198628007522 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 198628007523 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 198628007524 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 198628007525 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 198628007526 active site 198628007527 dimer interface [polypeptide binding]; other site 198628007528 motif 1; other site 198628007529 motif 2; other site 198628007530 motif 3; other site 198628007531 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 198628007532 anticodon binding site; other site 198628007533 YebO-like protein; Region: YebO; pfam13974 198628007534 DNA-binding transcriptional regulator KdgR; Provisional; Region: PRK15090 198628007535 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 198628007536 dimerization interface [polypeptide binding]; other site 198628007537 putative Zn2+ binding site [ion binding]; other site 198628007538 putative DNA binding site [nucleotide binding]; other site 198628007539 Bacterial transcriptional regulator; Region: IclR; pfam01614 198628007540 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 198628007541 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 198628007542 Transposase IS200 like; Region: Y1_Tnp; pfam01797 198628007543 heat shock protein HtpX; Provisional; Region: PRK05457 198628007544 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 198628007545 GAF domain; Region: GAF; pfam01590 198628007546 PAS domain S-box; Region: sensory_box; TIGR00229 198628007547 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 198628007548 putative active site [active] 198628007549 heme pocket [chemical binding]; other site 198628007550 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 198628007551 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 198628007552 metal binding site [ion binding]; metal-binding site 198628007553 active site 198628007554 I-site; other site 198628007555 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 198628007556 isocitrate dehydrogenase; Validated; Region: PRK07362 198628007557 isocitrate dehydrogenase; Reviewed; Region: PRK07006 198628007558 23S rRNA pseudouridine synthase E; Provisional; Region: PRK11394 198628007559 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 198628007560 active site 198628007561 Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675 198628007562 nudix motif; other site 198628007563 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 198628007564 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 198628007565 putative lysogenization regulator; Reviewed; Region: PRK00218 198628007566 adenylosuccinate lyase; Provisional; Region: PRK09285 198628007567 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 198628007568 tetramer interface [polypeptide binding]; other site 198628007569 active site 198628007570 DNA-binding transcriptional regulator PhoP; Provisional; Region: PRK10816 198628007571 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 198628007572 active site 198628007573 phosphorylation site [posttranslational modification] 198628007574 intermolecular recognition site; other site 198628007575 dimerization interface [polypeptide binding]; other site 198628007576 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 198628007577 DNA binding site [nucleotide binding] 198628007578 sensor protein PhoQ; Provisional; Region: PRK10815 198628007579 PhoQ Sensor; Region: PhoQ_Sensor; pfam08918 198628007580 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 198628007581 dimer interface [polypeptide binding]; other site 198628007582 phosphorylation site [posttranslational modification] 198628007583 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 198628007584 ATP binding site [chemical binding]; other site 198628007585 Mg2+ binding site [ion binding]; other site 198628007586 G-X-G motif; other site 198628007587 Uncharacterized conserved protein [Function unknown]; Region: COG2850 198628007588 Di- and tripeptidases [Amino acid transport and metabolism]; Region: PepD; COG2195 198628007589 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 198628007590 metal binding site [ion binding]; metal-binding site 198628007591 dimer interface [polypeptide binding]; other site 198628007592 FeoC like transcriptional regulator; Region: FeoC; pfam09012 198628007593 ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554 198628007594 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 198628007595 G1 box; other site 198628007596 GTP/Mg2+ binding site [chemical binding]; other site 198628007597 Switch I region; other site 198628007598 G2 box; other site 198628007599 G3 box; other site 198628007600 Switch II region; other site 198628007601 G4 box; other site 198628007602 G5 box; other site 198628007603 Nucleoside recognition; Region: Gate; pfam07670 198628007604 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 198628007605 Nucleoside recognition; Region: Gate; pfam07670 198628007606 FeoA domain; Region: FeoA; pfam04023 198628007607 FeoA domain; Region: FeoA; pfam04023 198628007608 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 198628007609 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 198628007610 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 198628007611 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 198628007612 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 198628007613 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 198628007614 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 198628007615 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 198628007616 Cupin domain; Region: Cupin_2; cl17218 198628007617 HrpZ; Region: Hairpins; pfam04877 198628007618 Type II secretory pathway, component PulD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulD; COG1450 198628007619 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 198628007620 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 198628007621 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 198628007622 conjugal transfer protein TraK; Provisional; Region: PRK13736; cl05878 198628007623 HrpF protein; Region: HrpF; pfam06266 198628007624 Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448 198628007625 Transglycosylase SLT domain; Region: SLT_2; pfam13406 198628007626 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 198628007627 N-acetyl-D-glucosamine binding site [chemical binding]; other site 198628007628 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 198628007629 HrpE/YscL/FliH and V-type ATPase subunit E; Region: HrpE; pfam06188 198628007630 type III secretion apparatus lipoprotein, YscJ/HrcJ family; Region: III_secr_YscJ; TIGR02544 198628007631 Type III secretion needle MxiH like; Region: MxiH; pfam09392 198628007632 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 198628007633 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 198628007634 Walker A motif; other site 198628007635 ATP binding site [chemical binding]; other site 198628007636 Walker B motif; other site 198628007637 arginine finger; other site 198628007638 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 198628007639 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 198628007640 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 198628007641 active site 198628007642 phosphorylation site [posttranslational modification] 198628007643 intermolecular recognition site; other site 198628007644 dimerization interface [polypeptide binding]; other site 198628007645 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 198628007646 DNA binding residues [nucleotide binding] 198628007647 dimerization interface [polypeptide binding]; other site 198628007648 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 198628007649 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 198628007650 putative active site [active] 198628007651 heme pocket [chemical binding]; other site 198628007652 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 198628007653 Histidine kinase; Region: HisKA_3; pfam07730 198628007654 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 198628007655 ATP binding site [chemical binding]; other site 198628007656 Mg2+ binding site [ion binding]; other site 198628007657 G-X-G motif; other site 198628007658 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 198628007659 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 198628007660 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 198628007661 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 198628007662 DNA binding residues [nucleotide binding] 198628007663 HrpJ-like domain; Region: HrpJ; cl15454 198628007664 TyeA; Region: TyeA; cl07611 198628007665 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980 198628007666 FHIPEP family; Region: FHIPEP; pfam00771 198628007667 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062 198628007668 phosphopeptide binding site; other site 198628007669 type III secretion apparatus H+-transporting two-sector ATPase; Region: III_secr_ATP; TIGR02546 198628007670 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 198628007671 Walker A motif; other site 198628007672 ATP binding site [chemical binding]; other site 198628007673 Walker B motif; other site 198628007674 Flagellar hook-length control protein FliK; Region: Flg_hook; cl17777 198628007675 type III secretion system apparatus protein YscQ/HrcQ; Region: SpaO_YscQ; TIGR02551 198628007676 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 198628007677 type III secretion system protein YscR; Provisional; Region: PRK12797 198628007678 Bacterial export proteins, family 3; Region: Bac_export_3; cl00867 198628007679 Bacterial export proteins, family 1; Region: Bac_export_1; pfam01311 198628007680 type III secretion protein, YscU/HrpY family; Region: FlhB_rel_III; TIGR01404 198628007681 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 198628007682 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 198628007683 OsmC-like protein; Region: OsmC; cl00767 198628007684 microcin B17 transporter; Reviewed; Region: PRK11098 198628007685 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 198628007686 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 198628007687 dimerization interface [polypeptide binding]; other site 198628007688 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 198628007689 dimer interface [polypeptide binding]; other site 198628007690 putative CheW interface [polypeptide binding]; other site 198628007691 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 198628007692 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 198628007693 dimerization interface [polypeptide binding]; other site 198628007694 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 198628007695 dimer interface [polypeptide binding]; other site 198628007696 putative CheW interface [polypeptide binding]; other site 198628007697 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 198628007698 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 198628007699 substrate binding pocket [chemical binding]; other site 198628007700 membrane-bound complex binding site; other site 198628007701 hinge residues; other site 198628007702 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 198628007703 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198628007704 dimer interface [polypeptide binding]; other site 198628007705 conserved gate region; other site 198628007706 putative PBP binding loops; other site 198628007707 ABC-ATPase subunit interface; other site 198628007708 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 198628007709 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198628007710 dimer interface [polypeptide binding]; other site 198628007711 conserved gate region; other site 198628007712 putative PBP binding loops; other site 198628007713 ABC-ATPase subunit interface; other site 198628007714 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 198628007715 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 198628007716 Walker A/P-loop; other site 198628007717 ATP binding site [chemical binding]; other site 198628007718 Q-loop/lid; other site 198628007719 ABC transporter signature motif; other site 198628007720 Walker B; other site 198628007721 D-loop; other site 198628007722 H-loop/switch region; other site 198628007723 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 198628007724 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 198628007725 homodimer interface [polypeptide binding]; other site 198628007726 substrate-cofactor binding pocket; other site 198628007727 pyridoxal 5'-phosphate binding site [chemical binding]; other site 198628007728 catalytic residue [active] 198628007729 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 198628007730 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 198628007731 active site 198628007732 motif I; other site 198628007733 motif II; other site 198628007734 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 198628007735 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198628007736 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 198628007737 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 198628007738 active site 198628007739 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 198628007740 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 198628007741 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 198628007742 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 198628007743 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 198628007744 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198628007745 dimer interface [polypeptide binding]; other site 198628007746 conserved gate region; other site 198628007747 putative PBP binding loops; other site 198628007748 ABC-ATPase subunit interface; other site 198628007749 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198628007750 dimer interface [polypeptide binding]; other site 198628007751 conserved gate region; other site 198628007752 putative PBP binding loops; other site 198628007753 ABC-ATPase subunit interface; other site 198628007754 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 198628007755 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 198628007756 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 198628007757 tetramerization interface [polypeptide binding]; other site 198628007758 NAD(P) binding site [chemical binding]; other site 198628007759 catalytic residues [active] 198628007760 4-aminobutyrate aminotransferase; Provisional; Region: PRK06777 198628007761 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 198628007762 inhibitor-cofactor binding pocket; inhibition site 198628007763 pyridoxal 5'-phosphate binding site [chemical binding]; other site 198628007764 catalytic residue [active] 198628007765 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 198628007766 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 198628007767 DNA-binding site [nucleotide binding]; DNA binding site 198628007768 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 198628007769 pyridoxal 5'-phosphate binding site [chemical binding]; other site 198628007770 homodimer interface [polypeptide binding]; other site 198628007771 catalytic residue [active] 198628007772 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 198628007773 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 198628007774 Walker A/P-loop; other site 198628007775 ATP binding site [chemical binding]; other site 198628007776 Q-loop/lid; other site 198628007777 ABC transporter signature motif; other site 198628007778 Walker B; other site 198628007779 D-loop; other site 198628007780 H-loop/switch region; other site 198628007781 TOBE domain; Region: TOBE_2; pfam08402 198628007782 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 198628007783 Domain of unknown function (DUF1852); Region: DUF1852; pfam08908 198628007784 methionine synthase; Provisional; Region: PRK01207 198628007785 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 198628007786 substrate binding site [chemical binding]; other site 198628007787 THF binding site; other site 198628007788 zinc-binding site [ion binding]; other site 198628007789 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 198628007790 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 198628007791 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 198628007792 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 198628007793 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 198628007794 putative C-terminal domain interface [polypeptide binding]; other site 198628007795 putative GSH binding site (G-site) [chemical binding]; other site 198628007796 putative dimer interface [polypeptide binding]; other site 198628007797 C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180 198628007798 putative N-terminal domain interface [polypeptide binding]; other site 198628007799 putative dimer interface [polypeptide binding]; other site 198628007800 putative substrate binding pocket (H-site) [chemical binding]; other site 198628007801 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 198628007802 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 198628007803 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 198628007804 P-loop; other site 198628007805 Magnesium ion binding site [ion binding]; other site 198628007806 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 198628007807 Magnesium ion binding site [ion binding]; other site 198628007808 Prophage maintenance system killer protein [General function prediction only]; Region: Doc; COG3654 198628007809 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 198628007810 putative transposase OrfB; Reviewed; Region: PHA02517 198628007811 HTH-like domain; Region: HTH_21; pfam13276 198628007812 Integrase core domain; Region: rve; pfam00665 198628007813 Integrase core domain; Region: rve_2; pfam13333 198628007814 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198628007815 Helix-turn-helix domain; Region: HTH_28; pfam13518 198628007816 Helix-turn-helix domain; Region: HTH_28; pfam13518 198628007817 putative alcohol dehydrogenase; Provisional; Region: PRK09860 198628007818 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 198628007819 dimer interface [polypeptide binding]; other site 198628007820 active site 198628007821 metal binding site [ion binding]; metal-binding site 198628007822 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_23; cd04682 198628007823 nudix motif; other site 198628007824 respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351 198628007825 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 198628007826 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 198628007827 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 198628007828 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 198628007829 [4Fe-4S] binding site [ion binding]; other site 198628007830 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 198628007831 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 198628007832 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 198628007833 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 198628007834 molybdopterin cofactor binding site; other site 198628007835 transcriptional regulator; Provisional; Region: PRK10632 198628007836 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 198628007837 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 198628007838 putative effector binding pocket; other site 198628007839 dimerization interface [polypeptide binding]; other site 198628007840 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 198628007841 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 198628007842 nitrate/nitrite sensor protein NarX; Provisional; Region: PRK10600 198628007843 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 198628007844 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 198628007845 dimerization interface [polypeptide binding]; other site 198628007846 Histidine kinase; Region: HisKA_3; pfam07730 198628007847 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 198628007848 ATP binding site [chemical binding]; other site 198628007849 Mg2+ binding site [ion binding]; other site 198628007850 G-X-G motif; other site 198628007851 transcriptional regulator NarL; Provisional; Region: PRK10651 198628007852 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 198628007853 active site 198628007854 phosphorylation site [posttranslational modification] 198628007855 intermolecular recognition site; other site 198628007856 dimerization interface [polypeptide binding]; other site 198628007857 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 198628007858 DNA binding residues [nucleotide binding] 198628007859 dimerization interface [polypeptide binding]; other site 198628007860 Acyltransferase family; Region: Acyl_transf_3; pfam01757 198628007861 Protein of unknown function, DUF481; Region: DUF481; pfam04338 198628007862 carboxy-terminal protease; Provisional; Region: PRK11186 198628007863 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 198628007864 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 198628007865 protein binding site [polypeptide binding]; other site 198628007866 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 198628007867 Catalytic dyad [active] 198628007868 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 198628007869 ProP expression regulator; Provisional; Region: PRK04950 198628007870 ProQ/FINO family; Region: ProQ; pfam04352 198628007871 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 198628007872 Uncharacterized paraquat-inducible protein A [Function unknown]; Region: PqiA; COG2995 198628007873 Paraquat-inducible protein A; Region: PqiA; pfam04403 198628007874 Paraquat-inducible protein A; Region: PqiA; pfam04403 198628007875 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 198628007876 mce related protein; Region: MCE; pfam02470 198628007877 mce related protein; Region: MCE; pfam02470 198628007878 mce related protein; Region: MCE; pfam02470 198628007879 mce related protein; Region: MCE; pfam02470 198628007880 mce related protein; Region: MCE; pfam02470 198628007881 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 198628007882 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 198628007883 S-adenosylmethionine binding site [chemical binding]; other site 198628007884 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 198628007885 Protein of unknown function (DUF1482); Region: DUF1482; pfam07358 198628007886 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 198628007887 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 198628007888 dimerization interface [polypeptide binding]; other site 198628007889 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 198628007890 dimer interface [polypeptide binding]; other site 198628007891 putative CheW interface [polypeptide binding]; other site 198628007892 Bacteriophage CI repressor helix-turn-helix domain; Region: Phage_CI_repr; pfam07022 198628007893 Bacteriophage CI repressor helix-turn-helix domain; Region: Phage_CI_repr; pfam07022 198628007894 Protein of unknown function (DUF2732); Region: DUF2732; pfam10809 198628007895 DksA-like zinc finger domain containing protein; Region: PHA00080 198628007896 Bacteriophage replication gene A protein (GPA); Region: Phage_GPA; pfam05840 198628007897 Phage Tail Protein X; Region: Phage_tail_X; pfam05489 198628007898 P2 phage tail completion protein R (GpR); Region: P2_Phage_GpR; pfam06891 198628007899 phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644 198628007900 Phage P2 baseplate assembly protein gpV [General function prediction only]; Region: gpV; COG4540 198628007901 baseplate wedge subunit; Provisional; Region: W; PHA02516 198628007902 baseplate assembly protein; Provisional; Region: J; PHA02568 198628007903 Bacteriophage P2-related tail formation protein [General function prediction only]; Region: gpI; COG4385 198628007904 Phage tail-collar fibre protein; Region: DUF3751; pfam12571 198628007905 Phage Tail Collar Domain; Region: Collar; pfam07484 198628007906 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 198628007907 SdiA-regulated; Region: SdiA-regulated; cd09971 198628007908 putative active site [active] 198628007909 benzoate transport; Region: 2A0115; TIGR00895 198628007910 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198628007911 putative substrate translocation pore; other site 198628007912 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198628007913 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 198628007914 Smr domain; Region: Smr; pfam01713 198628007915 multiple promoter invertase; Provisional; Region: mpi; PRK13413 198628007916 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 198628007917 catalytic residues [active] 198628007918 catalytic nucleophile [active] 198628007919 Presynaptic Site I dimer interface [polypeptide binding]; other site 198628007920 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 198628007921 Synaptic Flat tetramer interface [polypeptide binding]; other site 198628007922 Synaptic Site I dimer interface [polypeptide binding]; other site 198628007923 DNA binding site [nucleotide binding] 198628007924 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 198628007925 DNA-binding interface [nucleotide binding]; DNA binding site 198628007926 Phage Tail Collar Domain; Region: Collar; pfam07484 198628007927 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 198628007928 major tail sheath protein; Provisional; Region: FI; PHA02560 198628007929 major tail tube protein; Provisional; Region: FII; PHA02600 198628007930 Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109 198628007931 Phage P2 GpE; Region: Phage_P2_GpE; pfam06528 198628007932 Phage P2 GpU; Region: Phage_P2_GpU; pfam06995 198628007933 Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796 198628007934 guanine deaminase; Provisional; Region: PRK09228 198628007935 Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303 198628007936 active site 198628007937 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 198628007938 GAF domain; Region: GAF; pfam01590 198628007939 PAS domain S-box; Region: sensory_box; TIGR00229 198628007940 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 198628007941 putative active site [active] 198628007942 heme pocket [chemical binding]; other site 198628007943 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 198628007944 PAS domain; Region: PAS_9; pfam13426 198628007945 putative active site [active] 198628007946 heme pocket [chemical binding]; other site 198628007947 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 198628007948 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 198628007949 metal binding site [ion binding]; metal-binding site 198628007950 active site 198628007951 I-site; other site 198628007952 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 198628007953 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 198628007954 dimer interface [polypeptide binding]; other site 198628007955 ligand binding site [chemical binding]; other site 198628007956 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 198628007957 dimerization interface [polypeptide binding]; other site 198628007958 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 198628007959 dimer interface [polypeptide binding]; other site 198628007960 putative CheW interface [polypeptide binding]; other site 198628007961 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 198628007962 PAS domain; Region: PAS_9; pfam13426 198628007963 putative active site [active] 198628007964 heme pocket [chemical binding]; other site 198628007965 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 198628007966 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 198628007967 dimer interface [polypeptide binding]; other site 198628007968 putative CheW interface [polypeptide binding]; other site 198628007969 PrpA and PrpB, metallophosphatase domain; Region: MPP_PrpA_PrpB; cd07424 198628007970 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 198628007971 active site 198628007972 metal binding site [ion binding]; metal-binding site 198628007973 Putative ClC chloride channel. Clc proteins are putative halogen ion (Cl-, Br- and I-) transporters found in eubacteria. They belong to the ClC superfamily of halogen ion channels, which share a unique double-barreled architecture and voltage-dependent...; Region: ClC_like; cd01033 198628007974 putative ion selectivity filter; other site 198628007975 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 198628007976 putative pore gating glutamate residue; other site 198628007977 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 198628007978 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 198628007979 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 198628007980 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 198628007981 Walker A/P-loop; other site 198628007982 ATP binding site [chemical binding]; other site 198628007983 Q-loop/lid; other site 198628007984 ABC transporter signature motif; other site 198628007985 Walker B; other site 198628007986 D-loop; other site 198628007987 H-loop/switch region; other site 198628007988 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 198628007989 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 198628007990 Walker A/P-loop; other site 198628007991 ATP binding site [chemical binding]; other site 198628007992 Q-loop/lid; other site 198628007993 ABC transporter signature motif; other site 198628007994 Walker B; other site 198628007995 D-loop; other site 198628007996 H-loop/switch region; other site 198628007997 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 198628007998 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198628007999 dimer interface [polypeptide binding]; other site 198628008000 conserved gate region; other site 198628008001 ABC-ATPase subunit interface; other site 198628008002 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 198628008003 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198628008004 dimer interface [polypeptide binding]; other site 198628008005 conserved gate region; other site 198628008006 putative PBP binding loops; other site 198628008007 ABC-ATPase subunit interface; other site 198628008008 Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703 198628008009 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 198628008010 putative active site pocket [active] 198628008011 dimerization interface [polypeptide binding]; other site 198628008012 putative catalytic residue [active] 198628008013 calcium/sodium:proton antiporter; Provisional; Region: PRK10599 198628008014 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 198628008015 putative transporter; Provisional; Region: PRK11660 198628008016 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 198628008017 Sulfate transporter family; Region: Sulfate_transp; pfam00916 198628008018 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 198628008019 DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701 198628008020 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 198628008021 active site 198628008022 phosphorylation site [posttranslational modification] 198628008023 intermolecular recognition site; other site 198628008024 dimerization interface [polypeptide binding]; other site 198628008025 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 198628008026 DNA binding site [nucleotide binding] 198628008027 sensor protein RstB; Provisional; Region: PRK10604 198628008028 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 198628008029 dimerization interface [polypeptide binding]; other site 198628008030 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 198628008031 dimer interface [polypeptide binding]; other site 198628008032 phosphorylation site [posttranslational modification] 198628008033 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 198628008034 ATP binding site [chemical binding]; other site 198628008035 G-X-G motif; other site 198628008036 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 198628008037 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 198628008038 L-lactate permease; Region: Lactate_perm; cl00701 198628008039 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 198628008040 Cysteine-rich domain; Region: CCG; pfam02754 198628008041 Cysteine-rich domain; Region: CCG; pfam02754 198628008042 iron-sulfur cluster-binding protein; Region: TIGR00273 198628008043 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 198628008044 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 198628008045 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 198628008046 Uncharacterized conserved protein [Function unknown]; Region: COG1556 198628008047 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 198628008048 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 198628008049 ATP binding site [chemical binding]; other site 198628008050 putative Mg++ binding site [ion binding]; other site 198628008051 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 198628008052 nucleotide binding region [chemical binding]; other site 198628008053 ATP-binding site [chemical binding]; other site 198628008054 Helicase associated domain (HA2); Region: HA2; pfam04408 198628008055 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 198628008056 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 198628008057 azoreductase; Reviewed; Region: PRK00170 198628008058 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 198628008059 YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617 198628008060 hypothetical protein; Provisional; Region: PRK10695 198628008061 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 198628008062 PAS domain; Region: PAS_9; pfam13426 198628008063 putative active site [active] 198628008064 heme pocket [chemical binding]; other site 198628008065 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 198628008066 dimerization interface [polypeptide binding]; other site 198628008067 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 198628008068 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 198628008069 dimer interface [polypeptide binding]; other site 198628008070 putative CheW interface [polypeptide binding]; other site 198628008071 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 198628008072 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 198628008073 putative ligand binding site [chemical binding]; other site 198628008074 putative NAD binding site [chemical binding]; other site 198628008075 catalytic site [active] 198628008076 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 198628008077 Domain of unknown function (DUF333); Region: DUF333; pfam03891 198628008078 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 198628008079 dimerization interface [polypeptide binding]; other site 198628008080 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 198628008081 dimer interface [polypeptide binding]; other site 198628008082 putative CheW interface [polypeptide binding]; other site 198628008083 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 198628008084 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 198628008085 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 198628008086 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 198628008087 Ligand Binding Site [chemical binding]; other site 198628008088 Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833 198628008089 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 198628008090 Cl binding site [ion binding]; other site 198628008091 oligomer interface [polypeptide binding]; other site 198628008092 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 198628008093 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 198628008094 peptide binding site [polypeptide binding]; other site 198628008095 murein peptide amidase A; Provisional; Region: PRK10602 198628008096 active site 198628008097 Zn binding site [ion binding]; other site 198628008098 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 198628008099 dimer interface [polypeptide binding]; other site 198628008100 catalytic triad [active] 198628008101 peroxidatic and resolving cysteines [active] 198628008102 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198628008103 putative substrate translocation pore; other site 198628008104 Helix-turn-helix domain; Region: HTH_31; pfam13560 198628008105 salt bridge; other site 198628008106 non-specific DNA binding site [nucleotide binding]; other site 198628008107 sequence-specific DNA binding site [nucleotide binding]; other site 198628008108 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 198628008109 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 198628008110 active site 198628008111 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 198628008112 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 198628008113 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 198628008114 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 198628008115 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 198628008116 putative active site [active] 198628008117 putative FMN binding site [chemical binding]; other site 198628008118 putative substrate binding site [chemical binding]; other site 198628008119 putative catalytic residue [active] 198628008120 Transcriptional regulator [Transcription]; Region: LysR; COG0583 198628008121 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 198628008122 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 198628008123 putative effector binding pocket; other site 198628008124 putative dimerization interface [polypeptide binding]; other site 198628008125 DNA-binding transcriptional regulator TyrR; Provisional; Region: PRK10820 198628008126 N-terminal ACT domain of the TyrR protein; Region: ACT_TyrR; cd04877 198628008127 putative aromatic amino acid binding site; other site 198628008128 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 198628008129 putative active site [active] 198628008130 heme pocket [chemical binding]; other site 198628008131 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 198628008132 Walker A motif; other site 198628008133 ATP binding site [chemical binding]; other site 198628008134 Walker B motif; other site 198628008135 arginine finger; other site 198628008136 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 198628008137 hypothetical protein; Provisional; Region: PRK06446 198628008138 metal binding site [ion binding]; metal-binding site 198628008139 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 198628008140 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198628008141 putative substrate translocation pore; other site 198628008142 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198628008143 hypothetical protein; Provisional; Region: PRK05415 198628008144 Domain of unknown function (DUF697); Region: DUF697; cl12064 198628008145 Predicted ATPase [General function prediction only]; Region: COG3106 198628008146 DNA-binding transcriptional activator PspC; Provisional; Region: PRK10697 198628008147 phage shock protein C; Region: phageshock_pspC; TIGR02978 198628008148 phage shock protein B; Provisional; Region: pspB; PRK09458 198628008149 phage shock protein PspA; Provisional; Region: PRK10698 198628008150 phage shock protein operon transcriptional activator; Provisional; Region: pspF; PRK11608 198628008151 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 198628008152 Walker A motif; other site 198628008153 ATP binding site [chemical binding]; other site 198628008154 Walker B motif; other site 198628008155 arginine finger; other site 198628008156 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 198628008157 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 198628008158 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 198628008159 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 198628008160 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 198628008161 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 198628008162 peptide binding site [polypeptide binding]; other site 198628008163 antimicrobial peptide ABC transporter permease SapB; Provisional; Region: PRK15110 198628008164 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198628008165 dimer interface [polypeptide binding]; other site 198628008166 conserved gate region; other site 198628008167 putative PBP binding loops; other site 198628008168 ABC-ATPase subunit interface; other site 198628008169 antimicrobial peptide ABC transporter permease SapC; Provisional; Region: PRK15111 198628008170 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 198628008171 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198628008172 putative PBP binding loops; other site 198628008173 dimer interface [polypeptide binding]; other site 198628008174 ABC-ATPase subunit interface; other site 198628008175 antimicrobial peptide ABC transporter ATP-binding protein; Provisional; Region: PRK15093 198628008176 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 198628008177 Walker A/P-loop; other site 198628008178 ATP binding site [chemical binding]; other site 198628008179 Q-loop/lid; other site 198628008180 ABC transporter signature motif; other site 198628008181 Walker B; other site 198628008182 D-loop; other site 198628008183 H-loop/switch region; other site 198628008184 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 198628008185 antimicrobial peptide ABC system ATP-binding protein SapF; Provisional; Region: PRK15112 198628008186 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 198628008187 Walker A/P-loop; other site 198628008188 ATP binding site [chemical binding]; other site 198628008189 Q-loop/lid; other site 198628008190 ABC transporter signature motif; other site 198628008191 Walker B; other site 198628008192 D-loop; other site 198628008193 H-loop/switch region; other site 198628008194 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07984 198628008195 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 198628008196 NAD binding site [chemical binding]; other site 198628008197 homotetramer interface [polypeptide binding]; other site 198628008198 homodimer interface [polypeptide binding]; other site 198628008199 substrate binding site [chemical binding]; other site 198628008200 active site 198628008201 Transcriptional regulator [Transcription]; Region: LysR; COG0583 198628008202 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 198628008203 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 198628008204 dimerization interface [polypeptide binding]; other site 198628008205 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 198628008206 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 198628008207 putative molybdopterin cofactor binding site [chemical binding]; other site 198628008208 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 198628008209 putative molybdopterin cofactor binding site; other site 198628008210 Predicted membrane protein (DUF2335); Region: DUF2335; cl02210 198628008211 exoribonuclease II; Provisional; Region: PRK05054 198628008212 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 198628008213 RNB domain; Region: RNB; pfam00773 198628008214 S1 RNA binding domain; Region: S1; pfam00575 198628008215 RNA binding site [nucleotide binding]; other site 198628008216 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 198628008217 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 198628008218 active site 198628008219 catalytic tetrad [active] 198628008220 carbon starvation protein A; Provisional; Region: PRK15015 198628008221 Carbon starvation protein CstA; Region: CstA; pfam02554 198628008222 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 198628008223 2-keto-3-deoxygluconate transporter; Region: kdgT; TIGR00793 198628008224 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 198628008225 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 198628008226 intersubunit interface [polypeptide binding]; other site 198628008227 active site 198628008228 Zn2+ binding site [ion binding]; other site 198628008229 lipoprotein; Provisional; Region: PRK10540 198628008230 translation initiation factor Sui1; Validated; Region: PRK06824 198628008231 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 198628008232 putative rRNA binding site [nucleotide binding]; other site 198628008233 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 198628008234 active site 198628008235 dimer interface [polypeptide binding]; other site 198628008236 tetratricopeptide repeat protein; Provisional; Region: PRK11788 198628008237 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 198628008238 TPR motif; other site 198628008239 binding surface 198628008240 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 198628008241 binding surface 198628008242 TPR motif; other site 198628008243 Predicted membrane protein [Function unknown]; Region: COG3771 198628008244 phosphatidylglycerophosphatase B; Provisional; Region: PRK10699 198628008245 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 198628008246 active site 198628008247 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 198628008248 dimerization interface [polypeptide binding]; other site 198628008249 active site 198628008250 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 198628008251 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 198628008252 peptide binding site [polypeptide binding]; other site 198628008253 aconitate hydratase; Validated; Region: PRK09277 198628008254 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 198628008255 substrate binding site [chemical binding]; other site 198628008256 ligand binding site [chemical binding]; other site 198628008257 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 198628008258 substrate binding site [chemical binding]; other site 198628008259 glutathionine S-transferase; Provisional; Region: PRK10542 198628008260 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 198628008261 C-terminal domain interface [polypeptide binding]; other site 198628008262 GSH binding site (G-site) [chemical binding]; other site 198628008263 dimer interface [polypeptide binding]; other site 198628008264 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 198628008265 N-terminal domain interface [polypeptide binding]; other site 198628008266 dimer interface [polypeptide binding]; other site 198628008267 substrate binding pocket (H-site) [chemical binding]; other site 198628008268 pyridoxamine kinase; Validated; Region: PRK05756 198628008269 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 198628008270 dimer interface [polypeptide binding]; other site 198628008271 pyridoxal binding site [chemical binding]; other site 198628008272 ATP binding site [chemical binding]; other site 198628008273 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 198628008274 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 198628008275 active site 198628008276 HIGH motif; other site 198628008277 dimer interface [polypeptide binding]; other site 198628008278 KMSKS motif; other site 198628008279 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 198628008280 RNA binding surface [nucleotide binding]; other site 198628008282 lysozyme inhibitor; Provisional; Region: PRK11372 198628008283 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 198628008284 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 198628008285 Outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: SlyB; COG3133 198628008286 transcriptional regulator SlyA; Provisional; Region: PRK03573 198628008287 MarR family; Region: MarR; pfam01047 198628008288 Predicted Fe-S protein [General function prediction only]; Region: COG3313 198628008289 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 198628008290 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 198628008291 dimer interface [polypeptide binding]; other site 198628008292 active site 198628008293 metal binding site [ion binding]; metal-binding site 198628008294 glutathione binding site [chemical binding]; other site 198628008295 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 198628008296 DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134 198628008297 dimer interface [polypeptide binding]; other site 198628008298 catalytic site [active] 198628008299 putative active site [active] 198628008300 putative substrate binding site [chemical binding]; other site 198628008301 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 198628008302 putative GSH binding site [chemical binding]; other site 198628008303 catalytic residues [active] 198628008304 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 198628008305 NlpC/P60 family; Region: NLPC_P60; pfam00877 198628008306 DNA-binding transcriptional repressor PurR; Provisional; Region: PRK10703 198628008307 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 198628008308 DNA binding site [nucleotide binding] 198628008309 domain linker motif; other site 198628008310 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 198628008311 dimerization interface [polypeptide binding]; other site 198628008312 ligand binding site [chemical binding]; other site 198628008313 cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705 198628008314 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 198628008315 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 198628008316 S-adenosylmethionine binding site [chemical binding]; other site 198628008317 riboflavin synthase subunit alpha; Provisional; Region: PRK13020 198628008318 Lumazine binding domain; Region: Lum_binding; pfam00677 198628008319 Lumazine binding domain; Region: Lum_binding; pfam00677 198628008320 a single nucleotide deletion after codon 301 relative to mdtK in Erwinia carotovora SCRI1043 (ASAP:ABL-0062183) results in a frameshift leading to termination after codon 356 198628008321 Bacterial chaperone lipoprotein (PulS_OutS); Region: PulS_OutS; cl09898 198628008322 Pectate lyase; Region: Pec_lyase_C; cl01593 198628008323 Type II secretion system (T2SS), protein M; Region: T2SM; cl01222 198628008324 Type II secretion system (T2SS), protein L; Region: T2SL; pfam05134 198628008325 type II secretion system protein L; Region: typeII_sec_gspL; TIGR01709 198628008326 Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934 198628008327 Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612 198628008328 type II secretion system protein I; Region: gspI; TIGR01707 198628008329 Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501 198628008330 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 198628008331 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 198628008332 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 198628008333 type II secretion system protein F; Region: GspF; TIGR02120 198628008334 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 198628008335 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 198628008336 type II secretion system protein E; Region: type_II_gspE; TIGR02533 198628008337 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 198628008338 Walker A motif; other site 198628008339 ATP binding site [chemical binding]; other site 198628008340 Walker B motif; other site 198628008341 type II secretion system protein D; Region: type_II_gspD; TIGR02517 198628008342 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 198628008343 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 198628008344 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 198628008345 Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356 198628008346 Zinc finger C-x8-C-x5-C-x3-H type (and similar); Region: zf-CCCH; cl11592 198628008347 N-terminal Early set domain associated with the catalytic domain of putative esterases; Region: E_set_Esterase_like_N; cd11294 198628008348 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 198628008349 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 198628008350 Maltoporin periplasmic N-terminal extension; Region: Sugarporin_N; pfam11471 198628008351 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 198628008352 trimer interface; other site 198628008353 sugar binding site [chemical binding]; other site 198628008354 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 198628008355 beta-galactosidase; Region: BGL; TIGR03356 198628008356 PTS system beta-glucoside-specific transporter subunits IIABC; Provisional; Region: PRK09824 198628008357 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 198628008358 active site turn [active] 198628008359 phosphorylation site [posttranslational modification] 198628008360 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 198628008361 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 198628008362 HPr interaction site; other site 198628008363 glycerol kinase (GK) interaction site [polypeptide binding]; other site 198628008364 active site 198628008365 phosphorylation site [posttranslational modification] 198628008366 transcriptional antiterminator BglG; Provisional; Region: PRK09772 198628008367 CAT RNA binding domain; Region: CAT_RBD; pfam03123 198628008368 PRD domain; Region: PRD; pfam00874 198628008369 PRD domain; Region: PRD; pfam00874 198628008370 pyruvate kinase; Provisional; Region: PRK09206 198628008371 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 198628008372 domain interfaces; other site 198628008373 active site 198628008374 murein lipoprotein; Provisional; Region: PRK15396 198628008375 L,D-transpeptidase; Provisional; Region: PRK10190 198628008376 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 198628008377 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 198628008378 cysteine desufuration protein SufE; Provisional; Region: PRK09296 198628008379 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 198628008380 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 198628008381 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 198628008382 catalytic residue [active] 198628008383 cysteine desulfurase activator complex subunit SufD; Provisional; Region: PRK10948 198628008384 FeS assembly protein SufD; Region: sufD; TIGR01981 198628008385 cysteine desulfurase ATPase component; Reviewed; Region: sufC; PRK09580 198628008386 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 198628008387 Walker A/P-loop; other site 198628008388 ATP binding site [chemical binding]; other site 198628008389 Q-loop/lid; other site 198628008390 ABC transporter signature motif; other site 198628008391 Walker B; other site 198628008392 D-loop; other site 198628008393 H-loop/switch region; other site 198628008394 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 198628008395 putative ABC transporter; Region: ycf24; CHL00085 198628008396 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 198628008397 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 198628008398 CoenzymeA binding site [chemical binding]; other site 198628008399 subunit interaction site [polypeptide binding]; other site 198628008400 PHB binding site; other site 198628008401 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 198628008402 FAD binding domain; Region: FAD_binding_4; pfam01565 198628008403 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 198628008404 putative inner membrane protein; Provisional; Region: PRK10983 198628008405 Domain of unknown function DUF20; Region: UPF0118; pfam01594 198628008406 phosphoenolpyruvate synthase; Validated; Region: PRK06464 198628008407 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 198628008408 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 198628008409 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 198628008410 PEP synthetase regulatory protein; Provisional; Region: PRK05339 198628008411 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12756 198628008412 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 198628008413 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009 198628008414 Protein of unknown function (DUF330); Region: DUF330; pfam03886 198628008415 paraquat-inducible protein B; Provisional; Region: PRK10807 198628008416 mce related protein; Region: MCE; pfam02470 198628008417 mce related protein; Region: MCE; pfam02470 198628008418 mce related protein; Region: MCE; pfam02470 198628008419 paraquat-inducible membrane protein A; Provisional; Region: PRK15103 198628008420 Paraquat-inducible protein A; Region: PqiA; pfam04403 198628008421 Paraquat-inducible protein A; Region: PqiA; pfam04403 198628008422 ABC transporter ATPase component; Reviewed; Region: PRK11147 198628008423 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 198628008424 Walker A/P-loop; other site 198628008425 ATP binding site [chemical binding]; other site 198628008426 Q-loop/lid; other site 198628008427 ABC transporter signature motif; other site 198628008428 Walker B; other site 198628008429 D-loop; other site 198628008430 H-loop/switch region; other site 198628008431 ABC transporter; Region: ABC_tran_2; pfam12848 198628008432 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 198628008433 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 198628008434 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 198628008435 Putative RNA methylase family UPF0020; Region: UPF0020; pfam01170 198628008436 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 198628008437 S-adenosylmethionine binding site [chemical binding]; other site 198628008438 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 198628008439 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 198628008440 MOSC domain; Region: MOSC; pfam03473 198628008441 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 198628008442 catalytic loop [active] 198628008443 iron binding site [ion binding]; other site 198628008444 Protein of unknown function (DUF1379); Region: DUF1379; pfam07126 198628008445 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 198628008446 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 198628008447 quinone interaction residues [chemical binding]; other site 198628008448 active site 198628008449 catalytic residues [active] 198628008450 FMN binding site [chemical binding]; other site 198628008451 substrate binding site [chemical binding]; other site 198628008452 NAD(P)H-dependent FMN reductase; Provisional; Region: PRK10569 198628008453 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 198628008454 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 198628008455 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 198628008456 substrate binding pocket [chemical binding]; other site 198628008457 membrane-bound complex binding site; other site 198628008458 hinge residues; other site 198628008459 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 198628008460 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 198628008461 active site 198628008462 dimer interface [polypeptide binding]; other site 198628008463 non-prolyl cis peptide bond; other site 198628008464 insertion regions; other site 198628008465 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 198628008466 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198628008467 dimer interface [polypeptide binding]; other site 198628008468 conserved gate region; other site 198628008469 putative PBP binding loops; other site 198628008470 ABC-ATPase subunit interface; other site 198628008471 aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247 198628008472 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 198628008473 Walker A/P-loop; other site 198628008474 ATP binding site [chemical binding]; other site 198628008475 Q-loop/lid; other site 198628008476 ABC transporter signature motif; other site 198628008477 Walker B; other site 198628008478 D-loop; other site 198628008479 H-loop/switch region; other site 198628008480 aminopeptidase N; Provisional; Region: pepN; PRK14015 198628008481 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 198628008482 active site 198628008483 Zn binding site [ion binding]; other site 198628008484 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 198628008485 Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401 198628008486 active site 198628008487 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 198628008488 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 198628008489 putative dimer interface [polypeptide binding]; other site 198628008490 putative anticodon binding site; other site 198628008491 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 198628008492 homodimer interface [polypeptide binding]; other site 198628008493 motif 1; other site 198628008494 motif 2; other site 198628008495 active site 198628008496 motif 3; other site 198628008497 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 198628008498 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 198628008499 trimer interface [polypeptide binding]; other site 198628008500 eyelet of channel; other site 198628008501 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 198628008502 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 198628008503 trimer interface [polypeptide binding]; other site 198628008504 eyelet of channel; other site 198628008505 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 198628008506 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 198628008507 trimer interface [polypeptide binding]; other site 198628008508 eyelet of channel; other site 198628008509 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 198628008510 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 198628008511 pyridoxal 5'-phosphate binding site [chemical binding]; other site 198628008512 homodimer interface [polypeptide binding]; other site 198628008513 catalytic residue [active] 198628008514 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 198628008515 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 198628008516 Peptidase M15; Region: Peptidase_M15_3; cl01194 198628008517 murein L,D-transpeptidase; Provisional; Region: PRK10594 198628008518 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 198628008519 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 198628008520 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 198628008521 hypothetical protein; Validated; Region: PRK00029 198628008522 Uncharacterized conserved protein [Function unknown]; Region: COG0397 198628008523 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290 198628008524 lipoate-protein ligase A; Provisional; Region: lplA; PRK03822 198628008525 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 198628008526 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 198628008527 NlpC/P60 family; Region: NLPC_P60; pfam00877 198628008528 vitamin B12-transporter ATPase; Provisional; Region: PRK03695 198628008529 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 198628008530 Walker A/P-loop; other site 198628008531 ATP binding site [chemical binding]; other site 198628008532 Q-loop/lid; other site 198628008533 ABC transporter signature motif; other site 198628008534 Walker B; other site 198628008535 D-loop; other site 198628008536 H-loop/switch region; other site 198628008537 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 198628008538 catalytic residues [active] 198628008539 dimer interface [polypeptide binding]; other site 198628008540 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 198628008541 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 198628008542 ABC-ATPase subunit interface; other site 198628008543 dimer interface [polypeptide binding]; other site 198628008544 putative PBP binding regions; other site 198628008545 NAD-dependent deacetylase; Provisional; Region: PRK00481 198628008546 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 198628008547 NAD+ binding site [chemical binding]; other site 198628008548 substrate binding site [chemical binding]; other site 198628008549 Zn binding site [ion binding]; other site 198628008550 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 198628008551 fructokinase; Reviewed; Region: PRK09557 198628008552 nucleotide binding site [chemical binding]; other site 198628008553 outer membrane-specific lipoprotein transporter subunit LolE; Provisional; Region: PRK11146 198628008554 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 198628008555 FtsX-like permease family; Region: FtsX; pfam02687 198628008556 lipoprotein transporter ATP-binding subunit; Provisional; Region: lolD; PRK11629 198628008557 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 198628008558 Walker A/P-loop; other site 198628008559 ATP binding site [chemical binding]; other site 198628008560 Q-loop/lid; other site 198628008561 ABC transporter signature motif; other site 198628008562 Walker B; other site 198628008563 D-loop; other site 198628008564 H-loop/switch region; other site 198628008565 outer membrane-specific lipoprotein transporter subunit LolC; Provisional; Region: PRK10814 198628008566 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 198628008567 FtsX-like permease family; Region: FtsX; pfam02687 198628008568 transcription-repair coupling factor; Provisional; Region: PRK10689 198628008569 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 198628008570 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 198628008571 ATP binding site [chemical binding]; other site 198628008572 putative Mg++ binding site [ion binding]; other site 198628008573 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 198628008574 nucleotide binding region [chemical binding]; other site 198628008575 ATP-binding site [chemical binding]; other site 198628008576 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 198628008577 phage resistance protein; Provisional; Region: PRK10551 198628008578 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 198628008579 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 198628008580 putative chaperone; Provisional; Region: PRK11678 198628008581 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 198628008582 nucleotide binding site [chemical binding]; other site 198628008583 putative NEF/HSP70 interaction site [polypeptide binding]; other site 198628008584 SBD interface [polypeptide binding]; other site 198628008585 N-acetyltransferase; Region: Acetyltransf_2; pfam00797 198628008586 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 198628008587 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 198628008588 Glycosyl hydrolase family 31 (GH31) domain of a bacterial protein family represented by Escherichia coli protein Aec37. The gene encoding Aec37 (aec-37) is located within a genomic island (AGI-3) isolated from the extraintestinal avian pathogenic...; Region: GH31_glycosidase_Aec37; cd06599 198628008589 putative active site [active] 198628008590 putative catalytic site [active] 198628008591 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198628008592 D-galactonate transporter; Region: 2A0114; TIGR00893 198628008593 putative substrate translocation pore; other site 198628008594 Transcriptional regulators [Transcription]; Region: PurR; COG1609 198628008595 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 198628008596 DNA binding site [nucleotide binding] 198628008597 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 198628008598 ligand binding site [chemical binding]; other site 198628008599 dimerization interface [polypeptide binding]; other site 198628008600 hypothetical protein; Provisional; Region: PRK11280 198628008601 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 198628008602 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 198628008603 hypothetical protein; Provisional; Region: PRK04940 198628008604 beta-hexosaminidase; Provisional; Region: PRK05337 198628008605 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 198628008606 thiamine kinase; Region: ycfN_thiK; TIGR02721 198628008607 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 198628008608 active site 198628008609 substrate binding site [chemical binding]; other site 198628008610 ATP binding site [chemical binding]; other site 198628008611 Protein of unknown function (DUF3897); Region: DUF3897; cl17494 198628008612 Predicted periplasmic lipoprotein [General function prediction only]; Region: COG5633 198628008613 Putative periplasmic lipoprotein; Region: DUF1425; cd09030 198628008614 putative dimer interface [polypeptide binding]; other site 198628008615 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 198628008616 nucleotide binding site/active site [active] 198628008617 HIT family signature motif; other site 198628008618 catalytic residue [active] 198628008619 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 198628008620 PTS system glucose-specific transporter subunits IIBC; Provisional; Region: PRK11089 198628008621 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 198628008622 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 198628008623 active site turn [active] 198628008624 phosphorylation site [posttranslational modification] 198628008625 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 198628008626 active site 198628008627 DNA polymerase III subunit delta'; Validated; Region: PRK07993 198628008628 DNA polymerase III subunit delta'; Validated; Region: PRK08485 198628008629 DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115 198628008630 thymidylate kinase; Validated; Region: tmk; PRK00698 198628008631 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 198628008632 TMP-binding site; other site 198628008633 ATP-binding site [chemical binding]; other site 198628008634 Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559 198628008635 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 198628008636 dimerization interface [polypeptide binding]; other site 198628008637 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 198628008638 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 198628008639 pyridoxal 5'-phosphate binding site [chemical binding]; other site 198628008640 catalytic residue [active] 198628008641 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 198628008642 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 198628008643 dimer interface [polypeptide binding]; other site 198628008644 active site 198628008645 acyl carrier protein; Provisional; Region: acpP; PRK00982 198628008646 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 198628008647 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 198628008648 NAD(P) binding site [chemical binding]; other site 198628008649 homotetramer interface [polypeptide binding]; other site 198628008650 homodimer interface [polypeptide binding]; other site 198628008651 active site 198628008652 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 198628008653 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 198628008654 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 198628008655 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 198628008656 dimer interface [polypeptide binding]; other site 198628008657 active site 198628008658 CoA binding pocket [chemical binding]; other site 198628008659 putative phosphate acyltransferase; Provisional; Region: PRK05331 198628008660 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 198628008661 hypothetical protein; Provisional; Region: PRK11193 198628008662 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 198628008663 active site 198628008664 dimer interface [polypeptide binding]; other site 198628008665 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 198628008666 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 198628008667 RNA binding surface [nucleotide binding]; other site 198628008668 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 198628008669 active site 198628008670 ribonuclease E; Reviewed; Region: rne; PRK10811 198628008671 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 198628008672 homodimer interface [polypeptide binding]; other site 198628008673 oligonucleotide binding site [chemical binding]; other site 198628008674 Polyribonucleotide phosphorylase C terminal; Region: PNPase_C; pfam12111 198628008675 Uncharacterized conserved protein [Function unknown]; Region: COG1359 198628008676 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 198628008677 active site 198628008678 substrate binding pocket [chemical binding]; other site 198628008679 dimer interface [polypeptide binding]; other site 198628008680 DNA damage-inducible protein I; Provisional; Region: PRK10597 198628008681 biofilm formation regulatory protein BssS; Reviewed; Region: bssS; PRK12301 198628008682 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 198628008683 hypothetical protein; Provisional; Region: PRK03757 198628008684 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 198628008685 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 198628008686 active site residue [active] 198628008687 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 198628008688 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 198628008689 active site 198628008690 FMN binding site [chemical binding]; other site 198628008691 substrate binding site [chemical binding]; other site 198628008692 homotetramer interface [polypeptide binding]; other site 198628008693 catalytic residue [active] 198628008694 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 198628008695 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 198628008696 putative acyl-acceptor binding pocket; other site 198628008697 drug efflux system protein MdtG; Provisional; Region: PRK09874 198628008698 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198628008699 putative substrate translocation pore; other site 198628008700 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 198628008701 Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191 198628008702 Ligand binding site; other site 198628008703 DXD motif; other site 198628008704 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 198628008705 Periplasmic glucan biosynthesis protein, MdoG; Region: MdoG; cl15433 198628008706 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 198628008707 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 198628008708 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 198628008709 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 198628008710 HAMP domain; Region: HAMP; pfam00672 198628008711 dimerization interface [polypeptide binding]; other site 198628008712 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 198628008713 dimer interface [polypeptide binding]; other site 198628008714 putative CheW interface [polypeptide binding]; other site 198628008715 AzlC protein; Region: AzlC; cl00570 198628008716 Protein of unknown function (DUF2566); Region: DUF2566; pfam10753 198628008717 Ter macrodomain organizer matS-binding protein; Provisional; Region: PRK05097 198628008718 Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067 198628008719 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 198628008720 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 198628008721 active site 1 [active] 198628008722 dimer interface [polypeptide binding]; other site 198628008723 active site 2 [active] 198628008724 choline dehydrogenase; Validated; Region: PRK02106 198628008725 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 198628008726 betaine aldehyde dehydrogenase; Provisional; Region: PRK13252 198628008727 NAD+-dependent 4-trimethylaminobutyraldehyde dehydrogenase, ALDH family 9A1; Region: ALDH_F9_TMBADH; cd07090 198628008728 tetrameric interface [polypeptide binding]; other site 198628008729 NAD binding site [chemical binding]; other site 198628008730 catalytic residues [active] 198628008731 transcriptional regulator BetI; Validated; Region: PRK00767 198628008732 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 198628008733 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 198628008734 hypothetical protein; Provisional; Region: PRK09273 198628008735 Ribose 5-phosphate isomerase RpiB [Carbohydrate transport and metabolism]; Region: RpiB; COG0698 198628008736 Ribose-5-phosphate isomerase; Region: DUF3666; pfam12408 198628008737 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 198628008738 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 198628008739 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 198628008740 dimer interface [polypeptide binding]; other site 198628008741 putative CheW interface [polypeptide binding]; other site 198628008742 hypothetical protein; Provisional; Region: PRK10536 198628008743 flagella biosynthesis protein FliZ; Provisional; Region: PRK11582 198628008744 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 198628008745 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 198628008746 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 198628008747 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 198628008748 DNA binding residues [nucleotide binding] 198628008749 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 198628008750 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 198628008751 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 198628008752 ATP-grasp domain; Region: ATP-grasp_4; cl17255 198628008753 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 198628008754 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 198628008755 inhibitor-cofactor binding pocket; inhibition site 198628008756 pyridoxal 5'-phosphate binding site [chemical binding]; other site 198628008757 catalytic residue [active] 198628008759 Transposase IS200 like; Region: Y1_Tnp; pfam01797 198628008760 flagellin; Provisional; Region: PRK12802 198628008761 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 198628008762 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 198628008763 flagellar capping protein; Reviewed; Region: fliD; PRK08032 198628008764 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 198628008765 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 198628008766 flagellar protein FliS; Validated; Region: fliS; PRK05685 198628008767 Flagellar protein FliT; Region: FliT; cl05125 198628008768 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00253 198628008769 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 198628008770 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 198628008771 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 198628008772 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 198628008773 FliG C-terminal domain; Region: FliG_C; pfam01706 198628008774 flagellar assembly protein H; Validated; Region: fliH; PRK05687 198628008775 Flagellar assembly protein FliH; Region: FliH; pfam02108 198628008776 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07960 198628008777 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 198628008778 Walker A motif/ATP binding site; other site 198628008779 Walker B motif; other site 198628008780 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689 198628008781 Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882 198628008782 Flagellar hook-length control protein FliK; Region: Flg_hook; cl17777 198628008783 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07021 198628008784 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 198628008785 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 198628008786 flagellar motor switch protein FliN; Validated; Region: fliN; PRK07963 198628008787 flagellar motor switch protein; Validated; Region: fliN; PRK05698 198628008788 Flagellar biosynthesis protein, FliO; Region: FliO; pfam04347 198628008789 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 198628008790 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 198628008791 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 198628008792 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08027 198628008793 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 198628008794 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK06945 198628008795 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 198628008796 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 198628008797 flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684 198628008798 Rod binding protein [Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3951 198628008799 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 198628008800 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 198628008801 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 198628008802 Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063 198628008803 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 198628008804 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 198628008805 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 198628008806 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 198628008807 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640 198628008808 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 198628008809 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 198628008810 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 198628008811 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 198628008812 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 198628008813 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 198628008814 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655 198628008815 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 198628008816 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 198628008817 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 198628008818 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 198628008819 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 198628008820 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 198628008821 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 198628008822 flagellar basal body P-ring biosynthesis protein FlgA; Reviewed; Region: flgA; PRK07018 198628008823 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 198628008824 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 198628008825 anti-sigma28 factor FlgM; Provisional; Region: PRK10810 198628008826 FlgN protein; Region: FlgN; cl09176 198628008827 Flagellar protein FlhE; Region: FlhE; pfam06366 198628008828 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 198628008829 FHIPEP family; Region: FHIPEP; pfam00771 198628008830 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 198628008831 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 198628008832 chemotaxis regulator CheZ; Provisional; Region: PRK11166 198628008833 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 198628008834 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 198628008835 active site 198628008836 phosphorylation site [posttranslational modification] 198628008837 intermolecular recognition site; other site 198628008838 dimerization interface [polypeptide binding]; other site 198628008839 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 198628008840 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 198628008841 active site 198628008842 phosphorylation site [posttranslational modification] 198628008843 intermolecular recognition site; other site 198628008844 dimerization interface [polypeptide binding]; other site 198628008845 CheB methylesterase; Region: CheB_methylest; pfam01339 198628008846 chemotaxis methyltransferase CheR; Provisional; Region: PRK10611 198628008847 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 198628008848 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 198628008849 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 198628008850 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 198628008851 dimer interface [polypeptide binding]; other site 198628008852 ligand binding site [chemical binding]; other site 198628008853 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 198628008854 dimerization interface [polypeptide binding]; other site 198628008855 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 198628008856 dimer interface [polypeptide binding]; other site 198628008857 putative CheW interface [polypeptide binding]; other site 198628008858 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 198628008859 putative CheA interaction surface; other site 198628008860 chemotaxis protein CheA; Provisional; Region: PRK10547 198628008861 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 198628008862 putative binding surface; other site 198628008863 active site 198628008864 CheY binding; Region: CheY-binding; pfam09078 198628008865 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 198628008866 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 198628008867 ATP binding site [chemical binding]; other site 198628008868 Mg2+ binding site [ion binding]; other site 198628008869 G-X-G motif; other site 198628008870 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 198628008871 flagellar motor protein MotB; Reviewed; Region: motB; PRK12799 198628008872 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 198628008873 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 198628008874 ligand binding site [chemical binding]; other site 198628008875 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 198628008876 flagellar motor protein MotA; Validated; Region: PRK09110 198628008877 transcriptional activator FlhC; Provisional; Region: PRK12722 198628008878 transcriptional activator FlhD; Provisional; Region: PRK02909 198628008879 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 198628008880 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 198628008881 dimer interface [polypeptide binding]; other site 198628008882 active site 198628008883 metal binding site [ion binding]; metal-binding site 198628008884 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 198628008885 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 198628008886 dimer interface [polypeptide binding]; other site 198628008887 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 198628008888 dimerization interface [polypeptide binding]; other site 198628008889 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 198628008890 dimer interface [polypeptide binding]; other site 198628008891 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 198628008892 putative CheW interface [polypeptide binding]; other site 198628008893 hypothetical protein; Provisional; Region: PRK10708 198628008894 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 198628008895 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 198628008896 MATE family multidrug exporter; Provisional; Region: PRK10189 198628008897 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 198628008898 Cytochrome b562; Region: Cytochrom_B562; cl01546 198628008899 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 198628008900 Cellulose-binding domain, chitinase and related proteins; Region: CBD_like; cd12204 198628008901 aromatic chitin/cellulose binding site residues [chemical binding]; other site 198628008902 ligand binding site [chemical binding]; other site 198628008903 Right handed beta helix region; Region: Beta_helix; pfam13229 198628008904 Phage holin family 2; Region: Phage_holin_2; pfam04550 198628008905 The lysozyme from bacteriophage lambda hydrolyses the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc), as do other lysozymes. But unlike other lysozymes, bacteriophage lambda does not produce a reducing...; Region: bacteriophage_lambda_lysozyme; cd00736 198628008906 N-acetyl-D-glucosamine binding site [chemical binding]; other site 198628008907 catalytic residue [active] 198628008908 phage lysis regulatory protein, LysB family; Region: phage_LysB; TIGR03495 198628008909 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_12; cd13142 198628008910 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 198628008911 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454 198628008912 putative active site [active] 198628008913 putative catalytic site [active] 198628008914 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 198628008915 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 198628008916 Cytochrome P450; Region: p450; cl12078 198628008917 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 198628008918 Condensation domain; Region: Condensation; pfam00668 198628008919 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 198628008920 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 198628008921 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 198628008922 Protein of unknown function (DUF3375); Region: DUF3375; pfam11855 198628008923 Domain of unknown function (DUF4194); Region: DUF4194; pfam13835 198628008924 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4913 198628008925 P-loop containing region of AAA domain; Region: AAA_29; pfam13555 198628008926 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 198628008927 Uncharacterized protein conserved in bacteria N-term (DUF3322); Region: DUF3322; pfam11795 198628008928 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4924 198628008929 Uncharacterized protein conserved in bacteria C-term(DUF2220); Region: DUF2220; pfam09983 198628008930 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 198628008931 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 198628008932 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 198628008933 GIY-YIG motif/motif A; other site 198628008934 active site 198628008935 catalytic site [active] 198628008936 putative DNA binding site [nucleotide binding]; other site 198628008937 metal binding site [ion binding]; metal-binding site 198628008938 UvrB/uvrC motif; Region: UVR; pfam02151 198628008939 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 198628008940 response regulator; Provisional; Region: PRK09483 198628008941 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 198628008942 active site 198628008943 phosphorylation site [posttranslational modification] 198628008944 intermolecular recognition site; other site 198628008945 dimerization interface [polypeptide binding]; other site 198628008946 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 198628008947 DNA binding residues [nucleotide binding] 198628008948 dimerization interface [polypeptide binding]; other site 198628008949 hypothetical protein; Provisional; Region: PRK10613 198628008950 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 198628008951 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 198628008952 integrase; Provisional; Region: PRK09692 198628008953 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 198628008954 active site 198628008955 Int/Topo IB signature motif; other site 198628008956 Uncharacterized conserved protein [Function unknown]; Region: COG5489 198628008957 PAAR motif; Region: PAAR_motif; pfam05488 198628008958 RHS Repeat; Region: RHS_repeat; cl11982 198628008959 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 198628008960 RHS Repeat; Region: RHS_repeat; pfam05593 198628008961 RHS Repeat; Region: RHS_repeat; pfam05593 198628008962 RHS Repeat; Region: RHS_repeat; cl11982 198628008963 RHS Repeat; Region: RHS_repeat; cl11982 198628008964 RHS Repeat; Region: RHS_repeat; cl11982 198628008965 RHS Repeat; Region: RHS_repeat; pfam05593 198628008966 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 198628008967 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 198628008968 active site 198628008969 Domain of unknown function (DUF1795); Region: DUF1795; pfam08786 198628008970 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 198628008971 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 198628008972 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 198628008973 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 198628008974 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 198628008975 non-specific DNA binding site [nucleotide binding]; other site 198628008976 salt bridge; other site 198628008977 sequence-specific DNA binding site [nucleotide binding]; other site 198628008978 Winged helix-turn-helix DNA-binding; Region: HTH_35; pfam13693 198628008979 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 198628008980 non-specific DNA binding site [nucleotide binding]; other site 198628008981 salt bridge; other site 198628008982 sequence-specific DNA binding site [nucleotide binding]; other site 198628008983 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 198628008984 non-specific DNA binding site [nucleotide binding]; other site 198628008985 salt bridge; other site 198628008986 sequence-specific DNA binding site [nucleotide binding]; other site 198628008987 Winged helix-turn-helix DNA-binding; Region: HTH_35; pfam13693 198628008988 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 198628008989 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 198628008990 non-specific DNA binding site [nucleotide binding]; other site 198628008991 salt bridge; other site 198628008992 sequence-specific DNA binding site [nucleotide binding]; other site 198628008993 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 198628008994 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 198628008995 non-specific DNA binding site [nucleotide binding]; other site 198628008996 salt bridge; other site 198628008997 sequence-specific DNA binding site [nucleotide binding]; other site 198628008998 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 198628008999 Protein of unknown function (DUF2857); Region: DUF2857; pfam11198 198628009000 Domain of unknown function (DUF4209); Region: DUF4209; pfam13910 198628009001 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 198628009002 N-acetyl-D-glucosamine binding site [chemical binding]; other site 198628009003 catalytic residue [active] 198628009004 TrbC/VIRB2 family; Region: TrbC; pfam04956 198628009005 Type IV secretory pathway, VirB3-like protein; Region: VirB3; cl01501 198628009006 type IV secretion/conjugal transfer ATPase, VirB4 family; Region: VirB4_CagE; TIGR00929 198628009007 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 198628009008 P-type DNA transfer protein VirB5; Region: VirB5; TIGR02791 198628009009 Type IV secretion system proteins; Region: T4SS; pfam07996 198628009010 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; pfam04610 198628009011 VirB8 protein; Region: VirB8; pfam04335 198628009012 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 198628009013 VirB7 interaction site; other site 198628009014 Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743 198628009015 P-type DNA transfer ATPase VirB11; Region: VirB11; TIGR02788 198628009016 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 198628009017 Walker A motif; other site 198628009018 hexamer interface [polypeptide binding]; other site 198628009019 ATP binding site [chemical binding]; other site 198628009020 Walker B motif; other site 198628009021 TrbM; Region: TrbM; pfam07424 198628009022 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375 198628009023 Transposase; Region: DEDD_Tnp_IS110; pfam01548 198628009024 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 198628009025 CcdB protein; Region: CcdB; pfam01845 198628009026 Post-segregation antitoxin CcdA; Region: CcdA; pfam07362 198628009027 Integrase core domain; Region: rve_3; cl15866 198628009028 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 198628009029 putative catalytic site [active] 198628009030 putative metal binding site [ion binding]; other site 198628009031 putative phosphate binding site [ion binding]; other site 198628009032 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 198628009033 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 198628009034 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 198628009035 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 198628009036 CcdB protein; Region: CcdB; pfam01845 198628009037 Post-segregation antitoxin CcdA; Region: CcdA; pfam07362 198628009038 Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227 198628009039 Domain of unknown function (DUF1738); Region: DUF1738; pfam08401 198628009040 Domain of unknown function (DUF4016); Region: DUF4016; pfam13208 198628009041 sporadically distributed protein, TIGR04141 family; Region: TIGR04141 198628009042 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 198628009043 His-Xaa-Ser system radical SAM maturase HxsC; Region: rSAM_pair_HxsC; TIGR03977 198628009044 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 198628009045 FeS/SAM binding site; other site 198628009046 His-Xaa-Ser system radical SAM maturase HxsB; Region: rSAM_paired_1; TIGR03978 198628009047 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 198628009048 FeS/SAM binding site; other site 198628009049 His-Xaa-Ser system protein HsxD; Region: chp_LLNDYxLRE; TIGR03976 198628009050 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 198628009051 DNA-binding interface [nucleotide binding]; DNA binding site 198628009052 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 198628009053 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 198628009054 homodimer interface [polypeptide binding]; other site 198628009055 active site 198628009056 TDP-binding site; other site 198628009057 acceptor substrate-binding pocket; other site 198628009058 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 198628009059 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 198628009060 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 198628009061 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 198628009062 HAMP domain; Region: HAMP; pfam00672 198628009063 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 198628009064 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 198628009065 dimer interface [polypeptide binding]; other site 198628009066 putative CheW interface [polypeptide binding]; other site 198628009067 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 198628009068 putative dimer interface [polypeptide binding]; other site 198628009069 catalytic triad [active] 198628009070 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 198628009071 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 198628009072 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 198628009073 dimerization interface [polypeptide binding]; other site 198628009074 putative aminotransferase; Provisional; Region: PRK12414 198628009075 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 198628009076 pyridoxal 5'-phosphate binding site [chemical binding]; other site 198628009077 homodimer interface [polypeptide binding]; other site 198628009078 catalytic residue [active] 198628009079 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 198628009080 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 198628009081 substrate binding pocket [chemical binding]; other site 198628009082 membrane-bound complex binding site; other site 198628009083 hinge residues; other site 198628009084 Predicted flavoprotein [General function prediction only]; Region: COG0431 198628009085 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 198628009086 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 198628009087 active site 198628009088 SAM binding site [chemical binding]; other site 198628009089 homodimer interface [polypeptide binding]; other site 198628009090 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 198628009091 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 198628009092 [4Fe-4S] binding site [ion binding]; other site 198628009093 molybdopterin cofactor binding site; other site 198628009094 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 198628009095 molybdopterin cofactor binding site; other site 198628009096 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 198628009097 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 198628009098 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 198628009099 nitrite reductase subunit NirD; Provisional; Region: PRK14989 198628009100 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 198628009101 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 198628009102 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 198628009103 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 198628009104 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 198628009105 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 198628009106 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 198628009107 Walker A/P-loop; other site 198628009108 ATP binding site [chemical binding]; other site 198628009109 Q-loop/lid; other site 198628009110 ABC transporter signature motif; other site 198628009111 Walker B; other site 198628009112 D-loop; other site 198628009113 H-loop/switch region; other site 198628009114 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 198628009115 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198628009116 dimer interface [polypeptide binding]; other site 198628009117 conserved gate region; other site 198628009118 putative PBP binding loops; other site 198628009119 ABC-ATPase subunit interface; other site 198628009120 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 198628009121 NMT1-like family; Region: NMT1_2; pfam13379 198628009122 Nitrate and nitrite sensing; Region: NIT; pfam08376 198628009123 ANTAR domain; Region: ANTAR; pfam03861 198628009124 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 198628009125 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 198628009126 Protein export membrane protein; Region: SecD_SecF; cl14618 198628009127 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 198628009128 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 198628009129 HlyD family secretion protein; Region: HlyD_3; pfam13437 198628009130 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 198628009131 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 198628009132 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 198628009133 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198628009134 putative substrate translocation pore; other site 198628009135 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 198628009136 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 198628009137 formate dehydrogenase accessory protein FdhE; Provisional; Region: PRK03564 198628009138 formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562 198628009139 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 198628009140 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198628009141 putative substrate translocation pore; other site 198628009142 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198628009143 HipA N-terminal domain; Region: Couple_hipA; cl11853 198628009144 HipA-like N-terminal domain; Region: HipA_N; pfam07805 198628009145 HipA-like C-terminal domain; Region: HipA_C; pfam07804 198628009146 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 198628009147 non-specific DNA binding site [nucleotide binding]; other site 198628009148 salt bridge; other site 198628009149 sequence-specific DNA binding site [nucleotide binding]; other site 198628009150 formate dehydrogenase-O subunit gamma; Provisional; Region: PRK10639 198628009151 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 198628009152 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 198628009153 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 198628009154 formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553 198628009155 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 198628009156 [4Fe-4S] binding site [ion binding]; other site 198628009157 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 198628009158 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 198628009159 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 198628009160 molybdopterin cofactor binding site; other site 198628009161 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 198628009162 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 198628009163 DNA-binding site [nucleotide binding]; DNA binding site 198628009164 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 198628009165 pyridoxal 5'-phosphate binding site [chemical binding]; other site 198628009166 homodimer interface [polypeptide binding]; other site 198628009167 catalytic residue [active] 198628009168 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 198628009169 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 198628009170 catalytic triad [active] 198628009171 sigma70 family sigma factor YlaC; Region: YlaC; pfam10777 198628009172 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 198628009173 Acylphosphatase; Region: Acylphosphatase; pfam00708 198628009174 HypF finger; Region: zf-HYPF; pfam07503 198628009175 HypF finger; Region: zf-HYPF; pfam07503 198628009176 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 198628009177 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 198628009178 Transposase; Region: DEDD_Tnp_IS110; pfam01548 198628009179 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 198628009180 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 198628009181 dimerization interface [polypeptide binding]; other site 198628009182 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 198628009183 ATP binding site [chemical binding]; other site 198628009184 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 198628009185 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 198628009186 hydrogenase 2 accessory protein HypG; Provisional; Region: PRK10413 198628009187 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 198628009188 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 198628009189 Hydrogenase expression/synthesis hypA family; Region: HypA; cl17671 198628009190 Protein of unknown function (DUF3457); Region: DUF3457; cl08122 198628009191 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 198628009192 nickel binding site [ion binding]; other site 198628009193 putative substrate-binding site; other site 198628009194 hydrogenase 2 large subunit; Provisional; Region: PRK10467 198628009195 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 198628009196 putative hydrogenase 2 b cytochrome subunit; Provisional; Region: PRK10881 198628009197 hydrogenase 2 protein HybA; Provisional; Region: PRK10882 198628009198 4Fe-4S binding domain; Region: Fer4; cl02805 198628009199 hydrogenase 2 small subunit; Provisional; Region: PRK10468 198628009200 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 198628009201 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 198628009202 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 198628009203 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 198628009204 Walker A/P-loop; other site 198628009205 ATP binding site [chemical binding]; other site 198628009206 Q-loop/lid; other site 198628009207 ABC transporter signature motif; other site 198628009208 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 198628009209 Walker B; other site 198628009210 D-loop; other site 198628009211 H-loop/switch region; other site 198628009212 ABC transporter; Region: ABC_tran_2; pfam12848 198628009213 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 198628009214 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 198628009215 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 198628009216 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 198628009217 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 198628009218 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 198628009219 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 198628009220 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 198628009221 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 198628009222 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 198628009223 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 198628009224 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 198628009225 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 198628009226 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 198628009227 NADH:ubiquinone oxidoreductase subunit 6 (chain J) [Energy production and conversion]; Region: NuoJ; COG0839 198628009228 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 198628009229 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 198628009230 4Fe-4S binding domain; Region: Fer4; cl02805 198628009231 4Fe-4S binding domain; Region: Fer4; pfam00037 198628009232 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 198628009233 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 198628009234 NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) [Energy production and conversion]; Region: NuoG; COG1034 198628009235 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 198628009236 catalytic loop [active] 198628009237 iron binding site [ion binding]; other site 198628009238 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 198628009239 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 198628009240 [4Fe-4S] binding site [ion binding]; other site 198628009241 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 198628009242 NADH dehydrogenase I subunit F; Provisional; Region: PRK11278 198628009243 SLBB domain; Region: SLBB; pfam10531 198628009244 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 198628009245 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 198628009246 NADH dehydrogenase subunit E; Validated; Region: PRK07539 198628009247 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 198628009248 putative dimer interface [polypeptide binding]; other site 198628009249 [2Fe-2S] cluster binding site [ion binding]; other site 198628009250 bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742 198628009251 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 198628009252 NADH dehydrogenase subunit D; Validated; Region: PRK06075 198628009253 NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377 198628009254 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 198628009255 DNA-binding transcriptional repressor LrhA; Provisional; Region: PRK15092 198628009256 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 198628009257 The C-terminal substrate domain of LysR-like regulator LrhA (LysR homologue A) and that of closely related homologs, contains the type 2 periplasmic binding fold; Region: PBP2_LrhA_like; cd08439 198628009258 putative dimerization interface [polypeptide binding]; other site 198628009259 aminotransferase AlaT; Validated; Region: PRK09265 198628009260 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 198628009261 pyridoxal 5'-phosphate binding site [chemical binding]; other site 198628009262 homodimer interface [polypeptide binding]; other site 198628009263 catalytic residue [active] 198628009264 5'-nucleotidase; Provisional; Region: PRK03826 198628009265 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 198628009266 transmembrane helices; other site 198628009267 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 198628009268 TrkA-C domain; Region: TrkA_C; pfam02080 198628009269 TrkA-C domain; Region: TrkA_C; pfam02080 198628009270 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 198628009271 putative phosphatase; Provisional; Region: PRK11587 198628009272 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 198628009273 motif II; other site 198628009274 hypothetical protein; Validated; Region: PRK05445 198628009275 hypothetical protein; Provisional; Region: PRK01816 198628009276 propionate/acetate kinase; Provisional; Region: PRK12379 198628009277 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 198628009278 phosphate acetyltransferase; Reviewed; Region: PRK05632 198628009279 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 198628009280 DRTGG domain; Region: DRTGG; pfam07085 198628009281 phosphate acetyltransferase; Region: pta; TIGR00651 198628009282 NUDIX hydrolase YfcD; Provisional; Region: PRK15393 198628009283 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 198628009284 nudix motif; other site 198628009285 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 198628009286 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 198628009287 active site 198628009288 metal binding site [ion binding]; metal-binding site 198628009289 homotetramer interface [polypeptide binding]; other site 198628009290 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 198628009291 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 198628009292 C-terminal domain interface [polypeptide binding]; other site 198628009293 GSH binding site (G-site) [chemical binding]; other site 198628009294 dimer interface [polypeptide binding]; other site 198628009295 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 198628009296 N-terminal domain interface [polypeptide binding]; other site 198628009297 putative dimer interface [polypeptide binding]; other site 198628009298 active site 198628009299 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 198628009300 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 198628009301 putative NAD(P) binding site [chemical binding]; other site 198628009302 putative active site [active] 198628009303 histidine/lysine/arginine/ornithine transporter subunit; Provisional; Region: PRK10619 198628009304 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 198628009305 Walker A/P-loop; other site 198628009306 ATP binding site [chemical binding]; other site 198628009307 Q-loop/lid; other site 198628009308 ABC transporter signature motif; other site 198628009309 Walker B; other site 198628009310 D-loop; other site 198628009311 H-loop/switch region; other site 198628009312 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 198628009313 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198628009314 dimer interface [polypeptide binding]; other site 198628009315 conserved gate region; other site 198628009316 putative PBP binding loops; other site 198628009317 ABC-ATPase subunit interface; other site 198628009318 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 198628009319 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198628009320 dimer interface [polypeptide binding]; other site 198628009321 conserved gate region; other site 198628009322 putative PBP binding loops; other site 198628009323 ABC-ATPase subunit interface; other site 198628009324 histidine ABC transporter substrate-binding protein HisJ; Provisional; Region: PRK15437 198628009325 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 198628009326 substrate binding pocket [chemical binding]; other site 198628009327 membrane-bound complex binding site; other site 198628009328 hinge residues; other site 198628009329 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 198628009330 Flavoprotein; Region: Flavoprotein; pfam02441 198628009331 amidophosphoribosyltransferase; Provisional; Region: PRK09246 198628009332 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 198628009333 active site 198628009334 tetramer interface [polypeptide binding]; other site 198628009335 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 198628009336 active site 198628009337 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 198628009338 colicin V production protein; Provisional; Region: PRK10845 198628009339 Sporulation related domain; Region: SPOR; pfam05036 198628009340 bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846 198628009341 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 198628009342 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 198628009343 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 198628009344 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 198628009345 hypothetical protein; Provisional; Region: PRK10847 198628009346 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 198628009347 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 198628009348 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 198628009349 dimerization interface 3.5A [polypeptide binding]; other site 198628009350 active site 198628009351 putative semialdehyde dehydrogenase; Provisional; Region: PRK08040 198628009352 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 198628009353 erythronate-4-phosphate dehydrogenase PdxB; Provisional; Region: PRK15438 198628009354 D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158 198628009355 ligand binding site [chemical binding]; other site 198628009356 NAD binding site [chemical binding]; other site 198628009357 catalytic site [active] 198628009358 homodimer interface [polypeptide binding]; other site 198628009359 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 198628009360 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 198628009361 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 198628009362 dimer interface [polypeptide binding]; other site 198628009363 phosphorylation site [posttranslational modification] 198628009364 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 198628009365 ATP binding site [chemical binding]; other site 198628009366 G-X-G motif; other site 198628009367 transcriptional regulatory protein TctD; Provisional; Region: PRK15479 198628009368 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 198628009369 active site 198628009370 phosphorylation site [posttranslational modification] 198628009371 intermolecular recognition site; other site 198628009372 dimerization interface [polypeptide binding]; other site 198628009373 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 198628009374 DNA binding site [nucleotide binding] 198628009375 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 198628009376 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 198628009377 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 198628009378 flagella biosynthesis regulator; Provisional; Region: flk; PRK10715 198628009379 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 198628009380 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 198628009381 dimer interface [polypeptide binding]; other site 198628009382 active site 198628009383 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 198628009384 Uncharacterized conserved protein [Function unknown]; Region: COG4121 198628009385 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 198628009386 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 198628009387 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 198628009388 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 198628009389 AzlC protein; Region: AzlC; cl00570 198628009390 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 198628009391 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 198628009392 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 198628009393 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 198628009394 putative C-terminal domain interface [polypeptide binding]; other site 198628009395 putative GSH binding site (G-site) [chemical binding]; other site 198628009396 putative dimer interface [polypeptide binding]; other site 198628009397 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 198628009398 N-terminal domain interface [polypeptide binding]; other site 198628009399 dimer interface [polypeptide binding]; other site 198628009400 substrate binding pocket (H-site) [chemical binding]; other site 198628009401 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 198628009402 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 198628009403 potential catalytic triad [active] 198628009404 conserved cys residue [active] 198628009405 Coniferyl aldehyde dehydrogenase-like; Region: ALDH_CALDH_CalB; cd07133 198628009406 NAD(P) binding site [chemical binding]; other site 198628009407 catalytic residues [active] 198628009408 Transcriptional regulator [Transcription]; Region: LysR; COG0583 198628009409 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 198628009410 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 198628009411 dimerization interface [polypeptide binding]; other site 198628009412 YfcL protein; Region: YfcL; pfam08891 198628009413 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3101 198628009414 hypothetical protein; Provisional; Region: PRK10621 198628009415 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 198628009416 penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429 198628009417 Murein endopeptidase [Cell envelope biogenesis, outer membrane]; Region: MepA; COG3770 198628009418 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 198628009419 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 198628009420 Tetramer interface [polypeptide binding]; other site 198628009421 active site 198628009422 FMN-binding site [chemical binding]; other site 198628009423 HemK family putative methylases; Region: hemK_fam; TIGR00536 198628009424 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 198628009425 S-adenosylmethionine binding site [chemical binding]; other site 198628009426 hypothetical protein; Provisional; Region: PRK04946 198628009427 Smr domain; Region: Smr; pfam01713 198628009428 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 198628009429 catalytic core [active] 198628009430 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 198628009431 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 198628009432 substrate binding site [chemical binding]; other site 198628009433 oxyanion hole (OAH) forming residues; other site 198628009434 trimer interface [polypeptide binding]; other site 198628009435 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 198628009436 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 198628009437 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 198628009438 3-ketoacyl-CoA thiolase; Reviewed; Region: fadI; PRK08963 198628009439 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 198628009440 dimer interface [polypeptide binding]; other site 198628009441 active site 198628009442 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3691 198628009443 long-chain fatty acid outer membrane transporter; Provisional; Region: PRK10716 198628009444 malate:quinone oxidoreductase; Validated; Region: PRK05257 198628009445 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 198628009446 VacJ like lipoprotein; Region: VacJ; cl01073 198628009447 Necrosis inducing protein (NPP1); Region: NPP1; pfam05630 198628009448 Predicted secreted acid phosphatase [General function prediction only]; Region: COG2503 198628009449 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 198628009450 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 198628009451 putative trimer interface [polypeptide binding]; other site 198628009452 putative CoA binding site [chemical binding]; other site 198628009453 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 198628009454 iron-enterobactin transporter periplasmic binding protein; Provisional; Region: PRK10957 198628009455 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 198628009456 intersubunit interface [polypeptide binding]; other site 198628009457 enterobactin exporter EntS; Provisional; Region: PRK10489 198628009458 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198628009459 putative substrate translocation pore; other site 198628009460 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 198628009461 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 198628009462 ABC-ATPase subunit interface; other site 198628009463 dimer interface [polypeptide binding]; other site 198628009464 putative PBP binding regions; other site 198628009465 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 198628009466 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 198628009467 ABC-ATPase subunit interface; other site 198628009468 dimer interface [polypeptide binding]; other site 198628009469 putative PBP binding regions; other site 198628009470 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 198628009471 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 198628009472 Walker A/P-loop; other site 198628009473 ATP binding site [chemical binding]; other site 198628009474 Q-loop/lid; other site 198628009475 ABC transporter signature motif; other site 198628009476 Walker B; other site 198628009477 D-loop; other site 198628009478 H-loop/switch region; other site 198628009479 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 198628009480 Transposase; Region: DEDD_Tnp_IS110; pfam01548 198628009481 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 198628009482 Condensation domain; Region: Condensation; pfam00668 198628009483 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 198628009484 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 198628009485 acyl-activating enzyme (AAE) consensus motif; other site 198628009486 AMP binding site [chemical binding]; other site 198628009487 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 198628009488 Condensation domain; Region: Condensation; pfam00668 198628009489 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 198628009490 Condensation domain; Region: Condensation; pfam00668 198628009491 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 198628009492 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 198628009493 acyl-activating enzyme (AAE) consensus motif; other site 198628009494 AMP binding site [chemical binding]; other site 198628009495 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 198628009496 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 198628009497 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3251 198628009498 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 198628009499 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 198628009500 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 198628009501 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 198628009502 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 198628009503 N-terminal plug; other site 198628009504 ligand-binding site [chemical binding]; other site 198628009505 isochorismate synthase EntC; Provisional; Region: PRK15016 198628009506 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 198628009507 enterobactin synthase subunit E; Provisional; Region: entE; PRK10946 198628009508 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 198628009509 acyl-activating enzyme (AAE) consensus motif; other site 198628009510 active site 198628009511 AMP binding site [chemical binding]; other site 198628009512 substrate binding site [chemical binding]; other site 198628009513 Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013 198628009514 hydrophobic substrate binding pocket; other site 198628009515 Isochorismatase family; Region: Isochorismatase; pfam00857 198628009516 active site 198628009517 conserved cis-peptide bond; other site 198628009518 Phosphopantetheine attachment site; Region: PP-binding; cl09936 198628009519 2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220 198628009520 2,3 dihydro-2,3 dihydrozybenzoate dehydrogenases, classical (c) SDRs; Region: DH-DHB-DH_SDR_c; cd05331 198628009521 putative NAD(P) binding site [chemical binding]; other site 198628009522 active site 198628009523 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 198628009524 CoenzymeA binding site [chemical binding]; other site 198628009525 subunit interaction site [polypeptide binding]; other site 198628009526 PHB binding site; other site 198628009527 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 198628009528 Transposase; Region: DEDD_Tnp_IS110; pfam01548 198628009529 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 198628009530 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 198628009531 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 198628009532 FMN binding site [chemical binding]; other site 198628009533 active site 198628009534 substrate binding site [chemical binding]; other site 198628009535 catalytic residue [active] 198628009536 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 198628009537 Serine hydrolase; Region: Ser_hydrolase; pfam06821 198628009538 YeaK is an uncharacterized Echerichia coli protein with a YbaK-like domain of unknown function. The YbaK-like domain family includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting...; Region: YeaK; cd04336 198628009539 putative deacylase active site [active] 198628009540 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 198628009541 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 198628009542 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 198628009543 Type II secretion system (T2SS), protein M; Region: T2SM; pfam04612 198628009544 type II secretion system protein L; Region: typeII_sec_gspL; TIGR01709 198628009545 Type II secretion system (T2SS), protein L; Region: T2SL; pfam05134 198628009546 GspL periplasmic domain; Region: GspL_C; pfam12693 198628009547 Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934 198628009548 type II secretion system protein J; Region: gspJ; TIGR01711 198628009549 Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612 198628009550 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 198628009551 type II secretion system protein I; Region: gspI; TIGR01707 198628009552 Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501 198628009553 type II secretion system protein H; Region: typeII_sec_gspH; TIGR01708 198628009554 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 198628009555 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 198628009556 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 198628009557 type II secretion system protein F; Region: GspF; TIGR02120 198628009558 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 198628009559 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 198628009560 type II secretion system protein E; Region: type_II_gspE; TIGR02533 198628009561 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 198628009562 Walker A motif; other site 198628009563 ATP binding site [chemical binding]; other site 198628009564 Walker B motif; other site 198628009565 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 198628009566 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 198628009567 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 198628009568 pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519 198628009569 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 198628009570 type II secretion system protein C; Region: typeII_sec_gspC; TIGR01713 198628009571 Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356 198628009572 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 198628009573 coordinates annotated as reported with internal stop codon, but experiments within report suggest that start codon is not precisely known 198628009574 lipoprotein, PulS/OutS family; Region: PulS_OutS; TIGR01004 198628009575 aminotransferase; Validated; Region: PRK08175 198628009576 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 198628009577 pyridoxal 5'-phosphate binding site [chemical binding]; other site 198628009578 homodimer interface [polypeptide binding]; other site 198628009579 catalytic residue [active] 198628009580 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 198628009581 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 198628009582 homodimer interface [polypeptide binding]; other site 198628009583 substrate-cofactor binding pocket; other site 198628009584 pyridoxal 5'-phosphate binding site [chemical binding]; other site 198628009585 catalytic residue [active] 198628009586 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264 198628009587 Protein of unknown function (DUF3772); Region: DUF3772; pfam12607 198628009588 Mechanosensitive ion channel; Region: MS_channel; pfam00924 198628009589 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 198628009590 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 198628009591 Helix-turn-helix domain; Region: HTH_28; pfam13518 198628009592 Helix-turn-helix domain; Region: HTH_28; pfam13518 198628009593 putative transposase OrfB; Reviewed; Region: PHA02517 198628009594 HTH-like domain; Region: HTH_21; pfam13276 198628009595 Integrase core domain; Region: rve; pfam00665 198628009596 Integrase core domain; Region: rve_2; pfam13333 198628009597 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 198628009598 active site 198628009599 P-loop; other site 198628009600 phosphorylation site [posttranslational modification] 198628009601 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 198628009602 Uncharacterized conserved protein [Function unknown]; Region: COG2850 198628009603 Putative motility protein; Region: YjfB_motility; pfam14070 198628009604 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 198628009605 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 198628009606 Pirin-related protein [General function prediction only]; Region: COG1741 198628009607 Pirin; Region: Pirin; pfam02678 198628009608 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 198628009609 Transcriptional regulator [Transcription]; Region: LysR; COG0583 198628009610 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 198628009611 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 198628009612 dimerization interface [polypeptide binding]; other site 198628009613 lac repressor; Reviewed; Region: lacI; PRK09526 198628009614 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 198628009615 DNA binding site [nucleotide binding] 198628009616 domain linker motif; other site 198628009617 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 198628009618 ligand binding site [chemical binding]; other site 198628009619 dimerization interface (open form) [polypeptide binding]; other site 198628009620 dimerization interface (closed form) [polypeptide binding]; other site 198628009621 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 198628009622 trimer interface; other site 198628009623 sugar binding site [chemical binding]; other site 198628009624 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 198628009625 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 198628009626 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 198628009627 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 198628009628 Glycosyl hydrolase family 53; Region: Glyco_hydro_53; cl06672 198628009629 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 198628009630 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198628009631 dimer interface [polypeptide binding]; other site 198628009632 conserved gate region; other site 198628009633 putative PBP binding loops; other site 198628009634 ABC-ATPase subunit interface; other site 198628009635 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198628009636 dimer interface [polypeptide binding]; other site 198628009637 conserved gate region; other site 198628009638 ABC-ATPase subunit interface; other site 198628009639 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 198628009640 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 198628009641 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 198628009642 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 198628009643 Walker A/P-loop; other site 198628009644 ATP binding site [chemical binding]; other site 198628009645 Q-loop/lid; other site 198628009646 ABC transporter signature motif; other site 198628009647 Walker B; other site 198628009648 D-loop; other site 198628009649 H-loop/switch region; other site 198628009650 TOBE domain; Region: TOBE; pfam03459 198628009651 TOBE domain; Region: TOBE_2; pfam08402 198628009652 M20 Peptidase Aminoacylase 1 amhX_like subfamily; Region: M20_Acy1_amhX_like; cd08018 198628009653 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 198628009654 metal binding site [ion binding]; metal-binding site 198628009655 putative dimer interface [polypeptide binding]; other site 198628009656 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 198628009657 Pectate lyase; Region: Pectate_lyase; pfam03211 198628009658 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 198628009659 metal binding site [ion binding]; metal-binding site 198628009660 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 198628009661 The starvation sensing protein RpsA from E.coli and its homologs are lactonizing enzymes whose putative targets are homoserine lactone (HSL)-derivative. They are part of the mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of...; Region: rpsA; cd03322 198628009662 putative active site pocket [active] 198628009663 putative metal binding site [ion binding]; other site 198628009664 putative oxidoreductase; Provisional; Region: PRK10083 198628009665 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 198628009666 putative NAD(P) binding site [chemical binding]; other site 198628009667 catalytic Zn binding site [ion binding]; other site 198628009668 structural Zn binding site [ion binding]; other site 198628009669 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198628009670 metabolite-proton symporter; Region: 2A0106; TIGR00883 198628009671 putative substrate translocation pore; other site 198628009672 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 198628009673 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 198628009674 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 198628009675 Transcriptional regulators [Transcription]; Region: GntR; COG1802 198628009676 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 198628009677 DNA-binding site [nucleotide binding]; DNA binding site 198628009678 FCD domain; Region: FCD; pfam07729 198628009679 urocanate hydratase; Provisional; Region: PRK05414 198628009680 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 198628009681 active sites [active] 198628009682 tetramer interface [polypeptide binding]; other site 198628009683 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 198628009684 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 198628009685 Walker A/P-loop; other site 198628009686 ATP binding site [chemical binding]; other site 198628009687 Q-loop/lid; other site 198628009688 ABC transporter signature motif; other site 198628009689 Walker B; other site 198628009690 D-loop; other site 198628009691 H-loop/switch region; other site 198628009692 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 198628009693 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198628009694 dimer interface [polypeptide binding]; other site 198628009695 conserved gate region; other site 198628009696 putative PBP binding loops; other site 198628009697 ABC-ATPase subunit interface; other site 198628009698 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 198628009699 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 198628009700 substrate binding pocket [chemical binding]; other site 198628009701 membrane-bound complex binding site; other site 198628009702 hinge residues; other site 198628009703 Flagellin N-methylase; Region: FliB; pfam03692 198628009704 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 198628009705 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 198628009706 DNA-binding site [nucleotide binding]; DNA binding site 198628009707 UTRA domain; Region: UTRA; pfam07702 198628009708 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 198628009709 active sites [active] 198628009710 tetramer interface [polypeptide binding]; other site 198628009711 ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598 198628009712 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 198628009713 Walker A/P-loop; other site 198628009714 ATP binding site [chemical binding]; other site 198628009715 Q-loop/lid; other site 198628009716 ABC transporter signature motif; other site 198628009717 Walker B; other site 198628009718 D-loop; other site 198628009719 H-loop/switch region; other site 198628009720 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 198628009721 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198628009722 dimer interface [polypeptide binding]; other site 198628009723 conserved gate region; other site 198628009724 putative PBP binding loops; other site 198628009725 ABC-ATPase subunit interface; other site 198628009726 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 198628009727 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198628009728 dimer interface [polypeptide binding]; other site 198628009729 conserved gate region; other site 198628009730 putative PBP binding loops; other site 198628009731 ABC-ATPase subunit interface; other site 198628009732 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 198628009733 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 198628009734 substrate binding pocket [chemical binding]; other site 198628009735 membrane-bound complex binding site; other site 198628009736 hinge residues; other site 198628009737 HutD; Region: HutD; pfam05962 198628009738 N-formimino-L-glutamate deiminase; Validated; Region: PRK09229 198628009739 Metallo-dependent hydrolases, subgroup D is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_E; cd01313 198628009740 active site 198628009741 imidazolonepropionase; Validated; Region: PRK09356 198628009742 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 198628009743 active site 198628009744 N-formylglutamate amidohydrolase; Region: FGase; cl01522 198628009745 Nitrate and nitrite sensing; Region: NIT; pfam08376 198628009746 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 198628009747 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 198628009748 dimer interface [polypeptide binding]; other site 198628009749 putative CheW interface [polypeptide binding]; other site 198628009750 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792 198628009751 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 198628009752 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 198628009753 homodimer interface [polypeptide binding]; other site 198628009754 NADP binding site [chemical binding]; other site 198628009755 substrate binding site [chemical binding]; other site 198628009756 ribosome-associated protein; Provisional; Region: PRK11507 198628009757 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 198628009758 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 198628009759 active site 198628009760 HIGH motif; other site 198628009761 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 198628009762 KMSKS motif; other site 198628009763 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 198628009764 tRNA binding surface [nucleotide binding]; other site 198628009765 anticodon binding site; other site 198628009766 DoxX; Region: DoxX; pfam07681 198628009767 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 198628009768 substrate binding site [chemical binding]; other site 198628009769 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 198628009770 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 198628009771 putative active site [active] 198628009772 putative metal binding site [ion binding]; other site 198628009773 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 198628009774 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 198628009775 ATP-grasp domain; Region: ATP-grasp; pfam02222 198628009776 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 198628009777 serine transporter; Region: stp; TIGR00814 198628009778 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 198628009779 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 198628009780 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 198628009781 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 198628009782 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 198628009783 non-specific DNA binding site [nucleotide binding]; other site 198628009784 salt bridge; other site 198628009785 sequence-specific DNA binding site [nucleotide binding]; other site 198628009786 phosphate transporter ATP-binding protein; Provisional; Region: PRK14236 198628009787 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 198628009788 Walker A/P-loop; other site 198628009789 ATP binding site [chemical binding]; other site 198628009790 Q-loop/lid; other site 198628009791 ABC transporter signature motif; other site 198628009792 Walker B; other site 198628009793 D-loop; other site 198628009794 H-loop/switch region; other site 198628009795 ABC-type phosphate transport system, auxiliary component [Inorganic ion transport and metabolism]; Region: COG4985 198628009796 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 198628009797 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198628009798 dimer interface [polypeptide binding]; other site 198628009799 conserved gate region; other site 198628009800 putative PBP binding loops; other site 198628009801 ABC-ATPase subunit interface; other site 198628009802 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4590 198628009803 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198628009804 ABC-ATPase subunit interface; other site 198628009805 polyphosphate kinase; Provisional; Region: PRK05443 198628009806 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 198628009807 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 198628009808 Catalytic C-terminal domain, first repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C1_like; cd09164 198628009809 domain interface [polypeptide binding]; other site 198628009810 active site 198628009811 catalytic site [active] 198628009812 Catalytic C-terminal domain, second repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C2_like; cd09167 198628009813 domain interface [polypeptide binding]; other site 198628009814 active site 198628009815 catalytic site [active] 198628009816 exopolyphosphatase; Provisional; Region: PRK10854 198628009817 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 198628009818 nucleotide binding site [chemical binding]; other site 198628009819 hypothetical protein; Provisional; Region: PRK11019 198628009820 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 198628009821 Ligand Binding Site [chemical binding]; other site 198628009822 Domain of unknown function (DUF4186); Region: DUF4186; pfam13811 198628009823 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 198628009824 Isochorismatase family; Region: Isochorismatase; pfam00857 198628009825 catalytic triad [active] 198628009826 conserved cis-peptide bond; other site 198628009827 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 198628009828 YccA-like proteins; Region: YccA_like; cd10433 198628009829 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920 198628009830 sulfur relay protein, TusE/DsrC/DsvC family; Region: dsrC_tusE_dsvC; TIGR03342 198628009831 acylphosphatase; Provisional; Region: PRK14426 198628009832 heat shock protein HspQ; Provisional; Region: PRK14129 198628009833 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 198628009834 hypothetical protein; Provisional; Region: PRK03641 198628009835 Uncharacterized protein conserved in bacteria (DUF2057); Region: DUF2057; cl11437 198628009836 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 198628009837 active site 198628009838 dimer interfaces [polypeptide binding]; other site 198628009839 catalytic residues [active] 198628009840 DNA helicase IV; Provisional; Region: helD; PRK11054 198628009841 DNA helicase IV / RNA helicase N terminal; Region: Nucleolin_N; pfam12462 198628009842 Part of AAA domain; Region: AAA_19; pfam13245 198628009843 Family description; Region: UvrD_C_2; pfam13538 198628009844 hypothetical protein; Provisional; Region: PRK11770 198628009845 Domain of unknown function (DUF307); Region: DUF307; pfam03733 198628009846 Domain of unknown function (DUF307); Region: DUF307; pfam03733 198628009847 TIGR01666 family membrane protein; Region: YCCS 198628009848 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 198628009849 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 198628009850 TfoX N-terminal domain; Region: TfoX_N; pfam04993 198628009851 TfoX C-terminal domain; Region: TfoX_C; pfam04994 198628009852 SOS cell division inhibitor; Provisional; Region: PRK10595 198628009853 outer membrane protein A; Reviewed; Region: PRK10808 198628009854 OmpA-like transmembrane domain; Region: OmpA_membrane; pfam01389 198628009855 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 198628009856 ligand binding site [chemical binding]; other site 198628009857 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 198628009858 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 198628009859 active site 198628009860 catalytic tetrad [active] 198628009861 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 198628009862 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 198628009863 Nucleoside recognition; Region: Gate; pfam07670 198628009864 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 198628009865 multidrug efflux system subunit MdtA; Provisional; Region: PRK11556 198628009866 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 198628009867 HlyD family secretion protein; Region: HlyD_3; pfam13437 198628009868 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 198628009869 Protein export membrane protein; Region: SecD_SecF; cl14618 198628009870 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 198628009871 putative transporter; Provisional; Region: PRK10504 198628009872 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198628009873 putative substrate translocation pore; other site 198628009874 signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549 198628009875 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 198628009876 dimerization interface [polypeptide binding]; other site 198628009877 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 198628009878 dimer interface [polypeptide binding]; other site 198628009879 phosphorylation site [posttranslational modification] 198628009880 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 198628009881 ATP binding site [chemical binding]; other site 198628009882 Mg2+ binding site [ion binding]; other site 198628009883 G-X-G motif; other site 198628009884 DNA-binding transcriptional regulator BaeR; Provisional; Region: PRK10710 198628009885 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 198628009886 active site 198628009887 phosphorylation site [posttranslational modification] 198628009888 intermolecular recognition site; other site 198628009889 dimerization interface [polypeptide binding]; other site 198628009890 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 198628009891 DNA binding site [nucleotide binding] 198628009892 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 198628009893 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 198628009894 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 198628009895 putative dimer interface [polypeptide binding]; other site 198628009896 N-terminal domain interface [polypeptide binding]; other site 198628009897 putative substrate binding pocket (H-site) [chemical binding]; other site 198628009898 putative protease; Provisional; Region: PRK15452 198628009899 Peptidase family U32; Region: Peptidase_U32; pfam01136 198628009900 phosphate-starvation-inducible protein PsiE; Provisional; Region: PRK02833 198628009901 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 198628009902 Nucleoside H+ symporter; Region: Nuc_H_symport; pfam03825 198628009903 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198628009904 putative substrate translocation pore; other site 198628009905 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 198628009906 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 198628009907 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 198628009908 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 198628009909 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 198628009910 Transcriptional regulators [Transcription]; Region: PurR; COG1609 198628009911 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 198628009912 DNA binding site [nucleotide binding] 198628009913 domain linker motif; other site 198628009914 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 198628009915 dimerization interface [polypeptide binding]; other site 198628009916 ligand binding site [chemical binding]; other site 198628009917 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 198628009918 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 198628009919 dimer interface [polypeptide binding]; other site 198628009920 substrate binding site [chemical binding]; other site 198628009921 ATP binding site [chemical binding]; other site 198628009922 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 198628009923 substrate binding site [chemical binding]; other site 198628009924 multimerization interface [polypeptide binding]; other site 198628009925 ATP binding site [chemical binding]; other site 198628009926 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 198628009927 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 198628009928 substrate binding pocket [chemical binding]; other site 198628009929 membrane-bound complex binding site; other site 198628009930 hinge residues; other site 198628009931 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 198628009932 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198628009933 dimer interface [polypeptide binding]; other site 198628009934 conserved gate region; other site 198628009935 putative PBP binding loops; other site 198628009936 ABC-ATPase subunit interface; other site 198628009937 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 198628009938 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 198628009939 Walker A/P-loop; other site 198628009940 ATP binding site [chemical binding]; other site 198628009941 Q-loop/lid; other site 198628009942 ABC transporter signature motif; other site 198628009943 Walker B; other site 198628009944 D-loop; other site 198628009945 H-loop/switch region; other site 198628009946 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 198628009947 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198628009948 dimer interface [polypeptide binding]; other site 198628009949 conserved gate region; other site 198628009950 putative PBP binding loops; other site 198628009951 ABC-ATPase subunit interface; other site 198628009952 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 198628009953 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 198628009954 Protein of unknown function (DUF3750); Region: DUF3750; pfam12570 198628009955 Alginate Lyase A1-III; enzymatically depolymerizes alginate, a complex copolymer of beta-D-mannuronate and alpha-L-guluronate, by cleaving the beta-(1,4) glycosidic bond; Region: AlgLyase; cl00179 198628009956 Fascin-like domain; members include actin-bundling/crosslinking proteins facsin, histoactophilin and singed; identified in sea urchin, Drosophila, Xenopus, rodents, and humans; The fascin-like domain adopts a beta-trefoil topology and contains an...; Region: Fascin; cl00187 198628009957 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 198628009958 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 198628009959 Winged helix-turn-helix DNA-binding; Region: HTH_35; cl17423 198628009960 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 198628009961 GMP synthase; Reviewed; Region: guaA; PRK00074 198628009962 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 198628009963 AMP/PPi binding site [chemical binding]; other site 198628009964 candidate oxyanion hole; other site 198628009965 catalytic triad [active] 198628009966 potential glutamine specificity residues [chemical binding]; other site 198628009967 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 198628009968 ATP Binding subdomain [chemical binding]; other site 198628009969 Ligand Binding sites [chemical binding]; other site 198628009970 Dimerization subdomain; other site 198628009971 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 198628009972 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 198628009973 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 198628009974 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 198628009975 active site 198628009976 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 198628009977 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 198628009978 generic binding surface II; other site 198628009979 generic binding surface I; other site 198628009980 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 198628009981 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 198628009982 active site 198628009983 Zn binding site [ion binding]; other site 198628009984 Protein of unknown function (DUF1407); Region: DUF1407; pfam07191 198628009985 GTP-binding protein Der; Reviewed; Region: PRK00093 198628009986 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 198628009987 G1 box; other site 198628009988 GTP/Mg2+ binding site [chemical binding]; other site 198628009989 Switch I region; other site 198628009990 G2 box; other site 198628009991 Switch II region; other site 198628009992 G3 box; other site 198628009993 G4 box; other site 198628009994 G5 box; other site 198628009995 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 198628009996 G1 box; other site 198628009997 GTP/Mg2+ binding site [chemical binding]; other site 198628009998 Switch I region; other site 198628009999 G2 box; other site 198628010000 G3 box; other site 198628010001 Switch II region; other site 198628010002 G4 box; other site 198628010003 G5 box; other site 198628010004 outer membrane biogenesis protein BamB; Provisional; Region: PRK11138 198628010005 Beta-barrel assembly machinery (Bam) complex component B and related proteins; Region: BamB_YfgL; cd10276 198628010006 Trp docking motif [polypeptide binding]; other site 198628010007 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 198628010008 Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976 198628010009 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 198628010010 binding surface 198628010011 TPR motif; other site 198628010012 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 198628010013 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 198628010014 dimer interface [polypeptide binding]; other site 198628010015 motif 1; other site 198628010016 active site 198628010017 motif 2; other site 198628010018 motif 3; other site 198628010019 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 198628010020 anticodon binding site; other site 198628010021 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 198628010022 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 198628010023 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 198628010024 cytoskeletal protein RodZ; Provisional; Region: PRK10856 198628010025 Helix-turn-helix domain; Region: HTH_25; pfam13413 198628010026 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 198628010027 Tfp pilus assembly protein PilF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilF; COG3063 198628010028 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 198628010029 binding surface 198628010030 TPR motif; other site 198628010031 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 198628010032 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 198628010033 FeS/SAM binding site; other site 198628010034 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 198628010035 active site 198628010036 multimer interface [polypeptide binding]; other site 198628010037 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 198628010038 active site residue [active] 198628010039 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 198628010040 active site residue [active] 198628010041 enhanced serine sensitivity protein SseB; Provisional; Region: PRK11611 198628010042 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 198628010043 Transposase; Region: DEDD_Tnp_IS110; pfam01548 198628010044 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 198628010045 aminopeptidase B; Provisional; Region: PRK05015 198628010046 Peptidase; Region: DUF3663; pfam12404 198628010047 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 198628010048 interface (dimer of trimers) [polypeptide binding]; other site 198628010049 Substrate-binding/catalytic site; other site 198628010050 Zn-binding sites [ion binding]; other site 198628010051 hypothetical protein; Provisional; Region: PRK10721 198628010052 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 198628010053 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 198628010054 catalytic loop [active] 198628010055 iron binding site [ion binding]; other site 198628010056 chaperone protein HscA; Provisional; Region: hscA; PRK05183 198628010057 Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236 198628010058 nucleotide binding site [chemical binding]; other site 198628010059 putative NEF/HSP70 interaction site [polypeptide binding]; other site 198628010060 SBD interface [polypeptide binding]; other site 198628010061 co-chaperone HscB; Provisional; Region: hscB; PRK05014 198628010062 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 198628010063 HSP70 interaction site [polypeptide binding]; other site 198628010064 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743 198628010065 iron-sulfur cluster assembly protein; Provisional; Region: iscA; PRK09502 198628010066 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 198628010067 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 198628010068 trimerization site [polypeptide binding]; other site 198628010069 active site 198628010070 cysteine desulfurase; Provisional; Region: PRK14012 198628010071 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 198628010072 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 198628010073 catalytic residue [active] 198628010074 DNA-binding transcriptional regulator IscR; Provisional; Region: PRK10857 198628010075 Rrf2 family protein; Region: rrf2_super; TIGR00738 198628010076 tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ; Provisional; Region: PRK15114 198628010077 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 198628010078 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 198628010079 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 198628010080 active site 198628010081 dimerization interface [polypeptide binding]; other site 198628010082 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 198628010083 intersubunit interface [polypeptide binding]; other site 198628010084 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 198628010085 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 198628010086 dimer interface [polypeptide binding]; other site 198628010087 putative PBP binding regions; other site 198628010088 ABC-ATPase subunit interface; other site 198628010089 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 198628010090 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 198628010091 Walker A/P-loop; other site 198628010092 ATP binding site [chemical binding]; other site 198628010093 Q-loop/lid; other site 198628010094 ABC transporter signature motif; other site 198628010095 Walker B; other site 198628010096 D-loop; other site 198628010097 H-loop/switch region; other site 198628010098 ferrichrome/ferrioxamine B periplasmic transporter; Provisional; Region: PRK14048 198628010099 Periplasmic binding protein TroA_f. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_f; cd01139 198628010100 putative ligand binding residues [chemical binding]; other site 198628010101 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG2215 198628010102 Protein of unknown function (DUF1007); Region: DUF1007; pfam06226 198628010103 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 198628010104 MFS_1 like family; Region: MFS_1_like; pfam12832 198628010105 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 198628010106 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 198628010107 dimer interface [polypeptide binding]; other site 198628010108 active site 198628010109 glycine-pyridoxal phosphate binding site [chemical binding]; other site 198628010110 folate binding site [chemical binding]; other site 198628010111 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 198628010112 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 198628010113 heme-binding site [chemical binding]; other site 198628010114 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 198628010115 FAD binding pocket [chemical binding]; other site 198628010116 FAD binding motif [chemical binding]; other site 198628010117 phosphate binding motif [ion binding]; other site 198628010118 beta-alpha-beta structure motif; other site 198628010119 NAD binding pocket [chemical binding]; other site 198628010120 Heme binding pocket [chemical binding]; other site 198628010121 Pectate lyase [Carbohydrate transport and metabolism]; Region: PelB; COG3866 198628010122 Pectate lyase; Region: Pec_lyase_C; pfam00544 198628010123 Pectate lyase; Region: Pec_lyase_C; pfam00544 198628010124 Pectate lyase; Region: Pec_lyase_C; pfam00544 198628010125 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 198628010126 active site 198628010127 catalytic triad [active] 198628010128 oxyanion hole [active] 198628010129 Pectinesterase; Region: Pectinesterase; pfam01095 198628010130 putative pectinesterase; Region: PLN02432; cl01911 198628010131 nitrogen regulatory protein P-II 1; Provisional; Region: PRK10858 198628010132 Nitrogen regulatory protein P-II; Region: P-II; smart00938 198628010133 response regulator GlrR; Provisional; Region: PRK15115 198628010134 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 198628010135 active site 198628010136 phosphorylation site [posttranslational modification] 198628010137 intermolecular recognition site; other site 198628010138 dimerization interface [polypeptide binding]; other site 198628010139 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 198628010140 Walker A motif; other site 198628010141 ATP binding site [chemical binding]; other site 198628010142 Walker B motif; other site 198628010143 arginine finger; other site 198628010144 hypothetical protein; Provisional; Region: PRK10722 198628010145 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 198628010146 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 198628010147 dimer interface [polypeptide binding]; other site 198628010148 phosphorylation site [posttranslational modification] 198628010149 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 198628010150 ATP binding site [chemical binding]; other site 198628010151 Mg2+ binding site [ion binding]; other site 198628010152 G-X-G motif; other site 198628010153 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 198628010154 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 198628010155 dimerization interface [polypeptide binding]; other site 198628010156 ATP binding site [chemical binding]; other site 198628010157 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 198628010158 dimerization interface [polypeptide binding]; other site 198628010159 ATP binding site [chemical binding]; other site 198628010160 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 198628010161 putative active site [active] 198628010162 catalytic triad [active] 198628010163 membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859 198628010164 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 198628010165 substrate binding pocket [chemical binding]; other site 198628010166 membrane-bound complex binding site; other site 198628010167 hinge residues; other site 198628010168 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 198628010169 N-acetyl-D-glucosamine binding site [chemical binding]; other site 198628010170 catalytic residue [active] 198628010171 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 198628010172 nucleoside/Zn binding site; other site 198628010173 dimer interface [polypeptide binding]; other site 198628010174 catalytic motif [active] 198628010175 hypothetical protein; Provisional; Region: PRK11590 198628010176 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 198628010177 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 198628010178 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 198628010179 putative active site [active] 198628010180 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39_likeD; cd02421 198628010181 type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375 198628010182 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 198628010183 ATP-binding cassette domain of bacteriocin exporters, subfamily C; Region: ABCC_bacteriocin_exporters; cd03245 198628010184 Walker A/P-loop; other site 198628010185 ATP binding site [chemical binding]; other site 198628010186 Q-loop/lid; other site 198628010187 ABC transporter signature motif; other site 198628010188 Walker B; other site 198628010189 D-loop; other site 198628010190 H-loop/switch region; other site 198628010191 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 198628010192 lipoyl-biotinyl attachment site [posttranslational modification]; other site 198628010193 HlyD family secretion protein; Region: HlyD_3; pfam13437 198628010194 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 198628010195 PAS domain; Region: PAS_9; pfam13426 198628010196 putative active site [active] 198628010197 heme pocket [chemical binding]; other site 198628010198 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 198628010199 GAF domain; Region: GAF; pfam01590 198628010200 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 198628010201 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 198628010202 metal binding site [ion binding]; metal-binding site 198628010203 active site 198628010204 I-site; other site 198628010205 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 198628010206 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 198628010207 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 198628010208 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 198628010209 active site 198628010210 hydrophilic channel; other site 198628010211 dimerization interface [polypeptide binding]; other site 198628010212 catalytic residues [active] 198628010213 active site lid [active] 198628010214 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 198628010215 Recombination protein O N terminal; Region: RecO_N; pfam11967 198628010216 Recombination protein O C terminal; Region: RecO_C; pfam02565 198628010217 GTPase Era; Reviewed; Region: era; PRK00089 198628010218 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 198628010219 G1 box; other site 198628010220 GTP/Mg2+ binding site [chemical binding]; other site 198628010221 Switch I region; other site 198628010222 G2 box; other site 198628010223 Switch II region; other site 198628010224 G3 box; other site 198628010225 G4 box; other site 198628010226 G5 box; other site 198628010227 KH domain; Region: KH_2; pfam07650 198628010228 ribonuclease III; Reviewed; Region: rnc; PRK00102 198628010229 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 198628010230 dimerization interface [polypeptide binding]; other site 198628010231 active site 198628010232 metal binding site [ion binding]; metal-binding site 198628010233 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 198628010234 dsRNA binding site [nucleotide binding]; other site 198628010235 signal peptidase I; Provisional; Region: PRK10861 198628010236 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 198628010237 Catalytic site [active] 198628010238 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 198628010239 GTP-binding protein LepA; Provisional; Region: PRK05433 198628010240 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 198628010241 G1 box; other site 198628010242 putative GEF interaction site [polypeptide binding]; other site 198628010243 GTP/Mg2+ binding site [chemical binding]; other site 198628010244 Switch I region; other site 198628010245 G2 box; other site 198628010246 G3 box; other site 198628010247 Switch II region; other site 198628010248 G4 box; other site 198628010249 G5 box; other site 198628010250 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 198628010251 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 198628010252 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 198628010253 Positive regulator of sigma(E), RseC/MucC; Region: RseC_MucC; cl01178 198628010254 anti-sigma E factor; Provisional; Region: rseB; PRK09455 198628010255 Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026 198628010256 anti-RNA polymerase sigma factor SigE; Provisional; Region: PRK10863 198628010257 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 198628010258 Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873 198628010259 RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939 198628010260 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 198628010261 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 198628010262 DNA binding residues [nucleotide binding] 198628010263 L-aspartate oxidase; Provisional; Region: PRK09077 198628010264 L-aspartate oxidase; Provisional; Region: PRK06175 198628010265 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 198628010266 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 198628010267 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 198628010268 S-adenosylmethionine binding site [chemical binding]; other site 198628010269 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 198628010270 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 198628010271 ATP binding site [chemical binding]; other site 198628010272 Mg++ binding site [ion binding]; other site 198628010273 motif III; other site 198628010274 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 198628010275 nucleotide binding region [chemical binding]; other site 198628010276 ATP-binding site [chemical binding]; other site 198628010277 autonomous glycyl radical cofactor GrcA; Provisional; Region: PRK11127 198628010278 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 198628010279 ligand binding site [chemical binding]; other site 198628010280 active site 198628010281 UGI interface [polypeptide binding]; other site 198628010282 catalytic site [active] 198628010283 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 198628010284 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 198628010285 active site 198628010286 HIGH motif; other site 198628010287 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 198628010288 active site 198628010289 KMSKS motif; other site 198628010290 DoxX; Region: DoxX; pfam07681 198628010291 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 198628010292 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 198628010293 Walker A/P-loop; other site 198628010294 ATP binding site [chemical binding]; other site 198628010295 Q-loop/lid; other site 198628010296 ABC transporter signature motif; other site 198628010297 Walker B; other site 198628010298 D-loop; other site 198628010299 H-loop/switch region; other site 198628010300 TOBE-like domain; Region: TOBE_3; pfam12857 198628010301 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 198628010302 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198628010303 dimer interface [polypeptide binding]; other site 198628010304 conserved gate region; other site 198628010305 putative PBP binding loops; other site 198628010306 ABC-ATPase subunit interface; other site 198628010307 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 198628010308 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198628010309 dimer interface [polypeptide binding]; other site 198628010310 conserved gate region; other site 198628010311 putative PBP binding loops; other site 198628010312 ABC-ATPase subunit interface; other site 198628010313 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 198628010314 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 198628010315 substrate binding pocket [chemical binding]; other site 198628010316 membrane-bound complex binding site; other site 198628010317 hinge residues; other site 198628010318 carbohydrate diacid transcriptional activator CdaR; Provisional; Region: PRK11477 198628010319 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 198628010320 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 198628010321 serine endoprotease; Provisional; Region: PRK10942 198628010322 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 198628010323 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 198628010324 protein binding site [polypeptide binding]; other site 198628010325 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 198628010326 deoxyguanosinetriphosphate triphosphohydrolase; Provisional; Region: dgt; PRK04926 198628010327 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 198628010328 Zn2+ binding site [ion binding]; other site 198628010329 Mg2+ binding site [ion binding]; other site 198628010330 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 198628010331 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 198628010332 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 198628010333 vitamin B12-transporter protein BtuF; Provisional; Region: PRK03379 198628010334 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 198628010335 cobalamin binding residues [chemical binding]; other site 198628010336 putative BtuC binding residues; other site 198628010337 dimer interface [polypeptide binding]; other site 198628010338 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 198628010339 Transposase; Region: DEDD_Tnp_IS110; pfam01548 198628010340 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 198628010341 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 198628010342 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 198628010343 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 198628010344 Cl- selectivity filter; other site 198628010345 Cl- binding residues [ion binding]; other site 198628010346 pore gating glutamate residue; other site 198628010347 dimer interface [polypeptide binding]; other site 198628010348 H+/Cl- coupling transport residue; other site 198628010349 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 198628010350 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 198628010351 inhibitor-cofactor binding pocket; inhibition site 198628010352 pyridoxal 5'-phosphate binding site [chemical binding]; other site 198628010353 catalytic residue [active] 198628010354 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 198628010355 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 198628010356 ABC-ATPase subunit interface; other site 198628010357 dimer interface [polypeptide binding]; other site 198628010358 putative PBP binding regions; other site 198628010359 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 198628010360 ABC-ATPase subunit interface; other site 198628010361 dimer interface [polypeptide binding]; other site 198628010362 putative PBP binding regions; other site 198628010363 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 198628010364 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 198628010365 siderophore binding site; other site 198628010366 iron-hydroxamate transporter ATP-binding subunit; Provisional; Region: PRK10575 198628010367 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 198628010368 Walker A/P-loop; other site 198628010369 ATP binding site [chemical binding]; other site 198628010370 Q-loop/lid; other site 198628010371 ABC transporter signature motif; other site 198628010372 Walker B; other site 198628010373 D-loop; other site 198628010374 H-loop/switch region; other site 198628010375 bifunctional glycosyl transferase/transpeptidase; Reviewed; Region: mrcB; PRK09506 198628010376 Transglycosylase; Region: Transgly; pfam00912 198628010377 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 198628010378 ATP-dependent RNA helicase HrpB; Provisional; Region: PRK11664 198628010379 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 198628010380 ATP binding site [chemical binding]; other site 198628010381 putative Mg++ binding site [ion binding]; other site 198628010382 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 198628010383 nucleotide binding region [chemical binding]; other site 198628010384 ATP-binding site [chemical binding]; other site 198628010385 Helicase associated domain (HA2) Add an annotation; Region: HA2; smart00847 198628010386 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 198628010387 2'-5' RNA ligase; Provisional; Region: PRK15124 198628010388 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 198628010389 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 198628010390 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 198628010391 RNA polymerase-binding transcription factor; Provisional; Region: dksA; PRK10778 198628010392 Glutamyl- and glutaminyl-tRNA synthetases [Translation, ribosomal structure and biogenesis]; Region: GlnS; COG0008 198628010393 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 198628010394 active site 198628010395 nucleotide binding site [chemical binding]; other site 198628010396 HIGH motif; other site 198628010397 KMSKS motif; other site 198628010398 poly(A) polymerase I; Provisional; Region: pcnB; PRK11623 198628010399 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 198628010400 active site 198628010401 NTP binding site [chemical binding]; other site 198628010402 metal binding triad [ion binding]; metal-binding site 198628010403 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 198628010404 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 198628010405 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 198628010406 catalytic center binding site [active] 198628010407 ATP binding site [chemical binding]; other site 198628010408 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 198628010409 oligomerization interface [polypeptide binding]; other site 198628010410 active site 198628010411 metal binding site [ion binding]; metal-binding site 198628010412 Pantoate-beta-alanine ligase; Region: PanC; cd00560 198628010413 pantoate--beta-alanine ligase; Region: panC; TIGR00018 198628010414 active site 198628010415 ATP-binding site [chemical binding]; other site 198628010416 pantoate-binding site; other site 198628010417 HXXH motif; other site 198628010418 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 198628010419 tetramerization interface [polypeptide binding]; other site 198628010420 active site 198628010421 inner membrane transport permease; Provisional; Region: PRK15066 198628010422 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 198628010423 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 198628010424 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 198628010425 Walker A/P-loop; other site 198628010426 ATP binding site [chemical binding]; other site 198628010427 Q-loop/lid; other site 198628010428 ABC transporter signature motif; other site 198628010429 Walker B; other site 198628010430 D-loop; other site 198628010431 H-loop/switch region; other site 198628010432 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 198628010433 active site clefts [active] 198628010434 zinc binding site [ion binding]; other site 198628010435 dimer interface [polypeptide binding]; other site 198628010436 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 198628010437 active site 198628010438 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 198628010439 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 198628010440 Coenzyme A binding pocket [chemical binding]; other site 198628010441 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 198628010442 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 198628010443 Walker A/P-loop; other site 198628010444 ATP binding site [chemical binding]; other site 198628010445 Q-loop/lid; other site 198628010446 ABC transporter signature motif; other site 198628010447 Walker B; other site 198628010448 D-loop; other site 198628010449 H-loop/switch region; other site 198628010450 TOBE domain; Region: TOBE_2; pfam08402 198628010451 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 198628010452 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198628010453 dimer interface [polypeptide binding]; other site 198628010454 conserved gate region; other site 198628010455 putative PBP binding loops; other site 198628010456 ABC-ATPase subunit interface; other site 198628010457 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 198628010458 Bacterial chaperone lipoprotein (PulS_OutS); Region: PulS_OutS; cl09898 198628010459 spermidine synthase; Provisional; Region: PRK00811 198628010460 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 198628010461 S-adenosylmethionine binding site [chemical binding]; other site 198628010462 S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462 198628010463 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 198628010464 catalytic residues [active] 198628010465 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 198628010466 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 198628010467 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 198628010468 Class I ribonucleotide reductase; Region: RNR_I; cd01679 198628010469 active site 198628010470 dimer interface [polypeptide binding]; other site 198628010471 catalytic residues [active] 198628010472 effector binding site; other site 198628010473 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 198628010474 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 198628010475 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 198628010476 dimer interface [polypeptide binding]; other site 198628010477 putative radical transfer pathway; other site 198628010478 diiron center [ion binding]; other site 198628010479 tyrosyl radical; other site 198628010480 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 198628010481 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 198628010482 active site 198628010483 catalytic site [active] 198628010484 substrate binding site [chemical binding]; other site 198628010485 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 198628010486 RNA/DNA hybrid binding site [nucleotide binding]; other site 198628010487 active site 198628010488 Methyltransferase domain; Region: Methyltransf_11; pfam08241 198628010489 hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413 198628010490 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 198628010491 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 198628010492 N-acetyl-D-glucosamine binding site [chemical binding]; other site 198628010493 catalytic residue [active] 198628010494 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 198628010495 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 198628010496 hypothetical protein; Provisional; Region: PRK05421 198628010497 putative catalytic site [active] 198628010498 putative metal binding site [ion binding]; other site 198628010499 putative catalytic site [active] 198628010500 putative phosphate binding site [ion binding]; other site 198628010501 putative phosphate binding site [ion binding]; other site 198628010502 putative metal binding site [ion binding]; other site 198628010503 protein disaggregation chaperone; Provisional; Region: PRK10865 198628010504 Clp amino terminal domain; Region: Clp_N; pfam02861 198628010505 Clp amino terminal domain; Region: Clp_N; pfam02861 198628010506 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 198628010507 Walker A motif; other site 198628010508 ATP binding site [chemical binding]; other site 198628010509 Walker B motif; other site 198628010510 arginine finger; other site 198628010511 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 198628010512 Walker A motif; other site 198628010513 ATP binding site [chemical binding]; other site 198628010514 Walker B motif; other site 198628010515 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 198628010516 hypothetical protein; Provisional; Region: PRK10723 198628010517 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 198628010518 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 198628010519 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 198628010520 RNA binding surface [nucleotide binding]; other site 198628010521 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 198628010522 active site 198628010523 outer membrane biogenesis protein BamD; Provisional; Region: PRK10866 198628010524 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 198628010525 30S subunit binding site; other site 198628010526 bifunctional chorismate mutase/prephenate dehydratase; Provisional; Region: pheA; PRK10622 198628010527 chorismate mutase domain of proteobacterial P-protein, clade 1; Region: CM_P_1; TIGR01797 198628010528 Prephenate dehydratase; Region: PDT; pfam00800 198628010529 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 198628010530 putative L-Phe binding site [chemical binding]; other site 198628010531 bifunctional chorismate mutase/prephenate dehydrogenase; Provisional; Region: tyrA; PRK11199 198628010532 Chorismate mutase type II; Region: CM_2; cl00693 198628010533 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 198628010534 prephenate dehydrogenase; Validated; Region: PRK08507 198628010535 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 198628010536 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 198628010537 lipoprotein; Provisional; Region: PRK11443 198628010538 Protein of unknown function (DUF2799); Region: DUF2799; pfam10973 198628010539 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 198628010541 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 198628010542 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 198628010543 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 198628010544 RimM N-terminal domain; Region: RimM; pfam01782 198628010545 PRC-barrel domain; Region: PRC; pfam05239 198628010546 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 198628010547 signal recognition particle protein; Provisional; Region: PRK10867 198628010548 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 198628010549 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 198628010550 P loop; other site 198628010551 GTP binding site [chemical binding]; other site 198628010552 Signal peptide binding domain; Region: SRP_SPB; pfam02978 198628010553 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4137 198628010554 S-ribosylhomocysteinase; Provisional; Region: PRK02260 198628010555 glutamate--cysteine ligase; Provisional; Region: PRK02107 198628010556 Predicted membrane protein [Function unknown]; Region: COG1238 198628010557 fructose-1-P/6-phosphogluconate phosphatase; Provisional; Region: PRK10725 198628010558 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 198628010559 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 198628010560 motif II; other site 198628010561 carbon storage regulator; Provisional; Region: PRK01712 198628010562 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 198628010563 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 198628010564 motif 1; other site 198628010565 active site 198628010566 motif 2; other site 198628010567 motif 3; other site 198628010568 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 198628010569 DHHA1 domain; Region: DHHA1; pfam02272 198628010570 recombination regulator RecX; Reviewed; Region: recX; PRK00117 198628010571 recombinase A; Provisional; Region: recA; PRK09354 198628010572 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 198628010573 hexamer interface [polypeptide binding]; other site 198628010574 Walker A motif; other site 198628010575 ATP binding site [chemical binding]; other site 198628010576 Walker B motif; other site 198628010577 hypothetical protein; Validated; Region: PRK03661 198628010578 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 198628010579 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 198628010580 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 198628010581 putative hydrophobic ligand binding site [chemical binding]; other site 198628010582 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 198628010583 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 198628010584 acetoin reductase; Validated; Region: PRK08643 198628010585 meso-2,3-butanediol dehydrogenase-like, classical (c) SDRs; Region: meso-BDH-like_SDR_c; cd05366 198628010586 NAD binding site [chemical binding]; other site 198628010587 homotetramer interface [polypeptide binding]; other site 198628010588 homodimer interface [polypeptide binding]; other site 198628010589 active site 198628010590 substrate binding site [chemical binding]; other site 198628010591 Transcriptional regulators [Transcription]; Region: MarR; COG1846 198628010592 MarR family; Region: MarR; pfam01047 198628010593 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 198628010594 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 198628010595 tetramer interface [polypeptide binding]; other site 198628010596 heme binding pocket [chemical binding]; other site 198628010597 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 198628010598 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 198628010599 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 198628010600 Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309 198628010601 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 198628010602 putative ligand binding site [chemical binding]; other site 198628010603 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 198628010604 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 198628010605 Walker A/P-loop; other site 198628010606 ATP binding site [chemical binding]; other site 198628010607 Q-loop/lid; other site 198628010608 ABC transporter signature motif; other site 198628010609 Walker B; other site 198628010610 D-loop; other site 198628010611 H-loop/switch region; other site 198628010612 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 198628010613 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 198628010614 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 198628010615 TM-ABC transporter signature motif; other site 198628010616 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 198628010617 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 198628010618 TM-ABC transporter signature motif; other site 198628010619 Phophatidylserine decarboxylase; Region: PSDC; pfam12588 198628010620 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; pfam02666 198628010621 Peptidase family C69; Region: Peptidase_C69; cl17793 198628010622 Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121 198628010623 putative catalytic cysteine [active] 198628010624 transcriptional regulator EutR; Provisional; Region: PRK10130 198628010625 putative GTP-binding protein YjiA; Provisional; Region: PRK11537 198628010626 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 198628010627 P-loop, Walker A motif; other site 198628010628 Base recognition motif; other site 198628010629 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 198628010630 Uncharacterized small protein [Function unknown]; Region: COG2879 198628010631 carbon starvation protein A; Provisional; Region: PRK15015 198628010632 Carbon starvation protein CstA; Region: CstA; pfam02554 198628010633 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 198628010634 putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697 198628010635 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 198628010636 active site 198628010637 phosphorylation site [posttranslational modification] 198628010638 intermolecular recognition site; other site 198628010639 dimerization interface [polypeptide binding]; other site 198628010640 LytTr DNA-binding domain; Region: LytTR; pfam04397 198628010641 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 198628010642 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 198628010643 GAF domain; Region: GAF; pfam01590 198628010644 Histidine kinase; Region: His_kinase; pfam06580 198628010645 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 198628010646 ATP binding site [chemical binding]; other site 198628010647 Mg2+ binding site [ion binding]; other site 198628010648 G-X-G motif; other site 198628010649 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 198628010650 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 198628010651 DNA-binding site [nucleotide binding]; DNA binding site 198628010652 UTRA domain; Region: UTRA; pfam07702 198628010653 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08651 198628010654 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 198628010655 metal binding site [ion binding]; metal-binding site 198628010656 dimer interface [polypeptide binding]; other site 198628010657 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 198628010658 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 198628010659 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 198628010660 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198628010661 dimer interface [polypeptide binding]; other site 198628010662 conserved gate region; other site 198628010663 putative PBP binding loops; other site 198628010664 ABC-ATPase subunit interface; other site 198628010665 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 198628010666 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198628010667 dimer interface [polypeptide binding]; other site 198628010668 conserved gate region; other site 198628010669 putative PBP binding loops; other site 198628010670 ABC-ATPase subunit interface; other site 198628010671 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 198628010672 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 198628010673 Walker A/P-loop; other site 198628010674 ATP binding site [chemical binding]; other site 198628010675 Q-loop/lid; other site 198628010676 ABC transporter signature motif; other site 198628010677 Walker B; other site 198628010678 D-loop; other site 198628010679 H-loop/switch region; other site 198628010680 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 198628010681 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 198628010682 Walker A/P-loop; other site 198628010683 ATP binding site [chemical binding]; other site 198628010684 Q-loop/lid; other site 198628010685 ABC transporter signature motif; other site 198628010686 Walker B; other site 198628010687 D-loop; other site 198628010688 H-loop/switch region; other site 198628010689 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 198628010690 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 198628010691 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 198628010692 metal binding site [ion binding]; metal-binding site 198628010693 YCII-related domain; Region: YCII; cl00999 198628010694 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 198628010695 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 198628010696 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 198628010697 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 198628010698 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 198628010699 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138 198628010700 conserved cys residue [active] 198628010701 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 198628010702 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 198628010703 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 198628010704 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 198628010705 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 198628010706 acyl-activating enzyme (AAE) consensus motif; other site 198628010707 AMP binding site [chemical binding]; other site 198628010708 MBOAT, membrane-bound O-acyltransferase family; Region: MBOAT; cl00738 198628010709 D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092 198628010710 GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472 198628010711 Toxin YafO, type II toxin-antitoxin system; Region: YafO_toxin; cl08066 198628010712 putative antitoxin of the YafO-YafN toxin-antitoxin system; Provisional; Region: PRK09778 198628010713 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK07111 198628010714 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4643 198628010715 Zinc-binding domain of primase-helicase; Region: Prim_Zn_Ribbon; smart00778 198628010716 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 198628010717 active site 198628010718 metal binding site [ion binding]; metal-binding site 198628010719 interdomain interaction site; other site 198628010720 Superfamily II helicase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG5519 198628010721 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 198628010722 integrase; Provisional; Region: PRK09692 198628010723 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 198628010724 active site 198628010725 Int/Topo IB signature motif; other site 198628010726 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 198628010727 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 198628010728 putative catalytic cysteine [active] 198628010729 gamma-glutamyl kinase; Provisional; Region: PRK05429 198628010730 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 198628010731 nucleotide binding site [chemical binding]; other site 198628010732 homotetrameric interface [polypeptide binding]; other site 198628010733 putative phosphate binding site [ion binding]; other site 198628010734 putative allosteric binding site; other site 198628010735 PUA domain; Region: PUA; pfam01472 198628010736 DNA-binding transcriptional regulator Crl; Provisional; Region: PRK10984 198628010737 putative inner membrane diguanylate cyclase; Provisional; Region: PRK09966 198628010738 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 198628010739 metal binding site [ion binding]; metal-binding site 198628010740 active site 198628010741 I-site; other site 198628010742 Domain of unknown function (DUF4154); Region: DUF4154; pfam13689 198628010743 fermentation/respiration switch protein; Reviewed; Region: frsA; PRK05077 198628010744 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 198628010745 active site 198628010746 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 198628010747 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 198628010748 metal binding site [ion binding]; metal-binding site 198628010749 dimer interface [polypeptide binding]; other site 198628010750 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 198628010751 active site 198628010752 DNA polymerase IV; Validated; Region: PRK02406 198628010753 DNA binding site [nucleotide binding] 198628010754 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 198628010755 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 198628010756 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 198628010757 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 198628010758 putative active site [active] 198628010759 putative dimer interface [polypeptide binding]; other site 198628010760 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 198628010761 active site 198628010762 dimer interface [polypeptide binding]; other site 198628010763 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 198628010764 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 198628010765 active site 198628010766 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 198628010767 methylthioribose kinase; Reviewed; Region: mtnK; PRK09550 198628010768 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 198628010769 S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512 198628010770 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791 198628010771 Cupin domain; Region: Cupin_2; cl17218 198628010772 2,3-diketo-5-methylthio-1-phosphopentane phosphatase; Region: enolase-ppase; TIGR01691 198628010773 methylthioribulose-1-phosphate dehydratase; Provisional; Region: PRK09220 198628010774 intersubunit interface [polypeptide binding]; other site 198628010775 active site 198628010776 Zn2+ binding site [ion binding]; other site 198628010777 methionine aminotransferase; Validated; Region: PRK09082 198628010778 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 198628010779 pyridoxal 5'-phosphate binding site [chemical binding]; other site 198628010780 homodimer interface [polypeptide binding]; other site 198628010781 catalytic residue [active] 198628010782 C-N hydrolase family amidase; Provisional; Region: PRK10438 198628010783 Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575 198628010784 putative active site [active] 198628010785 catalytic triad [active] 198628010786 dimer interface [polypeptide binding]; other site 198628010787 multimer interface [polypeptide binding]; other site 198628010788 allantoate amidohydrolase; Reviewed; Region: PRK09290 198628010789 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 198628010790 active site 198628010791 metal binding site [ion binding]; metal-binding site 198628010792 dimer interface [polypeptide binding]; other site 198628010793 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 198628010794 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 198628010795 catalytic residue [active] 198628010796 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 198628010797 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 198628010798 Walker A/P-loop; other site 198628010799 ATP binding site [chemical binding]; other site 198628010800 Q-loop/lid; other site 198628010801 ABC transporter signature motif; other site 198628010802 Walker B; other site 198628010803 D-loop; other site 198628010804 H-loop/switch region; other site 198628010805 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198628010806 ABC-ATPase subunit interface; other site 198628010807 putative PBP binding loops; other site 198628010808 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198628010809 dimer interface [polypeptide binding]; other site 198628010810 conserved gate region; other site 198628010811 putative PBP binding loops; other site 198628010812 ABC-ATPase subunit interface; other site 198628010813 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 198628010814 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 198628010815 substrate binding pocket [chemical binding]; other site 198628010816 membrane-bound complex binding site; other site 198628010817 hinge residues; other site 198628010818 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 198628010819 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 198628010820 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 198628010821 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 198628010822 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 198628010823 Protein of unknown function (DUF4089); Region: DUF4089; pfam13318 198628010824 amidase; Provisional; Region: PRK09201 198628010825 Amidase; Region: Amidase; cl11426 198628010826 Protein of unknown function (DUF3225); Region: DUF3225; pfam11533 198628010827 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 198628010828 Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977 198628010829 active site 198628010830 catalytic site [active] 198628010831 tetramer interface [polypeptide binding]; other site 198628010832 Hydantoin racemase [Amino acid transport and metabolism]; Region: COG4126 198628010833 Transcriptional regulators [Transcription]; Region: FadR; COG2186 198628010834 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 198628010835 DNA-binding site [nucleotide binding]; DNA binding site 198628010836 FCD domain; Region: FCD; pfam07729 198628010837 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding domain; Region: SLC-NCS1sbd_u1; cd11555 198628010838 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 198628010839 putative substrate binding site [chemical binding]; other site 198628010840 Na binding site [ion binding]; other site 198628010841 allophanate hydrolase; Provisional; Region: PRK08186 198628010842 Amidase; Region: Amidase; pfam01425 198628010843 Transcriptional regulators [Transcription]; Region: FadR; COG2186 198628010844 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 198628010845 DNA-binding site [nucleotide binding]; DNA binding site 198628010846 FCD domain; Region: FCD; pfam07729 198628010847 glycine betaine transporter ATP-binding subunit; Provisional; Region: PRK10070 198628010848 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 198628010849 Walker A/P-loop; other site 198628010850 ATP binding site [chemical binding]; other site 198628010851 Q-loop/lid; other site 198628010852 ABC transporter signature motif; other site 198628010853 Walker B; other site 198628010854 D-loop; other site 198628010855 H-loop/switch region; other site 198628010856 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 198628010857 glycine betaine transporter membrane protein; Provisional; Region: PRK10952 198628010858 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198628010859 dimer interface [polypeptide binding]; other site 198628010860 conserved gate region; other site 198628010861 putative PBP binding loops; other site 198628010862 ABC-ATPase subunit interface; other site 198628010863 glycine betaine transporter periplasmic subunit; Provisional; Region: proX; PRK11119 198628010864 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 198628010865 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 198628010866 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198628010867 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 198628010868 putative L-valine exporter; Provisional; Region: PRK10408 198628010869 transcriptional repressor MprA; Provisional; Region: PRK10870 198628010870 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 198628010871 multidrug efflux system protein EmrA; Provisional; Region: PRK15136 198628010872 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 198628010873 HlyD family secretion protein; Region: HlyD_3; pfam13437 198628010874 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 198628010875 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198628010876 putative substrate translocation pore; other site 198628010877 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198628010878 putative methyltransferase; Provisional; Region: PRK10864 198628010879 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 198628010880 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 198628010881 thioredoxin 2; Provisional; Region: PRK10996 198628010882 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 198628010883 catalytic residues [active] 198628010884 Uncharacterized conserved protein [Function unknown]; Region: COG3148 198628010885 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 198628010886 CoA binding domain; Region: CoA_binding_2; pfam13380 198628010887 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 198628010888 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 198628010889 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 198628010890 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 198628010891 phosphatidylserine synthase; Provisional; Region: pssA; PRK09428 198628010892 Catalytic domain, repeat 1, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_1; cd09134 198628010893 domain interface [polypeptide binding]; other site 198628010894 putative active site [active] 198628010895 catalytic site [active] 198628010896 Catalytic domain, repeat 2, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_2; cd09136 198628010897 domain interface [polypeptide binding]; other site 198628010898 putative active site [active] 198628010899 catalytic site [active] 198628010900 lipoprotein; Provisional; Region: PRK10759 198628010901 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 198628010902 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198628010903 putative substrate translocation pore; other site 198628010904 histidinol-phosphate phosphatase family domain; Region: Histidinol-ppas; TIGR01656 198628010905 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 198628010906 active site 198628010907 motif I; other site 198628010908 motif II; other site 198628010909 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 198628010910 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 198628010911 Walker A/P-loop; other site 198628010912 ATP binding site [chemical binding]; other site 198628010913 Q-loop/lid; other site 198628010914 ABC transporter signature motif; other site 198628010915 Walker B; other site 198628010916 D-loop; other site 198628010917 H-loop/switch region; other site 198628010918 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 198628010919 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198628010920 dimer interface [polypeptide binding]; other site 198628010921 conserved gate region; other site 198628010922 ABC-ATPase subunit interface; other site 198628010923 DL-methionine transporter substrate-binding subunit; Provisional; Region: metQ; PRK11063 198628010924 lipoprotein, YaeC family; Region: TIGR00363 198628010925 outer membrane lipoprotein; Reviewed; Region: rcsF; PRK10781 198628010926 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 198628010927 homodimer interaction site [polypeptide binding]; other site 198628010928 cofactor binding site; other site 198628010929 prolyl-tRNA synthetase; Provisional; Region: PRK09194 198628010930 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 198628010931 dimer interface [polypeptide binding]; other site 198628010932 motif 1; other site 198628010933 active site 198628010934 motif 2; other site 198628010935 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 198628010936 putative deacylase active site [active] 198628010937 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 198628010938 active site 198628010939 motif 3; other site 198628010940 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 198628010941 anticodon binding site; other site 198628010942 RNA polymerase sigma factor RpoS; Validated; Region: PRK05657 198628010943 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 198628010944 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 198628010945 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 198628010946 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 198628010947 DNA binding residues [nucleotide binding] 198628010948 lipoprotein NlpD; Provisional; Region: nlpD; PRK10871 198628010949 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 198628010950 Peptidase family M23; Region: Peptidase_M23; pfam01551 198628010951 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 198628010952 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 198628010953 S-adenosylmethionine binding site [chemical binding]; other site 198628010954 tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984 198628010955 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 198628010956 Permutation of conserved domain; other site 198628010957 active site 198628010958 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 198628010959 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 198628010960 homotrimer interaction site [polypeptide binding]; other site 198628010961 zinc binding site [ion binding]; other site 198628010962 CDP-binding sites; other site 198628010963 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 198628010964 substrate binding site; other site 198628010965 dimer interface; other site 198628010966 cell division protein FtsB; Reviewed; Region: ftsB; PRK00888 198628010967 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 198628010968 hypothetical protein; Provisional; Region: PRK10726 198628010969 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 198628010970 ligand-binding site [chemical binding]; other site 198628010971 sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124 198628010972 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 198628010973 CysD dimerization site [polypeptide binding]; other site 198628010974 G1 box; other site 198628010975 putative GEF interaction site [polypeptide binding]; other site 198628010976 GTP/Mg2+ binding site [chemical binding]; other site 198628010977 Switch I region; other site 198628010978 G2 box; other site 198628010979 G3 box; other site 198628010980 Switch II region; other site 198628010981 G4 box; other site 198628010982 G5 box; other site 198628010983 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 198628010984 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 198628010985 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 198628010986 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 198628010987 Active Sites [active] 198628010988 siroheme synthase; Provisional; Region: cysG; PRK10637 198628010989 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 198628010990 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 198628010991 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 198628010992 active site 198628010993 SAM binding site [chemical binding]; other site 198628010994 homodimer interface [polypeptide binding]; other site 198628010995 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 198628010996 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 198628010997 Active Sites [active] 198628010998 sulfite reductase subunit beta; Provisional; Region: PRK13504 198628010999 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 198628011000 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 198628011001 sulfite reductase subunit alpha; Provisional; Region: cysJ; PRK10953 198628011002 Flavodoxin; Region: Flavodoxin_1; pfam00258 198628011003 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 198628011004 FAD binding pocket [chemical binding]; other site 198628011005 FAD binding motif [chemical binding]; other site 198628011006 catalytic residues [active] 198628011007 NAD binding pocket [chemical binding]; other site 198628011008 phosphate binding motif [ion binding]; other site 198628011009 beta-alpha-beta structure motif; other site 198628011010 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 198628011011 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 198628011012 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 198628011013 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 198628011014 active site 198628011015 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 198628011016 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 198628011017 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 198628011018 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 198628011019 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 198628011020 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 198628011021 Periplasmic binding protein TroA_e. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_e; cd01142 198628011022 putative ligand binding residues [chemical binding]; other site 198628011023 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 198628011024 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 198628011025 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 198628011026 N-terminal plug; other site 198628011027 ligand-binding site [chemical binding]; other site 198628011028 enolase; Provisional; Region: eno; PRK00077 198628011029 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 198628011030 dimer interface [polypeptide binding]; other site 198628011031 metal binding site [ion binding]; metal-binding site 198628011032 substrate binding pocket [chemical binding]; other site 198628011033 CTP synthetase; Validated; Region: pyrG; PRK05380 198628011034 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 198628011035 Catalytic site [active] 198628011036 active site 198628011037 UTP binding site [chemical binding]; other site 198628011038 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 198628011039 active site 198628011040 putative oxyanion hole; other site 198628011041 catalytic triad [active] 198628011042 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 198628011043 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 198628011044 homodimer interface [polypeptide binding]; other site 198628011045 metal binding site [ion binding]; metal-binding site 198628011046 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 198628011047 homodimer interface [polypeptide binding]; other site 198628011048 active site 198628011049 putative chemical substrate binding site [chemical binding]; other site 198628011050 metal binding site [ion binding]; metal-binding site 198628011051 (p)ppGpp synthetase I/GTP pyrophosphokinase; Provisional; Region: relA; PRK10872 198628011052 HD domain; Region: HD_4; pfam13328 198628011053 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 198628011054 synthetase active site [active] 198628011055 NTP binding site [chemical binding]; other site 198628011056 metal binding site [ion binding]; metal-binding site 198628011057 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 198628011058 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 198628011059 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 198628011060 TRAM domain; Region: TRAM; pfam01938 198628011061 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 198628011062 S-adenosylmethionine binding site [chemical binding]; other site 198628011063 hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107 198628011064 Uncharacterized signal transduction histidine kinase domain (DUF2222); Region: DUF2222; pfam09984 198628011065 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 198628011066 dimerization interface [polypeptide binding]; other site 198628011067 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 198628011068 dimer interface [polypeptide binding]; other site 198628011069 phosphorylation site [posttranslational modification] 198628011070 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 198628011071 ATP binding site [chemical binding]; other site 198628011072 Mg2+ binding site [ion binding]; other site 198628011073 G-X-G motif; other site 198628011074 Uncharacterized domain of BarA-like signal transduction histidine kinases [Signal transduction mechanisms]; Region: COG4999 198628011075 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 198628011076 active site 198628011077 phosphorylation site [posttranslational modification] 198628011078 intermolecular recognition site; other site 198628011079 dimerization interface [polypeptide binding]; other site 198628011080 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 198628011081 putative binding surface; other site 198628011082 active site 198628011083 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 198628011084 tartronate semialdehyde reductase; Provisional; Region: garR; PRK11559 198628011085 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 198628011086 alpha-dehydro-beta-deoxy-D-glucarate aldolase; Provisional; Region: PRK10558 198628011087 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 198628011088 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 198628011089 active site 198628011090 tetramer interface [polypeptide binding]; other site 198628011091 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 198628011092 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 198628011093 active site 198628011094 tetramer interface [polypeptide binding]; other site 198628011095 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198628011096 D-galactonate transporter; Region: 2A0114; TIGR00893 198628011097 putative substrate translocation pore; other site 198628011098 galactarate dehydratase; Region: galactar-dH20; TIGR03248 198628011099 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 198628011100 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 198628011101 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 198628011102 PAS domain; Region: PAS_9; pfam13426 198628011103 putative active site [active] 198628011104 heme pocket [chemical binding]; other site 198628011105 HAMP domain; Region: HAMP; pfam00672 198628011106 dimerization interface [polypeptide binding]; other site 198628011107 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 198628011108 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 198628011109 dimer interface [polypeptide binding]; other site 198628011110 putative CheW interface [polypeptide binding]; other site 198628011111 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3530 198628011112 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 198628011113 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 198628011114 nucleotide binding pocket [chemical binding]; other site 198628011115 K-X-D-G motif; other site 198628011116 catalytic site [active] 198628011117 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 198628011118 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 198628011119 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 198628011120 Dimer interface [polypeptide binding]; other site 198628011121 bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316 198628011122 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 198628011123 putative ribose interaction site [chemical binding]; other site 198628011124 putative ADP binding site [chemical binding]; other site 198628011125 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 198628011126 active site 198628011127 nucleotide binding site [chemical binding]; other site 198628011128 HIGH motif; other site 198628011129 KMSKS motif; other site 198628011130 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 198628011131 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 198628011132 metal binding triad; other site 198628011133 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 198628011134 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 198628011135 metal binding triad; other site 198628011136 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 198628011137 Uncharacterized conserved protein [Function unknown]; Region: COG3025 198628011138 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 198628011139 putative active site [active] 198628011140 putative metal binding residues [ion binding]; other site 198628011141 signature motif; other site 198628011142 putative triphosphate binding site [ion binding]; other site 198628011143 SH3 domain-containing protein; Provisional; Region: PRK10884 198628011144 Bacterial SH3 domain homologues; Region: SH3b; smart00287 198628011145 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 198628011146 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 198628011147 active site 198628011148 NTP binding site [chemical binding]; other site 198628011149 metal binding triad [ion binding]; metal-binding site 198628011150 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 198628011151 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 198628011152 Zn2+ binding site [ion binding]; other site 198628011153 Mg2+ binding site [ion binding]; other site 198628011154 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 198628011155 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 198628011156 homooctamer interface [polypeptide binding]; other site 198628011157 active site 198628011158 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 198628011159 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 198628011160 dimerization interface [polypeptide binding]; other site 198628011161 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 198628011162 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 198628011163 dimer interface [polypeptide binding]; other site 198628011164 putative CheW interface [polypeptide binding]; other site 198628011165 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 198628011166 dimer interface [polypeptide binding]; other site 198628011167 substrate binding site [chemical binding]; other site 198628011168 metal binding sites [ion binding]; metal-binding site 198628011169 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 198628011170 putative active site pocket [active] 198628011171 dimerization interface [polypeptide binding]; other site 198628011172 putative catalytic residue [active] 198628011173 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 198628011174 Family of unknown function (DUF490); Region: DUF490; pfam04357 198628011175 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 198628011176 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 198628011177 Surface antigen; Region: Bac_surface_Ag; pfam01103 198628011178 methionine sulfoxide reductase A; Provisional; Region: PRK00058 198628011179 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 198628011180 Domain of unknown function DUF21; Region: DUF21; pfam01595 198628011181 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 198628011182 Transporter associated domain; Region: CorC_HlyC; smart01091 198628011183 Protein of unknown function (DUF1107); Region: DUF1107; pfam06526 198628011184 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 198628011185 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 198628011186 active site 198628011187 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420 198628011188 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 198628011189 active site 198628011190 metal binding site [ion binding]; metal-binding site 198628011191 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 198628011192 iron-sulfur cluster repair di-iron protein; Provisional; Region: PRK10992 198628011193 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 198628011194 Hemerythrin-like domain; Region: Hr-like; cd12108 198628011195 Fe binding site [ion binding]; other site 198628011196 peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK11570 198628011197 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 198628011198 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 198628011199 Cell envelope opacity-associated protein A [Cell envelope biogenesis, outer membrane]; Region: OapA; COG3061 198628011200 Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225 198628011201 Protein of unknown function, DUF488; Region: DUF488; cl01246 198628011202 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 198628011203 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 198628011204 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 198628011205 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 198628011206 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 198628011207 dimer interface [polypeptide binding]; other site 198628011208 ssDNA binding site [nucleotide binding]; other site 198628011209 tetramer (dimer of dimers) interface [polypeptide binding]; other site 198628011210 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 198628011211 esterase; Provisional; Region: PRK10566 198628011212 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 198628011213 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 198628011214 dimerization interface [polypeptide binding]; other site 198628011215 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 198628011216 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 198628011217 dimer interface [polypeptide binding]; other site 198628011218 putative CheW interface [polypeptide binding]; other site 198628011219 putative biofilm stress and motility protein A; Provisional; Region: PRK14864 198628011220 chalcone synthase; Provisional; Region: PLN03170 198628011221 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 198628011222 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 198628011223 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 198628011224 exoribonuclease R; Provisional; Region: PRK11642 198628011225 Ribonuclease R winged-helix domain; Region: HTH_12; pfam08461 198628011226 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 198628011227 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 198628011228 RNB domain; Region: RNB; pfam00773 198628011229 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 198628011230 RNA binding site [nucleotide binding]; other site 198628011231 transcriptional repressor NsrR; Provisional; Region: PRK11014 198628011232 Rrf2 family protein; Region: rrf2_super; TIGR00738 198628011233 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 198628011234 dimer interface [polypeptide binding]; other site 198628011235 ligand binding site [chemical binding]; other site 198628011236 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 198628011237 dimerization interface [polypeptide binding]; other site 198628011238 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 198628011239 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 198628011240 dimer interface [polypeptide binding]; other site 198628011241 putative CheW interface [polypeptide binding]; other site 198628011242 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 198628011243 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 198628011244 cytosine deaminase; Provisional; Region: PRK09230 198628011245 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 198628011246 active site 198628011247 Fic/DOC family; Region: Fic; pfam02661 198628011248 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 198628011249 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 198628011250 Walker A motif; other site 198628011251 ATP binding site [chemical binding]; other site 198628011252 Walker B motif; other site 198628011253 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 198628011254 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 198628011255 catalytic residue [active] 198628011256 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 198628011257 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 198628011258 YGGT family; Region: YGGT; pfam02325 198628011259 YGGT family; Region: YGGT; pfam02325 198628011260 hypothetical protein; Validated; Region: PRK05090 198628011261 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 198628011262 active site 198628011263 dimerization interface [polypeptide binding]; other site 198628011264 HemN family oxidoreductase; Provisional; Region: PRK05660 198628011265 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 198628011266 FeS/SAM binding site; other site 198628011267 HemN C-terminal domain; Region: HemN_C; pfam06969 198628011268 entericidin A; Provisional; Region: PRK09810 198628011269 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 198628011270 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 198628011271 Coenzyme A binding pocket [chemical binding]; other site 198628011272 lysophospholipid transporter LplT; Provisional; Region: PRK11195 198628011273 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198628011274 putative substrate translocation pore; other site 198628011275 bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase; Validated; Region: PRK08043 198628011276 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 198628011277 putative acyl-acceptor binding pocket; other site 198628011278 C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Region: AAS_C; cd05909 198628011279 acyl-activating enzyme (AAE) consensus motif; other site 198628011280 putative AMP binding site [chemical binding]; other site 198628011281 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 198628011282 beta-galactosidase; Region: BGL; TIGR03356 198628011283 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 198628011284 beta-galactosidase; Region: BGL; TIGR03356 198628011285 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 198628011286 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 198628011287 active site turn [active] 198628011288 phosphorylation site [posttranslational modification] 198628011289 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 198628011290 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 198628011291 HPr interaction site; other site 198628011292 glycerol kinase (GK) interaction site [polypeptide binding]; other site 198628011293 active site 198628011294 phosphorylation site [posttranslational modification] 198628011295 transcriptional antiterminator BglG; Provisional; Region: PRK09772 198628011296 CAT RNA binding domain; Region: CAT_RBD; smart01061 198628011297 PRD domain; Region: PRD; pfam00874 198628011298 PRD domain; Region: PRD; pfam00874 198628011299 Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases [Posttranslational modification, protein turnover, chaperones]; Region: COG3555 198628011300 DNA-binding transcriptional regulator GalR; Provisional; Region: PRK10727 198628011301 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 198628011302 DNA binding site [nucleotide binding] 198628011303 domain linker motif; other site 198628011304 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 198628011305 dimerization interface (closed form) [polypeptide binding]; other site 198628011306 ligand binding site [chemical binding]; other site 198628011307 mobile mystery protein B; Region: mob_myst_B; TIGR02613 198628011308 Fic/DOC family; Region: Fic; pfam02661 198628011309 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 198628011310 Coenzyme A binding pocket [chemical binding]; other site 198628011311 DNA-binding transcriptional repressor UxuR; Provisional; Region: PRK10225 198628011312 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 198628011313 DNA-binding site [nucleotide binding]; DNA binding site 198628011314 FCD domain; Region: FCD; pfam07729 198628011315 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 198628011316 active site 198628011317 P-loop; other site 198628011318 phosphorylation site [posttranslational modification] 198628011319 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 198628011320 beta-galactosidase; Region: BGL; TIGR03356 198628011321 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 198628011322 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 198628011323 methionine cluster; other site 198628011324 PTS system, Lactose/Cellobiose specific IIA subunit; Region: PTS_IIA; pfam02255 198628011325 active site 198628011326 phosphorylation site [posttranslational modification] 198628011327 metal binding site [ion binding]; metal-binding site 198628011328 Transcriptional regulators [Transcription]; Region: PurR; COG1609 198628011329 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 198628011330 DNA binding site [nucleotide binding] 198628011331 domain linker motif; other site 198628011332 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 198628011333 dimerization interface (closed form) [polypeptide binding]; other site 198628011334 ligand binding site [chemical binding]; other site 198628011335 diaminopimelate decarboxylase; Provisional; Region: PRK11165 198628011336 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 198628011337 active site 198628011338 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 198628011339 substrate binding site [chemical binding]; other site 198628011340 catalytic residues [active] 198628011341 dimer interface [polypeptide binding]; other site 198628011342 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 198628011343 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 198628011344 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 198628011345 dimerization interface [polypeptide binding]; other site 198628011346 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 198628011347 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 198628011348 Walker A/P-loop; other site 198628011349 ATP binding site [chemical binding]; other site 198628011350 Q-loop/lid; other site 198628011351 ABC transporter signature motif; other site 198628011352 Walker B; other site 198628011353 D-loop; other site 198628011354 H-loop/switch region; other site 198628011355 TOBE domain; Region: TOBE_2; pfam08402 198628011356 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 198628011357 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198628011358 dimer interface [polypeptide binding]; other site 198628011359 conserved gate region; other site 198628011360 putative PBP binding loops; other site 198628011361 ABC-ATPase subunit interface; other site 198628011362 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198628011363 dimer interface [polypeptide binding]; other site 198628011364 conserved gate region; other site 198628011365 putative PBP binding loops; other site 198628011366 ABC-ATPase subunit interface; other site 198628011367 Uncharacterized proteins of the AP superfamily [General function prediction only]; Region: COG1524 198628011368 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 198628011369 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 198628011370 transcriptional regulator protein; Region: phnR; TIGR03337 198628011371 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 198628011372 DNA-binding site [nucleotide binding]; DNA binding site 198628011373 UTRA domain; Region: UTRA; pfam07702 198628011374 RES domain; Region: RES; cl02411 198628011375 Protein of unknown function (DUF2384); Region: DUF2384; cl17718 198628011376 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 198628011377 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 198628011378 binding surface 198628011379 TPR motif; other site 198628011380 Tetratricopeptide repeat; Region: TPR_12; pfam13424 198628011381 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 198628011382 binding surface 198628011383 TPR motif; other site 198628011384 Tetratricopeptide repeat; Region: TPR_12; pfam13424 198628011385 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 198628011386 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 198628011387 FMN binding site [chemical binding]; other site 198628011388 active site 198628011389 catalytic residues [active] 198628011390 substrate binding site [chemical binding]; other site 198628011391 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 198628011392 Cytochrome P450; Region: p450; cl12078 198628011393 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 198628011394 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 198628011395 NADP binding site [chemical binding]; other site 198628011396 dimer interface [polypeptide binding]; other site 198628011397 replicative DNA helicase; Provisional; Region: PRK08006 198628011398 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 198628011399 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 198628011400 Walker A motif; other site 198628011401 ATP binding site [chemical binding]; other site 198628011402 Walker B motif; other site 198628011403 DNA binding loops [nucleotide binding] 198628011404 alanine racemase; Reviewed; Region: alr; PRK00053 198628011405 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 198628011406 active site 198628011407 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 198628011408 substrate binding site [chemical binding]; other site 198628011409 catalytic residues [active] 198628011410 dimer interface [polypeptide binding]; other site 198628011411 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 198628011412 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 198628011413 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 198628011414 substrate binding pocket [chemical binding]; other site 198628011415 membrane-bound complex binding site; other site 198628011416 hinge residues; other site 198628011417 aromatic amino acid transporter; Provisional; Region: PRK10238 198628011418 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 198628011419 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 198628011420 putative DNA binding site [nucleotide binding]; other site 198628011421 putative Zn2+ binding site [ion binding]; other site 198628011422 AsnC family; Region: AsnC_trans_reg; pfam01037 198628011423 Uncharacterized conserved protein [Function unknown]; Region: COG1284 198628011424 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 198628011425 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 198628011426 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 198628011427 pyridoxal 5'-phosphate binding site [chemical binding]; other site 198628011428 homodimer interface [polypeptide binding]; other site 198628011429 catalytic residue [active] 198628011430 CRISPR/Cas system-associated RAMP superfamily protein Cas6f; Region: Cas6_I-F; cd09739 198628011431 CRISPR/Cas system-associated RAMP superfamily protein Csy3; Region: Csy3_I-F; cd09737 198628011432 CRISPR/Cas system-associated RAMP superfamily protein Csy2; Region: Csy2_I-F; cd09736 198628011433 CRISPR/Cas system-associated protein Csy1; Region: Csy1_I-F; cd09735 198628011434 CRISPR/Cas system-associated protein Cas3/Cas2; Region: Cas3_Cas2_I-F; cd09673 198628011435 CRISPR-associated helicase Cas3, subtype I-F/YPEST; Region: cas3_yersinia; TIGR02562 198628011436 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-F; cd09718 198628011437 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 198628011438 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 198628011439 dimerization interface [polypeptide binding]; other site 198628011440 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 198628011441 dimer interface [polypeptide binding]; other site 198628011442 putative CheW interface [polypeptide binding]; other site 198628011443 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 198628011444 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 198628011445 metal binding site [ion binding]; metal-binding site 198628011446 active site 198628011447 I-site; other site 198628011448 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 198628011449 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 198628011450 metal binding site [ion binding]; metal-binding site 198628011451 active site 198628011452 I-site; other site 198628011453 Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894 198628011454 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 198628011455 Transposase; Region: DEDD_Tnp_IS110; pfam01548 198628011456 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 198628011457 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 198628011458 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 198628011459 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 198628011460 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 198628011461 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 198628011462 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 198628011463 dimer interface [polypeptide binding]; other site 198628011464 ssDNA binding site [nucleotide binding]; other site 198628011465 tetramer (dimer of dimers) interface [polypeptide binding]; other site 198628011466 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 198628011467 Protein of unknown function (DUF4255); Region: DUF4255; pfam14065 198628011468 Phage tail sheath protein FI [General function prediction only]; Region: COG3497 198628011469 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841 198628011470 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841 198628011471 Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652 198628011472 Phage protein D [General function prediction only]; Region: COG3500 198628011473 Rhs element Vgr protein; Region: vgr_GE; TIGR01646 198628011474 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 198628011475 Uncharacterized conserved protein [Function unknown]; Region: COG4104 198628011476 Gene 25-like lysozyme; Region: GPW_gp25; pfam04965 198628011477 conserved hypothetical protein, phage tail-like region; Region: TIGR02243 198628011478 conserved hypothetical protein, phage tail-like region; Region: TIGR02243 198628011479 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 198628011480 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 198628011481 AAA domain; Region: AAA_23; pfam13476 198628011482 AAA domain; Region: AAA_21; pfam13304 198628011483 Walker A/P-loop; other site 198628011484 ATP binding site [chemical binding]; other site 198628011485 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 198628011486 ABC transporter signature motif; other site 198628011487 Walker B; other site 198628011488 D-loop; other site 198628011489 H-loop/switch region; other site 198628011490 Domain of unknown function (DUF4276); Region: DUF4276; pfam14103 198628011491 Transcriptional regulators [Transcription]; Region: PurR; COG1609 198628011492 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 198628011493 DNA binding site [nucleotide binding] 198628011494 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 198628011495 ligand binding site [chemical binding]; other site 198628011496 dimerization interface [polypeptide binding]; other site 198628011497 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 198628011498 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198628011499 dimer interface [polypeptide binding]; other site 198628011500 conserved gate region; other site 198628011501 putative PBP binding loops; other site 198628011502 ABC-ATPase subunit interface; other site 198628011503 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 198628011504 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198628011505 ABC-ATPase subunit interface; other site 198628011506 putative PBP binding loops; other site 198628011507 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 198628011508 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 198628011509 Walker A/P-loop; other site 198628011510 ATP binding site [chemical binding]; other site 198628011511 Q-loop/lid; other site 198628011512 ABC transporter signature motif; other site 198628011513 Walker B; other site 198628011514 D-loop; other site 198628011515 H-loop/switch region; other site 198628011516 TOBE domain; Region: TOBE_2; pfam08402 198628011517 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 198628011518 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 198628011519 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 198628011520 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 198628011521 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 198628011522 nucleotide binding site [chemical binding]; other site 198628011523 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198628011524 dimer interface [polypeptide binding]; other site 198628011525 conserved gate region; other site 198628011526 putative PBP binding loops; other site 198628011527 ABC-ATPase subunit interface; other site 198628011528 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 198628011529 tungstate ABC transporter binding protein WtpA; Region: tungstate_WtpA; TIGR03730 198628011530 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 198628011531 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 198628011532 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 198628011533 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 198628011534 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 198628011535 ABC-ATPase subunit interface; other site 198628011536 dimer interface [polypeptide binding]; other site 198628011537 putative PBP binding regions; other site 198628011538 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 198628011539 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 198628011540 metal binding site [ion binding]; metal-binding site 198628011541 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 198628011542 H+ Antiporter protein; Region: 2A0121; TIGR00900 198628011543 ATP-grasp domain; Region: ATP-grasp_4; cl17255 198628011544 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 198628011545 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 198628011546 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 198628011547 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 198628011548 pyridoxal 5'-phosphate binding site [chemical binding]; other site 198628011549 catalytic residue [active] 198628011550 dimer interface [polypeptide binding]; other site 198628011551 transposase remnant 198628011552 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 198628011553 active site 198628011554 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 198628011555 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 198628011556 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 198628011557 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 198628011558 4-hydroxythreonine-4-phosphate dehydrogenase 2; Provisional; Region: pdxA; PRK03371 198628011559 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 198628011560 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 198628011561 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 198628011562 5-hydroxyvalerate dehydrogenase (HVD) catalyzes the oxidation of 5-hydroxyvalerate to 5-oxovalerate with NAD+ as cofactor; Region: HVD; cd08193 198628011563 putative active site [active] 198628011564 metal binding site [ion binding]; metal-binding site 198628011565 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 198628011566 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 198628011567 inhibitor site; inhibition site 198628011568 active site 198628011569 dimer interface [polypeptide binding]; other site 198628011570 catalytic residue [active] 198628011571 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 198628011572 Na binding site [ion binding]; other site 198628011573 Predicted neuraminidase (sialidase) [Carbohydrate transport and metabolism]; Region: COG4692 198628011574 BNR repeat-like domain; Region: BNR_2; pfam13088 198628011575 Domain of unknown function (DUF386); Region: DUF386; cl01047 198628011576 short chain dehydrogenase; Provisional; Region: PRK07577 198628011577 classical (c) SDRs; Region: SDR_c; cd05233 198628011578 NAD(P) binding site [chemical binding]; other site 198628011579 active site 198628011580 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 198628011581 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 198628011582 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 198628011583 dimer interface [polypeptide binding]; other site 198628011584 putative CheW interface [polypeptide binding]; other site 198628011585 hypothetical protein; Provisional; Region: PRK05248 198628011586 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 198628011587 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 198628011588 substrate binding site [chemical binding]; other site 198628011589 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 198628011590 substrate binding site [chemical binding]; other site 198628011591 ligand binding site [chemical binding]; other site 198628011592 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 198628011593 outer membrane receptor FepA; Provisional; Region: PRK13524 198628011594 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 198628011595 N-terminal plug; other site 198628011596 ligand-binding site [chemical binding]; other site 198628011597 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 198628011598 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 198628011599 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 198628011600 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 198628011601 Abhydrolase family; Region: Abhydrolase_7; pfam12715 198628011602 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 198628011603 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 198628011604 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 198628011605 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 198628011606 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 198628011607 pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated; Region: aceF; PRK11854 198628011608 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 198628011609 E3 interaction surface; other site 198628011610 lipoyl attachment site [posttranslational modification]; other site 198628011611 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 198628011612 E3 interaction surface; other site 198628011613 lipoyl attachment site [posttranslational modification]; other site 198628011614 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 198628011615 E3 interaction surface; other site 198628011616 lipoyl attachment site [posttranslational modification]; other site 198628011617 e3 binding domain; Region: E3_binding; pfam02817 198628011618 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 198628011619 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 198628011620 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 198628011621 dimer interface [polypeptide binding]; other site 198628011622 TPP-binding site [chemical binding]; other site 198628011623 transcriptional regulator PdhR; Reviewed; Region: pdhR; PRK09464 198628011624 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 198628011625 DNA-binding site [nucleotide binding]; DNA binding site 198628011626 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 198628011627 aromatic amino acid transporter; Provisional; Region: PRK10238 198628011628 regulatory protein AmpE; Provisional; Region: PRK10987 198628011629 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 198628011630 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 198628011631 amidase catalytic site [active] 198628011632 Zn binding residues [ion binding]; other site 198628011633 substrate binding site [chemical binding]; other site 198628011634 nucleoside-specific channel-forming protein Tsx; Provisional; Region: PRK15106 198628011635 quinolinate phosphoribosyltransferase; Validated; Region: PRK09016 198628011636 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 198628011637 dimerization interface [polypeptide binding]; other site 198628011638 active site 198628011639 putative major pilin subunit; Provisional; Region: PRK10574 198628011640 Pilin (bacterial filament); Region: Pilin; pfam00114 198628011641 hypothetical protein; Provisional; Region: PRK10436 198628011642 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 198628011643 Walker A motif; other site 198628011644 ATP binding site [chemical binding]; other site 198628011645 Walker B motif; other site 198628011646 type IV pilin biogenesis protein; Provisional; Region: PRK10573 198628011647 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 198628011648 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 198628011649 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05096 198628011650 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 198628011651 active site 198628011652 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 198628011653 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 198628011654 CoA-binding site [chemical binding]; other site 198628011655 ATP-binding [chemical binding]; other site 198628011656 hypothetical protein; Provisional; Region: PRK05287 198628011657 DNA gyrase inhibitor; Reviewed; Region: PRK00418 198628011658 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 198628011659 active site 198628011660 8-oxo-dGMP binding site [chemical binding]; other site 198628011661 nudix motif; other site 198628011662 metal binding site [ion binding]; metal-binding site 198628011663 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 198628011664 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 198628011665 SEC-C motif; Region: SEC-C; pfam02810 198628011666 SecA regulator SecM; Provisional; Region: PRK02943 198628011667 Protein of unknown function (DUF721); Region: DUF721; cl02324 198628011668 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 198628011669 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 198628011670 cell division protein FtsZ; Validated; Region: PRK09330 198628011671 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 198628011672 nucleotide binding site [chemical binding]; other site 198628011673 SulA interaction site; other site 198628011674 cell division protein FtsA; Reviewed; Region: ftsA; PRK09472 198628011675 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 198628011676 Cell division protein FtsA; Region: FtsA; pfam14450 198628011677 cell division protein FtsQ; Provisional; Region: PRK10775 198628011678 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 198628011679 Cell division protein FtsQ; Region: FtsQ; pfam03799 198628011680 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 198628011681 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 198628011682 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 198628011683 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 198628011684 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 198628011685 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 198628011686 active site 198628011687 homodimer interface [polypeptide binding]; other site 198628011688 cell division protein FtsW; Provisional; Region: PRK10774 198628011689 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03806 198628011690 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 198628011691 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 198628011692 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 198628011693 Mg++ binding site [ion binding]; other site 198628011694 putative catalytic motif [active] 198628011695 putative substrate binding site [chemical binding]; other site 198628011696 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed; Region: murF; PRK10773 198628011697 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 198628011698 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 198628011699 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 198628011700 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 198628011701 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 198628011702 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 198628011703 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 198628011704 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 198628011705 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 198628011706 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 198628011707 cell division protein FtsL; Provisional; Region: PRK10772 198628011708 MraW methylase family; Region: Methyltransf_5; pfam01795 198628011709 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 198628011710 cell division protein MraZ; Reviewed; Region: PRK00326 198628011711 MraZ protein; Region: MraZ; pfam02381 198628011712 MraZ protein; Region: MraZ; pfam02381 198628011713 Protein of unknown function (DUF1144); Region: DUF1144; pfam06610 198628011714 DNA-binding transcriptional regulator FruR; Provisional; Region: PRK11303 198628011715 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 198628011716 DNA binding site [nucleotide binding] 198628011717 domain linker motif; other site 198628011718 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 198628011719 dimerization interface [polypeptide binding]; other site 198628011720 ligand binding site [chemical binding]; other site 198628011721 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 198628011722 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 198628011723 putative valine binding site [chemical binding]; other site 198628011724 dimer interface [polypeptide binding]; other site 198628011725 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 198628011726 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK07979 198628011727 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 198628011728 PYR/PP interface [polypeptide binding]; other site 198628011729 dimer interface [polypeptide binding]; other site 198628011730 TPP binding site [chemical binding]; other site 198628011731 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 198628011732 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 198628011733 TPP-binding site [chemical binding]; other site 198628011734 dimer interface [polypeptide binding]; other site 198628011735 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 198628011736 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 198628011737 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 198628011738 acyl-activating enzyme (AAE) consensus motif; other site 198628011739 putative AMP binding site [chemical binding]; other site 198628011740 putative active site [active] 198628011741 putative CoA binding site [chemical binding]; other site 198628011742 2-isopropylmalate synthase; Validated; Region: PRK00915 198628011743 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 198628011744 active site 198628011745 catalytic residues [active] 198628011746 metal binding site [ion binding]; metal-binding site 198628011747 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 198628011748 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 198628011749 tartrate dehydrogenase; Region: TTC; TIGR02089 198628011750 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 198628011751 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 198628011752 substrate binding site [chemical binding]; other site 198628011753 ligand binding site [chemical binding]; other site 198628011754 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 198628011755 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 198628011756 substrate binding site [chemical binding]; other site 198628011757 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 198628011758 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 198628011759 FAD binding pocket [chemical binding]; other site 198628011760 FAD binding motif [chemical binding]; other site 198628011761 phosphate binding motif [ion binding]; other site 198628011762 NAD binding pocket [chemical binding]; other site 198628011763 tryptophanase/L-cysteine desulfhydrase, PLP-dependent; Provisional; Region: tnaA; PRK13238 198628011764 Tryptophanase family (Tnase). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to tryptophanase (Tnase) and tyrosine phenol-lyase (TPL). Tnase and TPL are...; Region: Tnase_like; cd00617 198628011765 substrate binding site [chemical binding]; other site 198628011766 tetramer interface [polypeptide binding]; other site 198628011767 catalytic residue [active] 198628011768 transcriptional regulator SgrR; Provisional; Region: PRK13626 198628011769 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 198628011770 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 198628011771 thiamine transporter substrate binding subunit; Provisional; Region: tbpA; PRK11205 198628011772 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 198628011773 thiamine transporter membrane protein; Reviewed; Region: thiP; PRK09433 198628011774 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198628011775 dimer interface [polypeptide binding]; other site 198628011776 conserved gate region; other site 198628011777 putative PBP binding loops; other site 198628011778 ABC-ATPase subunit interface; other site 198628011779 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198628011780 dimer interface [polypeptide binding]; other site 198628011781 conserved gate region; other site 198628011782 putative PBP binding loops; other site 198628011783 ABC-ATPase subunit interface; other site 198628011784 thiamine transporter ATP-binding subunit; Provisional; Region: thiQ; PRK10771 198628011785 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 198628011786 Walker A/P-loop; other site 198628011787 ATP binding site [chemical binding]; other site 198628011788 Q-loop/lid; other site 198628011789 ABC transporter signature motif; other site 198628011790 Walker B; other site 198628011791 D-loop; other site 198628011792 H-loop/switch region; other site 198628011793 acetolactate synthase catalytic subunit; Validated; Region: PRK08155 198628011794 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 198628011795 PYR/PP interface [polypeptide binding]; other site 198628011796 dimer interface [polypeptide binding]; other site 198628011797 TPP binding site [chemical binding]; other site 198628011798 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 198628011799 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 198628011800 TPP-binding site [chemical binding]; other site 198628011801 dimer interface [polypeptide binding]; other site 198628011802 Acetolactate synthase, small (regulatory) subunit [Amino acid transport and metabolism]; Region: IlvH; COG0440 198628011803 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 198628011804 putative valine binding site [chemical binding]; other site 198628011805 dimer interface [polypeptide binding]; other site 198628011806 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 198628011807 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 198628011808 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 198628011809 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 198628011810 Protein of unknown function (DUF3380); Region: DUF3380; pfam11860 198628011811 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 198628011812 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 198628011813 Walker A/P-loop; other site 198628011814 ATP binding site [chemical binding]; other site 198628011815 Q-loop/lid; other site 198628011816 ABC transporter signature motif; other site 198628011817 Walker B; other site 198628011818 D-loop; other site 198628011819 H-loop/switch region; other site 198628011820 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 198628011821 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 198628011822 Walker A/P-loop; other site 198628011823 ATP binding site [chemical binding]; other site 198628011824 Q-loop/lid; other site 198628011825 ABC transporter signature motif; other site 198628011826 Walker B; other site 198628011827 D-loop; other site 198628011828 H-loop/switch region; other site 198628011829 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 198628011830 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 198628011831 TM-ABC transporter signature motif; other site 198628011832 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 198628011833 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 198628011834 TM-ABC transporter signature motif; other site 198628011835 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 198628011836 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 198628011837 putative ligand binding site [chemical binding]; other site 198628011838 DNA polymerase II; Reviewed; Region: PRK05762 198628011839 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784 198628011840 active site 198628011841 catalytic site [active] 198628011842 substrate binding site [chemical binding]; other site 198628011843 DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537 198628011844 active site 198628011845 metal-binding site 198628011846 ATP-dependent helicase HepA; Validated; Region: PRK04914 198628011847 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 198628011848 ATP binding site [chemical binding]; other site 198628011849 putative Mg++ binding site [ion binding]; other site 198628011850 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 198628011851 nucleotide binding region [chemical binding]; other site 198628011852 ATP-binding site [chemical binding]; other site 198628011853 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 198628011854 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 198628011855 active site 198628011856 Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430 198628011857 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 198628011858 putative metal binding site [ion binding]; other site 198628011859 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 198628011860 HSP70 interaction site [polypeptide binding]; other site 198628011861 LPS assembly outer membrane complex protein LptD; Provisional; Region: PRK03761 198628011862 OstA-like protein; Region: OstA; cl00844 198628011863 OstA-like protein; Region: OstA; pfam03968 198628011864 Organic solvent tolerance protein; Region: OstA_C; pfam04453 198628011865 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 198628011866 SurA N-terminal domain; Region: SurA_N; pfam09312 198628011867 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 198628011868 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 198628011869 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 198628011870 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 198628011871 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 198628011872 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 198628011873 S-adenosylmethionine binding site [chemical binding]; other site 198628011874 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 198628011875 diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166 198628011876 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 198628011877 active site 198628011878 metal binding site [ion binding]; metal-binding site 198628011879 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 198628011880 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 198628011881 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 198628011882 folate binding site [chemical binding]; other site 198628011883 NADP+ binding site [chemical binding]; other site 198628011884 hypothetical protein; Provisional; Region: PRK09917 198628011885 Uncharacterized conserved protein [Function unknown]; Region: COG2966 198628011886 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 198628011887 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 198628011888 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 198628011889 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 198628011890 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 198628011891 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 198628011892 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 198628011893 ATP-grasp domain; Region: ATP-grasp_4; cl17255 198628011894 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 198628011895 IMP binding site; other site 198628011896 dimer interface [polypeptide binding]; other site 198628011897 interdomain contacts; other site 198628011898 partial ornithine binding site; other site 198628011899 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 198628011900 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 198628011901 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 198628011902 catalytic site [active] 198628011903 subunit interface [polypeptide binding]; other site 198628011904 Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289 198628011905 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 198628011906 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 198628011907 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 198628011908 active site 198628011909 tetramer interface [polypeptide binding]; other site 198628011910 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 198628011911 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 198628011912 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 198628011913 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 198628011914 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 198628011915 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 198628011916 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 198628011917 active site 198628011918 HIGH motif; other site 198628011919 nucleotide binding site [chemical binding]; other site 198628011920 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 198628011921 active site 198628011922 KMSKS motif; other site 198628011923 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 198628011924 tRNA binding surface [nucleotide binding]; other site 198628011925 anticodon binding site; other site 198628011926 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 198628011927 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 198628011928 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 198628011929 active site 198628011930 Riboflavin kinase; Region: Flavokinase; smart00904 198628011931 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 198628011932 transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062 198628011933 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 198628011934 The C-terminal substrate binding domain of LysR-type transcriptional activator of the nhaA gene, encoding Na+/H+ antiporter, contains the type 2 periplasmic binding fold; Region: PBP2_NhaR; cd08429 198628011935 putative dimerization interface [polypeptide binding]; other site 198628011936 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09561 198628011937 chaperone protein DnaJ; Provisional; Region: PRK10767 198628011938 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 198628011939 HSP70 interaction site [polypeptide binding]; other site 198628011940 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 198628011941 substrate binding site [polypeptide binding]; other site 198628011942 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 198628011943 Zn binding sites [ion binding]; other site 198628011944 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 198628011945 dimer interface [polypeptide binding]; other site 198628011946 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 198628011947 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 198628011948 nucleotide binding site [chemical binding]; other site 198628011949 hypothetical protein; Provisional; Region: PRK10659 198628011950 metabolite-proton symporter; Region: 2A0106; TIGR00883 198628011951 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198628011952 putative substrate translocation pore; other site 198628011953 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 198628011954 MPT binding site; other site 198628011955 trimer interface [polypeptide binding]; other site 198628011956 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 198628011957 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 198628011958 metal binding site [ion binding]; metal-binding site 198628011959 active site 198628011960 I-site; other site 198628011961 transaldolase-like protein; Provisional; Region: PTZ00411 198628011962 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 198628011963 active site 198628011964 dimer interface [polypeptide binding]; other site 198628011965 catalytic residue [active] 198628011966 hypothetical protein; Validated; Region: PRK02101 198628011967 threonine synthase; Validated; Region: PRK09225 198628011968 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 198628011969 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 198628011970 catalytic residue [active] 198628011971 homoserine kinase; Provisional; Region: PRK01212 198628011972 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 198628011973 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 198628011974 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 198628011975 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 198628011976 putative catalytic residues [active] 198628011977 putative nucleotide binding site [chemical binding]; other site 198628011978 putative aspartate binding site [chemical binding]; other site 198628011979 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 198628011980 dimer interface [polypeptide binding]; other site 198628011981 putative threonine allosteric regulatory site; other site 198628011982 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922 198628011983 putative threonine allosteric regulatory site; other site 198628011984 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 198628011985 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 198628011986 putative RNA methyltransferase; Provisional; Region: PRK10433 198628011987 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 198628011988 two-component response regulator; Provisional; Region: PRK11173 198628011989 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 198628011990 active site 198628011991 phosphorylation site [posttranslational modification] 198628011992 intermolecular recognition site; other site 198628011993 dimerization interface [polypeptide binding]; other site 198628011994 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 198628011995 DNA binding site [nucleotide binding] 198628011996 hypothetical protein; Provisional; Region: PRK10756 198628011997 CreA protein; Region: CreA; pfam05981 198628011998 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 198628011999 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 198628012000 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 198628012001 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 198628012002 catalytic core [active] 198628012003 inosine/xanthosine triphosphatase; Reviewed; Region: PRK05074 198628012004 Trp operon repressor; Provisional; Region: PRK01381 198628012005 lytic murein transglycosylase; Provisional; Region: PRK11619 198628012006 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 198628012007 N-acetyl-D-glucosamine binding site [chemical binding]; other site 198628012008 catalytic residue [active] 198628012009 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 198628012010 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 198628012011 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 198628012012 ABC transporter; Region: ABC_tran_2; pfam12848 198628012013 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 198628012014 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 198628012015 dimer interface [polypeptide binding]; other site 198628012016 ligand binding site [chemical binding]; other site 198628012017 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 198628012018 dimerization interface [polypeptide binding]; other site 198628012019 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 198628012020 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 198628012021 dimer interface [polypeptide binding]; other site 198628012022 putative CheW interface [polypeptide binding]; other site 198628012023 Transcriptional regulator [Transcription]; Region: LysR; COG0583 198628012024 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 198628012025 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 198628012026 putative effector binding pocket; other site 198628012027 dimerization interface [polypeptide binding]; other site 198628012028 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 198628012029 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 198628012030 putative NAD(P) binding site [chemical binding]; other site 198628012031 dimer interface [polypeptide binding]; other site 198628012032 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 198628012033 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 198628012034 ligand binding site [chemical binding]; other site 198628012035 NAD binding site [chemical binding]; other site 198628012036 tetramer interface [polypeptide binding]; other site 198628012037 catalytic site [active] 198628012038 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 198628012039 L-serine binding site [chemical binding]; other site 198628012040 ACT domain interface; other site 198628012041 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 198628012042 tetramer (dimer of dimers) interface [polypeptide binding]; other site 198628012043 active site 198628012044 dimer interface [polypeptide binding]; other site 198628012045 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 198628012046 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 198628012047 The C-terminal substrate binding domain of LysR-type transcriptional regulator, ArgP (IciA), for arginine exporter (ArgO); contains the type 2 periplasmic binding fold; Region: PBP2_IciA_ArgP; cd08428 198628012048 putative dimerization interface [polypeptide binding]; other site 198628012049 Uncharacterized conserved protein [Function unknown]; Region: COG2968 198628012050 oxidative stress defense protein; Provisional; Region: PRK11087 198628012051 Transcriptional regulator [Transcription]; Region: IclR; COG1414 198628012052 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 198628012053 Bacterial transcriptional regulator; Region: IclR; pfam01614 198628012054 mechanosensitive channel MscS; Provisional; Region: PRK10334 198628012055 Conserved TM helix; Region: TM_helix; pfam05552 198628012056 Mechanosensitive ion channel; Region: MS_channel; pfam00924 198628012057 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 198628012058 Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946 198628012059 active site 198628012060 intersubunit interface [polypeptide binding]; other site 198628012061 zinc binding site [ion binding]; other site 198628012062 Na+ binding site [ion binding]; other site 198628012063 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 198628012064 Phosphoglycerate kinase; Region: PGK; pfam00162 198628012065 substrate binding site [chemical binding]; other site 198628012066 hinge regions; other site 198628012067 ADP binding site [chemical binding]; other site 198628012068 catalytic site [active] 198628012069 erythrose 4-phosphate dehydrogenase; Provisional; Region: PRK13535 198628012070 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 198628012071 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 198628012072 transketolase; Reviewed; Region: PRK12753 198628012073 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 198628012074 TPP-binding site [chemical binding]; other site 198628012075 dimer interface [polypeptide binding]; other site 198628012076 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 198628012077 PYR/PP interface [polypeptide binding]; other site 198628012078 dimer interface [polypeptide binding]; other site 198628012079 TPP binding site [chemical binding]; other site 198628012080 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 198628012081 putative transporter; Provisional; Region: PRK03699 198628012082 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198628012083 putative substrate translocation pore; other site 198628012084 arginine decarboxylase; Provisional; Region: PRK05354 198628012085 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 198628012086 dimer interface [polypeptide binding]; other site 198628012087 active site 198628012088 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 198628012089 catalytic residues [active] 198628012090 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 198628012091 S-adenosylmethionine synthetase; Validated; Region: PRK05250 198628012092 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 198628012093 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 198628012094 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 198628012095 hypothetical protein; Provisional; Region: PRK04860 198628012096 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 198628012097 DNA-specific endonuclease I; Provisional; Region: PRK15137 198628012098 Endonuclease I [DNA replication, recombination, and repair]; Region: EndA; COG2356 198628012099 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 198628012100 RNA methyltransferase, RsmE family; Region: TIGR00046 198628012101 glutathione synthetase; Provisional; Region: PRK05246 198628012102 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 198628012103 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 198628012104 hypothetical protein; Validated; Region: PRK00228 198628012105 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 198628012106 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 198628012107 AMP binding site [chemical binding]; other site 198628012108 metal binding site [ion binding]; metal-binding site 198628012109 active site 198628012110 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 198628012111 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 198628012112 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 198628012113 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 198628012114 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 198628012115 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 198628012116 GDP-binding site [chemical binding]; other site 198628012117 ACT binding site; other site 198628012118 IMP binding site; other site 198628012119 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3242 198628012120 FtsH protease regulator HflC; Provisional; Region: PRK11029 198628012121 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 198628012122 FtsH protease regulator HflK; Provisional; Region: PRK10930 198628012123 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 198628012124 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 198628012125 GTPase HflX; Provisional; Region: PRK11058 198628012126 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 198628012127 HflX GTPase family; Region: HflX; cd01878 198628012128 G1 box; other site 198628012129 GTP/Mg2+ binding site [chemical binding]; other site 198628012130 Switch I region; other site 198628012131 G2 box; other site 198628012132 G3 box; other site 198628012133 Switch II region; other site 198628012134 G4 box; other site 198628012135 G5 box; other site 198628012136 bacterial Hfq-like; Region: Hfq; cd01716 198628012137 hexamer interface [polypeptide binding]; other site 198628012138 Sm1 motif; other site 198628012139 RNA binding site [nucleotide binding]; other site 198628012140 Sm2 motif; other site 198628012141 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 198628012142 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 198628012143 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 198628012144 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 198628012145 ATP binding site [chemical binding]; other site 198628012146 Mg2+ binding site [ion binding]; other site 198628012147 G-X-G motif; other site 198628012148 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 198628012149 ATP binding site [chemical binding]; other site 198628012150 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 198628012151 N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431 198628012152 AMIN domain; Region: AMIN; pfam11741 198628012153 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 198628012154 active site 198628012155 metal binding site [ion binding]; metal-binding site 198628012156 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 198628012157 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 198628012158 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 198628012159 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 198628012160 putative carbohydrate kinase; Provisional; Region: PRK10565 198628012161 Uncharacterized conserved protein [Function unknown]; Region: COG0062 198628012162 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 198628012163 putative substrate binding site [chemical binding]; other site 198628012164 putative ATP binding site [chemical binding]; other site 198628012165 epoxyqueuosine reductase; Region: TIGR00276 198628012166 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 198628012167 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 198628012168 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 198628012169 Substrate binding site; other site 198628012170 Cupin domain; Region: Cupin_2; cl17218 198628012171 phosphomannomutase CpsG; Provisional; Region: PRK15414 198628012172 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 198628012173 active site 198628012174 substrate binding site [chemical binding]; other site 198628012175 metal binding site [ion binding]; metal-binding site 198628012176 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 198628012177 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 198628012178 NADP-binding site; other site 198628012179 homotetramer interface [polypeptide binding]; other site 198628012180 substrate binding site [chemical binding]; other site 198628012181 homodimer interface [polypeptide binding]; other site 198628012182 active site 198628012183 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 198628012184 ABC-2 type transporter; Region: ABC2_membrane; cl17235 198628012185 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 198628012186 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 198628012187 Walker A/P-loop; other site 198628012188 ATP binding site [chemical binding]; other site 198628012189 Q-loop/lid; other site 198628012190 ABC transporter signature motif; other site 198628012191 Walker B; other site 198628012192 D-loop; other site 198628012193 H-loop/switch region; other site 198628012194 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 198628012195 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 198628012196 NADP binding site [chemical binding]; other site 198628012197 active site 198628012198 putative substrate binding site [chemical binding]; other site 198628012199 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 198628012200 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 198628012201 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_4; cd03795 198628012202 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 198628012203 putative ADP-binding pocket [chemical binding]; other site 198628012204 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 198628012205 Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300 198628012206 NAD binding site [chemical binding]; other site 198628012207 ligand binding site [chemical binding]; other site 198628012208 catalytic site [active] 198628012209 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 198628012210 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 198628012211 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 198628012212 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 198628012213 active site 198628012214 non-prolyl cis peptide bond; other site 198628012215 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 198628012216 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 198628012217 substrate binding pocket [chemical binding]; other site 198628012218 membrane-bound complex binding site; other site 198628012219 hinge residues; other site 198628012220 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 198628012221 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 198628012222 substrate binding pocket [chemical binding]; other site 198628012223 membrane-bound complex binding site; other site 198628012224 hinge residues; other site 198628012225 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 198628012226 Coenzyme A binding pocket [chemical binding]; other site 198628012227 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198628012228 dimer interface [polypeptide binding]; other site 198628012229 conserved gate region; other site 198628012230 putative PBP binding loops; other site 198628012231 ABC-ATPase subunit interface; other site 198628012232 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 198628012233 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 198628012234 Walker A/P-loop; other site 198628012235 ATP binding site [chemical binding]; other site 198628012236 Q-loop/lid; other site 198628012237 ABC transporter signature motif; other site 198628012238 Walker B; other site 198628012239 D-loop; other site 198628012240 H-loop/switch region; other site 198628012241 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 198628012242 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 198628012243 Transcriptional regulators [Transcription]; Region: MarR; COG1846 198628012244 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 198628012245 putative Zn2+ binding site [ion binding]; other site 198628012246 putative DNA binding site [nucleotide binding]; other site 198628012247 putative aminobenzoyl-glutamate transporter; Provisional; Region: abgT; PRK11339 198628012248 p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819 198628012249 M20 Peptidase Aminoacylase 1-like protein 2 aminobenzoyl-glutamate utilization protein B subfamily; Region: M20_Acy1L2_AbgB; cd05673 198628012250 amidohydrolase; Region: amidohydrolases; TIGR01891 198628012251 putative metal binding site [ion binding]; other site 198628012252 M20 Peptidases Aminoacyclase-1 indole-3-acetic-L-aspartic acid hydrolase from bacteria and archaea; Region: M20_Acy1_IAAspH_bact; cd05665 198628012253 amidohydrolase; Region: amidohydrolases; TIGR01891 198628012254 putative metal binding site [ion binding]; other site 198628012255 dimer interface [polypeptide binding]; other site 198628012256 putative DNA-binding transcriptional regulator; Provisional; Region: PRK09791 198628012257 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 198628012258 The C-terminal substrate binding domain of LysR-type transcriptional regulator TdcA, which is involved in the degradation of L-serine and L-threonine, contains the type 2 periplasmic binding fold; Region: PBP2_TdcA; cd08418 198628012259 putative substrate binding pocket [chemical binding]; other site 198628012260 putative dimerization interface [polypeptide binding]; other site 198628012261 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 198628012262 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 198628012263 dimerization interface [polypeptide binding]; other site 198628012264 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 198628012265 dimer interface [polypeptide binding]; other site 198628012266 putative CheW interface [polypeptide binding]; other site 198628012267 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 198628012268 Transposase; Region: DEDD_Tnp_IS110; pfam01548 198628012269 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 198628012270 NifQ; Region: NifQ; pfam04891 198628012271 nitrogenase cofactor biosynthesis protein NifB; Region: nifB; TIGR01290 198628012272 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 198628012273 FeS/SAM binding site; other site 198628012274 NifB belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme as part of...; Region: NifB; cd00852 198628012275 Nif-specific regulatory protein; Region: nifA; TIGR01817 198628012276 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 198628012277 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 198628012278 Walker A motif; other site 198628012279 ATP binding site [chemical binding]; other site 198628012280 Walker B motif; other site 198628012281 arginine finger; other site 198628012282 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 198628012283 nitrogen fixation negative regulator NifL; Region: nifL_nitrog; TIGR02938 198628012284 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 198628012285 putative active site [active] 198628012286 heme pocket [chemical binding]; other site 198628012287 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 198628012288 ATP binding site [chemical binding]; other site 198628012289 Mg2+ binding site [ion binding]; other site 198628012290 G-X-G motif; other site 198628012291 flavodoxin FldA; Validated; Region: PRK09267 198628012292 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 198628012293 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 198628012294 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 198628012295 AlkA N-terminal domain; Region: AlkA_N; pfam06029 198628012296 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 198628012297 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 198628012298 minor groove reading motif; other site 198628012299 helix-hairpin-helix signature motif; other site 198628012300 substrate binding pocket [chemical binding]; other site 198628012301 active site 198628012302 nitrogen fixation protein NifM; Region: nifM_nitrog; TIGR02933 198628012303 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 198628012304 NifZ domain; Region: NifZ; pfam04319 198628012305 Nitrogen fixation protein NifW; Region: NifW; cl03935 198628012306 homocitrate synthase NifV; Region: nifV_homocitr; TIGR02660 198628012307 Streptomyces rubellomurinus FrbC and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_NifV; cd07939 198628012308 active site 198628012309 catalytic residues [active] 198628012310 metal binding site [ion binding]; metal-binding site 198628012311 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 198628012312 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 198628012313 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 198628012314 catalytic residue [active] 198628012315 Fe-S cluster assembly protein NifU; Region: NifU_proper; TIGR02000 198628012316 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 198628012317 trimerization site [polypeptide binding]; other site 198628012318 active site 198628012319 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 198628012320 NifU-like domain; Region: NifU; pfam01106 198628012321 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 198628012322 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 198628012323 catalytic residue [active] 198628012324 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 198628012325 NifX belongs to a family of iron-molybdenum cluster-binding proteins that includes NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. The protein...; Region: NifX; cd00853 198628012326 Nitrogenase_nifN1: A subgroup of the NifN subunit of the NifEN complex: NifN forms an alpha2beta2 tetramer with NifE. NifN and nifE are structurally homologous to nitrogenase MoFe protein beta and alpha subunits respectively. NifEN participates in the...; Region: Nitrogenase_NifN_1; cd01966 198628012327 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 198628012328 nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283 198628012329 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 198628012330 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 198628012331 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 198628012332 dimer interface [polypeptide binding]; other site 198628012333 ligand binding site [chemical binding]; other site 198628012334 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 198628012335 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 198628012336 dimer interface [polypeptide binding]; other site 198628012337 putative CheW interface [polypeptide binding]; other site 198628012338 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 198628012339 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 198628012340 non-specific DNA binding site [nucleotide binding]; other site 198628012341 salt bridge; other site 198628012342 sequence-specific DNA binding site [nucleotide binding]; other site 198628012343 This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. This...; Region: NifX_NifB; cl00252 198628012344 NifT/FixU protein; Region: NifT; pfam06988 198628012345 nitrogenase molybdenum-iron protein beta chain; Region: nifK; TIGR01286 198628012346 Domain of unknown function (DUF3364); Region: DUF3364; pfam11844 198628012347 Nitrogenase_MoFe_beta: Nitrogenase MoFe protein, beta subunit. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to ammonia. The Molybdenum (Mo-) nitrogenase is the most widespread and best characterized of these systems; Region: Nitrogenase_MoFe_beta; cd01974 198628012348 MoFe protein beta/alpha subunit interactions; other site 198628012349 Beta subunit P cluster binding residues; other site 198628012350 MoFe protein beta subunit/Fe protein contacts; other site 198628012351 MoFe protein dimer/ dimer interactions; other site 198628012352 Nitrogenase molybdenum-iron protein, alpha and beta chains [Energy production and conversion]; Region: NifD; COG2710 198628012353 Nitrogenase_MoFe_alpha_II: Nitrogenase MoFe protein, beta subunit. A group of proteins similar to the alpha subunit of the MoFe protein of the molybdenum (Mo-) nitrogenase. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to...; Region: Nitrogenase_MoFe_alpha; cd01976 198628012354 MoFe protein alpha/beta subunit interactions; other site 198628012355 Alpha subunit P cluster binding residues; other site 198628012356 FeMoco binding residues [chemical binding]; other site 198628012357 MoFe protein alpha subunit/Fe protein contacts; other site 198628012358 MoFe protein dimer/ dimer interactions; other site 198628012359 NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040 198628012360 nitrogenase iron protein; Region: nifH; TIGR01287 198628012361 Nucleotide-binding sites [chemical binding]; other site 198628012362 Walker A motif; other site 198628012363 Switch I region of nucleotide binding site; other site 198628012364 Fe4S4 binding sites [ion binding]; other site 198628012365 Switch II region of nucleotide binding site; other site 198628012366 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 198628012367 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 198628012368 dimer interface [polypeptide binding]; other site 198628012369 PYR/PP interface [polypeptide binding]; other site 198628012370 TPP binding site [chemical binding]; other site 198628012371 substrate binding site [chemical binding]; other site 198628012372 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 198628012373 Domain of unknown function; Region: EKR; smart00890 198628012374 4Fe-4S binding domain; Region: Fer4_6; pfam12837 198628012375 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 198628012376 TPP-binding site [chemical binding]; other site 198628012377 dimer interface [polypeptide binding]; other site 198628012378 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 198628012379 catalytic site [active] 198628012380 putative active site [active] 198628012381 putative substrate binding site [chemical binding]; other site 198628012382 dimer interface [polypeptide binding]; other site 198628012383 GTPase RsgA; Reviewed; Region: PRK12288 198628012384 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 198628012385 RNA binding site [nucleotide binding]; other site 198628012386 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 198628012387 GTPase/Zn-binding domain interface [polypeptide binding]; other site 198628012388 GTP/Mg2+ binding site [chemical binding]; other site 198628012389 G4 box; other site 198628012390 G5 box; other site 198628012391 G1 box; other site 198628012392 Switch I region; other site 198628012393 G2 box; other site 198628012394 G3 box; other site 198628012395 Switch II region; other site 198628012396 phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044 198628012397 putative mechanosensitive channel protein; Provisional; Region: PRK10929 198628012398 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 198628012399 Mechanosensitive ion channel; Region: MS_channel; pfam00924 198628012400 poxB regulator PoxA; Provisional; Region: PRK09350 198628012401 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 198628012402 motif 1; other site 198628012403 dimer interface [polypeptide binding]; other site 198628012404 active site 198628012405 motif 2; other site 198628012406 motif 3; other site 198628012407 fumarate reductase flavoprotein subunit; Validated; Region: PRK09231 198628012408 L-aspartate oxidase; Provisional; Region: PRK06175 198628012409 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 198628012410 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12385 198628012411 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 198628012412 Quinol:fumarate reductase (QFR) Type D subfamily, 15kD hydrophobic subunit C; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitC; cd00546 198628012413 D-subunit interface [polypeptide binding]; other site 198628012414 Iron-sulfur protein interface; other site 198628012415 proximal quinone binding site [chemical binding]; other site 198628012416 Quinol:fumarate reductase (QFR) Type D subfamily, 13kD hydrophobic subunit D; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitD; cd00547 198628012417 Iron-sulfur protein interface; other site 198628012418 proximal quinone binding site [chemical binding]; other site 198628012419 C-subunit interface; other site 198628012420 distal quinone binding site; other site 198628012421 outer membrane lipoprotein Blc; Provisional; Region: PRK10477 198628012422 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 198628012423 Protein of unknown function, DUF486; Region: DUF486; cl01236 198628012424 elongation factor P; Validated; Region: PRK00529 198628012425 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 198628012426 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 198628012427 RNA binding site [nucleotide binding]; other site 198628012428 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 198628012429 RNA binding site [nucleotide binding]; other site 198628012430 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 198628012431 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 198628012432 FeS/SAM binding site; other site 198628012433 Domain of unknown function (DUF4156); Region: DUF4156; pfam13698 198628012434 Glycosyl hydrolase family 26; Region: Glyco_hydro_26; pfam02156 198628012435 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 198628012436 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 198628012437 active site 198628012438 dimer interface [polypeptide binding]; other site 198628012439 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 198628012440 dimer interface [polypeptide binding]; other site 198628012441 active site 198628012442 aspartate kinase III; Validated; Region: PRK09084 198628012443 AAK_AKiii-LysC-EC: Amino Acid Kinase Superfamily (AAK), AKiii-LysC-EC: this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKIII. AKIII is a monofunctional class enzyme (LysC) found in some...; Region: AAK_AKiii-LysC-EC; cd04258 198628012444 nucleotide binding site [chemical binding]; other site 198628012445 putative catalytic residues [active] 198628012446 aspartate binding site [chemical binding]; other site 198628012447 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 198628012448 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_2; cd04917 198628012449 dimer interface [polypeptide binding]; other site 198628012450 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 198628012451 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 198628012452 PhoU domain; Region: PhoU; pfam01895 198628012453 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 198628012454 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 198628012455 transmembrane helices; other site 198628012456 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 198628012457 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 198628012458 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 198628012459 substrate binding pocket [chemical binding]; other site 198628012460 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 198628012461 B12 binding site [chemical binding]; other site 198628012462 cobalt ligand [ion binding]; other site 198628012463 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 198628012464 transcriptional repressor IclR; Provisional; Region: PRK11569 198628012465 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 198628012466 Bacterial transcriptional regulator; Region: IclR; pfam01614 198628012467 Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579 198628012468 bifunctional isocitrate dehydrogenase kinase/phosphatase protein; Validated; Region: aceK; PRK02946 198628012469 isocitrate lyase; Provisional; Region: PRK15063 198628012470 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 198628012471 tetramer interface [polypeptide binding]; other site 198628012472 active site 198628012473 Mg2+/Mn2+ binding site [ion binding]; other site 198628012474 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 198628012475 malate synthase A; Region: malate_syn_A; TIGR01344 198628012476 active site 198628012477 homoserine O-succinyltransferase; Provisional; Region: PRK05368 198628012478 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 198628012479 proposed active site lysine [active] 198628012480 conserved cys residue [active] 198628012481 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 198628012482 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 198628012483 trimer interface [polypeptide binding]; other site 198628012484 putative metal binding site [ion binding]; other site 198628012485 Protein of unknown function (DUF1488); Region: DUF1488; pfam07369 198628012486 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 198628012487 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 198628012488 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 198628012489 shikimate binding site; other site 198628012490 NAD(P) binding site [chemical binding]; other site 198628012491 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 198628012492 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 198628012493 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 198628012494 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 198628012495 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 198628012496 hypothetical protein; Validated; Region: PRK03430 198628012497 hypothetical protein; Provisional; Region: PRK10736 198628012498 DNA protecting protein DprA; Region: dprA; TIGR00732 198628012499 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 198628012500 active site 198628012501 catalytic residues [active] 198628012502 metal binding site [ion binding]; metal-binding site 198628012503 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 198628012504 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 198628012505 putative active site [active] 198628012506 substrate binding site [chemical binding]; other site 198628012507 putative cosubstrate binding site; other site 198628012508 catalytic site [active] 198628012509 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 198628012510 substrate binding site [chemical binding]; other site 198628012511 16S rRNA methyltransferase B; Provisional; Region: PRK10901 198628012512 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 198628012513 putative RNA binding site [nucleotide binding]; other site 198628012514 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 198628012515 S-adenosylmethionine binding site [chemical binding]; other site 198628012516 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 198628012517 TrkA-N domain; Region: TrkA_N; pfam02254 198628012518 TrkA-C domain; Region: TrkA_C; pfam02080 198628012519 TrkA-N domain; Region: TrkA_N; pfam02254 198628012520 TrkA-C domain; Region: TrkA_C; pfam02080 198628012521 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 198628012522 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 198628012523 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3036 198628012524 hypothetical protein; Provisional; Region: PRK10203 198628012525 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 198628012526 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 198628012527 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 198628012528 alphaNTD homodimer interface [polypeptide binding]; other site 198628012529 alphaNTD - beta interaction site [polypeptide binding]; other site 198628012530 alphaNTD - beta' interaction site [polypeptide binding]; other site 198628012531 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 198628012532 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 198628012533 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 198628012534 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 198628012535 RNA binding surface [nucleotide binding]; other site 198628012536 30S ribosomal protein S11; Validated; Region: PRK05309 198628012537 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 198628012538 30S ribosomal protein S13; Region: bact_S13; TIGR03631 198628012539 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 198628012540 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 198628012541 SecY translocase; Region: SecY; pfam00344 198628012542 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 198628012543 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 198628012544 23S rRNA binding site [nucleotide binding]; other site 198628012545 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 198628012546 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 198628012547 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 198628012548 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 198628012549 5S rRNA interface [nucleotide binding]; other site 198628012550 23S rRNA interface [nucleotide binding]; other site 198628012551 L5 interface [polypeptide binding]; other site 198628012552 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 198628012553 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 198628012554 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 198628012555 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 198628012556 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 198628012557 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 198628012558 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 198628012559 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 198628012560 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 198628012561 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 198628012562 RNA binding site [nucleotide binding]; other site 198628012563 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 198628012564 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 198628012565 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 198628012566 23S rRNA interface [nucleotide binding]; other site 198628012567 putative translocon interaction site; other site 198628012568 signal recognition particle (SRP54) interaction site; other site 198628012569 L23 interface [polypeptide binding]; other site 198628012570 trigger factor interaction site; other site 198628012571 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 198628012572 23S rRNA interface [nucleotide binding]; other site 198628012573 5S rRNA interface [nucleotide binding]; other site 198628012574 putative antibiotic binding site [chemical binding]; other site 198628012575 L25 interface [polypeptide binding]; other site 198628012576 L27 interface [polypeptide binding]; other site 198628012577 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 198628012578 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 198628012579 G-X-X-G motif; other site 198628012580 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 198628012581 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 198628012582 protein-rRNA interface [nucleotide binding]; other site 198628012583 putative translocon binding site; other site 198628012584 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 198628012585 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 198628012586 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 198628012587 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 198628012588 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 198628012589 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 198628012590 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 198628012591 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 198628012592 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 198628012593 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 198628012594 heme binding site [chemical binding]; other site 198628012595 ferroxidase pore; other site 198628012596 ferroxidase diiron center [ion binding]; other site 198628012597 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 198628012598 elongation factor Tu; Reviewed; Region: PRK00049 198628012599 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 198628012600 G1 box; other site 198628012601 GEF interaction site [polypeptide binding]; other site 198628012602 GTP/Mg2+ binding site [chemical binding]; other site 198628012603 Switch I region; other site 198628012604 G2 box; other site 198628012605 G3 box; other site 198628012606 Switch II region; other site 198628012607 G4 box; other site 198628012608 G5 box; other site 198628012609 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 198628012610 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 198628012611 Antibiotic Binding Site [chemical binding]; other site 198628012612 elongation factor G; Reviewed; Region: PRK00007 198628012613 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 198628012614 G1 box; other site 198628012615 putative GEF interaction site [polypeptide binding]; other site 198628012616 GTP/Mg2+ binding site [chemical binding]; other site 198628012617 Switch I region; other site 198628012618 G2 box; other site 198628012619 G3 box; other site 198628012620 Switch II region; other site 198628012621 G4 box; other site 198628012622 G5 box; other site 198628012623 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 198628012624 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 198628012625 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 198628012626 30S ribosomal protein S7; Validated; Region: PRK05302 198628012627 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 198628012628 S17 interaction site [polypeptide binding]; other site 198628012629 S8 interaction site; other site 198628012630 16S rRNA interaction site [nucleotide binding]; other site 198628012631 streptomycin interaction site [chemical binding]; other site 198628012632 23S rRNA interaction site [nucleotide binding]; other site 198628012633 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 198628012634 sulfur transfer complex subunit TusB; Provisional; Region: PRK13510 198628012635 sulfur relay protein TusC; Validated; Region: PRK00211 198628012636 sulfur transfer complex subunit TusD; Validated; Region: PRK00207 198628012637 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 198628012638 YheO-like PAS domain; Region: PAS_6; pfam08348 198628012639 HTH domain; Region: HTH_22; pfam13309 198628012640 putative metal dependent hydrolase; Provisional; Region: PRK11598 198628012641 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 198628012642 Sulfatase; Region: Sulfatase; pfam00884 198628012643 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 198628012644 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 198628012645 active site 198628012646 phosphorylation site [posttranslational modification] 198628012647 intermolecular recognition site; other site 198628012648 dimerization interface [polypeptide binding]; other site 198628012649 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 198628012650 DNA binding site [nucleotide binding] 198628012651 sensor protein BasS/PmrB; Provisional; Region: PRK10755 198628012652 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 198628012653 dimer interface [polypeptide binding]; other site 198628012654 phosphorylation site [posttranslational modification] 198628012655 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 198628012656 ATP binding site [chemical binding]; other site 198628012657 Mg2+ binding site [ion binding]; other site 198628012658 G-X-G motif; other site 198628012659 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK10902 198628012660 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 198628012661 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 198628012662 SlyX; Region: SlyX; cl01090 198628012663 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 198628012664 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 198628012665 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 198628012666 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 198628012667 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 198628012668 active site 198628012669 substrate binding site [chemical binding]; other site 198628012670 ATP binding site [chemical binding]; other site 198628012671 ethanolamine permease; Region: 2A0305; TIGR00908 198628012672 bicupin, oxalate decarboxylase family; Region: bicupin_oxalic; TIGR03404 198628012673 Cupin; Region: Cupin_1; smart00835 198628012674 Cupin; Region: Cupin_1; smart00835 198628012675 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 198628012676 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 198628012677 Probable metal-binding protein (DUF2387); Region: DUF2387; pfam09526 198628012678 glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659 198628012679 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 198628012680 TrkA-N domain; Region: TrkA_N; pfam02254 198628012681 glutathione-regulated potassium-efflux system ancillary protein KefG; Provisional; Region: PRK04930 198628012682 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 198628012683 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 198628012684 Walker A/P-loop; other site 198628012685 ATP binding site [chemical binding]; other site 198628012686 Q-loop/lid; other site 198628012687 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 198628012688 ABC transporter; Region: ABC_tran_2; pfam12848 198628012689 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 198628012690 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 198628012691 putative hydrolase; Provisional; Region: PRK10985 198628012692 hypothetical protein; Provisional; Region: PRK04966 198628012693 phosphoribulokinase; Provisional; Region: PRK15453 198628012694 active site 198628012695 hypothetical protein; Provisional; Region: PRK10738 198628012696 DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753 198628012697 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 198628012698 ligand binding site [chemical binding]; other site 198628012699 flexible hinge region; other site 198628012700 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 198628012701 putative switch regulator; other site 198628012702 non-specific DNA interactions [nucleotide binding]; other site 198628012703 DNA binding site [nucleotide binding] 198628012704 sequence specific DNA binding site [nucleotide binding]; other site 198628012705 putative cAMP binding site [chemical binding]; other site 198628012706 bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093 198628012707 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 198628012708 inhibitor-cofactor binding pocket; inhibition site 198628012709 pyridoxal 5'-phosphate binding site [chemical binding]; other site 198628012710 catalytic residue [active] 198628012711 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 198628012712 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 198628012713 glutamine binding [chemical binding]; other site 198628012714 catalytic triad [active] 198628012715 Domain of unknown function (DUF3482); Region: DUF3482; pfam11981 198628012716 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 198628012717 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 198628012718 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 198628012719 active site 198628012720 catalytic residues [active] 198628012721 cyanobactin maturation protease, PatA/PatG family; Region: protease_PatA; TIGR03895 198628012722 Predicted chitinase [General function prediction only]; Region: COG3179 198628012723 catalytic residue [active] 198628012724 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198628012725 Major Facilitator Superfamily; Region: MFS_1; pfam07690 198628012726 putative substrate translocation pore; other site 198628012727 Neurotransmitter-gated ion-channel ligand binding domain; Region: Neur_chan_LBD; pfam02931 198628012728 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 198628012729 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 198628012730 catalytic residue [active] 198628012731 Pectate lyase; Region: Pec_lyase_C; pfam00544 198628012732 Pectate lyase; Region: Pec_lyase_C; cl01593 198628012733 peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903 198628012734 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 198628012735 substrate binding site [chemical binding]; other site 198628012736 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 198628012737 Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 4. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_4; cd03329 198628012738 putative active site pocket [active] 198628012739 metal binding site [ion binding]; metal-binding site 198628012740 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 198628012741 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 198628012742 active site 198628012743 HIGH motif; other site 198628012744 dimer interface [polypeptide binding]; other site 198628012745 KMSKS motif; other site 198628012746 phosphoglycolate phosphatase; Provisional; Region: PRK13222 198628012747 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 198628012748 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 198628012749 motif II; other site 198628012750 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 198628012751 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 198628012752 substrate binding site [chemical binding]; other site 198628012753 hexamer interface [polypeptide binding]; other site 198628012754 metal binding site [ion binding]; metal-binding site 198628012755 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 198628012756 hypothetical protein; Reviewed; Region: PRK11901 198628012757 cell division protein DamX; Validated; Region: PRK10905 198628012758 cell division protein DamX; Validated; Region: PRK10905 198628012759 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 198628012760 active site 198628012761 dimer interface [polypeptide binding]; other site 198628012762 metal binding site [ion binding]; metal-binding site 198628012763 shikimate kinase; Reviewed; Region: aroK; PRK00131 198628012764 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 198628012765 ADP binding site [chemical binding]; other site 198628012766 magnesium binding site [ion binding]; other site 198628012767 putative shikimate binding site; other site 198628012768 putative outer membrane porin HofQ; Provisional; Region: hofQ; PRK13568 198628012769 Secretin and TonB N terminus short domain; Region: STN; smart00965 198628012770 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 198628012771 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 198628012772 Protein of unknown function (DUF2531); Region: DUF2531; pfam10748 198628012773 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 198628012774 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 198628012775 penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636 198628012776 Transglycosylase; Region: Transgly; pfam00912 198628012777 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 198628012778 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 198628012779 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 198628012780 ADP-ribose binding site [chemical binding]; other site 198628012781 dimer interface [polypeptide binding]; other site 198628012782 active site 198628012783 nudix motif; other site 198628012784 metal binding site [ion binding]; metal-binding site 198628012785 Intracellular growth attenuator protein IgaA; Region: IgaA; pfam07095 198628012786 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 198628012787 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 198628012788 motif II; other site 198628012789 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 198628012790 RNA binding surface [nucleotide binding]; other site 198628012791 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 198628012792 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 198628012793 dimerization interface [polypeptide binding]; other site 198628012794 domain crossover interface; other site 198628012795 redox-dependent activation switch; other site 198628012796 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 198628012797 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 198628012798 active site 198628012799 substrate-binding site [chemical binding]; other site 198628012800 metal-binding site [ion binding] 198628012801 ATP binding site [chemical binding]; other site 198628012802 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 198628012803 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 198628012804 dimerization interface [polypeptide binding]; other site 198628012805 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 198628012806 dimer interface [polypeptide binding]; other site 198628012807 phosphorylation site [posttranslational modification] 198628012808 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 198628012809 ATP binding site [chemical binding]; other site 198628012810 G-X-G motif; other site 198628012811 osmolarity response regulator; Provisional; Region: ompR; PRK09468 198628012812 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 198628012813 active site 198628012814 phosphorylation site [posttranslational modification] 198628012815 intermolecular recognition site; other site 198628012816 dimerization interface [polypeptide binding]; other site 198628012817 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 198628012818 DNA binding site [nucleotide binding] 198628012819 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 198628012820 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 198628012821 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 198628012822 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ACT14924; Region: LPLAT_ACT14924-like; cd07986 198628012823 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 198628012824 putative acyl-acceptor binding pocket; other site 198628012825 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444 198628012826 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 198628012827 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 198628012828 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 198628012829 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 198628012830 RNA binding site [nucleotide binding]; other site 198628012831 carboxylesterase BioH; Provisional; Region: PRK10349 198628012832 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 198628012833 DNA utilization protein GntX; Provisional; Region: PRK11595 198628012834 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 198628012835 active site 198628012836 Fe/S biogenesis protein NfuA; Provisional; Region: PRK11190 198628012837 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 198628012838 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 198628012839 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 198628012840 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 198628012841 maltodextrin phosphorylase; Provisional; Region: PRK14985 198628012842 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 198628012843 active site pocket [active] 198628012844 DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906 198628012845 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 198628012846 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 198628012847 intramembrane serine protease GlpG; Provisional; Region: PRK10907 198628012848 Protein of unknown function (DUF3582); Region: DUF3582; pfam12122 198628012849 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 198628012850 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 198628012851 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 198628012852 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 198628012853 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 198628012854 substrate binding site [chemical binding]; other site 198628012855 dimer interface [polypeptide binding]; other site 198628012856 ATP binding site [chemical binding]; other site 198628012857 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 198628012858 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 198628012859 inhibitor site; inhibition site 198628012860 active site 198628012861 dimer interface [polypeptide binding]; other site 198628012862 catalytic residue [active] 198628012863 Domain of unknown function (DUF386); Region: DUF386; pfam04074 198628012864 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198628012865 D-galactonate transporter; Region: 2A0114; TIGR00893 198628012866 putative substrate translocation pore; other site 198628012867 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290 198628012868 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 198628012869 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 198628012870 active site residue [active] 198628012871 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 198628012872 glycogen phosphorylase; Provisional; Region: PRK14986 198628012873 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 198628012874 homodimer interface [polypeptide binding]; other site 198628012875 active site pocket [active] 198628012876 glycogen synthase; Provisional; Region: glgA; PRK00654 198628012877 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 198628012878 ADP-binding pocket [chemical binding]; other site 198628012879 homodimer interface [polypeptide binding]; other site 198628012880 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 198628012881 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 198628012882 ligand binding site; other site 198628012883 oligomer interface; other site 198628012884 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 198628012885 sulfate 1 binding site; other site 198628012886 glycogen debranching enzyme; Provisional; Region: PRK03705 198628012887 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 198628012888 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 198628012889 active site 198628012890 catalytic site [active] 198628012891 glycogen branching enzyme; Provisional; Region: PRK05402 198628012892 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 198628012893 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 198628012894 active site 198628012895 catalytic site [active] 198628012896 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 198628012897 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 198628012898 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 198628012899 GAF domain; Region: GAF; pfam01590 198628012900 Histidine kinase; Region: His_kinase; pfam06580 198628012901 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 198628012902 ATP binding site [chemical binding]; other site 198628012903 Mg2+ binding site [ion binding]; other site 198628012904 G-X-G motif; other site 198628012905 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 198628012906 DNA-binding site [nucleotide binding]; DNA binding site 198628012907 RNA-binding motif; other site 198628012908 nickel responsive regulator; Provisional; Region: PRK02967 198628012909 NikR C terminal nickel binding domain; Region: NikR_C; pfam08753 198628012910 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 198628012911 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 198628012912 putative antibiotic transporter; Provisional; Region: PRK10739 198628012913 high-affinity gluconate transporter; Provisional; Region: PRK14984 198628012914 gluconate transporter; Region: gntP; TIGR00791 198628012915 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 198628012916 ATP-binding site [chemical binding]; other site 198628012917 Gluconate-6-phosphate binding site [chemical binding]; other site 198628012918 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 198628012919 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 198628012920 DNA binding site [nucleotide binding] 198628012921 domain linker motif; other site 198628012922 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 198628012923 putative ligand binding site [chemical binding]; other site 198628012924 putative dimerization interface [polypeptide binding]; other site 198628012925 Pirin-related protein [General function prediction only]; Region: COG1741 198628012926 Pirin; Region: Pirin; pfam02678 198628012927 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 198628012928 complex repetitive region downstream of ryhB 198628012929 glycerol-3-phosphate dehydrogenase, anaerobic, C subunit; Region: glycerol3P_GlpC; TIGR03379 198628012930 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 198628012931 Cysteine-rich domain; Region: CCG; pfam02754 198628012932 Cysteine-rich domain; Region: CCG; pfam02754 198628012933 anaerobic glycerol-3-phosphate dehydrogenase subunit B; Validated; Region: PRK05329 198628012934 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 198628012935 sn-glycerol-3-phosphate dehydrogenase subunit A; Provisional; Region: glpA; PRK11101 198628012936 hydroxyglutarate oxidase; Provisional; Region: PRK11728 198628012937 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 198628012938 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 198628012939 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198628012940 putative substrate translocation pore; other site 198628012941 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 198628012942 Glycerophosphodiester phosphodiesterase domain of Escherichia coli (GlpQ) and similar proteins; Region: GDPD_EcGlpQ_like; cd08600 198628012943 active site 198628012944 catalytic site [active] 198628012945 metal binding site [ion binding]; metal-binding site 198628012946 putative hydrolase; Provisional; Region: PRK10976 198628012947 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 198628012948 lysophospholipase L2; Provisional; Region: PRK10749 198628012949 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 198628012950 homoserine/homoserine lactone efflux protein; Provisional; Region: rhtB; PRK10520 198628012951 LysE type translocator; Region: LysE; cl00565 198628012952 ATP-dependent DNA helicase RecQ; Provisional; Region: PRK11057 198628012953 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 198628012954 ATP binding site [chemical binding]; other site 198628012955 putative Mg++ binding site [ion binding]; other site 198628012956 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 198628012957 nucleotide binding region [chemical binding]; other site 198628012958 ATP-binding site [chemical binding]; other site 198628012959 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 198628012960 HRDC domain; Region: HRDC; pfam00570 198628012961 The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541 198628012962 dimerization interface [polypeptide binding]; other site 198628012963 substrate binding site [chemical binding]; other site 198628012964 active site 198628012965 calcium binding site [ion binding]; other site 198628012966 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 198628012967 CoenzymeA binding site [chemical binding]; other site 198628012968 subunit interaction site [polypeptide binding]; other site 198628012969 PHB binding site; other site 198628012970 putative chloramphenical resistance permease RarD; Provisional; Region: PRK15430 198628012971 EamA-like transporter family; Region: EamA; pfam00892 198628012972 Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180 198628012973 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 198628012974 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 198628012975 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 198628012976 Escherichia coli Mg2+ transporter CorA_like subgroup; Region: EcCorA-like_1; cd12835 198628012977 Cl binding site [ion binding]; other site 198628012978 oligomer interface [polypeptide binding]; other site 198628012979 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 198628012980 Part of AAA domain; Region: AAA_19; pfam13245 198628012981 Family description; Region: UvrD_C_2; pfam13538 198628012982 flavin mononucleotide phosphatase; Provisional; Region: PRK10748 198628012983 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 198628012984 motif II; other site 198628012985 Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973 198628012986 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 198628012987 active site 198628012988 DNA binding site [nucleotide binding] 198628012989 Int/Topo IB signature motif; other site 198628012990 hypothetical protein; Provisional; Region: PRK10963 198628012991 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 198628012992 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 198628012993 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 198628012994 Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cd00503 198628012995 putative iron binding site [ion binding]; other site 198628012996 adenylate cyclase; Provisional; Region: cyaA; PRK09450 198628012997 Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633 198628012998 Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295 198628012999 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 198628013000 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 198628013001 domain interfaces; other site 198628013002 active site 198628013003 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 198628013004 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 198628013005 active site 198628013006 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 198628013007 Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemX; COG2959 198628013008 putative protoheme IX biogenesis protein; Provisional; Region: PRK10747 198628013009 HemY protein N-terminus; Region: HemY_N; pfam07219 198628013010 M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669 198628013011 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 198628013012 metal binding site [ion binding]; metal-binding site 198628013013 dimer interface [polypeptide binding]; other site 198628013014 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 198628013015 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 198628013016 Walker A/P-loop; other site 198628013017 ATP binding site [chemical binding]; other site 198628013018 Q-loop/lid; other site 198628013019 ABC transporter signature motif; other site 198628013020 Walker B; other site 198628013021 D-loop; other site 198628013022 H-loop/switch region; other site 198628013023 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198628013024 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 198628013025 dimer interface [polypeptide binding]; other site 198628013026 conserved gate region; other site 198628013027 putative PBP binding loops; other site 198628013028 ABC-ATPase subunit interface; other site 198628013029 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 198628013030 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 198628013031 substrate binding pocket [chemical binding]; other site 198628013032 membrane-bound complex binding site; other site 198628013033 hinge residues; other site 198628013034 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 198628013035 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 198628013036 Coenzyme A binding pocket [chemical binding]; other site 198628013037 prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597 198628013038 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 198628013039 tetramer interface [polypeptide binding]; other site 198628013040 active site 198628013041 Helix-turn-helix domain; Region: HTH_18; pfam12833 198628013042 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 198628013043 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198628013044 Major Facilitator Superfamily; Region: MFS_1; pfam07690 198628013045 amidase; Provisional; Region: PRK07869 198628013046 Amidase; Region: Amidase; cl11426 198628013047 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 198628013048 putative transport protein YifK; Provisional; Region: PRK10746 198628013049 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 198628013050 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 198628013051 putative common antigen polymerase; Provisional; Region: PRK02975 198628013052 4-alpha-L-fucosyltransferase glycosyl transferase group 56; Region: Glyco_transf_56; cl07929 198628013053 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 198628013054 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_10; cd13125 198628013055 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 198628013056 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 198628013057 inhibitor-cofactor binding pocket; inhibition site 198628013058 pyridoxal 5'-phosphate binding site [chemical binding]; other site 198628013059 catalytic residue [active] 198628013060 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 198628013061 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 198628013062 Coenzyme A binding pocket [chemical binding]; other site 198628013063 UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064 198628013064 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 198628013065 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 198628013066 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 198628013067 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 198628013068 active site 198628013069 homodimer interface [polypeptide binding]; other site 198628013070 lipopolysaccharide biosynthesis protein WzzE; Provisional; Region: PRK11638 198628013071 Chain length determinant protein; Region: Wzz; pfam02706 198628013072 undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase; Provisional; Region: PRK15119 198628013073 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 198628013074 Mg++ binding site [ion binding]; other site 198628013075 putative catalytic motif [active] 198628013076 substrate binding site [chemical binding]; other site 198628013077 transcription termination factor Rho; Provisional; Region: rho; PRK09376 198628013078 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 198628013079 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 198628013080 RNA binding site [nucleotide binding]; other site 198628013081 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 198628013082 multimer interface [polypeptide binding]; other site 198628013083 Walker A motif; other site 198628013084 ATP binding site [chemical binding]; other site 198628013085 Walker B motif; other site 198628013086 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 198628013087 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 198628013088 catalytic residues [active] 198628013089 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 198628013090 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 198628013091 ATP binding site [chemical binding]; other site 198628013092 Mg++ binding site [ion binding]; other site 198628013093 motif III; other site 198628013094 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 198628013095 nucleotide binding region [chemical binding]; other site 198628013096 ATP-binding site [chemical binding]; other site 198628013097 guanosine pentaphosphate phosphohydrolase; Provisional; Region: PRK11031 198628013098 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 198628013099 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 198628013100 Interdomain contacts; other site 198628013101 Cytokine receptor motif; other site 198628013102 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 198628013103 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 198628013104 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 198628013105 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 198628013106 Glycosyl hydrolases family 28; Region: Glyco_hydro_28; pfam00295 198628013107 Fibronectin type 3 domain; Region: FN3; smart00060 198628013108 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 198628013109 ATP-dependent DNA helicase Rep; Provisional; Region: PRK10919 198628013110 Part of AAA domain; Region: AAA_19; pfam13245 198628013111 Family description; Region: UvrD_C_2; pfam13538 198628013112 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 198628013113 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 198628013114 trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: putA; PRK11809 198628013115 Predicted transcriptional regulator [Transcription]; Region: COG3905 198628013116 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 198628013117 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 198628013118 Glutamate binding site [chemical binding]; other site 198628013119 NAD binding site [chemical binding]; other site 198628013120 catalytic residues [active] 198628013121 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 198628013122 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 198628013123 Na binding site [ion binding]; other site 198628013124 ketol-acid reductoisomerase; Validated; Region: PRK05225 198628013125 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 198628013126 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 198628013127 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 198628013128 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 198628013129 DNA-binding transcriptional regulator IlvY; Provisional; Region: PRK11716 198628013130 The C-terminal substrate binding of LysR-type transcriptional regulator IlvY, which activates the expression of ilvC gene that encoding acetohydroxy acid isomeroreductase for the biosynthesis of branched amino acids; contains the type 2 periplasmic bindin; Region: PBP2_IlvY; cd08430 198628013131 putative dimerization interface [polypeptide binding]; other site 198628013132 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 198628013133 Conserved hypothetical protein (DUF2461); Region: DUF2461; pfam09365 198628013134 threonine dehydratase; Reviewed; Region: PRK09224 198628013135 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 198628013136 tetramer interface [polypeptide binding]; other site 198628013137 pyridoxal 5'-phosphate binding site [chemical binding]; other site 198628013138 catalytic residue [active] 198628013139 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 198628013140 putative Ile/Val binding site [chemical binding]; other site 198628013141 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 198628013142 putative Ile/Val binding site [chemical binding]; other site 198628013143 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 198628013144 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 198628013145 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 198628013146 homodimer interface [polypeptide binding]; other site 198628013147 substrate-cofactor binding pocket; other site 198628013148 catalytic residue [active] 198628013149 acetolactate synthase 2 regulatory subunit; Provisional; Region: ilvM; PRK11152 198628013150 acetolactate synthase 2 catalytic subunit; Reviewed; Region: PRK08978 198628013151 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 198628013152 PYR/PP interface [polypeptide binding]; other site 198628013153 dimer interface [polypeptide binding]; other site 198628013154 TPP binding site [chemical binding]; other site 198628013155 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 198628013156 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 198628013157 TPP-binding site [chemical binding]; other site 198628013158 dimer interface [polypeptide binding]; other site 198628013159 putative sialic acid transporter; Region: 2A0112; TIGR00891 198628013160 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198628013161 putative substrate translocation pore; other site 198628013162 putative ATP-dependent protease; Provisional; Region: PRK09862 198628013163 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 198628013164 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 198628013165 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 198628013166 hypothetical protein; Provisional; Region: PRK11027 198628013167 transcriptional regulator HdfR; Provisional; Region: PRK03601 198628013168 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 198628013169 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 198628013170 dimerization interface [polypeptide binding]; other site 198628013171 protoporphyrinogen oxidase; Provisional; Region: hemG; PRK11104 198628013172 potassium transporter; Provisional; Region: PRK10750 198628013173 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 198628013174 hypothetical protein; Provisional; Region: PRK11568 198628013175 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 198628013176 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 198628013177 proline dipeptidase; Provisional; Region: PRK13607 198628013178 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 198628013179 active site 198628013180 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 198628013181 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 198628013182 substrate binding site [chemical binding]; other site 198628013183 oxyanion hole (OAH) forming residues; other site 198628013184 trimer interface [polypeptide binding]; other site 198628013185 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 198628013186 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 198628013187 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 198628013188 3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947 198628013189 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 198628013190 dimer interface [polypeptide binding]; other site 198628013191 active site 198628013192 Sulphur transport; Region: Sulf_transp; pfam04143 198628013193 Predicted transporter component [General function prediction only]; Region: COG2391 198628013194 Domain of unknown function (DUF4341); Region: DUF4341; pfam14241 198628013195 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 198628013196 dimerization interface [polypeptide binding]; other site 198628013197 putative DNA binding site [nucleotide binding]; other site 198628013198 putative Zn2+ binding site [ion binding]; other site 198628013199 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 198628013200 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 198628013201 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 198628013202 Member of the Rhodanese Homology Domain superfamily. Included in this CD are the Lactococcus lactis NADH oxidase, Bacillus cereus NADH dehydrogenase, and Bacteroides thetaiotaomicron pyridine nucleotide-disulphide oxidoreductase, and similar...; Region: RHOD_Pyr_redox; cd01524 198628013203 active site residue [active] 198628013204 FMN reductase; Validated; Region: fre; PRK08051 198628013205 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 198628013206 FAD binding pocket [chemical binding]; other site 198628013207 FAD binding motif [chemical binding]; other site 198628013208 phosphate binding motif [ion binding]; other site 198628013209 beta-alpha-beta structure motif; other site 198628013210 NAD binding pocket [chemical binding]; other site 198628013211 internal frameshift split oxidoreductase into two open reading frames, yigC_1 and yigC_2 198628013212 transcriptional activator RfaH; Provisional; Region: rfaH; PRK09014 198628013213 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; Region: NGN_SP_RfaH; cd09892 198628013214 KOW: an acronym for the authors' surnames (Kyrpides, Ouzounis and Woese); Region: KOW; cl00354 198628013215 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 198628013216 dimer interface [polypeptide binding]; other site 198628013217 active site 198628013218 aspartate-rich active site metal binding site; other site 198628013219 allosteric magnesium binding site [ion binding]; other site 198628013220 Schiff base residues; other site 198628013221 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 198628013222 active site 198628013223 twin-arginine protein translocation system subunit TatC; Provisional; Region: PRK10921 198628013224 sec-independent translocase; Provisional; Region: PRK01770 198628013225 twin arginine translocase protein A; Provisional; Region: tatA; PRK04598 198628013226 putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750 198628013227 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 198628013228 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 198628013229 SCP-2 sterol transfer family; Region: SCP2; pfam02036 198628013230 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 198628013231 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 198628013232 S-adenosylmethionine binding site [chemical binding]; other site 198628013233 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 198628013234 Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322 198628013235 RmuC family; Region: RmuC; pfam02646 198628013236 argininosuccinate lyase; Provisional; Region: PRK04833 198628013237 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 198628013238 active sites [active] 198628013239 tetramer interface [polypeptide binding]; other site 198628013240 AAK_NAGK-NC: N-Acetyl-L-glutamate kinase - noncyclic (NAGK-NC) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of microbial arginine biosynthesis using the acetylated, noncyclic route of...; Region: AAK_NAGK-NC; cd04249 198628013241 nucleotide binding site [chemical binding]; other site 198628013242 N-acetyl-L-glutamate binding site [chemical binding]; other site 198628013243 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 198628013244 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 198628013245 acetylornithine deacetylase; Provisional; Region: PRK05111 198628013246 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 198628013247 metal binding site [ion binding]; metal-binding site 198628013248 putative dimer interface [polypeptide binding]; other site 198628013249 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 198628013250 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 198628013251 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 198628013252 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 198628013253 uridine phosphorylase; Provisional; Region: PRK11178 198628013254 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 198628013255 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 198628013256 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 198628013257 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 198628013258 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 198628013259 THF binding site; other site 198628013260 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 198628013261 substrate binding site [chemical binding]; other site 198628013262 THF binding site; other site 198628013263 zinc-binding site [ion binding]; other site 198628013264 DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421 198628013265 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 198628013266 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 198628013267 putative dimerization interface [polypeptide binding]; other site 198628013268 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 198628013269 phospholipid:lipid A palmitoyltransferase; Provisional; Region: pagP; PRK11045 198628013270 serine acetyltransferase; Provisional; Region: cysE; PRK11132 198628013271 Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426 198628013272 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 198628013273 trimer interface [polypeptide binding]; other site 198628013274 active site 198628013275 substrate binding site [chemical binding]; other site 198628013276 CoA binding site [chemical binding]; other site 198628013277 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 198628013278 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 198628013279 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 198628013280 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557 198628013281 SecA binding site; other site 198628013282 Preprotein binding site; other site 198628013283 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 198628013284 active site residue [active] 198628013285 AmiB activator; Provisional; Region: PRK11637 198628013286 Peptidase family M23; Region: Peptidase_M23; pfam01551 198628013287 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 198628013288 putative active site [active] 198628013289 NodB motif; other site 198628013290 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 198628013291 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 198628013292 NAD(P) binding site [chemical binding]; other site 198628013293 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 198628013294 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 198628013295 substrate-cofactor binding pocket; other site 198628013296 pyridoxal 5'-phosphate binding site [chemical binding]; other site 198628013297 catalytic residue [active] 198628013298 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 198628013299 ADP-L-glycero-D-mannoheptose-6-epimerase; Provisional; Region: rfaD; PRK11150 198628013300 NADP binding site [chemical binding]; other site 198628013301 homopentamer interface [polypeptide binding]; other site 198628013302 substrate binding site [chemical binding]; other site 198628013303 active site 198628013304 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 198628013305 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 198628013306 putative active site [active] 198628013307 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 198628013308 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 198628013309 putative active site [active] 198628013310 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 198628013311 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 198628013312 putative active site [active] 198628013313 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 198628013314 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 198628013315 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 198628013316 O-Antigen ligase; Region: Wzy_C; pfam04932 198628013317 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 198628013318 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 198628013319 putative active site [active] 198628013320 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 198628013321 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 198628013322 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 198628013323 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 198628013324 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 198628013325 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 198628013326 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 198628013327 putative metal binding site; other site 198628013328 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 198628013329 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 198628013330 active site 198628013331 (T/H)XGH motif; other site 198628013332 putative glycosyl transferase; Provisional; Region: PRK10073 198628013333 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 198628013334 active site 198628013335 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 198628013336 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 198628013337 DNA binding site [nucleotide binding] 198628013338 catalytic residue [active] 198628013339 H2TH interface [polypeptide binding]; other site 198628013340 putative catalytic residues [active] 198628013341 turnover-facilitating residue; other site 198628013342 intercalation triad [nucleotide binding]; other site 198628013343 8OG recognition residue [nucleotide binding]; other site 198628013344 putative reading head residues; other site 198628013345 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 198628013346 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 198628013347 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 198628013348 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 198628013349 hypothetical protein; Reviewed; Region: PRK00024 198628013350 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 198628013351 MPN+ (JAMM) motif; other site 198628013352 Zinc-binding site [ion binding]; other site 198628013353 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 198628013354 Flavoprotein; Region: Flavoprotein; pfam02441 198628013355 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 198628013356 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 198628013357 trimer interface [polypeptide binding]; other site 198628013358 active site 198628013359 division inhibitor protein; Provisional; Region: slmA; PRK09480 198628013360 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 198628013361 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 198628013362 active site 198628013363 ribonuclease PH; Reviewed; Region: rph; PRK00173 198628013364 Ribonuclease PH; Region: RNase_PH_bact; cd11362 198628013365 hexamer interface [polypeptide binding]; other site 198628013366 active site 198628013367 Predicted membrane protein [Function unknown]; Region: COG2149 198628013368 Domain of unknown function (DUF202); Region: DUF202; pfam02656 198628013369 Protein of unknown function (DUF1611); Region: DUF1611; pfam07755 198628013370 P-loop ATPase protein family; Region: ATP_bind_2; cl15794 198628013371 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 198628013372 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 198628013373 active site 198628013374 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 198628013375 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 198628013376 Walker A/P-loop; other site 198628013377 ATP binding site [chemical binding]; other site 198628013378 Q-loop/lid; other site 198628013379 ABC transporter signature motif; other site 198628013380 Walker B; other site 198628013381 D-loop; other site 198628013382 H-loop/switch region; other site 198628013383 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 198628013384 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 198628013385 Walker A/P-loop; other site 198628013386 ATP binding site [chemical binding]; other site 198628013387 Q-loop/lid; other site 198628013388 ABC transporter signature motif; other site 198628013389 Walker B; other site 198628013390 D-loop; other site 198628013391 H-loop/switch region; other site 198628013392 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 198628013393 The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499 198628013394 glutathione ABC transporter substrate-binding protein GsiB; Provisional; Region: PRK15413 198628013395 glutathione ABC transporter permease GsiC; Provisional; Region: PRK15081 198628013396 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198628013397 dimer interface [polypeptide binding]; other site 198628013398 conserved gate region; other site 198628013399 putative PBP binding loops; other site 198628013400 ABC-ATPase subunit interface; other site 198628013401 glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082 198628013402 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 198628013403 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198628013404 dimer interface [polypeptide binding]; other site 198628013405 conserved gate region; other site 198628013406 putative PBP binding loops; other site 198628013407 ABC-ATPase subunit interface; other site 198628013408 L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253 198628013409 homodimer interface [polypeptide binding]; other site 198628013410 homotetramer interface [polypeptide binding]; other site 198628013411 active site pocket [active] 198628013412 cleavage site 198628013413 Peptidase M55, D-aminopeptidase dipeptide-binding protein family; Region: DAP_dppA_1; cd08663 198628013414 SxDxEG motif; other site 198628013415 active site 198628013416 metal binding site [ion binding]; metal-binding site 198628013417 homopentamer interface [polypeptide binding]; other site 198628013418 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 198628013419 catalytic nucleophile [active] 198628013420 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 198628013421 Beta-lactamase; Region: Beta-lactamase; pfam00144 198628013422 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 198628013423 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 198628013424 Walker A/P-loop; other site 198628013425 ATP binding site [chemical binding]; other site 198628013426 Q-loop/lid; other site 198628013427 ABC transporter signature motif; other site 198628013428 Walker B; other site 198628013429 D-loop; other site 198628013430 H-loop/switch region; other site 198628013431 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 198628013432 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 198628013433 Walker A/P-loop; other site 198628013434 ATP binding site [chemical binding]; other site 198628013435 Q-loop/lid; other site 198628013436 ABC transporter signature motif; other site 198628013437 Walker B; other site 198628013438 D-loop; other site 198628013439 H-loop/switch region; other site 198628013440 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 198628013441 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 198628013442 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 198628013443 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198628013444 dimer interface [polypeptide binding]; other site 198628013445 conserved gate region; other site 198628013446 putative PBP binding loops; other site 198628013447 ABC-ATPase subunit interface; other site 198628013448 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 198628013449 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198628013450 putative PBP binding loops; other site 198628013451 dimer interface [polypeptide binding]; other site 198628013452 ABC-ATPase subunit interface; other site 198628013453 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 198628013454 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 198628013455 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 198628013456 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 198628013457 active site 198628013458 dimer interface [polypeptide binding]; other site 198628013459 Transcriptional regulator [Transcription]; Region: LysR; COG0583 198628013460 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 198628013461 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 198628013462 dimerization interface [polypeptide binding]; other site 198628013463 hypothetical protein; Provisional; Region: PRK11820 198628013464 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 198628013465 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 198628013466 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 198628013467 non-specific DNA binding site [nucleotide binding]; other site 198628013468 salt bridge; other site 198628013469 sequence-specific DNA binding site [nucleotide binding]; other site 198628013470 Winged helix-turn-helix DNA-binding; Region: HTH_35; pfam13693 198628013471 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 198628013472 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 198628013473 non-specific DNA binding site [nucleotide binding]; other site 198628013474 salt bridge; other site 198628013475 sequence-specific DNA binding site [nucleotide binding]; other site 198628013476 Predicted chitinase [General function prediction only]; Region: COG3179 198628013477 catalytic residue [active] 198628013478 Protein of unknown function (DUF3150); Region: DUF3150; pfam11348 198628013479 Uncharacterized conserved protein [Function unknown]; Region: COG4104 198628013480 Protein of unknown function (DUF1471); Region: DUF1471; cl11507 198628013481 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 198628013482 Interdomain contacts; other site 198628013483 Cytokine receptor motif; other site 198628013484 Autoinducer synthetase; Region: Autoind_synth; pfam00765 198628013485 Autoinducer binding domain; Region: Autoind_bind; pfam03472 198628013486 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 198628013487 DNA binding residues [nucleotide binding] 198628013488 dimerization interface [polypeptide binding]; other site 198628013489 pyridoxal-dependent decarboxylase, exosortase A system-associated; Region: dCO2ase_PEP1; TIGR03099 198628013490 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Btrk Decarboxylase; Region: PLPDE_III_Btrk_like; cd06839 198628013491 dimer interface [polypeptide binding]; other site 198628013492 active site 198628013493 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 198628013494 catalytic residues [active] 198628013495 substrate binding site [chemical binding]; other site 198628013496 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 198628013497 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 198628013498 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 198628013499 acyl-activating enzyme (AAE) consensus motif; other site 198628013500 acyl-activating enzyme (AAE) consensus motif; other site 198628013501 AMP binding site [chemical binding]; other site 198628013502 active site 198628013503 CoA binding site [chemical binding]; other site 198628013504 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 198628013505 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 198628013506 acyl-activating enzyme (AAE) consensus motif; other site 198628013507 AMP binding site [chemical binding]; other site 198628013508 active site 198628013509 CoA binding site [chemical binding]; other site 198628013510 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 198628013511 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 198628013512 acyl-activating enzyme (AAE) consensus motif; other site 198628013513 AMP binding site [chemical binding]; other site 198628013514 active site 198628013515 CoA binding site [chemical binding]; other site 198628013516 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 198628013517 active site 198628013518 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 198628013519 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 198628013520 active site 198628013521 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal; Region: ACP_syn_III_C; pfam08541 198628013522 cyclohexanecarboxyl-CoA dehydrogenase; Region: cyc_hxne_CoA_dh; TIGR03207 198628013523 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 198628013524 active site 198628013525 NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691 198628013526 Protein of unknown function (DUF2807); Region: DUF2807; pfam10988 198628013527 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 198628013528 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 198628013529 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 198628013530 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 198628013531 ATP binding site [chemical binding]; other site 198628013532 Mg2+ binding site [ion binding]; other site 198628013533 G-X-G motif; other site 198628013534 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 198628013535 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 198628013536 active site 198628013537 phosphorylation site [posttranslational modification] 198628013538 intermolecular recognition site; other site 198628013539 dimerization interface [polypeptide binding]; other site 198628013540 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 198628013541 Walker A motif; other site 198628013542 ATP binding site [chemical binding]; other site 198628013543 Walker B motif; other site 198628013544 arginine finger; other site 198628013545 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 198628013546 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 198628013547 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 198628013548 FtsX-like permease family; Region: FtsX; pfam02687 198628013549 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 198628013550 FtsX-like permease family; Region: FtsX; pfam02687 198628013551 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 198628013552 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 198628013553 Walker A/P-loop; other site 198628013554 ATP binding site [chemical binding]; other site 198628013555 Q-loop/lid; other site 198628013556 ABC transporter signature motif; other site 198628013557 Walker B; other site 198628013558 D-loop; other site 198628013559 H-loop/switch region; other site 198628013560 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 198628013561 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 198628013562 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 198628013563 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 198628013564 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 198628013565 acyl carrier protein; Provisional; Region: PRK07639 198628013566 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 198628013567 active site 198628013568 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 198628013569 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 198628013570 acyl-activating enzyme (AAE) consensus motif; other site 198628013571 AMP binding site [chemical binding]; other site 198628013572 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 198628013573 putative FMN binding site [chemical binding]; other site 198628013574 NADPH bind site [chemical binding]; other site 198628013575 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 198628013576 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 198628013577 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 198628013578 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 198628013579 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 198628013580 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 198628013581 motif II; other site 198628013582 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 198628013583 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 198628013584 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 198628013585 MarR family; Region: MarR; pfam01047 198628013586 argininosuccinate synthase; Validated; Region: PRK05370 198628013587 nickel/cobalt efflux protein RcnA; Provisional; Region: PRK10019 198628013588 High-affinity nickel-transport protein; Region: NicO; cl00964 198628013589 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 198628013590 putative metal binding site [ion binding]; other site 198628013591 putative homodimer interface [polypeptide binding]; other site 198628013592 putative homotetramer interface [polypeptide binding]; other site 198628013593 putative homodimer-homodimer interface [polypeptide binding]; other site 198628013594 putative allosteric switch controlling residues; other site 198628013595 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 198628013596 DJ-1 family protein; Region: not_thiJ; TIGR01383 198628013597 conserved cys residue [active] 198628013598 Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543 198628013599 putative dimerization interface [polypeptide binding]; other site 198628013600 Transcriptional regulators [Transcription]; Region: PurR; COG1609 198628013601 putative ligand binding site [chemical binding]; other site 198628013602 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 198628013603 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 198628013604 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 198628013605 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 198628013606 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 198628013607 TM-ABC transporter signature motif; other site 198628013608 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 198628013609 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 198628013610 Walker A/P-loop; other site 198628013611 ATP binding site [chemical binding]; other site 198628013612 Q-loop/lid; other site 198628013613 ABC transporter signature motif; other site 198628013614 Walker B; other site 198628013615 D-loop; other site 198628013616 H-loop/switch region; other site 198628013617 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 198628013618 D-xylose transporter subunit XylF; Provisional; Region: xylF; PRK10355 198628013619 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 198628013620 putative ligand binding site [chemical binding]; other site 198628013621 xylose isomerase; Provisional; Region: PRK05474 198628013622 xylose isomerase; Region: xylose_isom_A; TIGR02630 198628013623 xylulokinase; Provisional; Region: PRK15027 198628013624 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 198628013625 N- and C-terminal domain interface [polypeptide binding]; other site 198628013626 active site 198628013627 MgATP binding site [chemical binding]; other site 198628013628 catalytic site [active] 198628013629 metal binding site [ion binding]; metal-binding site 198628013630 xylulose binding site [chemical binding]; other site 198628013631 homodimer interface [polypeptide binding]; other site 198628013632 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 198628013633 Transposase; Region: DEDD_Tnp_IS110; pfam01548 198628013634 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 198628013635 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 198628013636 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 198628013637 NAD(P) binding site [chemical binding]; other site 198628013638 catalytic residues [active] 198628013639 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 198628013640 superoxide dismutase; Provisional; Region: PRK10925 198628013641 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 198628013642 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 198628013643 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 198628013644 dimerization interface [polypeptide binding]; other site 198628013645 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 198628013646 dimer interface [polypeptide binding]; other site 198628013647 putative CheW interface [polypeptide binding]; other site 198628013648 Transcriptional regulator [Transcription]; Region: MtlR; COG3722 198628013649 mannitol repressor protein; Provisional; Region: mtlR; PRK11001 198628013650 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 198628013651 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 198628013652 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 198628013653 PTS system mannitol-specific transporter subunit IICBA; Provisional; Region: PRK15083 198628013654 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 198628013655 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 198628013656 active site 198628013657 P-loop; other site 198628013658 phosphorylation site [posttranslational modification] 198628013659 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 198628013660 active site 198628013661 phosphorylation site [posttranslational modification] 198628013662 Protein of unknown function (DUF3053); Region: DUF3053; pfam11254 198628013663 ABC transporter periplasmic binding protein, urea carboxylase region; Region: ABC_peri_uca; TIGR03427 198628013664 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 198628013665 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198628013666 putative PBP binding loops; other site 198628013667 dimer interface [polypeptide binding]; other site 198628013668 ABC-ATPase subunit interface; other site 198628013669 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 198628013670 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 198628013671 Walker A/P-loop; other site 198628013672 ATP binding site [chemical binding]; other site 198628013673 Q-loop/lid; other site 198628013674 ABC transporter signature motif; other site 198628013675 Walker B; other site 198628013676 D-loop; other site 198628013677 H-loop/switch region; other site 198628013678 urea carboxylase-associated protein 2; Region: urea_degr_2; TIGR03425 198628013679 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 198628013680 Domain of unknown function (DUF1989); Region: DUF1989; pfam09347 198628013681 urea carboxylase; Region: urea_carbox; TIGR02712 198628013682 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 198628013683 ATP-grasp domain; Region: ATP-grasp_4; cl17255 198628013684 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 198628013685 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 198628013686 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 198628013687 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 198628013688 carboxyltransferase (CT) interaction site; other site 198628013689 biotinylation site [posttranslational modification]; other site 198628013690 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 198628013691 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198628013692 dimer interface [polypeptide binding]; other site 198628013693 conserved gate region; other site 198628013694 putative PBP binding loops; other site 198628013695 ABC-ATPase subunit interface; other site 198628013696 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198628013697 dimer interface [polypeptide binding]; other site 198628013698 conserved gate region; other site 198628013699 putative PBP binding loops; other site 198628013700 ABC-ATPase subunit interface; other site 198628013701 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 198628013702 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 198628013703 Protein of unknown function, DUF608; Region: DUF608; pfam04685 198628013704 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 198628013705 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 198628013706 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 198628013707 nucleotide binding site [chemical binding]; other site 198628013708 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 198628013709 MarR family; Region: MarR_2; pfam12802 198628013710 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 198628013711 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 198628013712 nucleotide binding site [chemical binding]; other site 198628013713 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 198628013714 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 198628013715 Walker A/P-loop; other site 198628013716 ATP binding site [chemical binding]; other site 198628013717 Q-loop/lid; other site 198628013718 ABC transporter signature motif; other site 198628013719 Walker B; other site 198628013720 D-loop; other site 198628013721 H-loop/switch region; other site 198628013722 TOBE domain; Region: TOBE_2; pfam08402 198628013723 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 198628013724 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 198628013725 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 198628013726 dimer interface [polypeptide binding]; other site 198628013727 motif 1; other site 198628013728 active site 198628013729 motif 2; other site 198628013730 motif 3; other site 198628013731 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 198628013732 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 198628013733 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 198628013734 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 198628013735 Coenzyme A binding pocket [chemical binding]; other site 198628013736 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 198628013737 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 198628013738 dimerization interface [polypeptide binding]; other site 198628013739 ligand binding site [chemical binding]; other site 198628013740 NADP binding site [chemical binding]; other site 198628013741 catalytic site [active] 198628013742 Aldose 1-epimerase, similar to Escherichia coli c4013; Region: Aldose_epim_Ec_c4013; cd09023 198628013743 active site 198628013744 catalytic residues [active] 198628013745 valine--pyruvate transaminase; Provisional; Region: avtA; PRK09440 198628013746 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 198628013747 pyridoxal 5'-phosphate binding site [chemical binding]; other site 198628013748 homodimer interface [polypeptide binding]; other site 198628013749 catalytic residue [active] 198628013750 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 198628013751 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 198628013752 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_15; cd08492 198628013753 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 198628013754 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198628013755 dimer interface [polypeptide binding]; other site 198628013756 conserved gate region; other site 198628013757 putative PBP binding loops; other site 198628013758 ABC-ATPase subunit interface; other site 198628013759 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 198628013760 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198628013761 putative PBP binding loops; other site 198628013762 dimer interface [polypeptide binding]; other site 198628013763 ABC-ATPase subunit interface; other site 198628013764 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 198628013765 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 198628013766 Walker A/P-loop; other site 198628013767 ATP binding site [chemical binding]; other site 198628013768 Q-loop/lid; other site 198628013769 ABC transporter signature motif; other site 198628013770 Walker B; other site 198628013771 D-loop; other site 198628013772 H-loop/switch region; other site 198628013773 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 198628013774 Walker A/P-loop; other site 198628013775 ATP binding site [chemical binding]; other site 198628013776 Q-loop/lid; other site 198628013777 ABC transporter signature motif; other site 198628013778 Walker B; other site 198628013779 D-loop; other site 198628013780 H-loop/switch region; other site 198628013781 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 198628013782 putative FMN-dependent luciferase-like monooxygenase, KPN_01858 family; Region: LLM_KPN_01858; TIGR04027 198628013783 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 198628013784 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950; cl17731 198628013785 alkylhydroperoxidase domain protein, Avi_7169 family; Region: perox_Avi_7169; TIGR04030 198628013786 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 198628013787 glucokinase, proteobacterial type; Region: glk; TIGR00749 198628013788 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 198628013789 nucleotide binding site [chemical binding]; other site 198628013790 Domain of Unknown Function with PDB structure (DUF3861); Region: DUF3861; pfam12977 198628013791 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 198628013792 MarR family; Region: MarR_2; pfam12802 198628013793 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 198628013794 Coenzyme A binding pocket [chemical binding]; other site 198628013795 Transcriptional regulator [Transcription]; Region: LysR; COG0583 198628013796 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 198628013797 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 198628013798 putative dimerization interface [polypeptide binding]; other site 198628013799 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 198628013800 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198628013801 putative substrate translocation pore; other site 198628013802 putative oxalyl-CoA decarboxylase; Validated; Region: PRK09259 198628013803 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 198628013804 PYR/PP interface [polypeptide binding]; other site 198628013805 dimer interface [polypeptide binding]; other site 198628013806 TPP binding site [chemical binding]; other site 198628013807 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 198628013808 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 198628013809 TPP-binding site; other site 198628013810 dimer interface [polypeptide binding]; other site 198628013811 formyl-coenzyme A transferase; Provisional; Region: PRK05398 198628013812 CoA-transferase family III; Region: CoA_transf_3; pfam02515 198628013813 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 198628013814 PAS domain; Region: PAS_9; pfam13426 198628013815 putative active site [active] 198628013816 heme pocket [chemical binding]; other site 198628013817 formyl-coenzyme A transferase; Provisional; Region: PRK05398 198628013818 CoA-transferase family III; Region: CoA_transf_3; pfam02515 198628013819 H+ Antiporter protein; Region: 2A0121; TIGR00900 198628013820 Biofilm formation and stress response factor; Region: BsmA; pfam10014 198628013821 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 198628013822 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 198628013823 Radical SAM superfamily; Region: Radical_SAM; pfam04055 198628013824 FeS/SAM binding site; other site 198628013825 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 198628013826 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 198628013827 catalytic residue [active] 198628013828 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 198628013829 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 198628013830 putative DNA binding site [nucleotide binding]; other site 198628013831 putative Zn2+ binding site [ion binding]; other site 198628013832 AsnC family; Region: AsnC_trans_reg; pfam01037 198628013833 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 198628013834 Uncharacterized conserved protein [Function unknown]; Region: COG1284 198628013835 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 198628013836 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 198628013837 active site 198628013838 oxyanion hole [active] 198628013839 SGNH_peri1; putative periplasmic member of the SGNH-family of hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known...; Region: SGNH_hydrolase_peri1; cd01825 198628013840 active site 198628013841 catalytic triad [active] 198628013842 oxyanion hole [active] 198628013843 SGNH_peri2; putative periplasmic member of the SGNH-family of hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known...; Region: SGNH_hydrolase_peri2; cd01829 198628013844 active site 198628013845 catalytic triad [active] 198628013846 oxyanion hole [active] 198628013847 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 198628013848 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 198628013849 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 198628013850 DNA-binding site [nucleotide binding]; DNA binding site 198628013851 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 198628013852 prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597 198628013853 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 198628013854 tetramer interface [polypeptide binding]; other site 198628013855 active site 198628013856 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 198628013857 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 198628013858 transmembrane helices; other site 198628013859 glutathione reductase; Validated; Region: PRK06116 198628013860 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 198628013861 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 198628013862 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 198628013863 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 198628013864 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 198628013865 Protein of unknown function (DUF2623); Region: DUF2623; pfam11115 198628013866 oligopeptidase A; Provisional; Region: PRK10911 198628013867 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 198628013868 active site 198628013869 Zn binding site [ion binding]; other site 198628013870 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 198628013871 S-adenosylmethionine binding site [chemical binding]; other site 198628013872 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198628013873 Major Facilitator Superfamily; Region: MFS_1; pfam07690 198628013874 putative substrate translocation pore; other site 198628013875 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 198628013876 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 198628013877 Mg2+ binding site [ion binding]; other site 198628013878 G-X-G motif; other site 198628013879 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 198628013880 anchoring element; other site 198628013881 dimer interface [polypeptide binding]; other site 198628013882 ATP binding site [chemical binding]; other site 198628013883 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 198628013884 active site 198628013885 putative metal-binding site [ion binding]; other site 198628013886 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 198628013887 recombination protein F; Reviewed; Region: recF; PRK00064 198628013888 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 198628013889 Walker A/P-loop; other site 198628013890 ATP binding site [chemical binding]; other site 198628013891 Q-loop/lid; other site 198628013892 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 198628013893 ABC transporter signature motif; other site 198628013894 Walker B; other site 198628013895 D-loop; other site 198628013896 H-loop/switch region; other site 198628013897 DNA polymerase III subunit beta; Validated; Region: PRK05643 198628013898 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 198628013899 putative DNA binding surface [nucleotide binding]; other site 198628013900 dimer interface [polypeptide binding]; other site 198628013901 beta-clamp/clamp loader binding surface; other site 198628013902 beta-clamp/translesion DNA polymerase binding surface; other site 198628013903 DnaA N-terminal domain; Region: DnaA_N; pfam11638 198628013904 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 198628013905 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 198628013906 Walker A motif; other site 198628013907 ATP binding site [chemical binding]; other site 198628013908 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 198628013909 Walker B motif; other site 198628013910 arginine finger; other site 198628013911 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 198628013912 DnaA box-binding interface [nucleotide binding]; other site 198628013913 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 198628013914 ribonuclease P; Reviewed; Region: rnpA; PRK01732 198628013915 hypothetical protein; Validated; Region: PRK00041 198628013916 membrane protein insertase; Provisional; Region: PRK01318 198628013917 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 198628013918 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 198628013919 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 198628013920 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 198628013921 trmE is a tRNA modification GTPase; Region: trmE; cd04164 198628013922 G1 box; other site 198628013923 GTP/Mg2+ binding site [chemical binding]; other site 198628013924 Switch I region; other site 198628013925 G2 box; other site 198628013926 Switch II region; other site 198628013927 G3 box; other site 198628013928 G4 box; other site 198628013929 G5 box; other site 198628013930 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 198628013931 HipA N-terminal domain; Region: Couple_hipA; pfam13657 198628013932 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 198628013933 HipA-like N-terminal domain; Region: HipA_N; pfam07805 198628013934 HipA-like C-terminal domain; Region: HipA_C; pfam07804 198628013935 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 198628013936 non-specific DNA binding site [nucleotide binding]; other site 198628013937 salt bridge; other site 198628013938 sequence-specific DNA binding site [nucleotide binding]; other site 198628013939 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 198628013940 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 198628013941 conserved cys residue [active] 198628013942 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 198628013943 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 198628013944 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 198628013945 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 198628013946 4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185 198628013947 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 198628013948 dimer interface [polypeptide binding]; other site 198628013949 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 198628013950 active site 198628013951 Fe binding site [ion binding]; other site 198628013952 Predicted transcriptional regulators [Transcription]; Region: COG1733 198628013953 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 198628013954 dimerization interface [polypeptide binding]; other site 198628013955 putative DNA binding site [nucleotide binding]; other site 198628013956 putative Zn2+ binding site [ion binding]; other site 198628013957 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 198628013958 NADH(P)-binding; Region: NAD_binding_10; pfam13460 198628013959 NAD binding site [chemical binding]; other site 198628013960 substrate binding site [chemical binding]; other site 198628013961 putative active site [active] 198628013962 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 198628013963 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 198628013964 Coenzyme A binding pocket [chemical binding]; other site 198628013965 Transcriptional regulator [Transcription]; Region: LysR; COG0583 198628013966 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 198628013967 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 198628013968 dimerization interface [polypeptide binding]; other site 198628013969 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971 198628013970 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051 198628013971 4-amino-4-deoxy-L-arabinose transferase; Provisional; Region: arnT; PRK13279 198628013972 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 198628013973 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD; Provisional; Region: PRK15394 198628013974 Catalytic domain of Escherichia coli 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD and other bacterial homologs; Region: CE4_ArnD; cd10939 198628013975 putative active site [active] 198628013976 putative catalytic site [active] 198628013977 putative Zn binding site [ion binding]; other site 198628013978 bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase; Validated; Region: PRK08125 198628013979 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 198628013980 active site 198628013981 substrate binding site [chemical binding]; other site 198628013982 cosubstrate binding site; other site 198628013983 catalytic site [active] 198628013984 C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702 198628013985 active site 198628013986 hexamer interface [polypeptide binding]; other site 198628013987 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 198628013988 NAD binding site [chemical binding]; other site 198628013989 substrate binding site [chemical binding]; other site 198628013990 active site 198628013991 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 198628013992 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 198628013993 Ligand binding site; other site 198628013994 Putative Catalytic site; other site 198628013995 DXD motif; other site 198628013996 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 198628013997 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 198628013998 inhibitor-cofactor binding pocket; inhibition site 198628013999 pyridoxal 5'-phosphate binding site [chemical binding]; other site 198628014000 catalytic residue [active] 198628014001 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4380 198628014002 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4259 198628014003 Uncharacterized protein involved in formation of curli polymers [Cell envelope biogenesis, outer membrane]; Region: CsgG; COG1462 198628014004 putative oxidoreductase Fe-S binding subunit; Reviewed; Region: PRK12769 198628014005 4Fe-4S binding domain; Region: Fer4; pfam00037 198628014006 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 198628014007 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 198628014008 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 198628014009 4Fe-4S binding domain; Region: Fer4; pfam00037 198628014010 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 198628014011 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 198628014012 6-phosphogluconate phosphatase; Provisional; Region: PRK10563 198628014013 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 198628014014 motif I; other site 198628014015 active site 198628014016 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198628014017 dimer interface [polypeptide binding]; other site 198628014018 conserved gate region; other site 198628014019 putative PBP binding loops; other site 198628014020 ABC-ATPase subunit interface; other site 198628014021 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198628014022 dimer interface [polypeptide binding]; other site 198628014023 conserved gate region; other site 198628014024 putative PBP binding loops; other site 198628014025 ABC-ATPase subunit interface; other site 198628014026 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 198628014027 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 198628014028 substrate binding pocket [chemical binding]; other site 198628014029 membrane-bound complex binding site; other site 198628014030 hinge residues; other site 198628014031 transcriptional regulator PhoU; Provisional; Region: PRK11115 198628014032 PhoU domain; Region: PhoU; pfam01895 198628014033 PhoU domain; Region: PhoU; pfam01895 198628014034 phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744 198628014035 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 198628014036 Walker A/P-loop; other site 198628014037 ATP binding site [chemical binding]; other site 198628014038 Q-loop/lid; other site 198628014039 ABC transporter signature motif; other site 198628014040 Walker B; other site 198628014041 D-loop; other site 198628014042 H-loop/switch region; other site 198628014043 phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268 198628014044 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198628014045 dimer interface [polypeptide binding]; other site 198628014046 conserved gate region; other site 198628014047 putative PBP binding loops; other site 198628014048 ABC-ATPase subunit interface; other site 198628014049 phosphate transporter permease subunit PstC; Provisional; Region: pstC; PRK11275 198628014050 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 198628014051 dimer interface [polypeptide binding]; other site 198628014052 conserved gate region; other site 198628014053 putative PBP binding loops; other site 198628014054 ABC-ATPase subunit interface; other site 198628014055 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 198628014056 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 198628014057 P-loop; other site 198628014058 Magnesium ion binding site [ion binding]; other site 198628014059 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 198628014060 GAF domain; Region: GAF; pfam01590 198628014061 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 198628014062 PAS fold; Region: PAS_3; pfam08447 198628014063 putative active site [active] 198628014064 heme pocket [chemical binding]; other site 198628014065 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 198628014066 PAS fold; Region: PAS_3; pfam08447 198628014067 putative active site [active] 198628014068 heme pocket [chemical binding]; other site 198628014069 GAF domain; Region: GAF_2; pfam13185 198628014070 GAF domain; Region: GAF_3; pfam13492 198628014071 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 198628014072 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 198628014073 metal binding site [ion binding]; metal-binding site 198628014074 active site 198628014075 I-site; other site 198628014076 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 198628014077 putative substrate translocation pore; other site 198628014078 Major Facilitator Superfamily; Region: MFS_1; pfam07690 198628014079 Methyltransferase domain; Region: Methyltransf_23; pfam13489 198628014080 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 198628014081 S-adenosylmethionine binding site [chemical binding]; other site 198628014082 alpha-L-glutamate ligases, RimK family; Region: rimK_fam; TIGR00768 198628014083 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 198628014084 FOG: WD40 repeat [General function prediction only]; Region: COG2319 198628014085 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 198628014086 structural tetrad; other site 198628014087 FOG: WD40 repeat [General function prediction only]; Region: COG2319 198628014088 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 198628014089 structural tetrad; other site 198628014090 Uncharacterized conserved protein [Function unknown]; Region: COG1262 198628014091 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 198628014092 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 198628014093 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 198628014094 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 198628014095 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 198628014096 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 198628014097 catalytic residue [active] 198628014098 Predicted flavoprotein [General function prediction only]; Region: COG0431 198628014099 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 198628014100 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 198628014101 dimerization interface [polypeptide binding]; other site 198628014102 active site 198628014103 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 198628014104 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 198628014105 glutaminase active site [active] 198628014106 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 198628014107 dimer interface [polypeptide binding]; other site 198628014108 active site 198628014109 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 198628014110 dimer interface [polypeptide binding]; other site 198628014111 active site 198628014112 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK09451 198628014113 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 198628014114 Substrate binding site; other site 198628014115 Mg++ binding site; other site 198628014116 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 198628014117 active site 198628014118 substrate binding site [chemical binding]; other site 198628014119 CoA binding site [chemical binding]; other site 198628014120 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 198628014121 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 198628014122 gamma subunit interface [polypeptide binding]; other site 198628014123 epsilon subunit interface [polypeptide binding]; other site 198628014124 LBP interface [polypeptide binding]; other site 198628014125 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 198628014126 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 198628014127 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 198628014128 alpha subunit interaction interface [polypeptide binding]; other site 198628014129 Walker A motif; other site 198628014130 ATP binding site [chemical binding]; other site 198628014131 Walker B motif; other site 198628014132 inhibitor binding site; inhibition site 198628014133 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 198628014134 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 198628014135 core domain interface [polypeptide binding]; other site 198628014136 delta subunit interface [polypeptide binding]; other site 198628014137 epsilon subunit interface [polypeptide binding]; other site 198628014138 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 198628014139 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 198628014140 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 198628014141 beta subunit interaction interface [polypeptide binding]; other site 198628014142 Walker A motif; other site 198628014143 ATP binding site [chemical binding]; other site 198628014144 Walker B motif; other site 198628014145 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 198628014146 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 198628014147 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 198628014148 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 198628014149 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 198628014150 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 198628014151 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 198628014152 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 198628014153 F0F1 ATP synthase subunit I; Validated; Region: PRK08049 198628014154 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 198628014155 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 198628014156 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 198628014157 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 198628014158 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 198628014159 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932