-- dump date   	20140619_065351
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
590409000001	DnaA N-terminal domain; Region: DnaA_N; pfam11638
590409000002	chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362
590409000003	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
590409000004	Walker A motif; other site
590409000005	ATP binding site [chemical binding]; other site
590409000006	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
590409000007	Walker B motif; other site
590409000008	arginine finger; other site
590409000009	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
590409000010	DnaA box-binding interface [nucleotide binding]; other site
590409000011	DNA polymerase III subunit beta; Validated; Region: PRK05643
590409000012	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
590409000013	putative DNA binding surface [nucleotide binding]; other site
590409000014	dimer interface [polypeptide binding]; other site
590409000015	beta-clamp/clamp loader binding surface; other site
590409000016	beta-clamp/translesion DNA polymerase binding surface; other site
590409000017	recombination protein F; Reviewed; Region: recF; PRK00064
590409000018	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
590409000019	Walker A/P-loop; other site
590409000020	ATP binding site [chemical binding]; other site
590409000021	Q-loop/lid; other site
590409000022	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
590409000023	ABC transporter signature motif; other site
590409000024	Walker B; other site
590409000025	D-loop; other site
590409000026	H-loop/switch region; other site
590409000027	DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939
590409000028	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
590409000029	Mg2+ binding site [ion binding]; other site
590409000030	G-X-G motif; other site
590409000031	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
590409000032	anchoring element; other site
590409000033	dimer interface [polypeptide binding]; other site
590409000034	ATP binding site [chemical binding]; other site
590409000035	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
590409000036	active site
590409000037	putative metal-binding site [ion binding]; other site
590409000038	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
590409000039	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
590409000040	Major Facilitator Superfamily; Region: MFS_1; pfam07690
590409000041	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
590409000042	Major Facilitator Superfamily; Region: MFS_1; pfam07690
590409000043	putative methyltransferase; Provisional; Region: PRK10742
590409000044	oligopeptidase A; Provisional; Region: PRK10911
590409000045	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
590409000046	active site
590409000047	Zn binding site [ion binding]; other site
590409000048	Protein of unknown function (DUF2623); Region: DUF2623; pfam11115
590409000049	Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961
590409000050	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
590409000051	Sigma54-dependent transcription regulator containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: RtcR; COG4650
590409000052	Regulator of RNA terminal phosphate cyclase; Region: RtcR; pfam06956
590409000053	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
590409000054	Walker A motif; other site
590409000055	ATP binding site [chemical binding]; other site
590409000056	Walker B motif; other site
590409000057	arginine finger; other site
590409000058	The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual proteins of this...; Region: Band_7; cl02525
590409000059	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
590409000060	Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139
590409000061	hypothetical protein; Reviewed; Region: PRK09588
590409000062	glutathione reductase; Validated; Region: PRK06116
590409000063	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
590409000064	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
590409000065	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
590409000066	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
590409000067	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625
590409000068	transmembrane helices; other site
590409000069	prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597
590409000070	Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015
590409000071	tetramer interface [polypeptide binding]; other site
590409000072	active site
590409000073	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
590409000074	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
590409000075	DNA-binding site [nucleotide binding]; DNA binding site
590409000076	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
590409000077	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
590409000078	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
590409000079	Uncharacterized conserved protein [Function unknown]; Region: COG1284
590409000080	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
590409000081	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
590409000082	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
590409000083	putative DNA binding site [nucleotide binding]; other site
590409000084	putative Zn2+ binding site [ion binding]; other site
590409000085	AsnC family; Region: AsnC_trans_reg; pfam01037
590409000086	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
590409000087	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
590409000088	catalytic residue [active]
590409000089	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
590409000090	Radical SAM superfamily; Region: Radical_SAM; pfam04055
590409000091	FeS/SAM binding site; other site
590409000092	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
590409000093	Biofilm formation and stress response factor; Region: BsmA; pfam10014
590409000094	H+ Antiporter protein; Region: 2A0121; TIGR00900
590409000095	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
590409000096	Coenzyme A binding pocket [chemical binding]; other site
590409000097	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
590409000098	MarR family; Region: MarR_2; cl17246
590409000099	Domain of Unknown Function with PDB structure (DUF3861); Region: DUF3861; pfam12977
590409000100	glucokinase, proteobacterial type; Region: glk; TIGR00749
590409000101	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
590409000102	nucleotide binding site [chemical binding]; other site
590409000103	NIPSNAP; Region: NIPSNAP; pfam07978
590409000104	CMD domain protein, Avi_7170 family; Region: CMD_Avi_7170; TIGR04029
590409000105	alkylhydroperoxidase domain protein, Avi_7169 family; Region: perox_Avi_7169; TIGR04030
590409000106	uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926
590409000107	putative FMN-dependent luciferase-like monooxygenase, KPN_01858 family; Region: LLM_KPN_01858; TIGR04027
590409000108	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
590409000109	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
590409000110	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
590409000111	Walker A/P-loop; other site
590409000112	ATP binding site [chemical binding]; other site
590409000113	Q-loop/lid; other site
590409000114	ABC transporter signature motif; other site
590409000115	Walker B; other site
590409000116	D-loop; other site
590409000117	H-loop/switch region; other site
590409000118	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
590409000119	Walker A/P-loop; other site
590409000120	ATP binding site [chemical binding]; other site
590409000121	Q-loop/lid; other site
590409000122	ABC transporter signature motif; other site
590409000123	Walker B; other site
590409000124	D-loop; other site
590409000125	H-loop/switch region; other site
590409000126	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
590409000127	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
590409000128	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
590409000129	putative PBP binding loops; other site
590409000130	dimer interface [polypeptide binding]; other site
590409000131	ABC-ATPase subunit interface; other site
590409000132	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
590409000133	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
590409000134	dimer interface [polypeptide binding]; other site
590409000135	conserved gate region; other site
590409000136	ABC-ATPase subunit interface; other site
590409000137	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
590409000138	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_15; cd08492
590409000139	Protein of unknown function (DUF1471); Region: DUF1471; pfam07338
590409000140	valine--pyruvate transaminase; Provisional; Region: avtA; PRK09440
590409000141	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
590409000142	pyridoxal 5'-phosphate binding site [chemical binding]; other site
590409000143	homodimer interface [polypeptide binding]; other site
590409000144	catalytic residue [active]
590409000145	Aldose 1-epimerase, similar to Escherichia coli c4013; Region: Aldose_epim_Ec_c4013; cd09023
590409000146	active site
590409000147	catalytic residues [active]
590409000148	bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409
590409000149	D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301
590409000150	dimerization interface [polypeptide binding]; other site
590409000151	ligand binding site [chemical binding]; other site
590409000152	NADP binding site [chemical binding]; other site
590409000153	catalytic site [active]
590409000154	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
590409000155	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
590409000156	Coenzyme A binding pocket [chemical binding]; other site
590409000157	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
590409000158	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
590409000159	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
590409000160	dimer interface [polypeptide binding]; other site
590409000161	motif 1; other site
590409000162	active site
590409000163	motif 2; other site
590409000164	motif 3; other site
590409000165	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
590409000166	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
590409000167	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
590409000168	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
590409000169	Walker A/P-loop; other site
590409000170	ATP binding site [chemical binding]; other site
590409000171	Q-loop/lid; other site
590409000172	ABC transporter signature motif; other site
590409000173	Walker B; other site
590409000174	D-loop; other site
590409000175	H-loop/switch region; other site
590409000176	TOBE domain; Region: TOBE_2; pfam08402
590409000177	MarR family; Region: MarR_2; pfam12802
590409000178	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
590409000179	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
590409000180	nucleotide binding site [chemical binding]; other site
590409000181	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
590409000182	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
590409000183	nucleotide binding site [chemical binding]; other site
590409000184	Protein of unknown function, DUF608; Region: DUF608; pfam04685
590409000185	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
590409000186	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
590409000187	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
590409000188	dimer interface [polypeptide binding]; other site
590409000189	conserved gate region; other site
590409000190	putative PBP binding loops; other site
590409000191	ABC-ATPase subunit interface; other site
590409000192	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
590409000193	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
590409000194	dimer interface [polypeptide binding]; other site
590409000195	conserved gate region; other site
590409000196	putative PBP binding loops; other site
590409000197	ABC-ATPase subunit interface; other site
590409000198	urea carboxylase; Region: urea_carbox; TIGR02712
590409000199	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
590409000200	ATP-grasp domain; Region: ATP-grasp_4; cl17255
590409000201	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785
590409000202	Allophanate hydrolase subunit 2; Region: AHS2; smart00797
590409000203	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896
590409000204	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
590409000205	carboxyltransferase (CT) interaction site; other site
590409000206	biotinylation site [posttranslational modification]; other site
590409000207	urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424
590409000208	Domain of unknown function (DUF1989); Region: DUF1989; pfam09347
590409000209	urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424
590409000210	urea carboxylase-associated protein 2; Region: urea_degr_2; TIGR03425
590409000211	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
590409000212	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
590409000213	Walker A/P-loop; other site
590409000214	ATP binding site [chemical binding]; other site
590409000215	Q-loop/lid; other site
590409000216	ABC transporter signature motif; other site
590409000217	Walker B; other site
590409000218	D-loop; other site
590409000219	H-loop/switch region; other site
590409000220	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
590409000221	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
590409000222	putative PBP binding loops; other site
590409000223	dimer interface [polypeptide binding]; other site
590409000224	ABC-ATPase subunit interface; other site
590409000225	ABC transporter periplasmic binding protein, urea carboxylase region; Region: ABC_peri_uca; TIGR03427
590409000226	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
590409000227	Protein of unknown function (DUF3053); Region: DUF3053; pfam11254
590409000228	PTS system mannitol-specific transporter subunit IICBA; Provisional; Region: PRK15083
590409000229	PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851
590409000230	PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567
590409000231	active site
590409000232	P-loop; other site
590409000233	phosphorylation site [posttranslational modification]
590409000234	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
590409000235	active site
590409000236	phosphorylation site [posttranslational modification]
590409000237	mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318
590409000238	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
590409000239	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
590409000240	Transcriptional regulator [Transcription]; Region: MtlR; COG3722
590409000241	mannitol repressor protein; Provisional; Region: mtlR; PRK11001
590409000242	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
590409000243	dimerization interface [polypeptide binding]; other site
590409000244	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
590409000245	dimer interface [polypeptide binding]; other site
590409000246	putative CheW interface [polypeptide binding]; other site
590409000247	superoxide dismutase; Provisional; Region: PRK10925
590409000248	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
590409000249	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
590409000250	formate dehydrogenase accessory protein; Reviewed; Region: PRK00724
590409000251	Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116
590409000252	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
590409000253	NAD(P) binding site [chemical binding]; other site
590409000254	catalytic residues [active]
590409000255	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
590409000256	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
590409000257	conserved cys residue [active]
590409000258	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
590409000259	Isochorismatase family; Region: Isochorismatase; pfam00857
590409000260	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220
590409000261	catalytic triad [active]
590409000262	conserved cis-peptide bond; other site
590409000263	xylulokinase; Provisional; Region: PRK15027
590409000264	Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808
590409000265	N- and C-terminal domain interface [polypeptide binding]; other site
590409000266	active site
590409000267	MgATP binding site [chemical binding]; other site
590409000268	catalytic site [active]
590409000269	metal binding site [ion binding]; metal-binding site
590409000270	xylulose binding site [chemical binding]; other site
590409000271	homodimer interface [polypeptide binding]; other site
590409000272	xylose isomerase; Provisional; Region: PRK05474
590409000273	xylose isomerase; Region: xylose_isom_A; TIGR02630
590409000274	D-xylose transporter subunit XylF; Provisional; Region: xylF; PRK10355
590409000275	Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538
590409000276	putative ligand binding site [chemical binding]; other site
590409000277	xylose transporter ATP-binding subunit; Provisional; Region: PRK13549
590409000278	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
590409000279	Walker A/P-loop; other site
590409000280	ATP binding site [chemical binding]; other site
590409000281	Q-loop/lid; other site
590409000282	ABC transporter signature motif; other site
590409000283	Walker B; other site
590409000284	D-loop; other site
590409000285	H-loop/switch region; other site
590409000286	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
590409000287	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
590409000288	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
590409000289	TM-ABC transporter signature motif; other site
590409000290	Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543
590409000291	putative dimerization interface [polypeptide binding]; other site
590409000292	Transcriptional regulators [Transcription]; Region: PurR; COG1609
590409000293	putative ligand binding site [chemical binding]; other site
590409000294	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
590409000295	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
590409000296	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
590409000297	Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135
590409000298	DJ-1 family protein; Region: not_thiJ; TIGR01383
590409000299	conserved cys residue [active]
590409000300	Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153
590409000301	putative metal binding site [ion binding]; other site
590409000302	putative homodimer interface [polypeptide binding]; other site
590409000303	putative homotetramer interface [polypeptide binding]; other site
590409000304	putative homodimer-homodimer interface [polypeptide binding]; other site
590409000305	putative allosteric switch controlling residues; other site
590409000306	nickel/cobalt efflux protein RcnA; Provisional; Region: PRK10019
590409000307	High-affinity nickel-transport protein; Region: NicO; cl00964
590409000308	argininosuccinate synthase; Validated; Region: PRK05370
590409000309	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
590409000310	MarR family; Region: MarR; pfam01047
590409000311	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
590409000312	EamA-like transporter family; Region: EamA; pfam00892
590409000313	Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227
590409000314	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
590409000315	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
590409000316	motif II; other site
590409000317	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
590409000318	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
590409000319	acyl-activating enzyme (AAE) consensus motif; other site
590409000320	AMP binding site [chemical binding]; other site
590409000321	This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142
590409000322	NADPH bind site [chemical binding]; other site
590409000323	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
590409000324	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
590409000325	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
590409000326	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
590409000327	active site
590409000328	Phosphopantetheine attachment site; Region: PP-binding; cl09936
590409000329	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
590409000330	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
590409000331	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
590409000332	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
590409000333	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
590409000334	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
590409000335	Walker A/P-loop; other site
590409000336	ATP binding site [chemical binding]; other site
590409000337	Q-loop/lid; other site
590409000338	ABC transporter signature motif; other site
590409000339	Walker B; other site
590409000340	D-loop; other site
590409000341	H-loop/switch region; other site
590409000342	Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434
590409000343	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
590409000344	FtsX-like permease family; Region: FtsX; pfam02687
590409000345	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
590409000346	FtsX-like permease family; Region: FtsX; pfam02687
590409000347	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
590409000348	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
590409000349	active site
590409000350	phosphorylation site [posttranslational modification]
590409000351	intermolecular recognition site; other site
590409000352	dimerization interface [polypeptide binding]; other site
590409000353	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
590409000354	Walker A motif; other site
590409000355	ATP binding site [chemical binding]; other site
590409000356	Walker B motif; other site
590409000357	arginine finger; other site
590409000358	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
590409000359	PAS domain; Region: PAS; smart00091
590409000360	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
590409000361	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
590409000362	ATP binding site [chemical binding]; other site
590409000363	Mg2+ binding site [ion binding]; other site
590409000364	G-X-G motif; other site
590409000365	Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091
590409000366	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
590409000367	Protein of unknown function (DUF2807); Region: DUF2807; pfam10988
590409000368	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
590409000369	active site
590409000370	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
590409000371	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
590409000372	active site
590409000373	3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal; Region: ACP_syn_III_C; pfam08541
590409000374	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
590409000375	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
590409000376	active site
590409000377	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
590409000378	active site
590409000379	D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813
590409000380	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
590409000381	acyl-activating enzyme (AAE) consensus motif; other site
590409000382	AMP binding site [chemical binding]; other site
590409000383	active site
590409000384	CoA binding site [chemical binding]; other site
590409000385	D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945
590409000386	D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813
590409000387	acyl-activating enzyme (AAE) consensus motif; other site
590409000388	AMP binding site [chemical binding]; other site
590409000389	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
590409000390	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
590409000391	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
590409000392	acyl-activating enzyme (AAE) consensus motif; other site
590409000393	acyl-activating enzyme (AAE) consensus motif; other site
590409000394	AMP binding site [chemical binding]; other site
590409000395	active site
590409000396	CoA binding site [chemical binding]; other site
590409000397	pyridoxal-dependent decarboxylase, exosortase A system-associated; Region: dCO2ase_PEP1; TIGR03099
590409000398	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Btrk Decarboxylase; Region: PLPDE_III_Btrk_like; cd06839
590409000399	dimer interface [polypeptide binding]; other site
590409000400	active site
590409000401	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
590409000402	catalytic residues [active]
590409000403	substrate binding site [chemical binding]; other site
590409000404	Autoinducer binding domain; Region: Autoind_bind; pfam03472
590409000405	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
590409000406	DNA binding residues [nucleotide binding]
590409000407	dimerization interface [polypeptide binding]; other site
590409000408	Autoinducer synthetase; Region: Autoind_synth; pfam00765
590409000409	Protein of unknown function (DUF1471); Region: DUF1471; cl11507
590409000410	hypothetical protein; Provisional; Region: PRK11820
590409000411	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
590409000412	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
590409000413	Transcriptional regulator [Transcription]; Region: LysR; COG0583
590409000414	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
590409000415	LysR substrate binding domain; Region: LysR_substrate; pfam03466
590409000416	dimerization interface [polypeptide binding]; other site
590409000417	Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355
590409000418	renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301
590409000419	active site
590409000420	dimer interface [polypeptide binding]; other site
590409000421	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
590409000422	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512
590409000423	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
590409000424	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
590409000425	putative PBP binding loops; other site
590409000426	dimer interface [polypeptide binding]; other site
590409000427	ABC-ATPase subunit interface; other site
590409000428	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
590409000429	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
590409000430	dimer interface [polypeptide binding]; other site
590409000431	conserved gate region; other site
590409000432	putative PBP binding loops; other site
590409000433	ABC-ATPase subunit interface; other site
590409000434	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
590409000435	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
590409000436	Walker A/P-loop; other site
590409000437	ATP binding site [chemical binding]; other site
590409000438	Q-loop/lid; other site
590409000439	ABC transporter signature motif; other site
590409000440	Walker B; other site
590409000441	D-loop; other site
590409000442	H-loop/switch region; other site
590409000443	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
590409000444	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
590409000445	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
590409000446	Walker A/P-loop; other site
590409000447	ATP binding site [chemical binding]; other site
590409000448	Q-loop/lid; other site
590409000449	ABC transporter signature motif; other site
590409000450	Walker B; other site
590409000451	D-loop; other site
590409000452	H-loop/switch region; other site
590409000453	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
590409000454	Beta-lactamase; Region: Beta-lactamase; pfam00144
590409000455	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
590409000456	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
590409000457	Walker A/P-loop; other site
590409000458	ATP binding site [chemical binding]; other site
590409000459	Q-loop/lid; other site
590409000460	ABC transporter signature motif; other site
590409000461	Walker B; other site
590409000462	D-loop; other site
590409000463	H-loop/switch region; other site
590409000464	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
590409000465	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
590409000466	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
590409000467	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
590409000468	HlyD family secretion protein; Region: HlyD_3; pfam13437
590409000469	Protein of unknown function (DUF2645); Region: DUF2645; pfam10840
590409000470	type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344
590409000471	L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701
590409000472	catalytic nucleophile [active]
590409000473	Peptidase M55, D-aminopeptidase dipeptide-binding protein family; Region: DAP_dppA_1; cd08663
590409000474	SxDxEG motif; other site
590409000475	active site
590409000476	metal binding site [ion binding]; metal-binding site
590409000477	homopentamer interface [polypeptide binding]; other site
590409000478	L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253
590409000479	homodimer interface [polypeptide binding]; other site
590409000480	homotetramer interface [polypeptide binding]; other site
590409000481	active site pocket [active]
590409000482	cleavage site
590409000483	glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082
590409000484	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
590409000485	dimer interface [polypeptide binding]; other site
590409000486	conserved gate region; other site
590409000487	putative PBP binding loops; other site
590409000488	ABC-ATPase subunit interface; other site
590409000489	glutathione ABC transporter permease GsiC; Provisional; Region: PRK15081
590409000490	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
590409000491	dimer interface [polypeptide binding]; other site
590409000492	conserved gate region; other site
590409000493	putative PBP binding loops; other site
590409000494	ABC-ATPase subunit interface; other site
590409000495	glutathione ABC transporter substrate-binding protein GsiB; Provisional; Region: PRK15413
590409000496	The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499
590409000497	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
590409000498	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
590409000499	Walker A/P-loop; other site
590409000500	ATP binding site [chemical binding]; other site
590409000501	Q-loop/lid; other site
590409000502	ABC transporter signature motif; other site
590409000503	Walker B; other site
590409000504	D-loop; other site
590409000505	H-loop/switch region; other site
590409000506	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
590409000507	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
590409000508	Walker A/P-loop; other site
590409000509	ATP binding site [chemical binding]; other site
590409000510	Q-loop/lid; other site
590409000511	ABC transporter signature motif; other site
590409000512	Walker B; other site
590409000513	D-loop; other site
590409000514	H-loop/switch region; other site
590409000515	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
590409000516	L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129
590409000517	L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319
590409000518	active site
590409000519	Protein of unknown function (DUF1611); Region: DUF1611; pfam07755
590409000520	P-loop ATPase protein family; Region: ATP_bind_2; cl15794
590409000521	Domain of unknown function (DUF202); Region: DUF202; pfam02656
590409000522	Domain of unknown function (DUF202); Region: DUF202; cl09954
590409000523	ribonuclease PH; Reviewed; Region: rph; PRK00173
590409000524	Ribonuclease PH; Region: RNase_PH_bact; cd11362
590409000525	hexamer interface [polypeptide binding]; other site
590409000526	active site
590409000527	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
590409000528	active site
590409000529	division inhibitor protein; Provisional; Region: slmA; PRK09480
590409000530	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
590409000531	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
590409000532	trimer interface [polypeptide binding]; other site
590409000533	active site
590409000534	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
590409000535	Flavoprotein; Region: Flavoprotein; pfam02441
590409000536	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
590409000537	Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB2; cd01048
590409000538	diiron binding motif [ion binding]; other site
590409000539	hypothetical protein; Reviewed; Region: PRK00024
590409000540	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
590409000541	MPN+ (JAMM) motif; other site
590409000542	Zinc-binding site [ion binding]; other site
590409000543	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
590409000544	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
590409000545	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
590409000546	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
590409000547	DNA binding site [nucleotide binding]
590409000548	catalytic residue [active]
590409000549	H2TH interface [polypeptide binding]; other site
590409000550	putative catalytic residues [active]
590409000551	turnover-facilitating residue; other site
590409000552	intercalation triad [nucleotide binding]; other site
590409000553	8OG recognition residue [nucleotide binding]; other site
590409000554	putative reading head residues; other site
590409000555	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
590409000556	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
590409000557	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
590409000558	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
590409000559	active site
590409000560	(T/H)XGH motif; other site
590409000561	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
590409000562	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
590409000563	putative metal binding site; other site
590409000564	3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749
590409000565	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
590409000566	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
590409000567	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
590409000568	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
590409000569	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
590409000570	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
590409000571	putative active site [active]
590409000572	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
590409000573	O-Antigen ligase; Region: Wzy_C; pfam04932
590409000574	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
590409000575	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
590409000576	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
590409000577	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
590409000578	putative active site [active]
590409000579	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
590409000580	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
590409000581	putative active site [active]
590409000582	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
590409000583	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
590409000584	putative active site [active]
590409000585	ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248
590409000586	ADP-L-glycero-D-mannoheptose-6-epimerase; Provisional; Region: rfaD; PRK11150
590409000587	NADP binding site [chemical binding]; other site
590409000588	homopentamer interface [polypeptide binding]; other site
590409000589	substrate binding site [chemical binding]; other site
590409000590	active site
590409000591	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
590409000592	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
590409000593	substrate-cofactor binding pocket; other site
590409000594	pyridoxal 5'-phosphate binding site [chemical binding]; other site
590409000595	catalytic residue [active]
590409000596	L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396
590409000597	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
590409000598	NAD(P) binding site [chemical binding]; other site
590409000599	Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936
590409000600	NodB motif; other site
590409000601	putative active site [active]
590409000602	putative catalytic site [active]
590409000603	Zn binding site [ion binding]; other site
590409000604	AmiB activator; Provisional; Region: PRK11637
590409000605	Peptidase family M23; Region: Peptidase_M23; pfam01551
590409000606	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
590409000607	active site residue [active]
590409000608	Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557
590409000609	SecA binding site; other site
590409000610	Preprotein binding site; other site
590409000611	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
590409000612	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
590409000613	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
590409000614	serine acetyltransferase; Provisional; Region: cysE; PRK11132
590409000615	Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426
590409000616	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
590409000617	trimer interface [polypeptide binding]; other site
590409000618	active site
590409000619	substrate binding site [chemical binding]; other site
590409000620	CoA binding site [chemical binding]; other site
590409000621	phospholipid:lipid A palmitoyltransferase; Provisional; Region: pagP; PRK11045
590409000622	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
590409000623	DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421
590409000624	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
590409000625	The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441
590409000626	putative dimerization interface [polypeptide binding]; other site
590409000627	5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222
590409000628	CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312
590409000629	THF binding site; other site
590409000630	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
590409000631	substrate binding site [chemical binding]; other site
590409000632	THF binding site; other site
590409000633	zinc-binding site [ion binding]; other site
590409000634	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
590409000635	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
590409000636	uridine phosphorylase; Provisional; Region: PRK11178
590409000637	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
590409000638	Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350
590409000639	Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348
590409000640	WYL domain; Region: WYL; cl14852
590409000641	phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009
590409000642	Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352
590409000643	acetylornithine deacetylase; Provisional; Region: PRK05111
590409000644	M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894
590409000645	metal binding site [ion binding]; metal-binding site
590409000646	putative dimer interface [polypeptide binding]; other site
590409000647	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
590409000648	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
590409000649	AAK_NAGK-NC: N-Acetyl-L-glutamate kinase - noncyclic (NAGK-NC) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of microbial arginine biosynthesis using the acetylated, noncyclic route of...; Region: AAK_NAGK-NC; cd04249
590409000650	nucleotide binding site [chemical binding]; other site
590409000651	N-acetyl-L-glutamate binding site [chemical binding]; other site
590409000652	argininosuccinate lyase; Provisional; Region: PRK04833
590409000653	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
590409000654	active sites [active]
590409000655	tetramer interface [polypeptide binding]; other site
590409000656	Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322
590409000657	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
590409000658	RmuC family; Region: RmuC; pfam02646
590409000659	ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209
590409000660	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
590409000661	S-adenosylmethionine binding site [chemical binding]; other site
590409000662	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165
590409000663	SCP-2 sterol transfer family; Region: SCP2; pfam02036
590409000664	putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750
590409000665	2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982
590409000666	twin arginine translocase protein A; Provisional; Region: tatA; PRK04598
590409000667	sec-independent translocase; Provisional; Region: PRK01770
590409000668	twin-arginine protein translocation system subunit TatC; Provisional; Region: PRK10921
590409000669	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
590409000670	active site
590409000671	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823
590409000672	dimer interface [polypeptide binding]; other site
590409000673	active site
590409000674	aspartate-rich active site metal binding site; other site
590409000675	allosteric magnesium binding site [ion binding]; other site
590409000676	Schiff base residues; other site
590409000677	transcriptional activator RfaH; Provisional; Region: rfaH; PRK09014
590409000678	N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; Region: NGN_SP_RfaH; cd09892
590409000679	KOW: an acronym for the authors' surnames (Kyrpides, Ouzounis and Woese); Region: KOW; cl00354
590409000680	3-octaprenyl-4-hydroxybenzoate decarboxylase; Provisional; Region: PRK10922
590409000681	FMN reductase; Validated; Region: fre; PRK08051
590409000682	NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189
590409000683	FAD binding pocket [chemical binding]; other site
590409000684	FAD binding motif [chemical binding]; other site
590409000685	phosphate binding motif [ion binding]; other site
590409000686	beta-alpha-beta structure motif; other site
590409000687	NAD binding pocket [chemical binding]; other site
590409000688	3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947
590409000689	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
590409000690	dimer interface [polypeptide binding]; other site
590409000691	active site
590409000692	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730
590409000693	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
590409000694	substrate binding site [chemical binding]; other site
590409000695	oxyanion hole (OAH) forming residues; other site
590409000696	trimer interface [polypeptide binding]; other site
590409000697	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
590409000698	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
590409000699	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
590409000700	proline dipeptidase; Provisional; Region: PRK13607
590409000701	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087
590409000702	active site
590409000703	hypothetical protein; Provisional; Region: PRK11568
590409000704	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
590409000705	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
590409000706	potassium transporter; Provisional; Region: PRK10750
590409000707	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
590409000708	protoporphyrinogen oxidase; Provisional; Region: hemG; PRK11104
590409000709	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046
590409000710	FAD binding domain; Region: FAD_binding_4; pfam01565
590409000711	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
590409000712	Biotin operon repressor [Transcription]; Region: BirA; COG1654
590409000713	bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886
590409000714	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
590409000715	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
590409000716	pantothenate kinase; Provisional; Region: PRK05439
590409000717	Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025
590409000718	ATP-binding site [chemical binding]; other site
590409000719	CoA-binding site [chemical binding]; other site
590409000720	Mg2+-binding site [ion binding]; other site
590409000721	elongation factor Tu; Reviewed; Region: PRK00049
590409000722	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
590409000723	G1 box; other site
590409000724	GEF interaction site [polypeptide binding]; other site
590409000725	GTP/Mg2+ binding site [chemical binding]; other site
590409000726	Switch I region; other site
590409000727	G2 box; other site
590409000728	G3 box; other site
590409000729	Switch II region; other site
590409000730	G4 box; other site
590409000731	G5 box; other site
590409000732	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
590409000733	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
590409000734	Antibiotic Binding Site [chemical binding]; other site
590409000735	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740
590409000736	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
590409000737	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
590409000738	putative homodimer interface [polypeptide binding]; other site
590409000739	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
590409000740	heterodimer interface [polypeptide binding]; other site
590409000741	homodimer interface [polypeptide binding]; other site
590409000742	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
590409000743	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
590409000744	23S rRNA interface [nucleotide binding]; other site
590409000745	L7/L12 interface [polypeptide binding]; other site
590409000746	putative thiostrepton binding site; other site
590409000747	L25 interface [polypeptide binding]; other site
590409000748	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
590409000749	mRNA/rRNA interface [nucleotide binding]; other site
590409000750	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
590409000751	23S rRNA interface [nucleotide binding]; other site
590409000752	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
590409000753	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
590409000754	core dimer interface [polypeptide binding]; other site
590409000755	peripheral dimer interface [polypeptide binding]; other site
590409000756	L10 interface [polypeptide binding]; other site
590409000757	L11 interface [polypeptide binding]; other site
590409000758	putative EF-Tu interaction site [polypeptide binding]; other site
590409000759	putative EF-G interaction site [polypeptide binding]; other site
590409000760	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
590409000761	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
590409000762	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
590409000763	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
590409000764	RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562
590409000765	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
590409000766	RPB3 interaction site [polypeptide binding]; other site
590409000767	RPB1 interaction site [polypeptide binding]; other site
590409000768	RPB11 interaction site [polypeptide binding]; other site
590409000769	RPB10 interaction site [polypeptide binding]; other site
590409000770	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
590409000771	DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086
590409000772	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
590409000773	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
590409000774	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
590409000775	RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998
590409000776	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
590409000777	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
590409000778	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
590409000779	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
590409000780	DNA binding site [nucleotide binding]
590409000781	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
590409000782	Protein of unknown function (DUF1176); Region: DUF1176; pfam06674
590409000783	Domain of unknown function (DUF1127); Region: DUF1127; pfam06568
590409000784	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
590409000785	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
590409000786	DNA-binding site [nucleotide binding]; DNA binding site
590409000787	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
590409000788	pyridoxal 5'-phosphate binding site [chemical binding]; other site
590409000789	homodimer interface [polypeptide binding]; other site
590409000790	catalytic residue [active]
590409000791	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
590409000792	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
590409000793	Moco binding site; other site
590409000794	metal coordination site [ion binding]; other site
590409000795	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
590409000796	heavy metal response regulator; Region: cztR_silR_copR; TIGR01387
590409000797	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
590409000798	active site
590409000799	phosphorylation site [posttranslational modification]
590409000800	intermolecular recognition site; other site
590409000801	dimerization interface [polypeptide binding]; other site
590409000802	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
590409000803	DNA binding site [nucleotide binding]
590409000804	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
590409000805	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
590409000806	dimerization interface [polypeptide binding]; other site
590409000807	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
590409000808	dimer interface [polypeptide binding]; other site
590409000809	phosphorylation site [posttranslational modification]
590409000810	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
590409000811	ATP binding site [chemical binding]; other site
590409000812	Mg2+ binding site [ion binding]; other site
590409000813	G-X-G motif; other site
590409000814	thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240
590409000815	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
590409000816	FeS/SAM binding site; other site
590409000817	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
590409000818	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
590409000819	ThiS interaction site; other site
590409000820	putative active site [active]
590409000821	tetramer interface [polypeptide binding]; other site
590409000822	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
590409000823	thiS-thiF/thiG interaction site; other site
590409000824	molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690
590409000825	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
590409000826	ATP binding site [chemical binding]; other site
590409000827	substrate interface [chemical binding]; other site
590409000828	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
590409000829	thiamine phosphate binding site [chemical binding]; other site
590409000830	active site
590409000831	pyrophosphate binding site [ion binding]; other site
590409000832	thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284
590409000833	ThiC-associated domain; Region: ThiC-associated; pfam13667
590409000834	Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422
590409000835	NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241
590409000836	NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296
590409000837	NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297
590409000838	NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429
590409000839	putative NADH binding site [chemical binding]; other site
590409000840	putative active site [active]
590409000841	nudix motif; other site
590409000842	putative metal binding site [ion binding]; other site
590409000843	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
590409000844	substrate binding site [chemical binding]; other site
590409000845	active site
590409000846	Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559
590409000847	Active_site [active]
590409000848	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3068
590409000849	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
590409000850	IHF dimer interface [polypeptide binding]; other site
590409000851	IHF - DNA interface [nucleotide binding]; other site
590409000852	Protein of unknown function (DUF1481); Region: DUF1481; pfam07356
590409000853	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
590409000854	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
590409000855	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
590409000856	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
590409000857	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
590409000858	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
590409000859	purine monophosphate binding site [chemical binding]; other site
590409000860	dimer interface [polypeptide binding]; other site
590409000861	putative catalytic residues [active]
590409000862	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
590409000863	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
590409000864	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
590409000865	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
590409000866	Walker A/P-loop; other site
590409000867	ATP binding site [chemical binding]; other site
590409000868	Q-loop/lid; other site
590409000869	ABC transporter signature motif; other site
590409000870	Walker B; other site
590409000871	D-loop; other site
590409000872	H-loop/switch region; other site
590409000873	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
590409000874	dimer interface [polypeptide binding]; other site
590409000875	conserved gate region; other site
590409000876	putative PBP binding loops; other site
590409000877	ABC-ATPase subunit interface; other site
590409000878	ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597
590409000879	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
590409000880	conserved gate region; other site
590409000881	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
590409000882	dimer interface [polypeptide binding]; other site
590409000883	conserved gate region; other site
590409000884	putative PBP binding loops; other site
590409000885	ABC-ATPase subunit interface; other site
590409000886	lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096
590409000887	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
590409000888	substrate binding pocket [chemical binding]; other site
590409000889	membrane-bound complex binding site; other site
590409000890	hinge residues; other site
590409000891	hypothetical protein; Validated; Region: PRK06186
590409000892	conserved cys residue [active]
590409000893	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
590409000894	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
590409000895	dimer interface [polypeptide binding]; other site
590409000896	conserved gate region; other site
590409000897	putative PBP binding loops; other site
590409000898	ABC-ATPase subunit interface; other site
590409000899	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
590409000900	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
590409000901	substrate binding pocket [chemical binding]; other site
590409000902	membrane-bound complex binding site; other site
590409000903	hinge residues; other site
590409000904	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
590409000905	putative catalytic site [active]
590409000906	putative phosphate binding site [ion binding]; other site
590409000907	putative metal binding site [ion binding]; other site
590409000908	DMSO reductase anchor subunit (DmsC); Region: DmsC; cl17519
590409000909	DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951
590409000910	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
590409000911	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
590409000912	Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409
590409000913	The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766
590409000914	putative [4Fe-4S] binding site [ion binding]; other site
590409000915	putative molybdopterin cofactor binding site [chemical binding]; other site
590409000916	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cd02775
590409000917	molybdopterin cofactor binding site; other site
590409000918	Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958
590409000919	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
590409000920	Factor for inversion stimulation Fis, transcriptional activator [Transcription / DNA replication, recombination, and repair]; Region: Fis; COG2901
590409000921	global DNA-binding transcriptional dual regulator Fis; Provisional; Region: fis; PRK00430
590409000922	tRNA-dihydrouridine synthase B; Provisional; Region: PRK10415
590409000923	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
590409000924	FMN binding site [chemical binding]; other site
590409000925	active site
590409000926	catalytic residues [active]
590409000927	substrate binding site [chemical binding]; other site
590409000928	Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325
590409000929	Methyltransferase domain; Region: Methyltransf_18; pfam12847
590409000930	Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327
590409000931	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
590409000932	Na binding site [ion binding]; other site
590409000933	hypothetical protein; Provisional; Region: PRK10633
590409000934	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
590409000935	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
590409000936	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
590409000937	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
590409000938	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
590409000939	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
590409000940	carboxyltransferase (CT) interaction site; other site
590409000941	biotinylation site [posttranslational modification]; other site
590409000942	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
590409000943	Dehydroquinase class II; Region: DHquinase_II; pfam01220
590409000944	active site
590409000945	trimer interface [polypeptide binding]; other site
590409000946	dimer interface [polypeptide binding]; other site
590409000947	putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419
590409000948	TMAO/DMSO reductase; Reviewed; Region: PRK05363
590409000949	YedY_like molybdopterin cofactor (Moco) binding domain, a subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. Escherichia coli YedY has been propsed to form a heterodimer, consisting of a soluble catalytic subunit termed YedY; Region: YedY_like_Moco; cd02107
590409000950	Moco binding site; other site
590409000951	metal coordination site [ion binding]; other site
590409000952	Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288
590409000953	putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823
590409000954	NADP binding site [chemical binding]; other site
590409000955	dimer interface [polypeptide binding]; other site
590409000956	regulatory protein CsrD; Provisional; Region: PRK11059
590409000957	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
590409000958	metal binding site [ion binding]; metal-binding site
590409000959	active site
590409000960	I-site; other site
590409000961	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
590409000962	rod shape-determining protein MreB; Provisional; Region: PRK13927
590409000963	MreB and similar proteins; Region: MreB_like; cd10225
590409000964	nucleotide binding site [chemical binding]; other site
590409000965	Mg binding site [ion binding]; other site
590409000966	putative protofilament interaction site [polypeptide binding]; other site
590409000967	RodZ interaction site [polypeptide binding]; other site
590409000968	rod shape-determining protein MreC; Region: mreC; TIGR00219
590409000969	rod shape-determining protein MreC; Region: MreC; pfam04085
590409000970	rod shape-determining protein MreD; Provisional; Region: PRK11060
590409000971	Maf-like protein; Region: Maf; pfam02545
590409000972	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
590409000973	active site
590409000974	dimer interface [polypeptide binding]; other site
590409000975	ribonuclease G; Provisional; Region: PRK11712
590409000976	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
590409000977	homodimer interface [polypeptide binding]; other site
590409000978	oligonucleotide binding site [chemical binding]; other site
590409000979	hypothetical protein; Provisional; Region: PRK10899
590409000980	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
590409000981	protease TldD; Provisional; Region: tldD; PRK10735
590409000982	transcriptional regulator; Provisional; Region: PRK10632
590409000983	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
590409000984	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
590409000985	putative effector binding pocket; other site
590409000986	dimerization interface [polypeptide binding]; other site
590409000987	efflux system membrane protein; Provisional; Region: PRK11594
590409000988	p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559
590409000989	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
590409000990	HlyD family secretion protein; Region: HlyD_3; pfam13437
590409000991	p-hydroxybenzoic acid efflux subunit AaeB; Provisional; Region: PRK10631
590409000992	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
590409000993	Domain of Unknown Function (DUF1543); Region: DUF1543; pfam07566
590409000994	Domain of Unknown Function (DUF1543); Region: DUF1543; pfam07566
590409000995	LysE type translocator; Region: LysE; cl00565
590409000996	hypothetical protein; Provisional; Region: PRK05255
590409000997	peptidase PmbA; Provisional; Region: PRK11040
590409000998	nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753
590409000999	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
590409001000	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
590409001001	dimerization domain swap beta strand [polypeptide binding]; other site
590409001002	regulatory protein interface [polypeptide binding]; other site
590409001003	active site
590409001004	regulatory phosphorylation site [posttranslational modification]; other site
590409001005	P-loop ATPase protein family; Region: ATP_bind_2; pfam03668
590409001006	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
590409001007	active site
590409001008	phosphorylation site [posttranslational modification]
590409001009	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
590409001010	30S subunit binding site; other site
590409001011	RNA polymerase factor sigma-54; Reviewed; Region: PRK05932
590409001012	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
590409001013	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
590409001014	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
590409001015	lipopolysaccharide ABC transporter ATP-binding protein; Provisional; Region: PRK10895
590409001016	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
590409001017	Walker A/P-loop; other site
590409001018	ATP binding site [chemical binding]; other site
590409001019	Q-loop/lid; other site
590409001020	ABC transporter signature motif; other site
590409001021	Walker B; other site
590409001022	D-loop; other site
590409001023	H-loop/switch region; other site
590409001024	lipopolysaccharide transport periplasmic protein LptA; Provisional; Region: PRK10894
590409001025	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1934
590409001026	lipopolysaccharide exporter periplasmic protein; Provisional; Region: PRK10893
590409001027	Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835
590409001028	3-deoxy-D-manno-octulosonate 8-phosphate phosphatase; Provisional; Region: PRK09484
590409001029	HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662
590409001030	D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892
590409001031	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
590409001032	putative active site [active]
590409001033	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
590409001034	putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734
590409001035	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
590409001036	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
590409001037	putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831
590409001038	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
590409001039	Walker A/P-loop; other site
590409001040	ATP binding site [chemical binding]; other site
590409001041	Q-loop/lid; other site
590409001042	ABC transporter signature motif; other site
590409001043	Walker B; other site
590409001044	D-loop; other site
590409001045	H-loop/switch region; other site
590409001046	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
590409001047	conserved hypothetical integral membrane protein; Region: TIGR00056
590409001048	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
590409001049	mce related protein; Region: MCE; pfam02470
590409001050	ABC transporter periplasmic binding protein MlaC; Provisional; Region: PRK15117
590409001051	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
590409001052	anti sigma factor interaction site; other site
590409001053	regulatory phosphorylation site [posttranslational modification]; other site
590409001054	Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007
590409001055	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
590409001056	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
590409001057	hinge; other site
590409001058	active site
590409001059	serine endoprotease; Provisional; Region: PRK10898
590409001060	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
590409001061	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
590409001062	protein binding site [polypeptide binding]; other site
590409001063	serine endoprotease; Provisional; Region: PRK10139
590409001064	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
590409001065	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
590409001066	protein binding site [polypeptide binding]; other site
590409001067	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
590409001068	hypothetical protein; Provisional; Region: PRK11677
590409001069	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3105
590409001070	Predicted ATPase [General function prediction only]; Region: COG1485
590409001071	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
590409001072	23S rRNA interface [nucleotide binding]; other site
590409001073	L3 interface [polypeptide binding]; other site
590409001074	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
590409001075	stringent starvation protein A; Provisional; Region: sspA; PRK09481
590409001076	GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059
590409001077	C-terminal domain interface [polypeptide binding]; other site
590409001078	putative GSH binding site (G-site) [chemical binding]; other site
590409001079	dimer interface [polypeptide binding]; other site
590409001080	C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186
590409001081	dimer interface [polypeptide binding]; other site
590409001082	N-terminal domain interface [polypeptide binding]; other site
590409001083	ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798
590409001084	Uncharacterized conserved protein [Function unknown]; Region: COG3791
590409001085	glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318
590409001086	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
590409001087	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
590409001088	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
590409001089	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
590409001090	active site
590409001091	dimer interface [polypeptide binding]; other site
590409001092	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
590409001093	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
590409001094	active site
590409001095	FMN binding site [chemical binding]; other site
590409001096	substrate binding site [chemical binding]; other site
590409001097	3Fe-4S cluster binding site [ion binding]; other site
590409001098	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
590409001099	domain interface; other site
590409001100	Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242
590409001101	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
590409001102	FeS/SAM binding site; other site
590409001103	aerobic respiration control sensor protein ArcB; Provisional; Region: PRK11091
590409001104	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
590409001105	putative active site [active]
590409001106	heme pocket [chemical binding]; other site
590409001107	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
590409001108	dimer interface [polypeptide binding]; other site
590409001109	phosphorylation site [posttranslational modification]
590409001110	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
590409001111	ATP binding site [chemical binding]; other site
590409001112	Mg2+ binding site [ion binding]; other site
590409001113	G-X-G motif; other site
590409001114	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
590409001115	active site
590409001116	phosphorylation site [posttranslational modification]
590409001117	intermolecular recognition site; other site
590409001118	dimerization interface [polypeptide binding]; other site
590409001119	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
590409001120	putative binding surface; other site
590409001121	active site
590409001122	isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780
590409001123	Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133
590409001124	conserved cys residue [active]
590409001125	monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056
590409001126	Transglycosylase; Region: Transgly; cl17702
590409001127	Alginate lyase; Region: Alginate_lyase; pfam05426
590409001128	outer membrane lipoprotein; Provisional; Region: PRK11023
590409001129	BON domain; Region: BON; pfam04972
590409001130	BON domain; Region: BON; pfam04972
590409001131	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
590409001132	dimer interface [polypeptide binding]; other site
590409001133	active site
590409001134	hypothetical protein; Reviewed; Region: PRK12497
590409001135	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
590409001136	Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339
590409001137	putative ligand binding site [chemical binding]; other site
590409001138	SAM-dependent 16S ribosomal RNA C1402 ribose 2'-O-methyltransferase; Provisional; Region: PRK14994
590409001139	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
590409001140	putative SAM binding site [chemical binding]; other site
590409001141	putative homodimer interface [polypeptide binding]; other site
590409001142	The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363
590409001143	Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900
590409001144	putative active site [active]
590409001145	metal binding site [ion binding]; metal-binding site
590409001146	Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754
590409001147	hypothetical protein; Provisional; Region: PRK11653
590409001148	outer membrane channel protein; Reviewed; Region: tolC; PRK09465
590409001149	ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729
590409001150	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
590409001151	dimer interface [polypeptide binding]; other site
590409001152	ADP-ribose binding site [chemical binding]; other site
590409001153	active site
590409001154	nudix motif; other site
590409001155	metal binding site [ion binding]; metal-binding site
590409001156	putative dehydrogenase; Provisional; Region: PRK11039
590409001157	Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402
590409001158	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
590409001159	active site
590409001160	metal binding site [ion binding]; metal-binding site
590409001161	hexamer interface [polypeptide binding]; other site
590409001162	esterase YqiA; Provisional; Region: PRK11071
590409001163	DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559
590409001164	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
590409001165	ATP binding site [chemical binding]; other site
590409001166	Mg2+ binding site [ion binding]; other site
590409001167	G-X-G motif; other site
590409001168	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
590409001169	anchoring element; other site
590409001170	dimer interface [polypeptide binding]; other site
590409001171	ATP binding site [chemical binding]; other site
590409001172	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
590409001173	active site
590409001174	metal binding site [ion binding]; metal-binding site
590409001175	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
590409001176	Transcriptional regulator [Transcription]; Region: LysR; COG0583
590409001177	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
590409001178	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
590409001179	dimerization interface [polypeptide binding]; other site
590409001180	Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249
590409001181	DNA topoisomerase IV subunit A; Validated; Region: PRK05561
590409001182	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
590409001183	CAP-like domain; other site
590409001184	active site
590409001185	primary dimer interface [polypeptide binding]; other site
590409001186	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
590409001187	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
590409001188	putative acyl-acceptor binding pocket; other site
590409001189	FtsI repressor; Provisional; Region: PRK10883
590409001190	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
590409001191	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
590409001192	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
590409001193	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
590409001194	active site
590409001195	catalytic tetrad [active]
590409001196	Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979
590409001197	Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187
590409001198	dimer interface [polypeptide binding]; other site
590409001199	active site
590409001200	metal binding site [ion binding]; metal-binding site
590409001201	This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146
590409001202	dimer interface [polypeptide binding]; other site
590409001203	FMN binding site [chemical binding]; other site
590409001204	NADPH bind site [chemical binding]; other site
590409001205	AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719
590409001206	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
590409001207	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
590409001208	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
590409001209	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
590409001210	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
590409001211	cystathionine beta-lyase; Provisional; Region: PRK08114
590409001212	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
590409001213	homodimer interface [polypeptide binding]; other site
590409001214	substrate-cofactor binding pocket; other site
590409001215	pyridoxal 5'-phosphate binding site [chemical binding]; other site
590409001216	catalytic residue [active]
590409001217	biopolymer transport protein ExbB; Provisional; Region: PRK10414
590409001218	Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537
590409001219	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
590409001220	D-fructose-responsive transcription factor; Region: fruct_sucro_rep; TIGR02417
590409001221	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
590409001222	DNA binding site [nucleotide binding]
590409001223	domain linker motif; other site
590409001224	Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274
590409001225	dimerization interface [polypeptide binding]; other site
590409001226	ligand binding site [chemical binding]; other site
590409001227	sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322
590409001228	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
590409001229	substrate binding [chemical binding]; other site
590409001230	active site
590409001231	Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244
590409001232	PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996
590409001233	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
590409001234	active site turn [active]
590409001235	phosphorylation site [posttranslational modification]
590409001236	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
590409001237	The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346
590409001238	trimer interface; other site
590409001239	sugar binding site [chemical binding]; other site
590409001240	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
590409001241	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
590409001242	putative substrate binding site [chemical binding]; other site
590409001243	putative ATP binding site [chemical binding]; other site
590409001244	CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641
590409001245	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
590409001246	CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587
590409001247	CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cd09729
590409001248	CRISPR/Cas system-associated protein Cse2; Region: Cse2_I-E; cl09719
590409001249	CT1975-like protein; Region: Cas_CT1975; pfam09344
590409001250	CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704
590409001251	CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cd09756
590409001252	CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cd09727
590409001253	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-E; cd09719
590409001254	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I-E; cd09648
590409001255	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
590409001256	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
590409001257	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
590409001258	dimerization interface [polypeptide binding]; other site
590409001259	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
590409001260	dimer interface [polypeptide binding]; other site
590409001261	putative CheW interface [polypeptide binding]; other site
590409001262	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254
590409001263	hypothetical protein; Provisional; Region: PRK03467
590409001264	4Fe-4S single cluster domain; Region: Fer4_12; pfam13353
590409001265	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
590409001266	FeS/SAM binding site; other site
590409001267	anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263
590409001268	ATP cone domain; Region: ATP-cone; pfam03477
590409001269	Class III ribonucleotide reductase; Region: RNR_III; cd01675
590409001270	effector binding site; other site
590409001271	active site
590409001272	Zn binding site [ion binding]; other site
590409001273	glycine loop; other site
590409001274	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105
590409001275	Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574
590409001276	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
590409001277	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503
590409001278	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
590409001279	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
590409001280	dimer interface [polypeptide binding]; other site
590409001281	conserved gate region; other site
590409001282	putative PBP binding loops; other site
590409001283	ABC-ATPase subunit interface; other site
590409001284	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
590409001285	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
590409001286	dimer interface [polypeptide binding]; other site
590409001287	conserved gate region; other site
590409001288	ABC-ATPase subunit interface; other site
590409001289	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
590409001290	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
590409001291	Walker A/P-loop; other site
590409001292	ATP binding site [chemical binding]; other site
590409001293	Q-loop/lid; other site
590409001294	ABC transporter signature motif; other site
590409001295	Walker B; other site
590409001296	D-loop; other site
590409001297	H-loop/switch region; other site
590409001298	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
590409001299	Walker A/P-loop; other site
590409001300	ATP binding site [chemical binding]; other site
590409001301	Q-loop/lid; other site
590409001302	ABC transporter signature motif; other site
590409001303	Walker B; other site
590409001304	D-loop; other site
590409001305	H-loop/switch region; other site
590409001306	Predicted proteasome-type protease [Posttranslational modification, protein turnover, chaperones]; Region: COG3484
590409001307	Bacterial proteasome, beta subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that...; Region: proteasome_beta_bacterial; cd03765
590409001308	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
590409001309	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
590409001310	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
590409001311	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307
590409001312	A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168
590409001313	Uncharacterized conserved protein [Function unknown]; Region: COG2308
590409001314	Protein of unknown function (DUF3423); Region: DUF3423; pfam11903
590409001315	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
590409001316	homotrimer interaction site [polypeptide binding]; other site
590409001317	putative active site [active]
590409001318	aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893
590409001319	Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948
590409001320	Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748
590409001321	Aspartate carbamoyltransferase, catalytic chain [Nucleotide transport and metabolism]; Region: PyrB; COG0540
590409001322	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
590409001323	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
590409001324	Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731
590409001325	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046
590409001326	beta-galactosidase; Region: BGL; TIGR03356
590409001327	ornithine carbamoyltransferase subunit I; Provisional; Region: PRK03515
590409001328	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
590409001329	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
590409001330	RNase E inhibitor protein; Provisional; Region: PRK11191
590409001331	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
590409001332	Coenzyme A binding pocket [chemical binding]; other site
590409001333	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
590409001334	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
590409001335	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
590409001336	sequence-specific DNA binding site [nucleotide binding]; other site
590409001337	salt bridge; other site
590409001338	Cupin domain; Region: Cupin_2; cl17218
590409001339	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
590409001340	Coenzyme A binding pocket [chemical binding]; other site
590409001341	hypothetical protein; Provisional; Region: PRK06489
590409001342	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
590409001343	ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144
590409001344	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
590409001345	dimerization interface [polypeptide binding]; other site
590409001346	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
590409001347	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
590409001348	dimer interface [polypeptide binding]; other site
590409001349	putative CheW interface [polypeptide binding]; other site
590409001350	arginine repressor; Provisional; Region: PRK04280
590409001351	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
590409001352	Predicted membrane protein [Function unknown]; Region: COG1288
590409001353	C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606
590409001354	ornithine carbamoyltransferase; Validated; Region: PRK02102
590409001355	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
590409001356	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
590409001357	arginine deiminase; Provisional; Region: PRK01388
590409001358	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
590409001359	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
590409001360	HIGH motif; other site
590409001361	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
590409001362	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
590409001363	active site
590409001364	KMSKS motif; other site
590409001365	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
590409001366	tRNA binding surface [nucleotide binding]; other site
590409001367	anticodon binding site; other site
590409001368	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
590409001369	DNA polymerase III subunit chi; Validated; Region: PRK05728
590409001370	multifunctional aminopeptidase A; Provisional; Region: PRK00913
590409001371	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
590409001372	interface (dimer of trimers) [polypeptide binding]; other site
590409001373	Substrate-binding/catalytic site; other site
590409001374	Zn-binding sites [ion binding]; other site
590409001375	lipopolysaccharide ABC transporter permease LptF; Provisional; Region: PRK15120
590409001376	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
590409001377	lipopolysaccharide ABC transporter permease; Provisional; Region: PRK15071
590409001378	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
590409001379	integrase; Provisional; Region: PRK09692
590409001380	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
590409001381	active site
590409001382	Int/Topo IB signature motif; other site
590409001383	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
590409001384	HsdM N-terminal domain; Region: HsdM_N; pfam12161
590409001385	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
590409001386	Methyltransferase domain; Region: Methyltransf_26; pfam13659
590409001387	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
590409001388	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
590409001389	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
590409001390	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
590409001391	Virulence protein [General function prediction only]; Region: COG3943
590409001392	Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310
590409001393	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
590409001394	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
590409001395	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
590409001396	ATP binding site [chemical binding]; other site
590409001397	putative Mg++ binding site [ion binding]; other site
590409001398	Protein of unknown function DUF45; Region: DUF45; pfam01863
590409001399	Restriction endonuclease [Defense mechanisms]; Region: Mrr; COG1715
590409001400	Mrr N-terminal domain; Region: Mrr_N; pfam14338
590409001401	Restriction endonuclease; Region: Mrr_cat; pfam04471
590409001402	Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523
590409001403	Protein of unknown function (DUF3296); Region: DUF3296; pfam11726
590409001404	Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864
590409001405	Predicted GTPase [General function prediction only]; Region: COG3596
590409001406	YfjP GTPase; Region: YfjP; cd11383
590409001407	G1 box; other site
590409001408	GTP/Mg2+ binding site [chemical binding]; other site
590409001409	Switch I region; other site
590409001410	G2 box; other site
590409001411	Switch II region; other site
590409001412	G3 box; other site
590409001413	G4 box; other site
590409001414	G5 box; other site
590409001415	Domain of unknown function (DUF932); Region: DUF932; pfam06067
590409001416	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
590409001417	MPN+ (JAMM) motif; other site
590409001418	Zinc-binding site [ion binding]; other site
590409001419	YagB/YeeU/YfjZ family; Region: YagB_YeeU_YfjZ; pfam06154
590409001420	Protein of unknown function (DUF1219); Region: DUF1219; pfam06755
590409001421	Methyltransferase domain; Region: Methyltransf_27; pfam13708
590409001422	Predicted transcriptional regulator [Transcription]; Region: COG3905
590409001423	Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016
590409001424	Cache domain; Region: Cache_1; pfam02743
590409001425	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
590409001426	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
590409001427	metal binding site [ion binding]; metal-binding site
590409001428	active site
590409001429	I-site; other site
590409001430	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
590409001431	S-adenosylmethionine binding site [chemical binding]; other site
590409001432	Pirin-related protein [General function prediction only]; Region: COG1741
590409001433	Pirin; Region: Pirin; pfam02678
590409001434	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
590409001435	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
590409001436	putative trimer interface [polypeptide binding]; other site
590409001437	putative CoA binding site [chemical binding]; other site
590409001438	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
590409001439	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
590409001440	putative DNA binding site [nucleotide binding]; other site
590409001441	putative Zn2+ binding site [ion binding]; other site
590409001442	AsnC family; Region: AsnC_trans_reg; pfam01037
590409001443	Stress responsive A/B Barrel Domain; Region: Dabb; pfam07876
590409001444	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
590409001445	PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224
590409001446	Prephenate dehydratase; Region: PDT; pfam00800
590409001447	Lysine efflux permease [General function prediction only]; Region: COG1279
590409001448	Predicted restriction endonuclease [Defense mechanisms]; Region: COG3440
590409001449	HNH endonuclease; Region: HNH_2; pfam13391
590409001450	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
590409001451	Major Facilitator Superfamily; Region: MFS_1; pfam07690
590409001452	putative substrate translocation pore; other site
590409001453	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
590409001454	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
590409001455	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
590409001456	DNA-binding site [nucleotide binding]; DNA binding site
590409001457	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
590409001458	pyridoxal 5'-phosphate binding site [chemical binding]; other site
590409001459	homodimer interface [polypeptide binding]; other site
590409001460	catalytic residue [active]
590409001461	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
590409001462	Coenzyme A binding pocket [chemical binding]; other site
590409001463	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
590409001464	Uncharacterized conserved protein [Function unknown]; Region: COG2128
590409001465	Domain of unknown function (DUF4276); Region: DUF4276; pfam14103
590409001466	Predicted ATPase [General function prediction only]; Region: COG4637
590409001467	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
590409001468	Walker A/P-loop; other site
590409001469	ATP binding site [chemical binding]; other site
590409001470	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
590409001471	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
590409001472	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
590409001473	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
590409001474	TPP-binding site [chemical binding]; other site
590409001475	dimer interface [polypeptide binding]; other site
590409001476	Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958
590409001477	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
590409001478	PYR/PP interface [polypeptide binding]; other site
590409001479	dimer interface [polypeptide binding]; other site
590409001480	TPP binding site [chemical binding]; other site
590409001481	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
590409001482	short chain dehydrogenase; Provisional; Region: PRK06841
590409001483	classical (c) SDRs; Region: SDR_c; cd05233
590409001484	NAD(P) binding site [chemical binding]; other site
590409001485	active site
590409001486	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
590409001487	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
590409001488	Predicted periplasmic lipoprotein (DUF2291); Region: DUF2291; cl02395
590409001489	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
590409001490	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
590409001491	Walker A/P-loop; other site
590409001492	ATP binding site [chemical binding]; other site
590409001493	Q-loop/lid; other site
590409001494	ABC transporter signature motif; other site
590409001495	Walker B; other site
590409001496	D-loop; other site
590409001497	H-loop/switch region; other site
590409001498	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
590409001499	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
590409001500	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
590409001501	TM-ABC transporter signature motif; other site
590409001502	Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554
590409001503	bacterial glycerol kinase 2-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_GK2_bacteria; cd07791
590409001504	N- and C-terminal domain interface [polypeptide binding]; other site
590409001505	active site
590409001506	MgATP binding site [chemical binding]; other site
590409001507	catalytic site [active]
590409001508	metal binding site [ion binding]; metal-binding site
590409001509	putative homotetramer interface [polypeptide binding]; other site
590409001510	putative homodimer interface [polypeptide binding]; other site
590409001511	glycerol binding site [chemical binding]; other site
590409001512	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
590409001513	meso-2,3-butanediol dehydrogenase-like, classical (c) SDRs; Region: meso-BDH-like_SDR_c; cd05366
590409001514	NAD binding site [chemical binding]; other site
590409001515	homotetramer interface [polypeptide binding]; other site
590409001516	homodimer interface [polypeptide binding]; other site
590409001517	active site
590409001518	substrate binding site [chemical binding]; other site
590409001519	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
590409001520	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_10; cd08515
590409001521	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
590409001522	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
590409001523	dimer interface [polypeptide binding]; other site
590409001524	conserved gate region; other site
590409001525	putative PBP binding loops; other site
590409001526	ABC-ATPase subunit interface; other site
590409001527	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
590409001528	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
590409001529	dimer interface [polypeptide binding]; other site
590409001530	conserved gate region; other site
590409001531	putative PBP binding loops; other site
590409001532	ABC-ATPase subunit interface; other site
590409001533	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
590409001534	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
590409001535	Walker A/P-loop; other site
590409001536	ATP binding site [chemical binding]; other site
590409001537	Q-loop/lid; other site
590409001538	ABC transporter signature motif; other site
590409001539	Walker B; other site
590409001540	D-loop; other site
590409001541	H-loop/switch region; other site
590409001542	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
590409001543	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
590409001544	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
590409001545	Walker A/P-loop; other site
590409001546	ATP binding site [chemical binding]; other site
590409001547	Q-loop/lid; other site
590409001548	ABC transporter signature motif; other site
590409001549	Walker B; other site
590409001550	D-loop; other site
590409001551	H-loop/switch region; other site
590409001552	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
590409001553	hypothetical protein; Provisional; Region: PRK07079
590409001554	Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_2; cd05679
590409001555	metal binding site [ion binding]; metal-binding site
590409001556	putative dimer interface [polypeptide binding]; other site
590409001557	Transcriptional regulator [Transcription]; Region: LysR; COG0583
590409001558	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
590409001559	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
590409001560	dimerization interface [polypeptide binding]; other site
590409001561	1-aminocyclopropane-1-carboxylate deaminase [Amino acid transport and metabolism]; Region: Acd; COG2515
590409001562	Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449
590409001563	pyridoxal 5'-phosphate binding site [chemical binding]; other site
590409001564	catalytic residue [active]
590409001565	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
590409001566	active site
590409001567	leucine-responsive transcriptional regulator; Provisional; Region: PRK11169
590409001568	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
590409001569	putative DNA binding site [nucleotide binding]; other site
590409001570	putative Zn2+ binding site [ion binding]; other site
590409001571	AsnC family; Region: AsnC_trans_reg; pfam01037
590409001572	chorismate mutase; Provisional; Region: PRK08055
590409001573	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
590409001574	putative substrate translocation pore; other site
590409001575	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
590409001576	Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418
590409001577	Zn2+ binding site [ion binding]; other site
590409001578	Mg2+ binding site [ion binding]; other site
590409001579	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
590409001580	Transcriptional regulator [Transcription]; Region: IclR; COG1414
590409001581	Bacterial transcriptional regulator; Region: IclR; pfam01614
590409001582	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
590409001583	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
590409001584	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
590409001585	dimer interface [polypeptide binding]; other site
590409001586	putative CheW interface [polypeptide binding]; other site
590409001587	L-rhamnose 1-epimerase; Region: YiiL_rotase; TIGR02625
590409001588	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398
590409001589	intersubunit interface [polypeptide binding]; other site
590409001590	active site
590409001591	Zn2+ binding site [ion binding]; other site
590409001592	L-rhamnose isomerase; Provisional; Region: PRK01076
590409001593	Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900
590409001594	L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771
590409001595	N- and C-terminal domain interface [polypeptide binding]; other site
590409001596	active site
590409001597	putative catalytic site [active]
590409001598	metal binding site [ion binding]; metal-binding site
590409001599	ATP binding site [chemical binding]; other site
590409001600	rhamnulokinase; Provisional; Region: rhaB; PRK10640
590409001601	carbohydrate binding site [chemical binding]; other site
590409001602	transcriptional activator RhaS; Provisional; Region: PRK13503
590409001603	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
590409001604	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
590409001605	transcriptional activator RhaR; Provisional; Region: PRK13501
590409001606	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
590409001607	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
590409001608	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
590409001609	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
590409001610	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
590409001611	Walker A/P-loop; other site
590409001612	ATP binding site [chemical binding]; other site
590409001613	Q-loop/lid; other site
590409001614	ABC transporter signature motif; other site
590409001615	Walker B; other site
590409001616	D-loop; other site
590409001617	H-loop/switch region; other site
590409001618	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
590409001619	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
590409001620	Walker A/P-loop; other site
590409001621	ATP binding site [chemical binding]; other site
590409001622	Q-loop/lid; other site
590409001623	ABC transporter signature motif; other site
590409001624	Walker B; other site
590409001625	D-loop; other site
590409001626	H-loop/switch region; other site
590409001627	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
590409001628	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
590409001629	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
590409001630	dimer interface [polypeptide binding]; other site
590409001631	conserved gate region; other site
590409001632	putative PBP binding loops; other site
590409001633	ABC-ATPase subunit interface; other site
590409001634	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
590409001635	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
590409001636	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
590409001637	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_15; cd08492
590409001638	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393
590409001639	Chitin synthase; Region: Chitin_synth_1; pfam01644
590409001640	Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215
590409001641	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
590409001642	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4102
590409001643	Protein of unknown function (DUF1800); Region: DUF1800; pfam08811
590409001644	Protein of unknown function (DUF1440); Region: DUF1440; pfam07274
590409001645	oxidoreductase; Provisional; Region: PRK08013
590409001646	Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988
590409001647	2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK05732
590409001648	2-polyprenyl-6-methoxyphenol 4-hydroxylase; Region: UbiH; TIGR01984
590409001649	proline aminopeptidase P II; Provisional; Region: PRK10879
590409001650	Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195
590409001651	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087
590409001652	active site
590409001653	hypothetical protein; Reviewed; Region: PRK01736
590409001654	Z-ring-associated protein; Provisional; Region: PRK10972
590409001655	5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360
590409001656	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
590409001657	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
590409001658	non-specific DNA binding site [nucleotide binding]; other site
590409001659	salt bridge; other site
590409001660	bifunctional DNA-binding transcriptional repressor/ NMN adenylyltransferase; Provisional; Region: PRK08099
590409001661	sequence-specific DNA binding site [nucleotide binding]; other site
590409001662	Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional NadR-like proteins; Region: NMNAT_NadR; cd02167
590409001663	active site
590409001664	(T/H)XGH motif; other site
590409001665	Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172
590409001666	DNA repair protein RadA; Provisional; Region: PRK11823
590409001667	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
590409001668	Walker A motif/ATP binding site; other site
590409001669	ATP binding site [chemical binding]; other site
590409001670	Walker B motif; other site
590409001671	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
590409001672	phosphoserine phosphatase; Provisional; Region: serB; PRK11133
590409001673	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
590409001674	motif I; other site
590409001675	motif II; other site
590409001676	hypothetical protein; Provisional; Region: PRK11246
590409001677	Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106
590409001678	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
590409001679	S-adenosylmethionine binding site [chemical binding]; other site
590409001680	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
590409001681	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
590409001682	G1 box; other site
590409001683	putative GEF interaction site [polypeptide binding]; other site
590409001684	GTP/Mg2+ binding site [chemical binding]; other site
590409001685	Switch I region; other site
590409001686	G2 box; other site
590409001687	G3 box; other site
590409001688	Switch II region; other site
590409001689	G4 box; other site
590409001690	G5 box; other site
590409001691	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
590409001692	periplasmic protein; Provisional; Region: PRK10568
590409001693	BON domain; Region: BON; pfam04972
590409001694	BON domain; Region: BON; pfam04972
590409001695	CsbD-like; Region: CsbD; cl17424
590409001696	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
590409001697	active site
590409001698	Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977
590409001699	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
590409001700	Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967
590409001701	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
590409001702	NAD(P) binding site [chemical binding]; other site
590409001703	active site
590409001704	ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181
590409001705	dimer interface [polypeptide binding]; other site
590409001706	ligand binding site [chemical binding]; other site
590409001707	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
590409001708	dimerization interface [polypeptide binding]; other site
590409001709	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
590409001710	dimer interface [polypeptide binding]; other site
590409001711	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
590409001712	putative CheW interface [polypeptide binding]; other site
590409001713	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
590409001714	HD domain; Region: HD_4; pfam13328
590409001715	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
590409001716	Coenzyme A binding pocket [chemical binding]; other site
590409001717	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
590409001718	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
590409001719	Walker A/P-loop; other site
590409001720	ATP binding site [chemical binding]; other site
590409001721	Q-loop/lid; other site
590409001722	ABC transporter signature motif; other site
590409001723	Walker B; other site
590409001724	D-loop; other site
590409001725	H-loop/switch region; other site
590409001726	Metal binding protein TroA_a.  These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148
590409001727	proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868
590409001728	putative ligand binding residues [chemical binding]; other site
590409001729	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
590409001730	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
590409001731	ABC-ATPase subunit  interface; other site
590409001732	dimer interface [polypeptide binding]; other site
590409001733	putative PBP binding regions; other site
590409001734	alkyl hydroperoxide reductase subunit C; Provisional; Region: PRK10382
590409001735	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
590409001736	dimer interface [polypeptide binding]; other site
590409001737	decamer (pentamer of dimers) interface [polypeptide binding]; other site
590409001738	catalytic triad [active]
590409001739	peroxidatic and resolving cysteines [active]
590409001740	alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317
590409001741	Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974
590409001742	catalytic residue [active]
590409001743	TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026
590409001744	catalytic residues [active]
590409001745	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
590409001746	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
590409001747	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5255
590409001748	Domain of unknown function (DUF1868); Region: 2H-phosphodiest; pfam08975
590409001749	phosphonate metabolim protein, transferase hexapeptide repeat family; Region: phn_thr-fam; TIGR03308
590409001750	Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349
590409001751	trimer interface [polypeptide binding]; other site
590409001752	active site
590409001753	substrate binding site [chemical binding]; other site
590409001754	CoA binding site [chemical binding]; other site
590409001755	OHCU decarboxylase; Region: UraD_2; TIGR03180
590409001756	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
590409001757	Heavy-metal-associated domain; Region: HMA; pfam00403
590409001758	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
590409001759	Soluble P-type ATPase [General function prediction only]; Region: COG4087
590409001760	Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047
590409001761	Helix-Turn-Helix DNA binding domain of the CadR and PbrR transcription regulators; Region: HTH_CadR-PbrR; cd04784
590409001762	DNA binding residues [nucleotide binding]
590409001763	dimer interface [polypeptide binding]; other site
590409001764	putative metal binding site [ion binding]; other site
590409001765	Transcriptional regulators [Transcription]; Region: PurR; COG1609
590409001766	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
590409001767	DNA binding site [nucleotide binding]
590409001768	domain linker motif; other site
590409001769	Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575
590409001770	putative dimerization interface [polypeptide binding]; other site
590409001771	putative ligand binding site [chemical binding]; other site
590409001772	Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316
590409001773	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
590409001774	active site pocket [active]
590409001775	Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023
590409001776	Bacterial sugar transferase; Region: Bac_transf; pfam02397
590409001777	Uncharacterized protein conserved in bacteria (DUF2320); Region: DUF2320; pfam10082
590409001778	putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027
590409001779	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
590409001780	SLBB domain; Region: SLBB; pfam10531
590409001781	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
590409001782	Chain length determinant protein; Region: Wzz; pfam02706
590409001783	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
590409001784	Polysaccharide biosynthesis protein; Region: Polysacc_synt_3; pfam13440
590409001785	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
590409001786	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
590409001787	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
590409001788	active site
590409001789	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
590409001790	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
590409001791	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
590409001792	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
590409001793	putative acyl transferase; Provisional; Region: PRK10191
590409001794	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
590409001795	trimer interface [polypeptide binding]; other site
590409001796	active site
590409001797	substrate binding site [chemical binding]; other site
590409001798	CoA binding site [chemical binding]; other site
590409001799	37-kD nucleoid-associated bacterial protein; Region: NA37; pfam04245
590409001800	putative transcriptional regulator; Provisional; Region: PRK11640
590409001801	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
590409001802	thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293
590409001803	Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412
590409001804	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
590409001805	DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953
590409001806	DsbD alpha interface [polypeptide binding]; other site
590409001807	catalytic residues [active]
590409001808	divalent-cation tolerance protein CutA; Provisional; Region: PRK10645
590409001809	anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412
590409001810	Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704
590409001811	aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273
590409001812	Aspartase; Region: Aspartase; cd01357
590409001813	active sites [active]
590409001814	tetramer interface [polypeptide binding]; other site
590409001815	Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030
590409001816	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
590409001817	oligomerisation interface [polypeptide binding]; other site
590409001818	mobile loop; other site
590409001819	roof hairpin; other site
590409001820	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
590409001821	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
590409001822	ring oligomerisation interface [polypeptide binding]; other site
590409001823	ATP/Mg binding site [chemical binding]; other site
590409001824	stacking interactions; other site
590409001825	hinge regions; other site
590409001826	chorismate pyruvate lyase; Provisional; Region: ubiC; PRK11655
590409001827	4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848
590409001828	UbiA prenyltransferase family; Region: UbiA; pfam01040
590409001829	glycerol-3-phosphate O-acyltransferase; Region: plsB; TIGR03703
590409001830	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993
590409001831	putative acyl-acceptor binding pocket; other site
590409001832	Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818
590409001833	LexA repressor; Validated; Region: PRK00215
590409001834	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
590409001835	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
590409001836	Catalytic site [active]
590409001837	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
590409001838	metal binding site 2 [ion binding]; metal-binding site
590409001839	putative DNA binding helix; other site
590409001840	metal binding site 1 [ion binding]; metal-binding site
590409001841	dimer interface [polypeptide binding]; other site
590409001842	structural Zn2+ binding site [ion binding]; other site
590409001843	Pirin-related protein [General function prediction only]; Region: COG1741
590409001844	Pirin; Region: Pirin; pfam02678
590409001845	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
590409001846	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074
590409001847	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
590409001848	dimerization interface [polypeptide binding]; other site
590409001849	Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435
590409001850	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
590409001851	Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409
590409001852	C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190
590409001853	putative dimer interface [polypeptide binding]; other site
590409001854	N-terminal domain interface [polypeptide binding]; other site
590409001855	putative substrate binding pocket (H-site) [chemical binding]; other site
590409001856	Predicted membrane protein [Function unknown]; Region: COG2259
590409001857	YqjK-like protein; Region: YqjK; pfam13997
590409001858	Predicted membrane protein [Function unknown]; Region: COG5393
590409001859	Uncharacterized conserved protein [Function unknown]; Region: ElaB; COG4575
590409001860	EnvZ/OmpR regulon moderator; Provisional; Region: PRK10629
590409001861	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
590409001862	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
590409001863	DNA-binding transcriptional repressor ExuR; Provisional; Region: PRK11523
590409001864	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
590409001865	DNA-binding site [nucleotide binding]; DNA binding site
590409001866	FCD domain; Region: FCD; pfam07729
590409001867	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
590409001868	D-galactonate transporter; Region: 2A0114; TIGR00893
590409001869	putative substrate translocation pore; other site
590409001870	Glucuronate isomerase; Region: UxaC; pfam02614
590409001871	Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904
590409001872	altronate oxidoreductase; Provisional; Region: PRK03643
590409001873	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
590409001874	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
590409001875	Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613
590409001876	galactarate dehydratase; Region: galactar-dH20; TIGR03248
590409001877	D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295
590409001878	Bacterial inner membrane protein; Region: Imp-YgjV; pfam10688
590409001879	integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718
590409001880	SAM-dependent 23S ribosomal RNA mG1835 methyltransferase; Provisional; Region: PRK15001
590409001881	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
590409001882	S-adenosylmethionine binding site [chemical binding]; other site
590409001883	DNA-binding transcriptional activator UhpA; Provisional; Region: PRK10360
590409001884	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
590409001885	active site
590409001886	phosphorylation site [posttranslational modification]
590409001887	intermolecular recognition site; other site
590409001888	dimerization interface [polypeptide binding]; other site
590409001889	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
590409001890	DNA binding residues [nucleotide binding]
590409001891	dimerization interface [polypeptide binding]; other site
590409001892	sensory histidine kinase UhpB; Provisional; Region: PRK11644
590409001893	MASE1; Region: MASE1; cl17823
590409001894	Histidine kinase; Region: HisKA_3; pfam07730
590409001895	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
590409001896	ATP binding site [chemical binding]; other site
590409001897	Mg2+ binding site [ion binding]; other site
590409001898	G-X-G motif; other site
590409001899	regulatory protein UhpC; Provisional; Region: PRK11663
590409001900	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
590409001901	putative substrate translocation pore; other site
590409001902	sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556
590409001903	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
590409001904	putative substrate translocation pore; other site
590409001905	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916
590409001906	dimer interface [polypeptide binding]; other site
590409001907	thiamine biosynthesis lipoprotein ApbE; Provisional; Region: PRK10461
590409001908	ApbE family; Region: ApbE; pfam02424
590409001909	2-isopropylmalate synthase; Validated; Region: PRK03739
590409001910	Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942
590409001911	active site
590409001912	catalytic residues [active]
590409001913	metal binding site [ion binding]; metal-binding site
590409001914	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
590409001915	Cupin domain; Region: Cupin_2; cl17218
590409001916	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
590409001917	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
590409001918	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
590409001919	Old yellow enzyme (OYE)-related FMN binding domain, group 4.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735
590409001920	putative active site [active]
590409001921	putative FMN binding site [chemical binding]; other site
590409001922	putative substrate binding site [chemical binding]; other site
590409001923	putative catalytic residue [active]
590409001924	FMN-binding domain; Region: FMN_bind; cl01081
590409001925	fumarate reductase flavoprotein subunit; Validated; Region: PRK06481
590409001926	L-aspartate oxidase; Provisional; Region: PRK06175
590409001927	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
590409001928	ApbE family; Region: ApbE; pfam02424
590409001929	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
590409001930	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
590409001931	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
590409001932	active site
590409001933	catalytic tetrad [active]
590409001934	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
590409001935	classical (c) SDRs; Region: SDR_c; cd05233
590409001936	NAD(P) binding site [chemical binding]; other site
590409001937	active site
590409001938	RNA polymerase sigma factor RpoD; Validated; Region: PRK05658
590409001939	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
590409001940	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
590409001941	Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546
590409001942	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
590409001943	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
590409001944	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
590409001945	DNA binding residues [nucleotide binding]
590409001946	DNA primase; Validated; Region: dnaG; PRK05667
590409001947	CHC2 zinc finger; Region: zf-CHC2; pfam01807
590409001948	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
590409001949	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
590409001950	active site
590409001951	metal binding site [ion binding]; metal-binding site
590409001952	interdomain interaction site; other site
590409001953	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
590409001954	DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278
590409001955	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
590409001956	UGMP family protein; Validated; Region: PRK09604
590409001957	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884
590409001958	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
590409001959	arginine repressor; Provisional; Region: PRK05066
590409001960	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
590409001961	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
590409001962	malate dehydrogenase; Provisional; Region: PRK05086
590409001963	Glyoxysomal and mitochondrial malate dehydrogenases; Region: MDH_glyoxysomal_mitochondrial; cd01337
590409001964	NAD binding site [chemical binding]; other site
590409001965	dimerization interface [polypeptide binding]; other site
590409001966	Substrate binding site [chemical binding]; other site
590409001967	Winged helix-turn-helix DNA-binding; Region: HTH_35; pfam13693
590409001968	Putative transcription regulator (DUF1323); Region: DUF1323; pfam07037
590409001969	Mu DNA-binding domain; Region: HTH_Tnp_Mu_1; pfam02316
590409001970	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
590409001971	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
590409001972	substrate binding pocket [chemical binding]; other site
590409001973	chain length determination region; other site
590409001974	substrate-Mg2+ binding site; other site
590409001975	catalytic residues [active]
590409001976	aspartate-rich region 1; other site
590409001977	active site lid residues [active]
590409001978	aspartate-rich region 2; other site
590409001979	50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278
590409001980	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
590409001981	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
590409001982	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
590409001983	EamA-like transporter family; Region: EamA; pfam00892
590409001984	GTPase CgtA; Reviewed; Region: obgE; PRK12298
590409001985	GTP1/OBG; Region: GTP1_OBG; pfam01018
590409001986	Obg GTPase; Region: Obg; cd01898
590409001987	G1 box; other site
590409001988	GTP/Mg2+ binding site [chemical binding]; other site
590409001989	Switch I region; other site
590409001990	G2 box; other site
590409001991	G3 box; other site
590409001992	Switch II region; other site
590409001993	G4 box; other site
590409001994	G5 box; other site
590409001995	D-alanyl-D-alanine carboxypeptidase/endopeptidase; Provisional; Region: PRK11113
590409001996	D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666
590409001997	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
590409001998	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
590409001999	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
590409002000	RNA-binding protein YhbY; Provisional; Region: PRK10343
590409002001	23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293
590409002002	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
590409002003	S-adenosylmethionine binding site [chemical binding]; other site
590409002004	ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733
590409002005	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
590409002006	Walker A motif; other site
590409002007	ATP binding site [chemical binding]; other site
590409002008	Walker B motif; other site
590409002009	arginine finger; other site
590409002010	Peptidase family M41; Region: Peptidase_M41; pfam01434
590409002011	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
590409002012	dihydropteroate synthase; Region: DHPS; TIGR01496
590409002013	substrate binding pocket [chemical binding]; other site
590409002014	dimer interface [polypeptide binding]; other site
590409002015	inhibitor binding site; inhibition site
590409002016	phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887
590409002017	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
590409002018	active site
590409002019	substrate binding site [chemical binding]; other site
590409002020	metal binding site [ion binding]; metal-binding site
590409002021	Preprotein translocase SecG subunit; Region: SecG; pfam03840
590409002022	ribosome maturation protein RimP; Reviewed; Region: PRK00092
590409002023	Sm and related proteins; Region: Sm_like; cl00259
590409002024	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
590409002025	putative oligomer interface [polypeptide binding]; other site
590409002026	putative RNA binding site [nucleotide binding]; other site
590409002027	transcription elongation factor NusA; Validated; Region: nusA; PRK09202
590409002028	NusA N-terminal domain; Region: NusA_N; pfam08529
590409002029	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
590409002030	RNA binding site [nucleotide binding]; other site
590409002031	homodimer interface [polypeptide binding]; other site
590409002032	NusA-like KH domain; Region: KH_5; pfam13184
590409002033	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
590409002034	G-X-X-G motif; other site
590409002035	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
590409002036	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
590409002037	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
590409002038	Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364
590409002039	translation initiation factor IF-2; Region: IF-2; TIGR00487
590409002040	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
590409002041	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
590409002042	G1 box; other site
590409002043	putative GEF interaction site [polypeptide binding]; other site
590409002044	GTP/Mg2+ binding site [chemical binding]; other site
590409002045	Switch I region; other site
590409002046	G2 box; other site
590409002047	G3 box; other site
590409002048	Switch II region; other site
590409002049	G4 box; other site
590409002050	G5 box; other site
590409002051	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
590409002052	Translation-initiation factor 2; Region: IF-2; pfam11987
590409002053	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
590409002054	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
590409002055	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033
590409002056	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
590409002057	RNA binding site [nucleotide binding]; other site
590409002058	active site
590409002059	Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157
590409002060	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
590409002061	16S/18S rRNA binding site [nucleotide binding]; other site
590409002062	S13e-L30e interaction site [polypeptide binding]; other site
590409002063	25S rRNA binding site [nucleotide binding]; other site
590409002064	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
590409002065	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
590409002066	RNase E interface [polypeptide binding]; other site
590409002067	trimer interface [polypeptide binding]; other site
590409002068	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
590409002069	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
590409002070	RNase E interface [polypeptide binding]; other site
590409002071	trimer interface [polypeptide binding]; other site
590409002072	active site
590409002073	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
590409002074	putative nucleic acid binding region [nucleotide binding]; other site
590409002075	G-X-X-G motif; other site
590409002076	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
590409002077	RNA binding site [nucleotide binding]; other site
590409002078	domain interface; other site
590409002079	lipoprotein NlpI; Provisional; Region: PRK11189
590409002080	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
590409002081	binding surface
590409002082	TPR motif; other site
590409002083	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
590409002084	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
590409002085	ATP binding site [chemical binding]; other site
590409002086	Mg++ binding site [ion binding]; other site
590409002087	motif III; other site
590409002088	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
590409002089	nucleotide binding region [chemical binding]; other site
590409002090	ATP-binding site [chemical binding]; other site
590409002091	RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499
590409002092	putative RNA binding site [nucleotide binding]; other site
590409002093	hypothetical protein; Provisional; Region: PRK10508
590409002094	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
590409002095	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347
590409002096	putative protease; Provisional; Region: PRK15447
590409002097	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
590409002098	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
590409002099	Peptidase family U32; Region: Peptidase_U32; pfam01136
590409002100	Putative lipid carrier protein [Lipid metabolism]; Region: COG3154
590409002101	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
590409002102	Coenzyme A binding pocket [chemical binding]; other site
590409002103	The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456
590409002104	GIY-YIG motif/motif A; other site
590409002105	putative active site [active]
590409002106	putative metal binding site [ion binding]; other site
590409002107	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
590409002108	intersubunit interface [polypeptide binding]; other site
590409002109	active site
590409002110	catalytic residue [active]
590409002111	thymidine phosphorylase; Reviewed; Region: deoA; PRK05820
590409002112	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
590409002113	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
590409002114	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941
590409002115	phosphopentomutase; Provisional; Region: PRK05362
590409002116	Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676
590409002117	purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819
590409002118	Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820
590409002119	ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491
590409002120	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
590409002121	Coenzyme A binding pocket [chemical binding]; other site
590409002122	DNA polymerase III subunit psi; Validated; Region: PRK06856
590409002123	16S ribosomal RNA m2G1207 methyltransferase; Provisional; Region: rsmC; PRK09489
590409002124	Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468
590409002125	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
590409002126	S-adenosylmethionine binding site [chemical binding]; other site
590409002127	Transcriptional regulator [Transcription]; Region: LysR; COG0583
590409002128	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
590409002129	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472
590409002130	putative effector binding pocket; other site
590409002131	putative dimerization interface [polypeptide binding]; other site
590409002132	Protein of unknown function (DUF1435); Region: DUF1435; pfam07256
590409002133	Transcriptional regulator [Transcription]; Region: LysR; COG0583
590409002134	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
590409002135	The C-terminal substrate binding domain of LysR-type transcrptional regulator BudR, which is responsible for activation of the expression of the butanediol operon genes; contains the type 2 periplasmic binding fold; Region: PBP2_BudR; cd08451
590409002136	putative dimerization interface [polypeptide binding]; other site
590409002137	putative substrate binding pocket [chemical binding]; other site
590409002138	Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306
590409002139	acetolactate synthase; Reviewed; Region: PRK08617
590409002140	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
590409002141	PYR/PP interface [polypeptide binding]; other site
590409002142	dimer interface [polypeptide binding]; other site
590409002143	TPP binding site [chemical binding]; other site
590409002144	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
590409002145	Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010
590409002146	TPP-binding site [chemical binding]; other site
590409002147	dimer interface [polypeptide binding]; other site
590409002148	L-1,2-propanediol oxidoreductase; Provisional; Region: PRK10624
590409002149	Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176
590409002150	dimer interface [polypeptide binding]; other site
590409002151	active site
590409002152	metal binding site [ion binding]; metal-binding site
590409002153	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
590409002154	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
590409002155	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
590409002156	lipoyl attachment site [posttranslational modification]; other site
590409002157	glycine dehydrogenase; Provisional; Region: PRK05367
590409002158	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
590409002159	tetramer interface [polypeptide binding]; other site
590409002160	pyridoxal 5'-phosphate binding site [chemical binding]; other site
590409002161	catalytic residue [active]
590409002162	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
590409002163	tetramer interface [polypeptide binding]; other site
590409002164	pyridoxal 5'-phosphate binding site [chemical binding]; other site
590409002165	catalytic residue [active]
590409002166	HD domain; Region: HD_3; pfam13023
590409002167	hemolysin; Provisional; Region: PRK15087
590409002168	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
590409002169	putative global regulator; Reviewed; Region: PRK09559
590409002170	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
590409002171	hypothetical protein; Provisional; Region: PRK10878
590409002172	Protein of unknown function (DUF1434); Region: DUF1434; pfam07254
590409002173	flavodoxin FldB; Provisional; Region: PRK12359
590409002174	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
590409002175	metabolite-proton symporter; Region: 2A0106; TIGR00883
590409002176	putative substrate translocation pore; other site
590409002177	site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283
590409002178	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
590409002179	active site
590409002180	Int/Topo IB signature motif; other site
590409002181	protein disulfide isomerase II DsbC; Provisional; Region: PRK10877
590409002182	DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020
590409002183	dimerization domain [polypeptide binding]; other site
590409002184	dimer interface [polypeptide binding]; other site
590409002185	catalytic residues [active]
590409002186	ssDNA exonuclease RecJ; Provisional; Region: PRK11070
590409002187	DHH family; Region: DHH; pfam01368
590409002188	DHHA1 domain; Region: DHHA1; pfam02272
590409002189	peptide chain release factor 2; Validated; Region: prfB; PRK00578
590409002190	This domain is found in peptide chain release factors; Region: PCRF; smart00937
590409002191	RF-1 domain; Region: RF-1; pfam00472
590409002192	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
590409002193	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
590409002194	dimer interface [polypeptide binding]; other site
590409002195	putative anticodon binding site; other site
590409002196	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
590409002197	motif 1; other site
590409002198	active site
590409002199	motif 2; other site
590409002200	motif 3; other site
590409002201	LysE type translocator; Region: LysE; cl00565
590409002202	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
590409002203	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
590409002204	dimer interface [polypeptide binding]; other site
590409002205	phosphorylation site [posttranslational modification]
590409002206	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
590409002207	ATP binding site [chemical binding]; other site
590409002208	Mg2+ binding site [ion binding]; other site
590409002209	G-X-G motif; other site
590409002210	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
590409002211	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
590409002212	active site
590409002213	phosphorylation site [posttranslational modification]
590409002214	intermolecular recognition site; other site
590409002215	dimerization interface [polypeptide binding]; other site
590409002216	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
590409002217	DNA binding site [nucleotide binding]
590409002218	Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033
590409002219	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
590409002220	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
590409002221	Moco binding site; other site
590409002222	metal coordination site [ion binding]; other site
590409002223	Predicted transcriptional regulators [Transcription]; Region: COG1733
590409002224	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
590409002225	dTDP-glucose 4,6 dehydratase; Provisional; Region: PRK10084
590409002226	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
590409002227	NAD binding site [chemical binding]; other site
590409002228	substrate binding site [chemical binding]; other site
590409002229	homodimer interface [polypeptide binding]; other site
590409002230	active site
590409002231	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
590409002232	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
590409002233	substrate binding site; other site
590409002234	tetramer interface; other site
590409002235	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405
590409002236	mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479
590409002237	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
590409002238	Substrate binding site; other site
590409002239	Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050
590409002240	phosphomannomutase CpsG; Provisional; Region: PRK15414
590409002241	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
590409002242	active site
590409002243	substrate binding site [chemical binding]; other site
590409002244	metal binding site [ion binding]; metal-binding site
590409002245	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
590409002246	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
590409002247	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
590409002248	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
590409002249	Walker A/P-loop; other site
590409002250	ATP binding site [chemical binding]; other site
590409002251	Q-loop/lid; other site
590409002252	ABC transporter signature motif; other site
590409002253	Walker B; other site
590409002254	D-loop; other site
590409002255	H-loop/switch region; other site
590409002256	Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541
590409002257	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
590409002258	acyl-activating enzyme (AAE) consensus motif; other site
590409002259	active site
590409002260	AMP binding site [chemical binding]; other site
590409002261	CoA binding site [chemical binding]; other site
590409002262	Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u6; cd10930
590409002263	NodB motif; other site
590409002264	putative active site [active]
590409002265	putative catalytic site [active]
590409002266	UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236
590409002267	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
590409002268	active site
590409002269	homodimer interface [polypeptide binding]; other site
590409002270	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950
590409002271	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
590409002272	putative homodimer interface [polypeptide binding]; other site
590409002273	Radical SAM superfamily; Region: Radical_SAM; pfam04055
590409002274	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
590409002275	FeS/SAM binding site; other site
590409002276	Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692
590409002277	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
590409002278	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
590409002279	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
590409002280	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
590409002281	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
590409002282	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
590409002283	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
590409002284	catalytic core [active]
590409002285	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
590409002286	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
590409002287	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
590409002288	Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439
590409002289	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
590409002290	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
590409002291	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_4; cd03795
590409002292	putative ADP-binding pocket [chemical binding]; other site
590409002293	Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086
590409002294	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
590409002295	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
590409002296	NAD(P) binding site [chemical binding]; other site
590409002297	homodimer interface [polypeptide binding]; other site
590409002298	substrate binding site [chemical binding]; other site
590409002299	active site
590409002300	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
590409002301	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
590409002302	NAD(P) binding site [chemical binding]; other site
590409002303	active site
590409002304	Bacterial sugar transferase; Region: Bac_transf; pfam02397
590409002305	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
590409002306	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
590409002307	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
590409002308	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
590409002309	Walker A/P-loop; other site
590409002310	ATP binding site [chemical binding]; other site
590409002311	Q-loop/lid; other site
590409002312	ABC transporter signature motif; other site
590409002313	Walker B; other site
590409002314	D-loop; other site
590409002315	H-loop/switch region; other site
590409002316	TOBE domain; Region: TOBE_2; pfam08402
590409002317	Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402
590409002318	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
590409002319	active site
590409002320	metal binding site [ion binding]; metal-binding site
590409002321	hexamer interface [polypeptide binding]; other site
590409002322	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
590409002323	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
590409002324	dimer interface [polypeptide binding]; other site
590409002325	conserved gate region; other site
590409002326	putative PBP binding loops; other site
590409002327	ABC-ATPase subunit interface; other site
590409002328	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
590409002329	dimer interface [polypeptide binding]; other site
590409002330	conserved gate region; other site
590409002331	putative PBP binding loops; other site
590409002332	ABC-ATPase subunit interface; other site
590409002333	TOBE domain; Region: TOBE; cl01440
590409002334	TOBE domain; Region: TOBE; cl01440
590409002335	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
590409002336	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
590409002337	putative acyl-acceptor binding pocket; other site
590409002338	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
590409002339	Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831
590409002340	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
590409002341	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480
590409002342	Na binding site [ion binding]; other site
590409002343	Predicted membrane protein [Function unknown]; Region: COG3162
590409002344	acetyl-CoA synthetase; Provisional; Region: PRK00174
590409002345	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
590409002346	active site
590409002347	CoA binding site [chemical binding]; other site
590409002348	acyl-activating enzyme (AAE) consensus motif; other site
590409002349	AMP binding site [chemical binding]; other site
590409002350	acetate binding site [chemical binding]; other site
590409002351	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465
590409002352	Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211
590409002353	melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392
590409002354	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
590409002355	non-specific DNA binding site [nucleotide binding]; other site
590409002356	salt bridge; other site
590409002357	sequence-specific DNA binding site [nucleotide binding]; other site
590409002358	Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246
590409002359	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
590409002360	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
590409002361	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
590409002362	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
590409002363	efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998
590409002364	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
590409002365	HlyD family secretion protein; Region: HlyD_3; pfam13437
590409002366	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
590409002367	MarR family; Region: MarR_2; pfam12802
590409002368	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
590409002369	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
590409002370	DNA-binding site [nucleotide binding]; DNA binding site
590409002371	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
590409002372	pyridoxal 5'-phosphate binding site [chemical binding]; other site
590409002373	homodimer interface [polypeptide binding]; other site
590409002374	catalytic residue [active]
590409002375	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
590409002376	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
590409002377	L,D-transpeptidase; Provisional; Region: PRK10260
590409002378	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
590409002379	pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176
590409002380	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
590409002381	dimer interface [polypeptide binding]; other site
590409002382	PYR/PP interface [polypeptide binding]; other site
590409002383	TPP binding site [chemical binding]; other site
590409002384	substrate binding site [chemical binding]; other site
590409002385	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
590409002386	Domain of unknown function; Region: EKR; smart00890
590409002387	4Fe-4S binding domain; Region: Fer4_6; pfam12837
590409002388	4Fe-4S binding domain; Region: Fer4; pfam00037
590409002389	Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377
590409002390	TPP-binding site [chemical binding]; other site
590409002391	dimer interface [polypeptide binding]; other site
590409002392	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
590409002393	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
590409002394	lipoprotein; Reviewed; Region: PRK02939
590409002395	DinI-like family; Region: DinI; cl11630
590409002396	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
590409002397	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
590409002398	Coenzyme A binding pocket [chemical binding]; other site
590409002399	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
590409002400	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
590409002401	active site
590409002402	YCII-related domain; Region: YCII; cl00999
590409002403	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
590409002404	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
590409002405	D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478
590409002406	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
590409002407	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
590409002408	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
590409002409	putative active site [active]
590409002410	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
590409002411	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
590409002412	tetrameric interface [polypeptide binding]; other site
590409002413	NAD binding site [chemical binding]; other site
590409002414	catalytic residues [active]
590409002415	Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962
590409002416	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
590409002417	PYR/PP interface [polypeptide binding]; other site
590409002418	dimer interface [polypeptide binding]; other site
590409002419	TPP binding site [chemical binding]; other site
590409002420	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
590409002421	Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003
590409002422	TPP-binding site; other site
590409002423	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
590409002424	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
590409002425	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
590409002426	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
590409002427	Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
590409002428	ligand binding site [chemical binding]; other site
590409002429	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
590409002430	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
590409002431	Walker A/P-loop; other site
590409002432	ATP binding site [chemical binding]; other site
590409002433	Q-loop/lid; other site
590409002434	ABC transporter signature motif; other site
590409002435	Walker B; other site
590409002436	D-loop; other site
590409002437	H-loop/switch region; other site
590409002438	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
590409002439	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
590409002440	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
590409002441	TM-ABC transporter signature motif; other site
590409002442	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
590409002443	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
590409002444	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
590409002445	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
590409002446	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
590409002447	substrate binding site [chemical binding]; other site
590409002448	ATP binding site [chemical binding]; other site
590409002449	Uncharacterized protein conserved in bacteria (DUF2090); Region: DUF2090; pfam09863
590409002450	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3892
590409002451	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
590409002452	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
590409002453	Metal-binding active site; metal-binding site
590409002454	Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718
590409002455	Transglycosylase SLT domain; Region: SLT_2; pfam13406
590409002456	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
590409002457	N-acetyl-D-glucosamine binding site [chemical binding]; other site
590409002458	catalytic residue [active]
590409002459	Uncharacterized membrane protein [Function unknown]; Region: SpmB; cl17667
590409002460	Uncharacterized membrane protein [Function unknown]; Region: SpmB; cl17667
590409002461	histidine ABC transporter substrate-binding protein HisJ; Provisional; Region: PRK15437
590409002462	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
590409002463	substrate binding pocket [chemical binding]; other site
590409002464	membrane-bound complex binding site; other site
590409002465	hinge residues; other site
590409002466	MEKHLA domain; Region: MEKHLA; pfam08670
590409002467	Transposase; Region: DEDD_Tnp_IS110; pfam01548
590409002468	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
590409002469	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
590409002470	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
590409002471	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
590409002472	DNA-binding interface [nucleotide binding]; DNA binding site
590409002473	integrase; Provisional; Region: int; PHA02601
590409002474	Phage HP1 integrase, C-terminal catalytic domain. Bacteriophage HP1 and related integrases are found in eubacteria, plasmids and temperate bacteriophages of the P2 family.  They belong to the DNA breaking-rejoining enzyme superfamily, which includes...; Region: HP1_INT_C; cd00797
590409002475	dimer interface [polypeptide binding]; other site
590409002476	active site
590409002477	catalytic residues [active]
590409002478	Int/Topo IB signature motif; other site
590409002479	Predicted transcriptional regulator [Transcription]; Region: COG2932
590409002480	Bacteriophage CI repressor helix-turn-helix domain; Region: Phage_CI_repr; pfam07022
590409002481	Phage regulatory protein CII (CP76); Region: Phage_CP76; pfam06892
590409002482	Protein of unknown function (DUF2732); Region: DUF2732; pfam10809
590409002483	Bacteriophage replication gene A protein (GPA); Region: Phage_GPA; pfam05840
590409002484	Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606
590409002485	Phage-related protein [Function unknown]; Region: COG4695; cl01923
590409002486	Phage portal protein; Region: Phage_portal; pfam04860
590409002487	terminase ATPase subunit; Provisional; Region: P; PHA02535
590409002488	Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056
590409002489	Mu-like prophage FluMu protein gp28 [General function prediction only]; Region: COG4373
590409002490	Phage capsid scaffolding protein (GPO) serine peptidase; Region: Phage_GPO; cl15838
590409002491	Phage major capsid protein, P2 family; Region: Phage_cap_P2; cl04947
590409002492	terminase endonuclease subunit; Provisional; Region: M; PHA02537
590409002493	Phage small terminase subunit; Region: Phage_term_smal; pfam05944
590409002494	Phage head completion protein (GPL); Region: Phage_GPL; pfam05926
590409002495	P2 phage tail completion protein R (GpR); Region: P2_Phage_GpR; pfam06891
590409002496	Protein of unknown function (DUF2586); Region: DUF2586; pfam10758
590409002497	Protein of unknown function (DUF2597); Region: DUF2597; pfam10772
590409002498	Phage holin family 2; Region: Phage_holin_2; pfam04550
590409002499	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539
590409002500	Protein of unknown function (DUF2765); Region: DUF2765; pfam10963
590409002501	Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145
590409002502	Protein of unknown function (DUF2590); Region: DUF2590; pfam10761
590409002503	Baseplate J-like protein; Region: Baseplate_J; cl01294
590409002504	Baseplate J-like protein; Region: Baseplate_J; pfam04865
590409002505	Phage tail-collar fibre protein; Region: DUF3751; pfam12571
590409002506	Phage Tail Collar Domain; Region: Collar; pfam07484
590409002507	Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413
590409002508	Uncharacterized protein family UPF0547; Region: UPF0547; pfam10571
590409002509	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
590409002510	SmpB-tmRNA interface; other site
590409002511	Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813
590409002512	putative coenzyme Q binding site [chemical binding]; other site
590409002513	hypothetical protein; Validated; Region: PRK01777
590409002514	outer membrane biogenesis protein BamE; Provisional; Region: PRK11548
590409002515	SmpA / OmlA family; Region: SmpA_OmlA; pfam04355
590409002516	recombination and repair protein; Provisional; Region: PRK10869
590409002517	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
590409002518	Walker A/P-loop; other site
590409002519	ATP binding site [chemical binding]; other site
590409002520	Q-loop/lid; other site
590409002521	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
590409002522	ABC transporter signature motif; other site
590409002523	Walker B; other site
590409002524	D-loop; other site
590409002525	H-loop/switch region; other site
590409002526	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03378
590409002527	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231
590409002528	Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576
590409002529	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
590409002530	dimer interface [polypeptide binding]; other site
590409002531	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
590409002532	manganese transport protein MntH; Reviewed; Region: PRK00701
590409002533	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
590409002534	GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009
590409002535	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
590409002536	dimer interface [polypeptide binding]; other site
590409002537	ADP-ribose binding site [chemical binding]; other site
590409002538	active site
590409002539	nudix motif; other site
590409002540	metal binding site [ion binding]; metal-binding site
590409002541	transaldolase-like protein; Provisional; Region: PTZ00411
590409002542	Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957
590409002543	active site
590409002544	dimer interface [polypeptide binding]; other site
590409002545	catalytic residue [active]
590409002546	bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232
590409002547	Malic enzyme, N-terminal domain; Region: malic; pfam00390
590409002548	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
590409002549	putative NAD(P) binding site [chemical binding]; other site
590409002550	Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280
590409002551	hypothetical protein; Validated; Region: PRK00124
590409002552	coproporphyrinogen III oxidase; Provisional; Region: PRK05330
590409002553	Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218
590409002554	putative acetyltransferase; Provisional; Region: PRK03624
590409002555	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
590409002556	Coenzyme A binding pocket [chemical binding]; other site
590409002557	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
590409002558	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
590409002559	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
590409002560	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
590409002561	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
590409002562	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
590409002563	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
590409002564	ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178
590409002565	ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549
590409002566	ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223
590409002567	RpoE-regulated lipoprotein; Provisional; Region: PRK10718
590409002568	Protein of unknown function (DUF1131); Region: DUF1131; pfam06572
590409002569	Domain of unknown function (DUF1870); Region: DUF1870; pfam08965
590409002570	benzoate transport; Region: 2A0115; TIGR00895
590409002571	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
590409002572	putative substrate translocation pore; other site
590409002573	Transcriptional regulator [Transcription]; Region: LysR; COG0583
590409002574	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
590409002575	The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434
590409002576	putative dimerization interface [polypeptide binding]; other site
590409002577	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
590409002578	Major Facilitator Superfamily; Region: MFS_1; pfam07690
590409002579	putative substrate translocation pore; other site
590409002580	quinate/shikimate dehydrogenase; Reviewed; Region: PRK12749
590409002581	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
590409002582	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
590409002583	shikimate binding site; other site
590409002584	NAD(P) binding site [chemical binding]; other site
590409002585	3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710
590409002586	Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502
590409002587	active site
590409002588	catalytic residue [active]
590409002589	dimer interface [polypeptide binding]; other site
590409002590	Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670
590409002591	Coenzyme A transferase; Region: CoA_trans; smart00882
590409002592	Coenzyme A transferase; Region: CoA_trans; cl17247
590409002593	putative acyl-CoA dehydrogenase; Provisional; Region: PRK12341
590409002594	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
590409002595	active site
590409002596	Cupin domain; Region: Cupin_2; pfam07883
590409002597	Winged helix DNA-binding domain (DUF1495); Region: DUF1495; cl01336
590409002598	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
590409002599	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
590409002600	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
590409002601	Ligand binding site [chemical binding]; other site
590409002602	Electron transfer flavoprotein domain; Region: ETF; pfam01012
590409002603	electron transfer flavoprotein subunit YdiR; Provisional; Region: PRK11916
590409002604	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
590409002605	Ligand Binding Site [chemical binding]; other site
590409002606	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
590409002607	oxidoreductase; Provisional; Region: PRK10015
590409002608	ferredoxin-like protein FixX; Provisional; Region: PRK15449
590409002609	short chain acyl-CoA synthetase; Reviewed; Region: PRK06087
590409002610	Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); Region: CHC_CoA_lg; cd05903
590409002611	acyl-activating enzyme (AAE) consensus motif; other site
590409002612	putative AMP binding site [chemical binding]; other site
590409002613	putative active site [active]
590409002614	putative CoA binding site [chemical binding]; other site
590409002615	Winged helix-turn-helix DNA-binding; Region: HTH_35; pfam13693
590409002616	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
590409002617	Coenzyme A binding pocket [chemical binding]; other site
590409002618	PAS fold; Region: PAS_4; pfam08448
590409002619	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
590409002620	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
590409002621	DNA binding residues [nucleotide binding]
590409002622	dimerization interface [polypeptide binding]; other site
590409002623	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
590409002624	Na binding site [ion binding]; other site
590409002625	Dyp-type peroxidase family; Region: Dyp_perox; pfam04261
590409002626	cysteine synthase B; Region: cysM; TIGR01138
590409002627	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
590409002628	dimer interface [polypeptide binding]; other site
590409002629	pyridoxal 5'-phosphate binding site [chemical binding]; other site
590409002630	catalytic residue [active]
590409002631	macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535
590409002632	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
590409002633	Walker A/P-loop; other site
590409002634	ATP binding site [chemical binding]; other site
590409002635	Q-loop/lid; other site
590409002636	ABC transporter signature motif; other site
590409002637	Walker B; other site
590409002638	D-loop; other site
590409002639	H-loop/switch region; other site
590409002640	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
590409002641	FtsX-like permease family; Region: FtsX; pfam02687
590409002642	macrolide transporter subunit MacA; Provisional; Region: PRK11578
590409002643	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
590409002644	HlyD family secretion protein; Region: HlyD_3; pfam13437
590409002645	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
590409002646	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
590409002647	active site
590409002648	phosphorylation site [posttranslational modification]
590409002649	intermolecular recognition site; other site
590409002650	dimerization interface [polypeptide binding]; other site
590409002651	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
590409002652	DNA binding site [nucleotide binding]
590409002653	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
590409002654	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
590409002655	dimerization interface [polypeptide binding]; other site
590409002656	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
590409002657	dimer interface [polypeptide binding]; other site
590409002658	phosphorylation site [posttranslational modification]
590409002659	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
590409002660	ATP binding site [chemical binding]; other site
590409002661	Mg2+ binding site [ion binding]; other site
590409002662	G-X-G motif; other site
590409002663	enoyl-CoA hydratase; Provisional; Region: PRK06563
590409002664	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
590409002665	substrate binding site [chemical binding]; other site
590409002666	oxyanion hole (OAH) forming residues; other site
590409002667	trimer interface [polypeptide binding]; other site
590409002668	Predicted transcriptional regulators [Transcription]; Region: COG1733
590409002669	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
590409002670	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210
590409002671	HPr interaction site; other site
590409002672	glycerol kinase (GK) interaction site [polypeptide binding]; other site
590409002673	active site
590409002674	phosphorylation site [posttranslational modification]
590409002675	phosphoenolpyruvate-protein phosphotransferase; Provisional; Region: PRK11177
590409002676	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
590409002677	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
590409002678	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
590409002679	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
590409002680	dimerization domain swap beta strand [polypeptide binding]; other site
590409002681	regulatory protein interface [polypeptide binding]; other site
590409002682	active site
590409002683	regulatory phosphorylation site [posttranslational modification]; other site
590409002684	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
590409002685	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
590409002686	dimer interface [polypeptide binding]; other site
590409002687	pyridoxal 5'-phosphate binding site [chemical binding]; other site
590409002688	catalytic residue [active]
590409002689	Transposase; Region: DEDD_Tnp_IS110; pfam01548
590409002690	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
590409002691	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
590409002692	putative sulfate transport protein CysZ; Validated; Region: PRK04949
590409002693	cell division protein ZipA; Provisional; Region: PRK03427
590409002694	ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cd00231
590409002695	FtsZ protein binding site [polypeptide binding]; other site
590409002696	putative transporter; Provisional; Region: PRK11021
590409002697	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2960
590409002698	3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353
590409002699	3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108
590409002700	tellurite resistance protein TehB; Provisional; Region: PRK12335
590409002701	Uncharacterized protein/domain, possibly involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TehB; COG3615
590409002702	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
590409002703	S-adenosylmethionine binding site [chemical binding]; other site
590409002704	NADH:flavorubredoxin oxidoreductase; Provisional; Region: PRK04965
590409002705	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
590409002706	anaerobic nitric oxide reductase flavorubredoxin; Provisional; Region: PRK05452
590409002707	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
590409002708	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
590409002709	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
590409002710	iron binding site [ion binding]; other site
590409002711	anaerobic nitric oxide reductase transcription regulator; Provisional; Region: PRK05022
590409002712	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
590409002713	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
590409002714	Walker A motif; other site
590409002715	ATP binding site [chemical binding]; other site
590409002716	Walker B motif; other site
590409002717	arginine finger; other site
590409002718	fumarate hydratase; Provisional; Region: PRK15389
590409002719	Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951
590409002720	Fumarase C-terminus; Region: Fumerase_C; pfam05683
590409002721	Transcriptional regulator [Transcription]; Region: LysR; COG0583
590409002722	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
590409002723	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
590409002724	dimerization interface [polypeptide binding]; other site
590409002725	Predicted membrane protein [Function unknown]; Region: COG4125
590409002726	Bacterial Transmembrane Pair family; Region: BTP; pfam05232
590409002727	Bacterial Transmembrane Pair family; Region: BTP; pfam05232
590409002728	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
590409002729	endonuclease III; Region: ENDO3c; smart00478
590409002730	minor groove reading motif; other site
590409002731	helix-hairpin-helix signature motif; other site
590409002732	substrate binding pocket [chemical binding]; other site
590409002733	active site
590409002734	alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401
590409002735	hypothetical protein; Validated; Region: PRK07121
590409002736	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
590409002737	FMN-binding domain; Region: FMN_bind; pfam04205
590409002738	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
590409002739	putative transporter; Provisional; Region: PRK10504
590409002740	putative substrate translocation pore; other site
590409002741	cytochrome c nitrite reductase, NrfD subunit; Region: cyt_nit_nrfD; TIGR03148
590409002742	cytochrome c nitrite reductase, Fe-S protein; Region: cyt_nit_nrfC; TIGR03149
590409002743	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
590409002744	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
590409002745	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
590409002746	substrate binding pocket [chemical binding]; other site
590409002747	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
590409002748	Transcriptional regulator [Transcription]; Region: LysR; COG0583
590409002749	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
590409002750	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
590409002751	dimerization interface [polypeptide binding]; other site
590409002752	Transcriptional regulators [Transcription]; Region: PurR; COG1609
590409002753	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
590409002754	DNA binding site [nucleotide binding]
590409002755	domain linker motif; other site
590409002756	Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_2; cd06278
590409002757	putative dimerization interface [polypeptide binding]; other site
590409002758	putative ligand binding site [chemical binding]; other site
590409002759	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
590409002760	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
590409002761	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
590409002762	Walker A/P-loop; other site
590409002763	ATP binding site [chemical binding]; other site
590409002764	Q-loop/lid; other site
590409002765	ABC transporter signature motif; other site
590409002766	Walker B; other site
590409002767	D-loop; other site
590409002768	H-loop/switch region; other site
590409002769	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
590409002770	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
590409002771	dimer interface [polypeptide binding]; other site
590409002772	conserved gate region; other site
590409002773	putative PBP binding loops; other site
590409002774	ABC-ATPase subunit interface; other site
590409002775	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
590409002776	dimer interface [polypeptide binding]; other site
590409002777	conserved gate region; other site
590409002778	putative PBP binding loops; other site
590409002779	ABC-ATPase subunit interface; other site
590409002780	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
590409002781	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
590409002782	drug efflux system protein MdtG; Provisional; Region: PRK09874
590409002783	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
590409002784	putative substrate translocation pore; other site
590409002785	Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473
590409002786	tartrate dehydrogenase; Region: TTC; TIGR02089
590409002787	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
590409002788	transcriptional activator TtdR; Provisional; Region: PRK09801
590409002789	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479
590409002790	putative effector binding pocket; other site
590409002791	putative dimerization interface [polypeptide binding]; other site
590409002792	7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792
590409002793	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904
590409002794	Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780
590409002795	Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; pfam02592
590409002796	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
590409002797	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
590409002798	non-specific DNA binding site [nucleotide binding]; other site
590409002799	salt bridge; other site
590409002800	sequence-specific DNA binding site [nucleotide binding]; other site
590409002801	hypothetical protein; Provisional; Region: PRK05208
590409002802	The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR),  trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769
590409002803	molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509
590409002804	molybdopterin cofactor binding site [chemical binding]; other site
590409002805	substrate binding site [chemical binding]; other site
590409002806	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929
590409002807	molybdopterin cofactor binding site; other site
590409002808	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
590409002809	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
590409002810	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
590409002811	dimerization interface [polypeptide binding]; other site
590409002812	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
590409002813	nudix motif; other site
590409002814	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
590409002815	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
590409002816	NAD(P) binding site [chemical binding]; other site
590409002817	active site
590409002818	MltA-interacting protein MipA; Region: MipA; cl01504
590409002819	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
590409002820	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
590409002821	active site
590409002822	phosphorylation site [posttranslational modification]
590409002823	intermolecular recognition site; other site
590409002824	dimerization interface [polypeptide binding]; other site
590409002825	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
590409002826	DNA binding site [nucleotide binding]
590409002827	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
590409002828	HAMP domain; Region: HAMP; pfam00672
590409002829	dimerization interface [polypeptide binding]; other site
590409002830	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
590409002831	dimer interface [polypeptide binding]; other site
590409002832	phosphorylation site [posttranslational modification]
590409002833	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
590409002834	ATP binding site [chemical binding]; other site
590409002835	Mg2+ binding site [ion binding]; other site
590409002836	G-X-G motif; other site
590409002837	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
590409002838	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
590409002839	HlyD family secretion protein; Region: HlyD_3; pfam13437
590409002840	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
590409002841	F plasmid transfer operon, TraF, protein; Region: TraF_2; pfam13729
590409002842	Predicted transcriptional regulators [Transcription]; Region: COG1733
590409002843	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
590409002844	AAA domain; Region: AAA_17; pfam13207
590409002845	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
590409002846	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
590409002847	intersubunit interface [polypeptide binding]; other site
590409002848	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_4; pfam14281
590409002849	Fic family protein [Function unknown]; Region: COG3177
590409002850	Fic/DOC family; Region: Fic; pfam02661
590409002851	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
590409002852	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
590409002853	non-specific DNA binding site [nucleotide binding]; other site
590409002854	salt bridge; other site
590409002855	sequence-specific DNA binding site [nucleotide binding]; other site
590409002856	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
590409002857	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
590409002858	non-specific DNA binding site [nucleotide binding]; other site
590409002859	salt bridge; other site
590409002860	sequence-specific DNA binding site [nucleotide binding]; other site
590409002861	Winged helix-turn-helix DNA-binding; Region: HTH_35; pfam13693
590409002862	integrase; Provisional; Region: PRK09692
590409002863	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
590409002864	active site
590409002865	Int/Topo IB signature motif; other site
590409002866	ornithine decarboxylase; Provisional; Region: PRK13578
590409002867	Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709
590409002868	Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615
590409002869	homodimer interface [polypeptide binding]; other site
590409002870	pyridoxal 5'-phosphate binding site [chemical binding]; other site
590409002871	catalytic residue [active]
590409002872	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
590409002873	L-asparagine permease; Provisional; Region: PRK15049
590409002874	murein transglycosylase C; Provisional; Region: mltC; PRK11671
590409002875	Domain of unknown function (DUF3393); Region: DUF3393; pfam11873
590409002876	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
590409002877	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
590409002878	N-acetyl-D-glucosamine binding site [chemical binding]; other site
590409002879	catalytic residue [active]
590409002880	oxidative damage protection protein; Provisional; Region: PRK05408
590409002881	adenine DNA glycosylase; Provisional; Region: PRK10880
590409002882	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
590409002883	minor groove reading motif; other site
590409002884	helix-hairpin-helix signature motif; other site
590409002885	substrate binding pocket [chemical binding]; other site
590409002886	active site
590409002887	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
590409002888	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
590409002889	DNA binding and oxoG recognition site [nucleotide binding]
590409002890	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
590409002891	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
590409002892	S-adenosylmethionine binding site [chemical binding]; other site
590409002893	hypothetical protein; Provisional; Region: PRK11702
590409002894	hypothetical protein; Provisional; Region: PRK10626
590409002895	Protein of unknown function (DUF2884); Region: DUF2884; pfam11101
590409002896	Peptidase S8 family domain in Autotransporter serine proteases; Region: Peptidases_S8_Autotransporter_serine_protease_like; cd04848
590409002897	catalytic triad [active]
590409002898	putative active site [active]
590409002899	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
590409002900	outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414
590409002901	Autotransporter beta-domain; Region: Autotransporter; pfam03797
590409002902	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
590409002903	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
590409002904	active site
590409002905	catalytic tetrad [active]
590409002906	Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004
590409002907	Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861
590409002908	MutH is a 28kD endonuclease involved in methyl-directed DNA mismatch repair in gram negative bacteria. MutH is both sequence-specific and methylation-specific, introducing a nick in the unmethylated strand of a hemi-methylated d(GATC) DNA duplex.   MutH...; Region: MutH_Sau3AI; cd00583
590409002909	putative DNA-binding cleft [nucleotide binding]; other site
590409002910	putative DNA clevage site; other site
590409002911	molecular lever; other site
590409002912	Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671
590409002913	putative active site [active]
590409002914	Ap4A binding site [chemical binding]; other site
590409002915	nudix motif; other site
590409002916	putative metal binding site [ion binding]; other site
590409002917	fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain; Provisional; Region: PRK11061
590409002918	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
590409002919	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
590409002920	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
590409002921	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
590409002922	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
590409002923	thymidylate synthase; Reviewed; Region: thyA; PRK01827
590409002924	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
590409002925	dimerization interface [polypeptide binding]; other site
590409002926	active site
590409002927	hypothetical protein; Provisional; Region: PRK10506
590409002928	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
590409002929	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
590409002930	hypothetical protein; Provisional; Region: PRK10557
590409002931	Protein of unknown function (DUF2509); Region: DUF2509; cl11672
590409002932	Prepilin peptidase dependent protein C term (DUF3728); Region: DUF3728; pfam12528
590409002933	protease3; Provisional; Region: PRK15101
590409002934	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
590409002935	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
590409002936	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
590409002937	N-acetylglutamate synthase; Validated; Region: PRK05279
590409002938	AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237
590409002939	putative feedback inhibition sensing region; other site
590409002940	putative nucleotide binding site [chemical binding]; other site
590409002941	putative substrate binding site [chemical binding]; other site
590409002942	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
590409002943	Coenzyme A binding pocket [chemical binding]; other site
590409002944	AMIN domain; Region: AMIN; pfam11741
590409002945	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
590409002946	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
590409002947	active site
590409002948	metal binding site [ion binding]; metal-binding site
590409002949	murein transglycosylase A; Provisional; Region: mltA; PRK11162
590409002950	MltA specific insert domain; Region: MltA; smart00925
590409002951	3D domain; Region: 3D; pfam06725
590409002952	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
590409002953	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
590409002954	Coenzyme A binding pocket [chemical binding]; other site
590409002955	Putative D-3-Phosphoglycerate Dehydrogenases; Region: PGDH_like_1; cd12169
590409002956	dimerization interface [polypeptide binding]; other site
590409002957	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
590409002958	NAD binding site [chemical binding]; other site
590409002959	ligand binding site [chemical binding]; other site
590409002960	catalytic site [active]
590409002961	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
590409002962	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
590409002963	Coenzyme A binding pocket [chemical binding]; other site
590409002964	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
590409002965	sulfur acceptor protein CsdL; Provisional; Region: PRK15116
590409002966	Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755
590409002967	putative ATP binding site [chemical binding]; other site
590409002968	putative substrate interface [chemical binding]; other site
590409002969	Fe-S metabolism associated domain; Region: SufE; cl00951
590409002970	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
590409002971	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
590409002972	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
590409002973	catalytic residue [active]
590409002974	Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004
590409002975	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
590409002976	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
590409002977	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
590409002978	dimerization interface [polypeptide binding]; other site
590409002979	substrate binding pocket [chemical binding]; other site
590409002980	hypothetical protein; Provisional; Region: PRK10873
590409002981	putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760
590409002982	FtsJ-like methyltransferase; Region: FtsJ; cl17430
590409002983	flap endonuclease-like protein; Provisional; Region: PRK09482
590409002984	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
590409002985	active site
590409002986	metal binding site 1 [ion binding]; metal-binding site
590409002987	putative 5' ssDNA interaction site; other site
590409002988	metal binding site 3; metal-binding site
590409002989	metal binding site 2 [ion binding]; metal-binding site
590409002990	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
590409002991	putative DNA binding site [nucleotide binding]; other site
590409002992	putative metal binding site [ion binding]; other site
590409002993	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
590409002994	Domain of unknown function (DUF3412); Region: DUF3412; pfam11892
590409002995	SecY interacting protein Syd; Provisional; Region: PRK04968
590409002996	tRNA pseudouridine synthase C; Region: DUF446; pfam04287
590409002997	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
590409002998	tRNA pseudouridine isomerase C; Region: PseudoU_synth_TruC; cd02563
590409002999	probable active site [active]
590409003000	flavodoxin; Provisional; Region: PRK08105
590409003001	hypothetical protein; Provisional; Region: PRK13677
590409003002	2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830
590409003003	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
590409003004	trimer interface [polypeptide binding]; other site
590409003005	active site
590409003006	substrate binding site [chemical binding]; other site
590409003007	CoA binding site [chemical binding]; other site
590409003008	PII uridylyl-transferase; Provisional; Region: PRK05007
590409003009	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
590409003010	metal binding triad; other site
590409003011	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
590409003012	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
590409003013	Zn2+ binding site [ion binding]; other site
590409003014	Mg2+ binding site [ion binding]; other site
590409003015	ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900
590409003016	C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899
590409003017	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
590409003018	active site
590409003019	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
590409003020	rRNA interaction site [nucleotide binding]; other site
590409003021	S8 interaction site; other site
590409003022	putative laminin-1 binding site; other site
590409003023	elongation factor Ts; Provisional; Region: tsf; PRK09377
590409003024	UBA/TS-N domain; Region: UBA; pfam00627
590409003025	Elongation factor TS; Region: EF_TS; pfam00889
590409003026	Elongation factor TS; Region: EF_TS; pfam00889
590409003027	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
590409003028	putative nucleotide binding site [chemical binding]; other site
590409003029	uridine monophosphate binding site [chemical binding]; other site
590409003030	homohexameric interface [polypeptide binding]; other site
590409003031	ribosome recycling factor; Reviewed; Region: frr; PRK00083
590409003032	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
590409003033	hinge region; other site
590409003034	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
590409003035	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
590409003036	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
590409003037	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
590409003038	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
590409003039	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
590409003040	catalytic residue [active]
590409003041	putative FPP diphosphate  binding site; other site
590409003042	putative FPP binding hydrophobic cleft; other site
590409003043	dimer interface [polypeptide binding]; other site
590409003044	putative IPP diphosphate binding site; other site
590409003045	CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624
590409003046	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
590409003047	zinc metallopeptidase RseP; Provisional; Region: PRK10779
590409003048	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
590409003049	active site
590409003050	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
590409003051	protein binding site [polypeptide binding]; other site
590409003052	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
590409003053	protein binding site [polypeptide binding]; other site
590409003054	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
590409003055	putative substrate binding region [chemical binding]; other site
590409003056	outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067
590409003057	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
590409003058	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
590409003059	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
590409003060	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
590409003061	Surface antigen; Region: Bac_surface_Ag; pfam01103
590409003062	Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: HlpA; COG2825
590409003063	periplasmic chaperone; Provisional; Region: PRK10780
590409003064	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
590409003065	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
590409003066	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
590409003067	trimer interface [polypeptide binding]; other site
590409003068	active site
590409003069	UDP-GlcNAc binding site [chemical binding]; other site
590409003070	lipid binding site [chemical binding]; lipid-binding site
590409003071	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
590409003072	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
590409003073	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
590409003074	active site
590409003075	lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025
590409003076	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
590409003077	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
590409003078	RNA/DNA hybrid binding site [nucleotide binding]; other site
590409003079	active site
590409003080	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
590409003081	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433
590409003082	putative active site [active]
590409003083	putative PHP Thumb interface [polypeptide binding]; other site
590409003084	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
590409003085	generic binding surface II; other site
590409003086	generic binding surface I; other site
590409003087	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
590409003088	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
590409003089	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352
590409003090	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
590409003091	putative metal binding site [ion binding]; other site
590409003092	tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660
590409003093	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
590409003094	Ligand Binding Site [chemical binding]; other site
590409003095	TilS substrate binding domain; Region: TilS; pfam09179
590409003096	TilS substrate C-terminal domain; Region: TilS_C; pfam11734
590409003097	Rho-binding antiterminator; Provisional; Region: PRK11625
590409003098	hypothetical protein; Provisional; Region: PRK04964
590409003099	YaeQ protein; Region: YaeQ; pfam07152
590409003100	NlpE N-terminal domain; Region: NlpE; pfam04170
590409003101	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
590409003102	MutS domain I; Region: MutS_I; pfam01624
590409003103	MutS domain II; Region: MutS_II; pfam05188
590409003104	MutS domain III; Region: MutS_III; pfam05192
590409003105	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
590409003106	Walker A/P-loop; other site
590409003107	ATP binding site [chemical binding]; other site
590409003108	Q-loop/lid; other site
590409003109	ABC transporter signature motif; other site
590409003110	Walker B; other site
590409003111	D-loop; other site
590409003112	H-loop/switch region; other site
590409003113	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
590409003114	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
590409003115	dimerization interface [polypeptide binding]; other site
590409003116	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
590409003117	dimer interface [polypeptide binding]; other site
590409003118	putative CheW interface [polypeptide binding]; other site
590409003119	2-dehydropantoate 2-reductase; Provisional; Region: PRK12921
590409003120	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
590409003121	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
590409003122	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
590409003123	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
590409003124	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
590409003125	substrate binding site [chemical binding]; other site
590409003126	Aspartyl/Asparaginyl beta-hydroxylase; Region: Asp_Arg_Hydrox; cl17820
590409003127	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
590409003128	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
590409003129	Coenzyme A binding pocket [chemical binding]; other site
590409003130	TfuA-like protein; Region: TfuA; pfam07812
590409003131	Uncharacterized conserved protein [Function unknown]; Region: COG1944
590409003132	YcaO-like family; Region: YcaO; pfam02624
590409003133	Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192
590409003134	Carbamoyltransferase; Region: CmcH_NodU; pfam02543
590409003135	Protein of unknown function (DUF692); Region: DUF692; cl01263
590409003136	molybdopterin biosynthesis protein MoeB; Validated; Region: PRK08762
590409003137	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
590409003138	active site residue [active]
590409003139	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
590409003140	ATP binding site [chemical binding]; other site
590409003141	substrate interface [chemical binding]; other site
590409003142	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
590409003143	H+ Antiporter protein; Region: 2A0121; TIGR00900
590409003144	putative substrate translocation pore; other site
590409003145	Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824
590409003146	PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274
590409003147	PhnA protein; Region: PhnA; pfam03831
590409003148	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
590409003149	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
590409003150	metal binding site [ion binding]; metal-binding site
590409003151	active site
590409003152	I-site; other site
590409003153	Domain of unknown function (DUF1987); Region: DUF1987; pfam09345
590409003154	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the GGDEF (DiGuanylate-Cyclase (DGC)) domain. The GGDEF domain has been suggested to be homologous to the adenylyl cyclase catalytic domain and...; Region: CBS_pair_GGDEF_assoc; cd04598
590409003155	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
590409003156	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
590409003157	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
590409003158	Coenzyme A binding pocket [chemical binding]; other site
590409003159	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
590409003160	metabolite-proton symporter; Region: 2A0106; TIGR00883
590409003161	putative substrate translocation pore; other site
590409003162	hypothetical protein; Provisional; Region: PRK07079
590409003163	Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_2; cd05679
590409003164	metal binding site [ion binding]; metal-binding site
590409003165	putative dimer interface [polypeptide binding]; other site
590409003166	Transcriptional regulator [Transcription]; Region: LysR; COG0583
590409003167	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
590409003168	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
590409003169	dimerization interface [polypeptide binding]; other site
590409003170	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
590409003171	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
590409003172	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
590409003173	substrate binding site [chemical binding]; other site
590409003174	zinc-binding site [ion binding]; other site
590409003175	Bacterial L-asparaginases and related enzymes; Region: L-asparaginase_like; cd00411
590409003176	active site
590409003177	homodimer interface [polypeptide binding]; other site
590409003178	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
590409003179	Shikimate kinase; Region: SKI; pfam01202
590409003180	ADP binding site [chemical binding]; other site
590409003181	magnesium binding site [ion binding]; other site
590409003182	putative shikimate binding site; other site
590409003183	hypothetical protein; Provisional; Region: PRK10579
590409003184	Cache domain; Region: Cache_1; pfam02743
590409003185	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
590409003186	dimerization interface [polypeptide binding]; other site
590409003187	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
590409003188	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
590409003189	dimer interface [polypeptide binding]; other site
590409003190	putative CheW interface [polypeptide binding]; other site
590409003191	recombination associated protein; Reviewed; Region: rdgC; PRK00321
590409003192	fructokinase; Reviewed; Region: PRK09557
590409003193	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
590409003194	nucleotide binding site [chemical binding]; other site
590409003195	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
590409003196	AAA domain; Region: AAA_23; pfam13476
590409003197	Walker A/P-loop; other site
590409003198	ATP binding site [chemical binding]; other site
590409003199	Q-loop/lid; other site
590409003200	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
590409003201	ABC transporter signature motif; other site
590409003202	Walker B; other site
590409003203	D-loop; other site
590409003204	H-loop/switch region; other site
590409003205	exonuclease subunit SbcD; Provisional; Region: PRK10966
590409003206	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
590409003207	active site
590409003208	metal binding site [ion binding]; metal-binding site
590409003209	DNA binding site [nucleotide binding]
590409003210	Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320
590409003211	transcriptional regulator PhoB; Provisional; Region: PRK10161
590409003212	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
590409003213	active site
590409003214	phosphorylation site [posttranslational modification]
590409003215	intermolecular recognition site; other site
590409003216	dimerization interface [polypeptide binding]; other site
590409003217	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
590409003218	DNA binding site [nucleotide binding]
590409003219	phosphate regulon sensor protein; Provisional; Region: phoR; PRK11006
590409003220	Domain of unknown function (DUF3329); Region: DUF3329; pfam11808
590409003221	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
590409003222	putative active site [active]
590409003223	heme pocket [chemical binding]; other site
590409003224	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
590409003225	dimer interface [polypeptide binding]; other site
590409003226	phosphorylation site [posttranslational modification]
590409003227	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
590409003228	ATP binding site [chemical binding]; other site
590409003229	Mg2+ binding site [ion binding]; other site
590409003230	G-X-G motif; other site
590409003231	PBP superfamily domain; Region: PBP_like_2; cl17296
590409003232	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
590409003233	substrate binding site [chemical binding]; other site
590409003234	THF binding site; other site
590409003235	zinc-binding site [ion binding]; other site
590409003236	Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547
590409003237	putative proline-specific permease; Provisional; Region: proY; PRK10580
590409003238	Spore germination protein; Region: Spore_permease; cl17796
590409003239	Arginate lyase and other MDR family members; Region: AL_MDR; cd08252
590409003240	zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817
590409003241	putative NAD(P) binding site [chemical binding]; other site
590409003242	dimer interface [polypeptide binding]; other site
590409003243	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
590409003244	Beta-lactamase; Region: Beta-lactamase; pfam00144
590409003245	Transcriptional regulator [Transcription]; Region: LysR; COG0583
590409003246	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
590409003247	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_7; cd08476
590409003248	putative dimerization interface [polypeptide binding]; other site
590409003249	putative effector binding pocket; other site
590409003250	DNA-directed RNA polymerase subunit beta'/alpha domain fusion protein; Provisional; Region: PRK14906
590409003251	peroxidase; Provisional; Region: PRK15000
590409003252	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
590409003253	dimer interface [polypeptide binding]; other site
590409003254	decamer (pentamer of dimers) interface [polypeptide binding]; other site
590409003255	catalytic triad [active]
590409003256	peroxidatic and resolving cysteines [active]
590409003257	Protein of unknown function, DUF479; Region: DUF479; cl01203
590409003258	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
590409003259	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
590409003260	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
590409003261	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
590409003262	preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585
590409003263	SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721
590409003264	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
590409003265	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
590409003266	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
590409003267	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
590409003268	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
590409003269	Protein export membrane protein; Region: SecD_SecF; pfam02355
590409003270	hypothetical protein; Provisional; Region: PRK11530
590409003271	magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517
590409003272	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
590409003273	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
590409003274	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
590409003275	haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710
590409003276	Soluble P-type ATPase [General function prediction only]; Region: COG4087
590409003277	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
590409003278	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
590409003279	ATP cone domain; Region: ATP-cone; pfam03477
590409003280	bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786
590409003281	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
590409003282	catalytic motif [active]
590409003283	Zn binding site [ion binding]; other site
590409003284	RibD C-terminal domain; Region: RibD_C; cl17279
590409003285	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
590409003286	homopentamer interface [polypeptide binding]; other site
590409003287	active site
590409003288	Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619
590409003289	putative RNA binding site [nucleotide binding]; other site
590409003290	thiamine monophosphate kinase; Provisional; Region: PRK05731
590409003291	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
590409003292	ATP binding site [chemical binding]; other site
590409003293	dimerization interface [polypeptide binding]; other site
590409003294	Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971
590409003295	tetramer interfaces [polypeptide binding]; other site
590409003296	binuclear metal-binding site [ion binding]; other site
590409003297	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
590409003298	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
590409003299	TPP-binding site; other site
590409003300	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
590409003301	PYR/PP interface [polypeptide binding]; other site
590409003302	dimer interface [polypeptide binding]; other site
590409003303	TPP binding site [chemical binding]; other site
590409003304	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
590409003305	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
590409003306	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
590409003307	substrate binding pocket [chemical binding]; other site
590409003308	chain length determination region; other site
590409003309	substrate-Mg2+ binding site; other site
590409003310	catalytic residues [active]
590409003311	aspartate-rich region 1; other site
590409003312	active site lid residues [active]
590409003313	aspartate-rich region 2; other site
590409003314	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
590409003315	tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269
590409003316	THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716
590409003317	ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712
590409003318	Ligand Binding Site [chemical binding]; other site
590409003319	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
590409003320	active site residue [active]
590409003321	oxidative-stress-resistance chaperone; Provisional; Region: PRK11574
590409003322	Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135
590409003323	conserved cys residue [active]
590409003324	2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522
590409003325	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
590409003326	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
590409003327	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666
590409003328	Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740
590409003329	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
590409003330	Major Facilitator Superfamily; Region: MFS_1; pfam07690
590409003331	putative substrate translocation pore; other site
590409003332	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
590409003333	protoheme IX farnesyltransferase; Provisional; Region: PRK13362
590409003334	UbiA prenyltransferase family; Region: UbiA; pfam01040
590409003335	cytochrome o ubiquinol oxidase subunit IV; Provisional; Region: PRK10582
590409003336	Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863
590409003337	Subunit I/III interface [polypeptide binding]; other site
590409003338	Subunit III/IV interface [polypeptide binding]; other site
590409003339	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
590409003340	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
590409003341	D-pathway; other site
590409003342	Putative ubiquinol binding site [chemical binding]; other site
590409003343	Low-spin heme (heme b) binding site [chemical binding]; other site
590409003344	Putative water exit pathway; other site
590409003345	Binuclear center (heme o3/CuB) [ion binding]; other site
590409003346	K-pathway; other site
590409003347	Putative proton exit pathway; other site
590409003348	cytochrome o ubiquinol oxidase subunit II; Provisional; Region: PRK10525
590409003349	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
590409003350	COX Aromatic Rich Motif; Region: COX_ARM; pfam06481
590409003351	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
590409003352	muropeptide transporter; Reviewed; Region: ampG; PRK11902
590409003353	putative substrate translocation pore; other site
590409003354	hypothetical protein; Provisional; Region: PRK11627
590409003355	Uncharacterized lipoprotein; Region: Lipoprotein_16; pfam03923
590409003356	BolA-like protein; Region: BolA; cl00386
590409003357	trigger factor; Provisional; Region: tig; PRK01490
590409003358	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
590409003359	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
590409003360	Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740
590409003361	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
590409003362	oligomer interface [polypeptide binding]; other site
590409003363	active site residues [active]
590409003364	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
590409003365	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
590409003366	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
590409003367	Walker A motif; other site
590409003368	ATP binding site [chemical binding]; other site
590409003369	Walker B motif; other site
590409003370	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
590409003371	DNA-binding ATP-dependent protease La; Provisional; Region: PRK10787
590409003372	Found in ATP-dependent protease La (LON); Region: LON; smart00464
590409003373	Found in ATP-dependent protease La (LON); Region: LON; smart00464
590409003374	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
590409003375	Walker A motif; other site
590409003376	ATP binding site [chemical binding]; other site
590409003377	Walker B motif; other site
590409003378	arginine finger; other site
590409003379	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
590409003380	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
590409003381	IHF dimer interface [polypeptide binding]; other site
590409003382	IHF - DNA interface [nucleotide binding]; other site
590409003383	periplasmic folding chaperone; Provisional; Region: PRK10788
590409003384	SurA N-terminal domain; Region: SurA_N_3; cl07813
590409003385	PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145
590409003386	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
590409003387	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
590409003388	Ligand Binding Site [chemical binding]; other site
590409003389	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
590409003390	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
590409003391	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
590409003392	catalytic residue [active]
590409003393	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
590409003394	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
590409003395	putative DNA binding site [nucleotide binding]; other site
590409003396	putative Zn2+ binding site [ion binding]; other site
590409003397	AsnC family; Region: AsnC_trans_reg; pfam01037
590409003398	putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789
590409003399	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
590409003400	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
590409003401	Walker A/P-loop; other site
590409003402	ATP binding site [chemical binding]; other site
590409003403	Q-loop/lid; other site
590409003404	ABC transporter signature motif; other site
590409003405	Walker B; other site
590409003406	D-loop; other site
590409003407	H-loop/switch region; other site
590409003408	putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10790
590409003409	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
590409003410	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
590409003411	Walker A/P-loop; other site
590409003412	ATP binding site [chemical binding]; other site
590409003413	Q-loop/lid; other site
590409003414	ABC transporter signature motif; other site
590409003415	Walker B; other site
590409003416	D-loop; other site
590409003417	H-loop/switch region; other site
590409003418	nitrogen regulatory protein P-II 2; Provisional; Region: PRK10665
590409003419	Nitrogen regulatory protein P-II; Region: P-II; smart00938
590409003420	ammonium transporter; Provisional; Region: PRK10666
590409003421	acyl-CoA thioesterase II; Provisional; Region: PRK10526
590409003422	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
590409003423	active site
590409003424	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444
590409003425	catalytic triad [active]
590409003426	dimer interface [polypeptide binding]; other site
590409003427	Type III secretion system lipoprotein chaperone (YscW); Region: YscW; pfam09619
590409003428	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
590409003429	DNA binding site [nucleotide binding]
590409003430	active site
590409003431	gene expression modulator; Provisional; Region: PRK10945
590409003432	Hha toxicity attenuator; Provisional; Region: PRK10667
590409003433	50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831
590409003434	50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678
590409003435	multidrug efflux system protein AcrB; Provisional; Region: PRK15127
590409003436	Protein export membrane protein; Region: SecD_SecF; cl14618
590409003437	Protein export membrane protein; Region: SecD_SecF; cl14618
590409003438	multidrug efflux system transporter AcrA; Provisional; Region: PRK15030
590409003439	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
590409003440	HlyD family secretion protein; Region: HlyD_3; pfam13437
590409003441	DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668
590409003442	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
590409003443	MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361
590409003444	hypothetical protein; Provisional; Region: PRK11281
590409003445	Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794
590409003446	Mechanosensitive ion channel; Region: MS_channel; pfam00924
590409003447	Primosomal replication protein priB and priC; Region: priB_priC; cl11483
590409003448	MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910
590409003449	active site
590409003450	dinuclear metal binding site [ion binding]; other site
590409003451	dimerization interface [polypeptide binding]; other site
590409003452	hypothetical protein; Provisional; Region: PRK10527
590409003453	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
590409003454	active site
590409003455	DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994
590409003456	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
590409003457	Walker A motif; other site
590409003458	ATP binding site [chemical binding]; other site
590409003459	Walker B motif; other site
590409003460	arginine finger; other site
590409003461	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
590409003462	DNA polymerase III subunits tau domain IV DnaB-binding; Region: DNA_pol3_tau_4; pfam12168
590409003463	DNA polymerase III tau subunit V interacting with alpha; Region: DNA_pol3_tau_5; pfam12170
590409003464	hypothetical protein; Validated; Region: PRK00153
590409003465	recombination protein RecR; Reviewed; Region: recR; PRK00076
590409003466	RecR protein; Region: RecR; pfam02132
590409003467	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
590409003468	putative active site [active]
590409003469	putative metal-binding site [ion binding]; other site
590409003470	tetramer interface [polypeptide binding]; other site
590409003471	heat shock protein 90; Provisional; Region: PRK05218
590409003472	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
590409003473	ATP binding site [chemical binding]; other site
590409003474	Mg2+ binding site [ion binding]; other site
590409003475	G-X-G motif; other site
590409003476	adenylate kinase; Reviewed; Region: adk; PRK00279
590409003477	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
590409003478	AMP-binding site [chemical binding]; other site
590409003479	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
590409003480	ferrochelatase; Reviewed; Region: hemH; PRK00035
590409003481	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
590409003482	C-terminal domain interface [polypeptide binding]; other site
590409003483	active site
590409003484	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
590409003485	active site
590409003486	N-terminal domain interface [polypeptide binding]; other site
590409003487	Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651
590409003488	putative cation:proton antiport protein; Provisional; Region: PRK10669
590409003489	TrkA-N domain; Region: TrkA_N; pfam02254
590409003490	bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558
590409003491	Escherichia coli UshA and related proteins, N-terminal metallophosphatase domain; Region: MPP_UshA_N; cd07405
590409003492	active site
590409003493	metal binding site [ion binding]; metal-binding site
590409003494	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
590409003495	Cache domain; Region: Cache_2; pfam08269
590409003496	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
590409003497	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
590409003498	dimer interface [polypeptide binding]; other site
590409003499	putative CheW interface [polypeptide binding]; other site
590409003500	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
590409003501	putative deacylase active site [active]
590409003502	TraB family; Region: TraB; cl12050
590409003503	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
590409003504	metal-binding site [ion binding]
590409003505	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
590409003506	copper exporting ATPase; Provisional; Region: copA; PRK10671
590409003507	metal-binding site [ion binding]
590409003508	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
590409003509	metal-binding site [ion binding]
590409003510	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
590409003511	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
590409003512	active site
590409003513	motif I; other site
590409003514	motif II; other site
590409003515	DNA-binding transcriptional regulator CueR; Provisional; Region: PRK10227
590409003516	Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108
590409003517	DNA binding residues [nucleotide binding]
590409003518	dimer interface [polypeptide binding]; other site
590409003519	copper binding site [ion binding]; other site
590409003520	Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585
590409003521	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
590409003522	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
590409003523	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
590409003524	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
590409003525	catalytic loop [active]
590409003526	iron binding site [ion binding]; other site
590409003527	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
590409003528	dimer interface [polypeptide binding]; other site
590409003529	putative radical transfer pathway; other site
590409003530	diiron center [ion binding]; other site
590409003531	tyrosyl radical; other site
590409003532	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103
590409003533	ATP cone domain; Region: ATP-cone; pfam03477
590409003534	Class I ribonucleotide reductase; Region: RNR_I; cd01679
590409003535	active site
590409003536	dimer interface [polypeptide binding]; other site
590409003537	catalytic residues [active]
590409003538	effector binding site; other site
590409003539	R2 peptide binding site; other site
590409003540	bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134
590409003541	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
590409003542	S-adenosylmethionine binding site [chemical binding]; other site
590409003543	DNA gyrase subunit A; Validated; Region: PRK05560
590409003544	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
590409003545	CAP-like domain; other site
590409003546	active site
590409003547	primary dimer interface [polypeptide binding]; other site
590409003548	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
590409003549	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
590409003550	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
590409003551	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
590409003552	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
590409003553	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
590409003554	hybrid sensory kinase in two-component regulatory system with RcsB and YojN; Provisional; Region: PRK10841
590409003555	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
590409003556	dimer interface [polypeptide binding]; other site
590409003557	phosphorylation site [posttranslational modification]
590409003558	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
590409003559	ATP binding site [chemical binding]; other site
590409003560	Mg2+ binding site [ion binding]; other site
590409003561	G-X-G motif; other site
590409003562	RcsC Alpha-Beta-Loop (ABL); Region: RcsC; pfam09456
590409003563	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
590409003564	active site
590409003565	phosphorylation site [posttranslational modification]
590409003566	intermolecular recognition site; other site
590409003567	dimerization interface [polypeptide binding]; other site
590409003568	transcriptional regulator RcsB; Provisional; Region: PRK10840
590409003569	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
590409003570	active site
590409003571	phosphorylation site [posttranslational modification]
590409003572	intermolecular recognition site; other site
590409003573	dimerization interface [polypeptide binding]; other site
590409003574	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
590409003575	DNA binding residues [nucleotide binding]
590409003576	dimerization interface [polypeptide binding]; other site
590409003577	phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional; Region: PRK10618
590409003578	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
590409003579	dimer interface [polypeptide binding]; other site
590409003580	phosphorylation site [posttranslational modification]
590409003581	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
590409003582	ATP binding site [chemical binding]; other site
590409003583	G-X-G motif; other site
590409003584	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
590409003585	putative binding surface; other site
590409003586	active site
590409003587	menaquinone-specific isochorismate synthase; Provisional; Region: PRK15012
590409003588	chorismate binding enzyme; Region: Chorismate_bind; cl10555
590409003589	2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449
590409003590	Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037
590409003591	dimer interface [polypeptide binding]; other site
590409003592	tetramer interface [polypeptide binding]; other site
590409003593	PYR/PP interface [polypeptide binding]; other site
590409003594	TPP binding site [chemical binding]; other site
590409003595	Protein of unknown function DUF72; Region: DUF72; cl00777
590409003596	Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009
590409003597	TPP-binding site; other site
590409003598	2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Provisional; Region: PRK11126
590409003599	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
590409003600	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
590409003601	substrate binding site [chemical binding]; other site
590409003602	oxyanion hole (OAH) forming residues; other site
590409003603	trimer interface [polypeptide binding]; other site
590409003604	O-succinylbenzoate synthase; Provisional; Region: PRK05105
590409003605	o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320
590409003606	active site
590409003607	O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK09029
590409003608	O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912
590409003609	acyl-activating enzyme (AAE) consensus motif; other site
590409003610	putative AMP binding site [chemical binding]; other site
590409003611	putative active site [active]
590409003612	putative CoA binding site [chemical binding]; other site
590409003613	YfaZ precursor; Region: YfaZ; pfam07437
590409003614	hypothetical protein; Provisional; Region: PRK03673
590409003615	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
590409003616	putative MPT binding site; other site
590409003617	Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118
590409003618	ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956
590409003619	oxidoreductase; Provisional; Region: PRK08017
590409003620	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
590409003621	NADP binding site [chemical binding]; other site
590409003622	active site
590409003623	steroid binding site; other site
590409003624	Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822
590409003625	active site
590409003626	catalytic triad [active]
590409003627	oxyanion hole [active]
590409003628	switch loop; other site
590409003629	putative ABC transporter ATP-binding protein YbbA; Provisional; Region: PRK10584
590409003630	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
590409003631	Walker A/P-loop; other site
590409003632	ATP binding site [chemical binding]; other site
590409003633	Q-loop/lid; other site
590409003634	ABC transporter signature motif; other site
590409003635	Walker B; other site
590409003636	D-loop; other site
590409003637	H-loop/switch region; other site
590409003638	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
590409003639	FtsX-like permease family; Region: FtsX; pfam02687
590409003640	spermidine N1-acetyltransferase; Provisional; Region: PRK15130
590409003641	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
590409003642	Coenzyme A binding pocket [chemical binding]; other site
590409003643	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
590409003644	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
590409003645	N-terminal plug; other site
590409003646	ligand-binding site [chemical binding]; other site
590409003647	Periplasmic binding protein TroA_f.  These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea.  They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_f; cd01139
590409003648	ferrichrome/ferrioxamine B periplasmic transporter; Provisional; Region: PRK14048
590409003649	putative ligand binding residues [chemical binding]; other site
590409003650	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
590409003651	dimer interface [polypeptide binding]; other site
590409003652	conserved gate region; other site
590409003653	putative PBP binding loops; other site
590409003654	ABC-ATPase subunit interface; other site
590409003655	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
590409003656	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
590409003657	substrate binding pocket [chemical binding]; other site
590409003658	membrane-bound complex binding site; other site
590409003659	hinge residues; other site
590409003660	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
590409003661	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
590409003662	TM-ABC transporter signature motif; other site
590409003663	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
590409003664	galactose/methyl galaxtoside transporter ATP-binding protein; Provisional; Region: PRK10982
590409003665	Walker A/P-loop; other site
590409003666	ATP binding site [chemical binding]; other site
590409003667	Q-loop/lid; other site
590409003668	ABC transporter signature motif; other site
590409003669	Walker B; other site
590409003670	D-loop; other site
590409003671	H-loop/switch region; other site
590409003672	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
590409003673	methyl-galactoside ABC transporter galactose-binding periplasmic protein MglB; Provisional; Region: PRK15395
590409003674	Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539
590409003675	ligand binding site [chemical binding]; other site
590409003676	calcium binding site [ion binding]; other site
590409003677	DNA-binding transcriptional regulator GalS; Provisional; Region: PRK10401
590409003678	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
590409003679	DNA binding site [nucleotide binding]
590409003680	domain linker motif; other site
590409003681	Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270
590409003682	dimerization interface (closed form) [polypeptide binding]; other site
590409003683	ligand binding site [chemical binding]; other site
590409003684	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
590409003685	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
590409003686	active site
590409003687	substrate binding site [chemical binding]; other site
590409003688	cosubstrate binding site; other site
590409003689	catalytic site [active]
590409003690	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
590409003691	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
590409003692	dimerization interface [polypeptide binding]; other site
590409003693	putative ATP binding site [chemical binding]; other site
590409003694	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
590409003695	active site
590409003696	uracil transporter; Provisional; Region: PRK10720
590409003697	DNA replication initiation factor; Provisional; Region: PRK08084
590409003698	ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593
590409003699	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
590409003700	ArsC family; Region: ArsC; pfam03960
590409003701	catalytic residues [active]
590409003702	Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783
590409003703	Peptidase family M48; Region: Peptidase_M48; pfam01435
590409003704	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
590409003705	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
590409003706	catalytic triad [active]
590409003707	glycine cleavage system transcriptional repressor; Provisional; Region: gcvR; PRK11589
590409003708	ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_1; cd04893
590409003709	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
590409003710	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
590409003711	dihydrodipicolinate synthase; Region: dapA; TIGR00674
590409003712	dimer interface [polypeptide binding]; other site
590409003713	active site
590409003714	catalytic residue [active]
590409003715	lipoprotein; Provisional; Region: PRK11679
590409003716	NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804
590409003717	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
590409003718	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
590409003719	ATP binding site [chemical binding]; other site
590409003720	active site
590409003721	substrate binding site [chemical binding]; other site
590409003722	Predicted membrane protein [Function unknown]; Region: COG2707
590409003723	Predicted P-loop ATPase fused to an acetyltransferase [General function prediction only]; Region: COG1444
590409003724	Domain of unknown function (DUF1726); Region: DUF1726; pfam08351
590409003725	Helicase; Region: Helicase_RecD; pfam05127
590409003726	GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718
590409003727	Possible tRNA binding domain; Region: tRNA_bind_2; pfam13725
590409003728	putative hydrolase; Provisional; Region: PRK11460
590409003729	Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230
590409003730	Uncharacterized protein family (UPF0370); Region: UPF0370; pfam13980
590409003731	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876
590409003732	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
590409003733	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009
590409003734	M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891
590409003735	metal binding site [ion binding]; metal-binding site
590409003736	dimer interface [polypeptide binding]; other site
590409003737	Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035
590409003738	ArsC family; Region: ArsC; pfam03960
590409003739	putative catalytic residues [active]
590409003740	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
590409003741	DNA-binding site [nucleotide binding]; DNA binding site
590409003742	RNA-binding motif; other site
590409003743	chromosome condensation membrane protein; Provisional; Region: PRK14196
590409003744	Predicted amidohydrolase [General function prediction only]; Region: COG0388
590409003745	Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581
590409003746	putative active site [active]
590409003747	catalytic triad [active]
590409003748	putative dimer interface [polypeptide binding]; other site
590409003749	twin arginine translocase protein E; Validated; Region: tatE; PRK03625
590409003750	lipoyl synthase; Provisional; Region: PRK05481
590409003751	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
590409003752	FeS/SAM binding site; other site
590409003753	lipoate-protein ligase B; Provisional; Region: PRK14342
590409003754	hypothetical protein; Provisional; Region: PRK04998
590409003755	D-alanyl-D-alanine carboxypeptidase fraction A; Provisional; Region: PRK10793
590409003756	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
590409003757	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943
590409003758	rare lipoprotein A; Provisional; Region: PRK10672
590409003759	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
590409003760	Sporulation related domain; Region: SPOR; pfam05036
590409003761	cell wall shape-determining protein; Provisional; Region: PRK10794
590409003762	penicillin-binding protein 2; Provisional; Region: PRK10795
590409003763	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
590409003764	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
590409003765	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
590409003766	ribosome-associated protein; Provisional; Region: PRK11538
590409003767	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
590409003768	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
590409003769	active site
590409003770	(T/H)XGH motif; other site
590409003771	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574
590409003772	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
590409003773	LPS-assembly lipoprotein RlpB; Provisional; Region: PRK10796
590409003774	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
590409003775	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
590409003776	HIGH motif; other site
590409003777	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
590409003778	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
590409003779	active site
590409003780	KMSKS motif; other site
590409003781	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
590409003782	tRNA binding surface [nucleotide binding]; other site
590409003783	hypothetical protein; Provisional; Region: PRK11032
590409003784	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
590409003785	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
590409003786	Walker A/P-loop; other site
590409003787	ATP binding site [chemical binding]; other site
590409003788	Q-loop/lid; other site
590409003789	ABC transporter signature motif; other site
590409003790	Walker B; other site
590409003791	D-loop; other site
590409003792	H-loop/switch region; other site
590409003793	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
590409003794	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
590409003795	dimer interface [polypeptide binding]; other site
590409003796	conserved gate region; other site
590409003797	putative PBP binding loops; other site
590409003798	ABC-ATPase subunit interface; other site
590409003799	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
590409003800	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
590409003801	dimer interface [polypeptide binding]; other site
590409003802	conserved gate region; other site
590409003803	putative PBP binding loops; other site
590409003804	ABC-ATPase subunit interface; other site
590409003805	glutamate and aspartate transporter subunit; Provisional; Region: PRK10797
590409003806	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
590409003807	substrate binding pocket [chemical binding]; other site
590409003808	membrane-bound complex binding site; other site
590409003809	hinge residues; other site
590409003810	apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302
590409003811	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
590409003812	putative active site [active]
590409003813	catalytic triad [active]
590409003814	putative dimer interface [polypeptide binding]; other site
590409003815	magnesium/cobalt efflux protein CorC; Provisional; Region: PRK15094
590409003816	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
590409003817	Transporter associated domain; Region: CorC_HlyC; smart01091
590409003818	metal-binding heat shock protein; Provisional; Region: PRK00016
590409003819	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
590409003820	PhoH-like protein; Region: PhoH; pfam02562
590409003821	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325
590409003822	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
590409003823	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
590409003824	FeS/SAM binding site; other site
590409003825	TRAM domain; Region: TRAM; pfam01938
590409003826	2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Reviewed; Region: ubiF; PRK08020
590409003827	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
590409003828	Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910
590409003829	asparagine synthetase B; Provisional; Region: asnB; PRK09431
590409003830	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
590409003831	active site
590409003832	dimer interface [polypeptide binding]; other site
590409003833	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
590409003834	Ligand Binding Site [chemical binding]; other site
590409003835	Molecular Tunnel; other site
590409003836	MarR family; Region: MarR; pfam01047
590409003837	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
590409003838	ROK family; Region: ROK; pfam00480
590409003839	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
590409003840	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
590409003841	active site
590409003842	dimer interface [polypeptide binding]; other site
590409003843	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
590409003844	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
590409003845	active site
590409003846	trimer interface [polypeptide binding]; other site
590409003847	allosteric site; other site
590409003848	active site lid [active]
590409003849	hexamer (dimer of trimers) interface [polypeptide binding]; other site
590409003850	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
590409003851	PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998
590409003852	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
590409003853	active site turn [active]
590409003854	phosphorylation site [posttranslational modification]
590409003855	glutaminyl-tRNA synthetase; Provisional; Region: PRK05347
590409003856	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
590409003857	active site
590409003858	HIGH motif; other site
590409003859	nucleotide binding site [chemical binding]; other site
590409003860	catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807
590409003861	KMSKS motif; other site
590409003862	tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950
590409003863	ferric uptake regulator; Provisional; Region: fur; PRK09462
590409003864	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
590409003865	metal binding site 2 [ion binding]; metal-binding site
590409003866	putative DNA binding helix; other site
590409003867	metal binding site 1 [ion binding]; metal-binding site
590409003868	dimer interface [polypeptide binding]; other site
590409003869	structural Zn2+ binding site [ion binding]; other site
590409003870	flavodoxin FldA; Validated; Region: PRK09267
590409003871	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
590409003872	dimer interface [polypeptide binding]; other site
590409003873	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
590409003874	putative CheW interface [polypeptide binding]; other site
590409003875	LexA regulated protein; Provisional; Region: PRK11675
590409003876	acyl-CoA esterase; Provisional; Region: PRK10673
590409003877	PGAP1-like protein; Region: PGAP1; pfam07819
590409003878	replication initiation regulator SeqA; Provisional; Region: PRK11187
590409003879	phosphoglucomutase; Validated; Region: PRK07564
590409003880	This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801
590409003881	active site
590409003882	substrate binding site [chemical binding]; other site
590409003883	metal binding site [ion binding]; metal-binding site
590409003884	Predicted membrane protein [Function unknown]; Region: COG2510
590409003885	DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529
590409003886	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
590409003887	active site
590409003888	phosphorylation site [posttranslational modification]
590409003889	intermolecular recognition site; other site
590409003890	dimerization interface [polypeptide binding]; other site
590409003891	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
590409003892	DNA binding site [nucleotide binding]
590409003893	sensor protein KdpD; Provisional; Region: PRK10490
590409003894	Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702
590409003895	USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987
590409003896	Ligand Binding Site [chemical binding]; other site
590409003897	Domain of unknown function (DUF4118); Region: DUF4118; pfam13493
590409003898	GAF domain; Region: GAF_3; pfam13492
590409003899	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
590409003900	dimer interface [polypeptide binding]; other site
590409003901	phosphorylation site [posttranslational modification]
590409003902	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
590409003903	ATP binding site [chemical binding]; other site
590409003904	Mg2+ binding site [ion binding]; other site
590409003905	G-X-G motif; other site
590409003906	potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315
590409003907	potassium-transporting ATPase subunit B; Provisional; Region: PRK01122
590409003908	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
590409003909	potassium-transporting ATPase subunit A; Provisional; Region: PRK05482
590409003910	Protein of unknown function (DUF2517); Region: DUF2517; pfam10725
590409003911	Protein of unknown function (DUF523); Region: DUF523; pfam04463
590409003912	Uncharacterized conserved protein [Function unknown]; Region: COG3272
590409003913	Protein of unknown function (DUF1722); Region: DUF1722; cl01284
590409003914	deoxyribodipyrimidine photolyase; Provisional; Region: PRK10674
590409003915	DNA photolyase; Region: DNA_photolyase; pfam00875
590409003916	Uncharacterized conserved protein [Function unknown]; Region: COG0327
590409003917	NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371
590409003918	Allophanate hydrolase subunit 1; Region: AHS1; pfam02682
590409003919	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049
590409003920	Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984
590409003921	LamB/YcsF family protein; Provisional; Region: PRK05406
590409003922	Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114
590409003923	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
590409003924	dimer interface [polypeptide binding]; other site
590409003925	active site
590409003926	citrylCoA binding site [chemical binding]; other site
590409003927	NADH binding [chemical binding]; other site
590409003928	cationic pore residues; other site
590409003929	oxalacetate/citrate binding site [chemical binding]; other site
590409003930	coenzyme A binding site [chemical binding]; other site
590409003931	catalytic triad [active]
590409003932	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499
590409003933	Iron-sulfur protein interface; other site
590409003934	proximal quinone binding site [chemical binding]; other site
590409003935	SdhD (CybS) interface [polypeptide binding]; other site
590409003936	proximal heme binding site [chemical binding]; other site
590409003937	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494
590409003938	SdhC subunit interface [polypeptide binding]; other site
590409003939	proximal heme binding site [chemical binding]; other site
590409003940	cardiolipin binding site; other site
590409003941	Iron-sulfur protein interface; other site
590409003942	proximal quinone binding site [chemical binding]; other site
590409003943	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958
590409003944	L-aspartate oxidase; Provisional; Region: PRK06175
590409003945	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
590409003946	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950
590409003947	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
590409003948	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
590409003949	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
590409003950	TPP-binding site [chemical binding]; other site
590409003951	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
590409003952	dimer interface [polypeptide binding]; other site
590409003953	PYR/PP interface [polypeptide binding]; other site
590409003954	TPP binding site [chemical binding]; other site
590409003955	dihydrolipoamide succinyltransferase; Validated; Region: PRK05704
590409003956	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
590409003957	E3 interaction surface; other site
590409003958	lipoyl attachment site [posttranslational modification]; other site
590409003959	e3 binding domain; Region: E3_binding; pfam02817
590409003960	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
590409003961	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
590409003962	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
590409003963	CoA-ligase; Region: Ligase_CoA; pfam00549
590409003964	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
590409003965	CoA binding domain; Region: CoA_binding; smart00881
590409003966	CoA-ligase; Region: Ligase_CoA; pfam00549
590409003967	cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097
590409003968	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562
590409003969	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
590409003970	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
590409003971	Membrane bound YbgT-like protein; Region: YbgT_YccB; pfam08173
590409003972	hypothetical protein; Provisional; Region: PRK10588
590409003973	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
590409003974	active site
590409003975	colicin uptake protein TolQ; Provisional; Region: PRK10801
590409003976	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
590409003977	colicin uptake protein TolR; Provisional; Region: PRK11024
590409003978	cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510
590409003979	TolA C-terminal; Region: TolA; pfam06519
590409003980	translocation protein TolB; Provisional; Region: tolB; PRK03629
590409003981	TolB amino-terminal domain; Region: TolB_N; pfam04052
590409003982	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
590409003983	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
590409003984	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
590409003985	peptidoglycan-associated outer membrane lipoprotein; Provisional; Region: PRK10802
590409003986	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
590409003987	ligand binding site [chemical binding]; other site
590409003988	tol-pal system protein YbgF; Provisional; Region: PRK10803
590409003989	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
590409003990	binding surface
590409003991	TPR motif; other site
590409003992	Protein of unknown function (DUF554); Region: DUF554; pfam04474
590409003993	quinolinate synthetase; Provisional; Region: PRK09375
590409003994	nicotinamide riboside transporter PnuC; Provisional; Region: PRK15397
590409003995	phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261
590409003996	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
590409003997	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
590409003998	catalytic core [active]
590409003999	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
590409004000	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
590409004001	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
590409004002	HlyD family secretion protein; Region: HlyD_3; pfam13437
590409004003	Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604
590409004004	Outer membrane efflux protein; Region: OEP; pfam02321
590409004005	Outer membrane efflux protein; Region: OEP; pfam02321
590409004006	Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604
590409004007	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
590409004008	active site
590409004009	catalytic residues [active]
590409004010	galactokinase; Provisional; Region: PRK05101
590409004011	Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509
590409004012	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
590409004013	galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720
590409004014	Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608
590409004015	dimer interface [polypeptide binding]; other site
590409004016	active site
590409004017	UDP-galactose-4-epimerase; Provisional; Region: PRK10675
590409004018	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
590409004019	NAD binding site [chemical binding]; other site
590409004020	homodimer interface [polypeptide binding]; other site
590409004021	active site
590409004022	substrate binding site [chemical binding]; other site
590409004023	putative molybdenum transport ATP-binding protein ModF; Provisional; Region: PRK10938
590409004024	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
590409004025	Walker A/P-loop; other site
590409004026	ATP binding site [chemical binding]; other site
590409004027	Q-loop/lid; other site
590409004028	ABC transporter signature motif; other site
590409004029	Walker B; other site
590409004030	D-loop; other site
590409004031	H-loop/switch region; other site
590409004032	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
590409004033	Walker A/P-loop; other site
590409004034	ATP binding site [chemical binding]; other site
590409004035	Q-loop/lid; other site
590409004036	ABC transporter signature motif; other site
590409004037	Walker B; other site
590409004038	D-loop; other site
590409004039	H-loop/switch region; other site
590409004040	DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676
590409004041	N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005
590409004042	molybdenum-pterin binding domain; Region: Mop; TIGR00638
590409004043	Protein of unknown function (DUF2592); Region: DUF2592; pfam10766
590409004044	molybdate transporter periplasmic protein; Provisional; Region: modA; PRK10677
590409004045	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
590409004046	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
590409004047	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
590409004048	dimer interface [polypeptide binding]; other site
590409004049	conserved gate region; other site
590409004050	putative PBP binding loops; other site
590409004051	ABC-ATPase subunit interface; other site
590409004052	molybdate transporter ATP-binding protein; Provisional; Region: modC; PRK11144
590409004053	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
590409004054	Walker A/P-loop; other site
590409004055	ATP binding site [chemical binding]; other site
590409004056	Q-loop/lid; other site
590409004057	ABC transporter signature motif; other site
590409004058	Walker B; other site
590409004059	D-loop; other site
590409004060	H-loop/switch region; other site
590409004061	molybdenum-pterin binding domain; Region: Mop; TIGR00638
590409004062	pyridoxal phosphate (PLP) phosphatase; Provisional; Region: PRK10530
590409004063	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
590409004064	active site
590409004065	motif I; other site
590409004066	motif II; other site
590409004067	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
590409004068	6-phosphogluconolactonase; Provisional; Region: PRK11028
590409004069	Uncharacterized conserved protein [Function unknown]; Region: COG5276
590409004070	Methylthioribose-binding protein-like of ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_methylthioribose_binding_like; cd06305
590409004071	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
590409004072	putative ligand binding site [chemical binding]; other site
590409004073	VirK protein; Region: VirK; pfam06903
590409004074	methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133
590409004075	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
590409004076	active site
590409004077	HIGH motif; other site
590409004078	KMSKS motif; other site
590409004079	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
590409004080	tRNA binding surface [nucleotide binding]; other site
590409004081	anticodon binding site; other site
590409004082	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
590409004083	dimer interface [polypeptide binding]; other site
590409004084	putative tRNA-binding site [nucleotide binding]; other site
590409004085	antiporter inner membrane protein; Provisional; Region: PRK11670
590409004086	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
590409004087	Walker A motif; other site
590409004088	Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572
590409004089	Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023
590409004090	ATP-binding site [chemical binding]; other site
590409004091	Sugar specificity; other site
590409004092	Pyrimidine base specificity; other site
590409004093	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
590409004094	trimer interface [polypeptide binding]; other site
590409004095	active site
590409004096	putative assembly protein; Provisional; Region: PRK10833
590409004097	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
590409004098	Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861
590409004099	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
590409004100	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
590409004101	Transporter associated domain; Region: CorC_HlyC; smart01091
590409004102	polysaccharide export protein Wza; Provisional; Region: PRK15078
590409004103	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
590409004104	SLBB domain; Region: SLBB; pfam10531
590409004105	Low molecular weight phosphatase family; Region: LMWPc; cd00115
590409004106	Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451
590409004107	active site
590409004108	tyrosine kinase; Provisional; Region: PRK11519
590409004109	Chain length determinant protein; Region: Wzz; pfam02706
590409004110	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
590409004111	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
590409004112	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
590409004113	This family is most closely related to the GT1 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II); Region: GT1_ExpE7_like; cd03823
590409004114	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
590409004115	This family is most closely related to the GT1 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II); Region: GT1_ExpE7_like; cd03823
590409004116	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
590409004117	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
590409004118	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
590409004119	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
590409004120	active site
590409004121	putative UDP-glucose lipid carrier transferase; Provisional; Region: PRK10124
590409004122	Bacterial sugar transferase; Region: Bac_transf; pfam02397
590409004123	dTDP-glucose 4,6 dehydratase; Provisional; Region: PRK10084
590409004124	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
590409004125	NAD binding site [chemical binding]; other site
590409004126	substrate binding site [chemical binding]; other site
590409004127	homodimer interface [polypeptide binding]; other site
590409004128	active site
590409004129	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
590409004130	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
590409004131	substrate binding site; other site
590409004132	tetramer interface; other site
590409004133	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405
590409004134	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
590409004135	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
590409004136	NADP binding site [chemical binding]; other site
590409004137	active site
590409004138	putative substrate binding site [chemical binding]; other site
590409004139	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
590409004140	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196
590409004141	Probable Catalytic site; other site
590409004142	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
590409004143	Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128
590409004144	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
590409004145	mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479
590409004146	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
590409004147	Substrate binding site; other site
590409004148	Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050
590409004149	phosphomannomutase CpsG; Provisional; Region: PRK15414
590409004150	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
590409004151	active site
590409004152	substrate binding site [chemical binding]; other site
590409004153	metal binding site [ion binding]; metal-binding site
590409004154	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
590409004155	UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253
590409004156	putative NAD(P) binding site [chemical binding]; other site
590409004157	active site
590409004158	putative substrate binding site [chemical binding]; other site
590409004159	UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057
590409004160	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
590409004161	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
590409004162	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
590409004163	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
590409004164	active site
590409004165	tetramer interface; other site
590409004166	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
590409004167	6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
590409004168	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
590409004169	Protein of unknown function (DUF2886); Region: DUF2886; pfam11102
590409004170	Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251
590409004171	Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082
590409004172	diguanylate cyclase AdrA; Provisional; Region: adrA; PRK10245
590409004173	MASE2 domain; Region: MASE2; pfam05230
590409004174	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
590409004175	metal binding site [ion binding]; metal-binding site
590409004176	active site
590409004177	I-site; other site
590409004178	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
590409004179	DNA-binding site [nucleotide binding]; DNA binding site
590409004180	Transcriptional regulators [Transcription]; Region: FadR; COG2186
590409004181	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414
590409004182	DNA-binding site [nucleotide binding]; DNA binding site
590409004183	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
590409004184	probable AcnD-accessory protein PrpF; Region: prpF; TIGR02334
590409004185	short chain dehydrogenase; Provisional; Region: PRK12937
590409004186	tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362
590409004187	NADP binding site [chemical binding]; other site
590409004188	homodimer interface [polypeptide binding]; other site
590409004189	active site
590409004190	substrate binding site [chemical binding]; other site
590409004191	Protein of unknown function (DUF535); Region: DUF535; pfam04393
590409004192	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
590409004193	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
590409004194	dimerization interface [polypeptide binding]; other site
590409004195	DPS ferroxidase diiron center [ion binding]; other site
590409004196	ion pore; other site
590409004197	AMP nucleosidase; Provisional; Region: PRK08292
590409004198	Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423
590409004199	Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775
590409004200	type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344
590409004201	type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361
590409004202	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
590409004203	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
590409004204	Uncharacterized conserved protein [Function unknown]; Region: COG4104
590409004205	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
590409004206	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
590409004207	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
590409004208	FOG: Ankyrin repeat [General function prediction only]; Region: Arp; COG0666
590409004209	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
590409004210	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
590409004211	Domain of unknown function (DUF4123); Region: DUF4123; pfam13503
590409004212	Domain of unknown function (DUF4123); Region: DUF4123; pfam13503
590409004213	RHS Repeat; Region: RHS_repeat; pfam05593
590409004214	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
590409004215	RHS Repeat; Region: RHS_repeat; pfam05593
590409004216	RHS Repeat; Region: RHS_repeat; pfam05593
590409004217	RHS Repeat; Region: RHS_repeat; pfam05593
590409004218	RHS Repeat; Region: RHS_repeat; pfam05593
590409004219	YD repeat (two copies); Region: YD_repeat_2x; TIGR01643
590409004220	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
590409004221	Protein of unknown function (DUF2750); Region: DUF2750; pfam11042
590409004222	SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346
590409004223	SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747
590409004224	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
590409004225	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666
590409004226	metal binding site [ion binding]; metal-binding site
590409004227	putative dimer interface [polypeptide binding]; other site
590409004228	Protein of unknown function (DUF770); Region: DUF770; pfam05591
590409004229	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3517
590409004230	Protein of unknown function (DUF877); Region: DUF877; pfam05943
590409004231	type VI secretion system lysozyme-like protein; Region: VI_zyme; TIGR03357
590409004232	Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3519
590409004233	type VI secretion protein, VC_A0110 family; Region: VI_chp_6; TIGR03359
590409004234	type VI secretion protein, VC_A0111 family; Region: VI_chp_1; TIGR03347
590409004235	type VI secretion system FHA domain protein; Region: VI_FHA; TIGR03354
590409004236	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062
590409004237	phosphopeptide binding site; other site
590409004238	type VI secretion lipoprotein, VC_A0113 family; Region: VI_chp_3; TIGR03352
590409004239	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3522
590409004240	Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936
590409004241	Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850
590409004242	type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345
590409004243	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
590409004244	Walker A motif; other site
590409004245	ATP binding site [chemical binding]; other site
590409004246	Walker B motif; other site
590409004247	arginine finger; other site
590409004248	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
590409004249	Walker A motif; other site
590409004250	ATP binding site [chemical binding]; other site
590409004251	Walker B motif; other site
590409004252	arginine finger; other site
590409004253	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
590409004254	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
590409004255	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
590409004256	Walker A motif; other site
590409004257	ATP binding site [chemical binding]; other site
590409004258	Walker B motif; other site
590409004259	arginine finger; other site
590409004260	Protein of unknown function (DUF3121); Region: DUF3121; cl11879
590409004261	ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812
590409004262	type VI secretion-associated protein, VC_A0119 family; Region: VI_chp_7; TIGR03362
590409004263	type VI secretion protein IcmF; Region: VI_IcmF; TIGR03348
590409004264	Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761
590409004265	Protein of unknown function (DUF1215); Region: DUF1215; pfam06744
590409004266	ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812
590409004267	ImpA domain protein; Region: DUF3702; pfam12486
590409004268	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
590409004269	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
590409004270	Sel1-like repeats; Region: SEL1; smart00671
590409004271	DKNYY family; Region: DKNYY; pfam13644
590409004272	DKNYY family; Region: DKNYY; pfam13644
590409004273	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
590409004274	D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558
590409004275	homodimer interface [polypeptide binding]; other site
590409004276	substrate-cofactor binding pocket; other site
590409004277	pyridoxal 5'-phosphate binding site [chemical binding]; other site
590409004278	catalytic residue [active]
590409004279	L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129
590409004280	L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319
590409004281	active site
590409004282	Protein of unknown function (DUF1611); Region: DUF1611; pfam07755
590409004283	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
590409004284	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
590409004285	metal binding site [ion binding]; metal-binding site
590409004286	active site
590409004287	I-site; other site
590409004288	Iron permease FTR1 family; Region: FTR1; cl00475
590409004289	inactive ferrous ion transporter periplasmic protein EfeO; Provisional; Region: PRK10378
590409004290	Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473
590409004291	Imelysin; Region: Peptidase_M75; pfam09375
590409004292	Tat-translocated enzyme; Region: tat_substr_1; TIGR01412
590409004293	Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837
590409004294	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3813
590409004295	Protein of unknown function (DUF1272); Region: DUF1272; pfam06906
590409004296	proline/glycine betaine transporter; Provisional; Region: PRK10642
590409004297	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
590409004298	putative substrate translocation pore; other site
590409004299	Osmosensory transporter coiled coil; Region: Osmo_CC; pfam08946
590409004300	Transcriptional regulator [Transcription]; Region: LysR; COG0583
590409004301	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
590409004302	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474
590409004303	putative effector binding pocket; other site
590409004304	putative dimerization interface [polypeptide binding]; other site
590409004305	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
590409004306	Old yellow enzyme (OYE)-related FMN binding domain, group 4.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735
590409004307	putative active site [active]
590409004308	putative FMN binding site [chemical binding]; other site
590409004309	putative substrate binding site [chemical binding]; other site
590409004310	putative catalytic residue [active]
590409004311	SnoaL-like domain; Region: SnoaL_3; pfam13474
590409004312	Ketosteroid isomerase homolog [Function unknown]; Region: COG4319
590409004313	cupin fold metalloprotein, WbuC family; Region: cupin_WbuC; TIGR04366
590409004314	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
590409004315	periplasmic multidrug efflux lipoprotein precursor; Reviewed; Region: PRK09578
590409004316	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
590409004317	HlyD family secretion protein; Region: HlyD_3; pfam13437
590409004318	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
590409004319	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
590409004320	active site
590409004321	phosphorylation site [posttranslational modification]
590409004322	intermolecular recognition site; other site
590409004323	dimerization interface [polypeptide binding]; other site
590409004324	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
590409004325	DNA binding site [nucleotide binding]
590409004326	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
590409004327	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
590409004328	dimerization interface [polypeptide binding]; other site
590409004329	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
590409004330	dimer interface [polypeptide binding]; other site
590409004331	phosphorylation site [posttranslational modification]
590409004332	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
590409004333	ATP binding site [chemical binding]; other site
590409004334	Mg2+ binding site [ion binding]; other site
590409004335	G-X-G motif; other site
590409004336	Transcriptional regulator [Transcription]; Region: LysR; COG0583
590409004337	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
590409004338	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421
590409004339	putative dimerization interface [polypeptide binding]; other site
590409004340	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253
590409004341	dimer interface [polypeptide binding]; other site
590409004342	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
590409004343	metal binding site [ion binding]; metal-binding site
590409004344	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
590409004345	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
590409004346	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
590409004347	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
590409004348	Uncharacterized conserved protein [Function unknown]; Region: COG1556
590409004349	iron-sulfur cluster-binding protein; Region: TIGR00273
590409004350	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
590409004351	4Fe-4S binding domain; Region: Fer4; cl02805
590409004352	Domain of unknown function (DUF3390); Region: DUF3390; pfam11870
590409004353	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
590409004354	Cysteine-rich domain; Region: CCG; pfam02754
590409004355	Cysteine-rich domain; Region: CCG; pfam02754
590409004356	cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705
590409004357	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
590409004358	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
590409004359	S-adenosylmethionine binding site [chemical binding]; other site
590409004360	Cupin domain; Region: Cupin_2; pfam07883
590409004361	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
590409004362	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
590409004363	hypothetical protein; Provisional; Region: PRK10711
590409004364	hypothetical protein; Provisional; Region: PRK01821
590409004365	Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566
590409004366	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
590409004367	active site
590409004368	phosphorylation site [posttranslational modification]
590409004369	intermolecular recognition site; other site
590409004370	dimerization interface [polypeptide binding]; other site
590409004371	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
590409004372	DNA binding residues [nucleotide binding]
590409004373	dimerization interface [polypeptide binding]; other site
590409004374	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
590409004375	dimer interface [polypeptide binding]; other site
590409004376	phosphorylation site [posttranslational modification]
590409004377	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
590409004378	ATP binding site [chemical binding]; other site
590409004379	Mg2+ binding site [ion binding]; other site
590409004380	G-X-G motif; other site
590409004381	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
590409004382	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
590409004383	Walker A/P-loop; other site
590409004384	ATP binding site [chemical binding]; other site
590409004385	Q-loop/lid; other site
590409004386	ABC transporter signature motif; other site
590409004387	Walker B; other site
590409004388	D-loop; other site
590409004389	H-loop/switch region; other site
590409004390	ABC nitrate/sulfonate/bicarbonate family transporter, ATPase subunit; Region: ABC_transp; pfam09821
590409004391	ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism]; Region: COG4986
590409004392	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
590409004393	dimer interface [polypeptide binding]; other site
590409004394	conserved gate region; other site
590409004395	putative PBP binding loops; other site
590409004396	ABC-ATPase subunit interface; other site
590409004397	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
590409004398	dimer interface [polypeptide binding]; other site
590409004399	conserved gate region; other site
590409004400	putative PBP binding loops; other site
590409004401	ABC-ATPase subunit interface; other site
590409004402	catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061
590409004403	N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649
590409004404	dimer interface [polypeptide binding]; other site
590409004405	active site
590409004406	heme binding site [chemical binding]; other site
590409004407	C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200
590409004408	peptidoglycan synthase FtsI; Provisional; Region: PRK15105
590409004409	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
590409004410	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
590409004411	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
590409004412	S-adenosylmethionine binding site [chemical binding]; other site
590409004413	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
590409004414	The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489
590409004415	substrate binding site [chemical binding]; other site
590409004416	nickel ABC transporter, permease subunit NikB; Region: nickel_nikB; TIGR02789
590409004417	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
590409004418	dimer interface [polypeptide binding]; other site
590409004419	conserved gate region; other site
590409004420	putative PBP binding loops; other site
590409004421	ABC-ATPase subunit interface; other site
590409004422	nickel transporter permease NikC; Provisional; Region: nikC; PRK10417
590409004423	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
590409004424	dimer interface [polypeptide binding]; other site
590409004425	conserved gate region; other site
590409004426	putative PBP binding loops; other site
590409004427	ABC-ATPase subunit interface; other site
590409004428	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
590409004429	nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770
590409004430	Walker A/P-loop; other site
590409004431	ATP binding site [chemical binding]; other site
590409004432	Q-loop/lid; other site
590409004433	ABC transporter signature motif; other site
590409004434	Walker B; other site
590409004435	D-loop; other site
590409004436	H-loop/switch region; other site
590409004437	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
590409004438	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
590409004439	Walker A/P-loop; other site
590409004440	ATP binding site [chemical binding]; other site
590409004441	Q-loop/lid; other site
590409004442	ABC transporter signature motif; other site
590409004443	Walker B; other site
590409004444	D-loop; other site
590409004445	H-loop/switch region; other site
590409004446	MarR family; Region: MarR_2; cl17246
590409004447	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
590409004448	multidrug efflux system protein EmrA; Provisional; Region: PRK15136
590409004449	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
590409004450	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
590409004451	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
590409004452	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
590409004453	putative substrate translocation pore; other site
590409004454	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
590409004455	right oriC-binding transcriptional activator; Provisional; Region: PRK15121
590409004456	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
590409004457	GyrI-like small molecule binding domain; Region: GyrI-like; cl01368
590409004458	hypothetical protein; Provisional; Region: PRK11667
590409004459	Flavin Reductases; Region: FlaRed; cl00801
590409004460	Domain of unknown function (DUF1971); Region: DUF1971; cl17717
590409004461	Domain of unknown function (DUF1869); Region: DUF1869; pfam08956
590409004462	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
590409004463	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
590409004464	active site
590409004465	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
590409004466	ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953
590409004467	putative NADP binding site [chemical binding]; other site
590409004468	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
590409004469	active site
590409004470	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
590409004471	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
590409004472	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
590409004473	active site
590409004474	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
590409004475	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
590409004476	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
590409004477	3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304
590409004478	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
590409004479	active site
590409004480	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
590409004481	ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953
590409004482	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
590409004483	putative NADP binding site [chemical binding]; other site
590409004484	active site
590409004485	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
590409004486	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
590409004487	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
590409004488	active site
590409004489	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
590409004490	hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466
590409004491	uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228
590409004492	putative NADP binding site [chemical binding]; other site
590409004493	putative substrate binding site [chemical binding]; other site
590409004494	active site
590409004495	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
590409004496	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
590409004497	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
590409004498	catalytic residue [active]
590409004499	Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236
590409004500	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
590409004501	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
590409004502	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
590409004503	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
590409004504	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
590409004505	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
590409004506	acyl-activating enzyme (AAE) consensus motif; other site
590409004507	AMP binding site [chemical binding]; other site
590409004508	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
590409004509	Condensation domain; Region: Condensation; pfam00668
590409004510	The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116
590409004511	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
590409004512	acyl-activating enzyme (AAE) consensus motif; other site
590409004513	AMP binding site [chemical binding]; other site
590409004514	natural product biosynthesis luciferase-like monooxygenase domain; Region: seco_metab_LLM; TIGR04020
590409004515	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
590409004516	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
590409004517	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
590409004518	Condensation domain; Region: Condensation; pfam00668
590409004519	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
590409004520	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
590409004521	acyl-activating enzyme (AAE) consensus motif; other site
590409004522	AMP binding site [chemical binding]; other site
590409004523	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
590409004524	Condensation domain; Region: Condensation; pfam00668
590409004525	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117
590409004526	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
590409004527	acyl-activating enzyme (AAE) consensus motif; other site
590409004528	AMP binding site [chemical binding]; other site
590409004529	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
590409004530	Condensation domain; Region: Condensation; pfam00668
590409004531	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
590409004532	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
590409004533	Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319
590409004534	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
590409004535	Cytochrome P450; Region: p450; cl12078
590409004536	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
590409004537	homodimer interface [polypeptide binding]; other site
590409004538	Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819
590409004539	active site
590409004540	TDP-binding site; other site
590409004541	acceptor substrate-binding pocket; other site
590409004542	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
590409004543	YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function.  YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase.   Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454
590409004544	putative active site [active]
590409004545	putative catalytic site [active]
590409004546	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_12; cd13142
590409004547	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
590409004548	2-oxoacid ferredoxin oxidoreductase; Provisional; Region: PRK13030
590409004549	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
590409004550	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
590409004551	catalytic site [active]
590409004552	Domain of unknown function (DUF4189); Region: DUF4189; pfam13827
590409004553	Transcriptional regulator [Transcription]; Region: LysR; COG0583
590409004554	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
590409004555	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
590409004556	putative effector binding pocket; other site
590409004557	dimerization interface [polypeptide binding]; other site
590409004558	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
590409004559	alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
590409004560	putative NAD(P) binding site [chemical binding]; other site
590409004561	Uncharacterized conserved protein [Function unknown]; Region: COG1359
590409004562	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242
590409004563	putative dimer interface [polypeptide binding]; other site
590409004564	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
590409004565	ligand binding site [chemical binding]; other site
590409004566	Zn binding site [ion binding]; other site
590409004567	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
590409004568	Conserved protein containing a Zn-ribbon-like motif, possibly RNA-binding [General function prediction only]; Region: COG5516
590409004569	Protein of unknown function (DUF1470); Region: DUF1470; pfam07336
590409004570	CGNR zinc finger; Region: zf-CGNR; pfam11706
590409004571	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
590409004572	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
590409004573	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3558
590409004574	SnoaL-like domain; Region: SnoaL_2; pfam12680
590409004575	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
590409004576	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
590409004577	catalytic triad [active]
590409004578	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
590409004579	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
590409004580	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
590409004581	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
590409004582	active site
590409004583	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
590409004584	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
590409004585	FMN binding site [chemical binding]; other site
590409004586	substrate binding site [chemical binding]; other site
590409004587	putative catalytic residue [active]
590409004588	Transcriptional regulator [Transcription]; Region: LysR; COG0583
590409004589	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
590409004590	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
590409004591	putative effector binding pocket; other site
590409004592	dimerization interface [polypeptide binding]; other site
590409004593	DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019
590409004594	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
590409004595	catalytic residues [active]
590409004596	hinge region; other site
590409004597	alpha helical domain; other site
590409004598	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_3; cd13148
590409004599	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
590409004600	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
590409004601	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
590409004602	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
590409004603	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
590409004604	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
590409004605	HlyD family secretion protein; Region: HlyD_3; pfam13437
590409004606	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
590409004607	short chain dehydrogenase; Provisional; Region: PRK06179
590409004608	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
590409004609	NADP binding site [chemical binding]; other site
590409004610	active site
590409004611	steroid binding site; other site
590409004612	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06333
590409004613	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
590409004614	dimer interface [polypeptide binding]; other site
590409004615	active site
590409004616	short chain dehydrogenase; Provisional; Region: PRK08263
590409004617	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
590409004618	NADP binding site [chemical binding]; other site
590409004619	active site
590409004620	steroid binding site; other site
590409004621	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
590409004622	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
590409004623	alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
590409004624	putative NAD(P) binding site [chemical binding]; other site
590409004625	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
590409004626	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
590409004627	FMN binding site [chemical binding]; other site
590409004628	active site
590409004629	substrate binding site [chemical binding]; other site
590409004630	catalytic residue [active]
590409004631	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
590409004632	classical (c) SDRs; Region: SDR_c; cd05233
590409004633	NAD(P) binding site [chemical binding]; other site
590409004634	active site
590409004635	Old yellow enzyme (OYE)-related FMN binding domain, group 5.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_5_FMN; cd04747
590409004636	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
590409004637	putative active site [active]
590409004638	putative FMN binding site [chemical binding]; other site
590409004639	putative substrate binding site [chemical binding]; other site
590409004640	putative catalytic residue [active]
590409004641	Predicted transcriptional regulators [Transcription]; Region: COG1733
590409004642	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
590409004643	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
590409004644	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
590409004645	short chain dehydrogenase; Provisional; Region: PRK06914
590409004646	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
590409004647	NADP binding site [chemical binding]; other site
590409004648	active site
590409004649	steroid binding site; other site
590409004650	SnoaL-like domain; Region: SnoaL_2; pfam12680
590409004651	YCII-related domain; Region: YCII; cl00999
590409004652	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
590409004653	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
590409004654	enoyl-CoA hydratase; Provisional; Region: PRK06563
590409004655	substrate binding site [chemical binding]; other site
590409004656	oxyanion hole (OAH) forming residues; other site
590409004657	trimer interface [polypeptide binding]; other site
590409004658	Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073
590409004659	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
590409004660	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
590409004661	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
590409004662	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
590409004663	hexamer interface [polypeptide binding]; other site
590409004664	active site 2 [active]
590409004665	Protein of unknown function (DUF2424); Region: DUF2424; pfam10340
590409004666	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
590409004667	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
590409004668	Predicted transcriptional regulators [Transcription]; Region: COG1733
590409004669	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
590409004670	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
590409004671	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
590409004672	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
590409004673	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
590409004674	NAD(P) binding site [chemical binding]; other site
590409004675	active site
590409004676	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
590409004677	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
590409004678	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
590409004679	putative DNA binding site [nucleotide binding]; other site
590409004680	dimerization interface [polypeptide binding]; other site
590409004681	putative Zn2+ binding site [ion binding]; other site
590409004682	AsnC family; Region: AsnC_trans_reg; pfam01037
590409004683	putative transposase OrfB; Reviewed; Region: PHA02517
590409004684	Integrase core domain; Region: rve; pfam00665
590409004685	Integrase core domain; Region: rve_2; pfam13333
590409004686	Lhr-like helicases [General function prediction only]; Region: Lhr; COG1201
590409004687	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
590409004688	ATP binding site [chemical binding]; other site
590409004689	putative Mg++ binding site [ion binding]; other site
590409004690	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
590409004691	nucleotide binding region [chemical binding]; other site
590409004692	ATP-binding site [chemical binding]; other site
590409004693	P-loop Domain of unknown function (DUF2791); Region: DUF2791; pfam10923
590409004694	AAA ATPase domain; Region: AAA_16; pfam13191
590409004695	Domain of unknown function (DUF4016); Region: DUF4016; pfam13208
590409004696	tellurite resistance protein terB; Region: terB; cd07176
590409004697	putative metal binding site [ion binding]; other site
590409004698	Post-segregation antitoxin CcdA; Region: CcdA; pfam07362
590409004699	CcdB protein; Region: CcdB; pfam01845
590409004700	SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747
590409004701	TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375
590409004702	TrbM; Region: TrbM; pfam07424
590409004703	P-type DNA transfer ATPase VirB11; Region: VirB11; TIGR02788
590409004704	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
590409004705	Walker A motif; other site
590409004706	ATP binding site [chemical binding]; other site
590409004707	Walker B motif; other site
590409004708	Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743
590409004709	VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911
590409004710	VirB7 interaction site; other site
590409004711	VirB8 protein; Region: VirB8; pfam04335
590409004712	TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; pfam04610
590409004713	P-type DNA transfer protein VirB5; Region: VirB5; TIGR02791
590409004714	Type IV secretion system proteins; Region: T4SS; pfam07996
590409004715	Type IV secretory pathway, VirB3-like protein; Region: VirB3; cl01501
590409004716	type IV secretion/conjugal transfer ATPase, VirB4 family; Region: VirB4_CagE; TIGR00929
590409004717	CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135
590409004718	TrbC/VIRB2 family; Region: TrbC; pfam04956
590409004719	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
590409004720	N-acetyl-D-glucosamine binding site [chemical binding]; other site
590409004721	catalytic residue [active]
590409004722	Protein of unknown function (DUF2971); Region: DUF2971; pfam11185
590409004723	phage/conjugal plasmid C-4 type zinc finger protein, TraR family; Region: C4_traR_proteo; TIGR02419
590409004724	Protein of unknown function (DUF2857); Region: DUF2857; pfam11198
590409004725	Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311
590409004726	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
590409004727	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
590409004728	non-specific DNA binding site [nucleotide binding]; other site
590409004729	salt bridge; other site
590409004730	sequence-specific DNA binding site [nucleotide binding]; other site
590409004731	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
590409004732	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
590409004733	non-specific DNA binding site [nucleotide binding]; other site
590409004734	salt bridge; other site
590409004735	sequence-specific DNA binding site [nucleotide binding]; other site
590409004736	Winged helix-turn-helix DNA-binding; Region: HTH_35; pfam13693
590409004737	type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344
590409004738	type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361
590409004739	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
590409004740	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
590409004741	Domain of unknown function (DUF1795); Region: DUF1795; pfam08786
590409004742	PAAR motif; Region: PAAR_motif; pfam05488
590409004743	RHS Repeat; Region: RHS_repeat; pfam05593
590409004744	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
590409004745	RHS Repeat; Region: RHS_repeat; pfam05593
590409004746	RHS Repeat; Region: RHS_repeat; cl11982
590409004747	RHS Repeat; Region: RHS_repeat; cl11982
590409004748	RHS Repeat; Region: RHS_repeat; pfam05593
590409004749	RHS Repeat; Region: RHS_repeat; pfam05593
590409004750	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
590409004751	Uncharacterized conserved protein [Function unknown]; Region: COG5489
590409004752	integrase; Provisional; Region: PRK09692
590409004753	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
590409004754	active site
590409004755	Int/Topo IB signature motif; other site
590409004756	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
590409004757	D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049
590409004758	hypothetical protein; Provisional; Region: PRK10613
590409004759	response regulator; Provisional; Region: PRK09483
590409004760	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
590409004761	active site
590409004762	phosphorylation site [posttranslational modification]
590409004763	intermolecular recognition site; other site
590409004764	dimerization interface [polypeptide binding]; other site
590409004765	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
590409004766	DNA binding residues [nucleotide binding]
590409004767	dimerization interface [polypeptide binding]; other site
590409004768	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
590409004769	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
590409004770	GIY-YIG motif/motif A; other site
590409004771	active site
590409004772	catalytic site [active]
590409004773	putative DNA binding site [nucleotide binding]; other site
590409004774	metal binding site [ion binding]; metal-binding site
590409004775	UvrB/uvrC motif; Region: UVR; pfam02151
590409004776	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
590409004777	phosphatidylglycerophosphate synthetase; Provisional; Region: PRK10832
590409004778	phage lysis regulatory protein, LysB family; Region: phage_LysB; TIGR03495
590409004779	The lysozyme from bacteriophage lambda hydrolyses the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc), as do other lysozymes.  But unlike other lysozymes, bacteriophage lambda does not produce a reducing...; Region: bacteriophage_lambda_lysozyme; cd00736
590409004780	N-acetyl-D-glucosamine binding site [chemical binding]; other site
590409004781	catalytic residue [active]
590409004782	Phage holin family 2; Region: Phage_holin_2; pfam04550
590409004783	Right handed beta helix region; Region: Beta_helix; pfam13229
590409004784	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150
590409004785	Cellulose-binding domain, chitinase and related proteins; Region: CBD_like; cd12204
590409004786	aromatic chitin/cellulose binding site residues [chemical binding]; other site
590409004787	ligand binding site [chemical binding]; other site
590409004788	Cytochrome b562; Region: Cytochrom_B562; cl01546
590409004789	MATE family multidrug exporter; Provisional; Region: PRK10189
590409004790	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137
590409004791	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262
590409004792	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
590409004793	hypothetical protein; Provisional; Region: PRK10708
590409004794	ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181
590409004795	dimer interface [polypeptide binding]; other site
590409004796	ligand binding site [chemical binding]; other site
590409004797	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
590409004798	dimerization interface [polypeptide binding]; other site
590409004799	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
590409004800	dimer interface [polypeptide binding]; other site
590409004801	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
590409004802	putative CheW interface [polypeptide binding]; other site
590409004803	transcriptional activator FlhD; Provisional; Region: PRK02909
590409004804	transcriptional activator FlhC; Provisional; Region: PRK12722
590409004805	Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291
590409004806	flagellar motor protein MotA; Validated; Region: PRK09110
590409004807	flagellar motor protein MotB; Reviewed; Region: motB; PRK12799
590409004808	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
590409004809	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
590409004810	ligand binding site [chemical binding]; other site
590409004811	chemotaxis protein CheA; Provisional; Region: PRK10547
590409004812	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
590409004813	putative binding surface; other site
590409004814	active site
590409004815	CheY binding; Region: CheY-binding; pfam09078
590409004816	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
590409004817	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
590409004818	ATP binding site [chemical binding]; other site
590409004819	Mg2+ binding site [ion binding]; other site
590409004820	G-X-G motif; other site
590409004821	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
590409004822	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
590409004823	putative CheA interaction surface; other site
590409004824	methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041
590409004825	ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181
590409004826	dimer interface [polypeptide binding]; other site
590409004827	ligand binding site [chemical binding]; other site
590409004828	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
590409004829	dimerization interface [polypeptide binding]; other site
590409004830	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
590409004831	dimer interface [polypeptide binding]; other site
590409004832	putative CheW interface [polypeptide binding]; other site
590409004833	chemotaxis methyltransferase CheR; Provisional; Region: PRK10611
590409004834	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
590409004835	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
590409004836	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
590409004837	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
590409004838	active site
590409004839	phosphorylation site [posttranslational modification]
590409004840	intermolecular recognition site; other site
590409004841	dimerization interface [polypeptide binding]; other site
590409004842	CheB methylesterase; Region: CheB_methylest; pfam01339
590409004843	chemotaxis regulatory protein CheY; Provisional; Region: PRK10610
590409004844	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
590409004845	active site
590409004846	phosphorylation site [posttranslational modification]
590409004847	intermolecular recognition site; other site
590409004848	dimerization interface [polypeptide binding]; other site
590409004849	chemotaxis regulator CheZ; Provisional; Region: PRK11166
590409004850	flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702
590409004851	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257
590409004852	flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012
590409004853	FHIPEP family; Region: FHIPEP; pfam00771
590409004854	Flagellar protein FlhE; Region: FlhE; pfam06366
590409004855	FlgN protein; Region: FlgN; cl09176
590409004856	anti-sigma28 factor FlgM; Provisional; Region: PRK10810
590409004857	flagellar basal body P-ring biosynthesis protein FlgA; Reviewed; Region: flgA; PRK07018
590409004858	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
590409004859	Domains similar to fish antifreeze type III protein; Region: SAF; cl00555
590409004860	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680
590409004861	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182
590409004862	flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681
590409004863	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
590409004864	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
590409004865	flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655
590409004866	Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963
590409004867	FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861
590409004868	flagellar hook protein FlgE; Validated; Region: flgE; PRK05682
590409004869	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
590409004870	Flagellar basal body protein FlaE; Region: FlaE; pfam07559
590409004871	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
590409004872	flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640
590409004873	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
590409004874	flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490
590409004875	flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693
590409004876	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
590409004877	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
590409004878	Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063
590409004879	flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249
590409004880	flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303
590409004881	flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622
590409004882	flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684
590409004883	Rod binding protein [Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3951
590409004884	Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705
590409004885	flagellar hook-associated protein FlgK; Region: flgK_ends; TIGR02492
590409004886	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
590409004887	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
590409004888	flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08027
590409004889	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
590409004890	flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701
590409004891	flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700
590409004892	flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699
590409004893	Flagellar biosynthesis protein, FliO; Region: FliO; pfam04347
590409004894	flagellar motor switch protein FliN; Validated; Region: fliN; PRK07963
590409004895	flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666
590409004896	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
590409004897	flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07021
590409004898	Flagellar hook-length control protein FliK; Region: Flg_hook; cl17777
590409004899	flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689
590409004900	Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882
590409004901	flagellum-specific ATP synthase; Validated; Region: fliI; PRK07960
590409004902	Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136
590409004903	Walker A motif/ATP binding site; other site
590409004904	Walker B motif; other site
590409004905	flagellar assembly protein H; Validated; Region: fliH; PRK05687
590409004906	Essential protein Yae1, N terminal; Region: Yae1_N; pfam09811
590409004907	Flagellar assembly protein FliH; Region: FliH; pfam02108
590409004908	flagellar motor switch protein G; Validated; Region: fliG; PRK05686
590409004909	FliG C-terminal domain; Region: FliG_C; pfam01706
590409004910	flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007
590409004911	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514
590409004912	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
590409004913	flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00253
590409004914	Flagellar protein FliT; Region: FliT; cl05125
590409004915	flagellar protein FliS; Validated; Region: fliS; PRK05685
590409004916	flagellar capping protein; Reviewed; Region: fliD; PRK08032
590409004917	Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465
590409004918	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
590409004919	flagellin; Provisional; Region: PRK12802
590409004920	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
590409004921	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
590409004922	Methyltransferase domain; Region: Methyltransf_31; pfam13847
590409004923	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
590409004924	S-adenosylmethionine binding site [chemical binding]; other site
590409004925	Predicted methyltransferase regulatory domain; Region: MethyTransf_Reg; pfam10119
590409004926	Predicted regulatory domain of a methyltransferase [General function prediction only]; Region: COG4797
590409004927	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
590409004928	binding surface
590409004929	TPR motif; other site
590409004930	TPR repeat; Region: TPR_11; pfam13414
590409004931	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
590409004932	binding surface
590409004933	TPR motif; other site
590409004934	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
590409004935	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
590409004936	inhibitor-cofactor binding pocket; inhibition site
590409004937	pyridoxal 5'-phosphate binding site [chemical binding]; other site
590409004938	catalytic residue [active]
590409004939	ATP-grasp domain; Region: ATP-grasp_4; cl17255
590409004940	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
590409004941	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
590409004942	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
590409004943	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
590409004944	flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986
590409004945	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
590409004946	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
590409004947	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
590409004948	DNA binding residues [nucleotide binding]
590409004949	flagella biosynthesis protein FliZ; Provisional; Region: PRK11582
590409004950	hypothetical protein; Provisional; Region: PRK10536
590409004951	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
590409004952	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
590409004953	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
590409004954	dimer interface [polypeptide binding]; other site
590409004955	putative CheW interface [polypeptide binding]; other site
590409004956	hypothetical protein; Provisional; Region: PRK09273
590409004957	Ribose 5-phosphate isomerase RpiB [Carbohydrate transport and metabolism]; Region: RpiB; COG0698
590409004958	Ribose-5-phosphate isomerase; Region: DUF3666; pfam12408
590409004959	FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287
590409004960	active site 1 [active]
590409004961	dimer interface [polypeptide binding]; other site
590409004962	active site 2 [active]
590409004963	Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067
590409004964	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
590409004965	Ter macrodomain organizer matS-binding protein; Provisional; Region: PRK05097
590409004966	Protein of unknown function (DUF2566); Region: DUF2566; pfam10753
590409004967	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
590409004968	HAMP domain; Region: HAMP; pfam00672
590409004969	dimerization interface [polypeptide binding]; other site
590409004970	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
590409004971	dimer interface [polypeptide binding]; other site
590409004972	putative CheW interface [polypeptide binding]; other site
590409004973	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
590409004974	PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172
590409004975	glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274
590409004976	Periplasmic glucan biosynthesis protein, MdoG; Region: MdoG; cl15433
590409004977	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
590409004978	Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191
590409004979	Ligand binding site; other site
590409004980	DXD motif; other site
590409004981	drug efflux system protein MdtG; Provisional; Region: PRK09874
590409004982	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
590409004983	putative substrate translocation pore; other site
590409004984	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
590409004985	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
590409004986	putative acyl-acceptor binding pocket; other site
590409004987	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
590409004988	Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis.  Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932
590409004989	active site
590409004990	FMN binding site [chemical binding]; other site
590409004991	substrate binding site [chemical binding]; other site
590409004992	homotetramer interface [polypeptide binding]; other site
590409004993	catalytic residue [active]
590409004994	putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142
590409004995	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
590409004996	active site residue [active]
590409004997	hypothetical protein; Provisional; Region: PRK03757
590409004998	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
590409004999	biofilm formation regulatory protein BssS; Reviewed; Region: bssS; PRK12301
590409005000	DNA damage-inducible protein I; Provisional; Region: PRK10597
590409005001	Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294
590409005002	active site
590409005003	substrate binding pocket [chemical binding]; other site
590409005004	dimer interface [polypeptide binding]; other site
590409005005	Uncharacterized conserved protein [Function unknown]; Region: COG1359
590409005006	ribonuclease E; Reviewed; Region: rne; PRK10811
590409005007	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
590409005008	homodimer interface [polypeptide binding]; other site
590409005009	oligonucleotide binding site [chemical binding]; other site
590409005010	Polyribonucleotide phosphorylase C terminal; Region: PNPase_C; pfam12111
590409005011	23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025
590409005012	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
590409005013	RNA binding surface [nucleotide binding]; other site
590409005014	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
590409005015	active site
590409005016	Maf-like protein; Region: Maf; pfam02545
590409005017	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
590409005018	active site
590409005019	dimer interface [polypeptide binding]; other site
590409005020	hypothetical protein; Provisional; Region: PRK11193
590409005021	50S ribosomal protein L32; Validated; Region: rpmF; PRK01110
590409005022	putative phosphate acyltransferase; Provisional; Region: PRK05331
590409005023	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
590409005024	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
590409005025	dimer interface [polypeptide binding]; other site
590409005026	active site
590409005027	CoA binding pocket [chemical binding]; other site
590409005028	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
590409005029	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
590409005030	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
590409005031	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
590409005032	NAD(P) binding site [chemical binding]; other site
590409005033	homotetramer interface [polypeptide binding]; other site
590409005034	homodimer interface [polypeptide binding]; other site
590409005035	active site
590409005036	acyl carrier protein; Provisional; Region: acpP; PRK00982
590409005037	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314
590409005038	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
590409005039	dimer interface [polypeptide binding]; other site
590409005040	active site
590409005041	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
590409005042	ADCL_like: 4-Amino-4-deoxychorismate lyase:  is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate.  Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559
590409005043	pyridoxal 5'-phosphate binding site [chemical binding]; other site
590409005044	catalytic residue [active]
590409005045	YceG-like family; Region: YceG; pfam02618
590409005046	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
590409005047	dimerization interface [polypeptide binding]; other site
590409005048	thymidylate kinase; Validated; Region: tmk; PRK00698
590409005049	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
590409005050	TMP-binding site; other site
590409005051	ATP-binding site [chemical binding]; other site
590409005052	DNA polymerase III subunit delta'; Validated; Region: PRK07993
590409005053	DNA polymerase III subunit delta'; Validated; Region: PRK08485
590409005054	DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115
590409005055	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
590409005056	active site
590409005057	PTS system glucose-specific transporter subunits IIBC; Provisional; Region: PRK11089
590409005058	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
590409005059	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
590409005060	active site turn [active]
590409005061	phosphorylation site [posttranslational modification]
590409005062	Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900
590409005063	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
590409005064	nucleotide binding site/active site [active]
590409005065	HIT family signature motif; other site
590409005066	catalytic residue [active]
590409005067	Predicted periplasmic lipoprotein [General function prediction only]; Region: COG5633
590409005068	Putative periplasmic lipoprotein; Region: DUF1425; cd09030
590409005069	putative dimer interface [polypeptide binding]; other site
590409005070	Collagen-binding surface adhesin SpaP (antigen I/II family) [General function prediction only]; Region: FlgN; COG3417
590409005071	thiamine kinase; Region: ycfN_thiK; TIGR02721
590409005072	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
590409005073	active site
590409005074	substrate binding site [chemical binding]; other site
590409005075	ATP binding site [chemical binding]; other site
590409005076	beta-hexosaminidase; Provisional; Region: PRK05337
590409005077	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
590409005078	hypothetical protein; Provisional; Region: PRK04940
590409005079	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
590409005080	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
590409005081	hypothetical protein; Provisional; Region: PRK11280
590409005082	Transcriptional regulators [Transcription]; Region: PurR; COG1609
590409005083	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
590409005084	DNA binding site [nucleotide binding]
590409005085	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
590409005086	ligand binding site [chemical binding]; other site
590409005087	dimerization interface [polypeptide binding]; other site
590409005088	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
590409005089	D-galactonate transporter; Region: 2A0114; TIGR00893
590409005090	putative substrate translocation pore; other site
590409005091	Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501
590409005092	Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802
590409005093	Glycosyl hydrolase family 31 (GH31) domain of a bacterial protein family represented by Escherichia coli protein Aec37. The gene encoding Aec37 (aec-37) is located within a genomic island (AGI-3) isolated from the extraintestinal avian pathogenic...; Region: GH31_glycosidase_Aec37; cd06599
590409005094	putative active site [active]
590409005095	putative catalytic site [active]
590409005096	N-acetyltransferase; Region: Acetyltransf_2; pfam00797
590409005097	putative chaperone; Provisional; Region: PRK11678
590409005098	Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231
590409005099	nucleotide binding site [chemical binding]; other site
590409005100	putative NEF/HSP70 interaction site [polypeptide binding]; other site
590409005101	SBD interface [polypeptide binding]; other site
590409005102	phage resistance protein; Provisional; Region: PRK10551
590409005103	CSS motif domain associated with EAL; Region: CSS-motif; pfam12792
590409005104	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
590409005105	transcription-repair coupling factor; Provisional; Region: PRK10689
590409005106	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
590409005107	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
590409005108	ATP binding site [chemical binding]; other site
590409005109	putative Mg++ binding site [ion binding]; other site
590409005110	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
590409005111	nucleotide binding region [chemical binding]; other site
590409005112	ATP-binding site [chemical binding]; other site
590409005113	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
590409005114	outer membrane-specific lipoprotein transporter subunit LolC; Provisional; Region: PRK10814
590409005115	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
590409005116	FtsX-like permease family; Region: FtsX; pfam02687
590409005117	lipoprotein transporter ATP-binding subunit; Provisional; Region: lolD; PRK11629
590409005118	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
590409005119	Walker A/P-loop; other site
590409005120	ATP binding site [chemical binding]; other site
590409005121	Q-loop/lid; other site
590409005122	ABC transporter signature motif; other site
590409005123	Walker B; other site
590409005124	D-loop; other site
590409005125	H-loop/switch region; other site
590409005126	outer membrane-specific lipoprotein transporter subunit LolE; Provisional; Region: PRK11146
590409005127	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
590409005128	FtsX-like permease family; Region: FtsX; pfam02687
590409005129	fructokinase; Reviewed; Region: PRK09557
590409005130	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
590409005131	nucleotide binding site [chemical binding]; other site
590409005132	NAD-dependent deacetylase; Provisional; Region: PRK00481
590409005133	SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412
590409005134	NAD+ binding site [chemical binding]; other site
590409005135	substrate binding site [chemical binding]; other site
590409005136	Zn binding site [ion binding]; other site
590409005137	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
590409005138	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
590409005139	ABC-ATPase subunit  interface; other site
590409005140	dimer interface [polypeptide binding]; other site
590409005141	putative PBP binding regions; other site
590409005142	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
590409005143	catalytic residues [active]
590409005144	dimer interface [polypeptide binding]; other site
590409005145	vitamin B12-transporter ATPase; Provisional; Region: PRK03695
590409005146	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
590409005147	Walker A/P-loop; other site
590409005148	ATP binding site [chemical binding]; other site
590409005149	Q-loop/lid; other site
590409005150	ABC transporter signature motif; other site
590409005151	Walker B; other site
590409005152	D-loop; other site
590409005153	H-loop/switch region; other site
590409005154	NlpC/P60 family; Region: NLPC_P60; pfam00877
590409005155	lipoate-protein ligase A; Provisional; Region: lplA; PRK03822
590409005156	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
590409005157	Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437
590409005158	EAL domain; Region: EAL; pfam00563
590409005159	hypothetical protein; Validated; Region: PRK00029
590409005160	Uncharacterized conserved protein [Function unknown]; Region: COG0397
590409005161	murein L,D-transpeptidase; Provisional; Region: PRK10594
590409005162	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
590409005163	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
590409005164	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
590409005165	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108
590409005166	Peptidase M15; Region: Peptidase_M15_3; cl01194
590409005167	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
590409005168	aromatic amino acid aminotransferase; Provisional; Region: PRK09257
590409005169	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
590409005170	pyridoxal 5'-phosphate binding site [chemical binding]; other site
590409005171	homodimer interface [polypeptide binding]; other site
590409005172	catalytic residue [active]
590409005173	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
590409005174	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
590409005175	trimer interface [polypeptide binding]; other site
590409005176	eyelet of channel; other site
590409005177	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
590409005178	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
590409005179	eyelet of channel; other site
590409005180	trimer interface [polypeptide binding]; other site
590409005181	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
590409005182	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
590409005183	trimer interface [polypeptide binding]; other site
590409005184	eyelet of channel; other site
590409005185	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
590409005186	EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318
590409005187	putative dimer interface [polypeptide binding]; other site
590409005188	putative anticodon binding site; other site
590409005189	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
590409005190	homodimer interface [polypeptide binding]; other site
590409005191	motif 1; other site
590409005192	motif 2; other site
590409005193	active site
590409005194	motif 3; other site
590409005195	nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514
590409005196	Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401
590409005197	active site
590409005198	aminopeptidase N; Provisional; Region: pepN; PRK14015
590409005199	Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600
590409005200	active site
590409005201	Zn binding site [ion binding]; other site
590409005202	aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247
590409005203	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
590409005204	Walker A/P-loop; other site
590409005205	ATP binding site [chemical binding]; other site
590409005206	Q-loop/lid; other site
590409005207	ABC transporter signature motif; other site
590409005208	Walker B; other site
590409005209	D-loop; other site
590409005210	H-loop/switch region; other site
590409005211	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
590409005212	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
590409005213	dimer interface [polypeptide binding]; other site
590409005214	conserved gate region; other site
590409005215	putative PBP binding loops; other site
590409005216	ABC-ATPase subunit interface; other site
590409005217	alkanesulfonate monooxygenase; Provisional; Region: PRK00719
590409005218	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
590409005219	active site
590409005220	dimer interface [polypeptide binding]; other site
590409005221	non-prolyl cis peptide bond; other site
590409005222	insertion regions; other site
590409005223	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
590409005224	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
590409005225	substrate binding pocket [chemical binding]; other site
590409005226	membrane-bound complex binding site; other site
590409005227	hinge residues; other site
590409005228	NAD(P)H-dependent FMN reductase; Provisional; Region: PRK10569
590409005229	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
590409005230	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
590409005231	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
590409005232	quinone interaction residues [chemical binding]; other site
590409005233	active site
590409005234	catalytic residues [active]
590409005235	FMN binding site [chemical binding]; other site
590409005236	substrate binding site [chemical binding]; other site
590409005237	Protein of unknown function (DUF1379); Region: DUF1379; pfam07126
590409005238	Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217
590409005239	MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476
590409005240	MOSC domain; Region: MOSC; pfam03473
590409005241	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
590409005242	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
590409005243	catalytic loop [active]
590409005244	iron binding site [ion binding]; other site
590409005245	23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783
590409005246	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
590409005247	Putative RNA methylase family UPF0020; Region: UPF0020; pfam01170
590409005248	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
590409005249	S-adenosylmethionine binding site [chemical binding]; other site
590409005250	ABC transporter ATPase component; Reviewed; Region: PRK11147
590409005251	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
590409005252	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
590409005253	Walker A/P-loop; other site
590409005254	ATP binding site [chemical binding]; other site
590409005255	Q-loop/lid; other site
590409005256	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
590409005257	ABC transporter signature motif; other site
590409005258	Walker B; other site
590409005259	D-loop; other site
590409005260	ABC transporter; Region: ABC_tran_2; pfam12848
590409005261	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
590409005262	paraquat-inducible membrane protein A; Provisional; Region: PRK15103
590409005263	Paraquat-inducible protein A; Region: PqiA; pfam04403
590409005264	Paraquat-inducible protein A; Region: PqiA; pfam04403
590409005265	paraquat-inducible protein B; Provisional; Region: PRK10807
590409005266	mce related protein; Region: MCE; pfam02470
590409005267	mce related protein; Region: MCE; pfam02470
590409005268	mce related protein; Region: MCE; pfam02470
590409005269	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009
590409005270	Protein of unknown function (DUF330); Region: DUF330; pfam03886
590409005271	Ribosome modulation factor; Region: RMF; pfam04957
590409005272	phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12756
590409005273	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
590409005274	PEP synthetase regulatory protein; Provisional; Region: PRK05339
590409005275	phosphoenolpyruvate synthase; Validated; Region: PRK06464
590409005276	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
590409005277	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
590409005278	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
590409005279	putative inner membrane protein; Provisional; Region: PRK10983
590409005280	Domain of unknown function DUF20; Region: UPF0118; pfam01594
590409005281	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
590409005282	FAD binding domain; Region: FAD_binding_4; pfam01565
590409005283	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
590409005284	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
590409005285	CoenzymeA binding site [chemical binding]; other site
590409005286	subunit interaction site [polypeptide binding]; other site
590409005287	PHB binding site; other site
590409005288	L,D-transpeptidase; Provisional; Region: PRK10190
590409005289	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
590409005290	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
590409005291	murein lipoprotein; Provisional; Region: PRK15396
590409005292	pyruvate kinase; Provisional; Region: PRK09206
590409005293	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288
590409005294	domain interfaces; other site
590409005295	active site
590409005296	transcriptional antiterminator BglG; Provisional; Region: PRK09772
590409005297	CAT RNA binding domain; Region: CAT_RBD; pfam03123
590409005298	PRD domain; Region: PRD; pfam00874
590409005299	PRD domain; Region: PRD; pfam00874
590409005300	PTS system beta-glucoside-specific transporter subunits IIABC; Provisional; Region: PRK09824
590409005301	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
590409005302	active site turn [active]
590409005303	phosphorylation site [posttranslational modification]
590409005304	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
590409005305	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210
590409005306	HPr interaction site; other site
590409005307	glycerol kinase (GK) interaction site [polypeptide binding]; other site
590409005308	active site
590409005309	phosphorylation site [posttranslational modification]
590409005310	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046
590409005311	beta-galactosidase; Region: BGL; TIGR03356
590409005312	N-terminal Early set domain associated with the catalytic domain of putative esterases; Region: E_set_Esterase_like_N; cd11294
590409005313	Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382
590409005314	LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025
590409005315	dimer interface [polypeptide binding]; other site
590409005316	catalytic triad [active]
590409005317	multidrug efflux protein; Reviewed; Region: PRK01766
590409005318	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131
590409005319	cation binding site [ion binding]; other site
590409005320	riboflavin synthase subunit alpha; Provisional; Region: PRK13020
590409005321	Lumazine binding domain; Region: Lum_binding; pfam00677
590409005322	Lumazine binding domain; Region: Lum_binding; pfam00677
590409005323	cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705
590409005324	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
590409005325	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
590409005326	S-adenosylmethionine binding site [chemical binding]; other site
590409005327	lycopene cyclase; Region: lycopene_cycl; TIGR01789
590409005328	DNA-binding transcriptional repressor PurR; Provisional; Region: PRK10703
590409005329	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
590409005330	DNA binding site [nucleotide binding]
590409005331	domain linker motif; other site
590409005332	Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275
590409005333	dimerization interface [polypeptide binding]; other site
590409005334	ligand binding site [chemical binding]; other site
590409005335	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
590409005336	NlpC/P60 family; Region: NLPC_P60; pfam00877
590409005337	Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028
590409005338	putative GSH binding site [chemical binding]; other site
590409005339	catalytic residues [active]
590409005340	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
590409005341	DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134
590409005342	dimer interface [polypeptide binding]; other site
590409005343	catalytic site [active]
590409005344	putative active site [active]
590409005345	putative substrate binding site [chemical binding]; other site
590409005346	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
590409005347	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
590409005348	dimer interface [polypeptide binding]; other site
590409005349	active site
590409005350	metal binding site [ion binding]; metal-binding site
590409005351	glutathione binding site [chemical binding]; other site
590409005352	Predicted Fe-S protein [General function prediction only]; Region: COG3313
590409005353	transcriptional regulator SlyA; Provisional; Region: PRK03573
590409005354	MarR family; Region: MarR; pfam01047
590409005355	Outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: SlyB; COG3133
590409005356	anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585
590409005357	Predicted periplasmic protein [General function prediction only]; Region: COG3895
590409005358	Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864
590409005359	pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679
590409005360	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
590409005361	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
590409005362	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
590409005363	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
590409005364	active site
590409005365	HIGH motif; other site
590409005366	dimer interface [polypeptide binding]; other site
590409005367	KMSKS motif; other site
590409005368	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
590409005369	RNA binding surface [nucleotide binding]; other site
590409005370	pyridoxamine kinase; Validated; Region: PRK05756
590409005371	Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate  (PLP), by catalyzing the phosphorylation of the precursor vitamin B6  in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173
590409005372	dimer interface [polypeptide binding]; other site
590409005373	pyridoxal binding site [chemical binding]; other site
590409005374	ATP binding site [chemical binding]; other site
590409005375	glutathionine S-transferase; Provisional; Region: PRK10542
590409005376	GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057
590409005377	C-terminal domain interface [polypeptide binding]; other site
590409005378	GSH binding site (G-site) [chemical binding]; other site
590409005379	dimer interface [polypeptide binding]; other site
590409005380	C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188
590409005381	N-terminal domain interface [polypeptide binding]; other site
590409005382	dimer interface [polypeptide binding]; other site
590409005383	substrate binding pocket (H-site) [chemical binding]; other site
590409005384	aconitate hydratase; Validated; Region: PRK09277
590409005385	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
590409005386	substrate binding site [chemical binding]; other site
590409005387	ligand binding site [chemical binding]; other site
590409005388	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
590409005389	substrate binding site [chemical binding]; other site
590409005390	oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104
590409005391	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
590409005392	peptide binding site [polypeptide binding]; other site
590409005393	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
590409005394	dimerization interface [polypeptide binding]; other site
590409005395	active site
590409005396	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
590409005397	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610
590409005398	active site
590409005399	Predicted membrane protein [Function unknown]; Region: COG3771
590409005400	tetratricopeptide repeat protein; Provisional; Region: PRK11788
590409005401	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
590409005402	TPR motif; other site
590409005403	binding surface
590409005404	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
590409005405	active site
590409005406	dimer interface [polypeptide binding]; other site
590409005407	translation initiation factor Sui1; Validated; Region: PRK06824
590409005408	Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567
590409005409	putative rRNA binding site [nucleotide binding]; other site
590409005410	lipoprotein; Provisional; Region: PRK10540
590409005411	L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193
590409005412	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398
590409005413	intersubunit interface [polypeptide binding]; other site
590409005414	active site
590409005415	Zn2+ binding site [ion binding]; other site
590409005416	2-keto-3-deoxygluconate transporter; Region: kdgT; TIGR00793
590409005417	carbon starvation protein A; Provisional; Region: PRK15015
590409005418	Carbon starvation protein CstA; Region: CstA; pfam02554
590409005419	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
590409005420	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
590409005421	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
590409005422	active site
590409005423	catalytic tetrad [active]
590409005424	exoribonuclease II; Provisional; Region: PRK05054
590409005425	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
590409005426	RNB domain; Region: RNB; pfam00773
590409005427	S1 RNA binding domain; Region: S1; pfam00575
590409005428	Predicted membrane protein (DUF2335); Region: DUF2335; cl02210
590409005429	oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701
590409005430	The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767
590409005431	putative molybdopterin cofactor binding site [chemical binding]; other site
590409005432	The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787
590409005433	putative molybdopterin cofactor binding site; other site
590409005434	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
590409005435	Transcriptional regulator [Transcription]; Region: LysR; COG0583
590409005436	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
590409005437	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
590409005438	dimerization interface [polypeptide binding]; other site
590409005439	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
590409005440	Coenzyme A binding pocket [chemical binding]; other site
590409005441	Homeodomain-like domain; Region: HTH_23; pfam13384
590409005442	Winged helix-turn helix; Region: HTH_29; pfam13551
590409005443	Homeodomain-like domain; Region: HTH_32; pfam13565
590409005444	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07984
590409005445	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
590409005446	NAD binding site [chemical binding]; other site
590409005447	homotetramer interface [polypeptide binding]; other site
590409005448	homodimer interface [polypeptide binding]; other site
590409005449	substrate binding site [chemical binding]; other site
590409005450	active site
590409005451	antimicrobial peptide ABC system ATP-binding protein SapF; Provisional; Region: PRK15112
590409005452	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
590409005453	Walker A/P-loop; other site
590409005454	ATP binding site [chemical binding]; other site
590409005455	Q-loop/lid; other site
590409005456	ABC transporter signature motif; other site
590409005457	Walker B; other site
590409005458	D-loop; other site
590409005459	H-loop/switch region; other site
590409005460	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
590409005461	antimicrobial peptide ABC transporter ATP-binding protein; Provisional; Region: PRK15093
590409005462	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
590409005463	Walker A/P-loop; other site
590409005464	ATP binding site [chemical binding]; other site
590409005465	Q-loop/lid; other site
590409005466	ABC transporter signature motif; other site
590409005467	Walker B; other site
590409005468	D-loop; other site
590409005469	H-loop/switch region; other site
590409005470	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
590409005471	antimicrobial peptide ABC transporter permease SapC; Provisional; Region: PRK15111
590409005472	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
590409005473	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
590409005474	dimer interface [polypeptide binding]; other site
590409005475	conserved gate region; other site
590409005476	ABC-ATPase subunit interface; other site
590409005477	antimicrobial peptide ABC transporter permease SapB; Provisional; Region: PRK15110
590409005478	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
590409005479	dimer interface [polypeptide binding]; other site
590409005480	conserved gate region; other site
590409005481	putative PBP binding loops; other site
590409005482	ABC-ATPase subunit interface; other site
590409005483	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
590409005484	The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493
590409005485	peptide binding site [polypeptide binding]; other site
590409005486	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
590409005487	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
590409005488	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
590409005489	phage shock protein operon transcriptional activator; Provisional; Region: pspF; PRK11608
590409005490	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
590409005491	Walker A motif; other site
590409005492	ATP binding site [chemical binding]; other site
590409005493	Walker B motif; other site
590409005494	arginine finger; other site
590409005495	phage shock protein PspA; Provisional; Region: PRK10698
590409005496	phage shock protein B; Provisional; Region: pspB; PRK09458
590409005497	DNA-binding transcriptional activator PspC; Provisional; Region: PRK10697
590409005498	phage shock protein C; Region: phageshock_pspC; TIGR02978
590409005499	Predicted ATPase [General function prediction only]; Region: COG3106
590409005500	hypothetical protein; Provisional; Region: PRK05415
590409005501	Domain of unknown function (DUF697); Region: DUF697; cl12064
590409005502	benzoate transport; Region: 2A0115; TIGR00895
590409005503	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
590409005504	putative substrate translocation pore; other site
590409005505	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
590409005506	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
590409005507	hypothetical protein; Provisional; Region: PRK06446
590409005508	metal binding site [ion binding]; metal-binding site
590409005509	DNA-binding transcriptional regulator TyrR; Provisional; Region: PRK10820
590409005510	N-terminal ACT domain of the TyrR protein; Region: ACT_TyrR; cd04877
590409005511	putative aromatic amino acid binding site; other site
590409005512	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
590409005513	putative active site [active]
590409005514	heme pocket [chemical binding]; other site
590409005515	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
590409005516	Walker A motif; other site
590409005517	ATP binding site [chemical binding]; other site
590409005518	Walker B motif; other site
590409005519	arginine finger; other site
590409005520	Transcriptional regulator [Transcription]; Region: LysR; COG0583
590409005521	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
590409005522	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472
590409005523	putative effector binding pocket; other site
590409005524	putative dimerization interface [polypeptide binding]; other site
590409005525	hypothetical protein; Provisional; Region: PRK08204
590409005526	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
590409005527	active site
590409005528	Protein of unknown function, DUF606; Region: DUF606; pfam04657
590409005529	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
590409005530	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
590409005531	active site
590409005532	catalytic tetrad [active]
590409005533	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
590409005534	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
590409005535	Protein related to penicillin acylase [General function prediction only]; Region: COG2366
590409005536	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
590409005537	Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747
590409005538	active site
590409005539	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
590409005540	salt bridge; other site
590409005541	non-specific DNA binding site [nucleotide binding]; other site
590409005542	sequence-specific DNA binding site [nucleotide binding]; other site
590409005543	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
590409005544	putative substrate translocation pore; other site
590409005545	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
590409005546	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
590409005547	dimer interface [polypeptide binding]; other site
590409005548	catalytic triad [active]
590409005549	peroxidatic and resolving cysteines [active]
590409005550	murein peptide amidase A; Provisional; Region: PRK10602
590409005551	active site
590409005552	Zn binding site [ion binding]; other site
590409005553	oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104
590409005554	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
590409005555	peptide binding site [polypeptide binding]; other site
590409005556	Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833
590409005557	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
590409005558	Cl binding site [ion binding]; other site
590409005559	oligomer interface [polypeptide binding]; other site
590409005560	tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696
590409005561	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_II; cd01993
590409005562	Ligand Binding Site [chemical binding]; other site
590409005563	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832
590409005564	Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139
590409005565	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
590409005566	dimerization interface [polypeptide binding]; other site
590409005567	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
590409005568	dimer interface [polypeptide binding]; other site
590409005569	putative CheW interface [polypeptide binding]; other site
590409005570	Domain of unknown function (DUF333); Region: DUF333; pfam03891
590409005571	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
590409005572	D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183
590409005573	putative ligand binding site [chemical binding]; other site
590409005574	putative NAD binding site [chemical binding]; other site
590409005575	catalytic site [active]
590409005576	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
590409005577	PAS fold; Region: PAS_3; pfam08447
590409005578	putative active site [active]
590409005579	heme pocket [chemical binding]; other site
590409005580	HAMP domain; Region: HAMP; pfam00672
590409005581	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
590409005582	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
590409005583	dimer interface [polypeptide binding]; other site
590409005584	putative CheW interface [polypeptide binding]; other site
590409005585	hypothetical protein; Provisional; Region: PRK10695
590409005586	YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617
590409005587	Acyltransferase family; Region: Acyl_transf_3; pfam01757
590409005588	azoreductase; Reviewed; Region: PRK00170
590409005589	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
590409005590	ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131
590409005591	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
590409005592	ATP binding site [chemical binding]; other site
590409005593	putative Mg++ binding site [ion binding]; other site
590409005594	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
590409005595	nucleotide binding region [chemical binding]; other site
590409005596	ATP-binding site [chemical binding]; other site
590409005597	Helicase associated domain (HA2); Region: HA2; pfam04408
590409005598	Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717
590409005599	Domain of unknown function (DUF3418); Region: DUF3418; pfam11898
590409005600	Uncharacterized conserved protein [Function unknown]; Region: COG1556
590409005601	iron-sulfur cluster-binding protein; Region: TIGR00273
590409005602	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
590409005603	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
590409005604	Domain of unknown function (DUF3390); Region: DUF3390; pfam11870
590409005605	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
590409005606	Cysteine-rich domain; Region: CCG; pfam02754
590409005607	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
590409005608	Cysteine-rich domain; Region: CCG; pfam02754
590409005609	L-lactate permease [Energy production and conversion]; Region: LldP; COG1620
590409005610	L-lactate permease; Region: Lactate_perm; cl00701
590409005611	V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591
590409005612	sensor protein RstB; Provisional; Region: PRK10604
590409005613	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
590409005614	dimerization interface [polypeptide binding]; other site
590409005615	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
590409005616	dimer interface [polypeptide binding]; other site
590409005617	phosphorylation site [posttranslational modification]
590409005618	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
590409005619	ATP binding site [chemical binding]; other site
590409005620	G-X-G motif; other site
590409005621	DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701
590409005622	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
590409005623	active site
590409005624	phosphorylation site [posttranslational modification]
590409005625	intermolecular recognition site; other site
590409005626	dimerization interface [polypeptide binding]; other site
590409005627	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
590409005628	DNA binding site [nucleotide binding]
590409005629	putative transporter; Provisional; Region: PRK11660
590409005630	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
590409005631	Sulfate transporter family; Region: Sulfate_transp; pfam00916
590409005632	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
590409005633	calcium/sodium:proton antiporter; Provisional; Region: PRK10599
590409005634	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
590409005635	Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703
590409005636	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
590409005637	putative active site pocket [active]
590409005638	dimerization interface [polypeptide binding]; other site
590409005639	putative catalytic residue [active]
590409005640	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
590409005641	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
590409005642	dimer interface [polypeptide binding]; other site
590409005643	conserved gate region; other site
590409005644	putative PBP binding loops; other site
590409005645	ABC-ATPase subunit interface; other site
590409005646	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
590409005647	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
590409005648	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
590409005649	dimer interface [polypeptide binding]; other site
590409005650	conserved gate region; other site
590409005651	ABC-ATPase subunit interface; other site
590409005652	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
590409005653	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
590409005654	Walker A/P-loop; other site
590409005655	ATP binding site [chemical binding]; other site
590409005656	Q-loop/lid; other site
590409005657	ABC transporter signature motif; other site
590409005658	Walker B; other site
590409005659	D-loop; other site
590409005660	H-loop/switch region; other site
590409005661	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
590409005662	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
590409005663	Walker A/P-loop; other site
590409005664	ATP binding site [chemical binding]; other site
590409005665	Q-loop/lid; other site
590409005666	ABC transporter signature motif; other site
590409005667	Walker B; other site
590409005668	D-loop; other site
590409005669	H-loop/switch region; other site
590409005670	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
590409005671	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512
590409005672	Putative ClC chloride channel.  Clc proteins are putative halogen ion (Cl-, Br- and I-) transporters found in eubacteria. They belong to the ClC superfamily of halogen ion channels, which share a unique double-barreled architecture and voltage-dependent...; Region: ClC_like; cd01033
590409005673	putative ion selectivity filter; other site
590409005674	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
590409005675	putative pore gating glutamate residue; other site
590409005676	PrpA and PrpB, metallophosphatase domain; Region: MPP_PrpA_PrpB; cd07424
590409005677	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
590409005678	active site
590409005679	metal binding site [ion binding]; metal-binding site
590409005680	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
590409005681	PAS domain; Region: PAS_9; pfam13426
590409005682	putative active site [active]
590409005683	heme pocket [chemical binding]; other site
590409005684	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
590409005685	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
590409005686	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
590409005687	dimer interface [polypeptide binding]; other site
590409005688	putative CheW interface [polypeptide binding]; other site
590409005689	Alginate Lyase A1-III; enzymatically depolymerizes alginate, a complex copolymer of beta-D-mannuronate and alpha-L-guluronate, by cleaving the beta-(1,4) glycosidic bond; Region: AlgLyase; cl00179
590409005690	methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041
590409005691	ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181
590409005692	dimer interface [polypeptide binding]; other site
590409005693	ligand binding site [chemical binding]; other site
590409005694	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
590409005695	dimerization interface [polypeptide binding]; other site
590409005696	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
590409005697	dimer interface [polypeptide binding]; other site
590409005698	putative CheW interface [polypeptide binding]; other site
590409005699	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
590409005700	GAF domain; Region: GAF; pfam01590
590409005701	PAS domain S-box; Region: sensory_box; TIGR00229
590409005702	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
590409005703	putative active site [active]
590409005704	heme pocket [chemical binding]; other site
590409005705	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
590409005706	PAS domain; Region: PAS_9; pfam13426
590409005707	putative active site [active]
590409005708	heme pocket [chemical binding]; other site
590409005709	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
590409005710	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
590409005711	metal binding site [ion binding]; metal-binding site
590409005712	active site
590409005713	I-site; other site
590409005714	guanine deaminase; Provisional; Region: PRK09228
590409005715	Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303
590409005716	active site
590409005717	Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606
590409005718	Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796
590409005719	Phage P2 GpU; Region: Phage_P2_GpU; pfam06995
590409005720	Phage P2 GpE; Region: Phage_P2_GpE; pfam06528
590409005721	Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109
590409005722	major tail tube protein; Provisional; Region: FII; PHA02600
590409005723	major tail sheath protein; Provisional; Region: FI; PHA02560
590409005724	Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413
590409005725	Phage Tail Collar Domain; Region: Collar; pfam07484
590409005726	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
590409005727	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
590409005728	catalytic residues [active]
590409005729	catalytic nucleophile [active]
590409005730	Presynaptic Site I dimer interface [polypeptide binding]; other site
590409005731	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
590409005732	Synaptic Flat tetramer interface [polypeptide binding]; other site
590409005733	Synaptic Site I dimer interface [polypeptide binding]; other site
590409005734	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
590409005735	DNA-binding interface [nucleotide binding]; DNA binding site
590409005736	Phage Tail Collar Domain; Region: Collar; pfam07484
590409005737	Esterase-like activity of phytase; Region: Phytase-like; pfam13449
590409005738	SdiA-regulated; Region: SdiA-regulated; cd09971
590409005739	putative active site [active]
590409005740	benzoate transport; Region: 2A0115; TIGR00895
590409005741	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
590409005742	putative substrate translocation pore; other site
590409005743	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
590409005744	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840
590409005745	Smr domain; Region: Smr; pfam01713
590409005746	Phage tail-collar fibre protein; Region: DUF3751; pfam12571
590409005747	Phage Tail Collar Domain; Region: Collar; pfam07484
590409005748	Bacteriophage P2-related tail formation protein [General function prediction only]; Region: gpI; COG4385
590409005749	baseplate assembly protein; Provisional; Region: J; PHA02568
590409005750	Gene 25-like lysozyme; Region: GPW_gp25; cl01403
590409005751	phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644
590409005752	Phage P2 baseplate assembly protein gpV [General function prediction only]; Region: gpV; COG4540
590409005753	P2 phage tail completion protein R (GpR); Region: P2_Phage_GpR; pfam06891
590409005754	Phage Tail Protein X; Region: Phage_tail_X; pfam05489
590409005755	Bacteriophage replication gene A protein (GPA); Region: Phage_GPA; pfam05840
590409005756	DksA-like zinc finger domain containing protein; Region: PHA00080
590409005757	Protein of unknown function (DUF2732); Region: DUF2732; pfam10809
590409005758	Bacteriophage CI repressor helix-turn-helix domain; Region: Phage_CI_repr; pfam07022
590409005759	Bacteriophage CI repressor helix-turn-helix domain; Region: Phage_CI_repr; pfam07022
590409005760	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
590409005761	dimerization interface [polypeptide binding]; other site
590409005762	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
590409005763	dimer interface [polypeptide binding]; other site
590409005764	putative CheW interface [polypeptide binding]; other site
590409005765	Protein of unknown function (DUF1482); Region: DUF1482; pfam07358
590409005766	rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933
590409005767	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
590409005768	S-adenosylmethionine binding site [chemical binding]; other site
590409005769	pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636
590409005770	Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008
590409005771	mce related protein; Region: MCE; pfam02470
590409005772	mce related protein; Region: MCE; pfam02470
590409005773	mce related protein; Region: MCE; pfam02470
590409005774	mce related protein; Region: MCE; pfam02470
590409005775	mce related protein; Region: MCE; pfam02470
590409005776	mce related protein; Region: MCE; pfam02470
590409005777	Uncharacterized paraquat-inducible protein A [Function unknown]; Region: PqiA; COG2995
590409005778	Paraquat-inducible protein A; Region: PqiA; pfam04403
590409005779	Paraquat-inducible protein A; Region: PqiA; pfam04403
590409005780	GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956
590409005781	ProP expression regulator; Provisional; Region: PRK04950
590409005782	ProQ/FINO family; Region: ProQ; pfam04352
590409005783	carboxy-terminal protease; Provisional; Region: PRK11186
590409005784	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
590409005785	protein binding site [polypeptide binding]; other site
590409005786	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
590409005787	Catalytic dyad [active]
590409005788	C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818
590409005789	Protein of unknown function, DUF481; Region: DUF481; pfam04338
590409005790	Acyltransferase family; Region: Acyl_transf_3; pfam01757
590409005791	transcriptional regulator NarL; Provisional; Region: PRK10651
590409005792	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
590409005793	active site
590409005794	phosphorylation site [posttranslational modification]
590409005795	intermolecular recognition site; other site
590409005796	dimerization interface [polypeptide binding]; other site
590409005797	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
590409005798	DNA binding residues [nucleotide binding]
590409005799	dimerization interface [polypeptide binding]; other site
590409005800	nitrate/nitrite sensor protein NarX; Provisional; Region: PRK10600
590409005801	Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675
590409005802	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
590409005803	dimerization interface [polypeptide binding]; other site
590409005804	Histidine kinase; Region: HisKA_3; pfam07730
590409005805	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
590409005806	ATP binding site [chemical binding]; other site
590409005807	Mg2+ binding site [ion binding]; other site
590409005808	G-X-G motif; other site
590409005809	nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034
590409005810	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
590409005811	Transcriptional regulator [Transcription]; Region: LysR; COG0583
590409005812	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
590409005813	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
590409005814	putative effector binding pocket; other site
590409005815	dimerization interface [polypeptide binding]; other site
590409005816	Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013
590409005817	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750
590409005818	[4Fe-4S] binding site [ion binding]; other site
590409005819	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
590409005820	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
590409005821	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
590409005822	Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776
590409005823	molybdopterin cofactor binding site; other site
590409005824	Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140
590409005825	Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958
590409005826	respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351
590409005827	putative alcohol dehydrogenase; Provisional; Region: PRK09860
590409005828	Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176
590409005829	dimer interface [polypeptide binding]; other site
590409005830	active site
590409005831	metal binding site [ion binding]; metal-binding site
590409005832	High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376
590409005833	Predicted transcriptional regulators [Transcription]; Region: COG1733
590409005834	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
590409005835	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
590409005836	active site 1 [active]
590409005837	dimer interface [polypeptide binding]; other site
590409005838	hexamer interface [polypeptide binding]; other site
590409005839	active site 2 [active]
590409005840	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
590409005841	catalytic residues [active]
590409005842	dimer interface [polypeptide binding]; other site
590409005843	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
590409005844	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
590409005845	hypothetical protein; Provisional; Region: PRK07206
590409005846	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
590409005847	hypothetical protein; Provisional; Region: PRK05849
590409005848	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
590409005849	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
590409005850	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
590409005851	catalytic triad [active]
590409005852	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
590409005853	Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523
590409005854	active site
590409005855	metal-binding site
590409005856	Transcriptional regulators [Transcription]; Region: PurR; COG1609
590409005857	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
590409005858	DNA binding site [nucleotide binding]
590409005859	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
590409005860	ligand binding site [chemical binding]; other site
590409005861	dimerization interface [polypeptide binding]; other site
590409005862	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
590409005863	D-galactonate transporter; Region: 2A0114; TIGR00893
590409005864	putative substrate translocation pore; other site
590409005865	PA14 domain; Region: PA14; cl08459
590409005866	Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470
590409005867	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
590409005868	GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047
590409005869	putative C-terminal domain interface [polypeptide binding]; other site
590409005870	putative GSH binding site (G-site) [chemical binding]; other site
590409005871	putative dimer interface [polypeptide binding]; other site
590409005872	C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180
590409005873	putative N-terminal domain interface [polypeptide binding]; other site
590409005874	putative dimer interface [polypeptide binding]; other site
590409005875	putative substrate binding pocket (H-site) [chemical binding]; other site
590409005876	methionine synthase; Provisional; Region: PRK01207
590409005877	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
590409005878	substrate binding site [chemical binding]; other site
590409005879	THF binding site; other site
590409005880	zinc-binding site [ion binding]; other site
590409005881	Domain of unknown function (DUF1852); Region: DUF1852; pfam08908
590409005882	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
590409005883	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
590409005884	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
590409005885	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
590409005886	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
590409005887	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
590409005888	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
590409005889	ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300
590409005890	Walker A/P-loop; other site
590409005891	ATP binding site [chemical binding]; other site
590409005892	Q-loop/lid; other site
590409005893	ABC transporter signature motif; other site
590409005894	Walker B; other site
590409005895	D-loop; other site
590409005896	H-loop/switch region; other site
590409005897	TOBE domain; Region: TOBE_2; pfam08402
590409005898	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
590409005899	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
590409005900	DNA-binding site [nucleotide binding]; DNA binding site
590409005901	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
590409005902	pyridoxal 5'-phosphate binding site [chemical binding]; other site
590409005903	homodimer interface [polypeptide binding]; other site
590409005904	catalytic residue [active]
590409005905	4-aminobutyrate aminotransferase; Provisional; Region: PRK06777
590409005906	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
590409005907	inhibitor-cofactor binding pocket; inhibition site
590409005908	pyridoxal 5'-phosphate binding site [chemical binding]; other site
590409005909	catalytic residue [active]
590409005910	succinic semialdehyde dehydrogenase; Region: PLN02278
590409005911	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
590409005912	tetramerization interface [polypeptide binding]; other site
590409005913	NAD(P) binding site [chemical binding]; other site
590409005914	catalytic residues [active]
590409005915	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
590409005916	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
590409005917	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
590409005918	dimer interface [polypeptide binding]; other site
590409005919	conserved gate region; other site
590409005920	putative PBP binding loops; other site
590409005921	ABC-ATPase subunit interface; other site
590409005922	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
590409005923	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
590409005924	dimer interface [polypeptide binding]; other site
590409005925	conserved gate region; other site
590409005926	putative PBP binding loops; other site
590409005927	ABC-ATPase subunit interface; other site
590409005928	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
590409005929	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
590409005930	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
590409005931	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
590409005932	Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate,  or similar substrates; Region: Bacterial_IMPase_like_1; cd01641
590409005933	active site
590409005934	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
590409005935	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
590409005936	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_13; cd08517
590409005937	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
590409005938	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
590409005939	dimer interface [polypeptide binding]; other site
590409005940	conserved gate region; other site
590409005941	putative PBP binding loops; other site
590409005942	ABC-ATPase subunit interface; other site
590409005943	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
590409005944	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
590409005945	dimer interface [polypeptide binding]; other site
590409005946	conserved gate region; other site
590409005947	putative PBP binding loops; other site
590409005948	ABC-ATPase subunit interface; other site
590409005949	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
590409005950	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
590409005951	Walker A/P-loop; other site
590409005952	ATP binding site [chemical binding]; other site
590409005953	Q-loop/lid; other site
590409005954	ABC transporter signature motif; other site
590409005955	Walker B; other site
590409005956	D-loop; other site
590409005957	H-loop/switch region; other site
590409005958	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
590409005959	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
590409005960	Walker A/P-loop; other site
590409005961	ATP binding site [chemical binding]; other site
590409005962	Q-loop/lid; other site
590409005963	ABC transporter signature motif; other site
590409005964	Walker B; other site
590409005965	D-loop; other site
590409005966	H-loop/switch region; other site
590409005967	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
590409005968	short chain dehydrogenase; Provisional; Region: PRK08339
590409005969	putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344
590409005970	putative NAD(P) binding site [chemical binding]; other site
590409005971	putative active site [active]
590409005972	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
590409005973	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666
590409005974	metal binding site [ion binding]; metal-binding site
590409005975	putative dimer interface [polypeptide binding]; other site
590409005976	D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711
590409005977	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
590409005978	hydroxyglutarate oxidase; Provisional; Region: PRK11728
590409005979	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
590409005980	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
590409005981	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
590409005982	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
590409005983	dimer interface [polypeptide binding]; other site
590409005984	active site
590409005985	catalytic residue [active]
590409005986	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
590409005987	PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224
590409005988	homodimer interface [polypeptide binding]; other site
590409005989	substrate-cofactor binding pocket; other site
590409005990	pyridoxal 5'-phosphate binding site [chemical binding]; other site
590409005991	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
590409005992	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
590409005993	Walker A/P-loop; other site
590409005994	ATP binding site [chemical binding]; other site
590409005995	Q-loop/lid; other site
590409005996	ABC transporter signature motif; other site
590409005997	Walker B; other site
590409005998	D-loop; other site
590409005999	H-loop/switch region; other site
590409006000	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
590409006001	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
590409006002	dimer interface [polypeptide binding]; other site
590409006003	conserved gate region; other site
590409006004	putative PBP binding loops; other site
590409006005	ABC-ATPase subunit interface; other site
590409006006	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
590409006007	dimer interface [polypeptide binding]; other site
590409006008	conserved gate region; other site
590409006009	putative PBP binding loops; other site
590409006010	ABC-ATPase subunit interface; other site
590409006011	Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053
590409006012	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
590409006013	homodimer interface [polypeptide binding]; other site
590409006014	substrate-cofactor binding pocket; other site
590409006015	pyridoxal 5'-phosphate binding site [chemical binding]; other site
590409006016	catalytic residue [active]
590409006017	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
590409006018	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
590409006019	dimer interface [polypeptide binding]; other site
590409006020	pyridoxal 5'-phosphate binding site [chemical binding]; other site
590409006021	catalytic residue [active]
590409006022	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream.   The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609
590409006023	FOG: CBS domain [General function prediction only]; Region: COG0517
590409006024	MmgE/PrpD family; Region: MmgE_PrpD; cl00912
590409006025	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
590409006026	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
590409006027	substrate binding pocket [chemical binding]; other site
590409006028	membrane-bound complex binding site; other site
590409006029	hinge residues; other site
590409006030	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
590409006031	dimerization interface [polypeptide binding]; other site
590409006032	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
590409006033	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
590409006034	dimer interface [polypeptide binding]; other site
590409006035	putative CheW interface [polypeptide binding]; other site
590409006036	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
590409006037	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
590409006038	dimerization interface [polypeptide binding]; other site
590409006039	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
590409006040	dimer interface [polypeptide binding]; other site
590409006041	putative CheW interface [polypeptide binding]; other site
590409006042	microcin B17 transporter; Reviewed; Region: PRK11098
590409006043	type III secretion protein, YscU/HrpY family; Region: FlhB_rel_III; TIGR01404
590409006044	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822
590409006045	Bacterial export proteins, family 1; Region: Bac_export_1; pfam01311
590409006046	Bacterial export proteins, family 3; Region: Bac_export_3; cl00867
590409006047	type III secretion system protein YscR; Provisional; Region: PRK12797
590409006048	type III secretion system apparatus protein YscQ/HrcQ; Region: SpaO_YscQ; TIGR02551
590409006049	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
590409006050	type III secretion apparatus H+-transporting two-sector ATPase; Region: III_secr_ATP; TIGR02546
590409006051	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
590409006052	Walker A motif; other site
590409006053	ATP binding site [chemical binding]; other site
590409006054	Walker B motif; other site
590409006055	type III secretion apparatus protein, YscD/HrpQ family; Region: type_III_yscD; TIGR02500
590409006056	FHA domain; Region: FHA; pfam00498
590409006057	phosphopeptide binding site; other site
590409006058	type III secretion protein, HrcV family; Region: hrcV; TIGR01399
590409006059	FHIPEP family; Region: FHIPEP; pfam00771
590409006060	HrpJ-like domain; Region: HrpJ; cl15454
590409006061	TyeA; Region: TyeA; cl07611
590409006062	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
590409006063	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
590409006064	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
590409006065	DNA binding residues [nucleotide binding]
590409006066	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
590409006067	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
590409006068	putative active site [active]
590409006069	heme pocket [chemical binding]; other site
590409006070	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
590409006071	putative active site [active]
590409006072	heme pocket [chemical binding]; other site
590409006073	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
590409006074	Histidine kinase; Region: HisKA_3; pfam07730
590409006075	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
590409006076	ATP binding site [chemical binding]; other site
590409006077	Mg2+ binding site [ion binding]; other site
590409006078	G-X-G motif; other site
590409006079	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
590409006080	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
590409006081	active site
590409006082	phosphorylation site [posttranslational modification]
590409006083	intermolecular recognition site; other site
590409006084	dimerization interface [polypeptide binding]; other site
590409006085	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
590409006086	DNA binding residues [nucleotide binding]
590409006087	dimerization interface [polypeptide binding]; other site
590409006088	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
590409006089	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
590409006090	Walker A motif; other site
590409006091	ATP binding site [chemical binding]; other site
590409006092	Walker B motif; other site
590409006093	arginine finger; other site
590409006094	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
590409006095	Type III secretion needle MxiH like; Region: MxiH; pfam09392
590409006096	type III secretion apparatus lipoprotein, YscJ/HrcJ family; Region: III_secr_YscJ; TIGR02544
590409006097	HrpE/YscL/FliH and V-type ATPase subunit E; Region: HrpE; pfam06188
590409006098	ATP synthase archaeal, H subunit; Region: AhaH; TIGR02926
590409006099	Transglycosylase SLT domain; Region: SLT_2; pfam13406
590409006100	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
590409006101	N-acetyl-D-glucosamine binding site [chemical binding]; other site
590409006102	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
590409006103	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
590409006104	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
590409006105	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
590409006106	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
590409006107	HrpF protein; Region: HrpF; pfam06266
590409006108	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
590409006109	pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519
590409006110	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
590409006111	HrpZ; Region: Hairpins; pfam04877
590409006112	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
590409006113	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
590409006114	Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865
590409006115	haemagglutination activity domain; Region: Haemagg_act; pfam05860
590409006116	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
590409006117	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
590409006118	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
590409006119	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
590409006120	Toxin SymE, type I toxin-antitoxin system; Region: SymE_toxin; cl07446
590409006121	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
590409006122	ParB-like nuclease domain; Region: ParB; smart00470
590409006123	RelB antitoxin; Region: RelB; cl01171
590409006124	Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668
590409006125	FeoA domain; Region: FeoA; pfam04023
590409006126	Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918
590409006127	ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554
590409006128	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
590409006129	G1 box; other site
590409006130	GTP/Mg2+ binding site [chemical binding]; other site
590409006131	Switch I region; other site
590409006132	G2 box; other site
590409006133	G3 box; other site
590409006134	Switch II region; other site
590409006135	G4 box; other site
590409006136	G5 box; other site
590409006137	Nucleoside recognition; Region: Gate; pfam07670
590409006138	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
590409006139	Nucleoside recognition; Region: Gate; pfam07670
590409006140	FeoC like transcriptional regulator; Region: FeoC; pfam09012
590409006141	Di- and tripeptidases [Amino acid transport and metabolism]; Region: PepD; COG2195
590409006142	M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892
590409006143	metal binding site [ion binding]; metal-binding site
590409006144	dimer interface [polypeptide binding]; other site
590409006145	Uncharacterized conserved protein [Function unknown]; Region: COG2850
590409006146	sensor protein PhoQ; Provisional; Region: PRK10815
590409006147	PhoQ Sensor; Region: PhoQ_Sensor; pfam08918
590409006148	His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512
590409006149	dimer interface [polypeptide binding]; other site
590409006150	phosphorylation site [posttranslational modification]
590409006151	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
590409006152	ATP binding site [chemical binding]; other site
590409006153	Mg2+ binding site [ion binding]; other site
590409006154	G-X-G motif; other site
590409006155	DNA-binding transcriptional regulator PhoP; Provisional; Region: PRK10816
590409006156	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
590409006157	active site
590409006158	phosphorylation site [posttranslational modification]
590409006159	intermolecular recognition site; other site
590409006160	dimerization interface [polypeptide binding]; other site
590409006161	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
590409006162	DNA binding site [nucleotide binding]
590409006163	adenylosuccinate lyase; Provisional; Region: PRK09285
590409006164	PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598
590409006165	tetramer interface [polypeptide binding]; other site
590409006166	active site
590409006167	putative lysogenization regulator; Reviewed; Region: PRK00218
590409006168	tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054
590409006169	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
590409006170	Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675
590409006171	nudix motif; other site
590409006172	23S rRNA pseudouridine synthase E; Provisional; Region: PRK11394
590409006173	Pseudouridine synthase, Escherichia coli RluE; Region: PseudoU_synth_RluE; cd02566
590409006174	probable active site [active]
590409006175	isocitrate dehydrogenase; Validated; Region: PRK07362
590409006176	isocitrate dehydrogenase; Reviewed; Region: PRK07006
590409006177	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
590409006178	GAF domain; Region: GAF; pfam01590
590409006179	PAS domain S-box; Region: sensory_box; TIGR00229
590409006180	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
590409006181	putative active site [active]
590409006182	heme pocket [chemical binding]; other site
590409006183	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
590409006184	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
590409006185	metal binding site [ion binding]; metal-binding site
590409006186	active site
590409006187	I-site; other site
590409006188	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
590409006189	heat shock protein HtpX; Provisional; Region: PRK05457
590409006190	Transposase IS200 like; Region: Y1_Tnp; pfam01797
590409006191	Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823
590409006192	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
590409006193	DNA-binding transcriptional regulator KdgR; Provisional; Region: PRK15090
590409006194	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
590409006195	dimerization interface [polypeptide binding]; other site
590409006196	putative Zn2+ binding site [ion binding]; other site
590409006197	putative DNA binding site [nucleotide binding]; other site
590409006198	Bacterial transcriptional regulator; Region: IclR; pfam01614
590409006199	YebO-like protein; Region: YebO; pfam13974
590409006200	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
590409006201	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
590409006202	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973
590409006203	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
590409006204	active site
590409006205	dimer interface [polypeptide binding]; other site
590409006206	motif 1; other site
590409006207	motif 2; other site
590409006208	motif 3; other site
590409006209	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
590409006210	anticodon binding site; other site
590409006211	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
590409006212	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
590409006213	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
590409006214	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
590409006215	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
590409006216	23S rRNA binding site [nucleotide binding]; other site
590409006217	L21 binding site [polypeptide binding]; other site
590409006218	L13 binding site [polypeptide binding]; other site
590409006219	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
590409006220	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
590409006221	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
590409006222	dimer interface [polypeptide binding]; other site
590409006223	motif 1; other site
590409006224	active site
590409006225	motif 2; other site
590409006226	motif 3; other site
590409006227	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
590409006228	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
590409006229	putative tRNA-binding site [nucleotide binding]; other site
590409006230	B3/4 domain; Region: B3_4; pfam03483
590409006231	tRNA synthetase B5 domain; Region: B5; smart00874
590409006232	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
590409006233	dimer interface [polypeptide binding]; other site
590409006234	motif 1; other site
590409006235	motif 3; other site
590409006236	motif 2; other site
590409006237	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
590409006238	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
590409006239	IHF dimer interface [polypeptide binding]; other site
590409006240	IHF - DNA interface [nucleotide binding]; other site
590409006241	Nitrous oxide-stimulated promoter; Region: YgbA_NO; cl08119
590409006242	aromatic amino acid exporter; Provisional; Region: PRK11689
590409006243	EamA-like transporter family; Region: EamA; cl17759
590409006244	NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171
590409006245	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
590409006246	homodimer interface [polypeptide binding]; other site
590409006247	NAD binding pocket [chemical binding]; other site
590409006248	ATP binding pocket [chemical binding]; other site
590409006249	Mg binding site [ion binding]; other site
590409006250	active-site loop [active]
590409006251	DNA-binding transcriptional activator OsmE; Provisional; Region: PRK11251
590409006252	Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823
590409006253	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
590409006254	inner membrane protein; Provisional; Region: PRK11648
590409006255	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
590409006256	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
590409006257	Oligogalacturonate-specific porin protein (KdgM); Region: KdgM; cl11629
590409006258	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
590409006259	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
590409006260	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
590409006261	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
590409006262	Walker A/P-loop; other site
590409006263	ATP binding site [chemical binding]; other site
590409006264	Q-loop/lid; other site
590409006265	ABC transporter signature motif; other site
590409006266	Walker B; other site
590409006267	D-loop; other site
590409006268	H-loop/switch region; other site
590409006269	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
590409006270	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
590409006271	dimer interface [polypeptide binding]; other site
590409006272	conserved gate region; other site
590409006273	putative PBP binding loops; other site
590409006274	ABC-ATPase subunit interface; other site
590409006275	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
590409006276	dimer interface [polypeptide binding]; other site
590409006277	conserved gate region; other site
590409006278	putative PBP binding loops; other site
590409006279	ABC-ATPase subunit interface; other site
590409006280	Periplasmic pectate lyase; Region: Pectate_lyase_2; pfam06917
590409006281	2-deoxy-D-gluconate 3-dehydrogenase; Validated; Region: PRK08993
590409006282	gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347
590409006283	NADP binding site [chemical binding]; other site
590409006284	homodimer interface [polypeptide binding]; other site
590409006285	active site
590409006286	5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924
590409006287	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
590409006288	YniB-like protein; Region: YniB; pfam14002
590409006289	Phosphotransferase enzyme family; Region: APH; pfam01636
590409006290	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
590409006291	active site
590409006292	ATP binding site [chemical binding]; other site
590409006293	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
590409006294	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
590409006295	DNA-binding site [nucleotide binding]; DNA binding site
590409006296	RNA-binding motif; other site
590409006297	23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088
590409006298	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
590409006299	S-adenosylmethionine binding site [chemical binding]; other site
590409006300	hypothetical protein; Provisional; Region: PRK11469
590409006301	Domain of unknown function DUF; Region: DUF204; pfam02659
590409006302	Domain of unknown function DUF; Region: DUF204; pfam02659
590409006303	hypothetical protein; Provisional; Region: PRK02913
590409006304	PTS system mannose-specific transporter subunit IID; Provisional; Region: PRK11103
590409006305	PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065
590409006306	PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088
590409006307	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
590409006308	active pocket/dimerization site; other site
590409006309	active site
590409006310	phosphorylation site [posttranslational modification]
590409006311	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
590409006312	active site
590409006313	phosphorylation site [posttranslational modification]
590409006314	Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861
590409006315	FOG: CBS domain [General function prediction only]; Region: COG0517
590409006316	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
590409006317	Transporter associated domain; Region: CorC_HlyC; smart01091
590409006318	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
590409006319	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
590409006320	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
590409006321	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
590409006322	putative active site [active]
590409006323	putative CoA binding site [chemical binding]; other site
590409006324	nudix motif; other site
590409006325	metal binding site [ion binding]; metal-binding site
590409006326	aminodeoxychorismate synthase subunit I; Provisional; Region: pabB; PRK15465
590409006327	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
590409006328	chorismate binding enzyme; Region: Chorismate_bind; cl10555
590409006329	hypothetical protein; Provisional; Region: PRK05114
590409006330	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cl10015
590409006331	homotrimer interaction site [polypeptide binding]; other site
590409006332	putative active site [active]
590409006333	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
590409006334	DEAD/DEAH box helicase; Region: DEAD; pfam00270
590409006335	DEAD_2; Region: DEAD_2; pfam06733
590409006336	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
590409006337	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
590409006338	Glycoprotease family; Region: Peptidase_M22; pfam00814
590409006339	Starvation-inducible outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: Slp; COG3065
590409006340	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974
590409006341	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
590409006342	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
590409006343	acyl-activating enzyme (AAE) consensus motif; other site
590409006344	putative AMP binding site [chemical binding]; other site
590409006345	putative active site [active]
590409006346	putative CoA binding site [chemical binding]; other site
590409006347	ribonuclease D; Provisional; Region: PRK10829
590409006348	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
590409006349	catalytic site [active]
590409006350	putative active site [active]
590409006351	putative substrate binding site [chemical binding]; other site
590409006352	HRDC domain; Region: HRDC; pfam00570
590409006353	cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296
590409006354	cell division inhibitor MinD; Provisional; Region: PRK10818
590409006355	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
590409006356	Switch I; other site
590409006357	Switch II; other site
590409006358	septum formation inhibitor; Reviewed; Region: minC; PRK03511
590409006359	Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209
590409006360	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
590409006361	YcgL domain; Region: YcgL; pfam05166
590409006362	hypothetical protein; Provisional; Region: PRK10691
590409006363	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
590409006364	hypothetical protein; Provisional; Region: PRK05170
590409006365	disulfide bond formation protein B; Provisional; Region: PRK01749
590409006366	fatty acid metabolism regulator; Provisional; Region: PRK04984
590409006367	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
590409006368	DNA-binding site [nucleotide binding]; DNA binding site
590409006369	FadR C-terminal domain; Region: FadR_C; pfam07840
590409006370	SpoVR family protein; Provisional; Region: PRK11767
590409006371	Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719
590409006372	D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711
590409006373	hydroxyglutarate oxidase; Provisional; Region: PRK11728
590409006374	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
590409006375	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
590409006376	C factor cell-cell signaling protein; Provisional; Region: PRK09009
590409006377	NAD(P) binding site [chemical binding]; other site
590409006378	active site
590409006379	Pectate lyase; Region: Pectate_lyase; pfam03211
590409006380	Pathogenicity factor; Region: AvrE; pfam11725
590409006381	Tir chaperone protein (CesT) family; Region: CesT; pfam05932
590409006382	exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450
590409006383	exonuclease V subunit gamma; Provisional; Region: recC; PRK11069
590409006384	exonuclease V subunit beta; Provisional; Region: recB; PRK10876
590409006385	Part of AAA domain; Region: AAA_19; pfam13245
590409006386	Family description; Region: UvrD_C_2; pfam13538
590409006387	exonuclease V subunit alpha; Provisional; Region: recD; PRK10875
590409006388	AAA domain; Region: AAA_30; pfam13604
590409006389	Family description; Region: UvrD_C_2; pfam13538
590409006390	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
590409006391	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
590409006392	ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776
590409006393	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
590409006394	ATP binding site [chemical binding]; other site
590409006395	Mg++ binding site [ion binding]; other site
590409006396	motif III; other site
590409006397	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
590409006398	nucleotide binding region [chemical binding]; other site
590409006399	ATP-binding site [chemical binding]; other site
590409006400	RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501
590409006401	putative RNA binding site [nucleotide binding]; other site
590409006402	O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520
590409006403	O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055
590409006404	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
590409006405	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
590409006406	GTP-binding protein YchF; Reviewed; Region: PRK09601
590409006407	YchF GTPase; Region: YchF; cd01900
590409006408	G1 box; other site
590409006409	GTP/Mg2+ binding site [chemical binding]; other site
590409006410	Switch I region; other site
590409006411	G2 box; other site
590409006412	Switch II region; other site
590409006413	G3 box; other site
590409006414	G4 box; other site
590409006415	G5 box; other site
590409006416	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
590409006417	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
590409006418	putative active site [active]
590409006419	catalytic residue [active]
590409006420	hypothetical protein; Provisional; Region: PRK10692
590409006421	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
590409006422	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
590409006423	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
590409006424	active site
590409006425	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343
590409006426	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
590409006427	outer membrane lipoprotein LolB; Provisional; Region: lolB; PRK00022
590409006428	Outer membrane lipoprotein LolB; Region: LolB; pfam03550
590409006429	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
590409006430	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
590409006431	tRNA; other site
590409006432	putative tRNA binding site [nucleotide binding]; other site
590409006433	putative NADP binding site [chemical binding]; other site
590409006434	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
590409006435	peptide chain release factor 1; Validated; Region: prfA; PRK00591
590409006436	This domain is found in peptide chain release factors; Region: PCRF; smart00937
590409006437	RF-1 domain; Region: RF-1; pfam00472
590409006438	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
590409006439	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
590409006440	hypothetical protein; Provisional; Region: PRK10941
590409006441	Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369
590409006442	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
590409006443	binding surface
590409006444	TPR motif; other site
590409006445	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
590409006446	2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198
590409006447	Protein of unknown function (DUF1471); Region: DUF1471; pfam07338
590409006448	Protein of unknown function (DUF1471); Region: DUF1471; pfam07338
590409006449	Protein of unknown function (DUF1471); Region: DUF1471; pfam07338
590409006450	NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424
590409006451	Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304
590409006452	ligand binding site [chemical binding]; other site
590409006453	homodimer interface [polypeptide binding]; other site
590409006454	NAD(P) binding site [chemical binding]; other site
590409006455	trimer interface B [polypeptide binding]; other site
590409006456	trimer interface A [polypeptide binding]; other site
590409006457	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
590409006458	pyridine nucleotide transhydrogenase; Provisional; Region: pntB; PRK09444
590409006459	NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233
590409006460	universal stress protein UspE; Provisional; Region: PRK11175
590409006461	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
590409006462	Ligand Binding Site [chemical binding]; other site
590409006463	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
590409006464	Ligand Binding Site [chemical binding]; other site
590409006465	fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161
590409006466	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
590409006467	ligand binding site [chemical binding]; other site
590409006468	flexible hinge region; other site
590409006469	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
590409006470	putative switch regulator; other site
590409006471	non-specific DNA interactions [nucleotide binding]; other site
590409006472	DNA binding site [nucleotide binding]
590409006473	sequence specific DNA binding site [nucleotide binding]; other site
590409006474	putative cAMP binding site [chemical binding]; other site
590409006475	O-6-alkylguanine-DNA:cysteine-protein methyltransferase; Provisional; Region: PRK10286
590409006476	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
590409006477	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
590409006478	DNA binding site [nucleotide binding]
590409006479	active site
590409006480	FIST N domain; Region: FIST; smart00897
590409006481	FIST C domain; Region: FIST_C; pfam10442
590409006482	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
590409006483	dimer interface [polypeptide binding]; other site
590409006484	putative CheW interface [polypeptide binding]; other site
590409006485	Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032
590409006486	Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305
590409006487	E-class dimer interface [polypeptide binding]; other site
590409006488	P-class dimer interface [polypeptide binding]; other site
590409006489	active site
590409006490	Cu2+ binding site [ion binding]; other site
590409006491	Zn2+ binding site [ion binding]; other site
590409006492	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
590409006493	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
590409006494	dimerization interface [polypeptide binding]; other site
590409006495	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
590409006496	dimer interface [polypeptide binding]; other site
590409006497	putative CheW interface [polypeptide binding]; other site
590409006498	Phenolic acid decarboxylase (PAD); Region: PA_decarbox; cl01382
590409006499	Transcriptional regulator [Transcription]; Region: LysR; COG0583
590409006500	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
590409006501	LysR substrate binding domain; Region: LysR_substrate; pfam03466
590409006502	dimerization interface [polypeptide binding]; other site
590409006503	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
590409006504	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
590409006505	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
590409006506	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
590409006507	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
590409006508	Walker A/P-loop; other site
590409006509	ATP binding site [chemical binding]; other site
590409006510	Q-loop/lid; other site
590409006511	ABC transporter signature motif; other site
590409006512	Walker B; other site
590409006513	D-loop; other site
590409006514	H-loop/switch region; other site
590409006515	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
590409006516	dimer interface [polypeptide binding]; other site
590409006517	conserved gate region; other site
590409006518	putative PBP binding loops; other site
590409006519	ABC-ATPase subunit interface; other site
590409006520	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
590409006521	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
590409006522	dimer interface [polypeptide binding]; other site
590409006523	conserved gate region; other site
590409006524	putative PBP binding loops; other site
590409006525	ABC-ATPase subunit interface; other site
590409006526	hypothetical protein; Provisional; Region: PRK11622
590409006527	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
590409006528	cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454
590409006529	Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562
590409006530	putative active site [active]
590409006531	catalytic site [active]
590409006532	putative metal binding site [ion binding]; other site
590409006533	FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289
590409006534	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
590409006535	active site
590409006536	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
590409006537	dinuclear metal binding motif [ion binding]; other site
590409006538	SnoaL-like domain; Region: SnoaL_2; pfam12680
590409006539	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
590409006540	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
590409006541	Membrane bound FAD containing D-sorbitol dehydrogenase; Region: FAD-SLDH; pfam12318
590409006542	Putative bacterial virulence factor; Region: Virul_Fac; pfam10139
590409006543	Virulence factor SrfB; Region: SrfB; pfam07520
590409006544	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
590409006545	triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269
590409006546	NADP binding site [chemical binding]; other site
590409006547	Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases are important virulence factors in pathogenic bacteria. They may be secreted into the medium via a mechanism found in gram-negative bacteria, that does not...; Region: ZnMc_serralysin_like; cd04277
590409006548	active site
590409006549	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
590409006550	Protease inhibitor Inh; Region: Inh; pfam02974
590409006551	type I secretion system ABC transporter, PrtD family; Region: type_I_sec_PrtD; TIGR01842
590409006552	ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246
590409006553	Walker A/P-loop; other site
590409006554	ATP binding site [chemical binding]; other site
590409006555	Q-loop/lid; other site
590409006556	ABC transporter signature motif; other site
590409006557	Walker B; other site
590409006558	D-loop; other site
590409006559	H-loop/switch region; other site
590409006560	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
590409006561	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
590409006562	HlyD family secretion protein; Region: HlyD_3; pfam13437
590409006563	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
590409006564	Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases are important virulence factors in pathogenic bacteria. They may be secreted into the medium via a mechanism found in gram-negative bacteria, that does not...; Region: ZnMc_serralysin_like; cd04277
590409006565	active site
590409006566	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
590409006567	Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases are important virulence factors in pathogenic bacteria. They may be secreted into the medium via a mechanism found in gram-negative bacteria, that does not...; Region: ZnMc_serralysin_like; cd04277
590409006568	active site
590409006569	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
590409006570	Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases are important virulence factors in pathogenic bacteria. They may be secreted into the medium via a mechanism found in gram-negative bacteria, that does not...; Region: ZnMc_serralysin_like; cd04277
590409006571	active site
590409006572	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
590409006573	K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158
590409006574	potassium uptake protein; Region: kup; TIGR00794
590409006575	Endoglucanase C-terminal domain/subunit and related proteins [Carbohydrate transport and metabolism]; Region: COG4305
590409006576	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
590409006577	Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes TehA protein; Region: TDT_TehA; cd09324
590409006578	Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275
590409006579	gating phenylalanine in ion channel; other site
590409006580	Predicted O-acyltransferase [General function prediction only]; Region: COG3274
590409006581	Acyltransferase family; Region: Acyl_transf_3; pfam01757
590409006582	Protein of unknown function (DUF419); Region: DUF419; cl15265
590409006583	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
590409006584	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
590409006585	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
590409006586	DNA binding residues [nucleotide binding]
590409006587	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
590409006588	Transcriptional regulator [Transcription]; Region: LysR; COG0583
590409006589	The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417
590409006590	substrate binding pocket [chemical binding]; other site
590409006591	dimerization interface [polypeptide binding]; other site
590409006592	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
590409006593	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
590409006594	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
590409006595	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
590409006596	Transcriptional regulator [Transcription]; Region: LysR; COG0583
590409006597	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
590409006598	mannosyl-3-phosphoglycerate phosphatase; Reviewed; Region: PRK03669
590409006599	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
590409006600	active site
590409006601	motif I; other site
590409006602	motif II; other site
590409006603	putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915
590409006604	Methyltransferase domain; Region: Methyltransf_31; pfam13847
590409006605	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
590409006606	S-adenosylmethionine binding site [chemical binding]; other site
590409006607	malonic semialdehyde reductase; Provisional; Region: PRK10538
590409006608	classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346
590409006609	putative NAD(P) binding site [chemical binding]; other site
590409006610	homotetramer interface [polypeptide binding]; other site
590409006611	homodimer interface [polypeptide binding]; other site
590409006612	active site
590409006613	hypothetical protein; Provisional; Region: PRK13659
590409006614	Protein of unknown function (DUF1161); Region: DUF1161; pfam06649
590409006615	putative dithiobiotin synthetase; Provisional; Region: PRK12374
590409006616	AAA domain; Region: AAA_26; pfam13500
590409006617	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
590409006618	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
590409006619	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
590409006620	Transcriptional regulator [Transcription]; Region: LysR; COG0583
590409006621	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
590409006622	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
590409006623	dimerization interface [polypeptide binding]; other site
590409006624	substrate binding pocket [chemical binding]; other site
590409006625	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
590409006626	putative substrate translocation pore; other site
590409006627	DNA replication terminus site-binding protein; Provisional; Region: PRK02951
590409006628	fumarate hydratase; Reviewed; Region: fumC; PRK00485
590409006629	Class II fumarases; Region: Fumarase_classII; cd01362
590409006630	active site
590409006631	tetramer interface [polypeptide binding]; other site
590409006632	mannose-6-phosphate isomerase; Provisional; Region: PRK15131
590409006633	Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429
590409006634	Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429
590409006635	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339
590409006636	Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097
590409006637	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816
590409006638	adenosine deaminase; Provisional; Region: PRK09358
590409006639	active site
590409006640	Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504
590409006641	SnoaL-like domain; Region: SnoaL_3; pfam13474
590409006642	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
590409006643	SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593
590409006644	putative oxidoreductase; Provisional; Region: PRK11579
590409006645	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
590409006646	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
590409006647	DNA-binding transcriptional regulator AraC; Provisional; Region: PRK10572
590409006648	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
590409006649	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
590409006650	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
590409006651	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
590409006652	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
590409006653	TM-ABC transporter signature motif; other site
590409006654	L-arabinose transporter ATP-binding protein; Provisional; Region: araG; PRK11288
590409006655	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
590409006656	Walker A/P-loop; other site
590409006657	ATP binding site [chemical binding]; other site
590409006658	Q-loop/lid; other site
590409006659	ABC transporter signature motif; other site
590409006660	Walker B; other site
590409006661	D-loop; other site
590409006662	H-loop/switch region; other site
590409006663	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
590409006664	Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532
590409006665	Periplasmic L-arabinose-binding protein (ABP), a member of a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein superfamily; Region: PBP1_arabinose_binding; cd01540
590409006666	ligand binding site [chemical binding]; other site
590409006667	ribulokinase; Provisional; Region: PRK04123
590409006668	Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781
590409006669	N- and C-terminal domain interface [polypeptide binding]; other site
590409006670	active site
590409006671	MgATP binding site [chemical binding]; other site
590409006672	catalytic site [active]
590409006673	metal binding site [ion binding]; metal-binding site
590409006674	carbohydrate binding site [chemical binding]; other site
590409006675	homodimer interface [polypeptide binding]; other site
590409006676	L-arabinose isomerase; Provisional; Region: PRK02929
590409006677	L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947
590409006678	hexamer (dimer of trimers) interface [polypeptide binding]; other site
590409006679	trimer interface [polypeptide binding]; other site
590409006680	substrate binding site [chemical binding]; other site
590409006681	Mn binding site [ion binding]; other site
590409006682	N-terminal catalytic domain of rhamnogalacturonan lyase, a family 4 polysaccharide lyase; Region: RGL4_N; cd10320
590409006683	active site
590409006684	catalytic site [active]
590409006685	Middle domain of rhamnogalacturonan lyase, a family 4 polysaccharide lyase; Region: RGL4_M; cd10316
590409006686	C-terminal domain of rhamnogalacturonan lyase, a family 4 polysaccharide lyase; Region: RGL4_C; cd10317
590409006687	Ca binding site [ion binding]; other site
590409006688	substrate binding site [chemical binding]; other site
590409006689	oriC-binding nucleoid-associated protein; Provisional; Region: PRK10391
590409006690	electron transport complex protein RsxA; Provisional; Region: PRK05151
590409006691	electron transport complex protein RnfB; Provisional; Region: PRK05113
590409006692	Putative Fe-S cluster; Region: FeS; pfam04060
590409006693	4Fe-4S binding domain; Region: Fer4; pfam00037
590409006694	Predicted NADH:ubiquinone oxidoreductase, subunit RnfC [Energy production and conversion]; Region: RnfC; COG4656
590409006695	SLBB domain; Region: SLBB; pfam10531
590409006696	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
590409006697	electron transport complex protein RnfD; Reviewed; Region: rnfD; PRK00816
590409006698	electron transport complex protein RnfG; Validated; Region: PRK01908
590409006699	electron transport complex RsxE subunit; Provisional; Region: PRK12405
590409006700	endonuclease III; Provisional; Region: PRK10702
590409006701	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
590409006702	minor groove reading motif; other site
590409006703	helix-hairpin-helix signature motif; other site
590409006704	substrate binding pocket [chemical binding]; other site
590409006705	active site
590409006706	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
590409006707	transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681
590409006708	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
590409006709	The C-terminal substrate domain of LysR-type transcriptional regulator CysB contains type 2 periplasmic binding fold; Region: PBP2_CysB; cd08443
590409006710	substrate binding site [chemical binding]; other site
590409006711	putative dimerization interface [polypeptide binding]; other site
590409006712	DNA topoisomerase I subunit omega; Validated; Region: PRK07561
590409006713	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
590409006714	active site
590409006715	interdomain interaction site; other site
590409006716	putative metal-binding site [ion binding]; other site
590409006717	nucleotide binding site [chemical binding]; other site
590409006718	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
590409006719	domain I; other site
590409006720	DNA binding groove [nucleotide binding]
590409006721	phosphate binding site [ion binding]; other site
590409006722	domain II; other site
590409006723	domain III; other site
590409006724	nucleotide binding site [chemical binding]; other site
590409006725	catalytic site [active]
590409006726	domain IV; other site
590409006727	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
590409006728	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
590409006729	Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272
590409006730	Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272
590409006731	hypothetical protein; Provisional; Region: PRK11037
590409006732	Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496
590409006733	putative inner membrane peptidase; Provisional; Region: PRK11778
590409006734	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
590409006735	tandem repeat interface [polypeptide binding]; other site
590409006736	oligomer interface [polypeptide binding]; other site
590409006737	active site residues [active]
590409006738	putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945
590409006739	Escherichia coli K-12 YCIK-like, classical (c) SDRs; Region: Ycik_SDR_c; cd05340
590409006740	NADP binding site [chemical binding]; other site
590409006741	homodimer interface [polypeptide binding]; other site
590409006742	active site
590409006743	ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109
590409006744	Cob(I)alamin adenosyltransferase N terminal; Region: Co_AT_N; pfam12557
590409006745	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561
590409006746	homodimer interface [polypeptide binding]; other site
590409006747	Walker A motif; other site
590409006748	ATP binding site [chemical binding]; other site
590409006749	hydroxycobalamin binding site [chemical binding]; other site
590409006750	Walker B motif; other site
590409006751	23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700
590409006752	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
590409006753	RNA binding surface [nucleotide binding]; other site
590409006754	Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556
590409006755	probable active site [active]
590409006756	hypothetical protein; Provisional; Region: PRK11630
590409006757	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
590409006758	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
590409006759	active site
590409006760	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
590409006761	anthranilate synthase component I; Provisional; Region: PRK13564
590409006762	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
590409006763	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
590409006764	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
590409006765	Glutamine amidotransferase class-I; Region: GATase; pfam00117
590409006766	glutamine binding [chemical binding]; other site
590409006767	catalytic triad [active]
590409006768	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
590409006769	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
590409006770	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
590409006771	bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427
590409006772	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
590409006773	active site
590409006774	ribulose/triose binding site [chemical binding]; other site
590409006775	phosphate binding site [ion binding]; other site
590409006776	substrate (anthranilate) binding pocket [chemical binding]; other site
590409006777	product (indole) binding pocket [chemical binding]; other site
590409006778	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
590409006779	active site
590409006780	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
590409006781	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
590409006782	pyridoxal 5'-phosphate binding site [chemical binding]; other site
590409006783	catalytic residue [active]
590409006784	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
590409006785	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
590409006786	substrate binding site [chemical binding]; other site
590409006787	active site
590409006788	catalytic residues [active]
590409006789	heterodimer interface [polypeptide binding]; other site
590409006790	Oligogalacturonate-specific porin protein (KdgM); Region: KdgM; cl11629
590409006791	outer membrane protein W; Provisional; Region: PRK10959
590409006792	Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727
590409006793	hypothetical protein; Provisional; Region: PRK02868
590409006794	intracellular septation protein A; Reviewed; Region: PRK00259
590409006795	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
590409006796	transport protein TonB; Provisional; Region: PRK10819
590409006797	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
590409006798	YciI-like protein; Reviewed; Region: PRK11370
590409006799	methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041
590409006800	ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181
590409006801	dimer interface [polypeptide binding]; other site
590409006802	ligand binding site [chemical binding]; other site
590409006803	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
590409006804	dimerization interface [polypeptide binding]; other site
590409006805	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
590409006806	dimer interface [polypeptide binding]; other site
590409006807	putative CheW interface [polypeptide binding]; other site
590409006808	cardiolipin synthetase; Reviewed; Region: cls; PRK01642
590409006809	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
590409006810	Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152
590409006811	putative active site [active]
590409006812	catalytic site [active]
590409006813	Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158
590409006814	putative active site [active]
590409006815	catalytic site [active]
590409006816	dsDNA-mimic protein; Reviewed; Region: PRK05094
590409006817	oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079
590409006818	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
590409006819	Walker A/P-loop; other site
590409006820	ATP binding site [chemical binding]; other site
590409006821	Q-loop/lid; other site
590409006822	ABC transporter signature motif; other site
590409006823	Walker B; other site
590409006824	D-loop; other site
590409006825	H-loop/switch region; other site
590409006826	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
590409006827	oligopeptide transporter ATP-binding component; Provisional; Region: oppD; PRK09473
590409006828	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
590409006829	Walker A/P-loop; other site
590409006830	ATP binding site [chemical binding]; other site
590409006831	Q-loop/lid; other site
590409006832	ABC transporter signature motif; other site
590409006833	Walker B; other site
590409006834	D-loop; other site
590409006835	H-loop/switch region; other site
590409006836	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
590409006837	oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406
590409006838	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
590409006839	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
590409006840	dimer interface [polypeptide binding]; other site
590409006841	conserved gate region; other site
590409006842	ABC-ATPase subunit interface; other site
590409006843	oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471
590409006844	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
590409006845	dimer interface [polypeptide binding]; other site
590409006846	conserved gate region; other site
590409006847	putative PBP binding loops; other site
590409006848	ABC-ATPase subunit interface; other site
590409006849	oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104
590409006850	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
590409006851	peptide binding site [polypeptide binding]; other site
590409006852	hypothetical protein; Provisional; Region: PRK11111
590409006853	bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805
590409006854	Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122
590409006855	putative catalytic cysteine [active]
590409006856	C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178
590409006857	putative active site [active]
590409006858	metal binding site [ion binding]; metal-binding site
590409006859	thymidine kinase; Provisional; Region: PRK04296
590409006860	global DNA-binding transcriptional dual regulator H-NS; Provisional; Region: PRK10947
590409006861	Domain in histone-like proteins of HNS family; Region: HNS; smart00528
590409006862	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
590409006863	active site
590409006864	tetramer interface; other site
590409006865	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
590409006866	active site
590409006867	response regulator of RpoS; Provisional; Region: PRK10693
590409006868	phosphorylation site [posttranslational modification]
590409006869	intermolecular recognition site; other site
590409006870	dimerization interface [polypeptide binding]; other site
590409006871	hypothetical protein; Provisional; Region: PRK10279
590409006872	Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228
590409006873	active site
590409006874	nucleophile elbow; other site
590409006875	hypothetical protein; Provisional; Region: PRK04233
590409006876	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
590409006877	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
590409006878	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
590409006879	putative active site [active]
590409006880	putative substrate binding site [chemical binding]; other site
590409006881	putative cosubstrate binding site; other site
590409006882	catalytic site [active]
590409006883	Predicted membrane protein [Function unknown]; Region: COG2860
590409006884	UPF0126 domain; Region: UPF0126; pfam03458
590409006885	UPF0126 domain; Region: UPF0126; pfam03458
590409006886	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
590409006887	putative catalytic site [active]
590409006888	putative phosphate binding site [ion binding]; other site
590409006889	active site
590409006890	metal binding site A [ion binding]; metal-binding site
590409006891	DNA binding site [nucleotide binding]
590409006892	putative AP binding site [nucleotide binding]; other site
590409006893	putative metal binding site B [ion binding]; other site
590409006894	Protein of unknown function (DUF1496); Region: DUF1496; pfam07383
590409006895	DNA topoisomerase III; Provisional; Region: PRK07726
590409006896	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
590409006897	active site
590409006898	putative interdomain interaction site [polypeptide binding]; other site
590409006899	putative metal-binding site [ion binding]; other site
590409006900	putative nucleotide binding site [chemical binding]; other site
590409006901	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
590409006902	domain I; other site
590409006903	DNA binding groove [nucleotide binding]
590409006904	phosphate binding site [ion binding]; other site
590409006905	domain II; other site
590409006906	domain III; other site
590409006907	nucleotide binding site [chemical binding]; other site
590409006908	catalytic site [active]
590409006909	domain IV; other site
590409006910	Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135
590409006911	putative FMN binding site [chemical binding]; other site
590409006912	protease 4; Provisional; Region: PRK10949
590409006913	Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018
590409006914	tandem repeat interface [polypeptide binding]; other site
590409006915	oligomer interface [polypeptide binding]; other site
590409006916	active site residues [active]
590409006917	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_1; cd07019
590409006918	tandem repeat interface [polypeptide binding]; other site
590409006919	oligomer interface [polypeptide binding]; other site
590409006920	active site residues [active]
590409006921	Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963
590409006922	active site
590409006923	homodimer interface [polypeptide binding]; other site
590409006924	Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011
590409006925	Isochorismatase family; Region: Isochorismatase; pfam00857
590409006926	catalytic triad [active]
590409006927	metal binding site [ion binding]; metal-binding site
590409006928	conserved cis-peptide bond; other site
590409006929	Protein of unknown function (DUF1315); Region: DUF1315; cl01215
590409006930	methionine sulfoxide reductase B; Provisional; Region: PRK00222
590409006931	SelR domain; Region: SelR; pfam01641
590409006932	glyceraldehyde-3-phosphate dehydrogenase A; Provisional; Region: gapA; PRK15425
590409006933	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
590409006934	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
590409006935	D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020
590409006936	active site
590409006937	phosphate binding residues; other site
590409006938	catalytic residues [active]
590409006939	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
590409006940	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
590409006941	active site
590409006942	catalytic tetrad [active]
590409006943	Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713
590409006944	PrkA family serine protein kinase; Provisional; Region: PRK15455
590409006945	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
590409006946	Walker A motif; other site
590409006947	ATP binding site [chemical binding]; other site
590409006948	PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798
590409006949	hypothetical protein; Provisional; Region: PRK05325
590409006950	Protein of unknown function (DUF2511); Region: DUF2511; pfam10709
590409006951	Transcriptional regulator [Transcription]; Region: IclR; COG1414
590409006952	Bacterial transcriptional regulator; Region: IclR; pfam01614
590409006953	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
590409006954	homotrimer interaction site [polypeptide binding]; other site
590409006955	putative active site [active]
590409006956	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
590409006957	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
590409006958	substrate binding pocket [chemical binding]; other site
590409006959	membrane-bound complex binding site; other site
590409006960	hinge residues; other site
590409006961	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
590409006962	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
590409006963	dimer interface [polypeptide binding]; other site
590409006964	conserved gate region; other site
590409006965	ABC-ATPase subunit interface; other site
590409006966	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
590409006967	dimer interface [polypeptide binding]; other site
590409006968	conserved gate region; other site
590409006969	putative PBP binding loops; other site
590409006970	ABC-ATPase subunit interface; other site
590409006971	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
590409006972	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
590409006973	Walker A/P-loop; other site
590409006974	ATP binding site [chemical binding]; other site
590409006975	Q-loop/lid; other site
590409006976	ABC transporter signature motif; other site
590409006977	Walker B; other site
590409006978	D-loop; other site
590409006979	H-loop/switch region; other site
590409006980	Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616
590409006981	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Bacterial Cryptic D-Serine Dehydratase; Region: PLPDE_III_cryptic_DSD; cd06818
590409006982	active site
590409006983	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
590409006984	dimer interface [polypeptide binding]; other site
590409006985	substrate binding site [chemical binding]; other site
590409006986	catalytic residue [active]
590409006987	nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055
590409006988	Ferritin-like domain; Region: Ferritin; pfam00210
590409006989	ferroxidase diiron center [ion binding]; other site
590409006990	Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276
590409006991	CopC domain; Region: CopC; cl01012
590409006992	DNA polymerase III subunit theta; Reviewed; Region: PRK10969
590409006993	protease 2; Provisional; Region: PRK10115
590409006994	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
590409006995	phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288
590409006996	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
590409006997	ATP-grasp domain; Region: ATP-grasp; pfam02222
590409006998	keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718
590409006999	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
590409007000	active site
590409007001	intersubunit interface [polypeptide binding]; other site
590409007002	catalytic residue [active]
590409007003	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
590409007004	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
590409007005	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
590409007006	DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302
590409007007	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
590409007008	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
590409007009	putative active site [active]
590409007010	pyruvate kinase; Provisional; Region: PRK05826
590409007011	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
590409007012	domain interfaces; other site
590409007013	active site
590409007014	Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; cl01974
590409007015	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
590409007016	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
590409007017	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
590409007018	putative acyl-acceptor binding pocket; other site
590409007019	putative peptidase; Provisional; Region: PRK11649
590409007020	Opacity-associated protein A N-terminal motif; Region: OapA_N; pfam08525
590409007021	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
590409007022	Peptidase family M23; Region: Peptidase_M23; pfam01551
590409007023	high-affinity zinc transporter periplasmic component; Reviewed; Region: znuA; PRK09545
590409007024	Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019
590409007025	metal binding site [ion binding]; metal-binding site
590409007026	high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544
590409007027	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
590409007028	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
590409007029	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
590409007030	ABC-ATPase subunit  interface; other site
590409007031	dimer interface [polypeptide binding]; other site
590409007032	putative PBP binding regions; other site
590409007033	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
590409007034	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
590409007035	Walker A motif; other site
590409007036	ATP binding site [chemical binding]; other site
590409007037	Walker B motif; other site
590409007038	arginine finger; other site
590409007039	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
590409007040	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
590409007041	RuvA N terminal domain; Region: RuvA_N; pfam01330
590409007042	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
590409007043	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
590409007044	active site
590409007045	putative DNA-binding cleft [nucleotide binding]; other site
590409007046	dimer interface [polypeptide binding]; other site
590409007047	hypothetical protein; Validated; Region: PRK00110
590409007048	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664
590409007049	nudix motif; other site
590409007050	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
590409007051	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
590409007052	dimer interface [polypeptide binding]; other site
590409007053	anticodon binding site; other site
590409007054	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
590409007055	homodimer interface [polypeptide binding]; other site
590409007056	motif 1; other site
590409007057	active site
590409007058	motif 2; other site
590409007059	GAD domain; Region: GAD; pfam02938
590409007060	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
590409007061	active site
590409007062	motif 3; other site
590409007063	hypothetical protein; Provisional; Region: PRK10302
590409007064	Uncharacterized relative of glutathione S-transferase, MAPEG superfamily [General function prediction only]; Region: COG3788
590409007065	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
590409007066	S-adenosylmethionine binding site [chemical binding]; other site
590409007067	Methyltransferase domain; Region: Methyltransf_23; pfam13489
590409007068	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
590409007069	S-adenosylmethionine binding site [chemical binding]; other site
590409007070	copper homeostasis protein CutC; Provisional; Region: PRK11572
590409007071	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_4; cd07268
590409007072	putative metal binding site [ion binding]; other site
590409007073	Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018
590409007074	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
590409007075	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
590409007076	active site
590409007077	HIGH motif; other site
590409007078	KMSK motif region; other site
590409007079	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
590409007080	tRNA binding surface [nucleotide binding]; other site
590409007081	anticodon binding site; other site
590409007082	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
590409007083	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
590409007084	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
590409007085	dimer interface [polypeptide binding]; other site
590409007086	putative CheW interface [polypeptide binding]; other site
590409007087	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
590409007088	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
590409007089	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
590409007090	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
590409007091	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3132
590409007092	hypothetical protein; Provisional; Region: PRK11239
590409007093	ribosomal-protein-S5-alanine N-acetyltransferase; Provisional; Region: PRK10809
590409007094	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
590409007095	multidrug resistance protein MdtH; Provisional; Region: PRK11646
590409007096	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
590409007097	putative substrate translocation pore; other site
590409007098	glutaredoxin 2; Provisional; Region: PRK10387
590409007099	GST_N family, Glutaredoxin 2 (GRX2) subfamily; composed of bacterial proteins similar to E. coli GRX2, an atypical GRX with a molecular mass of about 24kD, compared with other GRXs which are 9-12kD in size. GRX2 adopts a GST fold containing an N-terminal...; Region: GST_N_GRX2; cd03037
590409007100	C-terminal domain interface [polypeptide binding]; other site
590409007101	GSH binding site (G-site) [chemical binding]; other site
590409007102	catalytic residues [active]
590409007103	putative dimer interface [polypeptide binding]; other site
590409007104	C-terminal, alpha helical domain of Glutaredoxin 2; Region: GST_C_GRX2; cd03199
590409007105	N-terminal domain interface [polypeptide binding]; other site
590409007106	lipoprotein; Provisional; Region: PRK10598
590409007107	Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381
590409007108	putative hydrolase; Validated; Region: PRK09248
590409007109	Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437
590409007110	active site
590409007111	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
590409007112	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
590409007113	DNA-binding site [nucleotide binding]; DNA binding site
590409007114	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
590409007115	GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009
590409007116	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
590409007117	dimer interface [polypeptide binding]; other site
590409007118	ADP-ribose binding site [chemical binding]; other site
590409007119	active site
590409007120	nudix motif; other site
590409007121	metal binding site [ion binding]; metal-binding site
590409007122	Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far.  This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases).  Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062
590409007123	B1 nucleotide binding pocket [chemical binding]; other site
590409007124	B2 nucleotide binding pocket [chemical binding]; other site
590409007125	CAS motifs; other site
590409007126	active site
590409007127	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
590409007128	nudix motif; other site
590409007129	Old yellow enzyme (OYE)-related FMN binding domain, group 5.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_5_FMN; cd04747
590409007130	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
590409007131	putative active site [active]
590409007132	putative FMN binding site [chemical binding]; other site
590409007133	putative substrate binding site [chemical binding]; other site
590409007134	putative catalytic residue [active]
590409007135	Predicted transcriptional regulators [Transcription]; Region: COG1733
590409007136	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
590409007137	dimerization interface [polypeptide binding]; other site
590409007138	putative DNA binding site [nucleotide binding]; other site
590409007139	putative Zn2+ binding site [ion binding]; other site
590409007140	multicopper oxidase; Provisional; Region: PRK10965
590409007141	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
590409007142	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
590409007143	ATP-grasp domain; Region: ATP-grasp_4; cl17255
590409007144	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
590409007145	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
590409007146	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
590409007147	CcdB protein; Region: CcdB; cl03380
590409007148	cell division protein MukB; Provisional; Region: mukB; PRK04863
590409007149	P-loop containing region of AAA domain; Region: AAA_29; cl17516
590409007150	Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558
590409007151	condesin subunit E; Provisional; Region: PRK05256
590409007152	condesin subunit F; Provisional; Region: PRK05260
590409007153	Methyltransferase domain; Region: Methyltransf_31; pfam13847
590409007154	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
590409007155	S-adenosylmethionine binding site [chemical binding]; other site
590409007156	Uncharacterized conserved protein [Function unknown]; Region: COG1434
590409007157	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
590409007158	putative active site [active]
590409007159	hypothetical protein; Provisional; Region: PRK10593
590409007160	Right handed beta helix region; Region: Beta_helix; pfam13229
590409007161	3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450
590409007162	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
590409007163	Ligand binding site; other site
590409007164	oligomer interface; other site
590409007165	Trm112p-like protein; Region: Trm112p; cl01066
590409007166	tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652
590409007167	Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663
590409007168	lipid transporter ATP-binding/permease protein; Provisional; Region: PRK11176
590409007169	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
590409007170	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
590409007171	Walker A/P-loop; other site
590409007172	ATP binding site [chemical binding]; other site
590409007173	Q-loop/lid; other site
590409007174	ABC transporter signature motif; other site
590409007175	Walker B; other site
590409007176	D-loop; other site
590409007177	H-loop/switch region; other site
590409007178	ComEC family competence protein; Provisional; Region: PRK11539
590409007179	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
590409007180	Competence protein; Region: Competence; pfam03772
590409007181	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
590409007182	hypothetical protein; Provisional; Region: PRK05423
590409007183	exonuclease I; Provisional; Region: sbcB; PRK11779
590409007184	N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138
590409007185	active site
590409007186	catalytic site [active]
590409007187	substrate binding site [chemical binding]; other site
590409007188	Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411
590409007189	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
590409007190	Flagellar regulator YcgR; Region: YcgR; pfam07317
590409007191	c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581
590409007192	PilZ domain; Region: PilZ; pfam07238
590409007193	triphosphoribosyl-dephospho-CoA synthase CitG; Region: citrate_citG; TIGR03125
590409007194	Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase; Region: CitX; pfam03802
590409007195	Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051
590409007196	HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231
590409007197	citrate lyase subunit gamma; Provisional; Region: PRK13253
590409007198	Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053
590409007199	Citrate lyase ligase; Region: Citrate_lyase_ligase; cd02169
590409007200	putative active site [active]
590409007201	(T/H)XGH motif; other site
590409007202	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
590409007203	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
590409007204	2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390
590409007205	sensor histidine kinase DpiB; Provisional; Region: dpiB; PRK15053
590409007206	PAS domain; Region: PAS; smart00091
590409007207	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
590409007208	ATP binding site [chemical binding]; other site
590409007209	Mg2+ binding site [ion binding]; other site
590409007210	G-X-G motif; other site
590409007211	Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565
590409007212	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
590409007213	active site
590409007214	phosphorylation site [posttranslational modification]
590409007215	intermolecular recognition site; other site
590409007216	dimerization interface [polypeptide binding]; other site
590409007217	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
590409007218	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
590409007219	dimerization interface [polypeptide binding]; other site
590409007220	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
590409007221	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
590409007222	dimer interface [polypeptide binding]; other site
590409007223	putative CheW interface [polypeptide binding]; other site
590409007224	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
590409007225	atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266
590409007226	putative NAD(P) binding site [chemical binding]; other site
590409007227	ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489
590409007228	ATP phosphoribosyltransferase; Region: hisG; TIGR00070
590409007229	ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455
590409007230	Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141
590409007231	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
590409007232	NAD binding site [chemical binding]; other site
590409007233	dimerization interface [polypeptide binding]; other site
590409007234	product binding site; other site
590409007235	substrate binding site [chemical binding]; other site
590409007236	zinc binding site [ion binding]; other site
590409007237	catalytic residues [active]
590409007238	histidinol-phosphate aminotransferase; Provisional; Region: PRK01688
590409007239	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
590409007240	pyridoxal 5'-phosphate binding site [chemical binding]; other site
590409007241	homodimer interface [polypeptide binding]; other site
590409007242	catalytic residue [active]
590409007243	imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446
590409007244	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
590409007245	active site
590409007246	motif I; other site
590409007247	motif II; other site
590409007248	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
590409007249	putative active site pocket [active]
590409007250	4-fold oligomerization interface [polypeptide binding]; other site
590409007251	metal binding residues [ion binding]; metal-binding site
590409007252	3-fold/trimer interface [polypeptide binding]; other site
590409007253	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13170
590409007254	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
590409007255	putative active site [active]
590409007256	oxyanion strand; other site
590409007257	catalytic triad [active]
590409007258	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
590409007259	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
590409007260	catalytic residues [active]
590409007261	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
590409007262	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
590409007263	substrate binding site [chemical binding]; other site
590409007264	glutamase interaction surface [polypeptide binding]; other site
590409007265	Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139
590409007266	bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759
590409007267	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
590409007268	metal binding site [ion binding]; metal-binding site
590409007269	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
590409007270	IHF dimer interface [polypeptide binding]; other site
590409007271	IHF - DNA interface [nucleotide binding]; other site
590409007272	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299
590409007273	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
590409007274	RNA binding site [nucleotide binding]; other site
590409007275	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
590409007276	RNA binding site [nucleotide binding]; other site
590409007277	S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689
590409007278	RNA binding site [nucleotide binding]; other site
590409007279	S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690
590409007280	RNA binding site [nucleotide binding]; other site
590409007281	S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691
590409007282	RNA binding site [nucleotide binding]; other site
590409007283	cytidylate kinase; Provisional; Region: cmk; PRK00023
590409007284	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
590409007285	CMP-binding site; other site
590409007286	The sites determining sugar specificity; other site
590409007287	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
590409007288	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
590409007289	hinge; other site
590409007290	active site
590409007291	Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT).  PSAT is active as...; Region: PSAT_like; cd00611
590409007292	homodimer interface [polypeptide binding]; other site
590409007293	substrate-cofactor binding pocket; other site
590409007294	pyridoxal 5'-phosphate binding site [chemical binding]; other site
590409007295	catalytic residue [active]
590409007296	uncharacterized domain; Region: TIGR00702
590409007297	YcaO-like family; Region: YcaO; pfam02624
590409007298	Formate/nitrite transporter; Region: Form_Nir_trans; cl00927
590409007299	formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255
590409007300	Pyruvate formate lyase 1; Region: PFL1; cd01678
590409007301	coenzyme A binding site [chemical binding]; other site
590409007302	active site
590409007303	catalytic residues [active]
590409007304	glycine loop; other site
590409007305	pyruvate formate lyase-activating enzyme 1; Provisional; Region: pflA; PRK11145
590409007306	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
590409007307	FeS/SAM binding site; other site
590409007308	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
590409007309	DNA-binding interface [nucleotide binding]; DNA binding site
590409007310	HTH-like domain; Region: HTH_21; pfam13276
590409007311	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
590409007312	Integrase core domain; Region: rve; pfam00665
590409007313	Integrase core domain; Region: rve_3; pfam13683
590409007314	Transcriptional regulator [Transcription]; Region: LysR; COG0583
590409007315	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
590409007316	LysR substrate binding domain; Region: LysR_substrate; pfam03466
590409007317	putative MFS family transporter protein; Provisional; Region: PRK03633
590409007318	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
590409007319	putative substrate translocation pore; other site
590409007320	transcriptional regulator; Provisional; Region: PRK10632
590409007321	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
590409007322	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
590409007323	putative effector binding pocket; other site
590409007324	dimerization interface [polypeptide binding]; other site
590409007325	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
590409007326	Predicted protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: COG3531
590409007327	DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025
590409007328	catalytic residues [active]
590409007329	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
590409007330	GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046
590409007331	putative C-terminal domain interface [polypeptide binding]; other site
590409007332	putative GSH binding site (G-site) [chemical binding]; other site
590409007333	putative dimer interface [polypeptide binding]; other site
590409007334	C-terminal, alpha helical domain of GTT1-like Glutathione S-transferases; Region: GST_C_GTT1_like; cd03189
590409007335	putative N-terminal domain interface [polypeptide binding]; other site
590409007336	putative dimer interface [polypeptide binding]; other site
590409007337	putative substrate binding pocket (H-site) [chemical binding]; other site
590409007338	Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958
590409007339	seryl-tRNA synthetase; Provisional; Region: PRK05431
590409007340	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
590409007341	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
590409007342	dimer interface [polypeptide binding]; other site
590409007343	active site
590409007344	motif 1; other site
590409007345	motif 2; other site
590409007346	motif 3; other site
590409007347	recombination factor protein RarA; Reviewed; Region: PRK13342
590409007348	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
590409007349	Walker A motif; other site
590409007350	ATP binding site [chemical binding]; other site
590409007351	Walker B motif; other site
590409007352	arginine finger; other site
590409007353	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
590409007354	Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548
590409007355	lipoprotein chaperone; Reviewed; Region: lolA; PRK00031
590409007356	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
590409007357	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
590409007358	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
590409007359	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
590409007360	leucine-responsive transcriptional regulator; Provisional; Region: PRK11169
590409007361	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
590409007362	putative DNA binding site [nucleotide binding]; other site
590409007363	putative Zn2+ binding site [ion binding]; other site
590409007364	AsnC family; Region: AsnC_trans_reg; pfam01037
590409007365	thioredoxin reductase; Provisional; Region: PRK10262
590409007366	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
590409007367	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
590409007368	cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11174
590409007369	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
590409007370	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
590409007371	Walker A/P-loop; other site
590409007372	ATP binding site [chemical binding]; other site
590409007373	Q-loop/lid; other site
590409007374	ABC transporter signature motif; other site
590409007375	Walker B; other site
590409007376	D-loop; other site
590409007377	H-loop/switch region; other site
590409007378	cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160
590409007379	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
590409007380	Walker A/P-loop; other site
590409007381	ATP binding site [chemical binding]; other site
590409007382	Q-loop/lid; other site
590409007383	ABC transporter signature motif; other site
590409007384	Walker B; other site
590409007385	D-loop; other site
590409007386	H-loop/switch region; other site
590409007387	leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301
590409007388	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
590409007389	rRNA binding site [nucleotide binding]; other site
590409007390	predicted 30S ribosome binding site; other site
590409007391	ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034
590409007392	Clp amino terminal domain; Region: Clp_N; pfam02861
590409007393	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
590409007394	Walker A motif; other site
590409007395	ATP binding site [chemical binding]; other site
590409007396	Walker B motif; other site
590409007397	arginine finger; other site
590409007398	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
590409007399	Walker A motif; other site
590409007400	ATP binding site [chemical binding]; other site
590409007401	Walker B motif; other site
590409007402	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
590409007403	Uncharacterized conserved protein [Function unknown]; Region: COG2127
590409007404	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
590409007405	DNA-binding site [nucleotide binding]; DNA binding site
590409007406	RNA-binding motif; other site
590409007407	Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593
590409007408	Protein of unknown function (DUF2813); Region: DUF2813; pfam11398
590409007409	TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family.  The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026
590409007410	putative active site [active]
590409007411	putative metal-binding site [ion binding]; other site
590409007412	hybrid cluster protein; Provisional; Region: PRK05290
590409007413	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
590409007414	ACS interaction site; other site
590409007415	CODH interaction site; other site
590409007416	Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914
590409007417	hybrid metal cluster; other site
590409007418	HCP oxidoreductase, NADH-dependent; Provisional; Region: PRK10684
590409007419	Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215
590409007420	FAD binding pocket [chemical binding]; other site
590409007421	FAD binding motif [chemical binding]; other site
590409007422	phosphate binding motif [ion binding]; other site
590409007423	beta-alpha-beta structure motif; other site
590409007424	NAD binding pocket [chemical binding]; other site
590409007425	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
590409007426	catalytic loop [active]
590409007427	iron binding site [ion binding]; other site
590409007428	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
590409007429	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
590409007430	NAD(P) binding site [chemical binding]; other site
590409007431	active site
590409007432	N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023
590409007433	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
590409007434	amidase catalytic site [active]
590409007435	Zn binding residues [ion binding]; other site
590409007436	substrate binding site [chemical binding]; other site
590409007437	hypothetical protein; Provisional; Region: PRK02877
590409007438	arginine transporter ATP-binding subunit; Provisional; Region: artP; PRK11124
590409007439	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
590409007440	Walker A/P-loop; other site
590409007441	ATP binding site [chemical binding]; other site
590409007442	Q-loop/lid; other site
590409007443	ABC transporter signature motif; other site
590409007444	Walker B; other site
590409007445	D-loop; other site
590409007446	H-loop/switch region; other site
590409007447	putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007
590409007448	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
590409007449	substrate binding pocket [chemical binding]; other site
590409007450	membrane-bound complex binding site; other site
590409007451	hinge residues; other site
590409007452	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
590409007453	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
590409007454	dimer interface [polypeptide binding]; other site
590409007455	conserved gate region; other site
590409007456	putative PBP binding loops; other site
590409007457	ABC-ATPase subunit interface; other site
590409007458	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
590409007459	dimer interface [polypeptide binding]; other site
590409007460	conserved gate region; other site
590409007461	putative PBP binding loops; other site
590409007462	ABC-ATPase subunit interface; other site
590409007463	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
590409007464	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
590409007465	substrate binding pocket [chemical binding]; other site
590409007466	membrane-bound complex binding site; other site
590409007467	hinge residues; other site
590409007468	23S rRNA methyluridine methyltransferase; Reviewed; Region: rumB; PRK03522
590409007469	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
590409007470	S-adenosylmethionine binding site [chemical binding]; other site
590409007471	Protein of unknown function (DUF2593); Region: DUF2593; pfam10767
590409007472	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
590409007473	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
590409007474	dimer interface [polypeptide binding]; other site
590409007475	conserved gate region; other site
590409007476	putative PBP binding loops; other site
590409007477	ABC-ATPase subunit interface; other site
590409007478	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
590409007479	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
590409007480	dimer interface [polypeptide binding]; other site
590409007481	conserved gate region; other site
590409007482	putative PBP binding loops; other site
590409007483	ABC-ATPase subunit interface; other site
590409007484	putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607
590409007485	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
590409007486	Walker A/P-loop; other site
590409007487	ATP binding site [chemical binding]; other site
590409007488	Q-loop/lid; other site
590409007489	ABC transporter signature motif; other site
590409007490	Walker B; other site
590409007491	D-loop; other site
590409007492	H-loop/switch region; other site
590409007493	TOBE domain; Region: TOBE_2; pfam08402
590409007494	putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682
590409007495	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
590409007496	Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722
590409007497	ribosomal protein S6 modification protein; Provisional; Region: PRK10446
590409007498	RimK-like ATP-grasp domain; Region: RimK; pfam08443
590409007499	This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146
590409007500	dimer interface [polypeptide binding]; other site
590409007501	FMN binding site [chemical binding]; other site
590409007502	NADPH bind site [chemical binding]; other site
590409007503	Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066
590409007504	GSH binding site [chemical binding]; other site
590409007505	catalytic residues [active]
590409007506	Putative inner membrane protein of Enterobacteriaceae; Region: YbjM; pfam11045
590409007507	putative transporter; Provisional; Region: PRK04972
590409007508	Predicted Permease Membrane Region; Region: Asp-Al_Ex; cl06061
590409007509	TrkA-C domain; Region: TrkA_C; pfam02080
590409007510	TrkA-C domain; Region: TrkA_C; pfam02080
590409007511	AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625
590409007512	DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681
590409007513	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
590409007514	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
590409007515	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
590409007516	D-alanyl-D-alanine carboxypeptidase fraction C; Provisional; Region: PRK10001
590409007517	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943
590409007518	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
590409007519	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
590409007520	GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047
590409007521	putative C-terminal domain interface [polypeptide binding]; other site
590409007522	putative GSH binding site (G-site) [chemical binding]; other site
590409007523	putative dimer interface [polypeptide binding]; other site
590409007524	C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180
590409007525	putative N-terminal domain interface [polypeptide binding]; other site
590409007526	putative dimer interface [polypeptide binding]; other site
590409007527	putative substrate binding pocket (H-site) [chemical binding]; other site
590409007528	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
590409007529	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
590409007530	ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862
590409007531	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
590409007532	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
590409007533	FeS/SAM binding site; other site
590409007534	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
590409007535	putative active site [active]
590409007536	Predicted membrane protein [Function unknown]; Region: COG2311
590409007537	hypothetical protein; Provisional; Region: PRK10835
590409007538	GTP cyclohydrolase I; Provisional; Region: folE; PRK09347
590409007539	active site
590409007540	methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048
590409007541	ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144
590409007542	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
590409007543	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
590409007544	dimer interface [polypeptide binding]; other site
590409007545	putative CheW interface [polypeptide binding]; other site
590409007546	ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144
590409007547	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
590409007548	dimer interface [polypeptide binding]; other site
590409007549	putative CheW interface [polypeptide binding]; other site
590409007550	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
590409007551	ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144
590409007552	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
590409007553	dimer interface [polypeptide binding]; other site
590409007554	putative CheW interface [polypeptide binding]; other site
590409007555	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304
590409007556	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
590409007557	dimer interface [polypeptide binding]; other site
590409007558	putative CheW interface [polypeptide binding]; other site
590409007559	Transcriptional regulator [Transcription]; Region: LysR; COG0583
590409007560	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
590409007561	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
590409007562	dimerization interface [polypeptide binding]; other site
590409007563	class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300
590409007564	S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818
590409007565	substrate binding site [chemical binding]; other site
590409007566	catalytic Zn binding site [ion binding]; other site
590409007567	NAD binding site [chemical binding]; other site
590409007568	structural Zn binding site [ion binding]; other site
590409007569	dimer interface [polypeptide binding]; other site
590409007570	S-formylglutathione hydrolase; Region: PLN02442
590409007571	S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821
590409007572	KTSC domain; Region: KTSC; pfam13619
590409007573	Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371
590409007574	Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172
590409007575	putative active site [active]
590409007576	metal binding site [ion binding]; metal-binding site
590409007577	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
590409007578	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
590409007579	Walker A/P-loop; other site
590409007580	ATP binding site [chemical binding]; other site
590409007581	Q-loop/lid; other site
590409007582	ABC transporter signature motif; other site
590409007583	Walker B; other site
590409007584	D-loop; other site
590409007585	H-loop/switch region; other site
590409007586	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
590409007587	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
590409007588	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
590409007589	TM-ABC transporter signature motif; other site
590409007590	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
590409007591	Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes [Energy production and conversion]; Region: AceF; COG0508
590409007592	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
590409007593	Predicted enzyme involved in methoxymalonyl-ACP biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FkbH; COG3882
590409007594	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
590409007595	active site
590409007596	motif I; other site
590409007597	motif II; other site
590409007598	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK06816
590409007599	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
590409007600	active site
590409007601	putative arabinose transporter; Provisional; Region: PRK03545
590409007602	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
590409007603	putative substrate translocation pore; other site
590409007604	lysine transporter; Provisional; Region: PRK10836
590409007605	putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837
590409007606	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
590409007607	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
590409007608	putative dimerization interface [polypeptide binding]; other site
590409007609	Predicted membrane protein [Function unknown]; Region: COG2855
590409007610	endonuclease IV; Provisional; Region: PRK01060
590409007611	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
590409007612	AP (apurinic/apyrimidinic) site pocket; other site
590409007613	DNA interaction; other site
590409007614	Metal-binding active site; metal-binding site
590409007615	PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712
590409007616	N-terminal domain of the phosphotransferase system fructose-specific component IIB [Carbohydrate transport and metabolism]; Region: COG3925
590409007617	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
590409007618	active site
590409007619	P-loop; other site
590409007620	phosphorylation site [posttranslational modification]
590409007621	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425
590409007622	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
590409007623	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
590409007624	putative substrate binding site [chemical binding]; other site
590409007625	putative ATP binding site [chemical binding]; other site
590409007626	bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK11109
590409007627	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
590409007628	active site
590409007629	phosphorylation site [posttranslational modification]
590409007630	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
590409007631	dimerization domain swap beta strand [polypeptide binding]; other site
590409007632	regulatory protein interface [polypeptide binding]; other site
590409007633	active site
590409007634	regulatory phosphorylation site [posttranslational modification]; other site
590409007635	sugar efflux transporter B; Provisional; Region: PRK15011
590409007636	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
590409007637	putative substrate translocation pore; other site
590409007638	Flagellin N-methylase; Region: FliB; cl00497
590409007639	elongation factor P; Provisional; Region: PRK04542
590409007640	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
590409007641	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
590409007642	RNA binding site [nucleotide binding]; other site
590409007643	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
590409007644	RNA binding site [nucleotide binding]; other site
590409007645	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
590409007646	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
590409007647	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
590409007648	outer membrane lipoprotein; Provisional; Region: spr; PRK10838
590409007649	NlpC/P60 family; Region: NLPC_P60; pfam00877
590409007650	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
590409007651	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497
590409007652	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174
590409007653	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
590409007654	dimer interface [polypeptide binding]; other site
590409007655	conserved gate region; other site
590409007656	putative PBP binding loops; other site
590409007657	ABC-ATPase subunit interface; other site
590409007658	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239
590409007659	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
590409007660	dimer interface [polypeptide binding]; other site
590409007661	conserved gate region; other site
590409007662	putative PBP binding loops; other site
590409007663	ABC-ATPase subunit interface; other site
590409007664	microcin C ABC transporter ATP-binding protein YejF; Provisional; Region: PRK15134
590409007665	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
590409007666	Walker A/P-loop; other site
590409007667	ATP binding site [chemical binding]; other site
590409007668	Q-loop/lid; other site
590409007669	ABC transporter signature motif; other site
590409007670	Walker B; other site
590409007671	D-loop; other site
590409007672	H-loop/switch region; other site
590409007673	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
590409007674	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
590409007675	Walker A/P-loop; other site
590409007676	ATP binding site [chemical binding]; other site
590409007677	Q-loop/lid; other site
590409007678	ABC transporter signature motif; other site
590409007679	Walker B; other site
590409007680	D-loop; other site
590409007681	H-loop/switch region; other site
590409007682	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
590409007683	hypothetical protein; Provisional; Region: PRK11835
590409007684	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
590409007685	bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102
590409007686	putative substrate translocation pore; other site
590409007687	16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839
590409007688	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
590409007689	RNA binding surface [nucleotide binding]; other site
590409007690	Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553
590409007691	active site
590409007692	uracil binding [chemical binding]; other site
590409007693	probable metal-binding protein; Region: matur_matur; TIGR03853
590409007694	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
590409007695	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
590409007696	ATP binding site [chemical binding]; other site
590409007697	putative Mg++ binding site [ion binding]; other site
590409007698	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
590409007699	nucleotide binding region [chemical binding]; other site
590409007700	ATP-binding site [chemical binding]; other site
590409007701	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
590409007702	5S rRNA interface [nucleotide binding]; other site
590409007703	CTC domain interface [polypeptide binding]; other site
590409007704	L16 interface [polypeptide binding]; other site
590409007705	oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890
590409007706	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
590409007707	putative substrate translocation pore; other site
590409007708	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
590409007709	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
590409007710	active site
590409007711	phosphorylation site [posttranslational modification]
590409007712	intermolecular recognition site; other site
590409007713	dimerization interface [polypeptide binding]; other site
590409007714	LytTr DNA-binding domain; Region: LytTR; pfam04397
590409007715	Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275
590409007716	5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694
590409007717	Histidine kinase; Region: His_kinase; pfam06580
590409007718	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
590409007719	ATP binding site [chemical binding]; other site
590409007720	Mg2+ binding site [ion binding]; other site
590409007721	G-X-G motif; other site
590409007722	Nucleoid-associated protein [General function prediction only]; Region: COG3081
590409007723	nucleoid-associated protein NdpA; Validated; Region: PRK00378
590409007724	hypothetical protein; Provisional; Region: PRK13689
590409007725	Predicted hydrolase of alkaline phosphatase superfamily [General function prediction only]; Region: COG3083
590409007726	Domain of unknown function (DUF3413); Region: DUF3413; pfam11893
590409007727	Sulfatase; Region: Sulfatase; cl17466
590409007728	integrase; Provisional; Region: PRK09692
590409007729	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
590409007730	active site
590409007731	Int/Topo IB signature motif; other site
590409007732	Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523
590409007733	AntA/AntB antirepressor; Region: AntA; pfam08346
590409007734	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4643
590409007735	Zinc-binding domain of primase-helicase; Region: Prim_Zn_Ribbon; smart00778
590409007736	TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029
590409007737	active site
590409007738	metal binding site [ion binding]; metal-binding site
590409007739	interdomain interaction site; other site
590409007740	Superfamily II helicase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG5519
590409007741	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
590409007742	catalytic residue [active]
590409007743	Helix-turn-helix domain; Region: HTH_28; pfam13518
590409007744	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
590409007745	Q-loop/lid; other site
590409007746	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
590409007747	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
590409007748	Coenzyme A binding pocket [chemical binding]; other site
590409007749	CAAX protease self-immunity; Region: Abi; pfam02517
590409007750	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
590409007751	ArsC family; Region: ArsC; pfam03960
590409007752	catalytic residues [active]
590409007753	arsenical pump membrane protein; Provisional; Region: PRK15445
590409007754	Anion permease ArsB.  These permeases have been shown to export arsenate and antimonite in eubacteria and archaea.  A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118
590409007755	transmembrane helices; other site
590409007756	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
590409007757	dimerization interface [polypeptide binding]; other site
590409007758	putative DNA binding site [nucleotide binding]; other site
590409007759	putative Zn2+ binding site [ion binding]; other site
590409007760	Chagasin family peptidase inhibitor I42; Region: Inhibitor_I42; pfam09394
590409007761	GlpM protein; Region: GlpM; pfam06942
590409007762	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
590409007763	Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins.  IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470
590409007764	putative dimer interface [polypeptide binding]; other site
590409007765	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
590409007766	Na binding site [ion binding]; other site
590409007767	Allophanate hydrolase subunit 2; Region: AHS2; smart00797
590409007768	Allophanate hydrolase subunit 1; Region: AHS1; smart00796
590409007769	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049
590409007770	acetyl-CoA carboxylase biotin carboxylase subunit; Provisional; Region: PRK12833
590409007771	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
590409007772	ATP-grasp domain; Region: ATP-grasp_4; cl17255
590409007773	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
590409007774	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
590409007775	carboxyltransferase (CT) interaction site; other site
590409007776	biotinylation site [posttranslational modification]; other site
590409007777	hypothetical protein; Provisional; Region: PRK12569
590409007778	Transcriptional regulator [Transcription]; Region: LysR; COG0583
590409007779	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
590409007780	The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412
590409007781	putative substrate binding pocket [chemical binding]; other site
590409007782	dimerization interface [polypeptide binding]; other site
590409007783	Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807
590409007784	MarR family; Region: MarR_2; cl17246
590409007785	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
590409007786	outer membrane protein X; Provisional; Region: ompX; PRK09408
590409007787	Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006
590409007788	EamA-like transporter family; Region: EamA; pfam00892
590409007789	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
590409007790	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
590409007791	dimerization interface [polypeptide binding]; other site
590409007792	DPS ferroxidase diiron center [ion binding]; other site
590409007793	ion pore; other site
590409007794	glutamine ABC transporter periplasmic protein; Reviewed; Region: glnH; PRK09495
590409007795	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
590409007796	substrate binding pocket [chemical binding]; other site
590409007797	membrane-bound complex binding site; other site
590409007798	hinge residues; other site
590409007799	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
590409007800	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
590409007801	dimer interface [polypeptide binding]; other site
590409007802	conserved gate region; other site
590409007803	putative PBP binding loops; other site
590409007804	ABC-ATPase subunit interface; other site
590409007805	glutamine ABC transporter ATP-binding protein; Reviewed; Region: glnQ; PRK09493
590409007806	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
590409007807	Walker A/P-loop; other site
590409007808	ATP binding site [chemical binding]; other site
590409007809	Q-loop/lid; other site
590409007810	ABC transporter signature motif; other site
590409007811	Walker B; other site
590409007812	D-loop; other site
590409007813	H-loop/switch region; other site
590409007814	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
590409007815	Interdomain contacts; other site
590409007816	Cytokine receptor motif; other site
590409007817	Protein of unknown function (DUF1349); Region: DUF1349; cl01397
590409007818	PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397
590409007819	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
590409007820	active site
590409007821	Peptidase M3-like family, a zincin metallopeptidase, includes M3 and M32 families; Region: M3_like; cd06258
590409007822	active site
590409007823	Zn binding site [ion binding]; other site
590409007824	glycosyl transferase family protein; Provisional; Region: PRK08136
590409007825	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
590409007826	ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747
590409007827	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
590409007828	DEAD_2; Region: DEAD_2; pfam06733
590409007829	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
590409007830	hypothetical protein; Provisional; Region: PRK13681
590409007831	beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098
590409007832	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
590409007833	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
590409007834	4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160
590409007835	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
590409007836	inhibitor-cofactor binding pocket; inhibition site
590409007837	pyridoxal 5'-phosphate binding site [chemical binding]; other site
590409007838	catalytic residue [active]
590409007839	DNA-binding transcriptional activator FucR; Provisional; Region: PRK10411
590409007840	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
590409007841	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
590409007842	GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043
590409007843	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
590409007844	putative C-terminal domain interface [polypeptide binding]; other site
590409007845	putative GSH binding site (G-site) [chemical binding]; other site
590409007846	putative dimer interface [polypeptide binding]; other site
590409007847	C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194
590409007848	putative substrate binding pocket (H-site) [chemical binding]; other site
590409007849	putative N-terminal domain interface [polypeptide binding]; other site
590409007850	D-alanyl-D-alanine endopeptidase; Provisional; Region: pbpG; PRK11669
590409007851	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
590409007852	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1636
590409007853	Adenylyl cyclase (AC) class IV-like, a subgroup of the CYTH-like superfamily; Region: CYTH-like_AC_IV-like; cd07890
590409007854	putative active site [active]
590409007855	putative metal binding residues [ion binding]; other site
590409007856	signature motif; other site
590409007857	putative triphosphate binding site [ion binding]; other site
590409007858	dimer interface [polypeptide binding]; other site
590409007859	fosfomycin resistance protein FosB; Provisional; Region: PRK04101
590409007860	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
590409007861	active site
590409007862	metal binding site [ion binding]; metal-binding site
590409007863	tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550
590409007864	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
590409007865	FMN binding site [chemical binding]; other site
590409007866	active site
590409007867	catalytic residues [active]
590409007868	substrate binding site [chemical binding]; other site
590409007869	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
590409007870	The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493
590409007871	peptide binding site [polypeptide binding]; other site
590409007872	Di- and tripeptidases [Amino acid transport and metabolism]; Region: PepD; COG2195
590409007873	M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892
590409007874	metal binding site [ion binding]; metal-binding site
590409007875	dimer interface [polypeptide binding]; other site
590409007876	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
590409007877	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
590409007878	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
590409007879	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
590409007880	EamA-like transporter family; Region: EamA; pfam00892
590409007881	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
590409007882	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
590409007883	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
590409007884	helicase 45; Provisional; Region: PTZ00424
590409007885	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
590409007886	ATP binding site [chemical binding]; other site
590409007887	Mg++ binding site [ion binding]; other site
590409007888	motif III; other site
590409007889	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
590409007890	nucleotide binding region [chemical binding]; other site
590409007891	ATP-binding site [chemical binding]; other site
590409007892	putative efflux pump membrane fusion protein; Provisional; Region: PRK03598
590409007893	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
590409007894	HlyD family secretion protein; Region: HlyD_3; pfam13437
590409007895	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
590409007896	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
590409007897	Walker A/P-loop; other site
590409007898	ATP binding site [chemical binding]; other site
590409007899	Q-loop/lid; other site
590409007900	ABC transporter signature motif; other site
590409007901	Walker B; other site
590409007902	D-loop; other site
590409007903	H-loop/switch region; other site
590409007904	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
590409007905	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
590409007906	Walker A/P-loop; other site
590409007907	ATP binding site [chemical binding]; other site
590409007908	Q-loop/lid; other site
590409007909	ABC transporter signature motif; other site
590409007910	Walker B; other site
590409007911	D-loop; other site
590409007912	H-loop/switch region; other site
590409007913	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
590409007914	ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679
590409007915	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
590409007916	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
590409007917	Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568
590409007918	putative catalytic site [active]
590409007919	putative metal binding site [ion binding]; other site
590409007920	putative phosphate binding site [ion binding]; other site
590409007921	cardiolipin synthase 2; Provisional; Region: PRK11263
590409007922	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
590409007923	putative active site [active]
590409007924	catalytic site [active]
590409007925	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
590409007926	putative active site [active]
590409007927	catalytic site [active]
590409007928	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
590409007929	Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432
590409007930	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
590409007931	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
590409007932	Walker A/P-loop; other site
590409007933	ATP binding site [chemical binding]; other site
590409007934	Q-loop/lid; other site
590409007935	ABC transporter signature motif; other site
590409007936	Walker B; other site
590409007937	D-loop; other site
590409007938	H-loop/switch region; other site
590409007939	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
590409007940	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
590409007941	dimer interface [polypeptide binding]; other site
590409007942	conserved gate region; other site
590409007943	putative PBP binding loops; other site
590409007944	ABC-ATPase subunit interface; other site
590409007945	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
590409007946	dimer interface [polypeptide binding]; other site
590409007947	conserved gate region; other site
590409007948	putative PBP binding loops; other site
590409007949	ABC-ATPase subunit interface; other site
590409007950	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
590409007951	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
590409007952	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
590409007953	MoaE homodimer interface [polypeptide binding]; other site
590409007954	MoaD interaction [polypeptide binding]; other site
590409007955	active site residues [active]
590409007956	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
590409007957	MoaE interaction surface [polypeptide binding]; other site
590409007958	MoeB interaction surface [polypeptide binding]; other site
590409007959	thiocarboxylated glycine; other site
590409007960	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
590409007961	trimer interface [polypeptide binding]; other site
590409007962	dimer interface [polypeptide binding]; other site
590409007963	putative active site [active]
590409007964	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
590409007965	MPT binding site; other site
590409007966	trimer interface [polypeptide binding]; other site
590409007967	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
590409007968	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
590409007969	FeS/SAM binding site; other site
590409007970	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
590409007971	Protein of unknown function (DUF2474); Region: DUF2474; pfam10617
590409007972	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
590409007973	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
590409007974	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
590409007975	Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933
590409007976	family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187
590409007977	phosphate binding site [ion binding]; other site
590409007978	putative substrate binding pocket [chemical binding]; other site
590409007979	dimer interface [polypeptide binding]; other site
590409007980	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
590409007981	active site
590409007982	excinuclease ABC subunit B; Provisional; Region: PRK05298
590409007983	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
590409007984	ATP binding site [chemical binding]; other site
590409007985	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
590409007986	nucleotide binding region [chemical binding]; other site
590409007987	ATP-binding site [chemical binding]; other site
590409007988	Ultra-violet resistance protein B; Region: UvrB; pfam12344
590409007989	UvrB/uvrC motif; Region: UVR; pfam02151
590409007990	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
590409007991	AAA domain; Region: AAA_26; pfam13500
590409007992	biotin biosynthesis protein BioC; Region: BioC; TIGR02072
590409007993	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
590409007994	S-adenosylmethionine binding site [chemical binding]; other site
590409007995	8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958
590409007996	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
590409007997	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
590409007998	catalytic residue [active]
590409007999	biotin synthase; Provisional; Region: PRK15108
590409008000	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
590409008001	FeS/SAM binding site; other site
590409008002	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
590409008003	adenosylmethionine--8-amino-7-oxononanoate transaminase; Validated; Region: PRK07986
590409008004	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
590409008005	inhibitor-cofactor binding pocket; inhibition site
590409008006	pyridoxal 5'-phosphate binding site [chemical binding]; other site
590409008007	catalytic residue [active]
590409008008	Thermostable hemolysin; Region: T_hemolysin; pfam12261
590409008009	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
590409008010	AMP-binding enzyme; Region: AMP-binding; pfam00501
590409008011	acyl-activating enzyme (AAE) consensus motif; other site
590409008012	AMP binding site [chemical binding]; other site
590409008013	active site
590409008014	CoA binding site [chemical binding]; other site
590409008015	Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668
590409008016	P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583
590409008017	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
590409008018	Major Facilitator Superfamily; Region: MFS_1; pfam07690
590409008019	putative substrate translocation pore; other site
590409008020	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
590409008021	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
590409008022	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
590409008023	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
590409008024	hypothetical protein; Provisional; Region: PRK01821
590409008025	hypothetical protein; Provisional; Region: PRK10711
590409008026	cytidine deaminase; Provisional; Region: PRK09027
590409008027	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
590409008028	active site
590409008029	catalytic motif [active]
590409008030	Zn binding site [ion binding]; other site
590409008031	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
590409008032	active site
590409008033	catalytic motif [active]
590409008034	Zn binding site [ion binding]; other site
590409008035	malate dehydrogenase; Provisional; Region: PRK13529
590409008036	Malic enzyme, N-terminal domain; Region: malic; pfam00390
590409008037	NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312
590409008038	NAD(P) binding site [chemical binding]; other site
590409008039	molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK10680
590409008040	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
590409008041	dimer interface [polypeptide binding]; other site
590409008042	putative functional site; other site
590409008043	putative MPT binding site; other site
590409008044	molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690
590409008045	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
590409008046	ATP binding site [chemical binding]; other site
590409008047	substrate interface [chemical binding]; other site
590409008048	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
590409008049	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
590409008050	putative metal binding site; other site
590409008051	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
590409008052	binding surface
590409008053	TPR motif; other site
590409008054	Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895
590409008055	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
590409008056	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
590409008057	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
590409008058	Phage tail protein; Region: Sipho_tail; cl17486
590409008059	DgsA anti-repressor MtfA; Provisional; Region: PRK15410
590409008060	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
590409008061	Helix-turn-helix domain; Region: HTH_18; pfam12833
590409008062	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
590409008063	ornithine cyclodeaminase; Validated; Region: PRK06199
590409008064	Ornithine cyclodeaminase/mu-crystallin family; Region: OCD_Mu_crystall; pfam02423
590409008065	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154
590409008066	homotrimer interaction site [polypeptide binding]; other site
590409008067	putative active site [active]
590409008068	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
590409008069	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
590409008070	Transcriptional regulator [Transcription]; Region: LysR; COG0583
590409008071	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
590409008072	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
590409008073	dimerization interface [polypeptide binding]; other site
590409008074	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
590409008075	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
590409008076	NAD(P) binding site [chemical binding]; other site
590409008077	active site
590409008078	Transcriptional regulator [Transcription]; Region: LysR; COG0583
590409008079	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
590409008080	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
590409008081	dimerization interface [polypeptide binding]; other site
590409008082	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
590409008083	malonate decarboxylase, epsilon subunit; Region: malonate_mdcH; TIGR03131
590409008084	phosphoribosyl-dephospho-CoA transferase; Provisional; Region: PRK01293
590409008085	Phosphoribosyl-dephospho-CoA transferase MdcG; Region: MdcG; pfam10620
590409008086	Membrane transport protein; Region: Mem_trans; cl09117
590409008087	Malonate decarboxylase gamma subunit (MdcE); Region: MdcE; pfam06833
590409008088	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189
590409008089	Malonate decarboxylase delta subunit (MdcD); Region: ACP; cl06082
590409008090	ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; cl00768
590409008091	malonate decarboxylase, alpha subunit; Region: mdcA; TIGR01110
590409008092	Coenzyme A transferase; Region: CoA_trans; cl17247
590409008093	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
590409008094	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
590409008095	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
590409008096	active site
590409008097	phosphorylation site [posttranslational modification]
590409008098	intermolecular recognition site; other site
590409008099	dimerization interface [polypeptide binding]; other site
590409008100	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964
590409008101	YheO-like PAS domain; Region: PAS_6; pfam08348
590409008102	HTH domain; Region: HTH_22; pfam13309
590409008103	Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171
590409008104	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
590409008105	tetramer interface [polypeptide binding]; other site
590409008106	pyridoxal 5'-phosphate binding site [chemical binding]; other site
590409008107	catalytic residue [active]
590409008108	Alginate lyase; Region: Alginate_lyase; pfam05426
590409008109	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
590409008110	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
590409008111	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
590409008112	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
590409008113	Walker A/P-loop; other site
590409008114	ATP binding site [chemical binding]; other site
590409008115	Q-loop/lid; other site
590409008116	ABC transporter signature motif; other site
590409008117	Walker B; other site
590409008118	D-loop; other site
590409008119	H-loop/switch region; other site
590409008120	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
590409008121	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
590409008122	Walker A/P-loop; other site
590409008123	ATP binding site [chemical binding]; other site
590409008124	Q-loop/lid; other site
590409008125	ABC transporter signature motif; other site
590409008126	Walker B; other site
590409008127	D-loop; other site
590409008128	H-loop/switch region; other site
590409008129	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
590409008130	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
590409008131	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
590409008132	dimer interface [polypeptide binding]; other site
590409008133	conserved gate region; other site
590409008134	putative PBP binding loops; other site
590409008135	ABC-ATPase subunit interface; other site
590409008136	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
590409008137	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
590409008138	dimer interface [polypeptide binding]; other site
590409008139	conserved gate region; other site
590409008140	putative PBP binding loops; other site
590409008141	ABC-ATPase subunit interface; other site
590409008142	nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651
590409008143	active site
590409008144	tetramer interface [polypeptide binding]; other site
590409008145	nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651
590409008146	active site
590409008147	tetramer interface [polypeptide binding]; other site
590409008148	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
590409008149	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
590409008150	inhibitor site; inhibition site
590409008151	active site
590409008152	dimer interface [polypeptide binding]; other site
590409008153	catalytic residue [active]
590409008154	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
590409008155	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498
590409008156	DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013
590409008157	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
590409008158	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
590409008159	dimerization interface [polypeptide binding]; other site
590409008160	CDP-diacylglycerol pyrophosphatase; Provisional; Region: PRK05471
590409008161	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
590409008162	dimer interface [polypeptide binding]; other site
590409008163	conserved gate region; other site
590409008164	ABC-ATPase subunit interface; other site
590409008165	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
590409008166	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
590409008167	Walker A/P-loop; other site
590409008168	ATP binding site [chemical binding]; other site
590409008169	Q-loop/lid; other site
590409008170	ABC transporter signature motif; other site
590409008171	Walker B; other site
590409008172	D-loop; other site
590409008173	H-loop/switch region; other site
590409008174	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
590409008175	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
590409008176	Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491
590409008177	non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226
590409008178	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171
590409008179	Uncharacterized protein conserved in bacteria (DUF2076); Region: DUF2076; pfam09849
590409008180	Uncharacterized protein conserved in bacteria (DUF2076); Region: DUF2076; pfam09849
590409008181	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
590409008182	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
590409008183	metal binding site [ion binding]; metal-binding site
590409008184	active site
590409008185	I-site; other site
590409008186	disulfide isomerase/thiol-disulfide oxidase; Provisional; Region: dsbG; PRK11657
590409008187	DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020
590409008188	dimerization domain [polypeptide binding]; other site
590409008189	dimer interface [polypeptide binding]; other site
590409008190	catalytic residues [active]
590409008191	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
590409008192	Coenzyme A binding pocket [chemical binding]; other site
590409008193	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
590409008194	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
590409008195	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
590409008196	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
590409008197	Putative glucoamylase; Region: Glycoamylase; pfam10091
590409008198	Second GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_2_like; cd11753
590409008199	Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459
590409008200	First GH94N domain of cyclic beta 1-2 glucan synthetase and similar domains; Region: GH94N_ChvB_NdvB_1_like; cd11756
590409008201	C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cd02619
590409008202	active site
590409008203	galactoside permease; Reviewed; Region: lacY; PRK09528
590409008204	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
590409008205	putative substrate translocation pore; other site
590409008206	Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345
590409008207	Melibiase; Region: Melibiase; pfam02065
590409008208	Transcriptional regulators [Transcription]; Region: PurR; COG1609
590409008209	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
590409008210	DNA binding site [nucleotide binding]
590409008211	domain linker motif; other site
590409008212	Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271
590409008213	ligand binding site [chemical binding]; other site
590409008214	formate dehydrogenase-N subunit gamma; Provisional; Region: PRK10179
590409008215	formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583
590409008216	formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582
590409008217	Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163
590409008218	formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553
590409008219	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752
590409008220	[4Fe-4S] binding site [ion binding]; other site
590409008221	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
590409008222	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
590409008223	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792
590409008224	molybdopterin cofactor binding site; other site
590409008225	bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238
590409008226	Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576
590409008227	substrate binding site [chemical binding]; other site
590409008228	Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581
590409008229	substrate binding site [chemical binding]; other site
590409008230	ligand binding site [chemical binding]; other site
590409008231	Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase; Region: CitX; pfam03802
590409008232	Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051
590409008233	HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231
590409008234	citrate lyase subunit gamma; Provisional; Region: PRK13253
590409008235	Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053
590409008236	Citrate lyase ligase; Region: Citrate_lyase_ligase; cd02169
590409008237	putative active site [active]
590409008238	(T/H)XGH motif; other site
590409008239	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
590409008240	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
590409008241	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
590409008242	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
590409008243	putative substrate translocation pore; other site
590409008244	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2828
590409008245	Transcriptional regulator [Transcription]; Region: LysR; COG0583
590409008246	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
590409008247	TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440
590409008248	putative dimerization interface [polypeptide binding]; other site
590409008249	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
590409008250	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
590409008251	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
590409008252	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
590409008253	Divalent cation transporter; Region: MgtE; pfam01769
590409008254	magnesium transport protein MgtC; Provisional; Region: PRK15385
590409008255	MgtC family; Region: MgtC; pfam02308
590409008256	hypothetical protein; Validated; Region: PRK06201
590409008257	Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684
590409008258	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
590409008259	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
590409008260	Walker A/P-loop; other site
590409008261	ATP binding site [chemical binding]; other site
590409008262	Q-loop/lid; other site
590409008263	ABC transporter signature motif; other site
590409008264	Walker B; other site
590409008265	D-loop; other site
590409008266	H-loop/switch region; other site
590409008267	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
590409008268	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
590409008269	ABC-ATPase subunit  interface; other site
590409008270	dimer interface [polypeptide binding]; other site
590409008271	putative PBP binding regions; other site
590409008272	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
590409008273	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
590409008274	ABC-ATPase subunit  interface; other site
590409008275	dimer interface [polypeptide binding]; other site
590409008276	putative PBP binding regions; other site
590409008277	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
590409008278	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
590409008279	siderophore binding site; other site
590409008280	Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264
590409008281	IucA / IucC family; Region: IucA_IucC; pfam04183
590409008282	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
590409008283	HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231
590409008284	Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264
590409008285	IucA / IucC family; Region: IucA_IucC; pfam04183
590409008286	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
590409008287	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
590409008288	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
590409008289	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
590409008290	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme PvsE; Region: PLPDE_III_PvsE_like; cd06843
590409008291	dimer interface [polypeptide binding]; other site
590409008292	active site
590409008293	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
590409008294	catalytic residues [active]
590409008295	substrate binding site [chemical binding]; other site
590409008296	Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264
590409008297	IucA / IucC family; Region: IucA_IucC; pfam04183
590409008298	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
590409008299	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
590409008300	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
590409008301	N-terminal plug; other site
590409008302	ligand-binding site [chemical binding]; other site
590409008303	diaminobutyrate--2-oxoglutarate aminotransferase; Provisional; Region: PRK06931
590409008304	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
590409008305	inhibitor-cofactor binding pocket; inhibition site
590409008306	pyridoxal 5'-phosphate binding site [chemical binding]; other site
590409008307	catalytic residue [active]
590409008308	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
590409008309	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
590409008310	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
590409008311	dimer interface [polypeptide binding]; other site
590409008312	conserved gate region; other site
590409008313	putative PBP binding loops; other site
590409008314	ABC-ATPase subunit interface; other site
590409008315	phosphonate ABC transporter, periplasmic phosphonate binding protein; Region: PhnD; TIGR03431
590409008316	Transferrin; Region: Transferrin; cl02460
590409008317	ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638
590409008318	ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256
590409008319	Walker A/P-loop; other site
590409008320	ATP binding site [chemical binding]; other site
590409008321	Q-loop/lid; other site
590409008322	ABC transporter signature motif; other site
590409008323	Walker B; other site
590409008324	D-loop; other site
590409008325	H-loop/switch region; other site
590409008326	putative hydrolase; Provisional; Region: PRK02113
590409008327	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
590409008328	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
590409008329	AAA domain; Region: AAA_33; pfam13671
590409008330	active site
590409008331	phosphonate metabolism protein PhnM; Provisional; Region: PRK15446
590409008332	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
590409008333	PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306
590409008334	active site
590409008335	ABC-type phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PhnL; COG4778
590409008336	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
590409008337	Walker A/P-loop; other site
590409008338	ATP binding site [chemical binding]; other site
590409008339	Q-loop/lid; other site
590409008340	ABC transporter signature motif; other site
590409008341	Walker B; other site
590409008342	D-loop; other site
590409008343	H-loop/switch region; other site
590409008344	phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701
590409008345	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
590409008346	Walker A/P-loop; other site
590409008347	ATP binding site [chemical binding]; other site
590409008348	Q-loop/lid; other site
590409008349	ABC transporter signature motif; other site
590409008350	Walker B; other site
590409008351	D-loop; other site
590409008352	H-loop/switch region; other site
590409008353	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
590409008354	Phosphonate metabolism protein PhnJ; Region: PhnJ; pfam06007
590409008355	Bacterial phosphonate metabolism protein (PhnI); Region: PhnI; pfam05861
590409008356	carbon-phosphorus lyase complex subunit; Validated; Region: phnH; PRK10147
590409008357	Phosphonate metabolism protein PhnG; Region: PhnG; pfam06754
590409008358	phosphonate metabolism transcriptional regulator PhnF; Provisional; Region: PRK10079
590409008359	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
590409008360	DNA-binding site [nucleotide binding]; DNA binding site
590409008361	UTRA domain; Region: UTRA; pfam07702
590409008362	Transcriptional regulator [Transcription]; Region: LysR; COG0583
590409008363	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
590409008364	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
590409008365	putative effector binding pocket; other site
590409008366	dimerization interface [polypeptide binding]; other site
590409008367	short chain dehydrogenase; Provisional; Region: PRK06500
590409008368	classical (c) SDRs; Region: SDR_c; cd05233
590409008369	NAD(P) binding site [chemical binding]; other site
590409008370	active site
590409008371	Protein of unknown function (DUF3916); Region: DUF3916; pfam13079
590409008372	putrescine--2-oxoglutarate aminotransferase; Provisional; Region: PRK11522
590409008373	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
590409008374	inhibitor-cofactor binding pocket; inhibition site
590409008375	pyridoxal 5'-phosphate binding site [chemical binding]; other site
590409008376	catalytic residue [active]
590409008377	gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473
590409008378	Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092
590409008379	tetrameric interface [polypeptide binding]; other site
590409008380	NAD binding site [chemical binding]; other site
590409008381	catalytic residues [active]
590409008382	substrate binding site [chemical binding]; other site
590409008383	Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704
590409008384	anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK12489
590409008385	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
590409008386	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
590409008387	glutamate/aspartate:proton symporter; Provisional; Region: gltP; PRK11283
590409008388	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
590409008389	transcriptional regulator Cbl; Reviewed; Region: cbl; PRK12679
590409008390	The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413
590409008391	substrate binding site [chemical binding]; other site
590409008392	dimerization interface [polypeptide binding]; other site
590409008393	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
590409008394	hydrogenase 2 accessory protein HypG; Provisional; Region: PRK10413
590409008395	Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142
590409008396	4Fe-4S binding domain; Region: Fer4; pfam00037
590409008397	hydrogenase 4 subunit B; Validated; Region: PRK06521
590409008398	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
590409008399	NADH dehydrogenase; Region: NADHdh; cl00469
590409008400	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
590409008401	hydrogenase 4 subunit D; Validated; Region: PRK06525
590409008402	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
590409008403	hydrogenase 4 membrane subunit; Provisional; Region: hyfE; PRK11492
590409008404	hydrogenase 4 subunit F; Validated; Region: PRK06458
590409008405	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
590409008406	Ni,Fe-hydrogenase III component G [Energy production and conversion]; Region: HycE; COG3262
590409008407	NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338
590409008408	Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261
590409008409	hydrogenase 4 subunit H; Validated; Region: PRK08222
590409008410	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
590409008411	Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260
590409008412	formate hydrogenlyase maturation protein HycH; Provisional; Region: PRK15084
590409008413	coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130
590409008414	Endopeptidases belonging to membrane-bound hydrogen evolving hydrogenase group. In hydrogenase 3 from E coli, the maturation of the large subunit (HycE) requires the cleavage of a C-terminal peptide by the endopeptidase HycI, before the final formation...; Region: H2MP_MemB-H2evol; cd06067
590409008415	nickel binding site [ion binding]; other site
590409008416	Protein of unknown function (DUF2442); Region: DUF2442; pfam10387
590409008417	Predicted transcriptional regulator [Transcription]; Region: COG3636; cl17681
590409008418	formate dehydrogenase-H ferredoxin subunit; Provisional; Region: PRK10330
590409008419	4Fe-4S binding domain; Region: Fer4; cl02805
590409008420	Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753
590409008421	formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591
590409008422	[4Fe-4S] binding site [ion binding]; other site
590409008423	molybdopterin cofactor binding site; other site
590409008424	Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790
590409008425	molybdopterin cofactor binding site; other site
590409008426	formate hydrogenlyase transcriptional activator FhlA; Provisional; Region: PRK15429
590409008427	GAF domain; Region: GAF_3; pfam13492
590409008428	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
590409008429	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
590409008430	Walker A motif; other site
590409008431	ATP binding site [chemical binding]; other site
590409008432	Walker B motif; other site
590409008433	arginine finger; other site
590409008434	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
590409008435	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
590409008436	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
590409008437	cell density-dependent motility repressor; Provisional; Region: PRK10082
590409008438	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
590409008439	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
590409008440	dimerization interface [polypeptide binding]; other site
590409008441	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
590409008442	aspartate racemase; Region: asp_race; TIGR00035
590409008443	lac repressor; Reviewed; Region: lacI; PRK09526
590409008444	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
590409008445	DNA binding site [nucleotide binding]
590409008446	domain linker motif; other site
590409008447	Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574
590409008448	ligand binding site [chemical binding]; other site
590409008449	dimerization interface (open form) [polypeptide binding]; other site
590409008450	dimerization interface (closed form) [polypeptide binding]; other site
590409008451	beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525
590409008452	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
590409008453	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
590409008454	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
590409008455	Beta galactosidase small chain; Region: Bgal_small_N; pfam02929
590409008456	integrase; Provisional; Region: PRK09692
590409008457	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
590409008458	active site
590409008459	Int/Topo IB signature motif; other site
590409008460	twin arginine translocase protein E; Validated; Region: tatE; PRK03625
590409008461	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
590409008462	Esterase/lipase [General function prediction only]; Region: COG1647
590409008463	Protein of unknown function (DUF1330); Region: DUF1330; cl02288
590409008464	Transcriptional regulator [Transcription]; Region: LysR; COG0583
590409008465	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
590409008466	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474
590409008467	putative effector binding pocket; other site
590409008468	putative dimerization interface [polypeptide binding]; other site
590409008469	heavy metal response regulator; Region: cztR_silR_copR; TIGR01387
590409008470	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
590409008471	active site
590409008472	phosphorylation site [posttranslational modification]
590409008473	intermolecular recognition site; other site
590409008474	dimerization interface [polypeptide binding]; other site
590409008475	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
590409008476	DNA binding site [nucleotide binding]
590409008477	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
590409008478	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
590409008479	dimer interface [polypeptide binding]; other site
590409008480	phosphorylation site [posttranslational modification]
590409008481	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
590409008482	ATP binding site [chemical binding]; other site
590409008483	Mg2+ binding site [ion binding]; other site
590409008484	G-X-G motif; other site
590409008485	Protein of unknown function (DUF1471); Region: DUF1471; cl11507
590409008486	Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073
590409008487	flavodoxin; Provisional; Region: PRK06934
590409008488	Domain of unknown function (DUF4405); Region: DUF4405; pfam14358
590409008489	Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249
590409008490	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
590409008491	clavulanic acid dehydrogenase (CAD), classical (c) SDR; Region: CAD_SDR_c; cd08934
590409008492	NADP binding site [chemical binding]; other site
590409008493	homotetramer interface [polypeptide binding]; other site
590409008494	homodimer interface [polypeptide binding]; other site
590409008495	active site
590409008496	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
590409008497	Old yellow enzyme (OYE)-related FMN binding domain, group 4.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735
590409008498	putative active site [active]
590409008499	putative FMN binding site [chemical binding]; other site
590409008500	putative substrate binding site [chemical binding]; other site
590409008501	putative catalytic residue [active]
590409008502	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
590409008503	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276
590409008504	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
590409008505	putative NAD(P) binding site [chemical binding]; other site
590409008506	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
590409008507	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
590409008508	active site
590409008509	catalytic tetrad [active]
590409008510	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
590409008511	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
590409008512	Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525
590409008513	AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719
590409008514	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
590409008515	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
590409008516	Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311
590409008517	Protein of unknown function (DUF2857); Region: DUF2857; pfam11198
590409008518	phage/conjugal plasmid C-4 type zinc finger protein, TraR family; Region: C4_traR_proteo; TIGR02419
590409008519	Transcriptional regulator [Transcription]; Region: LysR; COG0583
590409008520	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
590409008521	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
590409008522	dimerization interface [polypeptide binding]; other site
590409008523	EamA-like transporter family; Region: EamA; pfam00892
590409008524	EamA-like transporter family; Region: EamA; pfam00892
590409008525	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
590409008526	N-acetyl-D-glucosamine binding site [chemical binding]; other site
590409008527	catalytic residue [active]
590409008528	TrbC/VIRB2 family; Region: TrbC; pfam04956
590409008529	Type IV secretory pathway, VirB3-like protein; Region: VirB3; cl01501
590409008530	type IV secretion/conjugal transfer ATPase, VirB4 family; Region: VirB4_CagE; TIGR00929
590409008531	CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135
590409008532	P-type DNA transfer protein VirB5; Region: VirB5; TIGR02791
590409008533	Type IV secretion system proteins; Region: T4SS; pfam07996
590409008534	TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; pfam04610
590409008535	VirB8 protein; Region: VirB8; pfam04335
590409008536	VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cl11423
590409008537	VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911
590409008538	VirB7 interaction site; other site
590409008539	Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743
590409008540	P-type DNA transfer ATPase VirB11; Region: VirB11; TIGR02788
590409008541	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
590409008542	Walker A motif; other site
590409008543	hexamer interface [polypeptide binding]; other site
590409008544	ATP binding site [chemical binding]; other site
590409008545	Walker B motif; other site
590409008546	Cag pathogenicity island protein Cag12; Region: Cag12; pfam13117
590409008547	TrbM; Region: TrbM; pfam07424
590409008548	Type IV secretory system Conjugative DNA transfer; Region: T4SS-DNA_transf; pfam02534
590409008549	TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375
590409008550	Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227
590409008551	Domain of unknown function (DUF1738); Region: DUF1738; pfam08401
590409008552	DEAD/DEAH box helicase; Region: DEAD; pfam00270
590409008553	ATP binding site [chemical binding]; other site
590409008554	putative Mg++ binding site [ion binding]; other site
590409008555	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
590409008556	nucleotide binding region [chemical binding]; other site
590409008557	ATP-binding site [chemical binding]; other site
590409008558	Domain of unknown function (DUF4297); Region: DUF4297; pfam14130
590409008559	Domain of unknown function (DUF1837); Region: DUF1837; pfam08878
590409008560	short chain dehydrogenase; Provisional; Region: PRK06500
590409008561	classical (c) SDRs; Region: SDR_c; cd05233
590409008562	NAD(P) binding site [chemical binding]; other site
590409008563	active site
590409008564	Stress responsive A/B Barrel Domain; Region: Dabb; pfam07876
590409008565	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
590409008566	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283
590409008567	putative NAD(P) binding site [chemical binding]; other site
590409008568	putative substrate binding site [chemical binding]; other site
590409008569	catalytic Zn binding site [ion binding]; other site
590409008570	structural Zn binding site [ion binding]; other site
590409008571	dimer interface [polypeptide binding]; other site
590409008572	Transcriptional regulator [Transcription]; Region: LysR; COG0583
590409008573	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
590409008574	putative effector binding pocket; other site
590409008575	dimerization interface [polypeptide binding]; other site
590409008576	Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819
590409008577	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
590409008578	homodimer interface [polypeptide binding]; other site
590409008579	active site
590409008580	TDP-binding site; other site
590409008581	acceptor substrate-binding pocket; other site
590409008582	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
590409008583	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
590409008584	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
590409008585	Tar ligand binding domain homologue; Region: TarH; pfam02203
590409008586	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
590409008587	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
590409008588	dimerization interface [polypeptide binding]; other site
590409008589	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
590409008590	dimer interface [polypeptide binding]; other site
590409008591	putative CheW interface [polypeptide binding]; other site
590409008592	Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062
590409008593	putative dimer interface [polypeptide binding]; other site
590409008594	catalytic triad [active]
590409008595	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
590409008596	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
590409008597	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
590409008598	substrate binding pocket [chemical binding]; other site
590409008599	dimerization interface [polypeptide binding]; other site
590409008600	putative aminotransferase; Provisional; Region: PRK12414
590409008601	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
590409008602	pyridoxal 5'-phosphate binding site [chemical binding]; other site
590409008603	homodimer interface [polypeptide binding]; other site
590409008604	catalytic residue [active]
590409008605	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
590409008606	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
590409008607	substrate binding pocket [chemical binding]; other site
590409008608	membrane-bound complex binding site; other site
590409008609	hinge residues; other site
590409008610	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
590409008611	Predicted flavoprotein [General function prediction only]; Region: COG0431
590409008612	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
590409008613	active site
590409008614	SAM binding site [chemical binding]; other site
590409008615	homodimer interface [polypeptide binding]; other site
590409008616	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
590409008617	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
590409008618	[4Fe-4S] binding site [ion binding]; other site
590409008619	molybdopterin cofactor binding site; other site
590409008620	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791
590409008621	molybdopterin cofactor binding site; other site
590409008622	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
590409008623	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
590409008624	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
590409008625	nitrite reductase subunit NirD; Provisional; Region: PRK14989
590409008626	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
590409008627	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
590409008628	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
590409008629	Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529
590409008630	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
590409008631	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
590409008632	Walker A/P-loop; other site
590409008633	ATP binding site [chemical binding]; other site
590409008634	Q-loop/lid; other site
590409008635	ABC transporter signature motif; other site
590409008636	Walker B; other site
590409008637	D-loop; other site
590409008638	H-loop/switch region; other site
590409008639	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
590409008640	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
590409008641	dimer interface [polypeptide binding]; other site
590409008642	conserved gate region; other site
590409008643	putative PBP binding loops; other site
590409008644	ABC-ATPase subunit interface; other site
590409008645	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
590409008646	NMT1-like family; Region: NMT1_2; pfam13379
590409008647	Nitrate and nitrite sensing; Region: NIT; pfam08376
590409008648	ANTAR domain; Region: ANTAR; pfam03861
590409008649	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
590409008650	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
590409008651	Protein export membrane protein; Region: SecD_SecF; cl14618
590409008652	multidrug efflux system transporter AcrA; Provisional; Region: PRK15030
590409008653	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
590409008654	HlyD family secretion protein; Region: HlyD_3; pfam13437
590409008655	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
590409008656	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
590409008657	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
590409008658	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
590409008659	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
590409008660	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
590409008661	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
590409008662	formate dehydrogenase accessory protein FdhE; Provisional; Region: PRK03564
590409008663	formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562
590409008664	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
590409008665	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
590409008666	putative substrate translocation pore; other site
590409008667	formate dehydrogenase-O subunit gamma; Provisional; Region: PRK10639
590409008668	formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583
590409008669	formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582
590409008670	Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163
590409008671	formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553
590409008672	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752
590409008673	[4Fe-4S] binding site [ion binding]; other site
590409008674	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
590409008675	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752
590409008676	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792
590409008677	molybdopterin cofactor binding site; other site
590409008678	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
590409008679	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
590409008680	DNA-binding site [nucleotide binding]; DNA binding site
590409008681	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
590409008682	pyridoxal 5'-phosphate binding site [chemical binding]; other site
590409008683	homodimer interface [polypeptide binding]; other site
590409008684	catalytic residue [active]
590409008685	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
590409008686	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
590409008687	catalytic triad [active]
590409008688	sigma70 family sigma factor YlaC; Region: YlaC; pfam10777
590409008689	Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068
590409008690	Acylphosphatase; Region: Acylphosphatase; pfam00708
590409008691	HypF finger; Region: zf-HYPF; pfam07503
590409008692	HypF finger; Region: zf-HYPF; pfam07503
590409008693	Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300
590409008694	HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis.  HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197
590409008695	dimerization interface [polypeptide binding]; other site
590409008696	hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124
590409008697	ATP binding site [chemical binding]; other site
590409008698	hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062
590409008699	hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075
590409008700	hydrogenase 2 accessory protein HypG; Provisional; Region: PRK10413
590409008701	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
590409008702	Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375
590409008703	Hydrogenase expression/synthesis hypA family; Region: HypA; cl17671
590409008704	hydrogenase 2-specific chaperone; Provisional; Region: PRK10465
590409008705	Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062
590409008706	nickel binding site [ion binding]; other site
590409008707	putative substrate-binding site; other site
590409008708	hydrogenase 2 large subunit; Provisional; Region: PRK10467
590409008709	Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374
590409008710	putative hydrogenase 2 b cytochrome subunit; Provisional; Region: PRK10881
590409008711	Polysulphide reductase, NrfD; Region: NrfD; pfam03916
590409008712	hydrogenase 2 protein HybA; Provisional; Region: PRK10882
590409008713	4Fe-4S binding domain; Region: Fer4_6; pfam12837
590409008714	hydrogenase 2 small subunit; Provisional; Region: PRK10468
590409008715	Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409
590409008716	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058
590409008717	ABC transporter ATP-binding protein; Provisional; Region: PRK15064
590409008718	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
590409008719	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
590409008720	Walker A/P-loop; other site
590409008721	ATP binding site [chemical binding]; other site
590409008722	ABC transporter signature motif; other site
590409008723	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
590409008724	Walker B; other site
590409008725	ABC transporter; Region: ABC_tran_2; pfam12848
590409008726	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
590409008727	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
590409008728	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
590409008729	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
590409008730	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
590409008731	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
590409008732	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
590409008733	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
590409008734	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
590409008735	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
590409008736	NADH:ubiquinone oxidoreductase subunit 6 (chain J) [Energy production and conversion]; Region: NuoJ; COG0839
590409008737	NADH dehydrogenase subunit J; Provisional; Region: PRK06433
590409008738	NADH dehydrogenase subunit I; Provisional; Region: PRK05888
590409008739	4Fe-4S binding domain; Region: Fer4; cl02805
590409008740	4Fe-4S binding domain; Region: Fer4; pfam00037
590409008741	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
590409008742	NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) [Energy production and conversion]; Region: NuoG; COG1034
590409008743	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
590409008744	catalytic loop [active]
590409008745	iron binding site [ion binding]; other site
590409008746	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
590409008747	MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771
590409008748	[4Fe-4S] binding site [ion binding]; other site
590409008749	MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788
590409008750	NADH dehydrogenase I subunit F; Provisional; Region: PRK11278
590409008751	SLBB domain; Region: SLBB; pfam10531
590409008752	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589
590409008753	NADH dehydrogenase subunit E; Validated; Region: PRK07539
590409008754	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
590409008755	putative dimer interface [polypeptide binding]; other site
590409008756	[2Fe-2S] cluster binding site [ion binding]; other site
590409008757	bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742
590409008758	NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961
590409008759	NADH dehydrogenase subunit D; Validated; Region: PRK06075
590409008760	NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377
590409008761	NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602
590409008762	DNA-binding transcriptional repressor LrhA; Provisional; Region: PRK15092
590409008763	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
590409008764	The C-terminal substrate domain of LysR-like regulator LrhA (LysR homologue A) and that of closely related homologs, contains the type 2 periplasmic binding fold; Region: PBP2_LrhA_like; cd08439
590409008765	putative dimerization interface [polypeptide binding]; other site
590409008766	aminotransferase AlaT; Validated; Region: PRK09265
590409008767	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
590409008768	pyridoxal 5'-phosphate binding site [chemical binding]; other site
590409008769	homodimer interface [polypeptide binding]; other site
590409008770	catalytic residue [active]
590409008771	5'-nucleotidase; Provisional; Region: PRK03826
590409008772	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
590409008773	transmembrane helices; other site
590409008774	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
590409008775	TrkA-C domain; Region: TrkA_C; pfam02080
590409008776	TrkA-C domain; Region: TrkA_C; pfam02080
590409008777	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
590409008778	putative phosphatase; Provisional; Region: PRK11587
590409008779	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
590409008780	motif II; other site
590409008781	hypothetical protein; Validated; Region: PRK05445
590409008782	hypothetical protein; Provisional; Region: PRK01816
590409008783	propionate/acetate kinase; Provisional; Region: PRK12379
590409008784	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
590409008785	phosphate acetyltransferase; Reviewed; Region: PRK05632
590409008786	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
590409008787	DRTGG domain; Region: DRTGG; pfam07085
590409008788	phosphate acetyltransferase; Region: pta; TIGR00651
590409008789	NUDIX hydrolase YfcD; Provisional; Region: PRK15393
590409008790	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
590409008791	nudix motif; other site
590409008792	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
590409008793	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
590409008794	active site
590409008795	metal binding site [ion binding]; metal-binding site
590409008796	homotetramer interface [polypeptide binding]; other site
590409008797	GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972
590409008798	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
590409008799	C-terminal domain interface [polypeptide binding]; other site
590409008800	GSH binding site (G-site) [chemical binding]; other site
590409008801	dimer interface [polypeptide binding]; other site
590409008802	C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291
590409008803	N-terminal domain interface [polypeptide binding]; other site
590409008804	putative dimer interface [polypeptide binding]; other site
590409008805	active site
590409008806	Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090
590409008807	atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242
590409008808	putative NAD(P) binding site [chemical binding]; other site
590409008809	putative active site [active]
590409008810	histidine/lysine/arginine/ornithine transporter subunit; Provisional; Region: PRK10619
590409008811	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
590409008812	Walker A/P-loop; other site
590409008813	ATP binding site [chemical binding]; other site
590409008814	Q-loop/lid; other site
590409008815	ABC transporter signature motif; other site
590409008816	Walker B; other site
590409008817	D-loop; other site
590409008818	H-loop/switch region; other site
590409008819	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
590409008820	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
590409008821	dimer interface [polypeptide binding]; other site
590409008822	conserved gate region; other site
590409008823	putative PBP binding loops; other site
590409008824	ABC-ATPase subunit interface; other site
590409008825	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
590409008826	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
590409008827	dimer interface [polypeptide binding]; other site
590409008828	conserved gate region; other site
590409008829	putative PBP binding loops; other site
590409008830	ABC-ATPase subunit interface; other site
590409008831	histidine ABC transporter substrate-binding protein HisJ; Provisional; Region: PRK15437
590409008832	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
590409008833	substrate binding pocket [chemical binding]; other site
590409008834	membrane-bound complex binding site; other site
590409008835	hinge residues; other site
590409008836	3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029
590409008837	Flavoprotein; Region: Flavoprotein; pfam02441
590409008838	amidophosphoribosyltransferase; Provisional; Region: PRK09246
590409008839	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
590409008840	active site
590409008841	tetramer interface [polypeptide binding]; other site
590409008842	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
590409008843	active site
590409008844	Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286
590409008845	colicin V production protein; Provisional; Region: PRK10845
590409008846	cell division protein DedD; Provisional; Region: PRK11633
590409008847	Sporulation related domain; Region: SPOR; pfam05036
590409008848	bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846
590409008849	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
590409008850	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
590409008851	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
590409008852	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
590409008853	hypothetical protein; Provisional; Region: PRK10847
590409008854	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
590409008855	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
590409008856	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
590409008857	dimerization interface 3.5A [polypeptide binding]; other site
590409008858	active site
590409008859	putative semialdehyde dehydrogenase; Provisional; Region: PRK08040
590409008860	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
590409008861	erythronate-4-phosphate dehydrogenase PdxB; Provisional; Region: PRK15438
590409008862	D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158
590409008863	ligand binding site [chemical binding]; other site
590409008864	NAD binding site [chemical binding]; other site
590409008865	catalytic site [active]
590409008866	homodimer interface [polypeptide binding]; other site
590409008867	Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521
590409008868	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
590409008869	dimer interface [polypeptide binding]; other site
590409008870	phosphorylation site [posttranslational modification]
590409008871	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
590409008872	ATP binding site [chemical binding]; other site
590409008873	G-X-G motif; other site
590409008874	transcriptional regulatory protein TctD; Provisional; Region: PRK15479
590409008875	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
590409008876	active site
590409008877	phosphorylation site [posttranslational modification]
590409008878	intermolecular recognition site; other site
590409008879	dimerization interface [polypeptide binding]; other site
590409008880	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
590409008881	DNA binding site [nucleotide binding]
590409008882	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
590409008883	Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331
590409008884	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333
590409008885	flagella biosynthesis regulator; Provisional; Region: flk; PRK10715
590409008886	3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967
590409008887	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
590409008888	dimer interface [polypeptide binding]; other site
590409008889	active site
590409008890	bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747
590409008891	Uncharacterized conserved protein [Function unknown]; Region: COG4121
590409008892	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
590409008893	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
590409008894	HAMP domain; Region: HAMP; pfam00672
590409008895	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
590409008896	dimer interface [polypeptide binding]; other site
590409008897	putative CheW interface [polypeptide binding]; other site
590409008898	GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046
590409008899	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
590409008900	putative C-terminal domain interface [polypeptide binding]; other site
590409008901	putative GSH binding site (G-site) [chemical binding]; other site
590409008902	putative dimer interface [polypeptide binding]; other site
590409008903	C-terminal, alpha helical domain of GTT1-like Glutathione S-transferases; Region: GST_C_GTT1_like; cd03189
590409008904	putative N-terminal domain interface [polypeptide binding]; other site
590409008905	putative dimer interface [polypeptide binding]; other site
590409008906	putative substrate binding pocket (H-site) [chemical binding]; other site
590409008907	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
590409008908	Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141
590409008909	potential catalytic triad [active]
590409008910	conserved cys residue [active]
590409008911	Coniferyl aldehyde dehydrogenase-like; Region: ALDH_CALDH_CalB; cd07133
590409008912	NAD(P) binding site [chemical binding]; other site
590409008913	catalytic residues [active]
590409008914	Transcriptional regulator [Transcription]; Region: LysR; COG0583
590409008915	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
590409008916	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
590409008917	dimerization interface [polypeptide binding]; other site
590409008918	YfcL protein; Region: YfcL; pfam08891
590409008919	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3101
590409008920	hypothetical protein; Provisional; Region: PRK10621
590409008921	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
590409008922	penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429
590409008923	Murein endopeptidase [Cell envelope biogenesis, outer membrane]; Region: MepA; COG3770
590409008924	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
590409008925	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
590409008926	Tetramer interface [polypeptide binding]; other site
590409008927	active site
590409008928	FMN-binding site [chemical binding]; other site
590409008929	HemK family putative methylases; Region: hemK_fam; TIGR00536
590409008930	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
590409008931	S-adenosylmethionine binding site [chemical binding]; other site
590409008932	hypothetical protein; Provisional; Region: PRK04946
590409008933	Smr domain; Region: Smr; pfam01713
590409008934	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
590409008935	catalytic core [active]
590409008936	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154
590409008937	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
590409008938	substrate binding site [chemical binding]; other site
590409008939	oxyanion hole (OAH) forming residues; other site
590409008940	trimer interface [polypeptide binding]; other site
590409008941	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
590409008942	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
590409008943	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
590409008944	3-ketoacyl-CoA thiolase; Reviewed; Region: fadI; PRK08963
590409008945	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
590409008946	dimer interface [polypeptide binding]; other site
590409008947	active site
590409008948	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3691
590409008949	long-chain fatty acid outer membrane transporter; Provisional; Region: PRK10716
590409008950	malate:quinone oxidoreductase; Validated; Region: PRK05257
590409008951	malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320
590409008952	ABC transporter outer membrane lipoprotein; Provisional; Region: PRK15091
590409008953	Necrosis inducing protein (NPP1); Region: NPP1; pfam05630
590409008954	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
590409008955	active site
590409008956	motif I; other site
590409008957	motif II; other site
590409008958	Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485
590409008959	iron-enterobactin transporter periplasmic binding protein; Provisional; Region: PRK10957
590409008960	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
590409008961	siderophore binding site; other site
590409008962	enterobactin exporter EntS; Provisional; Region: PRK10489
590409008963	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
590409008964	putative substrate translocation pore; other site
590409008965	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
590409008966	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
590409008967	ABC-ATPase subunit  interface; other site
590409008968	dimer interface [polypeptide binding]; other site
590409008969	putative PBP binding regions; other site
590409008970	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
590409008971	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
590409008972	ABC-ATPase subunit  interface; other site
590409008973	dimer interface [polypeptide binding]; other site
590409008974	putative PBP binding regions; other site
590409008975	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
590409008976	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
590409008977	Walker A/P-loop; other site
590409008978	ATP binding site [chemical binding]; other site
590409008979	Q-loop/lid; other site
590409008980	ABC transporter signature motif; other site
590409008981	Walker B; other site
590409008982	D-loop; other site
590409008983	H-loop/switch region; other site
590409008984	Condensation domain; Region: Condensation; pfam00668
590409008985	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
590409008986	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
590409008987	acyl-activating enzyme (AAE) consensus motif; other site
590409008988	AMP binding site [chemical binding]; other site
590409008989	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
590409008990	Condensation domain; Region: Condensation; pfam00668
590409008991	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
590409008992	Condensation domain; Region: Condensation; pfam00668
590409008993	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
590409008994	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
590409008995	acyl-activating enzyme (AAE) consensus motif; other site
590409008996	AMP binding site [chemical binding]; other site
590409008997	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
590409008998	Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319
590409008999	MbtH-like protein; Region: MbtH; cl01279
590409009000	enterobactin/ferric enterobactin esterase; Provisional; Region: PRK10439
590409009001	Domain of unknown function (DUF3327); Region: DUF3327; pfam11806
590409009002	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
590409009003	ferrichrome outer membrane transporter; Provisional; Region: PRK10044
590409009004	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
590409009005	N-terminal plug; other site
590409009006	ligand-binding site [chemical binding]; other site
590409009007	isochorismate synthase EntC; Provisional; Region: PRK15016
590409009008	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
590409009009	enterobactin synthase subunit E; Provisional; Region: entE; PRK10946
590409009010	2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920
590409009011	acyl-activating enzyme (AAE) consensus motif; other site
590409009012	active site
590409009013	AMP binding site [chemical binding]; other site
590409009014	substrate binding site [chemical binding]; other site
590409009015	Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013
590409009016	hydrophobic substrate binding pocket; other site
590409009017	Isochorismatase family; Region: Isochorismatase; pfam00857
590409009018	active site
590409009019	conserved cis-peptide bond; other site
590409009020	Phosphopantetheine attachment site; Region: PP-binding; cl09936
590409009021	2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220
590409009022	2,3 dihydro-2,3 dihydrozybenzoate dehydrogenases, classical (c) SDRs; Region: DH-DHB-DH_SDR_c; cd05331
590409009023	putative NAD(P) binding site [chemical binding]; other site
590409009024	active site
590409009025	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
590409009026	CoenzymeA binding site [chemical binding]; other site
590409009027	subunit interaction site [polypeptide binding]; other site
590409009028	PHB binding site; other site
590409009029	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
590409009030	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
590409009031	FMN binding site [chemical binding]; other site
590409009032	active site
590409009033	substrate binding site [chemical binding]; other site
590409009034	catalytic residue [active]
590409009035	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
590409009036	Serine hydrolase; Region: Ser_hydrolase; pfam06821
590409009037	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
590409009038	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
590409009039	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
590409009040	Type II secretion system (T2SS), protein M; Region: T2SM; pfam04612
590409009041	type II secretion system protein L; Region: typeII_sec_gspL; TIGR01709
590409009042	Type II secretion system (T2SS), protein L; Region: T2SL; pfam05134
590409009043	GspL periplasmic domain; Region: GspL_C; pfam12693
590409009044	Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934
590409009045	Type II secretory pathway, component PulJ [Intracellular trafficking and secretion]; Region: PulJ; COG4795
590409009046	Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612
590409009047	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
590409009048	type II secretion system protein I; Region: gspI; TIGR01707
590409009049	Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501
590409009050	type II secretion system protein H; Region: typeII_sec_gspH; TIGR01708
590409009051	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
590409009052	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
590409009053	type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710
590409009054	Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334
590409009055	type II secretion system protein F; Region: GspF; TIGR02120
590409009056	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
590409009057	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
590409009058	type II secretion system protein E; Region: type_II_gspE; TIGR02533
590409009059	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
590409009060	Walker A motif; other site
590409009061	ATP binding site [chemical binding]; other site
590409009062	Walker B motif; other site
590409009063	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
590409009064	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
590409009065	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
590409009066	pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519
590409009067	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
590409009068	type II secretion system protein C; Region: typeII_sec_gspC; TIGR01713
590409009069	Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356
590409009070	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117
590409009071	lipoprotein, PulS/OutS family; Region: PulS_OutS; TIGR01004
590409009072	aminotransferase; Validated; Region: PRK08175
590409009073	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
590409009074	pyridoxal 5'-phosphate binding site [chemical binding]; other site
590409009075	homodimer interface [polypeptide binding]; other site
590409009076	catalytic residue [active]
590409009077	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
590409009078	D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558
590409009079	homodimer interface [polypeptide binding]; other site
590409009080	substrate-cofactor binding pocket; other site
590409009081	pyridoxal 5'-phosphate binding site [chemical binding]; other site
590409009082	catalytic residue [active]
590409009083	Protein of unknown function (DUF3772); Region: DUF3772; pfam12607
590409009084	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
590409009085	Mechanosensitive ion channel; Region: MS_channel; pfam00924
590409009086	integrase; Provisional; Region: PRK09692
590409009087	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
590409009088	active site
590409009089	Int/Topo IB signature motif; other site
590409009090	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
590409009091	DNA-binding interface [nucleotide binding]; DNA binding site
590409009092	HTH-like domain; Region: HTH_21; pfam13276
590409009093	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
590409009094	Integrase core domain; Region: rve; pfam00665
590409009095	Integrase core domain; Region: rve_3; pfam13683
590409009096	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
590409009097	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
590409009098	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
590409009099	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
590409009100	tetramerization interface [polypeptide binding]; other site
590409009101	NAD(P) binding site [chemical binding]; other site
590409009102	catalytic residues [active]
590409009103	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
590409009104	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
590409009105	active site
590409009106	catalytic tetrad [active]
590409009107	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
590409009108	NAD(P) binding site [chemical binding]; other site
590409009109	active site
590409009110	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
590409009111	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
590409009112	Transcriptional regulator [Transcription]; Region: LysR; COG0583
590409009113	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
590409009114	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
590409009115	putative effector binding pocket; other site
590409009116	dimerization interface [polypeptide binding]; other site
590409009117	Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979
590409009118	Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187
590409009119	dimer interface [polypeptide binding]; other site
590409009120	active site
590409009121	metal binding site [ion binding]; metal-binding site
590409009122	Membrane transport protein; Region: Mem_trans; cl09117
590409009123	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
590409009124	putative substrate translocation pore; other site
590409009125	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
590409009126	Domain of unknown function (DUF4405); Region: DUF4405; pfam14358
590409009127	Uncharacterized enzymes similar to novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like-3; cd12810
590409009128	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
590409009129	catalytic site [active]
590409009130	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
590409009131	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
590409009132	active site
590409009133	catalytic tetrad [active]
590409009134	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
590409009135	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
590409009136	active site
590409009137	catalytic tetrad [active]
590409009138	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
590409009139	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283
590409009140	putative NAD(P) binding site [chemical binding]; other site
590409009141	putative substrate binding site [chemical binding]; other site
590409009142	catalytic Zn binding site [ion binding]; other site
590409009143	structural Zn binding site [ion binding]; other site
590409009144	dimer interface [polypeptide binding]; other site
590409009145	Protein of unknown function (DUF1471); Region: DUF1471; pfam07338
590409009146	DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219
590409009147	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
590409009148	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
590409009149	multidrug efflux system transporter AcrA; Provisional; Region: PRK15030
590409009150	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
590409009151	HlyD family secretion protein; Region: HlyD_3; pfam13437
590409009152	multidrug efflux system protein AcrB; Provisional; Region: PRK15127
590409009153	Protein export membrane protein; Region: SecD_SecF; cl14618
590409009154	Transcriptional regulator [Transcription]; Region: LysR; COG0583
590409009155	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
590409009156	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474
590409009157	putative effector binding pocket; other site
590409009158	putative dimerization interface [polypeptide binding]; other site
590409009159	atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
590409009160	NADH(P)-binding; Region: NAD_binding_10; pfam13460
590409009161	NAD(P) binding site [chemical binding]; other site
590409009162	putative active site [active]
590409009163	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
590409009164	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
590409009165	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
590409009166	short chain dehydrogenase; Provisional; Region: PRK06940
590409009167	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
590409009168	NAD(P) binding site [chemical binding]; other site
590409009169	active site
590409009170	HTH-like domain; Region: HTH_21; pfam13276
590409009171	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
590409009172	Integrase core domain; Region: rve; pfam00665
590409009173	Integrase core domain; Region: rve_3; pfam13683
590409009174	Transposase; Region: DEDD_Tnp_IS110; pfam01548
590409009175	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
590409009176	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
590409009177	Transposase; Region: HTH_Tnp_1; cl17663
590409009178	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
590409009179	SnoaL-like domain; Region: SnoaL_4; pfam13577
590409009180	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
590409009181	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
590409009182	metal binding site [ion binding]; metal-binding site
590409009183	active site
590409009184	I-site; other site
590409009185	Protein of unknown function (DUF3313); Region: DUF3313; pfam11769
590409009186	Paraquat-inducible protein A; Region: PqiA; pfam04403
590409009187	Paraquat-inducible protein A; Region: PqiA; pfam04403
590409009188	Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008
590409009189	mce related protein; Region: MCE; pfam02470
590409009190	mce related protein; Region: MCE; pfam02470
590409009191	mce related protein; Region: MCE; pfam02470
590409009192	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009
590409009193	Protein of unknown function (DUF330); Region: DUF330; pfam03886
590409009194	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
590409009195	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
590409009196	AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246
590409009197	Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311
590409009198	Protein of unknown function (DUF3279); Region: DUF3279; pfam11682
590409009199	Protein of unknown function (DUF3296); Region: DUF3296; pfam11726
590409009200	Predicted GTPase [General function prediction only]; Region: COG3596
590409009201	YfjP GTPase; Region: YfjP; cd11383
590409009202	G1 box; other site
590409009203	GTP/Mg2+ binding site [chemical binding]; other site
590409009204	Switch I region; other site
590409009205	G2 box; other site
590409009206	Switch II region; other site
590409009207	G3 box; other site
590409009208	G4 box; other site
590409009209	G5 box; other site
590409009210	Domain of unknown function (DUF932); Region: DUF932; pfam06067
590409009211	Predicted transcriptional regulator [Transcription]; Region: COG2378
590409009212	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
590409009213	WYL domain; Region: WYL; pfam13280
590409009214	Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018
590409009215	Type V secretory pathway, adhesin AidA [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: AidA; COG3468
590409009216	hypothetical protein; Provisional; Region: PRK09945
590409009217	Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344
590409009218	outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414
590409009219	Autotransporter beta-domain; Region: Autotransporter; pfam03797
590409009220	Protein of unknown function (DUF3732); Region: DUF3732; pfam12532
590409009221	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
590409009222	MPN+ (JAMM) motif; other site
590409009223	Zinc-binding site [ion binding]; other site
590409009224	Inhibitor of vertebrate lysozyme (Ivy); Region: Ivy; cl07428
590409009225	YagB/YeeU/YfjZ family; Region: YagB_YeeU_YfjZ; pfam06154
590409009226	Protein of unknown function (DUF1219); Region: DUF1219; pfam06755
590409009227	Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468
590409009228	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
590409009229	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
590409009230	Walker A/P-loop; other site
590409009231	ATP binding site [chemical binding]; other site
590409009232	Q-loop/lid; other site
590409009233	ABC transporter signature motif; other site
590409009234	Walker B; other site
590409009235	D-loop; other site
590409009236	H-loop/switch region; other site
590409009237	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
590409009238	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
590409009239	Walker A/P-loop; other site
590409009240	ATP binding site [chemical binding]; other site
590409009241	Q-loop/lid; other site
590409009242	ABC transporter signature motif; other site
590409009243	Walker B; other site
590409009244	D-loop; other site
590409009245	H-loop/switch region; other site
590409009246	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
590409009247	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
590409009248	TM-ABC transporter signature motif; other site
590409009249	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
590409009250	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
590409009251	TM-ABC transporter signature motif; other site
590409009252	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
590409009253	Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268
590409009254	ligand binding site [chemical binding]; other site
590409009255	Transcriptional regulators [Transcription]; Region: GntR; COG1802
590409009256	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
590409009257	DNA-binding site [nucleotide binding]; DNA binding site
590409009258	FCD domain; Region: FCD; pfam07729
590409009259	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
590409009260	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666
590409009261	metal binding site [ion binding]; metal-binding site
590409009262	putative dimer interface [polypeptide binding]; other site
590409009263	Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345
590409009264	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
590409009265	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
590409009266	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
590409009267	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
590409009268	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
590409009269	Walker A/P-loop; other site
590409009270	ATP binding site [chemical binding]; other site
590409009271	Q-loop/lid; other site
590409009272	ABC transporter signature motif; other site
590409009273	Walker B; other site
590409009274	D-loop; other site
590409009275	H-loop/switch region; other site
590409009276	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
590409009277	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
590409009278	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
590409009279	Walker A/P-loop; other site
590409009280	ATP binding site [chemical binding]; other site
590409009281	Q-loop/lid; other site
590409009282	ABC transporter signature motif; other site
590409009283	Walker B; other site
590409009284	D-loop; other site
590409009285	H-loop/switch region; other site
590409009286	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
590409009287	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
590409009288	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
590409009289	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
590409009290	dimer interface [polypeptide binding]; other site
590409009291	conserved gate region; other site
590409009292	putative PBP binding loops; other site
590409009293	ABC-ATPase subunit interface; other site
590409009294	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
590409009295	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
590409009296	dimer interface [polypeptide binding]; other site
590409009297	conserved gate region; other site
590409009298	putative PBP binding loops; other site
590409009299	ABC-ATPase subunit interface; other site
590409009300	LuxR family transcriptional regulatory, chaperone HchA-associated; Region: reg_near_HchA; TIGR03541
590409009301	Autoinducer binding domain; Region: Autoind_bind; pfam03472
590409009302	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
590409009303	DNA binding residues [nucleotide binding]
590409009304	dimerization interface [polypeptide binding]; other site
590409009305	proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250
590409009306	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
590409009307	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
590409009308	metal binding site [ion binding]; metal-binding site
590409009309	active site
590409009310	I-site; other site
590409009311	Hemerythrin; Region: Hemerythrin; cd12107
590409009312	Fe binding site [ion binding]; other site
590409009313	Predicted transporter component [General function prediction only]; Region: COG2391
590409009314	Sulphur transport; Region: Sulf_transp; pfam04143
590409009315	Predicted transporter component [General function prediction only]; Region: COG2391
590409009316	Domain of unknown function (DUF4341); Region: DUF4341; pfam14241
590409009317	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
590409009318	dimerization interface [polypeptide binding]; other site
590409009319	putative DNA binding site [nucleotide binding]; other site
590409009320	putative Zn2+ binding site [ion binding]; other site
590409009321	Uncharacterized conserved protein [Function unknown]; Region: COG2850
590409009322	Putative motility protein; Region: YjfB_motility; pfam14070
590409009323	lac repressor; Reviewed; Region: lacI; PRK09526
590409009324	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
590409009325	DNA binding site [nucleotide binding]
590409009326	domain linker motif; other site
590409009327	Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574
590409009328	ligand binding site [chemical binding]; other site
590409009329	dimerization interface (open form) [polypeptide binding]; other site
590409009330	dimerization interface (closed form) [polypeptide binding]; other site
590409009331	The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346
590409009332	trimer interface; other site
590409009333	sugar binding site [chemical binding]; other site
590409009334	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
590409009335	active site turn [active]
590409009336	phosphorylation site [posttranslational modification]
590409009337	Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874
590409009338	Beta-galactosidase; Region: Glyco_hydro_42; pfam02449
590409009339	A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143
590409009340	Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533
590409009341	Glycosyl hydrolase family 53; Region: Glyco_hydro_53; cl06672
590409009342	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
590409009343	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
590409009344	dimer interface [polypeptide binding]; other site
590409009345	conserved gate region; other site
590409009346	putative PBP binding loops; other site
590409009347	ABC-ATPase subunit interface; other site
590409009348	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
590409009349	dimer interface [polypeptide binding]; other site
590409009350	conserved gate region; other site
590409009351	ABC-ATPase subunit interface; other site
590409009352	Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182
590409009353	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
590409009354	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
590409009355	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
590409009356	Walker A/P-loop; other site
590409009357	ATP binding site [chemical binding]; other site
590409009358	Q-loop/lid; other site
590409009359	ABC transporter signature motif; other site
590409009360	Walker B; other site
590409009361	D-loop; other site
590409009362	H-loop/switch region; other site
590409009363	TOBE domain; Region: TOBE_2; pfam08402
590409009364	Pectate lyase; Region: Pectate_lyase; pfam03211
590409009365	Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371
590409009366	Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172
590409009367	putative active site [active]
590409009368	metal binding site [ion binding]; metal-binding site
590409009369	bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072
590409009370	The starvation sensing protein RpsA from E.coli and its homologs are lactonizing enzymes whose putative targets are homoserine lactone (HSL)-derivative. They are part of the mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of...; Region: rpsA; cd03322
590409009371	putative active site pocket [active]
590409009372	putative metal binding site [ion binding]; other site
590409009373	Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904
590409009374	Glucuronate isomerase; Region: UxaC; pfam02614
590409009375	Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211
590409009376	Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246
590409009377	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
590409009378	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
590409009379	Transcriptional regulators [Transcription]; Region: GntR; COG1802
590409009380	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
590409009381	DNA-binding site [nucleotide binding]; DNA binding site
590409009382	FCD domain; Region: FCD; pfam07729
590409009383	urocanate hydratase; Provisional; Region: PRK05414
590409009384	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
590409009385	active sites [active]
590409009386	tetramer interface [polypeptide binding]; other site
590409009387	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
590409009388	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
590409009389	Walker A/P-loop; other site
590409009390	ATP binding site [chemical binding]; other site
590409009391	Q-loop/lid; other site
590409009392	ABC transporter signature motif; other site
590409009393	Walker B; other site
590409009394	D-loop; other site
590409009395	H-loop/switch region; other site
590409009396	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
590409009397	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
590409009398	dimer interface [polypeptide binding]; other site
590409009399	conserved gate region; other site
590409009400	putative PBP binding loops; other site
590409009401	ABC-ATPase subunit interface; other site
590409009402	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
590409009403	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
590409009404	substrate binding pocket [chemical binding]; other site
590409009405	membrane-bound complex binding site; other site
590409009406	hinge residues; other site
590409009407	Flagellin N-methylase; Region: FliB; pfam03692
590409009408	histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018
590409009409	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
590409009410	DNA-binding site [nucleotide binding]; DNA binding site
590409009411	UTRA domain; Region: UTRA; pfam07702
590409009412	PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451
590409009413	Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290
590409009414	PAS domain; Region: PAS; smart00091
590409009415	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
590409009416	ATP binding site [chemical binding]; other site
590409009417	Mg2+ binding site [ion binding]; other site
590409009418	G-X-G motif; other site
590409009419	Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565
590409009420	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
590409009421	active site
590409009422	phosphorylation site [posttranslational modification]
590409009423	intermolecular recognition site; other site
590409009424	dimerization interface [polypeptide binding]; other site
590409009425	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
590409009426	active sites [active]
590409009427	tetramer interface [polypeptide binding]; other site
590409009428	ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598
590409009429	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
590409009430	Walker A/P-loop; other site
590409009431	ATP binding site [chemical binding]; other site
590409009432	Q-loop/lid; other site
590409009433	ABC transporter signature motif; other site
590409009434	Walker B; other site
590409009435	D-loop; other site
590409009436	H-loop/switch region; other site
590409009437	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
590409009438	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
590409009439	dimer interface [polypeptide binding]; other site
590409009440	conserved gate region; other site
590409009441	putative PBP binding loops; other site
590409009442	ABC-ATPase subunit interface; other site
590409009443	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
590409009444	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
590409009445	dimer interface [polypeptide binding]; other site
590409009446	conserved gate region; other site
590409009447	putative PBP binding loops; other site
590409009448	ABC-ATPase subunit interface; other site
590409009449	lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096
590409009450	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
590409009451	substrate binding pocket [chemical binding]; other site
590409009452	membrane-bound complex binding site; other site
590409009453	hinge residues; other site
590409009454	HutD; Region: HutD; pfam05962
590409009455	N-formimino-L-glutamate deiminase; Validated; Region: PRK09229
590409009456	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
590409009457	active site
590409009458	imidazolonepropionase; Validated; Region: PRK09356
590409009459	Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296
590409009460	active site
590409009461	N-formylglutamate amidohydrolase; Region: FGase; cl01522
590409009462	Nitrate and nitrite sensing; Region: NIT; pfam08376
590409009463	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
590409009464	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
590409009465	dimer interface [polypeptide binding]; other site
590409009466	putative CheW interface [polypeptide binding]; other site
590409009467	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792
590409009468	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
590409009469	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
590409009470	homodimer interface [polypeptide binding]; other site
590409009471	NADP binding site [chemical binding]; other site
590409009472	substrate binding site [chemical binding]; other site
590409009473	ribosome-associated protein; Provisional; Region: PRK11507
590409009474	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
590409009475	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
590409009476	active site
590409009477	HIGH motif; other site
590409009478	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
590409009479	KMSKS motif; other site
590409009480	Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963
590409009481	tRNA binding surface [nucleotide binding]; other site
590409009482	anticodon binding site; other site
590409009483	DoxX; Region: DoxX; pfam07681
590409009484	cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920
590409009485	substrate binding site [chemical binding]; other site
590409009486	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
590409009487	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
590409009488	putative active site [active]
590409009489	putative metal binding site [ion binding]; other site
590409009490	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
590409009491	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
590409009492	ATP-grasp domain; Region: ATP-grasp; pfam02222
590409009493	Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814
590409009494	serine transporter; Region: stp; TIGR00814
590409009495	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
590409009496	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
590409009497	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
590409009498	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
590409009499	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
590409009500	non-specific DNA binding site [nucleotide binding]; other site
590409009501	salt bridge; other site
590409009502	sequence-specific DNA binding site [nucleotide binding]; other site
590409009503	phosphate transporter ATP-binding protein; Provisional; Region: PRK14236
590409009504	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
590409009505	Walker A/P-loop; other site
590409009506	ATP binding site [chemical binding]; other site
590409009507	Q-loop/lid; other site
590409009508	ABC transporter signature motif; other site
590409009509	Walker B; other site
590409009510	D-loop; other site
590409009511	H-loop/switch region; other site
590409009512	ABC-type phosphate transport system, auxiliary component [Inorganic ion transport and metabolism]; Region: COG4985
590409009513	phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974
590409009514	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
590409009515	ABC-ATPase subunit interface; other site
590409009516	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4590
590409009517	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
590409009518	ABC-ATPase subunit interface; other site
590409009519	polyphosphate kinase; Provisional; Region: PRK05443
590409009520	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
590409009521	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
590409009522	Catalytic C-terminal domain, first repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C1_like; cd09164
590409009523	domain interface [polypeptide binding]; other site
590409009524	active site
590409009525	catalytic site [active]
590409009526	Catalytic C-terminal domain, second repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C2_like; cd09167
590409009527	domain interface [polypeptide binding]; other site
590409009528	active site
590409009529	catalytic site [active]
590409009530	exopolyphosphatase; Provisional; Region: PRK10854
590409009531	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
590409009532	nucleotide binding site [chemical binding]; other site
590409009533	Protein of unknown function (DUF2633); Region: DUF2633; pfam11119
590409009534	hypothetical protein; Provisional; Region: PRK11019
590409009535	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
590409009536	Ligand Binding Site [chemical binding]; other site
590409009537	Domain of unknown function (DUF4186); Region: DUF4186; pfam13811
590409009538	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220
590409009539	Isochorismatase family; Region: Isochorismatase; pfam00857
590409009540	catalytic triad [active]
590409009541	conserved cis-peptide bond; other site
590409009542	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
590409009543	YccA-like proteins; Region: YccA_like; cd10433
590409009544	Predicted transcriptional regulators [Transcription]; Region: COG1733
590409009545	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
590409009546	short chain dehydrogenase; Provisional; Region: PRK06500
590409009547	classical (c) SDRs; Region: SDR_c; cd05233
590409009548	NAD(P) binding site [chemical binding]; other site
590409009549	active site
590409009550	Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920
590409009551	sulfur relay protein, TusE/DsrC/DsvC family; Region: dsrC_tusE_dsvC; TIGR03342
590409009552	acylphosphatase; Provisional; Region: PRK14426
590409009553	heat shock protein HspQ; Provisional; Region: PRK14129
590409009554	Predicted CoA-binding protein [General function prediction only]; Region: COG1832
590409009555	hypothetical protein; Provisional; Region: PRK03641
590409009556	Uncharacterized protein conserved in bacteria (DUF2057); Region: DUF2057; cl11437
590409009557	Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422
590409009558	active site
590409009559	dimer interfaces [polypeptide binding]; other site
590409009560	catalytic residues [active]
590409009561	DNA helicase IV; Provisional; Region: helD; PRK11054
590409009562	DNA helicase IV / RNA helicase N terminal; Region: Nucleolin_N; pfam12462
590409009563	Part of AAA domain; Region: AAA_19; pfam13245
590409009564	Family description; Region: UvrD_C_2; pfam13538
590409009565	hypothetical protein; Provisional; Region: PRK11770
590409009566	Domain of unknown function (DUF307); Region: DUF307; pfam03733
590409009567	Domain of unknown function (DUF307); Region: DUF307; pfam03733
590409009568	TIGR01666 family membrane protein; Region: YCCS
590409009569	FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805
590409009570	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
590409009571	TfoX N-terminal domain; Region: TfoX_N; pfam04993
590409009572	TfoX C-terminal domain; Region: TfoX_C; pfam04994
590409009573	SOS cell division inhibitor; Provisional; Region: PRK10595
590409009574	outer membrane protein A; Reviewed; Region: PRK10808
590409009575	OmpA-like transmembrane domain; Region: OmpA_membrane; pfam01389
590409009576	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
590409009577	ligand binding site [chemical binding]; other site
590409009578	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
590409009579	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
590409009580	active site
590409009581	catalytic tetrad [active]
590409009582	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
590409009583	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
590409009584	Nucleoside recognition; Region: Gate; pfam07670
590409009585	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
590409009586	multidrug efflux system subunit MdtA; Provisional; Region: PRK11556
590409009587	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
590409009588	HlyD family secretion protein; Region: HlyD_3; pfam13437
590409009589	multidrug efflux system subunit MdtB; Provisional; Region: PRK10503
590409009590	Protein export membrane protein; Region: SecD_SecF; cl14618
590409009591	multidrug efflux system subunit MdtC; Provisional; Region: PRK10614
590409009592	putative transporter; Provisional; Region: PRK10504
590409009593	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
590409009594	putative substrate translocation pore; other site
590409009595	signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549
590409009596	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
590409009597	dimerization interface [polypeptide binding]; other site
590409009598	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
590409009599	dimer interface [polypeptide binding]; other site
590409009600	phosphorylation site [posttranslational modification]
590409009601	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
590409009602	ATP binding site [chemical binding]; other site
590409009603	Mg2+ binding site [ion binding]; other site
590409009604	G-X-G motif; other site
590409009605	DNA-binding transcriptional regulator BaeR; Provisional; Region: PRK10710
590409009606	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
590409009607	active site
590409009608	phosphorylation site [posttranslational modification]
590409009609	intermolecular recognition site; other site
590409009610	dimerization interface [polypeptide binding]; other site
590409009611	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
590409009612	DNA binding site [nucleotide binding]
590409009613	Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435
590409009614	C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190
590409009615	putative dimer interface [polypeptide binding]; other site
590409009616	N-terminal domain interface [polypeptide binding]; other site
590409009617	putative substrate binding pocket (H-site) [chemical binding]; other site
590409009618	putative protease; Provisional; Region: PRK15452
590409009619	Peptidase family U32; Region: Peptidase_U32; pfam01136
590409009620	phosphate-starvation-inducible protein PsiE; Provisional; Region: PRK02833
590409009621	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
590409009622	dimer interface [polypeptide binding]; other site
590409009623	substrate binding site [chemical binding]; other site
590409009624	ATP binding site [chemical binding]; other site
590409009625	4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170
590409009626	substrate binding site [chemical binding]; other site
590409009627	multimerization interface [polypeptide binding]; other site
590409009628	ATP binding site [chemical binding]; other site
590409009629	Transcriptional regulator [Transcription]; Region: LysR; COG0583
590409009630	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
590409009631	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
590409009632	dimerization interface [polypeptide binding]; other site
590409009633	Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961
590409009634	Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038
590409009635	dimer interface [polypeptide binding]; other site
590409009636	PYR/PP interface [polypeptide binding]; other site
590409009637	TPP binding site [chemical binding]; other site
590409009638	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
590409009639	Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005
590409009640	TPP-binding site [chemical binding]; other site
590409009641	dimer interface [polypeptide binding]; other site
590409009642	Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168
590409009643	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
590409009644	pyridoxal 5'-phosphate binding site [chemical binding]; other site
590409009645	homodimer interface [polypeptide binding]; other site
590409009646	catalytic residue [active]
590409009647	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
590409009648	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
590409009649	putative substrate translocation pore; other site
590409009650	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
590409009651	Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192
590409009652	Carbamoyltransferase; Region: CmcH_NodU; pfam02543
590409009653	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
590409009654	S-adenosylmethionine binding site [chemical binding]; other site
590409009655	DNA-binding transcriptional repressor LrhA; Provisional; Region: PRK15092
590409009656	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
590409009657	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
590409009658	dimerization interface [polypeptide binding]; other site
590409009659	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
590409009660	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
590409009661	hexamer interface [polypeptide binding]; other site
590409009662	active site 2 [active]
590409009663	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262
590409009664	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
590409009665	Protein of unknown function (DUF3750); Region: DUF3750; pfam12570
590409009666	Major Facilitator Superfamily; Region: MFS_1; pfam07690
590409009667	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
590409009668	putative substrate translocation pore; other site
590409009669	Uncharacterized conserved protein [Function unknown]; Region: COG3287
590409009670	FIST N domain; Region: FIST; pfam08495
590409009671	FIST C domain; Region: FIST_C; pfam10442
590409009672	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
590409009673	ATP binding site [chemical binding]; other site
590409009674	Mg2+ binding site [ion binding]; other site
590409009675	G-X-G motif; other site
590409009676	Response regulator receiver domain; Region: Response_reg; pfam00072
590409009677	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
590409009678	active site
590409009679	phosphorylation site [posttranslational modification]
590409009680	intermolecular recognition site; other site
590409009681	dimerization interface [polypeptide binding]; other site
590409009682	HDOD domain; Region: HDOD; pfam08668
590409009683	Response regulator receiver domain; Region: Response_reg; pfam00072
590409009684	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
590409009685	active site
590409009686	phosphorylation site [posttranslational modification]
590409009687	intermolecular recognition site; other site
590409009688	dimerization interface [polypeptide binding]; other site
590409009689	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215
590409009690	transcriptional regulator MirA; Provisional; Region: PRK15043
590409009691	Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104
590409009692	DNA binding residues [nucleotide binding]
590409009693	SnoaL-like domain; Region: SnoaL_2; pfam12680
590409009694	short chain dehydrogenase; Provisional; Region: PRK06101
590409009695	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
590409009696	NAD(P) binding site [chemical binding]; other site
590409009697	active site
590409009698	Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907
590409009699	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
590409009700	Protein of unknown function (DUF1365); Region: DUF1365; pfam07103
590409009701	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
590409009702	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
590409009703	S-adenosylmethionine binding site [chemical binding]; other site
590409009704	Protein of unknown function (DUF3833); Region: DUF3833; pfam12915
590409009705	Protein of unknown function (DUF523); Region: DUF523; pfam04463
590409009706	Uncharacterized conserved protein [Function unknown]; Region: COG3272
590409009707	Protein of unknown function (DUF1722); Region: DUF1722; cl01284
590409009708	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884
590409009709	active site clefts [active]
590409009710	zinc binding site [ion binding]; other site
590409009711	dimer interface [polypeptide binding]; other site
590409009712	Phospholipase/lecithinase/hemolysin [Lipid metabolism / General function prediction only]; Region: COG3240
590409009713	Triacylglycerol lipase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: Triacylglycerol_lipase_like; cd01847
590409009714	active site
590409009715	catalytic triad [active]
590409009716	oxyanion hole [active]
590409009717	Autotransporter beta-domain; Region: Autotransporter; smart00869
590409009718	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
590409009719	active site
590409009720	Condensation domain; Region: Condensation; pfam00668
590409009721	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
590409009722	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
590409009723	acyl-activating enzyme (AAE) consensus motif; other site
590409009724	AMP binding site [chemical binding]; other site
590409009725	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
590409009726	Condensation domain; Region: Condensation; pfam00668
590409009727	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
590409009728	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
590409009729	acyl-activating enzyme (AAE) consensus motif; other site
590409009730	AMP binding site [chemical binding]; other site
590409009731	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
590409009732	Condensation domain; Region: Condensation; pfam00668
590409009733	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
590409009734	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
590409009735	acyl-activating enzyme (AAE) consensus motif; other site
590409009736	AMP binding site [chemical binding]; other site
590409009737	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
590409009738	Condensation domain; Region: Condensation; pfam00668
590409009739	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
590409009740	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
590409009741	acyl-activating enzyme (AAE) consensus motif; other site
590409009742	AMP binding site [chemical binding]; other site
590409009743	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
590409009744	Condensation domain; Region: Condensation; pfam00668
590409009745	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
590409009746	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
590409009747	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
590409009748	acyl-activating enzyme (AAE) consensus motif; other site
590409009749	AMP binding site [chemical binding]; other site
590409009750	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
590409009751	Condensation domain; Region: Condensation; pfam00668
590409009752	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
590409009753	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
590409009754	acyl-activating enzyme (AAE) consensus motif; other site
590409009755	AMP binding site [chemical binding]; other site
590409009756	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
590409009757	Condensation domain; Region: Condensation; pfam00668
590409009758	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
590409009759	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
590409009760	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
590409009761	acyl-activating enzyme (AAE) consensus motif; other site
590409009762	AMP binding site [chemical binding]; other site
590409009763	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
590409009764	Condensation domain; Region: Condensation; pfam00668
590409009765	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
590409009766	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
590409009767	acyl-activating enzyme (AAE) consensus motif; other site
590409009768	AMP binding site [chemical binding]; other site
590409009769	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
590409009770	Condensation domain; Region: Condensation; pfam00668
590409009771	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
590409009772	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
590409009773	acyl-activating enzyme (AAE) consensus motif; other site
590409009774	AMP binding site [chemical binding]; other site
590409009775	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
590409009776	Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319
590409009777	Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319
590409009778	multidrug transporter membrane component/ATP-binding component; Provisional; Region: PRK10522
590409009779	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
590409009780	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
590409009781	Walker A/P-loop; other site
590409009782	ATP binding site [chemical binding]; other site
590409009783	Q-loop/lid; other site
590409009784	ABC transporter signature motif; other site
590409009785	Walker B; other site
590409009786	D-loop; other site
590409009787	H-loop/switch region; other site
590409009788	GMP synthase; Reviewed; Region: guaA; PRK00074
590409009789	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
590409009790	AMP/PPi binding site [chemical binding]; other site
590409009791	candidate oxyanion hole; other site
590409009792	catalytic triad [active]
590409009793	potential glutamine specificity residues [chemical binding]; other site
590409009794	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
590409009795	ATP Binding subdomain [chemical binding]; other site
590409009796	Ligand Binding sites [chemical binding]; other site
590409009797	Dimerization subdomain; other site
590409009798	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
590409009799	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
590409009800	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
590409009801	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
590409009802	active site
590409009803	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
590409009804	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
590409009805	generic binding surface II; other site
590409009806	generic binding surface I; other site
590409009807	Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227
590409009808	Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597
590409009809	active site
590409009810	Zn binding site [ion binding]; other site
590409009811	Protein of unknown function (DUF1407); Region: DUF1407; pfam07191
590409009812	GTP-binding protein Der; Reviewed; Region: PRK00093
590409009813	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
590409009814	G1 box; other site
590409009815	GTP/Mg2+ binding site [chemical binding]; other site
590409009816	Switch I region; other site
590409009817	G2 box; other site
590409009818	Switch II region; other site
590409009819	G3 box; other site
590409009820	G4 box; other site
590409009821	G5 box; other site
590409009822	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
590409009823	G1 box; other site
590409009824	GTP/Mg2+ binding site [chemical binding]; other site
590409009825	Switch I region; other site
590409009826	G2 box; other site
590409009827	G3 box; other site
590409009828	Switch II region; other site
590409009829	G4 box; other site
590409009830	G5 box; other site
590409009831	outer membrane biogenesis protein BamB; Provisional; Region: PRK11138
590409009832	Beta-barrel assembly machinery (Bam) complex component B and related proteins; Region: BamB_YfgL; cd10276
590409009833	Trp docking motif [polypeptide binding]; other site
590409009834	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976
590409009835	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
590409009836	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
590409009837	dimer interface [polypeptide binding]; other site
590409009838	motif 1; other site
590409009839	active site
590409009840	motif 2; other site
590409009841	motif 3; other site
590409009842	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
590409009843	anticodon binding site; other site
590409009844	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
590409009845	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
590409009846	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
590409009847	cytoskeletal protein RodZ; Provisional; Region: PRK10856
590409009848	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
590409009849	non-specific DNA binding site [nucleotide binding]; other site
590409009850	salt bridge; other site
590409009851	sequence-specific DNA binding site [nucleotide binding]; other site
590409009852	Domain of unknown function (DUF4115); Region: DUF4115; pfam13464
590409009853	type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521
590409009854	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
590409009855	binding surface
590409009856	TPR motif; other site
590409009857	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194
590409009858	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
590409009859	FeS/SAM binding site; other site
590409009860	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
590409009861	active site
590409009862	multimer interface [polypeptide binding]; other site
590409009863	3-mercaptopyruvate sulfurtransferase; Provisional; Region: sseA; PRK11493
590409009864	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
590409009865	active site residue [active]
590409009866	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
590409009867	active site residue [active]
590409009868	enhanced serine sensitivity protein SseB; Provisional; Region: PRK11611
590409009869	aminopeptidase B; Provisional; Region: PRK05015
590409009870	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
590409009871	interface (dimer of trimers) [polypeptide binding]; other site
590409009872	Substrate-binding/catalytic site; other site
590409009873	Zn-binding sites [ion binding]; other site
590409009874	hypothetical protein; Provisional; Region: PRK10721
590409009875	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
590409009876	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
590409009877	catalytic loop [active]
590409009878	iron binding site [ion binding]; other site
590409009879	chaperone protein HscA; Provisional; Region: hscA; PRK05183
590409009880	Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236
590409009881	nucleotide binding site [chemical binding]; other site
590409009882	putative NEF/HSP70 interaction site [polypeptide binding]; other site
590409009883	SBD interface [polypeptide binding]; other site
590409009884	co-chaperone HscB; Provisional; Region: hscB; PRK05014
590409009885	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
590409009886	HSP70 interaction site [polypeptide binding]; other site
590409009887	HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743
590409009888	iron-sulfur cluster assembly protein; Provisional; Region: iscA; PRK09502
590409009889	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
590409009890	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
590409009891	trimerization site [polypeptide binding]; other site
590409009892	active site
590409009893	cysteine desulfurase; Provisional; Region: PRK14012
590409009894	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
590409009895	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
590409009896	catalytic residue [active]
590409009897	DNA-binding transcriptional regulator IscR; Provisional; Region: PRK10857
590409009898	Rrf2 family protein; Region: rrf2_super; TIGR00738
590409009899	tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ; Provisional; Region: PRK15114
590409009900	SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307
590409009901	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
590409009902	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
590409009903	active site
590409009904	dimerization interface [polypeptide binding]; other site
590409009905	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
590409009906	intersubunit interface [polypeptide binding]; other site
590409009907	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
590409009908	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
590409009909	dimer interface [polypeptide binding]; other site
590409009910	putative PBP binding regions; other site
590409009911	ABC-ATPase subunit  interface; other site
590409009912	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
590409009913	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
590409009914	Walker A/P-loop; other site
590409009915	ATP binding site [chemical binding]; other site
590409009916	Q-loop/lid; other site
590409009917	ABC transporter signature motif; other site
590409009918	Walker B; other site
590409009919	D-loop; other site
590409009920	H-loop/switch region; other site
590409009921	ferrichrome/ferrioxamine B periplasmic transporter; Provisional; Region: PRK14048
590409009922	Periplasmic binding protein TroA_f.  These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea.  They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_f; cd01139
590409009923	putative ligand binding residues [chemical binding]; other site
590409009924	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG2215
590409009925	Protein of unknown function (DUF1007); Region: DUF1007; pfam06226
590409009926	putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128
590409009927	MFS_1 like family; Region: MFS_1_like; pfam12832
590409009928	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
590409009929	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
590409009930	dimer interface [polypeptide binding]; other site
590409009931	active site
590409009932	glycine-pyridoxal phosphate binding site [chemical binding]; other site
590409009933	folate binding site [chemical binding]; other site
590409009934	bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289
590409009935	Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
590409009936	heme-binding site [chemical binding]; other site
590409009937	FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184
590409009938	FAD binding pocket [chemical binding]; other site
590409009939	FAD binding motif [chemical binding]; other site
590409009940	phosphate binding motif [ion binding]; other site
590409009941	beta-alpha-beta structure motif; other site
590409009942	NAD binding pocket [chemical binding]; other site
590409009943	Heme binding  pocket [chemical binding]; other site
590409009944	Pectate lyase [Carbohydrate transport and metabolism]; Region: PelB; COG3866
590409009945	Pectate lyase; Region: Pec_lyase_C; pfam00544
590409009946	Pectate lyase; Region: Pec_lyase_C; pfam00544
590409009947	Pectate lyase; Region: Pec_lyase_C; pfam00544
590409009948	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
590409009949	active site
590409009950	catalytic triad [active]
590409009951	oxyanion hole [active]
590409009952	Pectinesterase; Region: Pectinesterase; pfam01095
590409009953	putative pectinesterase; Region: PLN02432; cl01911
590409009954	nitrogen regulatory protein P-II 1; Provisional; Region: PRK10858
590409009955	Nitrogen regulatory protein P-II; Region: P-II; smart00938
590409009956	response regulator GlrR; Provisional; Region: PRK15115
590409009957	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
590409009958	active site
590409009959	phosphorylation site [posttranslational modification]
590409009960	intermolecular recognition site; other site
590409009961	dimerization interface [polypeptide binding]; other site
590409009962	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
590409009963	Walker A motif; other site
590409009964	ATP binding site [chemical binding]; other site
590409009965	Walker B motif; other site
590409009966	arginine finger; other site
590409009967	hypothetical protein; Provisional; Region: PRK10722
590409009968	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
590409009969	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
590409009970	dimer interface [polypeptide binding]; other site
590409009971	phosphorylation site [posttranslational modification]
590409009972	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
590409009973	ATP binding site [chemical binding]; other site
590409009974	Mg2+ binding site [ion binding]; other site
590409009975	G-X-G motif; other site
590409009976	phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297
590409009977	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
590409009978	dimerization interface [polypeptide binding]; other site
590409009979	ATP binding site [chemical binding]; other site
590409009980	AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019
590409009981	dimerization interface [polypeptide binding]; other site
590409009982	ATP binding site [chemical binding]; other site
590409009983	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
590409009984	putative active site [active]
590409009985	catalytic triad [active]
590409009986	membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859
590409009987	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
590409009988	substrate binding pocket [chemical binding]; other site
590409009989	membrane-bound complex binding site; other site
590409009990	hinge residues; other site
590409009991	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
590409009992	N-acetyl-D-glucosamine binding site [chemical binding]; other site
590409009993	catalytic residue [active]
590409009994	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
590409009995	nucleoside/Zn binding site; other site
590409009996	dimer interface [polypeptide binding]; other site
590409009997	catalytic motif [active]
590409009998	N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441
590409009999	N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007
590409010000	putative active site [active]
590409010001	type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375
590409010002	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296
590409010003	putative active site [active]
590409010004	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
590409010005	ATP-binding cassette domain of bacteriocin exporters, subfamily C; Region: ABCC_bacteriocin_exporters; cd03245
590409010006	Walker A/P-loop; other site
590409010007	ATP binding site [chemical binding]; other site
590409010008	Q-loop/lid; other site
590409010009	ABC transporter signature motif; other site
590409010010	Walker B; other site
590409010011	D-loop; other site
590409010012	H-loop/switch region; other site
590409010013	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
590409010014	HlyD family secretion protein; Region: HlyD_3; pfam13437
590409010015	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
590409010016	PAS domain; Region: PAS_9; pfam13426
590409010017	putative active site [active]
590409010018	heme pocket [chemical binding]; other site
590409010019	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
590409010020	GAF domain; Region: GAF; pfam01590
590409010021	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
590409010022	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
590409010023	metal binding site [ion binding]; metal-binding site
590409010024	active site
590409010025	I-site; other site
590409010026	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
590409010027	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
590409010028	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
590409010029	Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003
590409010030	active site
590409010031	hydrophilic channel; other site
590409010032	dimerization interface [polypeptide binding]; other site
590409010033	catalytic residues [active]
590409010034	active site lid [active]
590409010035	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
590409010036	Recombination protein O N terminal; Region: RecO_N; pfam11967
590409010037	Recombination protein O C terminal; Region: RecO_C; pfam02565
590409010038	GTPase Era; Reviewed; Region: era; PRK00089
590409010039	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
590409010040	G1 box; other site
590409010041	GTP/Mg2+ binding site [chemical binding]; other site
590409010042	Switch I region; other site
590409010043	G2 box; other site
590409010044	Switch II region; other site
590409010045	G3 box; other site
590409010046	G4 box; other site
590409010047	G5 box; other site
590409010048	KH domain; Region: KH_2; pfam07650
590409010049	ribonuclease III; Reviewed; Region: rnc; PRK00102
590409010050	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
590409010051	dimerization interface [polypeptide binding]; other site
590409010052	active site
590409010053	metal binding site [ion binding]; metal-binding site
590409010054	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
590409010055	dsRNA binding site [nucleotide binding]; other site
590409010056	signal peptidase I; Provisional; Region: PRK10861
590409010057	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
590409010058	Catalytic site [active]
590409010059	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
590409010060	GTP-binding protein LepA; Provisional; Region: PRK05433
590409010061	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
590409010062	G1 box; other site
590409010063	putative GEF interaction site [polypeptide binding]; other site
590409010064	GTP/Mg2+ binding site [chemical binding]; other site
590409010065	Switch I region; other site
590409010066	G2 box; other site
590409010067	G3 box; other site
590409010068	Switch II region; other site
590409010069	G4 box; other site
590409010070	G5 box; other site
590409010071	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
590409010072	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
590409010073	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
590409010074	SoxR reducing system protein RseC; Provisional; Region: PRK10862
590409010075	anti-sigma E factor; Provisional; Region: rseB; PRK09455
590409010076	Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026
590409010077	anti-RNA polymerase sigma factor SigE; Provisional; Region: PRK10863
590409010078	Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872
590409010079	Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873
590409010080	RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939
590409010081	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
590409010082	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
590409010083	DNA binding residues [nucleotide binding]
590409010084	L-aspartate oxidase; Provisional; Region: PRK09077
590409010085	L-aspartate oxidase; Provisional; Region: PRK06175
590409010086	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
590409010087	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
590409010088	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
590409010089	S-adenosylmethionine binding site [chemical binding]; other site
590409010090	HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266
590409010091	ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192
590409010092	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
590409010093	ATP binding site [chemical binding]; other site
590409010094	Mg++ binding site [ion binding]; other site
590409010095	motif III; other site
590409010096	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
590409010097	nucleotide binding region [chemical binding]; other site
590409010098	ATP-binding site [chemical binding]; other site
590409010099	autonomous glycyl radical cofactor GrcA; Provisional; Region: PRK11127
590409010100	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
590409010101	ligand binding site [chemical binding]; other site
590409010102	active site
590409010103	UGI interface [polypeptide binding]; other site
590409010104	catalytic site [active]
590409010105	O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873
590409010106	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
590409010107	homodimer interface [polypeptide binding]; other site
590409010108	substrate-cofactor binding pocket; other site
590409010109	pyridoxal 5'-phosphate binding site [chemical binding]; other site
590409010110	catalytic residue [active]
590409010111	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
590409010112	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
590409010113	active site
590409010114	HIGH motif; other site
590409010115	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
590409010116	active site
590409010117	KMSKS motif; other site
590409010118	DoxX; Region: DoxX; pfam07681
590409010119	ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118
590409010120	ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296
590409010121	Walker A/P-loop; other site
590409010122	ATP binding site [chemical binding]; other site
590409010123	Q-loop/lid; other site
590409010124	ABC transporter signature motif; other site
590409010125	Walker B; other site
590409010126	D-loop; other site
590409010127	H-loop/switch region; other site
590409010128	TOBE-like domain; Region: TOBE_3; pfam12857
590409010129	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
590409010130	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
590409010131	dimer interface [polypeptide binding]; other site
590409010132	conserved gate region; other site
590409010133	putative PBP binding loops; other site
590409010134	ABC-ATPase subunit interface; other site
590409010135	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
590409010136	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
590409010137	dimer interface [polypeptide binding]; other site
590409010138	conserved gate region; other site
590409010139	putative PBP binding loops; other site
590409010140	ABC-ATPase subunit interface; other site
590409010141	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
590409010142	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
590409010143	substrate binding pocket [chemical binding]; other site
590409010144	membrane-bound complex binding site; other site
590409010145	hinge residues; other site
590409010146	carbohydrate diacid transcriptional activator CdaR; Provisional; Region: PRK11477
590409010147	Putative sugar diacid recognition; Region: Diacid_rec; pfam05651
590409010148	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
590409010149	serine endoprotease; Provisional; Region: PRK10942
590409010150	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
590409010151	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
590409010152	protein binding site [polypeptide binding]; other site
590409010153	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
590409010154	deoxyguanosinetriphosphate triphosphohydrolase; Provisional; Region: dgt; PRK04926
590409010155	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
590409010156	Zn2+ binding site [ion binding]; other site
590409010157	Mg2+ binding site [ion binding]; other site
590409010158	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
590409010159	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584
590409010160	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704
590409010161	vitamin B12-transporter protein BtuF; Provisional; Region: PRK03379
590409010162	Cobalamin binding protein BtuF.  These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species.  They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144
590409010163	cobalamin binding residues [chemical binding]; other site
590409010164	putative BtuC binding residues; other site
590409010165	dimer interface [polypeptide binding]; other site
590409010166	iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623
590409010167	ClC chloride channel EriC.  This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031
590409010168	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
590409010169	Cl- selectivity filter; other site
590409010170	Cl- binding residues [ion binding]; other site
590409010171	pore gating glutamate residue; other site
590409010172	dimer interface [polypeptide binding]; other site
590409010173	H+/Cl- coupling transport residue; other site
590409010174	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
590409010175	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
590409010176	inhibitor-cofactor binding pocket; inhibition site
590409010177	pyridoxal 5'-phosphate binding site [chemical binding]; other site
590409010178	catalytic residue [active]
590409010179	bifunctional glycosyl transferase/transpeptidase; Reviewed; Region: mrcB; PRK09506
590409010180	Transglycosylase; Region: Transgly; pfam00912
590409010181	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
590409010182	ATP-dependent RNA helicase HrpB; Provisional; Region: PRK11664
590409010183	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
590409010184	ATP binding site [chemical binding]; other site
590409010185	putative Mg++ binding site [ion binding]; other site
590409010186	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
590409010187	nucleotide binding region [chemical binding]; other site
590409010188	ATP-binding site [chemical binding]; other site
590409010189	Helicase associated domain (HA2) Add an annotation; Region: HA2; smart00847
590409010190	ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482
590409010191	2'-5' RNA ligase; Provisional; Region: PRK15124
590409010192	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
590409010193	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
590409010194	putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347
590409010195	RNA polymerase-binding transcription factor; Provisional; Region: dksA; PRK10778
590409010196	Glutamyl- and glutaminyl-tRNA synthetases [Translation, ribosomal structure and biogenesis]; Region: GlnS; COG0008
590409010197	glutamyl-queuosine tRNA(Asp) synthetase; Region: queuosine_YadB; TIGR03838
590409010198	active site
590409010199	HIGH motif; other site
590409010200	nucleotide binding site [chemical binding]; other site
590409010201	KMSKS motif; other site
590409010202	poly(A) polymerase I; Provisional; Region: pcnB; PRK11623
590409010203	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
590409010204	active site
590409010205	NTP binding site [chemical binding]; other site
590409010206	metal binding triad [ion binding]; metal-binding site
590409010207	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
590409010208	Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626
590409010209	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
590409010210	catalytic center binding site [active]
590409010211	ATP binding site [chemical binding]; other site
590409010212	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
590409010213	oligomerization interface [polypeptide binding]; other site
590409010214	active site
590409010215	metal binding site [ion binding]; metal-binding site
590409010216	Pantoate-beta-alanine ligase; Region: PanC; cd00560
590409010217	pantoate--beta-alanine ligase; Region: panC; TIGR00018
590409010218	active site
590409010219	ATP-binding site [chemical binding]; other site
590409010220	pantoate-binding site; other site
590409010221	HXXH motif; other site
590409010222	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
590409010223	tetramerization interface [polypeptide binding]; other site
590409010224	active site
590409010225	inner membrane transport permease; Provisional; Region: PRK15066
590409010226	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
590409010227	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
590409010228	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
590409010229	Walker A/P-loop; other site
590409010230	ATP binding site [chemical binding]; other site
590409010231	Q-loop/lid; other site
590409010232	ABC transporter signature motif; other site
590409010233	Walker B; other site
590409010234	D-loop; other site
590409010235	H-loop/switch region; other site
590409010236	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883
590409010237	active site clefts [active]
590409010238	zinc binding site [ion binding]; other site
590409010239	dimer interface [polypeptide binding]; other site
590409010240	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
590409010241	active site
590409010242	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
590409010243	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
590409010244	Coenzyme A binding pocket [chemical binding]; other site
590409010245	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
590409010246	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
590409010247	Walker A/P-loop; other site
590409010248	ATP binding site [chemical binding]; other site
590409010249	Q-loop/lid; other site
590409010250	ABC transporter signature motif; other site
590409010251	Walker B; other site
590409010252	D-loop; other site
590409010253	H-loop/switch region; other site
590409010254	TOBE domain; Region: TOBE_2; pfam08402
590409010255	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
590409010256	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
590409010257	dimer interface [polypeptide binding]; other site
590409010258	conserved gate region; other site
590409010259	putative PBP binding loops; other site
590409010260	ABC-ATPase subunit interface; other site
590409010261	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
590409010262	Bacterial chaperone lipoprotein (PulS_OutS); Region: PulS_OutS; cl09898
590409010263	spermidine synthase; Provisional; Region: PRK00811
590409010264	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
590409010265	S-adenosylmethionine binding site [chemical binding]; other site
590409010266	S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462
590409010267	DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406
590409010268	DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131
590409010269	active site
590409010270	catalytic site [active]
590409010271	substrate binding site [chemical binding]; other site
590409010272	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
590409010273	RNA/DNA hybrid binding site [nucleotide binding]; other site
590409010274	active site
590409010275	Methyltransferase domain; Region: Methyltransf_11; pfam08241
590409010276	hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413
590409010277	membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783
590409010278	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
590409010279	N-acetyl-D-glucosamine binding site [chemical binding]; other site
590409010280	catalytic residue [active]
590409010281	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
590409010282	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
590409010283	hypothetical protein; Provisional; Region: PRK05421
590409010284	putative catalytic site [active]
590409010285	putative metal binding site [ion binding]; other site
590409010286	putative catalytic site [active]
590409010287	putative phosphate binding site [ion binding]; other site
590409010288	putative phosphate binding site [ion binding]; other site
590409010289	putative metal binding site [ion binding]; other site
590409010290	protein disaggregation chaperone; Provisional; Region: PRK10865
590409010291	Clp amino terminal domain; Region: Clp_N; pfam02861
590409010292	Clp amino terminal domain; Region: Clp_N; pfam02861
590409010293	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
590409010294	Walker A motif; other site
590409010295	ATP binding site [chemical binding]; other site
590409010296	Walker B motif; other site
590409010297	arginine finger; other site
590409010298	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
590409010299	Walker A motif; other site
590409010300	ATP binding site [chemical binding]; other site
590409010301	Walker B motif; other site
590409010302	arginine finger; other site
590409010303	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
590409010304	hypothetical protein; Provisional; Region: PRK10723
590409010305	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
590409010306	23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180
590409010307	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
590409010308	RNA binding surface [nucleotide binding]; other site
590409010309	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
590409010310	active site
590409010311	outer membrane biogenesis protein BamD; Provisional; Region: PRK10866
590409010312	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
590409010313	30S subunit binding site; other site
590409010314	bifunctional chorismate mutase/prephenate dehydratase; Provisional; Region: pheA; PRK10622
590409010315	chorismate mutase domain of proteobacterial P-protein, clade 1; Region: CM_P_1; TIGR01797
590409010316	Prephenate dehydratase; Region: PDT; pfam00800
590409010317	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
590409010318	putative L-Phe binding site [chemical binding]; other site
590409010319	bifunctional chorismate mutase/prephenate dehydrogenase; Provisional; Region: tyrA; PRK11199
590409010320	Chorismate mutase type II; Region: CM_2; cl00693
590409010321	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
590409010322	prephenate dehydrogenase; Validated; Region: PRK08507
590409010323	phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755
590409010324	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
590409010325	lipoprotein; Provisional; Region: PRK11443
590409010326	Protein of unknown function (DUF2799); Region: DUF2799; pfam10973
590409010327	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
590409010328	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
590409010329	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
590409010330	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
590409010331	RimM N-terminal domain; Region: RimM; pfam01782
590409010332	PRC-barrel domain; Region: PRC; pfam05239
590409010333	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
590409010334	signal recognition particle protein; Provisional; Region: PRK10867
590409010335	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
590409010336	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
590409010337	P loop; other site
590409010338	GTP binding site [chemical binding]; other site
590409010339	Signal peptide binding domain; Region: SRP_SPB; pfam02978
590409010340	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4137
590409010341	S-ribosylhomocysteinase; Provisional; Region: PRK02260
590409010342	glutamate--cysteine ligase; Provisional; Region: PRK02107
590409010343	Predicted membrane protein [Function unknown]; Region: COG1238
590409010344	fructose-1-P/6-phosphogluconate phosphatase; Provisional; Region: PRK10725
590409010345	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
590409010346	motif II; other site
590409010347	carbon storage regulator; Provisional; Region: PRK01712
590409010348	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
590409010349	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
590409010350	motif 1; other site
590409010351	active site
590409010352	motif 2; other site
590409010353	motif 3; other site
590409010354	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
590409010355	DHHA1 domain; Region: DHHA1; pfam02272
590409010356	recombination regulator RecX; Reviewed; Region: recX; PRK00117
590409010357	recombinase A; Provisional; Region: recA; PRK09354
590409010358	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
590409010359	hexamer interface [polypeptide binding]; other site
590409010360	Walker A motif; other site
590409010361	ATP binding site [chemical binding]; other site
590409010362	Walker B motif; other site
590409010363	hypothetical protein; Validated; Region: PRK03661
590409010364	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817
590409010365	putative hydrophobic ligand binding site [chemical binding]; other site
590409010366	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
590409010367	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
590409010368	acetoin reductase; Validated; Region: PRK08643
590409010369	meso-2,3-butanediol dehydrogenase-like, classical (c) SDRs; Region: meso-BDH-like_SDR_c; cd05366
590409010370	NAD binding site [chemical binding]; other site
590409010371	homotetramer interface [polypeptide binding]; other site
590409010372	homodimer interface [polypeptide binding]; other site
590409010373	active site
590409010374	substrate binding site [chemical binding]; other site
590409010375	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
590409010376	Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154
590409010377	tetramer interface [polypeptide binding]; other site
590409010378	heme binding pocket [chemical binding]; other site
590409010379	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
590409010380	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
590409010381	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
590409010382	Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309
590409010383	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
590409010384	putative ligand binding site [chemical binding]; other site
590409010385	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
590409010386	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
590409010387	Walker A/P-loop; other site
590409010388	ATP binding site [chemical binding]; other site
590409010389	Q-loop/lid; other site
590409010390	ABC transporter signature motif; other site
590409010391	Walker B; other site
590409010392	D-loop; other site
590409010393	H-loop/switch region; other site
590409010394	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
590409010395	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
590409010396	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
590409010397	TM-ABC transporter signature motif; other site
590409010398	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
590409010399	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
590409010400	TM-ABC transporter signature motif; other site
590409010401	Phophatidylserine decarboxylase; Region: PSDC; pfam12588
590409010402	Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; pfam02666
590409010403	Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121
590409010404	putative catalytic cysteine [active]
590409010405	transcriptional regulator EutR; Provisional; Region: PRK10130
590409010406	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
590409010407	putative GTP-binding protein YjiA; Provisional; Region: PRK11537
590409010408	The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112
590409010409	P-loop, Walker A motif; other site
590409010410	Base recognition motif; other site
590409010411	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
590409010412	Uncharacterized small protein [Function unknown]; Region: COG2879
590409010413	carbon starvation protein A; Provisional; Region: PRK15015
590409010414	Carbon starvation protein CstA; Region: CstA; pfam02554
590409010415	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
590409010416	putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697
590409010417	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
590409010418	active site
590409010419	phosphorylation site [posttranslational modification]
590409010420	intermolecular recognition site; other site
590409010421	dimerization interface [polypeptide binding]; other site
590409010422	LytTr DNA-binding domain; Region: LytTR; pfam04397
590409010423	Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275
590409010424	5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694
590409010425	GAF domain; Region: GAF; pfam01590
590409010426	Histidine kinase; Region: His_kinase; pfam06580
590409010427	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
590409010428	ATP binding site [chemical binding]; other site
590409010429	Mg2+ binding site [ion binding]; other site
590409010430	G-X-G motif; other site
590409010431	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
590409010432	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
590409010433	DNA-binding site [nucleotide binding]; DNA binding site
590409010434	UTRA domain; Region: UTRA; pfam07702
590409010435	Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624
590409010436	Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659
590409010437	metal binding site [ion binding]; metal-binding site
590409010438	dimer interface [polypeptide binding]; other site
590409010439	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
590409010440	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503
590409010441	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
590409010442	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
590409010443	dimer interface [polypeptide binding]; other site
590409010444	conserved gate region; other site
590409010445	putative PBP binding loops; other site
590409010446	ABC-ATPase subunit interface; other site
590409010447	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
590409010448	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
590409010449	dimer interface [polypeptide binding]; other site
590409010450	conserved gate region; other site
590409010451	putative PBP binding loops; other site
590409010452	ABC-ATPase subunit interface; other site
590409010453	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
590409010454	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
590409010455	Walker A/P-loop; other site
590409010456	ATP binding site [chemical binding]; other site
590409010457	Q-loop/lid; other site
590409010458	ABC transporter signature motif; other site
590409010459	Walker B; other site
590409010460	D-loop; other site
590409010461	H-loop/switch region; other site
590409010462	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
590409010463	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
590409010464	Walker A/P-loop; other site
590409010465	ATP binding site [chemical binding]; other site
590409010466	Q-loop/lid; other site
590409010467	ABC transporter signature motif; other site
590409010468	Walker B; other site
590409010469	D-loop; other site
590409010470	H-loop/switch region; other site
590409010471	Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624
590409010472	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
590409010473	metal binding site [ion binding]; metal-binding site
590409010474	YCII-related domain; Region: YCII; cl00999
590409010475	Acyl carrier protein phosphodiesterase [Lipid metabolism]; Region: AcpD; COG1182
590409010476	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
590409010477	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
590409010478	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
590409010479	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138
590409010480	conserved cys residue [active]
590409010481	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
590409010482	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
590409010483	Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236
590409010484	D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945
590409010485	D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813
590409010486	acyl-activating enzyme (AAE) consensus motif; other site
590409010487	AMP binding site [chemical binding]; other site
590409010488	MBOAT, membrane-bound O-acyltransferase family; Region: MBOAT; cl00738
590409010489	D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092
590409010490	GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472
590409010491	short chain dehydrogenase; Provisional; Region: PRK07478
590409010492	classical (c) SDRs; Region: SDR_c; cd05233
590409010493	NAD(P) binding site [chemical binding]; other site
590409010494	active site
590409010495	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
590409010496	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
590409010497	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
590409010498	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
590409010499	DNA binding site [nucleotide binding]
590409010500	active site
590409010501	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
590409010502	Major Facilitator Superfamily; Region: MFS_1; pfam07690
590409010503	putative substrate translocation pore; other site
590409010504	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
590409010505	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153
590409010506	CRISPR-associated protein Cas10/Csm1, subtype III-A/MTUBE; Region: cas_TM1811_Csm1; TIGR02578
590409010507	CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cd09680
590409010508	CRISPR/Cas system-associated protein Csm2; Region: Csm2_III-A; cl00622
590409010509	CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl17214
590409010510	CRISPR/Cas system-associated RAMP superfamily protein Csm5; Region: Csm5_III-A; cl17437
590409010511	CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cl11443
590409010512	CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cl11443
590409010513	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725
590409010514	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
590409010515	non-specific DNA binding site [nucleotide binding]; other site
590409010516	salt bridge; other site
590409010517	sequence-specific DNA binding site [nucleotide binding]; other site
590409010518	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
590409010519	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
590409010520	putative catalytic cysteine [active]
590409010521	gamma-glutamyl kinase; Provisional; Region: PRK05429
590409010522	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
590409010523	nucleotide binding site [chemical binding]; other site
590409010524	homotetrameric interface [polypeptide binding]; other site
590409010525	putative phosphate binding site [ion binding]; other site
590409010526	putative allosteric binding site; other site
590409010527	PUA domain; Region: PUA; pfam01472
590409010528	DNA-binding transcriptional regulator Crl; Provisional; Region: PRK10984
590409010529	fermentation/respiration switch protein; Reviewed; Region: frsA; PRK05077
590409010530	Periplasmic glucan biosynthesis protein, MdoG; Region: MdoG; cl15433
590409010531	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
590409010532	active site
590409010533	Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893
590409010534	M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890
590409010535	metal binding site [ion binding]; metal-binding site
590409010536	dimer interface [polypeptide binding]; other site
590409010537	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
590409010538	active site
590409010539	DNA polymerase IV; Validated; Region: PRK02406
590409010540	DNA binding site [nucleotide binding]
590409010541	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034
590409010542	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
590409010543	Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121
590409010544	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
590409010545	putative active site [active]
590409010546	putative dimer interface [polypeptide binding]; other site
590409010547	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
590409010548	active site
590409010549	dimer interface [polypeptide binding]; other site
590409010550	acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463
590409010551	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
590409010552	active site
590409010553	Domain of unknown function (DUF1974); Region: DUF1974; pfam09317
590409010554	methylthioribose kinase; Reviewed; Region: mtnK; PRK09550
590409010555	S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512
590409010556	methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720
590409010557	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791
590409010558	Cupin domain; Region: Cupin_2; cl17218
590409010559	2,3-diketo-5-methylthio-1-phosphopentane phosphatase; Region: enolase-ppase; TIGR01691
590409010560	methylthioribulose-1-phosphate dehydratase; Provisional; Region: PRK09220
590409010561	intersubunit interface [polypeptide binding]; other site
590409010562	active site
590409010563	Zn2+ binding site [ion binding]; other site
590409010564	methionine aminotransferase; Validated; Region: PRK09082
590409010565	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
590409010566	pyridoxal 5'-phosphate binding site [chemical binding]; other site
590409010567	homodimer interface [polypeptide binding]; other site
590409010568	catalytic residue [active]
590409010569	C-N hydrolase family amidase; Provisional; Region: PRK10438
590409010570	Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575
590409010571	putative active site [active]
590409010572	catalytic triad [active]
590409010573	dimer interface [polypeptide binding]; other site
590409010574	multimer interface [polypeptide binding]; other site
590409010575	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
590409010576	active site
590409010577	catalytic site [active]
590409010578	allantoate amidohydrolase; Reviewed; Region: PRK09290
590409010579	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
590409010580	active site
590409010581	metal binding site [ion binding]; metal-binding site
590409010582	dimer interface [polypeptide binding]; other site
590409010583	Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075
590409010584	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
590409010585	catalytic residue [active]
590409010586	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
590409010587	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
590409010588	Walker A/P-loop; other site
590409010589	ATP binding site [chemical binding]; other site
590409010590	Q-loop/lid; other site
590409010591	ABC transporter signature motif; other site
590409010592	Walker B; other site
590409010593	D-loop; other site
590409010594	H-loop/switch region; other site
590409010595	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
590409010596	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
590409010597	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
590409010598	ABC-ATPase subunit interface; other site
590409010599	putative PBP binding loops; other site
590409010600	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
590409010601	dimer interface [polypeptide binding]; other site
590409010602	conserved gate region; other site
590409010603	putative PBP binding loops; other site
590409010604	ABC-ATPase subunit interface; other site
590409010605	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
590409010606	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
590409010607	substrate binding pocket [chemical binding]; other site
590409010608	membrane-bound complex binding site; other site
590409010609	hinge residues; other site
590409010610	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
590409010611	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
590409010612	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
590409010613	putative active site [active]
590409010614	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
590409010615	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
590409010616	Protein of unknown function (DUF4089); Region: DUF4089; pfam13318
590409010617	amidase; Provisional; Region: PRK09201
590409010618	Amidase; Region: Amidase; cl11426
590409010619	Protein of unknown function (DUF3225); Region: DUF3225; pfam11533
590409010620	SnoaL-like domain; Region: SnoaL_3; pfam13474
590409010621	putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212
590409010622	Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977
590409010623	active site
590409010624	catalytic site [active]
590409010625	tetramer interface [polypeptide binding]; other site
590409010626	Hydantoin racemase [Amino acid transport and metabolism]; Region: COG4126
590409010627	Transcriptional regulators [Transcription]; Region: FadR; COG2186
590409010628	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
590409010629	DNA-binding site [nucleotide binding]; DNA binding site
590409010630	FCD domain; Region: FCD; pfam07729
590409010631	uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding domain; Region: SLC-NCS1sbd_u1; cd11555
590409010632	Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133
590409010633	Na binding site [ion binding]; other site
590409010634	putative substrate binding site [chemical binding]; other site
590409010635	allophanate hydrolase; Provisional; Region: PRK08186
590409010636	Amidase; Region: Amidase; pfam01425
590409010637	Transcriptional regulators [Transcription]; Region: GntR; COG1802
590409010638	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
590409010639	DNA-binding site [nucleotide binding]; DNA binding site
590409010640	FCD domain; Region: FCD; pfam07729
590409010641	glycine betaine transporter ATP-binding subunit; Provisional; Region: PRK10070
590409010642	ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294
590409010643	Walker A/P-loop; other site
590409010644	ATP binding site [chemical binding]; other site
590409010645	Q-loop/lid; other site
590409010646	ABC transporter signature motif; other site
590409010647	Walker B; other site
590409010648	D-loop; other site
590409010649	H-loop/switch region; other site
590409010650	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583
590409010651	glycine betaine transporter membrane protein; Provisional; Region: PRK10952
590409010652	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
590409010653	dimer interface [polypeptide binding]; other site
590409010654	conserved gate region; other site
590409010655	putative PBP binding loops; other site
590409010656	ABC-ATPase subunit interface; other site
590409010657	glycine betaine transporter periplasmic subunit; Provisional; Region: proX; PRK11119
590409010658	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
590409010659	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
590409010660	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
590409010661	Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296
590409010662	putative L-valine exporter; Provisional; Region: PRK10408
590409010663	transcriptional repressor MprA; Provisional; Region: PRK10870
590409010664	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
590409010665	multidrug efflux system protein EmrA; Provisional; Region: PRK15136
590409010666	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
590409010667	HlyD family secretion protein; Region: HlyD_3; pfam13437
590409010668	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
590409010669	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
590409010670	putative substrate translocation pore; other site
590409010671	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
590409010672	putative methyltransferase; Provisional; Region: PRK10864
590409010673	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
590409010674	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
590409010675	thioredoxin 2; Provisional; Region: PRK10996
590409010676	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
590409010677	catalytic residues [active]
590409010678	Uncharacterized conserved protein [Function unknown]; Region: COG3148
590409010679	Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042
590409010680	CoA binding domain; Region: CoA_binding_2; pfam13380
590409010681	Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607
590409010682	ATP-grasp domain; Region: ATP-grasp_5; pfam13549
590409010683	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
590409010684	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
590409010685	phosphatidylserine synthase; Provisional; Region: pssA; PRK09428
590409010686	Catalytic domain, repeat 1, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_1; cd09134
590409010687	domain interface [polypeptide binding]; other site
590409010688	putative active site [active]
590409010689	catalytic site [active]
590409010690	Catalytic domain, repeat 2, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_2; cd09136
590409010691	domain interface [polypeptide binding]; other site
590409010692	putative active site [active]
590409010693	catalytic site [active]
590409010694	alpha-ketoglutarate transporter; Provisional; Region: PRK10406
590409010695	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
590409010696	putative substrate translocation pore; other site
590409010697	D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942
590409010698	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
590409010699	active site
590409010700	motif I; other site
590409010701	motif II; other site
590409010702	DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153
590409010703	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
590409010704	Walker A/P-loop; other site
590409010705	ATP binding site [chemical binding]; other site
590409010706	Q-loop/lid; other site
590409010707	ABC transporter signature motif; other site
590409010708	Walker B; other site
590409010709	D-loop; other site
590409010710	H-loop/switch region; other site
590409010711	This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930
590409010712	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
590409010713	dimer interface [polypeptide binding]; other site
590409010714	conserved gate region; other site
590409010715	ABC-ATPase subunit interface; other site
590409010716	DL-methionine transporter substrate-binding subunit; Provisional; Region: metQ; PRK11063
590409010717	lipoprotein, YaeC family; Region: TIGR00363
590409010718	outer membrane lipoprotein; Reviewed; Region: rcsF; PRK10781
590409010719	Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281
590409010720	homodimer interaction site [polypeptide binding]; other site
590409010721	cofactor binding site; other site
590409010722	prolyl-tRNA synthetase; Provisional; Region: PRK09194
590409010723	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
590409010724	dimer interface [polypeptide binding]; other site
590409010725	motif 1; other site
590409010726	active site
590409010727	motif 2; other site
590409010728	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
590409010729	putative deacylase active site [active]
590409010730	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
590409010731	active site
590409010732	motif 3; other site
590409010733	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
590409010734	anticodon binding site; other site
590409010735	RNA polymerase sigma factor RpoS; Validated; Region: PRK05657
590409010736	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
590409010737	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
590409010738	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
590409010739	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
590409010740	DNA binding residues [nucleotide binding]
590409010741	lipoprotein NlpD; Provisional; Region: nlpD; PRK10871
590409010742	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
590409010743	Peptidase family M23; Region: Peptidase_M23; pfam01551
590409010744	protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312
590409010745	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
590409010746	S-adenosylmethionine binding site [chemical binding]; other site
590409010747	tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984
590409010748	Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575
590409010749	Permutation of conserved domain; other site
590409010750	active site
590409010751	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
590409010752	homotrimer interaction site [polypeptide binding]; other site
590409010753	zinc binding site [ion binding]; other site
590409010754	CDP-binding sites; other site
590409010755	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
590409010756	substrate binding site; other site
590409010757	dimer interface; other site
590409010758	cell division protein FtsB; Reviewed; Region: ftsB; PRK00888
590409010759	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
590409010760	hypothetical protein; Provisional; Region: PRK10726
590409010761	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
590409010762	ligand-binding site [chemical binding]; other site
590409010763	sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124
590409010764	CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166
590409010765	CysD dimerization site [polypeptide binding]; other site
590409010766	G1 box; other site
590409010767	putative GEF interaction site [polypeptide binding]; other site
590409010768	GTP/Mg2+ binding site [chemical binding]; other site
590409010769	Switch I region; other site
590409010770	G2 box; other site
590409010771	G3 box; other site
590409010772	Switch II region; other site
590409010773	G4 box; other site
590409010774	G5 box; other site
590409010775	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
590409010776	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
590409010777	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
590409010778	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
590409010779	Active Sites [active]
590409010780	siroheme synthase; Provisional; Region: cysG; PRK10637
590409010781	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
590409010782	Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414
590409010783	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
590409010784	active site
590409010785	SAM binding site [chemical binding]; other site
590409010786	homodimer interface [polypeptide binding]; other site
590409010787	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
590409010788	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
590409010789	Active Sites [active]
590409010790	sulfite reductase subunit beta; Provisional; Region: PRK13504
590409010791	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
590409010792	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
590409010793	sulfite reductase subunit alpha; Provisional; Region: cysJ; PRK10953
590409010794	Flavodoxin; Region: Flavodoxin_1; pfam00258
590409010795	Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199
590409010796	FAD binding pocket [chemical binding]; other site
590409010797	FAD binding motif [chemical binding]; other site
590409010798	catalytic residues [active]
590409010799	NAD binding pocket [chemical binding]; other site
590409010800	phosphate binding motif [ion binding]; other site
590409010801	beta-alpha-beta structure motif; other site
590409010802	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
590409010803	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
590409010804	Probable polygalacturonase At3g15720; Region: PLN03003; cl14103
590409010805	Glycosyl hydrolases family 28; Region: Glyco_hydro_28; pfam00295
590409010806	Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1),  6-pyrovoyl...; Region: TFold; cl00263
590409010807	active site
590409010808	Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602
590409010809	putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322
590409010810	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
590409010811	Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225
590409010812	Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211
590409010813	melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392
590409010814	enolase; Provisional; Region: eno; PRK00077
590409010815	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
590409010816	dimer interface [polypeptide binding]; other site
590409010817	metal binding site [ion binding]; metal-binding site
590409010818	substrate binding pocket [chemical binding]; other site
590409010819	CTP synthetase; Validated; Region: pyrG; PRK05380
590409010820	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
590409010821	Catalytic site [active]
590409010822	active site
590409010823	UTP binding site [chemical binding]; other site
590409010824	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
590409010825	active site
590409010826	putative oxyanion hole; other site
590409010827	catalytic triad [active]
590409010828	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562
590409010829	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
590409010830	homodimer interface [polypeptide binding]; other site
590409010831	metal binding site [ion binding]; metal-binding site
590409010832	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
590409010833	homodimer interface [polypeptide binding]; other site
590409010834	active site
590409010835	putative chemical substrate binding site [chemical binding]; other site
590409010836	metal binding site [ion binding]; metal-binding site
590409010837	(p)ppGpp synthetase I/GTP pyrophosphokinase; Provisional; Region: relA; PRK10872
590409010838	HD domain; Region: HD_4; pfam13328
590409010839	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
590409010840	synthetase active site [active]
590409010841	NTP binding site [chemical binding]; other site
590409010842	metal binding site [ion binding]; metal-binding site
590409010843	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
590409010844	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
590409010845	23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168
590409010846	TRAM domain; Region: TRAM; pfam01938
590409010847	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
590409010848	S-adenosylmethionine binding site [chemical binding]; other site
590409010849	hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107
590409010850	Uncharacterized signal transduction histidine kinase domain (DUF2222); Region: DUF2222; pfam09984
590409010851	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
590409010852	dimerization interface [polypeptide binding]; other site
590409010853	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
590409010854	dimer interface [polypeptide binding]; other site
590409010855	phosphorylation site [posttranslational modification]
590409010856	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
590409010857	ATP binding site [chemical binding]; other site
590409010858	Mg2+ binding site [ion binding]; other site
590409010859	G-X-G motif; other site
590409010860	Uncharacterized domain of BarA-like signal transduction histidine kinases [Signal transduction mechanisms]; Region: COG4999
590409010861	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
590409010862	active site
590409010863	phosphorylation site [posttranslational modification]
590409010864	intermolecular recognition site; other site
590409010865	dimerization interface [polypeptide binding]; other site
590409010866	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
590409010867	putative binding surface; other site
590409010868	active site
590409010869	Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929
590409010870	tartronate semialdehyde reductase; Provisional; Region: garR; PRK11559
590409010871	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
590409010872	alpha-dehydro-beta-deoxy-D-glucarate aldolase; Provisional; Region: PRK10558
590409010873	glucarate dehydratase; Region: glucar-dehydr; TIGR03247
590409010874	D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323
590409010875	active site
590409010876	tetramer interface [polypeptide binding]; other site
590409010877	glucarate dehydratase; Region: glucar-dehydr; TIGR03247
590409010878	D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323
590409010879	active site
590409010880	tetramer interface [polypeptide binding]; other site
590409010881	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
590409010882	D-galactonate transporter; Region: 2A0114; TIGR00893
590409010883	putative substrate translocation pore; other site
590409010884	galactarate dehydratase; Region: galactar-dH20; TIGR03248
590409010885	Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613
590409010886	D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295
590409010887	PAS fold; Region: PAS_3; pfam08447
590409010888	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
590409010889	putative active site [active]
590409010890	heme pocket [chemical binding]; other site
590409010891	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
590409010892	dimerization interface [polypeptide binding]; other site
590409010893	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
590409010894	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
590409010895	dimer interface [polypeptide binding]; other site
590409010896	putative CheW interface [polypeptide binding]; other site
590409010897	Protein of unknown function (DUF3251); Region: DUF3251; cl08186
590409010898	Protein of unknown function (DUF3820); Region: DUF3820; pfam12843
590409010899	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
590409010900	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
590409010901	nucleotide binding pocket [chemical binding]; other site
590409010902	K-X-D-G motif; other site
590409010903	catalytic site [active]
590409010904	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
590409010905	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
590409010906	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
590409010907	Dimer interface [polypeptide binding]; other site
590409010908	bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316
590409010909	RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172
590409010910	putative ribose interaction site [chemical binding]; other site
590409010911	putative ADP binding site [chemical binding]; other site
590409010912	rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199
590409010913	active site
590409010914	nucleotide binding site [chemical binding]; other site
590409010915	HIGH motif; other site
590409010916	KMSKS motif; other site
590409010917	bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072
590409010918	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
590409010919	metal binding triad; other site
590409010920	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
590409010921	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
590409010922	metal binding triad; other site
590409010923	Uncharacterized conserved protein [Function unknown]; Region: COG3025
590409010924	Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756
590409010925	putative active site [active]
590409010926	putative metal binding residues [ion binding]; other site
590409010927	signature motif; other site
590409010928	putative triphosphate binding site [ion binding]; other site
590409010929	SH3 domain protein [Signal transduction mechanisms]; Region: COG3103
590409010930	Bacterial SH3 domain homologues; Region: SH3b; smart00287
590409010931	multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885
590409010932	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
590409010933	active site
590409010934	NTP binding site [chemical binding]; other site
590409010935	metal binding triad [ion binding]; metal-binding site
590409010936	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
590409010937	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
590409010938	Zn2+ binding site [ion binding]; other site
590409010939	Mg2+ binding site [ion binding]; other site
590409010940	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
590409010941	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
590409010942	homooctamer interface [polypeptide binding]; other site
590409010943	active site
590409010944	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
590409010945	ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144
590409010946	ligand binding site [chemical binding]; other site
590409010947	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
590409010948	dimerization interface [polypeptide binding]; other site
590409010949	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
590409010950	dimer interface [polypeptide binding]; other site
590409010951	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
590409010952	putative CheW interface [polypeptide binding]; other site
590409010953	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
590409010954	dimer interface [polypeptide binding]; other site
590409010955	substrate binding site [chemical binding]; other site
590409010956	metal binding sites [ion binding]; metal-binding site
590409010957	SnoaL-like domain; Region: SnoaL_2; pfam12680
590409010958	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
590409010959	dimer interface [polypeptide binding]; other site
590409010960	motif 1; other site
590409010961	active site
590409010962	motif 2; other site
590409010963	motif 3; other site
590409010964	Cupin domain; Region: Cupin_2; cl17218
590409010965	histidinol-phosphate aminotransferase; Region: hisC; TIGR01141
590409010966	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
590409010967	pyridoxal 5'-phosphate binding site [chemical binding]; other site
590409010968	homodimer interface [polypeptide binding]; other site
590409010969	catalytic residue [active]
590409010970	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
590409010971	putative active site pocket [active]
590409010972	dimerization interface [polypeptide binding]; other site
590409010973	putative catalytic residue [active]
590409010974	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911
590409010975	Family of unknown function (DUF490); Region: DUF490; pfam04357
590409010976	Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729
590409010977	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
590409010978	Surface antigen; Region: Bac_surface_Ag; pfam01103
590409010979	methionine sulfoxide reductase A; Provisional; Region: PRK00058
590409010980	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
590409010981	Domain of unknown function DUF21; Region: DUF21; pfam01595
590409010982	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
590409010983	Transporter associated domain; Region: CorC_HlyC; smart01091
590409010984	Protein of unknown function (DUF1107); Region: DUF1107; pfam06526
590409010985	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
590409010986	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
590409010987	active site
590409010988	bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420
590409010989	Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410
590409010990	active site
590409010991	metal binding site [ion binding]; metal-binding site
590409010992	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
590409010993	iron-sulfur cluster repair di-iron protein; Provisional; Region: PRK10992
590409010994	Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405
590409010995	Hemerythrin-like domain; Region: Hr-like; cd12108
590409010996	Fe binding site [ion binding]; other site
590409010997	Protein of unknown function (DUF2502); Region: DUF2502; pfam10697
590409010998	peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK11570
590409010999	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
590409011000	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
590409011001	Cell envelope opacity-associated protein A [Cell envelope biogenesis, outer membrane]; Region: OapA; COG3061
590409011002	Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225
590409011003	Protein of unknown function, DUF488; Region: DUF488; cl01246
590409011004	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
590409011005	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
590409011006	inhibitor site; inhibition site
590409011007	active site
590409011008	dimer interface [polypeptide binding]; other site
590409011009	catalytic residue [active]
590409011010	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
590409011011	transcriptional repressor RbsR; Provisional; Region: PRK10423
590409011012	domain linker motif; other site
590409011013	Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_7; cd06285
590409011014	putative dimerization interface [polypeptide binding]; other site
590409011015	putative ligand binding site [chemical binding]; other site
590409011016	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
590409011017	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
590409011018	dimerization interface [polypeptide binding]; other site
590409011019	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
590409011020	dimer interface [polypeptide binding]; other site
590409011021	putative CheW interface [polypeptide binding]; other site
590409011022	benzoate transport; Region: 2A0115; TIGR00895
590409011023	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
590409011024	putative substrate translocation pore; other site
590409011025	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
590409011026	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
590409011027	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
590409011028	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
590409011029	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
590409011030	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
590409011031	dimer interface [polypeptide binding]; other site
590409011032	ssDNA binding site [nucleotide binding]; other site
590409011033	tetramer (dimer of dimers) interface [polypeptide binding]; other site
590409011034	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
590409011035	esterase; Provisional; Region: PRK10566
590409011036	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
590409011037	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
590409011038	dimerization interface [polypeptide binding]; other site
590409011039	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
590409011040	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
590409011041	dimer interface [polypeptide binding]; other site
590409011042	putative CheW interface [polypeptide binding]; other site
590409011043	putative biofilm stress and motility protein A; Provisional; Region: PRK14864
590409011044	23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181
590409011045	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
590409011046	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
590409011047	exoribonuclease R; Provisional; Region: PRK11642
590409011048	Ribonuclease R winged-helix domain; Region: HTH_12; pfam08461
590409011049	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
590409011050	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
590409011051	RNB domain; Region: RNB; pfam00773
590409011052	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
590409011053	RNA binding site [nucleotide binding]; other site
590409011054	transcriptional repressor NsrR; Provisional; Region: PRK11014
590409011055	Rrf2 family protein; Region: rrf2_super; TIGR00738
590409011056	ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181
590409011057	dimer interface [polypeptide binding]; other site
590409011058	ligand binding site [chemical binding]; other site
590409011059	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
590409011060	dimerization interface [polypeptide binding]; other site
590409011061	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
590409011062	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
590409011063	dimer interface [polypeptide binding]; other site
590409011064	putative CheW interface [polypeptide binding]; other site
590409011065	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
590409011066	cytosine deaminase; Provisional; Region: PRK09230
590409011067	Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293
590409011068	active site
590409011069	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
590409011070	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
590409011071	putative active site [active]
590409011072	heme pocket [chemical binding]; other site
590409011073	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
590409011074	putative active site [active]
590409011075	heme pocket [chemical binding]; other site
590409011076	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
590409011077	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
590409011078	metal binding site [ion binding]; metal-binding site
590409011079	active site
590409011080	I-site; other site
590409011081	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
590409011082	Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805
590409011083	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
590409011084	Walker A motif; other site
590409011085	ATP binding site [chemical binding]; other site
590409011086	Walker B motif; other site
590409011087	Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824
590409011088	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
590409011089	catalytic residue [active]
590409011090	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
590409011091	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
590409011092	YGGT family; Region: YGGT; pfam02325
590409011093	YGGT family; Region: YGGT; pfam02325
590409011094	hypothetical protein; Validated; Region: PRK05090
590409011095	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
590409011096	active site
590409011097	dimerization interface [polypeptide binding]; other site
590409011098	HemN family oxidoreductase; Provisional; Region: PRK05660
590409011099	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
590409011100	FeS/SAM binding site; other site
590409011101	HemN C-terminal domain; Region: HemN_C; pfam06969
590409011102	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
590409011103	PAS domain; Region: PAS_9; pfam13426
590409011104	putative active site [active]
590409011105	heme pocket [chemical binding]; other site
590409011106	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
590409011107	PAS fold; Region: PAS_3; pfam08447
590409011108	putative active site [active]
590409011109	heme pocket [chemical binding]; other site
590409011110	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
590409011111	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
590409011112	metal binding site [ion binding]; metal-binding site
590409011113	active site
590409011114	I-site; other site
590409011115	entericidin A; Provisional; Region: PRK09810
590409011116	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
590409011117	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
590409011118	Coenzyme A binding pocket [chemical binding]; other site
590409011119	lysophospholipid transporter LplT; Provisional; Region: PRK11195
590409011120	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
590409011121	putative substrate translocation pore; other site
590409011122	bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase; Validated; Region: PRK08043
590409011123	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
590409011124	putative acyl-acceptor binding pocket; other site
590409011125	C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Region: AAS_C; cd05909
590409011126	acyl-activating enzyme (AAE) consensus motif; other site
590409011127	putative AMP binding site [chemical binding]; other site
590409011128	Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases [Posttranslational modification, protein turnover, chaperones]; Region: COG3555
590409011129	DNA-binding transcriptional regulator GalR; Provisional; Region: PRK10727
590409011130	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
590409011131	DNA binding site [nucleotide binding]
590409011132	domain linker motif; other site
590409011133	Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270
590409011134	dimerization interface (closed form) [polypeptide binding]; other site
590409011135	ligand binding site [chemical binding]; other site
590409011136	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
590409011137	Coenzyme A binding pocket [chemical binding]; other site
590409011138	DNA-binding transcriptional repressor UxuR; Provisional; Region: PRK10225
590409011139	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
590409011140	DNA-binding site [nucleotide binding]; DNA binding site
590409011141	FCD domain; Region: FCD; pfam07729
590409011142	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
590409011143	active site
590409011144	P-loop; other site
590409011145	phosphorylation site [posttranslational modification]
590409011146	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
590409011147	beta-galactosidase; Region: BGL; TIGR03356
590409011148	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
590409011149	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
590409011150	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
590409011151	methionine cluster; other site
590409011152	active site
590409011153	phosphorylation site [posttranslational modification]
590409011154	metal binding site [ion binding]; metal-binding site
590409011155	Transcriptional regulators [Transcription]; Region: PurR; COG1609
590409011156	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
590409011157	DNA binding site [nucleotide binding]
590409011158	domain linker motif; other site
590409011159	Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270
590409011160	dimerization interface (closed form) [polypeptide binding]; other site
590409011161	ligand binding site [chemical binding]; other site
590409011162	diaminopimelate decarboxylase; Provisional; Region: PRK11165
590409011163	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
590409011164	active site
590409011165	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
590409011166	substrate binding site [chemical binding]; other site
590409011167	catalytic residues [active]
590409011168	dimer interface [polypeptide binding]; other site
590409011169	DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013
590409011170	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
590409011171	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
590409011172	dimerization interface [polypeptide binding]; other site
590409011173	type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344
590409011174	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
590409011175	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
590409011176	Walker A/P-loop; other site
590409011177	ATP binding site [chemical binding]; other site
590409011178	Q-loop/lid; other site
590409011179	ABC transporter signature motif; other site
590409011180	Walker B; other site
590409011181	D-loop; other site
590409011182	H-loop/switch region; other site
590409011183	TOBE domain; Region: TOBE_2; pfam08402
590409011184	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
590409011185	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
590409011186	dimer interface [polypeptide binding]; other site
590409011187	conserved gate region; other site
590409011188	putative PBP binding loops; other site
590409011189	ABC-ATPase subunit interface; other site
590409011190	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
590409011191	dimer interface [polypeptide binding]; other site
590409011192	conserved gate region; other site
590409011193	ABC-ATPase subunit interface; other site
590409011194	Uncharacterized proteins of the AP superfamily [General function prediction only]; Region: COG1524
590409011195	phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335
590409011196	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
590409011197	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
590409011198	transcriptional regulator protein; Region: phnR; TIGR03337
590409011199	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
590409011200	DNA-binding site [nucleotide binding]; DNA binding site
590409011201	UTRA domain; Region: UTRA; pfam07702
590409011202	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
590409011203	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283
590409011204	putative NAD(P) binding site [chemical binding]; other site
590409011205	putative substrate binding site [chemical binding]; other site
590409011206	catalytic Zn binding site [ion binding]; other site
590409011207	structural Zn binding site [ion binding]; other site
590409011208	dimer interface [polypeptide binding]; other site
590409011209	ribonucleoside transporter; Reviewed; Region: nepI; PRK10213
590409011210	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
590409011211	putative substrate translocation pore; other site
590409011212	Uncharacterized conserved protein [Function unknown]; Region: COG4925
590409011213	Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073
590409011214	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
590409011215	Transcriptional regulator [Transcription]; Region: LysR; COG0583
590409011216	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
590409011217	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474
590409011218	putative effector binding pocket; other site
590409011219	putative dimerization interface [polypeptide binding]; other site
590409011220	tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815
590409011221	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
590409011222	FMN binding site [chemical binding]; other site
590409011223	active site
590409011224	catalytic residues [active]
590409011225	substrate binding site [chemical binding]; other site
590409011226	phage shock protein G; Reviewed; Region: pspG; PRK09459
590409011227	quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754
590409011228	Quinone oxidoreductase (QOR); Region: QOR2; cd05286
590409011229	NADP binding site [chemical binding]; other site
590409011230	dimer interface [polypeptide binding]; other site
590409011231	replicative DNA helicase; Provisional; Region: PRK08006
590409011232	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
590409011233	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
590409011234	Walker A motif; other site
590409011235	ATP binding site [chemical binding]; other site
590409011236	Walker B motif; other site
590409011237	DNA binding loops [nucleotide binding]
590409011238	alanine racemase; Reviewed; Region: alr; PRK00053
590409011239	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827
590409011240	active site
590409011241	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
590409011242	substrate binding site [chemical binding]; other site
590409011243	catalytic residues [active]
590409011244	dimer interface [polypeptide binding]; other site
590409011245	Protein of unknown function (DUF1471); Region: DUF1471; pfam07338
590409011246	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
590409011247	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
590409011248	substrate binding pocket [chemical binding]; other site
590409011249	membrane-bound complex binding site; other site
590409011250	hinge residues; other site
590409011251	aromatic amino acid transporter; Provisional; Region: PRK10238
590409011252	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
590409011253	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
590409011254	AsnC family; Region: AsnC_trans_reg; pfam01037
590409011255	Uncharacterized conserved protein [Function unknown]; Region: COG1284
590409011256	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
590409011257	aromatic amino acid aminotransferase; Provisional; Region: PRK09257
590409011258	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
590409011259	pyridoxal 5'-phosphate binding site [chemical binding]; other site
590409011260	homodimer interface [polypeptide binding]; other site
590409011261	catalytic residue [active]
590409011262	CRISPR/Cas system-associated RAMP superfamily protein Cas6f; Region: Cas6_I-F; cd09739
590409011263	CRISPR/Cas system-associated RAMP superfamily protein Csy3; Region: Csy3_I-F; cd09737
590409011264	CRISPR/Cas system-associated RAMP superfamily protein Csy2; Region: Csy2_I-F; cd09736
590409011265	CRISPR/Cas system-associated protein Csy1; Region: Csy1_I-F; cd09735
590409011266	CRISPR/Cas system-associated protein Cas3/Cas2; Region: Cas3_Cas2_I-F; cd09673
590409011267	CRISPR-associated helicase Cas3, subtype I-F/YPEST; Region: cas3_yersinia; TIGR02562
590409011268	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656
590409011269	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
590409011270	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
590409011271	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
590409011272	dimerization interface [polypeptide binding]; other site
590409011273	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
590409011274	dimer interface [polypeptide binding]; other site
590409011275	putative CheW interface [polypeptide binding]; other site
590409011276	Cache domain; Region: Cache_1; pfam02743
590409011277	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
590409011278	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
590409011279	metal binding site [ion binding]; metal-binding site
590409011280	active site
590409011281	I-site; other site
590409011282	Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894
590409011283	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
590409011284	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
590409011285	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
590409011286	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
590409011287	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
590409011288	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
590409011289	dimer interface [polypeptide binding]; other site
590409011290	ssDNA binding site [nucleotide binding]; other site
590409011291	tetramer (dimer of dimers) interface [polypeptide binding]; other site
590409011292	Uncharacterized protein conserved in bacteria (DUF2186); Region: DUF2186; pfam09952
590409011293	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
590409011294	CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250
590409011295	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
590409011296	NAD binding site [chemical binding]; other site
590409011297	active site
590409011298	Protein of unknown function (DUF4255); Region: DUF4255; pfam14065
590409011299	Phage tail sheath protein FI [General function prediction only]; Region: COG3497
590409011300	T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841
590409011301	T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841
590409011302	Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652
590409011303	Phage protein D [General function prediction only]; Region: COG3500
590409011304	Rhs element Vgr protein; Region: vgr_GE; TIGR01646
590409011305	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
590409011306	Uncharacterized conserved protein [Function unknown]; Region: COG4104
590409011307	Gene 25-like lysozyme; Region: GPW_gp25; pfam04965
590409011308	conserved hypothetical protein, phage tail-like region; Region: TIGR02243
590409011309	conserved hypothetical protein, phage tail-like region; Region: TIGR02243
590409011310	Transcriptional regulators [Transcription]; Region: PurR; COG1609
590409011311	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
590409011312	DNA binding site [nucleotide binding]
590409011313	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
590409011314	ligand binding site [chemical binding]; other site
590409011315	dimerization interface [polypeptide binding]; other site
590409011316	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
590409011317	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
590409011318	dimer interface [polypeptide binding]; other site
590409011319	conserved gate region; other site
590409011320	putative PBP binding loops; other site
590409011321	ABC-ATPase subunit interface; other site
590409011322	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
590409011323	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
590409011324	ABC-ATPase subunit interface; other site
590409011325	putative PBP binding loops; other site
590409011326	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
590409011327	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
590409011328	Walker A/P-loop; other site
590409011329	ATP binding site [chemical binding]; other site
590409011330	Q-loop/lid; other site
590409011331	ABC transporter signature motif; other site
590409011332	Walker B; other site
590409011333	D-loop; other site
590409011334	H-loop/switch region; other site
590409011335	TOBE domain; Region: TOBE_2; pfam08402
590409011336	Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225
590409011337	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
590409011338	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
590409011339	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
590409011340	Predicted N-acetylglucosamine kinase [Carbohydrate transport and metabolism]; Region: COG2971
590409011341	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
590409011342	dimer interface [polypeptide binding]; other site
590409011343	conserved gate region; other site
590409011344	putative PBP binding loops; other site
590409011345	ABC-ATPase subunit interface; other site
590409011346	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
590409011347	tungstate ABC transporter binding protein WtpA; Region: tungstate_WtpA; TIGR03730
590409011348	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
590409011349	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
590409011350	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
590409011351	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
590409011352	ABC-ATPase subunit  interface; other site
590409011353	dimer interface [polypeptide binding]; other site
590409011354	putative PBP binding regions; other site
590409011355	Metal binding protein PsaA.  These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137
590409011356	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
590409011357	metal binding site [ion binding]; metal-binding site
590409011358	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
590409011359	The single-domain 2,3-dihydroxybiphenyl 1,2-dioxygenases (BphC, EC 1.13.11.39) from Rhodococcus globerulus P6, BphC2-RGP6 and BphC3-RGP6,  and similar proteins; Region: BphC2-C3-RGP6_C_like; cd08348
590409011360	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
590409011361	putative active site [active]
590409011362	putative metal binding site [ion binding]; other site
590409011363	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
590409011364	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
590409011365	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
590409011366	4-hydroxythreonine-4-phosphate dehydrogenase 2; Provisional; Region: pdxA; PRK03371
590409011367	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
590409011368	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395
590409011369	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
590409011370	5-hydroxyvalerate dehydrogenase (HVD) catalyzes the oxidation of 5-hydroxyvalerate to 5-oxovalerate with NAD+ as cofactor; Region: HVD; cd08193
590409011371	putative active site [active]
590409011372	metal binding site [ion binding]; metal-binding site
590409011373	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
590409011374	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
590409011375	inhibitor site; inhibition site
590409011376	active site
590409011377	dimer interface [polypeptide binding]; other site
590409011378	catalytic residue [active]
590409011379	Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322
590409011380	Na binding site [ion binding]; other site
590409011381	Predicted neuraminidase (sialidase) [Carbohydrate transport and metabolism]; Region: COG4692
590409011382	BNR repeat-like domain; Region: BNR_2; pfam13088
590409011383	Domain of unknown function (DUF386); Region: DUF386; cl01047
590409011384	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
590409011385	classical (c) SDRs; Region: SDR_c; cd05233
590409011386	NAD(P) binding site [chemical binding]; other site
590409011387	active site
590409011388	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
590409011389	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
590409011390	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
590409011391	dimer interface [polypeptide binding]; other site
590409011392	putative CheW interface [polypeptide binding]; other site
590409011393	hypothetical protein; Provisional; Region: PRK05248
590409011394	bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238
590409011395	Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576
590409011396	substrate binding site [chemical binding]; other site
590409011397	Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581
590409011398	substrate binding site [chemical binding]; other site
590409011399	ligand binding site [chemical binding]; other site
590409011400	Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079
590409011401	Abhydrolase family; Region: Abhydrolase_7; pfam12715
590409011402	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
590409011403	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467
590409011404	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
590409011405	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
590409011406	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
590409011407	pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated; Region: aceF; PRK11854
590409011408	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
590409011409	E3 interaction surface; other site
590409011410	lipoyl attachment site [posttranslational modification]; other site
590409011411	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
590409011412	E3 interaction surface; other site
590409011413	lipoyl attachment site [posttranslational modification]; other site
590409011414	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
590409011415	E3 interaction surface; other site
590409011416	lipoyl attachment site [posttranslational modification]; other site
590409011417	e3 binding domain; Region: E3_binding; pfam02817
590409011418	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
590409011419	pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405
590409011420	Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017
590409011421	dimer interface [polypeptide binding]; other site
590409011422	TPP-binding site [chemical binding]; other site
590409011423	transcriptional regulator PdhR; Reviewed; Region: pdhR; PRK09464
590409011424	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
590409011425	DNA-binding site [nucleotide binding]; DNA binding site
590409011426	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
590409011427	aromatic amino acid transporter; Provisional; Region: PRK10238
590409011428	regulatory protein AmpE; Provisional; Region: PRK10987
590409011429	N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023
590409011430	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
590409011431	amidase catalytic site [active]
590409011432	substrate binding site [chemical binding]; other site
590409011433	Zn binding residues [ion binding]; other site
590409011434	nucleoside-specific channel-forming protein Tsx; Provisional; Region: PRK15106
590409011435	quinolinate phosphoribosyltransferase; Validated; Region: PRK09016
590409011436	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
590409011437	dimerization interface [polypeptide binding]; other site
590409011438	active site
590409011439	putative major pilin subunit; Provisional; Region: PRK10574
590409011440	Pilin (bacterial filament); Region: Pilin; pfam00114
590409011441	hypothetical protein; Provisional; Region: PRK10436
590409011442	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
590409011443	Walker A motif; other site
590409011444	ATP binding site [chemical binding]; other site
590409011445	Walker B motif; other site
590409011446	type IV pilin biogenesis protein; Provisional; Region: PRK10573
590409011447	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
590409011448	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
590409011449	guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05096
590409011450	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
590409011451	active site
590409011452	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
590409011453	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
590409011454	CoA-binding site [chemical binding]; other site
590409011455	ATP-binding [chemical binding]; other site
590409011456	hypothetical protein; Provisional; Region: PRK05287
590409011457	DNA gyrase inhibitor; Reviewed; Region: PRK00418
590409011458	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
590409011459	active site
590409011460	8-oxo-dGMP binding site [chemical binding]; other site
590409011461	nudix motif; other site
590409011462	metal binding site [ion binding]; metal-binding site
590409011463	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
590409011464	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
590409011465	SEC-C motif; Region: SEC-C; pfam02810
590409011466	SecA regulator SecM; Provisional; Region: PRK02943
590409011467	Protein of unknown function (DUF721); Region: DUF721; cl02324
590409011468	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186
590409011469	UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331
590409011470	cell division protein FtsZ; Validated; Region: PRK09330
590409011471	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
590409011472	nucleotide binding site [chemical binding]; other site
590409011473	SulA interaction site; other site
590409011474	cell division protein FtsA; Reviewed; Region: ftsA; PRK09472
590409011475	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
590409011476	Cell division protein FtsA; Region: FtsA; pfam14450
590409011477	cell division protein FtsQ; Provisional; Region: PRK10775
590409011478	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
590409011479	Cell division protein FtsQ; Region: FtsQ; pfam03799
590409011480	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
590409011481	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
590409011482	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
590409011483	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
590409011484	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
590409011485	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
590409011486	active site
590409011487	homodimer interface [polypeptide binding]; other site
590409011488	cell division protein FtsW; Provisional; Region: PRK10774
590409011489	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03806
590409011490	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
590409011491	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
590409011492	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
590409011493	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
590409011494	Mg++ binding site [ion binding]; other site
590409011495	putative catalytic motif [active]
590409011496	putative substrate binding site [chemical binding]; other site
590409011497	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed; Region: murF; PRK10773
590409011498	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
590409011499	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
590409011500	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
590409011501	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
590409011502	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
590409011503	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
590409011504	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
590409011505	peptidoglycan synthase FtsI; Provisional; Region: PRK15105
590409011506	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
590409011507	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
590409011508	cell division protein FtsL; Provisional; Region: PRK10772
590409011509	MraW methylase family; Region: Methyltransf_5; pfam01795
590409011510	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
590409011511	cell division protein MraZ; Reviewed; Region: PRK00326
590409011512	MraZ protein; Region: MraZ; pfam02381
590409011513	MraZ protein; Region: MraZ; pfam02381
590409011514	Protein of unknown function (DUF1144); Region: DUF1144; pfam06610
590409011515	DNA-binding transcriptional regulator FruR; Provisional; Region: PRK11303
590409011516	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
590409011517	DNA binding site [nucleotide binding]
590409011518	domain linker motif; other site
590409011519	Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274
590409011520	dimerization interface [polypeptide binding]; other site
590409011521	ligand binding site [chemical binding]; other site
590409011522	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
590409011523	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
590409011524	putative valine binding site [chemical binding]; other site
590409011525	dimer interface [polypeptide binding]; other site
590409011526	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
590409011527	acetolactate synthase 3 catalytic subunit; Validated; Region: PRK07979
590409011528	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
590409011529	PYR/PP interface [polypeptide binding]; other site
590409011530	dimer interface [polypeptide binding]; other site
590409011531	TPP binding site [chemical binding]; other site
590409011532	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
590409011533	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
590409011534	TPP-binding site [chemical binding]; other site
590409011535	dimer interface [polypeptide binding]; other site
590409011536	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
590409011537	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
590409011538	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
590409011539	acyl-activating enzyme (AAE) consensus motif; other site
590409011540	putative AMP binding site [chemical binding]; other site
590409011541	putative active site [active]
590409011542	putative CoA binding site [chemical binding]; other site
590409011543	2-isopropylmalate synthase; Validated; Region: PRK00915
590409011544	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
590409011545	active site
590409011546	catalytic residues [active]
590409011547	metal binding site [ion binding]; metal-binding site
590409011548	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502
590409011549	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
590409011550	tartrate dehydrogenase; Region: TTC; TIGR02089
590409011551	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
590409011552	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
590409011553	substrate binding site [chemical binding]; other site
590409011554	ligand binding site [chemical binding]; other site
590409011555	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
590409011556	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
590409011557	substrate binding site [chemical binding]; other site
590409011558	Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375
590409011559	Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193
590409011560	FAD binding pocket [chemical binding]; other site
590409011561	FAD binding motif [chemical binding]; other site
590409011562	phosphate binding motif [ion binding]; other site
590409011563	NAD binding pocket [chemical binding]; other site
590409011564	tryptophanase/L-cysteine desulfhydrase, PLP-dependent; Provisional; Region: tnaA; PRK13238
590409011565	Tryptophanase family (Tnase). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to tryptophanase (Tnase) and tyrosine phenol-lyase (TPL). Tnase and TPL are...; Region: Tnase_like; cd00617
590409011566	substrate binding site [chemical binding]; other site
590409011567	tetramer interface [polypeptide binding]; other site
590409011568	catalytic residue [active]
590409011569	transcriptional regulator SgrR; Provisional; Region: PRK13626
590409011570	Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793
590409011571	The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507
590409011572	thiamine transporter substrate binding subunit; Provisional; Region: tbpA; PRK11205
590409011573	ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143
590409011574	thiamine transporter membrane protein; Reviewed; Region: thiP; PRK09433
590409011575	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
590409011576	dimer interface [polypeptide binding]; other site
590409011577	conserved gate region; other site
590409011578	putative PBP binding loops; other site
590409011579	ABC-ATPase subunit interface; other site
590409011580	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
590409011581	dimer interface [polypeptide binding]; other site
590409011582	conserved gate region; other site
590409011583	putative PBP binding loops; other site
590409011584	ABC-ATPase subunit interface; other site
590409011585	thiamine transporter ATP-binding subunit; Provisional; Region: thiQ; PRK10771
590409011586	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
590409011587	Walker A/P-loop; other site
590409011588	ATP binding site [chemical binding]; other site
590409011589	Q-loop/lid; other site
590409011590	ABC transporter signature motif; other site
590409011591	Walker B; other site
590409011592	D-loop; other site
590409011593	H-loop/switch region; other site
590409011594	acetolactate synthase catalytic subunit; Validated; Region: PRK08155
590409011595	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
590409011596	PYR/PP interface [polypeptide binding]; other site
590409011597	dimer interface [polypeptide binding]; other site
590409011598	TPP binding site [chemical binding]; other site
590409011599	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
590409011600	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
590409011601	TPP-binding site [chemical binding]; other site
590409011602	dimer interface [polypeptide binding]; other site
590409011603	Acetolactate synthase, small (regulatory) subunit [Amino acid transport and metabolism]; Region: IlvH; COG0440
590409011604	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
590409011605	putative valine binding site [chemical binding]; other site
590409011606	dimer interface [polypeptide binding]; other site
590409011607	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
590409011608	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
590409011609	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
590409011610	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
590409011611	Protein of unknown function (DUF3380); Region: DUF3380; pfam11860
590409011612	type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344
590409011613	DNA polymerase II; Reviewed; Region: PRK05762
590409011614	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784
590409011615	active site
590409011616	catalytic site [active]
590409011617	substrate binding site [chemical binding]; other site
590409011618	DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537
590409011619	active site
590409011620	metal-binding site
590409011621	ATP-dependent helicase HepA; Validated; Region: PRK04914
590409011622	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
590409011623	ATP binding site [chemical binding]; other site
590409011624	putative Mg++ binding site [ion binding]; other site
590409011625	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
590409011626	nucleotide binding region [chemical binding]; other site
590409011627	ATP-binding site [chemical binding]; other site
590409011628	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
590409011629	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
590409011630	active site
590409011631	Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430
590409011632	N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316
590409011633	putative metal binding site [ion binding]; other site
590409011634	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
590409011635	HSP70 interaction site [polypeptide binding]; other site
590409011636	LPS assembly outer membrane complex protein LptD; Provisional; Region: PRK03761
590409011637	OstA-like protein; Region: OstA; cl00844
590409011638	OstA-like protein; Region: OstA; pfam03968
590409011639	Organic solvent tolerance protein; Region: OstA_C; pfam04453
590409011640	peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770
590409011641	SurA N-terminal domain; Region: SurA_N; pfam09312
590409011642	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
590409011643	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
590409011644	4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232
590409011645	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
590409011646	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
590409011647	Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030
590409011648	CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461
590409011649	diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166
590409011650	Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422
590409011651	active site
590409011652	metal binding site [ion binding]; metal-binding site
590409011653	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
590409011654	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
590409011655	folate binding site [chemical binding]; other site
590409011656	NADP+ binding site [chemical binding]; other site
590409011657	hypothetical protein; Provisional; Region: PRK09917
590409011658	Uncharacterized conserved protein [Function unknown]; Region: COG2966
590409011659	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
590409011660	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
590409011661	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
590409011662	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
590409011663	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
590409011664	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
590409011665	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
590409011666	ATP-grasp domain; Region: ATP-grasp_4; cl17255
590409011667	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
590409011668	IMP binding site; other site
590409011669	dimer interface [polypeptide binding]; other site
590409011670	interdomain contacts; other site
590409011671	partial ornithine binding site; other site
590409011672	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
590409011673	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
590409011674	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
590409011675	catalytic site [active]
590409011676	subunit interface [polypeptide binding]; other site
590409011677	Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289
590409011678	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
590409011679	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
590409011680	nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651
590409011681	active site
590409011682	tetramer interface [polypeptide binding]; other site
590409011683	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
590409011684	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
590409011685	FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095
590409011686	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
590409011687	lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376
590409011688	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
590409011689	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
590409011690	active site
590409011691	HIGH motif; other site
590409011692	nucleotide binding site [chemical binding]; other site
590409011693	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
590409011694	active site
590409011695	KMSKS motif; other site
590409011696	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
590409011697	tRNA binding surface [nucleotide binding]; other site
590409011698	anticodon binding site; other site
590409011699	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
590409011700	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
590409011701	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
590409011702	active site
590409011703	Riboflavin kinase; Region: Flavokinase; smart00904
590409011704	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
590409011705	transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062
590409011706	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
590409011707	The C-terminal substrate binding domain of LysR-type transcriptional activator of the nhaA gene, encoding Na+/H+ antiporter, contains the type 2 periplasmic binding fold; Region: PBP2_NhaR; cd08429
590409011708	putative dimerization interface [polypeptide binding]; other site
590409011709	pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09561
590409011710	chaperone protein DnaJ; Provisional; Region: PRK10767
590409011711	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
590409011712	HSP70 interaction site [polypeptide binding]; other site
590409011713	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
590409011714	substrate binding site [polypeptide binding]; other site
590409011715	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
590409011716	Zn binding sites [ion binding]; other site
590409011717	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
590409011718	dimer interface [polypeptide binding]; other site
590409011719	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
590409011720	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
590409011721	nucleotide binding site [chemical binding]; other site
590409011722	hypothetical protein; Provisional; Region: PRK10659
590409011723	metabolite-proton symporter; Region: 2A0106; TIGR00883
590409011724	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
590409011725	putative substrate translocation pore; other site
590409011726	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
590409011727	MPT binding site; other site
590409011728	trimer interface [polypeptide binding]; other site
590409011729	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
590409011730	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
590409011731	metal binding site [ion binding]; metal-binding site
590409011732	active site
590409011733	I-site; other site
590409011734	transaldolase-like protein; Provisional; Region: PTZ00411
590409011735	Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957
590409011736	active site
590409011737	dimer interface [polypeptide binding]; other site
590409011738	catalytic residue [active]
590409011739	hypothetical protein; Validated; Region: PRK02101
590409011740	threonine synthase; Validated; Region: PRK09225
590409011741	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
590409011742	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
590409011743	catalytic residue [active]
590409011744	homoserine kinase; Provisional; Region: PRK01212
590409011745	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
590409011746	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
590409011747	bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436
590409011748	AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257
590409011749	putative catalytic residues [active]
590409011750	putative nucleotide binding site [chemical binding]; other site
590409011751	putative aspartate binding site [chemical binding]; other site
590409011752	ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921
590409011753	dimer interface [polypeptide binding]; other site
590409011754	putative threonine allosteric regulatory site; other site
590409011755	ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922
590409011756	putative threonine allosteric regulatory site; other site
590409011757	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
590409011758	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
590409011759	putative RNA methyltransferase; Provisional; Region: PRK10433
590409011760	RNA methyltransferase, TrmH family, group 1; Region: rRNA_methyl_1; TIGR00050
590409011761	two-component response regulator; Provisional; Region: PRK11173
590409011762	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
590409011763	active site
590409011764	phosphorylation site [posttranslational modification]
590409011765	intermolecular recognition site; other site
590409011766	dimerization interface [polypeptide binding]; other site
590409011767	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
590409011768	DNA binding site [nucleotide binding]
590409011769	hypothetical protein; Provisional; Region: PRK10756
590409011770	CreA protein; Region: CreA; pfam05981
590409011771	right oriC-binding transcriptional activator; Provisional; Region: PRK15121
590409011772	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
590409011773	GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445
590409011774	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
590409011775	catalytic core [active]
590409011776	inosine/xanthosine triphosphatase; Reviewed; Region: PRK05074
590409011777	Trp operon repressor; Provisional; Region: PRK01381
590409011778	lytic murein transglycosylase; Provisional; Region: PRK11619
590409011779	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
590409011780	N-acetyl-D-glucosamine binding site [chemical binding]; other site
590409011781	catalytic residue [active]
590409011782	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
590409011783	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
590409011784	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
590409011785	ABC transporter; Region: ABC_tran_2; pfam12848
590409011786	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
590409011787	Tar ligand binding domain homologue; Region: TarH; pfam02203
590409011788	dimer interface [polypeptide binding]; other site
590409011789	ligand binding site [chemical binding]; other site
590409011790	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
590409011791	dimerization interface [polypeptide binding]; other site
590409011792	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
590409011793	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
590409011794	dimer interface [polypeptide binding]; other site
590409011795	putative CheW interface [polypeptide binding]; other site
590409011796	LysR family transcriptional regulator; Provisional; Region: PRK14997
590409011797	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
590409011798	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
590409011799	putative effector binding pocket; other site
590409011800	dimerization interface [polypeptide binding]; other site
590409011801	Arginate lyase and other MDR family members; Region: AL_MDR; cd08252
590409011802	zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817
590409011803	putative NAD(P) binding site [chemical binding]; other site
590409011804	dimer interface [polypeptide binding]; other site
590409011805	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790
590409011806	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176
590409011807	ligand binding site [chemical binding]; other site
590409011808	NAD binding site [chemical binding]; other site
590409011809	tetramer interface [polypeptide binding]; other site
590409011810	catalytic site [active]
590409011811	C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901
590409011812	L-serine binding site [chemical binding]; other site
590409011813	ACT domain interface; other site
590409011814	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
590409011815	tetramer (dimer of dimers) interface [polypeptide binding]; other site
590409011816	active site
590409011817	dimer interface [polypeptide binding]; other site
590409011818	chromosome replication initiation inhibitor protein; Validated; Region: PRK03635
590409011819	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
590409011820	The C-terminal substrate binding domain of LysR-type transcriptional regulator, ArgP (IciA), for arginine exporter (ArgO); contains the type 2 periplasmic binding fold; Region: PBP2_IciA_ArgP; cd08428
590409011821	putative dimerization interface [polypeptide binding]; other site
590409011822	Uncharacterized conserved protein [Function unknown]; Region: COG2968
590409011823	oxidative stress defense protein; Provisional; Region: PRK11087
590409011824	Transcriptional regulator [Transcription]; Region: IclR; COG1414
590409011825	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
590409011826	Bacterial transcriptional regulator; Region: IclR; pfam01614
590409011827	mechanosensitive channel MscS; Provisional; Region: PRK10334
590409011828	Conserved TM helix; Region: TM_helix; pfam05552
590409011829	Mechanosensitive ion channel; Region: MS_channel; pfam00924
590409011830	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
590409011831	Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946
590409011832	active site
590409011833	intersubunit interface [polypeptide binding]; other site
590409011834	zinc binding site [ion binding]; other site
590409011835	Na+ binding site [ion binding]; other site
590409011836	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
590409011837	Phosphoglycerate kinase; Region: PGK; pfam00162
590409011838	substrate binding site [chemical binding]; other site
590409011839	hinge regions; other site
590409011840	ADP binding site [chemical binding]; other site
590409011841	catalytic site [active]
590409011842	erythrose 4-phosphate dehydrogenase; Provisional; Region: PRK13535
590409011843	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
590409011844	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
590409011845	transketolase; Reviewed; Region: PRK12753
590409011846	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
590409011847	TPP-binding site [chemical binding]; other site
590409011848	dimer interface [polypeptide binding]; other site
590409011849	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
590409011850	PYR/PP interface [polypeptide binding]; other site
590409011851	dimer interface [polypeptide binding]; other site
590409011852	TPP binding site [chemical binding]; other site
590409011853	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
590409011854	putative transporter; Provisional; Region: PRK03699
590409011855	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
590409011856	putative substrate translocation pore; other site
590409011857	arginine decarboxylase; Provisional; Region: PRK05354
590409011858	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830
590409011859	dimer interface [polypeptide binding]; other site
590409011860	active site
590409011861	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
590409011862	catalytic residues [active]
590409011863	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
590409011864	S-adenosylmethionine synthetase; Validated; Region: PRK05250
590409011865	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
590409011866	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
590409011867	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
590409011868	hypothetical protein; Provisional; Region: PRK04860
590409011869	Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091
590409011870	DNA-specific endonuclease I; Provisional; Region: PRK15137
590409011871	Endonuclease I [DNA replication, recombination, and repair]; Region: EndA; COG2356
590409011872	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385
590409011873	RNA methyltransferase, RsmE family; Region: TIGR00046
590409011874	glutathione synthetase; Provisional; Region: PRK05246
590409011875	Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951
590409011876	Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955
590409011877	hypothetical protein; Validated; Region: PRK00228
590409011878	Holliday junction resolvase-like protein; Reviewed; Region: PRK00109
590409011879	Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate  into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354
590409011880	AMP binding site [chemical binding]; other site
590409011881	metal binding site [ion binding]; metal-binding site
590409011882	active site
590409011883	UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081
590409011884	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
590409011885	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
590409011886	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
590409011887	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
590409011888	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
590409011889	GDP-binding site [chemical binding]; other site
590409011890	ACT binding site; other site
590409011891	IMP binding site; other site
590409011892	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3242
590409011893	FtsH protease regulator HflC; Provisional; Region: PRK11029
590409011894	Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405
590409011895	FtsH protease regulator HflK; Provisional; Region: PRK10930
590409011896	Bacterial membrane protein N terminal; Region: HflK_N; pfam12221
590409011897	Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404
590409011898	GTPase HflX; Provisional; Region: PRK11058
590409011899	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
590409011900	HflX GTPase family; Region: HflX; cd01878
590409011901	G1 box; other site
590409011902	GTP/Mg2+ binding site [chemical binding]; other site
590409011903	Switch I region; other site
590409011904	G2 box; other site
590409011905	G3 box; other site
590409011906	Switch II region; other site
590409011907	G4 box; other site
590409011908	G5 box; other site
590409011909	bacterial Hfq-like; Region: Hfq; cd01716
590409011910	hexamer interface [polypeptide binding]; other site
590409011911	Sm1 motif; other site
590409011912	RNA binding site [nucleotide binding]; other site
590409011913	Sm2 motif; other site
590409011914	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
590409011915	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
590409011916	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
590409011917	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
590409011918	ATP binding site [chemical binding]; other site
590409011919	Mg2+ binding site [ion binding]; other site
590409011920	G-X-G motif; other site
590409011921	MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL.  EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family.  This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482
590409011922	ATP binding site [chemical binding]; other site
590409011923	MutL C terminal dimerisation domain; Region: MutL_C; cl07336
590409011924	AMIN domain; Region: AMIN; pfam11741
590409011925	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
590409011926	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
590409011927	active site
590409011928	metal binding site [ion binding]; metal-binding site
590409011929	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
590409011930	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
590409011931	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
590409011932	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
590409011933	Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520
590409011934	putative carbohydrate kinase; Provisional; Region: PRK10565
590409011935	Uncharacterized conserved protein [Function unknown]; Region: COG0062
590409011936	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
590409011937	putative substrate binding site [chemical binding]; other site
590409011938	putative ATP binding site [chemical binding]; other site
590409011939	epoxyqueuosine reductase; Region: TIGR00276
590409011940	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
590409011941	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
590409011942	Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300
590409011943	NAD binding site [chemical binding]; other site
590409011944	ligand binding site [chemical binding]; other site
590409011945	catalytic site [active]
590409011946	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
590409011947	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
590409011948	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
590409011949	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
590409011950	active site
590409011951	non-prolyl cis peptide bond; other site
590409011952	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
590409011953	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
590409011954	substrate binding pocket [chemical binding]; other site
590409011955	membrane-bound complex binding site; other site
590409011956	hinge residues; other site
590409011957	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
590409011958	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
590409011959	substrate binding pocket [chemical binding]; other site
590409011960	membrane-bound complex binding site; other site
590409011961	hinge residues; other site
590409011962	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
590409011963	Coenzyme A binding pocket [chemical binding]; other site
590409011964	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
590409011965	dimer interface [polypeptide binding]; other site
590409011966	conserved gate region; other site
590409011967	putative PBP binding loops; other site
590409011968	ABC-ATPase subunit interface; other site
590409011969	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
590409011970	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
590409011971	Walker A/P-loop; other site
590409011972	ATP binding site [chemical binding]; other site
590409011973	Q-loop/lid; other site
590409011974	ABC transporter signature motif; other site
590409011975	Walker B; other site
590409011976	D-loop; other site
590409011977	H-loop/switch region; other site
590409011978	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
590409011979	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
590409011980	peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561
590409011981	Transcriptional regulators [Transcription]; Region: MarR; COG1846
590409011982	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
590409011983	putative Zn2+ binding site [ion binding]; other site
590409011984	putative DNA binding site [nucleotide binding]; other site
590409011985	methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048
590409011986	ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144
590409011987	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
590409011988	dimerization interface [polypeptide binding]; other site
590409011989	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
590409011990	dimer interface [polypeptide binding]; other site
590409011991	putative CheW interface [polypeptide binding]; other site
590409011992	methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041
590409011993	ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181
590409011994	dimer interface [polypeptide binding]; other site
590409011995	ligand binding site [chemical binding]; other site
590409011996	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
590409011997	dimer interface [polypeptide binding]; other site
590409011998	putative CheW interface [polypeptide binding]; other site
590409011999	Outer membrane efflux protein; Region: OEP; pfam02321
590409012000	Outer membrane efflux protein; Region: OEP; pfam02321
590409012001	Domain of unknown function (DUF4347); Region: DUF4347; pfam14252
590409012002	Dystroglycan-type cadherin-like domains; Region: CADG; smart00736
590409012003	Cadherin repeat-like domain; Region: CA_like; cl15786
590409012004	Ca2+ binding site [ion binding]; other site
590409012005	Dystroglycan-type cadherin-like domains; Region: CADG; smart00736
590409012006	Cadherin repeat-like domain; Region: CA_like; cl15786
590409012007	Ca2+ binding site [ion binding]; other site
590409012008	Dystroglycan-type cadherin-like domains; Region: CADG; smart00736
590409012009	Cadherin repeat-like domain; Region: CA_like; cl15786
590409012010	Phage Tail Collar Domain; Region: Collar; pfam07484
590409012011	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cd05709
590409012012	Peptidase family M50; Region: Peptidase_M50; pfam02163
590409012013	active site
590409012014	Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845
590409012015	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
590409012016	HlyD family secretion protein; Region: HlyD_3; pfam13437
590409012017	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
590409012018	HlyD family secretion protein; Region: HlyD_3; pfam13437
590409012019	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
590409012020	HlyD family secretion protein; Region: HlyD_3; pfam13437
590409012021	DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135
590409012022	catalytic site [active]
590409012023	putative active site [active]
590409012024	putative substrate binding site [chemical binding]; other site
590409012025	dimer interface [polypeptide binding]; other site
590409012026	GTPase RsgA; Reviewed; Region: PRK12288
590409012027	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
590409012028	RNA binding site [nucleotide binding]; other site
590409012029	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
590409012030	GTPase/Zn-binding domain interface [polypeptide binding]; other site
590409012031	GTP/Mg2+ binding site [chemical binding]; other site
590409012032	G4 box; other site
590409012033	G5 box; other site
590409012034	G1 box; other site
590409012035	Switch I region; other site
590409012036	G2 box; other site
590409012037	G3 box; other site
590409012038	Switch II region; other site
590409012039	phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044
590409012040	putative mechanosensitive channel protein; Provisional; Region: PRK10929
590409012041	Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794
590409012042	Mechanosensitive ion channel; Region: MS_channel; pfam00924
590409012043	poxB regulator PoxA; Provisional; Region: PRK09350
590409012044	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
590409012045	motif 1; other site
590409012046	dimer interface [polypeptide binding]; other site
590409012047	active site
590409012048	motif 2; other site
590409012049	motif 3; other site
590409012050	fumarate reductase flavoprotein subunit; Validated; Region: PRK09231
590409012051	L-aspartate oxidase; Provisional; Region: PRK06175
590409012052	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
590409012053	fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12385
590409012054	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
590409012055	Quinol:fumarate reductase (QFR) Type D subfamily, 15kD hydrophobic subunit C;  QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitC; cd00546
590409012056	D-subunit interface [polypeptide binding]; other site
590409012057	Iron-sulfur protein interface; other site
590409012058	proximal quinone binding site [chemical binding]; other site
590409012059	Quinol:fumarate reductase (QFR) Type D subfamily, 13kD hydrophobic subunit D; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitD; cd00547
590409012060	Iron-sulfur protein interface; other site
590409012061	proximal quinone binding site [chemical binding]; other site
590409012062	C-subunit interface; other site
590409012063	distal quinone binding site; other site
590409012064	outer membrane lipoprotein Blc; Provisional; Region: PRK10477
590409012065	Lipocalin-like domain; Region: Lipocalin_2; pfam08212
590409012066	Protein of unknown function, DUF486; Region: DUF486; cl01236
590409012067	elongation factor P; Validated; Region: PRK00529
590409012068	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
590409012069	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
590409012070	RNA binding site [nucleotide binding]; other site
590409012071	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
590409012072	RNA binding site [nucleotide binding]; other site
590409012073	Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509
590409012074	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
590409012075	FeS/SAM binding site; other site
590409012076	Domain of unknown function (DUF4156); Region: DUF4156; pfam13698
590409012077	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
590409012078	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
590409012079	active site
590409012080	dimer interface [polypeptide binding]; other site
590409012081	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
590409012082	dimer interface [polypeptide binding]; other site
590409012083	active site
590409012084	aspartate kinase III; Validated; Region: PRK09084
590409012085	AAK_AKiii-LysC-EC: Amino Acid Kinase Superfamily (AAK), AKiii-LysC-EC: this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKIII. AKIII is a monofunctional class enzyme (LysC) found in some...; Region: AAK_AKiii-LysC-EC; cd04258
590409012086	nucleotide binding site [chemical binding]; other site
590409012087	putative catalytic residues [active]
590409012088	aspartate binding site [chemical binding]; other site
590409012089	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
590409012090	ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_2; cd04917
590409012091	dimer interface [polypeptide binding]; other site
590409012092	Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283
590409012093	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
590409012094	PhoU domain; Region: PhoU; pfam01895
590409012095	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
590409012096	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625
590409012097	transmembrane helices; other site
590409012098	B12-dependent methionine synthase; Provisional; Region: metH; PRK09490
590409012099	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
590409012100	MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  Cobalamin-dependent...; Region: MeTr; cd00740
590409012101	substrate binding pocket [chemical binding]; other site
590409012102	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
590409012103	B12 binding site [chemical binding]; other site
590409012104	cobalt ligand [ion binding]; other site
590409012105	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
590409012106	transcriptional repressor IclR; Provisional; Region: PRK11569
590409012107	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
590409012108	Bacterial transcriptional regulator; Region: IclR; pfam01614
590409012109	Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579
590409012110	bifunctional isocitrate dehydrogenase kinase/phosphatase protein; Validated; Region: aceK; PRK02946
590409012111	isocitrate lyase; Provisional; Region: PRK15063
590409012112	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
590409012113	tetramer interface [polypeptide binding]; other site
590409012114	active site
590409012115	Mg2+/Mn2+ binding site [ion binding]; other site
590409012116	Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727
590409012117	malate synthase A; Region: malate_syn_A; TIGR01344
590409012118	active site
590409012119	homoserine O-succinyltransferase; Provisional; Region: PRK05368
590409012120	Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131
590409012121	proposed active site lysine [active]
590409012122	conserved cys residue [active]
590409012123	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
590409012124	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
590409012125	trimer interface [polypeptide binding]; other site
590409012126	putative metal binding site [ion binding]; other site
590409012127	Protein of unknown function (DUF1488); Region: DUF1488; pfam07369
590409012128	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
590409012129	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
590409012130	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
590409012131	shikimate binding site; other site
590409012132	NAD(P) binding site [chemical binding]; other site
590409012133	Telomere recombination; Region: Sua5_yciO_yrdC; cl00305
590409012134	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
590409012135	Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551
590409012136	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
590409012137	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
590409012138	hypothetical protein; Validated; Region: PRK03430
590409012139	hypothetical protein; Provisional; Region: PRK10736
590409012140	DNA protecting protein DprA; Region: dprA; TIGR00732
590409012141	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
590409012142	active site
590409012143	catalytic residues [active]
590409012144	metal binding site [ion binding]; metal-binding site
590409012145	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
590409012146	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
590409012147	putative active site [active]
590409012148	substrate binding site [chemical binding]; other site
590409012149	putative cosubstrate binding site; other site
590409012150	catalytic site [active]
590409012151	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
590409012152	substrate binding site [chemical binding]; other site
590409012153	16S rRNA methyltransferase B; Provisional; Region: PRK10901
590409012154	N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620
590409012155	putative RNA binding site [nucleotide binding]; other site
590409012156	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
590409012157	S-adenosylmethionine binding site [chemical binding]; other site
590409012158	potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496
590409012159	TrkA-N domain; Region: TrkA_N; pfam02254
590409012160	TrkA-C domain; Region: TrkA_C; pfam02080
590409012161	TrkA-N domain; Region: TrkA_N; pfam02254
590409012162	TrkA-C domain; Region: TrkA_C; pfam02080
590409012163	Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970
590409012164	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
590409012165	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3036
590409012166	hypothetical protein; Provisional; Region: PRK10203
590409012167	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
590409012168	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
590409012169	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
590409012170	alphaNTD homodimer interface [polypeptide binding]; other site
590409012171	alphaNTD - beta interaction site [polypeptide binding]; other site
590409012172	alphaNTD - beta' interaction site [polypeptide binding]; other site
590409012173	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
590409012174	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
590409012175	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
590409012176	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
590409012177	RNA binding surface [nucleotide binding]; other site
590409012178	30S ribosomal protein S11; Validated; Region: PRK05309
590409012179	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
590409012180	30S ribosomal protein S13; Region: bact_S13; TIGR03631
590409012181	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
590409012182	SecY translocase; Region: SecY; pfam00344
590409012183	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
590409012184	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
590409012185	23S rRNA binding site [nucleotide binding]; other site
590409012186	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
590409012187	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
590409012188	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
590409012189	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
590409012190	5S rRNA interface [nucleotide binding]; other site
590409012191	23S rRNA interface [nucleotide binding]; other site
590409012192	L5 interface [polypeptide binding]; other site
590409012193	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
590409012194	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
590409012195	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
590409012196	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
590409012197	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
590409012198	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
590409012199	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
590409012200	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
590409012201	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
590409012202	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
590409012203	RNA binding site [nucleotide binding]; other site
590409012204	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
590409012205	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
590409012206	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
590409012207	23S rRNA interface [nucleotide binding]; other site
590409012208	putative translocon interaction site; other site
590409012209	signal recognition particle (SRP54) interaction site; other site
590409012210	L23 interface [polypeptide binding]; other site
590409012211	trigger factor interaction site; other site
590409012212	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
590409012213	23S rRNA interface [nucleotide binding]; other site
590409012214	5S rRNA interface [nucleotide binding]; other site
590409012215	putative antibiotic binding site [chemical binding]; other site
590409012216	L25 interface [polypeptide binding]; other site
590409012217	L27 interface [polypeptide binding]; other site
590409012218	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
590409012219	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
590409012220	G-X-X-G motif; other site
590409012221	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
590409012222	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
590409012223	protein-rRNA interface [nucleotide binding]; other site
590409012224	putative translocon binding site; other site
590409012225	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
590409012226	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
590409012227	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
590409012228	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
590409012229	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
590409012230	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
590409012231	50S ribosomal protein L3, bacterial; Region: L3_bact; TIGR03625
590409012232	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
590409012233	Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193
590409012234	Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907
590409012235	heme binding site [chemical binding]; other site
590409012236	ferroxidase pore; other site
590409012237	ferroxidase diiron center [ion binding]; other site
590409012238	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093
590409012239	elongation factor Tu; Reviewed; Region: PRK00049
590409012240	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
590409012241	G1 box; other site
590409012242	GEF interaction site [polypeptide binding]; other site
590409012243	GTP/Mg2+ binding site [chemical binding]; other site
590409012244	Switch I region; other site
590409012245	G2 box; other site
590409012246	G3 box; other site
590409012247	Switch II region; other site
590409012248	G4 box; other site
590409012249	G5 box; other site
590409012250	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
590409012251	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
590409012252	Antibiotic Binding Site [chemical binding]; other site
590409012253	elongation factor G; Reviewed; Region: PRK00007
590409012254	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
590409012255	G1 box; other site
590409012256	putative GEF interaction site [polypeptide binding]; other site
590409012257	GTP/Mg2+ binding site [chemical binding]; other site
590409012258	Switch I region; other site
590409012259	G2 box; other site
590409012260	G3 box; other site
590409012261	Switch II region; other site
590409012262	G4 box; other site
590409012263	G5 box; other site
590409012264	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
590409012265	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
590409012266	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
590409012267	30S ribosomal protein S7; Validated; Region: PRK05302
590409012268	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
590409012269	S17 interaction site [polypeptide binding]; other site
590409012270	S8 interaction site; other site
590409012271	16S rRNA interaction site [nucleotide binding]; other site
590409012272	streptomycin interaction site [chemical binding]; other site
590409012273	23S rRNA interaction site [nucleotide binding]; other site
590409012274	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
590409012275	sulfur transfer complex subunit TusB; Provisional; Region: PRK13510
590409012276	sulfur relay protein TusC; Validated; Region: PRK00211
590409012277	sulfur transfer complex subunit TusD; Validated; Region: PRK00207
590409012278	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964
590409012279	YheO-like PAS domain; Region: PAS_6; pfam08348
590409012280	HTH domain; Region: HTH_22; pfam13309
590409012281	putative metal dependent hydrolase; Provisional; Region: PRK11598
590409012282	Domain of unknown function (DUF1705); Region: DUF1705; pfam08019
590409012283	Sulfatase; Region: Sulfatase; pfam00884
590409012284	DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643
590409012285	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
590409012286	active site
590409012287	phosphorylation site [posttranslational modification]
590409012288	intermolecular recognition site; other site
590409012289	dimerization interface [polypeptide binding]; other site
590409012290	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
590409012291	DNA binding site [nucleotide binding]
590409012292	sensor protein BasS/PmrB; Provisional; Region: PRK10755
590409012293	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
590409012294	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
590409012295	dimer interface [polypeptide binding]; other site
590409012296	phosphorylation site [posttranslational modification]
590409012297	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
590409012298	ATP binding site [chemical binding]; other site
590409012299	Mg2+ binding site [ion binding]; other site
590409012300	G-X-G motif; other site
590409012301	FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK10902
590409012302	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
590409012303	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
590409012304	SlyX; Region: SlyX; cl01090
590409012305	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
590409012306	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
590409012307	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
590409012308	Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334
590409012309	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
590409012310	active site
590409012311	substrate binding site [chemical binding]; other site
590409012312	ATP binding site [chemical binding]; other site
590409012313	ethanolamine permease; Region: 2A0305; TIGR00908
590409012314	FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095
590409012315	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
590409012316	Probable metal-binding protein (DUF2387); Region: DUF2387; pfam09526
590409012317	glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659
590409012318	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
590409012319	TrkA-N domain; Region: TrkA_N; pfam02254
590409012320	glutathione-regulated potassium-efflux system ancillary protein KefG; Provisional; Region: PRK04930
590409012321	putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636
590409012322	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
590409012323	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
590409012324	ABC transporter; Region: ABC_tran_2; pfam12848
590409012325	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
590409012326	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
590409012327	putative hydrolase; Provisional; Region: PRK10985
590409012328	hypothetical protein; Provisional; Region: PRK04966
590409012329	phosphoribulokinase; Provisional; Region: PRK15453
590409012330	active site
590409012331	hypothetical protein; Provisional; Region: PRK10738
590409012332	DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753
590409012333	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
590409012334	ligand binding site [chemical binding]; other site
590409012335	flexible hinge region; other site
590409012336	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
590409012337	putative switch regulator; other site
590409012338	non-specific DNA interactions [nucleotide binding]; other site
590409012339	DNA binding site [nucleotide binding]
590409012340	sequence specific DNA binding site [nucleotide binding]; other site
590409012341	putative cAMP binding site [chemical binding]; other site
590409012342	bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093
590409012343	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
590409012344	inhibitor-cofactor binding pocket; inhibition site
590409012345	pyridoxal 5'-phosphate binding site [chemical binding]; other site
590409012346	catalytic residue [active]
590409012347	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
590409012348	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
590409012349	glutamine binding [chemical binding]; other site
590409012350	catalytic triad [active]
590409012351	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
590409012352	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
590409012353	non-specific DNA binding site [nucleotide binding]; other site
590409012354	salt bridge; other site
590409012355	sequence-specific DNA binding site [nucleotide binding]; other site
590409012356	Winged helix-turn-helix DNA-binding; Region: HTH_35; pfam13693
590409012357	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4643
590409012358	Zinc-binding domain of primase-helicase; Region: Prim_Zn_Ribbon; smart00778
590409012359	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
590409012360	AAA domain; Region: AAA_25; pfam13481
590409012361	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
590409012362	ATP binding site [chemical binding]; other site
590409012363	Walker B motif; other site
590409012364	Ash protein family; Region: Phage_ASH; pfam10554
590409012365	Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311
590409012366	Phage integrase, N-terminal; Region: Integrase_l_N; pfam12834
590409012367	Integrase; Region: Integrase_1; pfam12835
590409012368	ParB-like nuclease domain; Region: ParB; smart00470
590409012369	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338
590409012370	integrase; Provisional; Region: PRK09692
590409012371	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
590409012372	active site
590409012373	Int/Topo IB signature motif; other site
590409012374	Helix-turn-helix domain; Region: HTH_18; pfam12833
590409012375	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
590409012376	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
590409012377	active site
590409012378	catalytic residues [active]
590409012379	cyanobactin maturation protease, PatA/PatG family; Region: protease_PatA; TIGR03895
590409012380	Predicted chitinase [General function prediction only]; Region: COG3179
590409012381	catalytic residue [active]
590409012382	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
590409012383	Major Facilitator Superfamily; Region: MFS_1; pfam07690
590409012384	putative substrate translocation pore; other site
590409012385	Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290
590409012386	Neurotransmitter-gated ion-channel ligand binding domain; Region: Neur_chan_LBD; pfam02931
590409012387	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
590409012388	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
590409012389	catalytic residue [active]
590409012390	Pectate lyase; Region: Pec_lyase_C; pfam00544
590409012391	Pectate lyase; Region: Pec_lyase_C; cl01593
590409012392	Pectate lyase; Region: Pec_lyase_C; cl01593
590409012393	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
590409012394	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
590409012395	metal binding site [ion binding]; metal-binding site
590409012396	active site
590409012397	I-site; other site
590409012398	Hemerythrin; Region: Hemerythrin; cd12107
590409012399	peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903
590409012400	cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920
590409012401	substrate binding site [chemical binding]; other site
590409012402	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
590409012403	Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 4. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_4; cd03329
590409012404	putative active site pocket [active]
590409012405	metal binding site [ion binding]; metal-binding site
590409012406	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
590409012407	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
590409012408	active site
590409012409	HIGH motif; other site
590409012410	dimer interface [polypeptide binding]; other site
590409012411	KMSKS motif; other site
590409012412	phosphoglycolate phosphatase; Provisional; Region: PRK13222
590409012413	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
590409012414	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
590409012415	motif II; other site
590409012416	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
590409012417	ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163
590409012418	substrate binding site [chemical binding]; other site
590409012419	hexamer interface [polypeptide binding]; other site
590409012420	metal binding site [ion binding]; metal-binding site
590409012421	D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344
590409012422	hypothetical protein; Reviewed; Region: PRK11901
590409012423	cell division protein DamX; Validated; Region: PRK10905
590409012424	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
590409012425	active site
590409012426	dimer interface [polypeptide binding]; other site
590409012427	metal binding site [ion binding]; metal-binding site
590409012428	shikimate kinase; Reviewed; Region: aroK; PRK00131
590409012429	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
590409012430	ADP binding site [chemical binding]; other site
590409012431	magnesium binding site [ion binding]; other site
590409012432	putative shikimate binding site; other site
590409012433	putative outer membrane porin HofQ; Provisional; Region: hofQ; PRK13568
590409012434	Secretin and TonB N terminus short domain; Region: STN; smart00965
590409012435	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
590409012436	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
590409012437	Protein of unknown function (DUF2531); Region: DUF2531; pfam10748
590409012438	Fimbrial assembly protein (PilN); Region: PilN; pfam05137
590409012439	Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972
590409012440	penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636
590409012441	Transglycosylase; Region: Transgly; pfam00912
590409012442	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
590409012443	adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762
590409012444	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
590409012445	ADP-ribose binding site [chemical binding]; other site
590409012446	dimer interface [polypeptide binding]; other site
590409012447	active site
590409012448	nudix motif; other site
590409012449	metal binding site [ion binding]; metal-binding site
590409012450	Intracellular growth attenuator protein IgaA; Region: IgaA; pfam07095
590409012451	haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509
590409012452	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
590409012453	motif II; other site
590409012454	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
590409012455	RNA binding surface [nucleotide binding]; other site
590409012456	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
590409012457	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
590409012458	dimerization interface [polypeptide binding]; other site
590409012459	domain crossover interface; other site
590409012460	redox-dependent activation switch; other site
590409012461	Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293
590409012462	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484
590409012463	active site
590409012464	substrate-binding site [chemical binding]; other site
590409012465	metal-binding site [ion binding]
590409012466	ATP binding site [chemical binding]; other site
590409012467	osmolarity sensor protein; Provisional; Region: envZ; PRK09467
590409012468	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
590409012469	dimerization interface [polypeptide binding]; other site
590409012470	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
590409012471	dimer interface [polypeptide binding]; other site
590409012472	phosphorylation site [posttranslational modification]
590409012473	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
590409012474	ATP binding site [chemical binding]; other site
590409012475	G-X-G motif; other site
590409012476	osmolarity response regulator; Provisional; Region: ompR; PRK09468
590409012477	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
590409012478	active site
590409012479	phosphorylation site [posttranslational modification]
590409012480	intermolecular recognition site; other site
590409012481	dimerization interface [polypeptide binding]; other site
590409012482	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
590409012483	DNA binding site [nucleotide binding]
590409012484	transcription elongation factor GreB; Reviewed; Region: greB; PRK01885
590409012485	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
590409012486	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
590409012487	Sulfatase; Region: Sulfatase; cl17466
590409012488	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ACT14924; Region: LPLAT_ACT14924-like; cd07986
590409012489	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
590409012490	putative acyl-acceptor binding pocket; other site
590409012491	Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444
590409012492	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
590409012493	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
590409012494	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
590409012495	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
590409012496	RNA binding site [nucleotide binding]; other site
590409012497	Protein of unknown function (DUF1493); Region: DUF1493; pfam07377
590409012498	type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344
590409012499	carboxylesterase BioH; Provisional; Region: PRK10349
590409012500	DNA utilization protein GntX; Provisional; Region: PRK11595
590409012501	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
590409012502	active site
590409012503	Fe/S biogenesis protein NfuA; Provisional; Region: PRK11190
590409012504	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
590409012505	Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694
590409012506	4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052
590409012507	4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640
590409012508	maltodextrin phosphorylase; Provisional; Region: PRK14985
590409012509	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
590409012510	active site pocket [active]
590409012511	DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906
590409012512	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
590409012513	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
590409012514	intramembrane serine protease GlpG; Provisional; Region: PRK10907
590409012515	Protein of unknown function (DUF3582); Region: DUF3582; pfam12122
590409012516	Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
590409012517	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
590409012518	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
590409012519	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
590409012520	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
590409012521	substrate binding site [chemical binding]; other site
590409012522	dimer interface [polypeptide binding]; other site
590409012523	ATP binding site [chemical binding]; other site
590409012524	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
590409012525	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
590409012526	inhibitor site; inhibition site
590409012527	active site
590409012528	dimer interface [polypeptide binding]; other site
590409012529	catalytic residue [active]
590409012530	Domain of unknown function (DUF386); Region: DUF386; pfam04074
590409012531	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
590409012532	D-galactonate transporter; Region: 2A0114; TIGR00893
590409012533	putative substrate translocation pore; other site
590409012534	GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444
590409012535	active site residue [active]
590409012536	glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266
590409012537	glycogen phosphorylase; Provisional; Region: PRK14986
590409012538	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
590409012539	homodimer interface [polypeptide binding]; other site
590409012540	active site pocket [active]
590409012541	glycogen synthase; Provisional; Region: glgA; PRK00654
590409012542	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
590409012543	ADP-binding pocket [chemical binding]; other site
590409012544	homodimer interface [polypeptide binding]; other site
590409012545	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725
590409012546	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
590409012547	ligand binding site; other site
590409012548	oligomer interface; other site
590409012549	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
590409012550	N-terminal domain interface [polypeptide binding]; other site
590409012551	sulfate 1 binding site; other site
590409012552	glycogen debranching enzyme; Provisional; Region: PRK03705
590409012553	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
590409012554	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
590409012555	active site
590409012556	catalytic site [active]
590409012557	glycogen branching enzyme; Provisional; Region: PRK05402
590409012558	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
590409012559	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
590409012560	active site
590409012561	catalytic site [active]
590409012562	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
590409012563	Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275
590409012564	5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694
590409012565	Histidine kinase; Region: His_kinase; pfam06580
590409012566	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
590409012567	ATP binding site [chemical binding]; other site
590409012568	Mg2+ binding site [ion binding]; other site
590409012569	G-X-G motif; other site
590409012570	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
590409012571	DNA-binding site [nucleotide binding]; DNA binding site
590409012572	RNA-binding motif; other site
590409012573	nickel responsive regulator; Provisional; Region: PRK02967
590409012574	NikR C terminal nickel binding domain; Region: NikR_C; pfam08753
590409012575	aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598
590409012576	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
590409012577	putative antibiotic transporter; Provisional; Region: PRK10739
590409012578	high-affinity gluconate transporter; Provisional; Region: PRK14984
590409012579	gluconate transporter; Region: gntP; TIGR00791
590409012580	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
590409012581	ATP-binding site [chemical binding]; other site
590409012582	Gluconate-6-phosphate binding site [chemical binding]; other site
590409012583	Shikimate kinase; Region: SKI; pfam01202
590409012584	gluconate operon transcriptional regulator; Provisional; Region: PRK14987
590409012585	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
590409012586	DNA binding site [nucleotide binding]
590409012587	domain linker motif; other site
590409012588	Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575
590409012589	putative ligand binding site [chemical binding]; other site
590409012590	putative dimerization interface [polypeptide binding]; other site
590409012591	Uncharacterized protein conserved in bacteria with the myosin-like domain [Function unknown]; Region: COG4372
590409012592	Pirin-related protein [General function prediction only]; Region: COG1741
590409012593	Pirin; Region: Pirin; pfam02678
590409012594	glycerol-3-phosphate dehydrogenase, anaerobic, C subunit; Region: glycerol3P_GlpC; TIGR03379
590409012595	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
590409012596	Cysteine-rich domain; Region: CCG; pfam02754
590409012597	Cysteine-rich domain; Region: CCG; pfam02754
590409012598	anaerobic glycerol-3-phosphate dehydrogenase subunit B; Validated; Region: PRK05329
590409012599	Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730
590409012600	sn-glycerol-3-phosphate dehydrogenase subunit A; Provisional; Region: glpA; PRK11101
590409012601	hydroxyglutarate oxidase; Provisional; Region: PRK11728
590409012602	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
590409012603	sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273
590409012604	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
590409012605	putative substrate translocation pore; other site
590409012606	glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143
590409012607	Glycerophosphodiester phosphodiesterase domain of Escherichia coli (GlpQ) and similar proteins; Region: GDPD_EcGlpQ_like; cd08600
590409012608	active site
590409012609	catalytic site [active]
590409012610	metal binding site [ion binding]; metal-binding site
590409012611	putative hydrolase; Provisional; Region: PRK10976
590409012612	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
590409012613	active site
590409012614	motif I; other site
590409012615	motif II; other site
590409012616	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
590409012617	lysophospholipase L2; Provisional; Region: PRK10749
590409012618	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
590409012619	homoserine/homoserine lactone efflux protein; Provisional; Region: rhtB; PRK10520
590409012620	threonine efflux system; Provisional; Region: PRK10229
590409012621	ATP-dependent DNA helicase RecQ; Provisional; Region: PRK11057
590409012622	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
590409012623	ATP binding site [chemical binding]; other site
590409012624	putative Mg++ binding site [ion binding]; other site
590409012625	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
590409012626	nucleotide binding region [chemical binding]; other site
590409012627	ATP-binding site [chemical binding]; other site
590409012628	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
590409012629	Helicase and RNase D C-terminal; Region: HRDC; smart00341
590409012630	The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541
590409012631	dimerization interface [polypeptide binding]; other site
590409012632	substrate binding site [chemical binding]; other site
590409012633	active site
590409012634	calcium binding site [ion binding]; other site
590409012635	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
590409012636	CoenzymeA binding site [chemical binding]; other site
590409012637	subunit interaction site [polypeptide binding]; other site
590409012638	PHB binding site; other site
590409012639	putative chloramphenical resistance permease RarD; Provisional; Region: PRK15430
590409012640	Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180
590409012641	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
590409012642	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
590409012643	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
590409012644	Escherichia coli Mg2+ transporter CorA_like subgroup; Region: EcCorA-like_1; cd12835
590409012645	Cl binding site [ion binding]; other site
590409012646	oligomer interface [polypeptide binding]; other site
590409012647	DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773
590409012648	Part of AAA domain; Region: AAA_19; pfam13245
590409012649	Family description; Region: UvrD_C_2; pfam13538
590409012650	flavin mononucleotide phosphatase; Provisional; Region: PRK10748
590409012651	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
590409012652	motif II; other site
590409012653	Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973
590409012654	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
590409012655	active site
590409012656	DNA binding site [nucleotide binding]
590409012657	Int/Topo IB signature motif; other site
590409012658	hypothetical protein; Provisional; Region: PRK10963
590409012659	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
590409012660	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
590409012661	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
590409012662	Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cd00503
590409012663	putative iron binding site [ion binding]; other site
590409012664	adenylate cyclase; Provisional; Region: cyaA; PRK09450
590409012665	Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633
590409012666	Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295
590409012667	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
590409012668	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494
590409012669	domain interfaces; other site
590409012670	active site
590409012671	uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928
590409012672	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
590409012673	active site
590409012674	putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920
590409012675	Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemX; COG2959
590409012676	putative protoheme IX biogenesis protein; Provisional; Region: PRK10747
590409012677	HemY protein N-terminus; Region: HemY_N; pfam07219
590409012678	M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669
590409012679	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
590409012680	metal binding site [ion binding]; metal-binding site
590409012681	dimer interface [polypeptide binding]; other site
590409012682	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
590409012683	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
590409012684	Walker A/P-loop; other site
590409012685	ATP binding site [chemical binding]; other site
590409012686	Q-loop/lid; other site
590409012687	ABC transporter signature motif; other site
590409012688	Walker B; other site
590409012689	D-loop; other site
590409012690	H-loop/switch region; other site
590409012691	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
590409012692	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
590409012693	dimer interface [polypeptide binding]; other site
590409012694	conserved gate region; other site
590409012695	putative PBP binding loops; other site
590409012696	ABC-ATPase subunit interface; other site
590409012697	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
590409012698	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
590409012699	substrate binding pocket [chemical binding]; other site
590409012700	membrane-bound complex binding site; other site
590409012701	hinge residues; other site
590409012702	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
590409012703	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
590409012704	Coenzyme A binding pocket [chemical binding]; other site
590409012705	prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597
590409012706	Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015
590409012707	tetramer interface [polypeptide binding]; other site
590409012708	active site
590409012709	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
590409012710	Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371
590409012711	Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172
590409012712	putative active site [active]
590409012713	metal binding site [ion binding]; metal-binding site
590409012714	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
590409012715	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
590409012716	substrate binding pocket [chemical binding]; other site
590409012717	membrane-bound complex binding site; other site
590409012718	hinge residues; other site
590409012719	putative transport protein YifK; Provisional; Region: PRK10746
590409012720	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
590409012721	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
590409012722	putative common antigen polymerase; Provisional; Region: PRK02975
590409012723	4-alpha-L-fucosyltransferase glycosyl transferase group 56; Region: Glyco_transf_56; cl07929
590409012724	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_10; cd13125
590409012725	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
590409012726	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
590409012727	inhibitor-cofactor binding pocket; inhibition site
590409012728	pyridoxal 5'-phosphate binding site [chemical binding]; other site
590409012729	catalytic residue [active]
590409012730	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
590409012731	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
590409012732	Coenzyme A binding pocket [chemical binding]; other site
590409012733	UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064
590409012734	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
590409012735	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
590409012736	UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381
590409012737	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
590409012738	active site
590409012739	homodimer interface [polypeptide binding]; other site
590409012740	lipopolysaccharide biosynthesis protein WzzE; Provisional; Region: PRK11638
590409012741	Chain length determinant protein; Region: Wzz; cl15801
590409012742	undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase; Provisional; Region: PRK15119
590409012743	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
590409012744	Mg++ binding site [ion binding]; other site
590409012745	putative catalytic motif [active]
590409012746	substrate binding site [chemical binding]; other site
590409012747	transcription termination factor Rho; Provisional; Region: rho; PRK09376
590409012748	Rho termination factor, N-terminal domain; Region: Rho_N; smart00959
590409012749	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
590409012750	RNA binding site [nucleotide binding]; other site
590409012751	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
590409012752	multimer interface [polypeptide binding]; other site
590409012753	Walker A motif; other site
590409012754	ATP binding site [chemical binding]; other site
590409012755	Walker B motif; other site
590409012756	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
590409012757	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
590409012758	catalytic residues [active]
590409012759	ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837
590409012760	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
590409012761	ATP binding site [chemical binding]; other site
590409012762	Mg++ binding site [ion binding]; other site
590409012763	motif III; other site
590409012764	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
590409012765	nucleotide binding region [chemical binding]; other site
590409012766	ATP-binding site [chemical binding]; other site
590409012767	guanosine pentaphosphate phosphohydrolase; Provisional; Region: PRK11031
590409012768	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
590409012769	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
590409012770	Interdomain contacts; other site
590409012771	Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708
590409012772	ATP-dependent DNA helicase Rep; Provisional; Region: PRK10919
590409012773	Part of AAA domain; Region: AAA_19; pfam13245
590409012774	Family description; Region: UvrD_C_2; pfam13538
590409012775	PPIC-type PPIASE domain; Region: Rotamase_2; cl08278
590409012776	Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760
590409012777	trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: putA; PRK11809
590409012778	Predicted transcriptional regulator [Transcription]; Region: COG3905
590409012779	Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506
590409012780	Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125
590409012781	Glutamate binding site [chemical binding]; other site
590409012782	NAD binding site [chemical binding]; other site
590409012783	catalytic residues [active]
590409012784	Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475
590409012785	Na binding site [ion binding]; other site
590409012786	ketol-acid reductoisomerase; Validated; Region: PRK05225
590409012787	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
590409012788	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
590409012789	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
590409012790	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
590409012791	DNA-binding transcriptional regulator IlvY; Provisional; Region: PRK11716
590409012792	The C-terminal substrate binding of LysR-type transcriptional regulator IlvY, which activates the expression of ilvC gene that encoding acetohydroxy acid isomeroreductase for the biosynthesis of branched amino acids; contains the type 2 periplasmic bindin; Region: PBP2_IlvY; cd08430
590409012793	putative dimerization interface [polypeptide binding]; other site
590409012794	Protein of unknown function (DUF1311); Region: DUF1311; pfam07007
590409012795	Conserved hypothetical protein (DUF2461); Region: DUF2461; pfam09365
590409012796	threonine dehydratase; Reviewed; Region: PRK09224
590409012797	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
590409012798	tetramer interface [polypeptide binding]; other site
590409012799	pyridoxal 5'-phosphate binding site [chemical binding]; other site
590409012800	catalytic residue [active]
590409012801	First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906
590409012802	putative Ile/Val binding site [chemical binding]; other site
590409012803	Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907
590409012804	putative Ile/Val binding site [chemical binding]; other site
590409012805	dihydroxy-acid dehydratase; Provisional; Region: PRK12448
590409012806	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
590409012807	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
590409012808	homodimer interface [polypeptide binding]; other site
590409012809	substrate-cofactor binding pocket; other site
590409012810	catalytic residue [active]
590409012811	acetolactate synthase 2 regulatory subunit; Provisional; Region: ilvM; PRK11152
590409012812	acetolactate synthase 2 catalytic subunit; Reviewed; Region: PRK08978
590409012813	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
590409012814	PYR/PP interface [polypeptide binding]; other site
590409012815	dimer interface [polypeptide binding]; other site
590409012816	TPP binding site [chemical binding]; other site
590409012817	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
590409012818	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
590409012819	TPP-binding site [chemical binding]; other site
590409012820	dimer interface [polypeptide binding]; other site
590409012821	putative sialic acid transporter; Region: 2A0112; TIGR00891
590409012822	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
590409012823	putative substrate translocation pore; other site
590409012824	putative ATP-dependent protease; Provisional; Region: PRK09862
590409012825	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
590409012826	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
590409012827	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
590409012828	hypothetical protein; Provisional; Region: PRK11027
590409012829	transcriptional regulator HdfR; Provisional; Region: PRK03601
590409012830	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
590409012831	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
590409012832	dimerization interface [polypeptide binding]; other site
590409012833	glutamate racemase; Provisional; Region: PRK00865
590409012834	vitamin B12/cobalamin outer membrane transporter; Provisional; Region: btuB; PRK10641
590409012835	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
590409012836	N-terminal plug; other site
590409012837	ligand-binding site [chemical binding]; other site
590409012838	tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031
590409012839	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
590409012840	S-adenosylmethionine binding site [chemical binding]; other site
590409012841	hypothetical protein; Provisional; Region: PRK11056
590409012842	DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202
590409012843	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
590409012844	soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249
590409012845	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
590409012846	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
590409012847	DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151
590409012848	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
590409012849	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
590409012850	dimerization interface [polypeptide binding]; other site
590409012851	Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013
590409012852	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
590409012853	catalytic triad [active]
590409012854	dimer interface [polypeptide binding]; other site
590409012855	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
590409012856	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
590409012857	FAD binding site [chemical binding]; other site
590409012858	bifunctional aspartate kinase II/homoserine dehydrogenase II; Provisional; Region: metL; PRK09466
590409012859	AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257
590409012860	putative catalytic residues [active]
590409012861	putative nucleotide binding site [chemical binding]; other site
590409012862	putative aspartate binding site [chemical binding]; other site
590409012863	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
590409012864	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
590409012865	cystathionine gamma-synthase; Provisional; Region: PRK08045
590409012866	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
590409012867	homodimer interface [polypeptide binding]; other site
590409012868	substrate-cofactor binding pocket; other site
590409012869	pyridoxal 5'-phosphate binding site [chemical binding]; other site
590409012870	catalytic residue [active]
590409012871	Met Repressor, MetJ.  MetJ is a bacterial regulatory protein that uses S-adenosylmethionine (SAM) as a corepressor to regulate the production of Methionine. MetJ binds arrays of two to five adjacent copies of an eight base-pair 'metbox'...; Region: Met_repressor_MetJ; cd00490
590409012872	dimerization interface [polypeptide binding]; other site
590409012873	DNA binding site [nucleotide binding]
590409012874	corepressor binding sites; other site
590409012875	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019
590409012876	primosome assembly protein PriA; Validated; Region: PRK05580
590409012877	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
590409012878	ATP binding site [chemical binding]; other site
590409012879	putative Mg++ binding site [ion binding]; other site
590409012880	helicase superfamily c-terminal domain; Region: HELICc; smart00490
590409012881	ATP-binding site [chemical binding]; other site
590409012882	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
590409012883	DNA binding site [nucleotide binding]
590409012884	DNA-binding transcriptional regulator CytR; Provisional; Region: PRK11041
590409012885	domain linker motif; other site
590409012886	Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284
590409012887	dimerization interface [polypeptide binding]; other site
590409012888	ligand binding site [chemical binding]; other site
590409012889	essential cell division protein FtsN; Provisional; Region: PRK10927
590409012890	cell division protein FtsN; Provisional; Region: PRK12757
590409012891	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
590409012892	active site
590409012893	HslU subunit interaction site [polypeptide binding]; other site
590409012894	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
590409012895	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
590409012896	Walker A motif; other site
590409012897	ATP binding site [chemical binding]; other site
590409012898	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
590409012899	Walker B motif; other site
590409012900	arginine finger; other site
590409012901	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
590409012902	1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080
590409012903	UbiA prenyltransferase family; Region: UbiA; pfam01040
590409012904	ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372
590409012905	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3074
590409012906	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
590409012907	amphipathic channel; other site
590409012908	Asn-Pro-Ala signature motifs; other site
590409012909	glycerol kinase; Provisional; Region: glpK; PRK00047
590409012910	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
590409012911	N- and C-terminal domain interface [polypeptide binding]; other site
590409012912	active site
590409012913	MgATP binding site [chemical binding]; other site
590409012914	catalytic site [active]
590409012915	metal binding site [ion binding]; metal-binding site
590409012916	glycerol binding site [chemical binding]; other site
590409012917	homotetramer interface [polypeptide binding]; other site
590409012918	homodimer interface [polypeptide binding]; other site
590409012919	FBP binding site [chemical binding]; other site
590409012920	protein IIAGlc interface [polypeptide binding]; other site
590409012921	Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516
590409012922	Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320
590409012923	putative active site [active]
590409012924	ferredoxin-NADP reductase; Provisional; Region: PRK10926
590409012925	Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195
590409012926	FAD binding pocket [chemical binding]; other site
590409012927	FAD binding motif [chemical binding]; other site
590409012928	phosphate binding motif [ion binding]; other site
590409012929	beta-alpha-beta structure motif; other site
590409012930	NAD binding pocket [chemical binding]; other site
590409012931	Predicted membrane protein [Function unknown]; Region: COG3152
590409012932	Protein of unknown function (DUF1454); Region: DUF1454; pfam07305
590409012933	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
590409012934	triosephosphate isomerase; Provisional; Region: PRK14567
590409012935	substrate binding site [chemical binding]; other site
590409012936	dimer interface [polypeptide binding]; other site
590409012937	catalytic triad [active]
590409012938	alkaline phosphatase; Provisional; Region: PRK10518
590409012939	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016
590409012940	dimer interface [polypeptide binding]; other site
590409012941	active site
590409012942	RNA 2'-phosphotransferase, Tpt1 / KptA family; Region: PTS_2-RNA; pfam01885
590409012943	RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859
590409012944	Toxin SymE, type I toxin-antitoxin system; Region: SymE_toxin; pfam08845
590409012945	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
590409012946	non-specific DNA binding site [nucleotide binding]; other site
590409012947	salt bridge; other site
590409012948	sequence-specific DNA binding site [nucleotide binding]; other site
590409012949	Winged helix-turn-helix DNA-binding; Region: HTH_35; pfam13693
590409012950	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
590409012951	non-specific DNA binding site [nucleotide binding]; other site
590409012952	salt bridge; other site
590409012953	sequence-specific DNA binding site [nucleotide binding]; other site
590409012954	dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749
590409012955	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
590409012956	haemagglutination activity domain; Region: Haemagg_act; pfam05860
590409012957	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
590409012958	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
590409012959	Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332
590409012960	RTX toxin acyltransferase family; Region: HlyC; pfam02794
590409012961	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
590409012962	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
590409012963	Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865
590409012964	agmatine deiminase; Provisional; Region: PRK13551
590409012965	agmatine deiminase; Region: agmatine_aguA; TIGR03380
590409012966	N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573
590409012967	N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381
590409012968	putative active site; other site
590409012969	catalytic triad [active]
590409012970	putative dimer interface [polypeptide binding]; other site
590409012971	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763
590409012972	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
590409012973	active site
590409012974	ADP/pyrophosphate binding site [chemical binding]; other site
590409012975	dimerization interface [polypeptide binding]; other site
590409012976	allosteric effector site; other site
590409012977	fructose-1,6-bisphosphate binding site; other site
590409012978	ferrous iron efflux protein F; Reviewed; Region: fieF; PRK09509
590409012979	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
590409012980	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
590409012981	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
590409012982	non-specific DNA binding site [nucleotide binding]; other site
590409012983	salt bridge; other site
590409012984	sequence-specific DNA binding site [nucleotide binding]; other site
590409012985	2TM domain; Region: 2TM; pfam13239
590409012986	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily requires a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_26; cd04685
590409012987	nudix motif; other site
590409012988	Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413
590409012989	Phage tail-collar fibre protein; Region: DUF3751; pfam12571
590409012990	Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413
590409012991	Phage tail-collar fibre protein; Region: DUF3751; pfam12571
590409012992	Phage Tail Collar Domain; Region: Collar; pfam07484
590409012993	Phage tail-collar fibre protein; Region: DUF3751; pfam12571
590409012994	Phage Tail Collar Domain; Region: Collar; pfam07484
590409012995	Phage tail-collar fibre protein; Region: DUF3751; pfam12571
590409012996	Phage Tail Collar Domain; Region: Collar; pfam07484
590409012997	Phage tail-collar fibre protein; Region: DUF3751; pfam12571
590409012998	Phage Tail Collar Domain; Region: Collar; pfam07484
590409012999	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916
590409013000	dimer interface [polypeptide binding]; other site
590409013001	DNA-binding transcriptional regulator CpxR; Provisional; Region: PRK10955
590409013002	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
590409013003	active site
590409013004	phosphorylation site [posttranslational modification]
590409013005	intermolecular recognition site; other site
590409013006	dimerization interface [polypeptide binding]; other site
590409013007	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
590409013008	DNA binding site [nucleotide binding]
590409013009	two-component sensor protein; Provisional; Region: cpxA; PRK09470
590409013010	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
590409013011	dimerization interface [polypeptide binding]; other site
590409013012	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
590409013013	dimer interface [polypeptide binding]; other site
590409013014	phosphorylation site [posttranslational modification]
590409013015	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
590409013016	ATP binding site [chemical binding]; other site
590409013017	Mg2+ binding site [ion binding]; other site
590409013018	G-X-G motif; other site
590409013019	Protein of unknown function (DUF3142); Region: DUF3142; pfam11340
590409013020	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
590409013021	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
590409013022	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
590409013023	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
590409013024	Predicted permeases [General function prediction only]; Region: COG0679
590409013025	cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454
590409013026	Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562
590409013027	putative active site [active]
590409013028	catalytic site [active]
590409013029	putative metal binding site [ion binding]; other site
590409013030	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
590409013031	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
590409013032	Walker A/P-loop; other site
590409013033	ATP binding site [chemical binding]; other site
590409013034	Q-loop/lid; other site
590409013035	ABC transporter signature motif; other site
590409013036	Walker B; other site
590409013037	D-loop; other site
590409013038	H-loop/switch region; other site
590409013039	TOBE domain; Region: TOBE_2; pfam08402
590409013040	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
590409013041	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
590409013042	dimer interface [polypeptide binding]; other site
590409013043	conserved gate region; other site
590409013044	putative PBP binding loops; other site
590409013045	ABC-ATPase subunit interface; other site
590409013046	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
590409013047	dimer interface [polypeptide binding]; other site
590409013048	conserved gate region; other site
590409013049	putative PBP binding loops; other site
590409013050	ABC-ATPase subunit interface; other site
590409013051	glycerol-3-phosphate transporter periplasmic binding protein; Provisional; Region: PRK10974
590409013052	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
590409013053	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
590409013054	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
590409013055	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
590409013056	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
590409013057	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
590409013058	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395
590409013059	putative aldolase; Validated; Region: PRK08130
590409013060	active site
590409013061	intersubunit interface [polypeptide binding]; other site
590409013062	Zn2+ binding site [ion binding]; other site
590409013063	Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622
590409013064	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cl10029
590409013065	putative transporter; Provisional; Region: PRK09821
590409013066	GntP family permease; Region: GntP_permease; pfam02447
590409013067	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
590409013068	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
590409013069	dimer interface [polypeptide binding]; other site
590409013070	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
590409013071	putative CheW interface [polypeptide binding]; other site
590409013072	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
590409013073	HAMP domain; Region: HAMP; pfam00672
590409013074	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
590409013075	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
590409013076	dimer interface [polypeptide binding]; other site
590409013077	putative CheW interface [polypeptide binding]; other site
590409013078	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
590409013079	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
590409013080	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
590409013081	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
590409013082	dimer interface [polypeptide binding]; other site
590409013083	putative CheW interface [polypeptide binding]; other site
590409013084	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
590409013085	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
590409013086	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
590409013087	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
590409013088	dimer interface [polypeptide binding]; other site
590409013089	putative CheW interface [polypeptide binding]; other site
590409013090	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
590409013091	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
590409013092	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
590409013093	dimer interface [polypeptide binding]; other site
590409013094	putative CheW interface [polypeptide binding]; other site
590409013095	DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906
590409013096	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
590409013097	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
590409013098	dimerization interface [polypeptide binding]; other site
590409013099	substrate binding pocket [chemical binding]; other site
590409013100	4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332
590409013101	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
590409013102	putative substrate translocation pore; other site
590409013103	tartrate dehydratase subunit alpha; Validated; Region: PRK08230
590409013104	L(+)-tartrate dehydratase subunit beta; Validated; Region: PRK08228
590409013105	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
590409013106	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
590409013107	Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436
590409013108	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
590409013109	pyridoxal 5'-phosphate binding site [chemical binding]; other site
590409013110	homodimer interface [polypeptide binding]; other site
590409013111	catalytic residue [active]
590409013112	leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livF; PRK11614
590409013113	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
590409013114	Walker A/P-loop; other site
590409013115	ATP binding site [chemical binding]; other site
590409013116	Q-loop/lid; other site
590409013117	ABC transporter signature motif; other site
590409013118	Walker B; other site
590409013119	D-loop; other site
590409013120	H-loop/switch region; other site
590409013121	leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300
590409013122	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
590409013123	Walker A/P-loop; other site
590409013124	ATP binding site [chemical binding]; other site
590409013125	Q-loop/lid; other site
590409013126	ABC transporter signature motif; other site
590409013127	Walker B; other site
590409013128	D-loop; other site
590409013129	H-loop/switch region; other site
590409013130	leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301
590409013131	Domain of unknown function (DUF3382); Region: DUF3382; pfam11862
590409013132	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
590409013133	TM-ABC transporter signature motif; other site
590409013134	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
590409013135	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
590409013136	TM-ABC transporter signature motif; other site
590409013137	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
590409013138	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
590409013139	dimerization interface [polypeptide binding]; other site
590409013140	ligand binding site [chemical binding]; other site
590409013141	Acetyltransferase (GNAT) domain; Region: DUF3749; pfam12568
590409013142	RNA polymerase factor sigma-32; Reviewed; Region: PRK06596
590409013143	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
590409013144	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
590409013145	DNA binding residues [nucleotide binding]
590409013146	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
590409013147	putative protein insertion permease FtsX; Region: ftsX; TIGR00439
590409013148	cell division protein FtsE; Provisional; Region: PRK10908
590409013149	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
590409013150	Walker A/P-loop; other site
590409013151	ATP binding site [chemical binding]; other site
590409013152	Q-loop/lid; other site
590409013153	ABC transporter signature motif; other site
590409013154	Walker B; other site
590409013155	D-loop; other site
590409013156	H-loop/switch region; other site
590409013157	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
590409013158	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
590409013159	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
590409013160	P loop; other site
590409013161	GTP binding site [chemical binding]; other site
590409013162	Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602
590409013163	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
590409013164	S-adenosylmethionine binding site [chemical binding]; other site
590409013165	hypothetical protein; Provisional; Region: PRK10910
590409013166	Domain of unknown function (DUF1820); Region: DUF1820; pfam08850
590409013167	Predicted membrane protein [Function unknown]; Region: COG3714
590409013168	SirA (also known as UvrY,  and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA.  A...; Region: SirA; cd03423
590409013169	CPxP  motif; other site
590409013170	hypothetical protein; Provisional; Region: PRK11212
590409013171	hypothetical protein; Provisional; Region: PRK11615
590409013172	major facilitator superfamily transporter; Provisional; Region: PRK05122
590409013173	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
590409013174	putative substrate translocation pore; other site
590409013175	inner membrane protein YhjD; Region: TIGR00766
590409013176	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491
590409013177	active site 1 [active]
590409013178	dimer interface [polypeptide binding]; other site
590409013179	hexamer interface [polypeptide binding]; other site
590409013180	active site 2 [active]
590409013181	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
590409013182	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
590409013183	substrate binding site [chemical binding]; other site
590409013184	ATP binding site [chemical binding]; other site
590409013185	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
590409013186	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
590409013187	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
590409013188	C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663
590409013189	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
590409013190	Glycosyl hydrolases family 8; Region: Glyco_hydro_8; pfam01270
590409013191	Cellulose synthase subunit D; Region: Cellsynth_D; pfam03500
590409013192	cellulose synthase subunit BcsC; Provisional; Region: PRK11447
590409013193	TPR repeat; Region: TPR_11; pfam13414
590409013194	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
590409013195	TPR motif; other site
590409013196	binding surface
590409013197	Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420
590409013198	cellulose synthase regulator protein; Provisional; Region: PRK11114
590409013199	cellulose synthase catalytic subunit (UDP-forming); Region: CelA; TIGR03030
590409013200	CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421
590409013201	DXD motif; other site
590409013202	PilZ domain; Region: PilZ; pfam07238
590409013203	cellulose synthase operon protein YhjQ; Region: cellulose_yhjQ; TIGR03371
590409013204	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
590409013205	P-loop; other site
590409013206	Magnesium ion binding site [ion binding]; other site
590409013207	O-acetylserine/cysteine export protein; Provisional; Region: PRK11453
590409013208	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
590409013209	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
590409013210	DNA-binding site [nucleotide binding]; DNA binding site
590409013211	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
590409013212	pyridoxal 5'-phosphate binding site [chemical binding]; other site
590409013213	homodimer interface [polypeptide binding]; other site
590409013214	catalytic residue [active]
590409013215	dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308
590409013216	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
590409013217	Walker A/P-loop; other site
590409013218	ATP binding site [chemical binding]; other site
590409013219	Q-loop/lid; other site
590409013220	ABC transporter signature motif; other site
590409013221	Walker B; other site
590409013222	D-loop; other site
590409013223	H-loop/switch region; other site
590409013224	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
590409013225	dipeptide transporter ATP-binding subunit; Provisional; Region: dppD; PRK11022
590409013226	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
590409013227	Walker A/P-loop; other site
590409013228	ATP binding site [chemical binding]; other site
590409013229	Q-loop/lid; other site
590409013230	ABC transporter signature motif; other site
590409013231	Walker B; other site
590409013232	D-loop; other site
590409013233	H-loop/switch region; other site
590409013234	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
590409013235	dipeptide transporter; Provisional; Region: PRK10913
590409013236	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
590409013237	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
590409013238	dimer interface [polypeptide binding]; other site
590409013239	conserved gate region; other site
590409013240	putative PBP binding loops; other site
590409013241	ABC-ATPase subunit interface; other site
590409013242	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
590409013243	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
590409013244	dimer interface [polypeptide binding]; other site
590409013245	conserved gate region; other site
590409013246	putative PBP binding loops; other site
590409013247	ABC-ATPase subunit interface; other site
590409013248	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
590409013249	The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493
590409013250	peptide binding site [polypeptide binding]; other site
590409013251	2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390
590409013252	DNA-binding transcriptional activator DcuR; Provisional; Region: PRK10430
590409013253	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
590409013254	active site
590409013255	phosphorylation site [posttranslational modification]
590409013256	intermolecular recognition site; other site
590409013257	dimerization interface [polypeptide binding]; other site
590409013258	sensory histidine kinase DcuS; Provisional; Region: PRK11086
590409013259	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
590409013260	ATP binding site [chemical binding]; other site
590409013261	Mg2+ binding site [ion binding]; other site
590409013262	G-X-G motif; other site
590409013263	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
590409013264	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625
590409013265	transmembrane helices; other site
590409013266	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
590409013267	Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins.  IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470
590409013268	putative dimer interface [polypeptide binding]; other site
590409013269	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
590409013270	Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins.  IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470
590409013271	putative dimer interface [polypeptide binding]; other site
590409013272	Protein of unknown function (DUF1375); Region: DUF1375; cl11456
590409013273	D-fructose-responsive transcription factor; Region: fruct_sucro_rep; TIGR02417
590409013274	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
590409013275	DNA binding site [nucleotide binding]
590409013276	domain linker motif; other site
590409013277	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
590409013278	shikimate transporter; Provisional; Region: PRK09952
590409013279	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
590409013280	putative substrate translocation pore; other site
590409013281	Predicted neuraminidase (sialidase) [Carbohydrate transport and metabolism]; Region: COG4692
590409013282	BNR repeat-like domain; Region: BNR_2; pfam13088
590409013283	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
590409013284	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
590409013285	inhibitor site; inhibition site
590409013286	active site
590409013287	dimer interface [polypeptide binding]; other site
590409013288	catalytic residue [active]
590409013289	L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947
590409013290	hexamer (dimer of trimers) interface [polypeptide binding]; other site
590409013291	substrate binding site [chemical binding]; other site
590409013292	trimer interface [polypeptide binding]; other site
590409013293	Mn binding site [ion binding]; other site
590409013294	Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_YpCarbK_like; cd07782
590409013295	Ribulose kinase [Energy production and conversion]; Region: AraB; COG1069
590409013296	N- and C-terminal domain interface [polypeptide binding]; other site
590409013297	active site
590409013298	MgATP binding site [chemical binding]; other site
590409013299	catalytic site [active]
590409013300	metal binding site [ion binding]; metal-binding site
590409013301	carbohydrate binding site [chemical binding]; other site
590409013302	putative homodimer interface [polypeptide binding]; other site
590409013303	Protein of unknown function (DUF3748); Region: DUF3748; pfam12566
590409013304	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
590409013305	Protein of unknown function (DUF1471); Region: DUF1471; cl11507
590409013306	Transcriptional regulators [Transcription]; Region: FadR; COG2186
590409013307	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
590409013308	DNA-binding site [nucleotide binding]; DNA binding site
590409013309	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
590409013310	mannonate dehydratase; Provisional; Region: PRK03906
590409013311	mannonate dehydratase; Region: uxuA; TIGR00695
590409013312	sugar phosphate phosphatase; Provisional; Region: PRK10513
590409013313	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
590409013314	active site
590409013315	motif I; other site
590409013316	motif II; other site
590409013317	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
590409013318	Cache domain; Region: Cache_1; pfam02743
590409013319	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
590409013320	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
590409013321	dimer interface [polypeptide binding]; other site
590409013322	putative CheW interface [polypeptide binding]; other site
590409013323	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
590409013324	Ligand Binding Site [chemical binding]; other site
590409013325	universal stress protein UspB; Provisional; Region: PRK04960
590409013326	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
590409013327	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
590409013328	Predicted flavoproteins [General function prediction only]; Region: COG2081
590409013329	Protein of unknown function (DUF1471); Region: DUF1471; pfam07338
590409013330	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
590409013331	putative catalytic site [active]
590409013332	putative metal binding site [ion binding]; other site
590409013333	putative phosphate binding site [ion binding]; other site
590409013334	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
590409013335	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
590409013336	Walker A/P-loop; other site
590409013337	ATP binding site [chemical binding]; other site
590409013338	Q-loop/lid; other site
590409013339	ABC transporter signature motif; other site
590409013340	Walker B; other site
590409013341	D-loop; other site
590409013342	H-loop/switch region; other site
590409013343	TOBE domain; Region: TOBE_2; pfam08402
590409013344	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
590409013345	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
590409013346	dimer interface [polypeptide binding]; other site
590409013347	conserved gate region; other site
590409013348	putative PBP binding loops; other site
590409013349	ABC-ATPase subunit interface; other site
590409013350	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
590409013351	dimer interface [polypeptide binding]; other site
590409013352	conserved gate region; other site
590409013353	putative PBP binding loops; other site
590409013354	ABC-ATPase subunit interface; other site
590409013355	Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182
590409013356	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
590409013357	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
590409013358	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
590409013359	nucleotide binding site [chemical binding]; other site
590409013360	Protein of unknown function (DUF1471); Region: DUF1471; pfam07338
590409013361	D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine  to pyruvate and ammonia.  D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447
590409013362	Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291
590409013363	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
590409013364	catalytic residue [active]
590409013365	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
590409013366	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
590409013367	Coenzyme A binding pocket [chemical binding]; other site
590409013368	glucose-1-phosphatase/inositol phosphatase; Provisional; Region: PRK10173
590409013369	Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061
590409013370	catalytic core [active]
590409013371	Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061
590409013372	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
590409013373	putative substrate translocation pore; other site
590409013374	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
590409013375	Transcriptional regulator [Transcription]; Region: LysR; COG0583
590409013376	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
590409013377	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
590409013378	putative effector binding pocket; other site
590409013379	dimerization interface [polypeptide binding]; other site
590409013380	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
590409013381	Major Facilitator Superfamily; Region: MFS_1; pfam07690
590409013382	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
590409013383	Major Facilitator Superfamily; Region: MFS_1; pfam07690
590409013384	Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl17299
590409013385	short chain dehydrogenase; Provisional; Region: PRK09072
590409013386	classical (c) SDRs; Region: SDR_c; cd05233
590409013387	NAD(P) binding site [chemical binding]; other site
590409013388	active site
590409013389	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
590409013390	TPR motif; other site
590409013391	TPR repeat; Region: TPR_11; pfam13414
590409013392	binding surface
590409013393	NAD-dependent DNA ligase LigB; Reviewed; Region: ligB; PRK08097
590409013394	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295
590409013395	nucleotide binding pocket [chemical binding]; other site
590409013396	K-X-D-G motif; other site
590409013397	catalytic site [active]
590409013398	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
590409013399	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
590409013400	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
590409013401	catalytic site [active]
590409013402	G-X2-G-X-G-K; other site
590409013403	DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690
590409013404	bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092
590409013405	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
590409013406	Zn2+ binding site [ion binding]; other site
590409013407	Mg2+ binding site [ion binding]; other site
590409013408	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
590409013409	synthetase active site [active]
590409013410	NTP binding site [chemical binding]; other site
590409013411	metal binding site [ion binding]; metal-binding site
590409013412	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
590409013413	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
590409013414	tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081
590409013415	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
590409013416	SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105
590409013417	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
590409013418	Y-family of DNA polymerases; Region: PolY; cl12025
590409013419	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
590409013420	generic binding surface II; other site
590409013421	ssDNA binding site; other site
590409013422	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
590409013423	ATP binding site [chemical binding]; other site
590409013424	putative Mg++ binding site [ion binding]; other site
590409013425	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
590409013426	nucleotide binding region [chemical binding]; other site
590409013427	ATP-binding site [chemical binding]; other site
590409013428	Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233
590409013429	AsmA family; Region: AsmA; pfam05170
590409013430	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
590409013431	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
590409013432	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
590409013433	Coenzyme A binding pocket [chemical binding]; other site
590409013434	Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; pfam09500
590409013435	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
590409013436	putative active site [active]
590409013437	dimerization interface [polypeptide binding]; other site
590409013438	putative tRNAtyr binding site [nucleotide binding]; other site
590409013439	?-D-glucose-1-phosphatase; Provisional; Region: PRK09456
590409013440	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
590409013441	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
590409013442	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
590409013443	G1 box; other site
590409013444	putative GEF interaction site [polypeptide binding]; other site
590409013445	GTP/Mg2+ binding site [chemical binding]; other site
590409013446	Switch I region; other site
590409013447	G2 box; other site
590409013448	G3 box; other site
590409013449	Switch II region; other site
590409013450	G4 box; other site
590409013451	G5 box; other site
590409013452	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
590409013453	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
590409013454	glutamine synthetase; Provisional; Region: glnA; PRK09469
590409013455	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
590409013456	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
590409013457	nitrogen regulation protein NR(II); Provisional; Region: glnL; PRK11073
590409013458	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
590409013459	dimer interface [polypeptide binding]; other site
590409013460	phosphorylation site [posttranslational modification]
590409013461	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
590409013462	ATP binding site [chemical binding]; other site
590409013463	Mg2+ binding site [ion binding]; other site
590409013464	G-X-G motif; other site
590409013465	nitrogen regulation protein NR(I); Provisional; Region: glnG; PRK10923
590409013466	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
590409013467	active site
590409013468	phosphorylation site [posttranslational modification]
590409013469	intermolecular recognition site; other site
590409013470	dimerization interface [polypeptide binding]; other site
590409013471	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
590409013472	Walker A motif; other site
590409013473	ATP binding site [chemical binding]; other site
590409013474	Walker B motif; other site
590409013475	arginine finger; other site
590409013476	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
590409013477	coproporphyrinogen III oxidase; Provisional; Region: PRK09249
590409013478	HemN C-terminal domain; Region: HemN_C; pfam06969
590409013479	Der GTPase activator; Provisional; Region: PRK05244
590409013480	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
590409013481	G1 box; other site
590409013482	GTP/Mg2+ binding site [chemical binding]; other site
590409013483	Switch I region; other site
590409013484	G2 box; other site
590409013485	G3 box; other site
590409013486	Switch II region; other site
590409013487	G4 box; other site
590409013488	G5 box; other site
590409013489	DNA polymerase I; Provisional; Region: PRK05755
590409013490	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
590409013491	active site
590409013492	metal binding site 1 [ion binding]; metal-binding site
590409013493	putative 5' ssDNA interaction site; other site
590409013494	metal binding site 3; metal-binding site
590409013495	metal binding site 2 [ion binding]; metal-binding site
590409013496	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
590409013497	putative DNA binding site [nucleotide binding]; other site
590409013498	putative metal binding site [ion binding]; other site
590409013499	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
590409013500	active site
590409013501	catalytic site [active]
590409013502	substrate binding site [chemical binding]; other site
590409013503	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
590409013504	active site
590409013505	DNA binding site [nucleotide binding]
590409013506	catalytic site [active]
590409013507	DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019
590409013508	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
590409013509	catalytic residues [active]
590409013510	hinge region; other site
590409013511	alpha helical domain; other site
590409013512	Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334
590409013513	serine/threonine protein kinase; Provisional; Region: PRK11768
590409013514	Protein of unknown function (DUF1040); Region: DUF1040; pfam06288
590409013515	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
590409013516	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
590409013517	GTP binding site; other site
590409013518	Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116
590409013519	Walker A motif; other site
590409013520	transcriptional repressor RbsR; Provisional; Region: PRK10423
590409013521	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
590409013522	DNA binding site [nucleotide binding]
590409013523	domain linker motif; other site
590409013524	Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275
590409013525	dimerization interface [polypeptide binding]; other site
590409013526	ligand binding site [chemical binding]; other site
590409013527	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
590409013528	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
590409013529	substrate binding site [chemical binding]; other site
590409013530	dimer interface [polypeptide binding]; other site
590409013531	ATP binding site [chemical binding]; other site
590409013532	D-ribose transporter subunit RbsB; Provisional; Region: PRK10653
590409013533	Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323
590409013534	ligand binding site [chemical binding]; other site
590409013535	dimerization interface [polypeptide binding]; other site
590409013536	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
590409013537	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
590409013538	TM-ABC transporter signature motif; other site
590409013539	D-ribose transporter ATP binding protein; Provisional; Region: PRK10762
590409013540	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
590409013541	Walker A/P-loop; other site
590409013542	ATP binding site [chemical binding]; other site
590409013543	Q-loop/lid; other site
590409013544	ABC transporter signature motif; other site
590409013545	Walker B; other site
590409013546	D-loop; other site
590409013547	H-loop/switch region; other site
590409013548	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
590409013549	D-ribose pyranase; Provisional; Region: PRK11797
590409013550	potassium transport protein Kup; Provisional; Region: trkD; PRK10745
590409013551	potassium uptake protein; Region: kup; TIGR00794
590409013552	regulatory ATPase RavA; Provisional; Region: PRK13531
590409013553	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
590409013554	Walker A motif; other site
590409013555	ATP binding site [chemical binding]; other site
590409013556	Walker B motif; other site
590409013557	arginine finger; other site
590409013558	Protein of unknown function (DUF3763); Region: DUF3763; pfam12592
590409013559	hypothetical protein; Provisional; Region: yieM; PRK10997
590409013560	VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462
590409013561	metal ion-dependent adhesion site (MIDAS); other site
590409013562	DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179
590409013563	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
590409013564	putative DNA binding site [nucleotide binding]; other site
590409013565	putative Zn2+ binding site [ion binding]; other site
590409013566	AsnC family; Region: AsnC_trans_reg; pfam01037
590409013567	FMN-binding protein MioC; Provisional; Region: PRK09004
590409013568	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
590409013569	tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137
590409013570	NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206
590409013571	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
590409013572	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
590409013573	16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107
590409013574	F0F1 ATP synthase subunit I; Validated; Region: PRK08049
590409013575	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
590409013576	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
590409013577	F0F1 ATP synthase subunit C; Validated; Region: PRK06876
590409013578	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
590409013579	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
590409013580	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
590409013581	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
590409013582	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
590409013583	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
590409013584	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
590409013585	beta subunit interaction interface [polypeptide binding]; other site
590409013586	Walker A motif; other site
590409013587	ATP binding site [chemical binding]; other site
590409013588	Walker B motif; other site
590409013589	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
590409013590	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
590409013591	core domain interface [polypeptide binding]; other site
590409013592	delta subunit interface [polypeptide binding]; other site
590409013593	epsilon subunit interface [polypeptide binding]; other site
590409013594	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
590409013595	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
590409013596	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
590409013597	alpha subunit interaction interface [polypeptide binding]; other site
590409013598	Walker A motif; other site
590409013599	ATP binding site [chemical binding]; other site
590409013600	Walker B motif; other site
590409013601	inhibitor binding site; inhibition site
590409013602	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
590409013603	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
590409013604	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
590409013605	gamma subunit interface [polypeptide binding]; other site
590409013606	epsilon subunit interface [polypeptide binding]; other site
590409013607	LBP interface [polypeptide binding]; other site
590409013608	Right handed beta helix region; Region: Beta_helix; pfam13229
590409013609	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK09451
590409013610	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
590409013611	Substrate binding site; other site
590409013612	Mg++ binding site; other site
590409013613	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
590409013614	active site
590409013615	substrate binding site [chemical binding]; other site
590409013616	CoA binding site [chemical binding]; other site
590409013617	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
590409013618	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
590409013619	glutaminase active site [active]
590409013620	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
590409013621	dimer interface [polypeptide binding]; other site
590409013622	active site
590409013623	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
590409013624	dimer interface [polypeptide binding]; other site
590409013625	active site
590409013626	O-methyltransferase; Region: Methyltransf_2; pfam00891
590409013627	Beta-ketoacyl synthase, N-terminal domain; Region: Ketoacyl-synt_2; pfam13723
590409013628	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
590409013629	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
590409013630	putative acyl-acceptor binding pocket; other site
590409013631	Phosphopantetheine attachment site; Region: PP-binding; cl09936
590409013632	acyl carrier protein; Provisional; Region: PRK05350
590409013633	Predicted membrane protein [Function unknown]; Region: COG4648
590409013634	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
590409013635	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
590409013636	acyl-activating enzyme (AAE) consensus motif; other site
590409013637	active site
590409013638	AMP binding site [chemical binding]; other site
590409013639	CoA binding site [chemical binding]; other site
590409013640	FabA/Z, beta-hydroxyacyl-acyl carrier protein (ACP)-dehydratases: One of several distinct enzyme types of the dissociative, type II, fatty acid synthase system (found in bacteria and plants) required to complete successive cycles of fatty acid elongation; Region: FabA_FabZ; cd00493
590409013641	active site 2 [active]
590409013642	dimer interface [polypeptide binding]; other site
590409013643	active site 1 [active]
590409013644	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
590409013645	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
590409013646	Ligand binding site; other site
590409013647	Putative Catalytic site; other site
590409013648	DXD motif; other site
590409013649	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
590409013650	putative acyl-acceptor binding pocket; other site
590409013651	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
590409013652	active site
590409013653	Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548
590409013654	Predicted exporter [General function prediction only]; Region: COG4258
590409013655	Protein of unknown function (DUF3261); Region: DUF3261; pfam11659
590409013656	3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK09185
590409013657	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
590409013658	dimer interface [polypeptide binding]; other site
590409013659	active site
590409013660	Domain of unknown function, appears to be related to a diverse group of beta-hydroxydecanoyl ACP dehydratases (FabA) and beta-hydroxyacyl ACP dehydratases (FabZ). This group appears to lack the conserved active site histidine of FabA and FabZ; Region: FabA_like; cd01289
590409013661	putative active site 1 [active]
590409013662	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
590409013663	3-oxoacyl-(acyl-carrier-protein) reductase, putative; Region: fabG_rel; TIGR01831
590409013664	NAD(P) binding site [chemical binding]; other site
590409013665	active site
590409013666	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK09116
590409013667	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
590409013668	dimer interface [polypeptide binding]; other site
590409013669	active site
590409013670	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
590409013671	GAF domain; Region: GAF; pfam01590
590409013672	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
590409013673	PAS fold; Region: PAS_3; pfam08447
590409013674	putative active site [active]
590409013675	heme pocket [chemical binding]; other site
590409013676	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
590409013677	PAS fold; Region: PAS_3; pfam08447
590409013678	putative active site [active]
590409013679	heme pocket [chemical binding]; other site
590409013680	GAF domain; Region: GAF_2; pfam13185
590409013681	GAF domain; Region: GAF_3; pfam13492
590409013682	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
590409013683	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
590409013684	metal binding site [ion binding]; metal-binding site
590409013685	active site
590409013686	I-site; other site
590409013687	phosphate ABC transporter periplasmic substrate-binding protein PstS; Provisional; Region: PRK10918
590409013688	phosphate transporter permease subunit PstC; Provisional; Region: pstC; PRK11275
590409013689	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
590409013690	dimer interface [polypeptide binding]; other site
590409013691	conserved gate region; other site
590409013692	putative PBP binding loops; other site
590409013693	ABC-ATPase subunit interface; other site
590409013694	phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268
590409013695	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
590409013696	dimer interface [polypeptide binding]; other site
590409013697	conserved gate region; other site
590409013698	putative PBP binding loops; other site
590409013699	ABC-ATPase subunit interface; other site
590409013700	phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744
590409013701	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
590409013702	Walker A/P-loop; other site
590409013703	ATP binding site [chemical binding]; other site
590409013704	Q-loop/lid; other site
590409013705	ABC transporter signature motif; other site
590409013706	Walker B; other site
590409013707	D-loop; other site
590409013708	H-loop/switch region; other site
590409013709	transcriptional regulator PhoU; Provisional; Region: PRK11115
590409013710	PhoU domain; Region: PhoU; pfam01895
590409013711	PhoU domain; Region: PhoU; pfam01895
590409013712	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
590409013713	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
590409013714	substrate binding pocket [chemical binding]; other site
590409013715	membrane-bound complex binding site; other site
590409013716	hinge residues; other site
590409013717	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
590409013718	dimer interface [polypeptide binding]; other site
590409013719	conserved gate region; other site
590409013720	putative PBP binding loops; other site
590409013721	ABC-ATPase subunit interface; other site
590409013722	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
590409013723	dimer interface [polypeptide binding]; other site
590409013724	conserved gate region; other site
590409013725	putative PBP binding loops; other site
590409013726	ABC-ATPase subunit interface; other site
590409013727	6-phosphogluconate phosphatase; Provisional; Region: PRK10563
590409013728	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
590409013729	motif II; other site
590409013730	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
590409013731	Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091
590409013732	Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142
590409013733	4Fe-4S binding domain; Region: Fer4; pfam00037
590409013734	putative oxidoreductase Fe-S binding subunit; Reviewed; Region: PRK12769
590409013735	4Fe-4S binding domain; Region: Fer4; pfam00037
590409013736	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
590409013737	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
590409013738	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
590409013739	inhibitor-cofactor binding pocket; inhibition site
590409013740	pyridoxal 5'-phosphate binding site [chemical binding]; other site
590409013741	catalytic residue [active]
590409013742	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
590409013743	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
590409013744	Ligand binding site; other site
590409013745	Putative Catalytic site; other site
590409013746	DXD motif; other site
590409013747	bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase; Validated; Region: PRK08125
590409013748	Formyltransferase, catalytic core domain; Region: FMT_core; cl00395
590409013749	active site
590409013750	substrate binding site [chemical binding]; other site
590409013751	cosubstrate binding site; other site
590409013752	catalytic site [active]
590409013753	C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702
590409013754	active site
590409013755	hexamer interface [polypeptide binding]; other site
590409013756	Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257
590409013757	NAD binding site [chemical binding]; other site
590409013758	substrate binding site [chemical binding]; other site
590409013759	active site
590409013760	4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD; Provisional; Region: PRK15394
590409013761	Catalytic domain of Escherichia coli 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD and other bacterial homologs; Region: CE4_ArnD; cd10939
590409013762	putative active site [active]
590409013763	putative catalytic site [active]
590409013764	putative Zn binding site [ion binding]; other site
590409013765	4-amino-4-deoxy-L-arabinose transferase; Provisional; Region: arnT; PRK13279
590409013766	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
590409013767	4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051
590409013768	4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971
590409013769	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
590409013770	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
590409013771	Coenzyme A binding pocket [chemical binding]; other site
590409013772	biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244
590409013773	NADH(P)-binding; Region: NAD_binding_10; pfam13460
590409013774	NAD binding site [chemical binding]; other site
590409013775	substrate binding site [chemical binding]; other site
590409013776	putative active site [active]
590409013777	Predicted transcriptional regulators [Transcription]; Region: COG1733
590409013778	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
590409013779	dimerization interface [polypeptide binding]; other site
590409013780	putative DNA binding site [nucleotide binding]; other site
590409013781	putative Zn2+ binding site [ion binding]; other site
590409013782	4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185
590409013783	N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342
590409013784	dimer interface [polypeptide binding]; other site
590409013785	C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250
590409013786	active site
590409013787	Fe binding site [ion binding]; other site
590409013788	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
590409013789	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
590409013790	transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393
590409013791	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137
590409013792	conserved cys residue [active]
590409013793	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
590409013794	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
590409013795	PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995
590409013796	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
590409013797	active site turn [active]
590409013798	phosphorylation site [posttranslational modification]
590409013799	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
590409013800	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
590409013801	HPr interaction site; other site
590409013802	glycerol kinase (GK) interaction site [polypeptide binding]; other site
590409013803	active site
590409013804	phosphorylation site [posttranslational modification]
590409013805	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
590409013806	beta-galactosidase; Region: BGL; TIGR03356
590409013807	transcriptional antiterminator BglG; Provisional; Region: PRK09772
590409013808	CAT RNA binding domain; Region: CAT_RBD; smart01061
590409013809	PRD domain; Region: PRD; pfam00874
590409013810	PRD domain; Region: PRD; pfam00874
590409013811	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
590409013812	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
590409013813	trmE is a tRNA modification GTPase; Region: trmE; cd04164
590409013814	G1 box; other site
590409013815	GTP/Mg2+ binding site [chemical binding]; other site
590409013816	Switch I region; other site
590409013817	G2 box; other site
590409013818	Switch II region; other site
590409013819	G3 box; other site
590409013820	G4 box; other site
590409013821	G5 box; other site
590409013822	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
590409013823	membrane protein insertase; Provisional; Region: PRK01318
590409013824	Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880
590409013825	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
590409013826	hypothetical protein; Validated; Region: PRK00041
590409013827	ribonuclease P; Reviewed; Region: rnpA; PRK01732
590409013828	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399