-- dump date 20140619_065554 -- class Genbank::misc_feature -- table misc_feature_note -- id note 309799000001 phosphoribosylaminoimidazole carboxylase, PurE protein; Region: purE; TIGR01162 309799000002 phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional; Region: PRK13959 309799000003 active site 309799000004 ATP binding site [chemical binding]; other site 309799000005 substrate binding site [chemical binding]; other site 309799000006 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 309799000007 MgtC family; Region: MgtC; pfam02308 309799000008 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 309799000009 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 309799000010 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 309799000011 The substrate binding domain of a cellulose-binding protein from Thermotoga maritima contains the type 2 periplasmic binding fold; Region: PBP2_TmCBP_oligosaccharides_like; cd08509 309799000012 substrate binding site [chemical binding]; other site 309799000013 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 309799000014 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 309799000015 S-adenosylmethionine binding site [chemical binding]; other site 309799000016 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 309799000017 binding surface 309799000018 TPR motif; other site 309799000019 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 309799000020 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 309799000021 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 309799000022 putative metal binding site [ion binding]; other site 309799000023 Glycosyl hydrolase family 26; Region: Glyco_hydro_26; pfam02156 309799000024 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 309799000025 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 309799000026 DNA binding residues [nucleotide binding] 309799000027 putative dimer interface [polypeptide binding]; other site 309799000028 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 309799000029 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 309799000030 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 309799000031 uncharacterized radical SAM protein YgiQ; Region: SAM_YgiQ; TIGR03904 309799000032 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 309799000033 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 309799000034 Uncharacterized conserved protein [Function unknown]; Region: COG0432 309799000035 Transcriptional regulators [Transcription]; Region: PurR; COG1609 309799000036 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 309799000037 DNA binding site [nucleotide binding] 309799000038 domain linker motif; other site 309799000039 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 309799000040 dimerization interface [polypeptide binding]; other site 309799000041 ligand binding site [chemical binding]; other site 309799000042 The substrate binding domain of a cellulose-binding protein from Thermotoga maritima contains the type 2 periplasmic binding fold; Region: PBP2_TmCBP_oligosaccharides_like; cd08509 309799000043 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 309799000044 substrate binding site [chemical binding]; other site 309799000045 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 309799000046 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 309799000047 dimer interface [polypeptide binding]; other site 309799000048 conserved gate region; other site 309799000049 putative PBP binding loops; other site 309799000050 ABC-ATPase subunit interface; other site 309799000051 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 309799000052 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 309799000053 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 309799000054 dimer interface [polypeptide binding]; other site 309799000055 conserved gate region; other site 309799000056 putative PBP binding loops; other site 309799000057 ABC-ATPase subunit interface; other site 309799000058 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 309799000059 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 309799000060 Walker A/P-loop; other site 309799000061 ATP binding site [chemical binding]; other site 309799000062 Q-loop/lid; other site 309799000063 ABC transporter signature motif; other site 309799000064 Walker B; other site 309799000065 D-loop; other site 309799000066 H-loop/switch region; other site 309799000067 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 309799000068 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 309799000069 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 309799000070 Walker A/P-loop; other site 309799000071 ATP binding site [chemical binding]; other site 309799000072 Q-loop/lid; other site 309799000073 ABC transporter signature motif; other site 309799000074 Walker B; other site 309799000075 D-loop; other site 309799000076 H-loop/switch region; other site 309799000077 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 309799000078 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_4; cd08500 309799000079 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 309799000080 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 309799000081 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 309799000082 Walker A/P-loop; other site 309799000083 ATP binding site [chemical binding]; other site 309799000084 Q-loop/lid; other site 309799000085 ABC transporter signature motif; other site 309799000086 Walker B; other site 309799000087 D-loop; other site 309799000088 H-loop/switch region; other site 309799000089 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 309799000090 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 309799000091 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 309799000092 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 309799000093 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 309799000094 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 309799000095 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 309799000096 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 309799000097 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 309799000098 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 309799000099 active site 309799000100 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 309799000101 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 309799000102 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 309799000103 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 309799000104 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 309799000105 active site 309799000106 FMN binding site [chemical binding]; other site 309799000107 substrate binding site [chemical binding]; other site 309799000108 3Fe-4S cluster binding site [ion binding]; other site 309799000109 Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530 309799000110 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 309799000111 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 309799000112 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 309799000113 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 309799000114 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 309799000115 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 309799000116 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 309799000117 dimer interface [polypeptide binding]; other site 309799000118 ABC-ATPase subunit interface; other site 309799000119 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 309799000120 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 309799000121 dimer interface [polypeptide binding]; other site 309799000122 conserved gate region; other site 309799000123 ABC-ATPase subunit interface; other site 309799000124 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 309799000125 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 309799000126 dimerization interface [polypeptide binding]; other site 309799000127 Histidine kinase; Region: His_kinase; pfam06580 309799000128 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 309799000129 ATP binding site [chemical binding]; other site 309799000130 Mg2+ binding site [ion binding]; other site 309799000131 G-X-G motif; other site 309799000132 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 309799000133 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 309799000134 active site 309799000135 phosphorylation site [posttranslational modification] 309799000136 intermolecular recognition site; other site 309799000137 dimerization interface [polypeptide binding]; other site 309799000138 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 309799000139 Alpha-L-fucosidase; Region: Alpha_L_fucos; smart00812 309799000140 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 309799000141 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 309799000142 CrcB-like protein; Region: CRCB; pfam02537 309799000143 putative alpha-glucosidase; Provisional; Region: PRK10658 309799000144 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 309799000145 YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593 309799000146 active site 309799000147 homotrimer interface [polypeptide binding]; other site 309799000148 catalytic site [active] 309799000149 homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site 309799000150 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 309799000151 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 309799000152 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 309799000153 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 309799000154 ligand binding site [chemical binding]; other site 309799000155 metal binding site [ion binding]; metal-binding site 309799000156 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 309799000157 substrate-cofactor binding pocket; other site 309799000158 homodimer interface [polypeptide binding]; other site 309799000159 Aminotransferase class IV; Region: Aminotran_4; pfam01063 309799000160 pyridoxal 5'-phosphate binding site [chemical binding]; other site 309799000161 catalytic residue [active] 309799000162 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 309799000163 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 309799000164 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 309799000165 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 309799000166 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 309799000167 glutamine binding [chemical binding]; other site 309799000168 catalytic triad [active] 309799000169 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 309799000170 hexamer (dimer of trimers) interface [polypeptide binding]; other site 309799000171 substrate binding site [chemical binding]; other site 309799000172 trimer interface [polypeptide binding]; other site 309799000173 Mn binding site [ion binding]; other site 309799000174 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 309799000175 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 309799000176 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 309799000177 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 309799000178 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 309799000179 dimer interface [polypeptide binding]; other site 309799000180 conserved gate region; other site 309799000181 putative PBP binding loops; other site 309799000182 ABC-ATPase subunit interface; other site 309799000183 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 309799000184 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 309799000185 dimer interface [polypeptide binding]; other site 309799000186 conserved gate region; other site 309799000187 putative PBP binding loops; other site 309799000188 ABC-ATPase subunit interface; other site 309799000189 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 309799000190 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 309799000191 substrate binding [chemical binding]; other site 309799000192 active site 309799000193 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 309799000194 Transcriptional regulators [Transcription]; Region: PurR; COG1609 309799000195 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 309799000196 DNA binding site [nucleotide binding] 309799000197 domain linker motif; other site 309799000198 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 309799000199 dimerization interface [polypeptide binding]; other site 309799000200 ligand binding site [chemical binding]; other site 309799000201 sodium binding site [ion binding]; other site 309799000202 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 309799000203 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 309799000204 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 309799000205 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-B; cd09722 309799000206 Domain of unknown function DUF83; Region: Cas_Cas4; pfam01930 309799000207 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 309799000208 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 309799000209 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 309799000210 CRISPR-associated protein Cas5, subtype I-B/TNEAP; Region: cas_Cas5t; TIGR01895 309799000211 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cl12040 309799000212 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I; cl00803 309799000213 CRISPR-associated autoregulator DevR family; Region: cas_MJ0381; TIGR01875 309799000214 CRISPR/Cas system-associated protein Cas8a1; Region: Cas8a1_I-A; cd09665 309799000215 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652 309799000216 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH1; cd08185 309799000217 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 309799000218 putative active site [active] 309799000219 metal binding site [ion binding]; metal-binding site 309799000220 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 309799000221 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 309799000222 active site 309799000223 membrane protein; Provisional; Region: PRK14404 309799000224 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 309799000225 DNA photolyase; Region: DNA_photolyase; pfam00875 309799000226 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 309799000227 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 309799000228 active site 309799000229 membrane protein; Provisional; Region: PRK14404 309799000230 OsmC-like protein; Region: OsmC; pfam02566 309799000231 Lamin Tail Domain; Region: LTD; pfam00932 309799000232 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 309799000233 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 309799000234 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 309799000235 putative RNA binding site [nucleotide binding]; other site 309799000236 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 309799000237 S-adenosylmethionine binding site [chemical binding]; other site 309799000238 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 309799000239 Zn2+ binding site [ion binding]; other site 309799000240 Mg2+ binding site [ion binding]; other site 309799000241 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 309799000242 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 309799000243 Zn2+ binding site [ion binding]; other site 309799000244 Mg2+ binding site [ion binding]; other site 309799000245 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 309799000246 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 309799000247 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 309799000248 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 309799000249 putative FMN binding site [chemical binding]; other site 309799000250 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 309799000251 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 309799000252 active site 309799000253 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 309799000254 active site 309799000255 P-loop; other site 309799000256 phosphorylation site [posttranslational modification] 309799000257 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 309799000258 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 309799000259 dimerization domain swap beta strand [polypeptide binding]; other site 309799000260 regulatory protein interface [polypeptide binding]; other site 309799000261 active site 309799000262 regulatory phosphorylation site [posttranslational modification]; other site 309799000263 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 309799000264 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 309799000265 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 309799000266 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 309799000267 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 309799000268 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 309799000269 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 309799000270 Putative small multi-drug export protein; Region: Sm_multidrug_ex; pfam06695 309799000271 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 309799000272 active site 309799000273 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 309799000274 putative phosphoketolase; Provisional; Region: PRK05261 309799000275 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 309799000276 TPP-binding site; other site 309799000277 XFP C-terminal domain; Region: XFP_C; pfam09363 309799000278 Clostripain family; Region: Peptidase_C11; pfam03415 309799000279 Protein of unknown function (DUF4007); Region: DUF4007; pfam13182 309799000280 Protein of unknown function (DUF4007); Region: DUF4007; pfam13182 309799000281 Protein of unknown function (DUF4007); Region: DUF4007; pfam13182 309799000282 Putative ATP-dependent Lon protease; Region: Lon_2; pfam13337 309799000283 Mrr N-terminal domain; Region: Mrr_N; pfam14338 309799000284 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 309799000285 DNA binding residues [nucleotide binding] 309799000286 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 309799000287 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 309799000288 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 309799000289 Predicted N-acetylglucosamine kinase [Carbohydrate transport and metabolism]; Region: COG2971 309799000290 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 309799000291 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 309799000292 dimer interface [polypeptide binding]; other site 309799000293 active site 309799000294 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 309799000295 dimer interface [polypeptide binding]; other site 309799000296 active site 309799000297 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 309799000298 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 309799000299 putative DNA binding site [nucleotide binding]; other site 309799000300 putative Zn2+ binding site [ion binding]; other site 309799000301 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 309799000302 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 309799000303 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 309799000304 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 309799000305 dimer interface [polypeptide binding]; other site 309799000306 conserved gate region; other site 309799000307 putative PBP binding loops; other site 309799000308 ABC-ATPase subunit interface; other site 309799000309 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 309799000310 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 309799000311 dimer interface [polypeptide binding]; other site 309799000312 conserved gate region; other site 309799000313 ABC-ATPase subunit interface; other site 309799000314 alpha-galactosidase; Provisional; Region: PRK15076 309799000315 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 309799000316 NAD binding site [chemical binding]; other site 309799000317 sugar binding site [chemical binding]; other site 309799000318 divalent metal binding site [ion binding]; other site 309799000319 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 309799000320 dimer interface [polypeptide binding]; other site 309799000321 Tagatose 6 phosphate kinase; Region: Tagatose_6_P_K; cl09211 309799000322 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 309799000323 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 309799000324 substrate binding site [chemical binding]; other site 309799000325 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 309799000326 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 309799000327 NAD(P) binding site [chemical binding]; other site 309799000328 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 309799000329 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 309799000330 Walker A/P-loop; other site 309799000331 ATP binding site [chemical binding]; other site 309799000332 Q-loop/lid; other site 309799000333 ABC transporter signature motif; other site 309799000334 Walker B; other site 309799000335 D-loop; other site 309799000336 H-loop/switch region; other site 309799000337 FtsX-like permease family; Region: FtsX; pfam02687 309799000338 FtsX-like permease family; Region: FtsX; pfam02687 309799000339 Uncharacterized protein domain (DUF2202); Region: DUF2202; pfam09968 309799000340 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB2; cd01048 309799000341 diiron binding motif [ion binding]; other site 309799000342 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 309799000343 Oligomerisation domain; Region: Oligomerisation; pfam02410 309799000344 Transcriptional regulator [Transcription]; Region: LytR; COG1316 309799000345 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 309799000346 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 309799000347 Radical SAM superfamily; Region: Radical_SAM; pfam04055 309799000348 FeS/SAM binding site; other site 309799000349 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 309799000350 putative active site [active] 309799000351 putative metal binding site [ion binding]; other site 309799000352 Transcriptional regulators [Transcription]; Region: PurR; COG1609 309799000353 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 309799000354 DNA binding site [nucleotide binding] 309799000355 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 309799000356 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 309799000357 EamA-like transporter family; Region: EamA; pfam00892 309799000358 cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340 309799000359 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 309799000360 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 309799000361 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 309799000362 Beta galactosidase small chain; Region: Bgal_small_N; smart01038 309799000363 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 309799000364 Trehalase; Region: Trehalase; cl17346 309799000365 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 309799000366 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 309799000367 dimer interface [polypeptide binding]; other site 309799000368 conserved gate region; other site 309799000369 putative PBP binding loops; other site 309799000370 ABC-ATPase subunit interface; other site 309799000371 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 309799000372 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 309799000373 ABC-ATPase subunit interface; other site 309799000374 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 309799000375 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 309799000376 Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379 309799000377 Domain of unknown function (DUF4147); Region: DUF4147; pfam13660 309799000378 MOFRL family; Region: MOFRL; pfam05161 309799000379 Transcriptional regulator PadR-like family; Region: PadR; cl17335 309799000380 Predicted transcriptional regulators [Transcription]; Region: COG1695 309799000381 DNA polymerase III PolC; Validated; Region: polC; PRK00448 309799000382 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 309799000383 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 309799000384 This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851 309799000385 Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237 309799000386 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 309799000387 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 309799000388 substrate binding site; other site 309799000389 tetramer interface; other site 309799000390 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 309799000391 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 309799000392 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 309799000393 NADP binding site [chemical binding]; other site 309799000394 active site 309799000395 putative substrate binding site [chemical binding]; other site 309799000396 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 309799000397 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 309799000398 NAD binding site [chemical binding]; other site 309799000399 substrate binding site [chemical binding]; other site 309799000400 homodimer interface [polypeptide binding]; other site 309799000401 active site 309799000402 Methyltransferase domain; Region: Methyltransf_23; pfam13489 309799000403 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 309799000404 S-adenosylmethionine binding site [chemical binding]; other site 309799000405 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 309799000406 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 309799000407 Probable Catalytic site; other site 309799000408 metal-binding site 309799000409 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 309799000410 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 309799000411 Probable Catalytic site; other site 309799000412 metal-binding site 309799000413 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 309799000414 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 309799000415 WYL domain; Region: WYL; pfam13280 309799000416 CRISPR-associated endoribonuclease Cas6; Region: cas_cas6; TIGR01877 309799000417 CRISPR/Cas system-associated protein Cas8a1; Region: Cas8a1_I-A; cd09672 309799000418 Family of unknown function (DUF694); Region: DUF694; pfam05107 309799000419 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 309799000420 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cl12040 309799000421 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 309799000422 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 309799000423 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 309799000424 Domain of unknown function DUF83; Region: Cas_Cas4; pfam01930 309799000425 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-B; cd09722 309799000426 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 309799000427 Glutamate synthase domain 1 [Amino acid transport and metabolism]; Region: GltB; COG0067 309799000428 Glutamine amidotransferases class-II (Gn-AT)_GlxB-type. GlxB is a glutamine amidotransferase-like protein of unknown function found in bacteria and archaea. GlxB has a structural fold similar to that of other class II glutamine amidotransferases...; Region: GlxB; cd01907 309799000429 putative active site [active] 309799000430 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 309799000431 4Fe-4S binding domain; Region: Fer4; pfam00037 309799000432 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 309799000433 Conserved region in glutamate synthase; Region: Glu_synthase; pfam01645 309799000434 active site 309799000435 FMN binding site [chemical binding]; other site 309799000436 substrate binding site [chemical binding]; other site 309799000437 3Fe-4S cluster binding site [ion binding]; other site 309799000438 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 309799000439 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 309799000440 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 309799000441 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 309799000442 Archaeal-type gltB domain. This domain shares sequence similarity with a region of unknown function found in the large subunit of glutamate synthase, which is encoded by gltB and found in most bacteria and eukaryotes. It is predicted to be homologous to...; Region: arch_gltB; cd00981 309799000443 putative subunit interface; other site 309799000444 NAD synthetase; Provisional; Region: PRK13981 309799000445 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 309799000446 multimer interface [polypeptide binding]; other site 309799000447 active site 309799000448 catalytic triad [active] 309799000449 protein interface 1 [polypeptide binding]; other site 309799000450 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 309799000451 homodimer interface [polypeptide binding]; other site 309799000452 NAD binding pocket [chemical binding]; other site 309799000453 ATP binding pocket [chemical binding]; other site 309799000454 Mg binding site [ion binding]; other site 309799000455 active-site loop [active] 309799000456 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 309799000457 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 309799000458 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 309799000459 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 309799000460 Nitrogen regulatory protein P-II; Region: P-II; smart00938 309799000461 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 309799000462 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 309799000463 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 309799000464 active site 309799000465 FOG: WD40-like repeat [Function unknown]; Region: COG1520 309799000466 Trp docking motif [polypeptide binding]; other site 309799000467 YWTD domain; Region: YWTD; pfam13570 309799000468 FOG: WD40-like repeat [Function unknown]; Region: COG1520 309799000469 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 309799000470 Trp docking motif [polypeptide binding]; other site 309799000471 active site 309799000472 CRISPR/Cas system-associated protein Csx3; Region: Csx3_III-U; cd09681 309799000473 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cd09680 309799000474 CRISPR-associated protein Cas10/Csm1, subtype III-A/MTUBE; Region: cas_TM1811_Csm1; TIGR02578 309799000475 CRISPR/Cas system-associated protein Csm2; Region: Csm2_III-A; cl00622 309799000476 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl17214 309799000477 CRISPR/Cas system-associated RAMP superfamily protein Csm4; Region: Csm4_III-A; cl17438 309799000478 CRISPR/Cas system-associated RAMP superfamily protein Csm5; Region: Csm5_III-A; cl17437 309799000479 CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cl14784 309799000480 CRISPR-associated (Cas) DxTHG family; Region: Cas_DxTHG; pfam09455 309799000481 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 309799000482 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298 309799000483 putative NAD(P) binding site [chemical binding]; other site 309799000484 putative substrate binding site [chemical binding]; other site 309799000485 catalytic Zn binding site [ion binding]; other site 309799000486 structural Zn binding site [ion binding]; other site 309799000487 Uncharacterized conserved protein [Function unknown]; Region: COG2461 309799000488 Family of unknown function (DUF438); Region: DUF438; pfam04282 309799000489 Hemerythrin-like domain; Region: Hr-like; cd12108 309799000490 Fe binding site [ion binding]; other site 309799000491 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 309799000492 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 309799000493 Coenzyme A binding pocket [chemical binding]; other site 309799000494 late competence protein ComER; Validated; Region: PRK07680 309799000495 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 309799000496 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 309799000497 S-adenosylmethionine binding site [chemical binding]; other site 309799000498 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 309799000499 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 309799000500 active site 309799000501 Trp docking motif [polypeptide binding]; other site 309799000502 PQQ-like domain; Region: PQQ_2; pfam13360 309799000503 Transglutaminase-like domain; Region: DUF553; pfam04473 309799000504 O-Antigen ligase; Region: Wzy_C; pfam04932 309799000505 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 309799000506 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 309799000507 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 309799000508 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 309799000509 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 309799000510 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 309799000511 Walker A/P-loop; other site 309799000512 ATP binding site [chemical binding]; other site 309799000513 Q-loop/lid; other site 309799000514 ABC transporter signature motif; other site 309799000515 Walker B; other site 309799000516 D-loop; other site 309799000517 H-loop/switch region; other site 309799000518 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 309799000519 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 309799000520 active site 309799000521 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 309799000522 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 309799000523 putative metal binding site; other site 309799000524 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 309799000525 binding surface 309799000526 TPR motif; other site 309799000527 TPR repeat; Region: TPR_11; pfam13414 309799000528 serine/threonine protein kinase; Provisional; Region: PRK14879 309799000529 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 309799000530 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 309799000531 putative ADP-binding pocket [chemical binding]; other site 309799000532 pantetheine-phosphate adenylyltransferase, bacterial; Region: coaD_prev_kdtB; TIGR01510 309799000533 lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203 309799000534 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 309799000535 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 309799000536 Walker A/P-loop; other site 309799000537 ATP binding site [chemical binding]; other site 309799000538 Q-loop/lid; other site 309799000539 ABC transporter signature motif; other site 309799000540 Walker B; other site 309799000541 D-loop; other site 309799000542 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 309799000543 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 309799000544 Walker A/P-loop; other site 309799000545 ATP binding site [chemical binding]; other site 309799000546 Q-loop/lid; other site 309799000547 ABC transporter signature motif; other site 309799000548 Walker B; other site 309799000549 D-loop; other site 309799000550 H-loop/switch region; other site 309799000551 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 309799000552 SPASM domain peptide maturase, grasp-with-spasm system; Region: SPASM_w_grasp; TIGR04193 309799000553 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 309799000554 Radical SAM superfamily; Region: Radical_SAM; pfam04055 309799000555 radical SAM peptide maturase, GG-Bacteroidales family; Region: GG_samocin_CFB; TIGR04148 309799000556 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 309799000557 FeS/SAM binding site; other site 309799000558 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 309799000559 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 309799000560 Walker A/P-loop; other site 309799000561 ATP binding site [chemical binding]; other site 309799000562 Q-loop/lid; other site 309799000563 ABC transporter signature motif; other site 309799000564 Walker B; other site 309799000565 D-loop; other site 309799000566 H-loop/switch region; other site 309799000567 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 309799000568 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 309799000569 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 309799000570 FeS/SAM binding site; other site 309799000571 HEPN domain; Region: HEPN; cl00824 309799000572 ABC-2 type transporter; Region: ABC2_membrane; cl17235 309799000573 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 309799000574 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 309799000575 ABC transporter signature motif; other site 309799000576 Walker B; other site 309799000577 D-loop; other site 309799000578 SynChlorMet cassette radical SAM/SPASM protein ScmF; Region: SCM_rSAM_ScmF; TIGR04251 309799000579 Uncharacterized conserved protein [Function unknown]; Region: COG2445 309799000580 lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203 309799000581 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 309799000582 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 309799000583 Walker A/P-loop; other site 309799000584 ATP binding site [chemical binding]; other site 309799000585 Q-loop/lid; other site 309799000586 ABC transporter signature motif; other site 309799000587 Walker B; other site 309799000588 D-loop; other site 309799000589 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 309799000590 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 309799000591 Walker A/P-loop; other site 309799000592 ATP binding site [chemical binding]; other site 309799000593 Q-loop/lid; other site 309799000594 ABC transporter signature motif; other site 309799000595 Walker B; other site 309799000596 D-loop; other site 309799000597 H-loop/switch region; other site 309799000598 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 309799000599 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 309799000600 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 309799000601 ABC transporter signature motif; other site 309799000602 Walker B; other site 309799000603 D-loop; other site 309799000604 H-loop/switch region; other site 309799000605 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 309799000606 Walker A/P-loop; other site 309799000607 ATP binding site [chemical binding]; other site 309799000608 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 309799000609 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 309799000610 active site 309799000611 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 309799000612 DNA methylase; Region: N6_N4_Mtase; pfam01555 309799000613 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 309799000614 Major Facilitator Superfamily; Region: MFS_1; pfam07690 309799000615 putative substrate translocation pore; other site 309799000616 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 309799000617 active site 309799000618 NTP binding site [chemical binding]; other site 309799000619 metal binding triad [ion binding]; metal-binding site 309799000620 antibiotic binding site [chemical binding]; other site 309799000621 Protein of unknown function (DUF4038); Region: DUF4038; pfam13204 309799000622 Putative collagen-binding domain of a collagenase; Region: Collagen_bind_2; pfam12904 309799000623 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 309799000624 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 309799000625 putative active site [active] 309799000626 putative dimer interface [polypeptide binding]; other site 309799000627 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 309799000628 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 309799000629 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 309799000630 Pyruvate-formate lyase-activating enzyme [Posttranslational modification, protein turnover, chaperones]; Region: PflA; COG1180 309799000631 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 309799000632 FeS/SAM binding site; other site 309799000633 Predicted peptidase [General function prediction only]; Region: COG4099 309799000634 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 309799000635 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 309799000636 NlpC/P60 family; Region: NLPC_P60; cl17555 309799000637 Right handed beta helix region; Region: Beta_helix; pfam13229 309799000638 Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148 309799000639 Ferredoxin [Energy production and conversion]; Region: COG1146 309799000640 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 309799000641 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 309799000642 dimerization interface [polypeptide binding]; other site 309799000643 putative DNA binding site [nucleotide binding]; other site 309799000644 putative Zn2+ binding site [ion binding]; other site 309799000645 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 309799000646 binding surface 309799000647 Tetratricopeptide repeat; Region: TPR_16; pfam13432 309799000648 TPR motif; other site 309799000649 alpha-galactosidase; Provisional; Region: PRK15076 309799000650 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 309799000651 NAD binding site [chemical binding]; other site 309799000652 sugar binding site [chemical binding]; other site 309799000653 divalent metal binding site [ion binding]; other site 309799000654 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 309799000655 dimer interface [polypeptide binding]; other site 309799000656 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303 309799000657 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 309799000658 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 309799000659 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 309799000660 catalytic triad [active] 309799000661 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 309799000662 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 309799000663 FMN binding site [chemical binding]; other site 309799000664 substrate binding site [chemical binding]; other site 309799000665 putative catalytic residue [active] 309799000666 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 309799000667 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 309799000668 NAD binding site [chemical binding]; other site 309799000669 homotetramer interface [polypeptide binding]; other site 309799000670 homodimer interface [polypeptide binding]; other site 309799000671 substrate binding site [chemical binding]; other site 309799000672 active site 309799000673 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 309799000674 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 309799000675 putative DNA binding site [nucleotide binding]; other site 309799000676 putative Zn2+ binding site [ion binding]; other site 309799000677 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 309799000678 The substrate binding domain of a cellulose-binding protein from Thermotoga maritima contains the type 2 periplasmic binding fold; Region: PBP2_TmCBP_oligosaccharides_like; cd08509 309799000679 substrate binding site [chemical binding]; other site 309799000680 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 309799000681 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 309799000682 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 309799000683 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 309799000684 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 309799000685 dimer interface [polypeptide binding]; other site 309799000686 conserved gate region; other site 309799000687 putative PBP binding loops; other site 309799000688 ABC-ATPase subunit interface; other site 309799000689 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 309799000690 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 309799000691 Walker A/P-loop; other site 309799000692 ATP binding site [chemical binding]; other site 309799000693 Q-loop/lid; other site 309799000694 ABC transporter signature motif; other site 309799000695 Walker B; other site 309799000696 D-loop; other site 309799000697 H-loop/switch region; other site 309799000698 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 309799000699 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 309799000700 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 309799000701 Walker A/P-loop; other site 309799000702 ATP binding site [chemical binding]; other site 309799000703 Q-loop/lid; other site 309799000704 ABC transporter signature motif; other site 309799000705 Walker B; other site 309799000706 D-loop; other site 309799000707 H-loop/switch region; other site 309799000708 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 309799000709 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 309799000710 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 309799000711 Transcriptional regulators [Transcription]; Region: PurR; COG1609 309799000712 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 309799000713 DNA binding site [nucleotide binding] 309799000714 domain linker motif; other site 309799000715 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 309799000716 dimerization interface [polypeptide binding]; other site 309799000717 ligand binding site [chemical binding]; other site 309799000718 L-fucose isomerase; Provisional; Region: fucI; PRK10991 309799000719 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 309799000720 hexamer (dimer of trimers) interface [polypeptide binding]; other site 309799000721 trimer interface [polypeptide binding]; other site 309799000722 substrate binding site [chemical binding]; other site 309799000723 Mn binding site [ion binding]; other site 309799000724 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 309799000725 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 309799000726 Walker A/P-loop; other site 309799000727 ATP binding site [chemical binding]; other site 309799000728 Q-loop/lid; other site 309799000729 ABC transporter signature motif; other site 309799000730 Walker B; other site 309799000731 D-loop; other site 309799000732 H-loop/switch region; other site 309799000733 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 309799000734 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 309799000735 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 309799000736 TM-ABC transporter signature motif; other site 309799000737 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_2; cd06310 309799000738 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 309799000739 putative ligand binding site [chemical binding]; other site 309799000740 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 309799000741 rhamnose ABC transporter, rhamnose-binding protein; Region: RhaS; TIGR02637 309799000742 ligand binding site [chemical binding]; other site 309799000743 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 309799000744 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 309799000745 Walker A/P-loop; other site 309799000746 ATP binding site [chemical binding]; other site 309799000747 Q-loop/lid; other site 309799000748 ABC transporter signature motif; other site 309799000749 Walker B; other site 309799000750 D-loop; other site 309799000751 H-loop/switch region; other site 309799000752 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 309799000753 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 309799000754 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 309799000755 TM-ABC transporter signature motif; other site 309799000756 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 309799000757 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 309799000758 TM-ABC transporter signature motif; other site 309799000759 Anabaena sensory rhodopsin transducer; Region: ASRT; pfam07100 309799000760 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 309799000761 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 309799000762 tetramer interface [polypeptide binding]; other site 309799000763 TPP-binding site [chemical binding]; other site 309799000764 heterodimer interface [polypeptide binding]; other site 309799000765 phosphorylation loop region [posttranslational modification] 309799000766 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 309799000767 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 309799000768 alpha subunit interface [polypeptide binding]; other site 309799000769 TPP binding site [chemical binding]; other site 309799000770 heterodimer interface [polypeptide binding]; other site 309799000771 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 309799000772 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 309799000773 E3 interaction surface; other site 309799000774 lipoyl attachment site [posttranslational modification]; other site 309799000775 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 309799000776 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 309799000777 L-sorbose-1-phosphate reductase; Region: sorbose_phosphate_red; cd08238 309799000778 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 309799000779 putative NAD(P) binding site [chemical binding]; other site 309799000780 catalytic Zn binding site [ion binding]; other site 309799000781 sorbitol-6-phosphate dehydrogenase; Provisional; Region: PRK12384 309799000782 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 309799000783 NAD(P) binding site [chemical binding]; other site 309799000784 active site 309799000785 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 309799000786 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 309799000787 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596 309799000788 intersubunit interface [polypeptide binding]; other site 309799000789 active site 309799000790 Zn2+ binding site [ion binding]; other site 309799000791 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 309799000792 classical (c) SDRs; Region: SDR_c; cd05233 309799000793 NAD(P) binding site [chemical binding]; other site 309799000794 active site 309799000795 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 309799000796 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 309799000797 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 309799000798 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 309799000799 dimer interface [polypeptide binding]; other site 309799000800 conserved gate region; other site 309799000801 putative PBP binding loops; other site 309799000802 ABC-ATPase subunit interface; other site 309799000803 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 309799000804 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 309799000805 dimer interface [polypeptide binding]; other site 309799000806 conserved gate region; other site 309799000807 putative PBP binding loops; other site 309799000808 ABC-ATPase subunit interface; other site 309799000809 L-rhamnose catabolism isomerase, Pseudomonas stutzeri subtype; Region: L_rham_iso_rhiz; TIGR02629 309799000810 L-rhamnose isomerase, Streptomyces subtype; Region: RhaI_grampos; TIGR02635 309799000811 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 309799000812 N- and C-terminal domain interface [polypeptide binding]; other site 309799000813 rhamnulokinase; Region: rhamnulo_kin; TIGR02627 309799000814 active site 309799000815 putative catalytic site [active] 309799000816 metal binding site [ion binding]; metal-binding site 309799000817 ATP binding site [chemical binding]; other site 309799000818 carbohydrate binding site [chemical binding]; other site 309799000819 Superoxide reductase-like (SORL) domain, class II; SORL-domains are present in a family of mononuclear non-heme iron proteins that includes superoxide reductase and desulfoferrodoxin. Superoxide reductase-like proteins scavenge superoxide anion radicals...; Region: SORL_classII; cd03172 309799000820 non-heme iron binding site [ion binding]; other site 309799000821 tetramer interface [polypeptide binding]; other site 309799000822 Amb_all domain; Region: Amb_all; smart00656 309799000823 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 309799000824 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 309799000825 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 309799000826 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 309799000827 dimer interface [polypeptide binding]; other site 309799000828 conserved gate region; other site 309799000829 putative PBP binding loops; other site 309799000830 ABC-ATPase subunit interface; other site 309799000831 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 309799000832 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 309799000833 dimer interface [polypeptide binding]; other site 309799000834 conserved gate region; other site 309799000835 putative PBP binding loops; other site 309799000836 ABC-ATPase subunit interface; other site 309799000837 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 309799000838 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 309799000839 NAD binding site [chemical binding]; other site 309799000840 sugar binding site [chemical binding]; other site 309799000841 divalent metal binding site [ion binding]; other site 309799000842 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 309799000843 dimer interface [polypeptide binding]; other site 309799000844 cyclically-permuted mutarotase family protein; Region: mutarot_permut; TIGR03548 309799000845 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 309799000846 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 309799000847 substrate binding site [chemical binding]; other site 309799000848 ATP binding site [chemical binding]; other site 309799000849 DNA-binding transcriptional repressor AllR; Provisional; Region: PRK10163 309799000850 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 309799000851 putative DNA binding site [nucleotide binding]; other site 309799000852 putative Zn2+ binding site [ion binding]; other site 309799000853 Bacterial transcriptional regulator; Region: IclR; pfam01614 309799000854 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK07565 309799000855 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 309799000856 phosphate binding site [ion binding]; other site 309799000857 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 309799000858 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 309799000859 4Fe-4S binding domain; Region: Fer4; pfam00037 309799000860 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK06263 309799000861 L-aspartate oxidase; Provisional; Region: PRK06175 309799000862 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 309799000863 Hypothetical enzyme TM0436 resembles the zinc-dependent alcohol dehydrogenases (ADH); Region: MDR_TM0436_like; cd08231 309799000864 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 309799000865 catalytic Zn binding site [ion binding]; other site 309799000866 structural Zn binding site [ion binding]; other site 309799000867 tetramer interface [polypeptide binding]; other site 309799000868 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 309799000869 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 309799000870 NAD(P) binding site [chemical binding]; other site 309799000871 active site 309799000872 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 309799000873 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 309799000874 NADP binding site [chemical binding]; other site 309799000875 active site 309799000876 putative substrate binding site [chemical binding]; other site 309799000877 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 309799000878 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 309799000879 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 309799000880 phosphoenolpyruvate carboxylase, archaeal type; Region: PEPCase_arch; TIGR02751 309799000881 Phosphoenolpyruvate carboxylase; Region: PEPcase_2; pfam14010 309799000882 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 309799000883 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 309799000884 ATP binding site [chemical binding]; other site 309799000885 dimerization interface [polypeptide binding]; other site 309799000886 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 309799000887 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 309799000888 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 309799000889 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 309799000890 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 309799000891 AIR carboxylase; Region: AIRC; pfam00731 309799000892 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 309799000893 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 309799000894 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 309799000895 tetramer interface [polypeptide binding]; other site 309799000896 pyridoxal 5'-phosphate binding site [chemical binding]; other site 309799000897 catalytic residue [active] 309799000898 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 309799000899 Catalytic NodB homology domain of Clostridium thermocellum acetylxylan esterase and its bacterial homologs; Region: CE4_CtAXE_like; cd10954 309799000900 NodB motif; other site 309799000901 active site 309799000902 catalytic site [active] 309799000903 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 309799000904 Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273 309799000905 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 309799000906 active site 309799000907 catalytic residues [active] 309799000908 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 309799000909 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 309799000910 Predicted permeases [General function prediction only]; Region: COG0679 309799000911 PAS domain S-box; Region: sensory_box; TIGR00229 309799000912 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 309799000913 putative active site [active] 309799000914 heme pocket [chemical binding]; other site 309799000915 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 309799000916 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 309799000917 metal binding site [ion binding]; metal-binding site 309799000918 active site 309799000919 I-site; other site 309799000920 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 309799000921 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 309799000922 active site 309799000923 catalytic tetrad [active] 309799000924 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 309799000925 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 309799000926 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 309799000927 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 309799000928 active site 309799000929 motif I; other site 309799000930 motif II; other site 309799000931 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 309799000932 beta-galactosidase; Region: BGL; TIGR03356 309799000933 spore photoproduct lyase; Region: photo_TT_lyase; cl15393 309799000934 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 309799000935 Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048 309799000936 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845 309799000937 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 309799000938 YvrJ protein family; Region: YvrJ; pfam12841 309799000939 Peptidase M15; Region: Peptidase_M15_3; cl01194 309799000940 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 309799000941 Protein of unknown function (DUF1659); Region: DUF1659; pfam07872 309799000942 Domain of unknown function (DUF4139); Region: DUF4139; pfam13598 309799000943 4Fe-4S binding domain; Region: Fer4_5; pfam12801 309799000944 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 309799000945 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 309799000946 Beta-Casp domain; Region: Beta-Casp; smart01027 309799000947 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 309799000948 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 309799000949 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 309799000950 Peptidase family M28; Region: Peptidase_M28; pfam04389 309799000951 metal binding site [ion binding]; metal-binding site 309799000952 phosphate transporter permease subunit PstC; Provisional; Region: pstC; PRK11275 309799000953 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 309799000954 dimer interface [polypeptide binding]; other site 309799000955 conserved gate region; other site 309799000956 ABC-ATPase subunit interface; other site 309799000957 phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268 309799000958 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 309799000959 dimer interface [polypeptide binding]; other site 309799000960 conserved gate region; other site 309799000961 putative PBP binding loops; other site 309799000962 ABC-ATPase subunit interface; other site 309799000963 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 309799000964 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 309799000965 Walker A/P-loop; other site 309799000966 ATP binding site [chemical binding]; other site 309799000967 Q-loop/lid; other site 309799000968 ABC transporter signature motif; other site 309799000969 Walker B; other site 309799000970 D-loop; other site 309799000971 H-loop/switch region; other site 309799000972 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 309799000973 PhoU domain; Region: PhoU; pfam01895 309799000974 PhoU domain; Region: PhoU; pfam01895 309799000975 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 309799000976 FOG: WD40-like repeat [Function unknown]; Region: COG1520 309799000977 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07666 309799000978 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 309799000979 NAD(P) binding site [chemical binding]; other site 309799000980 active site 309799000981 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 309799000982 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 309799000983 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 309799000984 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 309799000985 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 309799000986 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 309799000987 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 309799000988 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 309799000989 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 309799000990 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 309799000991 dimer interface [polypeptide binding]; other site 309799000992 conserved gate region; other site 309799000993 putative PBP binding loops; other site 309799000994 ABC-ATPase subunit interface; other site 309799000995 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 309799000996 CPxP motif; other site 309799000997 Sulphur transport; Region: Sulf_transp; pfam04143 309799000998 putative selenium metabolism protein, YedE family; Region: seleno_YedE; TIGR04112 309799000999 Sulphur transport; Region: Sulf_transp; pfam04143 309799001000 DsrE/DsrF-like family; Region: DrsE; cl00672 309799001001 Uncharacterized protein involved in the oxidation of intracellular sulfur [Inorganic ion transport and metabolism]; Region: DsrF; COG2923 309799001002 sulfur relay protein TusB/DsrH; Region: sulf_tusB_dsrH; TIGR03011 309799001003 Predicted oxidoreductase [General function prediction only]; Region: COG3573 309799001004 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 309799001005 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 309799001006 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 309799001007 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 309799001008 Zn2+ binding site [ion binding]; other site 309799001009 Mg2+ binding site [ion binding]; other site 309799001010 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4134 309799001011 hypothetical protein; Provisional; Region: PRK11622 309799001012 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 309799001013 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 309799001014 Walker A/P-loop; other site 309799001015 ATP binding site [chemical binding]; other site 309799001016 Q-loop/lid; other site 309799001017 ABC transporter signature motif; other site 309799001018 Walker B; other site 309799001019 D-loop; other site 309799001020 H-loop/switch region; other site 309799001021 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 309799001022 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 309799001023 dimer interface [polypeptide binding]; other site 309799001024 conserved gate region; other site 309799001025 putative PBP binding loops; other site 309799001026 ABC-ATPase subunit interface; other site 309799001027 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 309799001028 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 309799001029 dimer interface [polypeptide binding]; other site 309799001030 conserved gate region; other site 309799001031 putative PBP binding loops; other site 309799001032 ABC-ATPase subunit interface; other site 309799001033 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527 309799001034 Coenzyme A binding pocket [chemical binding]; other site 309799001035 Sterol carrier protein domain; Region: SCP2_2; pfam13530 309799001036 Glyco_18 domain; Region: Glyco_18; smart00636 309799001037 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 309799001038 active site 309799001039 Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785 309799001040 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 309799001041 active site 309799001042 dimer interface [polypeptide binding]; other site 309799001043 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 309799001044 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 309799001045 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 309799001046 Low molecular weight phosphatase family; Region: LMWPc; cd00115 309799001047 active site 309799001048 Protein of unknown function DUF86; Region: DUF86; cl01031 309799001049 Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018 309799001050 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 309799001051 dimer interface [polypeptide binding]; other site 309799001052 catalytic triad [active] 309799001053 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 309799001054 PAS domain; Region: PAS_9; pfam13426 309799001055 putative active site [active] 309799001056 heme pocket [chemical binding]; other site 309799001057 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 309799001058 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 309799001059 metal binding site [ion binding]; metal-binding site 309799001060 active site 309799001061 I-site; other site 309799001062 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 309799001063 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 309799001064 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 309799001065 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 309799001066 active site 309799001067 catalytic tetrad [active] 309799001068 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 309799001069 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 309799001070 4Fe-4S binding domain; Region: Fer4; pfam00037 309799001071 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 309799001072 Predicted Fe-S protein [General function prediction only]; Region: COG2000 309799001073 Putative Fe-S cluster; Region: FeS; cl17515 309799001074 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 309799001075 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 309799001076 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 309799001077 putative dimer interface [polypeptide binding]; other site 309799001078 [2Fe-2S] cluster binding site [ion binding]; other site 309799001079 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 309799001080 dimer interface [polypeptide binding]; other site 309799001081 [2Fe-2S] cluster binding site [ion binding]; other site 309799001082 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 309799001083 SLBB domain; Region: SLBB; pfam10531 309799001084 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 309799001085 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 309799001086 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 309799001087 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 309799001088 bidirectional hydrogenase complex protein HoxU; Validated; Region: PRK07569 309799001089 catalytic loop [active] 309799001090 iron binding site [ion binding]; other site 309799001091 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 309799001092 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 309799001093 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 309799001094 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 309799001095 Iron hydrogenase small subunit; Region: Fe_hyd_SSU; pfam02256 309799001096 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 309799001097 dimer interface [polypeptide binding]; other site 309799001098 [2Fe-2S] cluster binding site [ion binding]; other site 309799001099 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 309799001100 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 309799001101 CoA binding domain; Region: CoA_binding; pfam02629 309799001102 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 309799001103 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 309799001104 Walker A/P-loop; other site 309799001105 ATP binding site [chemical binding]; other site 309799001106 Q-loop/lid; other site 309799001107 ABC transporter signature motif; other site 309799001108 Walker B; other site 309799001109 D-loop; other site 309799001110 H-loop/switch region; other site 309799001111 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 309799001112 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 309799001113 dimer interface [polypeptide binding]; other site 309799001114 conserved gate region; other site 309799001115 putative PBP binding loops; other site 309799001116 ABC-ATPase subunit interface; other site 309799001117 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 309799001118 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 309799001119 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 309799001120 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 309799001121 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 309799001122 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 309799001123 Walker A/P-loop; other site 309799001124 ATP binding site [chemical binding]; other site 309799001125 Q-loop/lid; other site 309799001126 ABC transporter signature motif; other site 309799001127 Walker B; other site 309799001128 D-loop; other site 309799001129 H-loop/switch region; other site 309799001130 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 309799001131 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 309799001132 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 309799001133 Walker A/P-loop; other site 309799001134 ATP binding site [chemical binding]; other site 309799001135 Q-loop/lid; other site 309799001136 ABC transporter signature motif; other site 309799001137 Walker B; other site 309799001138 D-loop; other site 309799001139 H-loop/switch region; other site 309799001140 DinB family; Region: DinB; cl17821 309799001141 DinB superfamily; Region: DinB_2; pfam12867 309799001142 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 309799001143 Major Facilitator Superfamily; Region: MFS_1; pfam07690 309799001144 putative substrate translocation pore; other site 309799001145 peroxiredoxin; Provisional; Region: PRK13189 309799001146 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 309799001147 dimer interface [polypeptide binding]; other site 309799001148 decamer (pentamer of dimers) interface [polypeptide binding]; other site 309799001149 catalytic triad [active] 309799001150 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 309799001151 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 309799001152 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 309799001153 NAD(P) binding site [chemical binding]; other site 309799001154 homodimer interface [polypeptide binding]; other site 309799001155 substrate binding site [chemical binding]; other site 309799001156 active site 309799001157 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 309799001158 active site 309799001159 UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350 309799001160 homodimer interface [polypeptide binding]; other site 309799001161 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; Region: UDPG_MGDP_dh_N; pfam03721 309799001162 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 309799001163 NAD(P) binding site [chemical binding]; other site 309799001164 active site 309799001165 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 309799001166 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 309799001167 thioester formation/cholesterol transfer; other site 309799001168 Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; smart00305 309799001169 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 309799001170 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 309799001171 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 309799001172 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 309799001173 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 309799001174 Protein of unknown function (DUF2283); Region: DUF2283; pfam10049 309799001175 putative trimer interface [polypeptide binding]; other site 309799001176 Bacterial transferase hexapeptide (six repeats); Region: Hexapep; pfam00132 309799001177 putative CoA binding site [chemical binding]; other site 309799001178 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 309799001179 putative trimer interface [polypeptide binding]; other site 309799001180 putative active site [active] 309799001181 putative substrate binding site [chemical binding]; other site 309799001182 putative CoA binding site [chemical binding]; other site 309799001183 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 309799001184 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 309799001185 acyl-activating enzyme (AAE) consensus motif; other site 309799001186 AMP binding site [chemical binding]; other site 309799001187 active site 309799001188 CoA binding site [chemical binding]; other site 309799001189 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 309799001190 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 309799001191 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 309799001192 colanic acid biosynthesis glycosyl transferase WcaI; Region: wcaI; TIGR04007 309799001193 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 309799001194 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 309799001195 inhibitor-cofactor binding pocket; inhibition site 309799001196 pyridoxal 5'-phosphate binding site [chemical binding]; other site 309799001197 catalytic residue [active] 309799001198 Bacterial sugar transferase; Region: Bac_transf; pfam02397 309799001199 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 309799001200 active site 309799001201 NTP binding site [chemical binding]; other site 309799001202 metal binding triad [ion binding]; metal-binding site 309799001203 antibiotic binding site [chemical binding]; other site 309799001204 HEPN domain; Region: HEPN; pfam05168 309799001205 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 309799001206 polysaccharide export protein EpsE; Region: EpsE; TIGR03028 309799001207 SLBB domain; Region: SLBB; pfam10531 309799001208 SLBB domain; Region: SLBB; pfam10531 309799001209 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 309799001210 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 309799001211 SLBB domain; Region: SLBB; pfam10531 309799001212 polysaccharide export protein EpsE; Region: EpsE; TIGR03028 309799001213 SLBB domain; Region: SLBB; pfam10531 309799001214 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 309799001215 SLBB domain; Region: SLBB; pfam10531 309799001216 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 309799001217 SLBB domain; Region: SLBB; pfam10531 309799001218 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 309799001219 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 309799001220 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 309799001221 Uncharacterized conserved protein [Function unknown]; Region: COG2135 309799001222 M6 family metalloprotease domain; Region: M6dom_TIGR03296 309799001223 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 309799001224 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 309799001225 Protein of unknown function DUF89; Region: DUF89; cl15397 309799001226 CRISPR-associated (Cas) DxTHG family; Region: Cas_DxTHG; pfam09455 309799001227 CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cl17439 309799001228 CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cl14784 309799001229 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 309799001230 active site 309799001231 putative GTP cyclohydrolase; Provisional; Region: PRK13674 309799001232 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 309799001233 dihydropteroate synthase; Region: DHPS; TIGR01496 309799001234 substrate binding pocket [chemical binding]; other site 309799001235 dimer interface [polypeptide binding]; other site 309799001236 inhibitor binding site; inhibition site 309799001237 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 309799001238 catalytic center binding site [active] 309799001239 ATP binding site [chemical binding]; other site 309799001240 Creatinine amidohydrolase; Region: Creatininase; cl00618 309799001241 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 309799001242 TPR motif; other site 309799001243 binding surface 309799001244 Tetratricopeptide repeat; Region: TPR_12; pfam13424 309799001245 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 309799001246 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 309799001247 metal binding site [ion binding]; metal-binding site 309799001248 active site 309799001249 I-site; other site 309799001250 Glycosyl hydrolase family 12; Region: Glyco_hydro_12; cl03302 309799001251 Glycosyl hydrolase family 26; Region: Glyco_hydro_26; pfam02156 309799001252 Predicted transcriptional regulators [Transcription]; Region: COG1725 309799001253 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 309799001254 DNA-binding site [nucleotide binding]; DNA binding site 309799001255 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 309799001256 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 309799001257 Walker A/P-loop; other site 309799001258 ATP binding site [chemical binding]; other site 309799001259 Q-loop/lid; other site 309799001260 ABC transporter signature motif; other site 309799001261 Walker B; other site 309799001262 D-loop; other site 309799001263 H-loop/switch region; other site 309799001264 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 309799001265 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 309799001266 Walker A/P-loop; other site 309799001267 ATP binding site [chemical binding]; other site 309799001268 Q-loop/lid; other site 309799001269 ABC transporter signature motif; other site 309799001270 Walker B; other site 309799001271 D-loop; other site 309799001272 H-loop/switch region; other site 309799001273 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 309799001274 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 309799001275 FtsX-like permease family; Region: FtsX; pfam02687 309799001276 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 309799001277 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 309799001278 putative NAD(P) binding site [chemical binding]; other site 309799001279 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 309799001280 Predicted GTPase [General function prediction only]; Region: DRG; COG1163 309799001281 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 309799001282 G1 box; other site 309799001283 GTP/Mg2+ binding site [chemical binding]; other site 309799001284 G2 box; other site 309799001285 Switch I region; other site 309799001286 G3 box; other site 309799001287 Switch II region; other site 309799001288 G4 box; other site 309799001289 G5 box; other site 309799001290 The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information...; Region: TGS; cl15768 309799001291 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 309799001292 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 309799001293 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 309799001294 MarR family; Region: MarR_2; pfam12802 309799001295 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 309799001296 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 309799001297 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 309799001298 Walker A/P-loop; other site 309799001299 ATP binding site [chemical binding]; other site 309799001300 Q-loop/lid; other site 309799001301 ABC transporter signature motif; other site 309799001302 Walker B; other site 309799001303 D-loop; other site 309799001304 H-loop/switch region; other site 309799001305 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 309799001306 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 309799001307 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 309799001308 Walker A/P-loop; other site 309799001309 ATP binding site [chemical binding]; other site 309799001310 Q-loop/lid; other site 309799001311 ABC transporter signature motif; other site 309799001312 Walker B; other site 309799001313 D-loop; other site 309799001314 H-loop/switch region; other site 309799001315 DOMON-like type 9 carbohydrate binding module of xylanases; Region: CBM9_like_1; cd00005 309799001316 Ca binding site [ion binding]; other site 309799001317 carbohydrate binding site [chemical binding]; other site 309799001318 EamA-like transporter family; Region: EamA; pfam00892 309799001319 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 309799001320 EamA-like transporter family; Region: EamA; pfam00892 309799001321 KduI/IolB family; Region: KduI; pfam04962 309799001322 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 309799001323 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 309799001324 active site 309799001325 intersubunit interface [polypeptide binding]; other site 309799001326 catalytic residue [active] 309799001327 N-terminal domain of chitobiose phosphorylase (ChBP) and similar proteins; Region: GH94N_ChBP_like; cd11755 309799001328 catalytic domain interface [polypeptide binding]; other site 309799001329 putative homodimer interface [polypeptide binding]; other site 309799001330 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 309799001331 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 309799001332 N-terminal domain of cellobiose phosphorylase (CBP) and similar proteins; Region: GH94N_CBP_like; cd11754 309799001333 catalytic domain interface [polypeptide binding]; other site 309799001334 homodimer interface [polypeptide binding]; other site 309799001335 putative active site [active] 309799001336 alpha-glucosidase; Provisional; Region: PRK10426 309799001337 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 309799001338 Alpha-glucosidase II (alpha-D-glucoside glucohydrolase) is a glycosyl hydrolase family 31 (GH31) enzyme, found in bacteria and plants, which has exo-alpha-1,4-glucosidase and oligo-1,6-glucosidase activities. Alpha-glucosidase II has been characterized...; Region: GH31_glucosidase_II_MalA; cd06604 309799001339 trimer interface [polypeptide binding]; other site 309799001340 active site 309799001341 homohexamer (dimer of homotrimer) interface [polypeptide binding]; other site 309799001342 catalytic site [active] 309799001343 H+ Antiporter protein; Region: 2A0121; TIGR00900 309799001344 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 309799001345 putative substrate translocation pore; other site 309799001346 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 309799001347 dimerization interface [polypeptide binding]; other site 309799001348 putative active cleft [active] 309799001349 GIY-YIG domain of hypothetical proteins from archaea and their bacterial homologs; Region: GIY-YIG_COG1833; cd10441 309799001350 GIY-YIG motif/motif A; other site 309799001351 putative active site [active] 309799001352 putative metal binding site [ion binding]; other site 309799001353 LysE type translocator; Region: LysE; pfam01810 309799001354 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 309799001355 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 309799001356 putative active site [active] 309799001357 putative metal binding site [ion binding]; other site 309799001358 Domain of unknown function (DUF377); Region: DUF377; pfam04041 309799001359 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 309799001360 active site 309799001361 BioY family; Region: BioY; pfam02632 309799001362 PspC domain; Region: PspC; pfam04024 309799001363 PspC domain; Region: PspC; pfam04024 309799001364 Transcriptional regulators [Transcription]; Region: PurR; COG1609 309799001365 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 309799001366 DNA binding site [nucleotide binding] 309799001367 domain linker motif; other site 309799001368 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 309799001369 dimerization interface [polypeptide binding]; other site 309799001370 ligand binding site [chemical binding]; other site 309799001371 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 309799001372 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 309799001373 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 309799001374 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 309799001375 dimer interface [polypeptide binding]; other site 309799001376 conserved gate region; other site 309799001377 putative PBP binding loops; other site 309799001378 ABC-ATPase subunit interface; other site 309799001379 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 309799001380 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 309799001381 dimer interface [polypeptide binding]; other site 309799001382 conserved gate region; other site 309799001383 putative PBP binding loops; other site 309799001384 ABC-ATPase subunit interface; other site 309799001385 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 309799001386 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 309799001387 Walker A/P-loop; other site 309799001388 ATP binding site [chemical binding]; other site 309799001389 Q-loop/lid; other site 309799001390 ABC transporter signature motif; other site 309799001391 Walker B; other site 309799001392 D-loop; other site 309799001393 H-loop/switch region; other site 309799001394 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 309799001395 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 309799001396 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 309799001397 Walker A/P-loop; other site 309799001398 ATP binding site [chemical binding]; other site 309799001399 Q-loop/lid; other site 309799001400 ABC transporter signature motif; other site 309799001401 Walker B; other site 309799001402 D-loop; other site 309799001403 H-loop/switch region; other site 309799001404 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 309799001405 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 309799001406 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 309799001407 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 309799001408 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 309799001409 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 309799001410 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 309799001411 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 309799001412 structural tetrad; other site 309799001413 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 309799001414 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 309799001415 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 309799001416 Walker A/P-loop; other site 309799001417 ATP binding site [chemical binding]; other site 309799001418 Q-loop/lid; other site 309799001419 ABC transporter signature motif; other site 309799001420 Walker B; other site 309799001421 D-loop; other site 309799001422 H-loop/switch region; other site 309799001423 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 309799001424 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 309799001425 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 309799001426 Walker A/P-loop; other site 309799001427 ATP binding site [chemical binding]; other site 309799001428 Q-loop/lid; other site 309799001429 ABC transporter signature motif; other site 309799001430 Walker B; other site 309799001431 D-loop; other site 309799001432 H-loop/switch region; other site 309799001433 Alpha-amylase/alpha-mannosidase [Carbohydrate transport and metabolism]; Region: COG1449 309799001434 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 309799001435 N-terminal catalytic domain of thermoactive amylopullulanases; glycoside hydrolase family 57 (GH57); Region: GH57N_APU; cd10796 309799001436 putative active site [active] 309799001437 catalytic site [active] 309799001438 DOMON-like domain of various glycoside hydrolases; Region: DOMON_glucodextranase_like; cd09626 309799001439 putative ligand binding site [chemical binding]; other site 309799001440 DOMON-like domain of various glycoside hydrolases; Region: DOMON_glucodextranase_like; cd09626 309799001441 putative ligand binding site [chemical binding]; other site 309799001442 Domain of unknown function (DUF955); Region: DUF955; pfam06114 309799001443 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 309799001444 non-specific DNA binding site [nucleotide binding]; other site 309799001445 salt bridge; other site 309799001446 sequence-specific DNA binding site [nucleotide binding]; other site 309799001447 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 309799001448 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 309799001449 oligomer interface [polypeptide binding]; other site 309799001450 active site 309799001451 metal binding site [ion binding]; metal-binding site 309799001452 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 309799001453 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 309799001454 oligomer interface [polypeptide binding]; other site 309799001455 active site 309799001456 metal binding site [ion binding]; metal-binding site 309799001457 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 309799001458 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 309799001459 oligomer interface [polypeptide binding]; other site 309799001460 active site 309799001461 metal binding site [ion binding]; metal-binding site 309799001462 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 309799001463 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 309799001464 minor groove reading motif; other site 309799001465 helix-hairpin-helix signature motif; other site 309799001466 substrate binding pocket [chemical binding]; other site 309799001467 active site 309799001468 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 309799001469 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 309799001470 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 309799001471 active site 309799001472 catalytic tetrad [active] 309799001473 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 309799001474 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 309799001475 L-threonine dehydrogenase; Region: threonine_DH_like; cd08234 309799001476 putative NAD(P) binding site [chemical binding]; other site 309799001477 catalytic Zn binding site [ion binding]; other site 309799001478 putative phosphoesterase; Region: acc_ester; TIGR03729 309799001479 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 309799001480 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 309799001481 putative DNA binding site [nucleotide binding]; other site 309799001482 putative Zn2+ binding site [ion binding]; other site 309799001483 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 309799001484 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 309799001485 nucleotide binding site [chemical binding]; other site 309799001486 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 309799001487 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 309799001488 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 309799001489 Ligand Binding Site [chemical binding]; other site 309799001490 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 309799001491 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 309799001492 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 309799001493 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 309799001494 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 309799001495 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 309799001496 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 309799001497 glutamine binding [chemical binding]; other site 309799001498 catalytic triad [active] 309799001499 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 309799001500 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 309799001501 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 309799001502 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 309799001503 active site 309799001504 ribulose/triose binding site [chemical binding]; other site 309799001505 phosphate binding site [ion binding]; other site 309799001506 substrate (anthranilate) binding pocket [chemical binding]; other site 309799001507 product (indole) binding pocket [chemical binding]; other site 309799001508 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 309799001509 active site 309799001510 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 309799001511 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 309799001512 pyridoxal 5'-phosphate binding site [chemical binding]; other site 309799001513 catalytic residue [active] 309799001514 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 309799001515 substrate binding site [chemical binding]; other site 309799001516 active site 309799001517 catalytic residues [active] 309799001518 heterodimer interface [polypeptide binding]; other site 309799001519 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 309799001520 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 309799001521 NAD(P) binding site [chemical binding]; other site 309799001522 Formiminotransferase-cyclodeaminase; Region: FTCD_C; pfam04961 309799001523 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 309799001524 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 309799001525 substrate-cofactor binding pocket; other site 309799001526 pyridoxal 5'-phosphate binding site [chemical binding]; other site 309799001527 catalytic residue [active] 309799001528 A subgroup of L-lactate dehydrogenases; Region: LDH_2; cd05292 309799001529 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 309799001530 NAD binding site [chemical binding]; other site 309799001531 dimer interface [polypeptide binding]; other site 309799001532 substrate binding site [chemical binding]; other site 309799001533 tetramer (dimer of dimers) interface [polypeptide binding]; other site 309799001534 KaiC domain protein, AF_0795 family; Region: thermo_KaiC_2; TIGR03878 309799001535 KaiC; Region: KaiC; pfam06745 309799001536 Walker A motif; other site 309799001537 ATP binding site [chemical binding]; other site 309799001538 Walker B motif; other site 309799001539 probable regulatory domain; Region: near_KaiC_dom; TIGR03879 309799001540 Predicted RNA-binding protein, contains TRAM domain [General function prediction only]; Region: COG3269 309799001541 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 309799001542 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 309799001543 S-adenosylmethionine binding site [chemical binding]; other site 309799001544 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 309799001545 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 309799001546 Walker A motif; other site 309799001547 ATP binding site [chemical binding]; other site 309799001548 Walker B motif; other site 309799001549 arginine finger; other site 309799001550 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 309799001551 Protein of unknown function DUF58; Region: DUF58; pfam01882 309799001552 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 309799001553 Protein of unknown function (DUF1498); Region: DUF1498; cl17840 309799001554 RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner; Region: RNase_H; cl14782 309799001555 RNA/DNA hybrid binding site [nucleotide binding]; other site 309799001556 active site 309799001557 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 309799001558 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 309799001559 dimer interface [polypeptide binding]; other site 309799001560 conserved gate region; other site 309799001561 putative PBP binding loops; other site 309799001562 ABC-ATPase subunit interface; other site 309799001563 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 309799001564 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 309799001565 dimer interface [polypeptide binding]; other site 309799001566 conserved gate region; other site 309799001567 putative PBP binding loops; other site 309799001568 ABC-ATPase subunit interface; other site 309799001569 maltose ABC transporter periplasmic protein; Reviewed; Region: malE; PRK09474 309799001570 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 309799001571 Domain of unknown function (DUF4330); Region: DUF4330; pfam14221 309799001572 O-Antigen ligase; Region: Wzy_C; cl04850 309799001573 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 309799001574 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 309799001575 putative active site [active] 309799001576 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 309799001577 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 309799001578 active site 309799001579 nucleotide binding site [chemical binding]; other site 309799001580 HIGH motif; other site 309799001581 KMSKS motif; other site 309799001582 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 309799001583 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 309799001584 putative ribose interaction site [chemical binding]; other site 309799001585 putative ADP binding site [chemical binding]; other site 309799001586 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 309799001587 dimer interface [polypeptide binding]; other site 309799001588 active site 309799001589 Histidinol phosphatase and related phosphatases [Amino acid transport and metabolism]; Region: HisB; COG0241 309799001590 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 309799001591 active site 309799001592 motif I; other site 309799001593 motif II; other site 309799001594 nucleotide sugar dehydrogenase; Region: NDP-sugDHase; TIGR03026 309799001595 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 309799001596 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 309799001597 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 309799001598 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 309799001599 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 309799001600 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 309799001601 catalytic residue [active] 309799001602 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 309799001603 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 309799001604 Ligand binding site; other site 309799001605 Putative Catalytic site; other site 309799001606 DXD motif; other site 309799001607 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 309799001608 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 309799001609 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 309799001610 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 309799001611 binding surface 309799001612 TPR motif; other site 309799001613 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 309799001614 binding surface 309799001615 TPR motif; other site 309799001616 Tetratricopeptide repeat; Region: TPR_12; pfam13424 309799001617 Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969 309799001618 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 309799001619 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 309799001620 Transcriptional regulators [Transcription]; Region: PurR; COG1609 309799001621 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 309799001622 DNA binding site [nucleotide binding] 309799001623 domain linker motif; other site 309799001624 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 309799001625 ligand binding site [chemical binding]; other site 309799001626 dimerization interface [polypeptide binding]; other site 309799001627 Predicted cobalamin binding protein [General function prediction only]; Region: COG5012 309799001628 B12 binding domain of corrinoid proteins. A family of small methanogenic corrinoid proteins that bind methyl-Co(III) 5-hydroxybenzimidazolylcobamide as a cofactor. They play a role on the methanogenesis from trimethylamine, dimethylamine or...; Region: corrinoid_protein_B12-BD; cd02070 309799001629 B12 binding site [chemical binding]; other site 309799001630 cobalt ligand [ion binding]; other site 309799001631 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 309799001632 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 309799001633 catalytic loop [active] 309799001634 Uncharacterized metal-binding protein [General function prediction only]; Region: COG3894 309799001635 iron binding site [ion binding]; other site 309799001636 The URO-D _like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases. Uroporphyrinogen decarboxylase (URO-D) decarboxylates the four...; Region: URO-D_like; cd03465 309799001637 Domain of unknown function DUF39; Region: DUF39; pfam01837 309799001638 NIL domain; Region: NIL; pfam09383 309799001639 4Fe-4S binding domain; Region: Fer4; pfam00037 309799001640 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 309799001641 4Fe-4S binding domain; Region: Fer4; cl02805 309799001642 hypothetical protein; Provisional; Region: PRK04334 309799001643 Protein of unknown function (DUF2089); Region: DUF2089; pfam09862 309799001644 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 309799001645 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 309799001646 FtsX-like permease family; Region: FtsX; pfam02687 309799001647 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 309799001648 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 309799001649 HlyD family secretion protein; Region: HlyD_3; pfam13437 309799001650 Zinc dependent phospholipase C (alpha toxin); Region: Zn_dep_PLPC; cd11009 309799001651 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 309799001652 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 309799001653 Walker A/P-loop; other site 309799001654 ATP binding site [chemical binding]; other site 309799001655 Q-loop/lid; other site 309799001656 ABC transporter signature motif; other site 309799001657 Walker B; other site 309799001658 D-loop; other site 309799001659 H-loop/switch region; other site 309799001660 Protein of unknown function (DUF1571); Region: DUF1571; pfam07608 309799001661 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 309799001662 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 309799001663 Part of AAA domain; Region: AAA_19; pfam13245 309799001664 Family description; Region: UvrD_C_2; pfam13538 309799001665 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 309799001666 Response regulator receiver domain; Region: Response_reg; pfam00072 309799001667 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 309799001668 active site 309799001669 phosphorylation site [posttranslational modification] 309799001670 intermolecular recognition site; other site 309799001671 dimerization interface [polypeptide binding]; other site 309799001672 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 309799001673 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 309799001674 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 309799001675 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 309799001676 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 309799001677 dimer interface [polypeptide binding]; other site 309799001678 phosphorylation site [posttranslational modification] 309799001679 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 309799001680 ATP binding site [chemical binding]; other site 309799001681 Mg2+ binding site [ion binding]; other site 309799001682 G-X-G motif; other site 309799001683 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 309799001684 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 309799001685 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 309799001686 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 309799001687 active site 309799001688 B12-binding domain/radical SAM domain protein, MJ_1487 family; Region: B12_SAM_MJ_1487; TIGR04013 309799001689 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 309799001690 B12 binding site [chemical binding]; other site 309799001691 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 309799001692 FeS/SAM binding site; other site 309799001693 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 309799001694 EamA-like transporter family; Region: EamA; pfam00892 309799001695 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 309799001696 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 309799001697 dimerization interface [polypeptide binding]; other site 309799001698 active site 309799001699 Aspartate oxidase [Coenzyme metabolism]; Region: NadB; COG0029 309799001700 L-aspartate oxidase; Provisional; Region: PRK06175 309799001701 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 309799001702 Quinolinate synthetase A protein; Region: NadA; pfam02445 309799001703 Protein of unknown function (DUF1049); Region: DUF1049; pfam06305 309799001704 propanediol utilization phosphotransacylase; Provisional; Region: PRK15070 309799001705 Propanediol utilisation protein PduL; Region: PduL; pfam06130 309799001706 Propanediol utilisation protein PduL; Region: PduL; pfam06130 309799001707 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 309799001708 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 309799001709 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 309799001710 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 309799001711 Glutaredoxin-like domain protein; Region: GlrX_arch; TIGR02187 309799001712 Thioredoxin (TRX)-Glutaredoxin (GRX)-like family; composed of archaeal and bacterial proteins that show similarity to both TRX and GRX, including the C-terminal TRX-fold subdomain of Pyrococcus furiosus protein disulfide oxidoreductase (PfPDO). All...; Region: TRX_GRX_like; cd02973 309799001713 catalytic residues [active] 309799001714 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 309799001715 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 309799001716 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 309799001717 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 309799001718 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 309799001719 active site 309799001720 catalytic tetrad [active] 309799001721 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 309799001722 hypothetical protein; Provisional; Region: PRK13665 309799001723 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 309799001724 Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_like; cd07021 309799001725 dimer interface [polypeptide binding]; other site 309799001726 active site residues [active] 309799001727 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 309799001728 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 309799001729 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 309799001730 Walker A/P-loop; other site 309799001731 ATP binding site [chemical binding]; other site 309799001732 Q-loop/lid; other site 309799001733 ABC transporter signature motif; other site 309799001734 Walker B; other site 309799001735 D-loop; other site 309799001736 H-loop/switch region; other site 309799001737 ABC nitrate/sulfonate/bicarbonate family transporter, ATPase subunit; Region: ABC_transp; pfam09821 309799001738 ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism]; Region: COG4986 309799001739 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 309799001740 dimer interface [polypeptide binding]; other site 309799001741 conserved gate region; other site 309799001742 putative PBP binding loops; other site 309799001743 ABC-ATPase subunit interface; other site 309799001744 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 309799001745 dimer interface [polypeptide binding]; other site 309799001746 conserved gate region; other site 309799001747 putative PBP binding loops; other site 309799001748 ABC-ATPase subunit interface; other site 309799001749 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 309799001750 N-terminal catalytic domain of thermoactive amylopullulanases; glycoside hydrolase family 57 (GH57); Region: GH57N_APU; cd10796 309799001751 putative active site [active] 309799001752 catalytic site [active] 309799001753 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 309799001754 Active_site [active] 309799001755 Protein of unknown function (DUF763); Region: DUF763; pfam05559 309799001756 Uncharacterized ACR, COG1430; Region: DUF192; pfam02643 309799001757 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 309799001758 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 309799001759 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 309799001760 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 309799001761 SCP-2 sterol transfer family; Region: SCP2; cl01225 309799001762 Uncharacterized conserved protein [Function unknown]; Region: COG1633 309799001763 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045 309799001764 diiron binding motif [ion binding]; other site 309799001765 diaminopimelate epimerase; Provisional; Region: PRK13577 309799001766 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 309799001767 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 309799001768 ATP-dependent DNA ligase; Provisional; Region: PRK01109 309799001769 Adenylation domain of archaeal and bacterial LigB-like DNA ligases; Region: Adenylation_DNA_ligase_Arch_LigB; cd07901 309799001770 active site 309799001771 DNA binding site [nucleotide binding] 309799001772 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase I is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_I; cd07969 309799001773 DNA binding site [nucleotide binding] 309799001774 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 309799001775 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 309799001776 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 309799001777 Zn2+ binding site [ion binding]; other site 309799001778 Mg2+ binding site [ion binding]; other site 309799001779 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 309799001780 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 309799001781 Substrate binding site; other site 309799001782 Mg++ binding site; other site 309799001783 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 309799001784 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 309799001785 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 309799001786 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 309799001787 active site 309799001788 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 309799001789 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 309799001790 5S rRNA interface [nucleotide binding]; other site 309799001791 CTC domain interface [polypeptide binding]; other site 309799001792 L16 interface [polypeptide binding]; other site 309799001793 EDD domain protein, DegV family; Region: DegV; TIGR00762 309799001794 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 309799001795 ncharacterized protein conserved in bacteria [Function unknown]; Region: SpoIIIAA; COG3854 309799001796 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 309799001797 Walker A motif; other site 309799001798 ATP binding site [chemical binding]; other site 309799001799 Walker B motif; other site 309799001800 R3H domain of a group of proteins with unknown function, who also contain a AAA-ATPase (AAA) domain. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. The function of the domain is...; Region: R3H_AAA; cd02645 309799001801 RxxxH motif; other site 309799001802 thymidylate kinase; Validated; Region: tmk; PRK00698 309799001803 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 309799001804 TMP-binding site; other site 309799001805 ATP-binding site [chemical binding]; other site 309799001806 Protein of unknown function (DUF970); Region: DUF970; cl17525 309799001807 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 309799001808 DNA polymerase III, delta' subunit; Region: holB; TIGR00678 309799001809 Walker A motif; other site 309799001810 ATP binding site [chemical binding]; other site 309799001811 Walker B motif; other site 309799001812 ATPase involved in DNA replication [DNA replication, recombination, and repair]; Region: HolB; COG0470 309799001813 arginine finger; other site 309799001814 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 309799001815 recombination factor protein RarA; Reviewed; Region: PRK13342 309799001816 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 309799001817 Walker A motif; other site 309799001818 ATP binding site [chemical binding]; other site 309799001819 Walker B motif; other site 309799001820 arginine finger; other site 309799001821 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 309799001822 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 309799001823 NodB motif; other site 309799001824 putative active site [active] 309799001825 putative catalytic site [active] 309799001826 Zn binding site [ion binding]; other site 309799001827 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 309799001828 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 309799001829 putative substrate binding site [chemical binding]; other site 309799001830 putative ATP binding site [chemical binding]; other site 309799001831 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 309799001832 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 309799001833 active site 309799001834 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 309799001835 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 309799001836 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 309799001837 putative substrate binding region [chemical binding]; other site 309799001838 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 309799001839 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 309799001840 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 309799001841 Domain of unknown function (DUF3552); Region: DUF3552; pfam12072 309799001842 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 309799001843 uncharacterized domain HDIG; Region: HDIG; TIGR00277 309799001844 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 309799001845 putative active site [active] 309799001846 metal binding site [ion binding]; metal-binding site 309799001847 homodimer binding site [polypeptide binding]; other site 309799001848 Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232 309799001849 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 309799001850 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 309799001851 thymidine kinase; Provisional; Region: PRK04296 309799001852 Protein of unknown function (DUF1385); Region: DUF1385; pfam07136 309799001853 peptide chain release factor 1; Validated; Region: prfA; PRK00591 309799001854 This domain is found in peptide chain release factors; Region: PCRF; smart00937 309799001855 RF-1 domain; Region: RF-1; pfam00472 309799001856 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 309799001857 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 309799001858 S-adenosylmethionine binding site [chemical binding]; other site 309799001859 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 309799001860 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 309799001861 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 309799001862 Low molecular weight phosphatase family; Region: LMWPc; cd00115 309799001863 active site 309799001864 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 309799001865 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 309799001866 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 309799001867 dimer interface [polypeptide binding]; other site 309799001868 active site 309799001869 glycine-pyridoxal phosphate binding site [chemical binding]; other site 309799001870 folate binding site [chemical binding]; other site 309799001871 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 309799001872 active site 309799001873 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 309799001874 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 309799001875 hinge; other site 309799001876 active site 309799001877 Family of unknown function (DUF490); Region: DUF490; pfam04357 309799001878 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 309799001879 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 309799001880 Outer membrane protein/protective antigen OMA87 [Cell envelope biogenesis, outer membrane]; Region: COG4775 309799001881 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 309799001882 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 309799001883 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 309799001884 Surface antigen; Region: Bac_surface_Ag; pfam01103 309799001885 Surface antigen; Region: Bac_surface_Ag; pfam01103 309799001886 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 309799001887 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 309799001888 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 309799001889 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 309799001890 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 309799001891 trimer interface [polypeptide binding]; other site 309799001892 active site 309799001893 UDP-GlcNAc binding site [chemical binding]; other site 309799001894 lipid binding site [chemical binding]; lipid-binding site 309799001895 UDP-3-O-acyl-N-acetylglucosamine deacetylase [Cell envelope biogenesis, outer membrane]; Region: LpxC; cl00512 309799001896 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 309799001897 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 309799001898 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 309799001899 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 309799001900 active site 309799001901 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 309799001902 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 309799001903 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 309799001904 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 309799001905 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 309799001906 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 309799001907 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 309799001908 Walker A/P-loop; other site 309799001909 ATP binding site [chemical binding]; other site 309799001910 Q-loop/lid; other site 309799001911 ABC transporter signature motif; other site 309799001912 Walker B; other site 309799001913 D-loop; other site 309799001914 H-loop/switch region; other site 309799001915 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 309799001916 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 309799001917 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 309799001918 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 309799001919 binding surface 309799001920 TPR motif; other site 309799001921 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 309799001922 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 309799001923 Walker A/P-loop; other site 309799001924 ATP binding site [chemical binding]; other site 309799001925 Q-loop/lid; other site 309799001926 ABC transporter signature motif; other site 309799001927 Walker B; other site 309799001928 D-loop; other site 309799001929 H-loop/switch region; other site 309799001930 Protein of unknown function (DUF3084); Region: DUF3084; pfam11283 309799001931 prolyl-tRNA synthetase; Provisional; Region: PRK08661 309799001932 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778 309799001933 dimer interface [polypeptide binding]; other site 309799001934 motif 1; other site 309799001935 active site 309799001936 motif 2; other site 309799001937 motif 3; other site 309799001938 ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862 309799001939 anticodon binding site; other site 309799001940 zinc-binding site [ion binding]; other site 309799001941 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 309799001942 trimer interface [polypeptide binding]; other site 309799001943 active site 309799001944 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 309799001945 elongation factor G; Reviewed; Region: PRK12740 309799001946 G1 box; other site 309799001947 putative GEF interaction site [polypeptide binding]; other site 309799001948 GTP/Mg2+ binding site [chemical binding]; other site 309799001949 Switch I region; other site 309799001950 G2 box; other site 309799001951 G3 box; other site 309799001952 Switch II region; other site 309799001953 G4 box; other site 309799001954 G5 box; other site 309799001955 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 309799001956 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 309799001957 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 309799001958 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 309799001959 gamma-glutamyl kinase; Provisional; Region: PRK05429 309799001960 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 309799001961 nucleotide binding site [chemical binding]; other site 309799001962 homotetrameric interface [polypeptide binding]; other site 309799001963 putative phosphate binding site [ion binding]; other site 309799001964 putative allosteric binding site; other site 309799001965 PUA domain; Region: PUA; pfam01472 309799001966 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 309799001967 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 309799001968 Walker A/P-loop; other site 309799001969 ATP binding site [chemical binding]; other site 309799001970 Q-loop/lid; other site 309799001971 ABC transporter signature motif; other site 309799001972 Walker B; other site 309799001973 D-loop; other site 309799001974 H-loop/switch region; other site 309799001975 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 309799001976 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 309799001977 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 309799001978 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 309799001979 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 309799001980 HlyD family secretion protein; Region: HlyD_3; pfam13437 309799001981 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 309799001982 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 309799001983 FtsX-like permease family; Region: FtsX; pfam02687 309799001984 glycerol kinase; Provisional; Region: glpK; PRK00047 309799001985 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 309799001986 N- and C-terminal domain interface [polypeptide binding]; other site 309799001987 active site 309799001988 MgATP binding site [chemical binding]; other site 309799001989 catalytic site [active] 309799001990 metal binding site [ion binding]; metal-binding site 309799001991 glycerol binding site [chemical binding]; other site 309799001992 homotetramer interface [polypeptide binding]; other site 309799001993 homodimer interface [polypeptide binding]; other site 309799001994 FBP binding site [chemical binding]; other site 309799001995 protein IIAGlc interface [polypeptide binding]; other site 309799001996 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 309799001997 RNA polymerase sigma factor SigW; Provisional; Region: PRK09641 309799001998 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 309799001999 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 309799002000 DNA binding residues [nucleotide binding] 309799002001 Putative zinc-finger; Region: zf-HC2; pfam13490 309799002002 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 309799002003 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 309799002004 endonuclease III; Region: ENDO3c; smart00478 309799002005 minor groove reading motif; other site 309799002006 helix-hairpin-helix signature motif; other site 309799002007 substrate binding pocket [chemical binding]; other site 309799002008 active site 309799002009 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 309799002010 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 309799002011 purine monophosphate binding site [chemical binding]; other site 309799002012 dimer interface [polypeptide binding]; other site 309799002013 putative catalytic residues [active] 309799002014 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 309799002015 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 309799002016 Bifunctional nuclease; Region: DNase-RNase; pfam02577 309799002017 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 309799002018 EamA-like transporter family; Region: EamA; pfam00892 309799002019 Predicted membrane protein [Function unknown]; Region: COG3601 309799002020 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 309799002021 EDD domain protein, DegV family; Region: DegV; TIGR00762 309799002022 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 309799002023 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 309799002024 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 309799002025 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 309799002026 Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684 309799002027 Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378 309799002028 trimer interface [polypeptide binding]; other site 309799002029 putative Zn binding site [ion binding]; other site 309799002030 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 309799002031 DNA-binding site [nucleotide binding]; DNA binding site 309799002032 Transcriptional regulators [Transcription]; Region: PurR; COG1609 309799002033 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 309799002034 ligand binding site [chemical binding]; other site 309799002035 dimerization interface [polypeptide binding]; other site 309799002036 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 309799002037 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 309799002038 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 309799002039 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 309799002040 dimer interface [polypeptide binding]; other site 309799002041 conserved gate region; other site 309799002042 putative PBP binding loops; other site 309799002043 ABC-ATPase subunit interface; other site 309799002044 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 309799002045 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 309799002046 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 309799002047 dimer interface [polypeptide binding]; other site 309799002048 conserved gate region; other site 309799002049 putative PBP binding loops; other site 309799002050 ABC-ATPase subunit interface; other site 309799002051 Glycosyl hydrolase family 53; Region: Glyco_hydro_53; cl06672 309799002052 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 309799002053 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 309799002054 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 309799002055 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 309799002056 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 309799002057 peptide binding site [polypeptide binding]; other site 309799002058 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 309799002059 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 309799002060 dimer interface [polypeptide binding]; other site 309799002061 conserved gate region; other site 309799002062 putative PBP binding loops; other site 309799002063 ABC-ATPase subunit interface; other site 309799002064 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 309799002065 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 309799002066 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 309799002067 dimer interface [polypeptide binding]; other site 309799002068 conserved gate region; other site 309799002069 putative PBP binding loops; other site 309799002070 ABC-ATPase subunit interface; other site 309799002071 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 309799002072 active site 309799002073 dimer interfaces [polypeptide binding]; other site 309799002074 catalytic residues [active] 309799002075 S-layer homology domain; Region: SLH; pfam00395 309799002076 Protein of unknown function (DUF2397); Region: DUF2397; pfam09660 309799002077 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 309799002078 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 309799002079 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 309799002080 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 309799002081 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 309799002082 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 309799002083 pyridoxal 5'-phosphate binding site [chemical binding]; other site 309799002084 homodimer interface [polypeptide binding]; other site 309799002085 catalytic residue [active] 309799002086 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 309799002087 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 309799002088 putative substrate binding site [chemical binding]; other site 309799002089 putative ATP binding site [chemical binding]; other site 309799002090 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 309799002091 binding surface 309799002092 TPR motif; other site 309799002093 TPR repeat; Region: TPR_11; pfam13414 309799002094 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 309799002095 binding surface 309799002096 TPR motif; other site 309799002097 FtsH Extracellular; Region: FtsH_ext; pfam06480 309799002098 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 309799002099 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 309799002100 Walker A motif; other site 309799002101 ATP binding site [chemical binding]; other site 309799002102 Walker B motif; other site 309799002103 arginine finger; other site 309799002104 Peptidase family M41; Region: Peptidase_M41; pfam01434 309799002105 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 309799002106 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 309799002107 Ligand Binding Site [chemical binding]; other site 309799002108 TilS substrate C-terminal domain; Region: TilS_C; smart00977 309799002109 YceG-like family; Region: YceG; pfam02618 309799002110 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 309799002111 dimerization interface [polypeptide binding]; other site 309799002112 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 309799002113 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 309799002114 active site 309799002115 motif I; other site 309799002116 motif II; other site 309799002117 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 309799002118 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 309799002119 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 309799002120 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 309799002121 Walker A motif; other site 309799002122 ATP binding site [chemical binding]; other site 309799002123 Walker B motif; other site 309799002124 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 309799002125 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 309799002126 Walker A motif; other site 309799002127 ATP binding site [chemical binding]; other site 309799002128 Walker B motif; other site 309799002129 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 309799002130 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 309799002131 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 309799002132 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 309799002133 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 309799002134 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 309799002135 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 309799002136 DNA binding residues [nucleotide binding] 309799002137 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 309799002138 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 309799002139 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 309799002140 hypothetical protein; Reviewed; Region: PRK00024 309799002141 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 309799002142 MPN+ (JAMM) motif; other site 309799002143 Zinc-binding site [ion binding]; other site 309799002144 DNA polymerase I; Provisional; Region: PRK05755 309799002145 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 309799002146 active site 309799002147 metal binding site 1 [ion binding]; metal-binding site 309799002148 putative 5' ssDNA interaction site; other site 309799002149 metal binding site 3; metal-binding site 309799002150 metal binding site 2 [ion binding]; metal-binding site 309799002151 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 309799002152 putative DNA binding site [nucleotide binding]; other site 309799002153 putative metal binding site [ion binding]; other site 309799002154 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 309799002155 active site 309799002156 catalytic site [active] 309799002157 substrate binding site [chemical binding]; other site 309799002158 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 309799002159 active site 309799002160 DNA binding site [nucleotide binding] 309799002161 catalytic site [active] 309799002162 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 309799002163 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 309799002164 CoA-binding site [chemical binding]; other site 309799002165 excinuclease ABC subunit B; Provisional; Region: PRK05298 309799002166 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 309799002167 ATP binding site [chemical binding]; other site 309799002168 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 309799002169 nucleotide binding region [chemical binding]; other site 309799002170 ATP-binding site [chemical binding]; other site 309799002171 Ultra-violet resistance protein B; Region: UvrB; pfam12344 309799002172 UvrB/uvrC motif; Region: UVR; pfam02151 309799002173 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 309799002174 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 309799002175 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 309799002176 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 309799002177 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 309799002178 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 309799002179 DNA binding site [nucleotide binding] 309799002180 active site 309799002181 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 309799002182 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 309799002183 nucleotide binding site [chemical binding]; other site 309799002184 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 309799002185 Bacterial sugar transferase; Region: Bac_transf; pfam02397 309799002186 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 309799002187 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 309799002188 active site 309799002189 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 309799002190 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 309799002191 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 309799002192 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 309799002193 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 309799002194 motif II; other site 309799002195 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 309799002196 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 309799002197 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 309799002198 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 309799002199 Walker A/P-loop; other site 309799002200 ATP binding site [chemical binding]; other site 309799002201 Q-loop/lid; other site 309799002202 ABC transporter signature motif; other site 309799002203 Walker B; other site 309799002204 D-loop; other site 309799002205 H-loop/switch region; other site 309799002206 TOBE domain; Region: TOBE_2; pfam08402 309799002207 Uncharacterized conserved protein [Function unknown]; Region: COG1543 309799002208 N-terminal catalytic domain of Gh57 branching enzyme TK 1436 and similar proteins; Region: GH57N_BE_TK1436_like; cd10816 309799002209 active site 309799002210 substrate binding site [chemical binding]; other site 309799002211 catalytic site [active] 309799002212 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 309799002213 N-terminal catalytic domain of 4-alpha-glucanotransferase; glycoside hydrolase family 57 (GH57); Region: GH57N_TLGT_like; cd10793 309799002214 Glycosyl hydrolase family 57; Region: Glyco_hydro_57; pfam03065 309799002215 active site 309799002216 catalytic site [active] 309799002217 homodimer interface [polypeptide binding]; other site 309799002218 Lid 1; other site 309799002219 Domain of unknown function (DUF1925); Region: DUF1925; pfam09094 309799002220 Domain of unknown function (DUF1926); Region: DUF1926; pfam09095 309799002221 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 309799002222 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 309799002223 active site 309799002224 dimerization interface [polypeptide binding]; other site 309799002225 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 309799002226 Clp amino terminal domain; Region: Clp_N; pfam02861 309799002227 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 309799002228 Walker A motif; other site 309799002229 ATP binding site [chemical binding]; other site 309799002230 Walker B motif; other site 309799002231 arginine finger; other site 309799002232 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 309799002233 Walker A motif; other site 309799002234 ATP binding site [chemical binding]; other site 309799002235 Walker B motif; other site 309799002236 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 309799002237 Adenosine specific kinase; Region: Adenosine_kin; pfam04008 309799002238 Cytidylate kinase-like family; Region: Cytidylate_kin2; pfam13189 309799002239 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 309799002240 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 309799002241 PhoU domain; Region: PhoU; pfam01895 309799002242 PhoU domain; Region: PhoU; pfam01895 309799002243 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 309799002244 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 309799002245 homotetramer interface [polypeptide binding]; other site 309799002246 ligand binding site [chemical binding]; other site 309799002247 catalytic site [active] 309799002248 NAD binding site [chemical binding]; other site 309799002249 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 309799002250 heat shock protein HtpX; Provisional; Region: PRK04897 309799002251 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 309799002252 FMN binding site [chemical binding]; other site 309799002253 dimer interface [polypeptide binding]; other site 309799002254 hypothetical protein; Provisional; Region: PRK10279 309799002255 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 309799002256 active site 309799002257 nucleophile elbow; other site 309799002258 DRTGG domain; Region: DRTGG; pfam07085 309799002259 FOG: CBS domain [General function prediction only]; Region: COG0517 309799002260 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 309799002261 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 309799002262 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 309799002263 ATP binding site [chemical binding]; other site 309799002264 Mg2+ binding site [ion binding]; other site 309799002265 G-X-G motif; other site 309799002266 4Fe-4S binding domain; Region: Fer4_6; pfam12837 309799002267 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 309799002268 Putative Fe-S cluster; Region: FeS; cl17515 309799002269 DRTGG domain; Region: DRTGG; pfam07085 309799002270 DRTGG domain; Region: DRTGG; pfam07085 309799002271 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432 309799002272 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 309799002273 active site 309799002274 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432 309799002275 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 309799002276 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 309799002277 putative dimer interface [polypeptide binding]; other site 309799002278 [2Fe-2S] cluster binding site [ion binding]; other site 309799002279 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 309799002280 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 309799002281 ATP binding site [chemical binding]; other site 309799002282 Mg2+ binding site [ion binding]; other site 309799002283 G-X-G motif; other site 309799002284 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 309799002285 dimer interface [polypeptide binding]; other site 309799002286 [2Fe-2S] cluster binding site [ion binding]; other site 309799002287 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 309799002288 dimer interface [polypeptide binding]; other site 309799002289 [2Fe-2S] cluster binding site [ion binding]; other site 309799002290 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 309799002291 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 309799002292 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 309799002293 4Fe-4S binding domain; Region: Fer4; pfam00037 309799002294 Cupin domain; Region: Cupin_2; pfam07883 309799002295 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 309799002296 N- and C-terminal domain interface [polypeptide binding]; other site 309799002297 D-xylulose kinase; Region: XylB; TIGR01312 309799002298 active site 309799002299 MgATP binding site [chemical binding]; other site 309799002300 catalytic site [active] 309799002301 metal binding site [ion binding]; metal-binding site 309799002302 xylulose binding site [chemical binding]; other site 309799002303 homodimer interface [polypeptide binding]; other site 309799002304 S-adenosylmethionine synthetase; Provisional; Region: PRK04439 309799002305 lysyl-tRNA synthetase; Reviewed; Region: lysK; PRK00750 309799002306 catalytic core domain of class I lysyl tRNA synthetase; Region: LysRS_core_class_I; cd00674 309799002307 active site 309799002308 HIGH motif; other site 309799002309 KMSKS motif; other site 309799002310 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 309799002311 active site 309799002312 peptide modification radical SAM enzyme, YydG family; Region: rSAM_yydG; TIGR04078 309799002313 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 309799002314 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 309799002315 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 309799002316 putative ADP-binding pocket [chemical binding]; other site 309799002317 Zinc dependent phospholipase C/S1-P1 nuclease; Region: ZnPC_S1P1; cd10981 309799002318 Zn binding site [ion binding]; other site 309799002319 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 309799002320 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182 309799002321 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 309799002322 N-ethylammeline chlorohydrolase; Provisional; Region: PRK06038 309799002323 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 309799002324 active site 309799002325 putative substrate binding pocket [chemical binding]; other site 309799002326 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 309799002327 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 309799002328 Dimer interface [polypeptide binding]; other site 309799002329 anticodon binding site; other site 309799002330 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 309799002331 homodimer interface [polypeptide binding]; other site 309799002332 motif 1; other site 309799002333 motif 2; other site 309799002334 active site 309799002335 motif 3; other site 309799002336 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 309799002337 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 309799002338 putative ligand binding site [chemical binding]; other site 309799002339 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 309799002340 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 309799002341 TM-ABC transporter signature motif; other site 309799002342 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 309799002343 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 309799002344 TM-ABC transporter signature motif; other site 309799002345 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 309799002346 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 309799002347 Walker A/P-loop; other site 309799002348 ATP binding site [chemical binding]; other site 309799002349 Q-loop/lid; other site 309799002350 ABC transporter signature motif; other site 309799002351 Walker B; other site 309799002352 D-loop; other site 309799002353 H-loop/switch region; other site 309799002354 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 309799002355 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 309799002356 Walker A/P-loop; other site 309799002357 ATP binding site [chemical binding]; other site 309799002358 Q-loop/lid; other site 309799002359 ABC transporter signature motif; other site 309799002360 Walker B; other site 309799002361 D-loop; other site 309799002362 H-loop/switch region; other site 309799002363 FOG: CBS domain [General function prediction only]; Region: COG0517 309799002364 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc2; cd04585 309799002365 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 309799002366 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 309799002367 propionate/acetate kinase; Provisional; Region: PRK12379 309799002368 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 309799002369 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 309799002370 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 309799002371 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 309799002372 dimer interface [polypeptide binding]; other site 309799002373 active site 309799002374 CoA binding pocket [chemical binding]; other site 309799002375 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 309799002376 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 309799002377 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 309799002378 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 309799002379 NAD(P) binding site [chemical binding]; other site 309799002380 homotetramer interface [polypeptide binding]; other site 309799002381 homodimer interface [polypeptide binding]; other site 309799002382 active site 309799002383 acyl carrier protein; Provisional; Region: acpP; PRK00982 309799002384 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 309799002385 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 309799002386 dimer interface [polypeptide binding]; other site 309799002387 active site 309799002388 ribonuclease III; Reviewed; Region: rnc; PRK00102 309799002389 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 309799002390 dimerization interface [polypeptide binding]; other site 309799002391 active site 309799002392 metal binding site [ion binding]; metal-binding site 309799002393 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 309799002394 dsRNA binding site [nucleotide binding]; other site 309799002395 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 309799002396 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 309799002397 Walker A/P-loop; other site 309799002398 ATP binding site [chemical binding]; other site 309799002399 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; pfam06470 309799002400 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 309799002401 ABC transporter signature motif; other site 309799002402 Walker B; other site 309799002403 D-loop; other site 309799002404 H-loop/switch region; other site 309799002405 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 309799002406 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 309799002407 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 309799002408 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 309799002409 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 309799002410 Coenzyme A binding pocket [chemical binding]; other site 309799002411 lipoprotein signal peptidase; Provisional; Region: PRK14787 309799002412 Signal peptidase (SPase) II; Region: Peptidase_A8; pfam01252 309799002413 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 309799002414 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 309799002415 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 309799002416 ATP-grasp domain; Region: ATP-grasp_4; cl17255 309799002417 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 309799002418 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 309799002419 RNA binding surface [nucleotide binding]; other site 309799002420 Ribosomal protein L11 methylase [Translation, ribosomal structure and biogenesis]; Region: PrmA; COG2264 309799002421 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 309799002422 S-adenosylmethionine binding site [chemical binding]; other site 309799002423 Protein of unknown function (DUF1284); Region: DUF1284; cl01419 309799002424 agmatinase; Region: agmatinase; TIGR01230 309799002425 Uncharacterized conserved protein [Function unknown]; Region: COG1479 309799002426 Protein of unknown function DUF262; Region: DUF262; pfam03235 309799002427 Protein of unknown function DUF262; Region: DUF262; pfam03235 309799002428 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 309799002429 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 309799002430 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 309799002431 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 309799002432 ring oligomerisation interface [polypeptide binding]; other site 309799002433 ATP/Mg binding site [chemical binding]; other site 309799002434 stacking interactions; other site 309799002435 hinge regions; other site 309799002436 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 309799002437 oligomerisation interface [polypeptide binding]; other site 309799002438 mobile loop; other site 309799002439 roof hairpin; other site 309799002440 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 309799002441 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 309799002442 putative ADP-binding pocket [chemical binding]; other site 309799002443 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 309799002444 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 309799002445 Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219 309799002446 UGMP family protein; Validated; Region: PRK09604 309799002447 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 309799002448 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 309799002449 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 309799002450 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 309799002451 Coenzyme A binding pocket [chemical binding]; other site 309799002452 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 309799002453 Glycoprotease family; Region: Peptidase_M22; pfam00814 309799002454 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 309799002455 AAA domain; Region: AAA_25; pfam13481 309799002456 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 309799002457 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 309799002458 GDP-binding site [chemical binding]; other site 309799002459 ACT binding site; other site 309799002460 IMP binding site; other site 309799002461 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 309799002462 Malic enzyme, N-terminal domain; Region: malic; pfam00390 309799002463 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 309799002464 putative NAD(P) binding site [chemical binding]; other site 309799002465 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 309799002466 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 309799002467 dimer interface [polypeptide binding]; other site 309799002468 anticodon binding site; other site 309799002469 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 309799002470 homodimer interface [polypeptide binding]; other site 309799002471 motif 1; other site 309799002472 active site 309799002473 motif 2; other site 309799002474 GAD domain; Region: GAD; pfam02938 309799002475 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 309799002476 motif 3; other site 309799002477 histidyl-tRNA synthetase; Region: hisS; TIGR00442 309799002478 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 309799002479 dimer interface [polypeptide binding]; other site 309799002480 motif 1; other site 309799002481 active site 309799002482 motif 2; other site 309799002483 motif 3; other site 309799002484 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 309799002485 anticodon binding site; other site 309799002486 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 309799002487 putative active site [active] 309799002488 dimerization interface [polypeptide binding]; other site 309799002489 putative tRNAtyr binding site [nucleotide binding]; other site 309799002490 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 309799002491 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 309799002492 Zn2+ binding site [ion binding]; other site 309799002493 Mg2+ binding site [ion binding]; other site 309799002494 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 309799002495 synthetase active site [active] 309799002496 NTP binding site [chemical binding]; other site 309799002497 metal binding site [ion binding]; metal-binding site 309799002498 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 309799002499 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 309799002500 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 309799002501 putative substrate translocation pore; other site 309799002502 Major Facilitator Superfamily; Region: MFS_1; pfam07690 309799002503 Predicted membrane protein [Function unknown]; Region: COG2119 309799002504 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 309799002505 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 309799002506 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 309799002507 RPB12 interaction site [polypeptide binding]; other site 309799002508 RPB1 interaction site [polypeptide binding]; other site 309799002509 RPB10 interaction site [polypeptide binding]; other site 309799002510 RPB11 interaction site [polypeptide binding]; other site 309799002511 RPB3 interaction site [polypeptide binding]; other site 309799002512 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 309799002513 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 309799002514 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 309799002515 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 309799002516 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 309799002517 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 309799002518 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 309799002519 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 309799002520 Apocytochrome F, C-terminal; Region: Apocytochr_F_C; cl03168 309799002521 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 309799002522 DNA binding site [nucleotide binding] 309799002523 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 309799002524 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 309799002525 S17 interaction site [polypeptide binding]; other site 309799002526 S8 interaction site; other site 309799002527 16S rRNA interaction site [nucleotide binding]; other site 309799002528 streptomycin interaction site [chemical binding]; other site 309799002529 23S rRNA interaction site [nucleotide binding]; other site 309799002530 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 309799002531 30S ribosomal protein S7; Validated; Region: PRK05302 309799002532 elongation factor G; Reviewed; Region: PRK00007 309799002533 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 309799002534 G1 box; other site 309799002535 putative GEF interaction site [polypeptide binding]; other site 309799002536 GTP/Mg2+ binding site [chemical binding]; other site 309799002537 Switch I region; other site 309799002538 G2 box; other site 309799002539 G3 box; other site 309799002540 Switch II region; other site 309799002541 G4 box; other site 309799002542 G5 box; other site 309799002543 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 309799002544 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 309799002545 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 309799002546 elongation factor Tu; Reviewed; Region: PRK00049 309799002547 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 309799002548 G1 box; other site 309799002549 GEF interaction site [polypeptide binding]; other site 309799002550 GTP/Mg2+ binding site [chemical binding]; other site 309799002551 Switch I region; other site 309799002552 G2 box; other site 309799002553 G3 box; other site 309799002554 Switch II region; other site 309799002555 G4 box; other site 309799002556 G5 box; other site 309799002557 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 309799002558 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 309799002559 Antibiotic Binding Site [chemical binding]; other site 309799002560 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 309799002561 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 309799002562 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 309799002563 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 309799002564 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 309799002565 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 309799002566 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 309799002567 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 309799002568 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 309799002569 putative translocon binding site; other site 309799002570 protein-rRNA interface [nucleotide binding]; other site 309799002571 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 309799002572 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 309799002573 G-X-X-G motif; other site 309799002574 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 309799002575 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 309799002576 23S rRNA interface [nucleotide binding]; other site 309799002577 5S rRNA interface [nucleotide binding]; other site 309799002578 putative antibiotic binding site [chemical binding]; other site 309799002579 L25 interface [polypeptide binding]; other site 309799002580 L27 interface [polypeptide binding]; other site 309799002581 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 309799002582 23S rRNA interface [nucleotide binding]; other site 309799002583 putative translocon interaction site; other site 309799002584 signal recognition particle (SRP54) interaction site; other site 309799002585 L23 interface [polypeptide binding]; other site 309799002586 trigger factor interaction site; other site 309799002587 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 309799002588 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 309799002589 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 309799002590 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 309799002591 RNA binding site [nucleotide binding]; other site 309799002592 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 309799002593 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 309799002594 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 309799002595 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 309799002596 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 309799002597 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 309799002598 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 309799002599 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 309799002600 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 309799002601 5S rRNA interface [nucleotide binding]; other site 309799002602 23S rRNA interface [nucleotide binding]; other site 309799002603 L5 interface [polypeptide binding]; other site 309799002604 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 309799002605 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 309799002606 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 309799002607 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 309799002608 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 309799002609 SecY translocase; Region: SecY; pfam00344 309799002610 adenylate kinase; Reviewed; Region: adk; PRK00279 309799002611 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 309799002612 AMP-binding site [chemical binding]; other site 309799002613 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 309799002614 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 309799002615 active site 309799002616 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 309799002617 rRNA binding site [nucleotide binding]; other site 309799002618 predicted 30S ribosome binding site; other site 309799002619 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 309799002620 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 309799002621 30S ribosomal protein S13; Region: bact_S13; TIGR03631 309799002622 30S ribosomal protein S11; Validated; Region: PRK05309 309799002623 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 309799002624 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 309799002625 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 309799002626 RNA binding surface [nucleotide binding]; other site 309799002627 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 309799002628 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 309799002629 alphaNTD homodimer interface [polypeptide binding]; other site 309799002630 alphaNTD - beta interaction site [polypeptide binding]; other site 309799002631 alphaNTD - beta' interaction site [polypeptide binding]; other site 309799002632 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 309799002633 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 309799002634 cobalt transporter ATP-binding subunit; Provisional; Region: PRK13633 309799002635 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 309799002636 Walker A/P-loop; other site 309799002637 ATP binding site [chemical binding]; other site 309799002638 Q-loop/lid; other site 309799002639 ABC transporter signature motif; other site 309799002640 Walker B; other site 309799002641 D-loop; other site 309799002642 H-loop/switch region; other site 309799002643 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13637 309799002644 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 309799002645 Walker A/P-loop; other site 309799002646 ATP binding site [chemical binding]; other site 309799002647 Q-loop/lid; other site 309799002648 ABC transporter signature motif; other site 309799002649 Walker B; other site 309799002650 D-loop; other site 309799002651 H-loop/switch region; other site 309799002652 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 309799002653 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 309799002654 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 309799002655 dimerization interface 3.5A [polypeptide binding]; other site 309799002656 active site 309799002657 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 309799002658 23S rRNA interface [nucleotide binding]; other site 309799002659 L3 interface [polypeptide binding]; other site 309799002660 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 309799002661 AmmeMemoRadiSam system protein A; Region: AmmeMemoSam_A; TIGR04335 309799002662 AMMECR1; Region: AMMECR1; pfam01871 309799002663 AmmeMemoRadiSam system radical SAM enzyme; Region: AmmeMemoSam_rS; TIGR04337 309799002664 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 309799002665 FeS/SAM binding site; other site 309799002666 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 309799002667 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 309799002668 active site 309799002669 substrate binding site [chemical binding]; other site 309799002670 metal binding site [ion binding]; metal-binding site 309799002671 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 309799002672 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 309799002673 glutaminase active site [active] 309799002674 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 309799002675 dimer interface [polypeptide binding]; other site 309799002676 active site 309799002677 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 309799002678 dimer interface [polypeptide binding]; other site 309799002679 active site 309799002680 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 309799002681 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 309799002682 binding surface 309799002683 TPR motif; other site 309799002684 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 309799002685 binding surface 309799002686 Tetratricopeptide repeat; Region: TPR_16; pfam13432 309799002687 TPR motif; other site 309799002688 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 309799002689 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 309799002690 motif 1; other site 309799002691 active site 309799002692 motif 2; other site 309799002693 motif 3; other site 309799002694 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 309799002695 DHHA1 domain; Region: DHHA1; pfam02272 309799002696 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 309799002697 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 309799002698 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 309799002699 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 309799002700 active site 309799002701 dimer interface [polypeptide binding]; other site 309799002702 motif 1; other site 309799002703 motif 2; other site 309799002704 motif 3; other site 309799002705 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 309799002706 anticodon binding site; other site 309799002707 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 309799002708 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 309799002709 Protein of unknown function (DUF342); Region: DUF342; pfam03961 309799002710 type IV pilus assembly protein PilM; Region: pilM; TIGR01175 309799002711 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 309799002712 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 309799002713 Pilus assembly protein, PilO; Region: PilO; cl01234 309799002714 Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356 309799002715 AMIN domain; Region: AMIN; pfam11741 309799002716 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 309799002717 type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515 309799002718 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 309799002719 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 309799002720 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 309799002721 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 309799002722 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 309799002723 active site 309799002724 elongation factor P; Validated; Region: PRK00529 309799002725 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 309799002726 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 309799002727 RNA binding site [nucleotide binding]; other site 309799002728 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 309799002729 RNA binding site [nucleotide binding]; other site 309799002730 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 309799002731 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 309799002732 carboxyltransferase (CT) interaction site; other site 309799002733 biotinylation site [posttranslational modification]; other site 309799002734 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 309799002735 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 309799002736 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 309799002737 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 309799002738 Asp23 family; Region: Asp23; pfam03780 309799002739 transcription antitermination factor NusB; Region: nusB; TIGR01951 309799002740 putative RNA binding site [nucleotide binding]; other site 309799002741 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 309799002742 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 309799002743 TPP-binding site; other site 309799002744 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 309799002745 PYR/PP interface [polypeptide binding]; other site 309799002746 dimer interface [polypeptide binding]; other site 309799002747 TPP binding site [chemical binding]; other site 309799002748 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 309799002749 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 309799002750 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 309799002751 RNA binding surface [nucleotide binding]; other site 309799002752 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 309799002753 S-adenosylmethionine binding site [chemical binding]; other site 309799002754 NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061 309799002755 ATP-NAD kinase; Region: NAD_kinase; pfam01513 309799002756 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 309799002757 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 309799002758 Walker A/P-loop; other site 309799002759 ATP binding site [chemical binding]; other site 309799002760 Q-loop/lid; other site 309799002761 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 309799002762 ABC transporter signature motif; other site 309799002763 Walker B; other site 309799002764 D-loop; other site 309799002765 H-loop/switch region; other site 309799002766 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 309799002767 dimer interface [polypeptide binding]; other site 309799002768 ADP-ribose binding site [chemical binding]; other site 309799002769 active site 309799002770 nudix motif; other site 309799002771 metal binding site [ion binding]; metal-binding site 309799002772 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 309799002773 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 309799002774 hexamer interface [polypeptide binding]; other site 309799002775 ligand binding site [chemical binding]; other site 309799002776 putative active site [active] 309799002777 NAD(P) binding site [chemical binding]; other site 309799002778 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 309799002779 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 309799002780 dimerization interface [polypeptide binding]; other site 309799002781 domain crossover interface; other site 309799002782 redox-dependent activation switch; other site 309799002783 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 309799002784 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 309799002785 substrate binding pocket [chemical binding]; other site 309799002786 membrane-bound complex binding site; other site 309799002787 hinge residues; other site 309799002788 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 309799002789 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 309799002790 dimer interface [polypeptide binding]; other site 309799002791 conserved gate region; other site 309799002792 putative PBP binding loops; other site 309799002793 ABC-ATPase subunit interface; other site 309799002794 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 309799002795 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 309799002796 Walker A/P-loop; other site 309799002797 ATP binding site [chemical binding]; other site 309799002798 Q-loop/lid; other site 309799002799 ABC transporter signature motif; other site 309799002800 Walker B; other site 309799002801 D-loop; other site 309799002802 H-loop/switch region; other site 309799002803 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 309799002804 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 309799002805 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 309799002806 NAD(P) binding site [chemical binding]; other site 309799002807 shikimate binding site; other site 309799002808 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 309799002809 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 309799002810 Tetramer interface [polypeptide binding]; other site 309799002811 active site 309799002812 FMN-binding site [chemical binding]; other site 309799002813 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 309799002814 active site 309799002815 dimer interface [polypeptide binding]; other site 309799002816 metal binding site [ion binding]; metal-binding site 309799002817 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 309799002818 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 309799002819 prephenate dehydrogenase; Validated; Region: PRK08507 309799002820 Prephenate dehydrogenase; Region: PDH; pfam02153 309799002821 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 309799002822 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 309799002823 hinge; other site 309799002824 active site 309799002825 Trp repressor protein; Region: Trp_repressor; cl17266 309799002826 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 309799002827 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 309799002828 Walker A/P-loop; other site 309799002829 ATP binding site [chemical binding]; other site 309799002830 Q-loop/lid; other site 309799002831 ABC transporter signature motif; other site 309799002832 Walker B; other site 309799002833 D-loop; other site 309799002834 H-loop/switch region; other site 309799002835 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 309799002836 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 309799002837 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 309799002838 Walker A/P-loop; other site 309799002839 ATP binding site [chemical binding]; other site 309799002840 Q-loop/lid; other site 309799002841 ABC transporter signature motif; other site 309799002842 Walker B; other site 309799002843 D-loop; other site 309799002844 H-loop/switch region; other site 309799002845 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 309799002846 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 309799002847 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 309799002848 dimer interface [polypeptide binding]; other site 309799002849 conserved gate region; other site 309799002850 putative PBP binding loops; other site 309799002851 ABC-ATPase subunit interface; other site 309799002852 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 309799002853 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 309799002854 putative PBP binding loops; other site 309799002855 dimer interface [polypeptide binding]; other site 309799002856 ABC-ATPase subunit interface; other site 309799002857 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 309799002858 Predicted solute binding protein [General function prediction only]; Region: COG3889 309799002859 ferredoxin-NADP(+) reductase subunit alpha; Reviewed; Region: PRK06222 309799002860 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)...; Region: DHOD_e_trans_like1; cd06219 309799002861 FAD binding pocket [chemical binding]; other site 309799002862 FAD binding motif [chemical binding]; other site 309799002863 phosphate binding motif [ion binding]; other site 309799002864 beta-alpha-beta structure motif; other site 309799002865 NAD binding pocket [chemical binding]; other site 309799002866 Iron coordination center [ion binding]; other site 309799002867 putative oxidoreductase; Provisional; Region: PRK12831 309799002868 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 309799002869 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 309799002870 putative homodimer interface [polypeptide binding]; other site 309799002871 putative homotetramer interface [polypeptide binding]; other site 309799002872 putative allosteric switch controlling residues; other site 309799002873 putative metal binding site [ion binding]; other site 309799002874 putative homodimer-homodimer interface [polypeptide binding]; other site 309799002875 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 309799002876 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 309799002877 L-aspartate oxidase; Provisional; Region: PRK06175 309799002878 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 309799002879 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 309799002880 active site 309799002881 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 309799002882 metal binding site 2 [ion binding]; metal-binding site 309799002883 putative DNA binding helix; other site 309799002884 metal binding site 1 [ion binding]; metal-binding site 309799002885 dimer interface [polypeptide binding]; other site 309799002886 structural Zn2+ binding site [ion binding]; other site 309799002887 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 309799002888 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 309799002889 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 309799002890 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 309799002891 Histidine kinase; Region: HisKA_2; pfam07568 309799002892 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14328 309799002893 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 309799002894 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 309799002895 FeS/SAM binding site; other site 309799002896 TRAM domain; Region: TRAM; pfam01938 309799002897 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 309799002898 MutS domain I; Region: MutS_I; pfam01624 309799002899 MutS domain II; Region: MutS_II; pfam05188 309799002900 MutS domain III; Region: MutS_III; pfam05192 309799002901 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 309799002902 Walker A/P-loop; other site 309799002903 ATP binding site [chemical binding]; other site 309799002904 Q-loop/lid; other site 309799002905 ABC transporter signature motif; other site 309799002906 Walker B; other site 309799002907 D-loop; other site 309799002908 H-loop/switch region; other site 309799002909 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 309799002910 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 309799002911 ATP binding site [chemical binding]; other site 309799002912 Mg2+ binding site [ion binding]; other site 309799002913 G-X-G motif; other site 309799002914 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 309799002915 ATP binding site [chemical binding]; other site 309799002916 MutL C terminal dimerisation domain; Region: MutL_C; smart00853 309799002917 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 309799002918 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 309799002919 LL-diaminopimelate aminotransferase; Region: DapC_direct; TIGR03540 309799002920 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 309799002921 pyridoxal 5'-phosphate binding site [chemical binding]; other site 309799002922 homodimer interface [polypeptide binding]; other site 309799002923 catalytic residue [active] 309799002924 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 309799002925 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 309799002926 HflX GTPase family; Region: HflX; cd01878 309799002927 G1 box; other site 309799002928 GTP/Mg2+ binding site [chemical binding]; other site 309799002929 Switch I region; other site 309799002930 G2 box; other site 309799002931 G3 box; other site 309799002932 Switch II region; other site 309799002933 G4 box; other site 309799002934 G5 box; other site 309799002935 Protein of unknown function DUF72; Region: DUF72; pfam01904 309799002936 transcription termination factor Rho; Provisional; Region: rho; PRK09376 309799002937 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 309799002938 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 309799002939 RNA binding site [nucleotide binding]; other site 309799002940 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 309799002941 multimer interface [polypeptide binding]; other site 309799002942 Walker A motif; other site 309799002943 ATP binding site [chemical binding]; other site 309799002944 Walker B motif; other site 309799002945 Sporulation and spore germination; Region: Germane; pfam10646 309799002946 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 309799002947 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 309799002948 active site 309799002949 metal binding site [ion binding]; metal-binding site 309799002950 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 309799002951 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 309799002952 active site 309799002953 metal binding site [ion binding]; metal-binding site 309799002954 homotetramer interface [polypeptide binding]; other site 309799002955 trigger factor; Region: tig; TIGR00115 309799002956 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 309799002957 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 309799002958 Clp protease; Region: CLP_protease; pfam00574 309799002959 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 309799002960 oligomer interface [polypeptide binding]; other site 309799002961 active site residues [active] 309799002962 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 309799002963 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 309799002964 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 309799002965 Walker A motif; other site 309799002966 ATP binding site [chemical binding]; other site 309799002967 Walker B motif; other site 309799002968 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 309799002969 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 309799002970 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 309799002971 HIGH motif; other site 309799002972 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 309799002973 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 309799002974 active site 309799002975 KMSKS motif; other site 309799002976 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 309799002977 anticodon binding site; other site 309799002978 tRNA binding surface [nucleotide binding]; other site 309799002979 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 309799002980 electron transport complex, RnfABCDGE type, C subunit; Region: rnfC; TIGR01945 309799002981 SLBB domain; Region: SLBB; pfam10531 309799002982 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; pfam03116 309799002983 FMN-binding domain; Region: FMN_bind; cl01081 309799002984 electron transport complex RsxE subunit; Provisional; Region: PRK12405 309799002985 Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597 309799002986 ferredoxin; Provisional; Region: PRK08764 309799002987 Putative Fe-S cluster; Region: FeS; cl17515 309799002988 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 309799002989 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 309799002990 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 309799002991 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 309799002992 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 309799002993 ApbE family; Region: ApbE; pfam02424 309799002994 Heptaprenyl diphosphate synthase component I; Region: Hpre_diP_synt_I; pfam07456 309799002995 Domain of unknown function (DUF4321); Region: DUF4321; pfam14209 309799002996 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 309799002997 Calmodulin-binding; Region: Enkurin; pfam13864 309799002998 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 309799002999 Peptidase family M23; Region: Peptidase_M23; pfam01551 309799003000 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 309799003001 C-terminal peptidase (prc); Region: prc; TIGR00225 309799003002 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 309799003003 protein binding site [polypeptide binding]; other site 309799003004 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 309799003005 Catalytic dyad [active] 309799003006 SLBB domain; Region: SLBB; pfam10531 309799003007 comEA protein; Region: comE; TIGR01259 309799003008 Helix-hairpin-helix motif; Region: HHH; pfam00633 309799003009 Competence protein; Region: Competence; pfam03772 309799003010 DNA polymerase III, delta subunit [DNA replication, recombination, and repair]; Region: HolA; COG1466 309799003011 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 309799003012 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 309799003013 GTP-binding protein LepA; Provisional; Region: PRK05433 309799003014 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 309799003015 G1 box; other site 309799003016 putative GEF interaction site [polypeptide binding]; other site 309799003017 GTP/Mg2+ binding site [chemical binding]; other site 309799003018 Switch I region; other site 309799003019 G2 box; other site 309799003020 G3 box; other site 309799003021 Switch II region; other site 309799003022 G4 box; other site 309799003023 G5 box; other site 309799003024 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 309799003025 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 309799003026 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 309799003027 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 309799003028 Coproporphyrinogen III oxidase and related Fe-S oxidoreductases [Coenzyme metabolism]; Region: HemN; COG0635 309799003029 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 309799003030 FeS/SAM binding site; other site 309799003031 HemN C-terminal domain; Region: HemN_C; pfam06969 309799003032 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 309799003033 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 309799003034 active site 309799003035 phosphorylation site [posttranslational modification] 309799003036 intermolecular recognition site; other site 309799003037 dimerization interface [polypeptide binding]; other site 309799003038 ANTAR domain; Region: ANTAR; pfam03861 309799003039 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 309799003040 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 309799003041 Mg++ binding site [ion binding]; other site 309799003042 putative catalytic motif [active] 309799003043 substrate binding site [chemical binding]; other site 309799003044 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 309799003045 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 309799003046 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 309799003047 Methyltransferase domain; Region: Methyltransf_23; pfam13489 309799003048 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 309799003049 S-adenosylmethionine binding site [chemical binding]; other site 309799003050 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 309799003051 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 309799003052 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 309799003053 nucleotide binding site [chemical binding]; other site 309799003054 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 309799003055 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 309799003056 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 309799003057 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 309799003058 ATP phosphoribosyltransferase, regulatory subunit; Region: hisZ_biosyn_reg; TIGR00443 309799003059 motif 1; other site 309799003060 dimer interface [polypeptide binding]; other site 309799003061 active site 309799003062 motif 2; other site 309799003063 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 309799003064 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 309799003065 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 309799003066 histidinol dehydrogenase; Region: hisD; TIGR00069 309799003067 NAD binding site [chemical binding]; other site 309799003068 dimerization interface [polypeptide binding]; other site 309799003069 product binding site; other site 309799003070 substrate binding site [chemical binding]; other site 309799003071 zinc binding site [ion binding]; other site 309799003072 catalytic residues [active] 309799003073 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 309799003074 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 309799003075 pyridoxal 5'-phosphate binding site [chemical binding]; other site 309799003076 homodimer interface [polypeptide binding]; other site 309799003077 catalytic residue [active] 309799003078 imidazoleglycerol-phosphate dehydratase; Validated; Region: hisB; PRK00951 309799003079 putative active site pocket [active] 309799003080 4-fold oligomerization interface [polypeptide binding]; other site 309799003081 metal binding residues [ion binding]; metal-binding site 309799003082 3-fold/trimer interface [polypeptide binding]; other site 309799003083 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 309799003084 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 309799003085 putative active site [active] 309799003086 oxyanion strand; other site 309799003087 catalytic triad [active] 309799003088 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 309799003089 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 309799003090 catalytic residues [active] 309799003091 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 309799003092 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 309799003093 substrate binding site [chemical binding]; other site 309799003094 glutamase interaction surface [polypeptide binding]; other site 309799003095 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 309799003096 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 309799003097 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 309799003098 metal binding site [ion binding]; metal-binding site 309799003099 Transglycosylase; Region: Transgly; pfam00912 309799003100 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 309799003101 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 309799003102 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 309799003103 AAA domain; Region: AAA_33; pfam13671 309799003104 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 309799003105 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 309799003106 phosphate binding site [ion binding]; other site 309799003107 putative substrate binding pocket [chemical binding]; other site 309799003108 dimer interface [polypeptide binding]; other site 309799003109 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 309799003110 Phosphoglycerate kinase; Region: PGK; pfam00162 309799003111 substrate binding site [chemical binding]; other site 309799003112 hinge regions; other site 309799003113 ADP binding site [chemical binding]; other site 309799003114 catalytic site [active] 309799003115 Roadblock/LC7 domain; Region: Robl_LC7; smart00960 309799003116 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 309799003117 triosephosphate isomerase; Provisional; Region: PRK14565 309799003118 substrate binding site [chemical binding]; other site 309799003119 dimer interface [polypeptide binding]; other site 309799003120 catalytic triad [active] 309799003121 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 309799003122 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 309799003123 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 309799003124 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 309799003125 dimer interface [polypeptide binding]; other site 309799003126 conserved gate region; other site 309799003127 putative PBP binding loops; other site 309799003128 ABC-ATPase subunit interface; other site 309799003129 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 309799003130 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 309799003131 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 309799003132 dimer interface [polypeptide binding]; other site 309799003133 conserved gate region; other site 309799003134 putative PBP binding loops; other site 309799003135 ABC-ATPase subunit interface; other site 309799003136 Asp23 family; Region: Asp23; pfam03780 309799003137 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 309799003138 DAK2 domain; Region: Dak2; pfam02734 309799003139 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 309799003140 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 309799003141 generic binding surface II; other site 309799003142 ssDNA binding site; other site 309799003143 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 309799003144 ATP binding site [chemical binding]; other site 309799003145 putative Mg++ binding site [ion binding]; other site 309799003146 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 309799003147 nucleotide binding region [chemical binding]; other site 309799003148 ATP-binding site [chemical binding]; other site 309799003149 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 309799003150 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 309799003151 S-adenosylmethionine binding site [chemical binding]; other site 309799003152 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 309799003153 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 309799003154 active site 309799003155 (T/H)XGH motif; other site 309799003156 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 309799003157 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 309799003158 16S/18S rRNA binding site [nucleotide binding]; other site 309799003159 S13e-L30e interaction site [polypeptide binding]; other site 309799003160 25S rRNA binding site [nucleotide binding]; other site 309799003161 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 309799003162 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 309799003163 RNase E interface [polypeptide binding]; other site 309799003164 trimer interface [polypeptide binding]; other site 309799003165 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 309799003166 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 309799003167 RNase E interface [polypeptide binding]; other site 309799003168 trimer interface [polypeptide binding]; other site 309799003169 active site 309799003170 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 309799003171 putative nucleic acid binding region [nucleotide binding]; other site 309799003172 G-X-X-G motif; other site 309799003173 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 309799003174 RNA binding site [nucleotide binding]; other site 309799003175 domain interface; other site 309799003176 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 309799003177 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 309799003178 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 309799003179 dihydrodipicolinate reductase; Provisional; Region: PRK00048 309799003180 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 309799003181 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 309799003182 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 309799003183 dihydrodipicolinate synthase; Region: dapA; TIGR00674 309799003184 dimer interface [polypeptide binding]; other site 309799003185 active site 309799003186 catalytic residue [active] 309799003187 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 309799003188 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 309799003189 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 309799003190 Protein of unknown function (DUF3561); Region: DUF3561; cl08142 309799003191 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 309799003192 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 309799003193 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 309799003194 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 309799003195 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 309799003196 ligand binding site [chemical binding]; other site 309799003197 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 309799003198 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 309799003199 Walker A/P-loop; other site 309799003200 ATP binding site [chemical binding]; other site 309799003201 Q-loop/lid; other site 309799003202 ABC transporter signature motif; other site 309799003203 Walker B; other site 309799003204 D-loop; other site 309799003205 H-loop/switch region; other site 309799003206 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 309799003207 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 309799003208 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 309799003209 TM-ABC transporter signature motif; other site 309799003210 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 309799003211 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 309799003212 TM-ABC transporter signature motif; other site 309799003213 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 309799003214 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 309799003215 putative acyl-acceptor binding pocket; other site 309799003216 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 309799003217 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 309799003218 putative acyl-acceptor binding pocket; other site 309799003219 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 309799003220 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 309799003221 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 309799003222 G3 box; other site 309799003223 Switch II region; other site 309799003224 GTP/Mg2+ binding site [chemical binding]; other site 309799003225 G4 box; other site 309799003226 G5 box; other site 309799003227 Elongation factor Tu GTP binding domain; Region: GTP_EFTU; pfam00009 309799003228 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 309799003229 G1 box; other site 309799003230 GTP/Mg2+ binding site [chemical binding]; other site 309799003231 Switch I region; other site 309799003232 G2 box; other site 309799003233 G3 box; other site 309799003234 Switch II region; other site 309799003235 G4 box; other site 309799003236 G5 box; other site 309799003237 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 309799003238 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 309799003239 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 309799003240 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 309799003241 recombinase A; Provisional; Region: recA; PRK09354 309799003242 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 309799003243 hexamer interface [polypeptide binding]; other site 309799003244 Walker A motif; other site 309799003245 ATP binding site [chemical binding]; other site 309799003246 Walker B motif; other site 309799003247 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 309799003248 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 309799003249 Walker A/P-loop; other site 309799003250 ATP binding site [chemical binding]; other site 309799003251 Q-loop/lid; other site 309799003252 ABC transporter signature motif; other site 309799003253 Walker B; other site 309799003254 D-loop; other site 309799003255 H-loop/switch region; other site 309799003256 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 309799003257 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 309799003258 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 309799003259 Walker A/P-loop; other site 309799003260 ATP binding site [chemical binding]; other site 309799003261 Q-loop/lid; other site 309799003262 ABC transporter signature motif; other site 309799003263 Walker B; other site 309799003264 D-loop; other site 309799003265 H-loop/switch region; other site 309799003266 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 309799003267 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 309799003268 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 309799003269 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 309799003270 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 309799003271 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 309799003272 GatB domain; Region: GatB_Yqey; smart00845 309799003273 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 309799003274 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 309799003275 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 309799003276 Walker A motif; other site 309799003277 ATP binding site [chemical binding]; other site 309799003278 Walker B motif; other site 309799003279 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 309799003280 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 309799003281 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 309799003282 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 309799003283 Lamin Tail Domain; Region: LTD; pfam00932 309799003284 Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972 309799003285 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 309799003286 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 309799003287 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 309799003288 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 309799003289 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 309799003290 acetolactate synthase 3 catalytic subunit; Reviewed; Region: PRK06048 309799003291 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 309799003292 PYR/PP interface [polypeptide binding]; other site 309799003293 dimer interface [polypeptide binding]; other site 309799003294 TPP binding site [chemical binding]; other site 309799003295 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 309799003296 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 309799003297 TPP-binding site [chemical binding]; other site 309799003298 dimer interface [polypeptide binding]; other site 309799003299 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 309799003300 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 309799003301 putative valine binding site [chemical binding]; other site 309799003302 dimer interface [polypeptide binding]; other site 309799003303 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 309799003304 ketol-acid reductoisomerase; Provisional; Region: PRK05479 309799003305 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 309799003306 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 309799003307 2-isopropylmalate synthase; Validated; Region: PRK00915 309799003308 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 309799003309 active site 309799003310 catalytic residues [active] 309799003311 metal binding site [ion binding]; metal-binding site 309799003312 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 309799003313 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 309799003314 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 309799003315 substrate binding site [chemical binding]; other site 309799003316 ligand binding site [chemical binding]; other site 309799003317 3-isopropylmalate dehydratase small subunit; Reviewed; Region: leuD; PRK00439 309799003318 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 309799003319 substrate binding site [chemical binding]; other site 309799003320 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 309799003321 tartrate dehydrogenase; Region: TTC; TIGR02089 309799003322 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 309799003323 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 309799003324 active site 309799003325 catalytic residues [active] 309799003326 metal binding site [ion binding]; metal-binding site 309799003327 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 309799003328 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 309799003329 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 309799003330 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 309799003331 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 309799003332 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 309799003333 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 309799003334 dimer interface [polypeptide binding]; other site 309799003335 active site 309799003336 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 309799003337 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 309799003338 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 309799003339 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 309799003340 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 309799003341 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 309799003342 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 309799003343 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 309799003344 catalytic residue [active] 309799003345 putative FPP diphosphate binding site; other site 309799003346 putative FPP binding hydrophobic cleft; other site 309799003347 dimer interface [polypeptide binding]; other site 309799003348 putative IPP diphosphate binding site; other site 309799003349 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 309799003350 ribosome recycling factor; Reviewed; Region: frr; PRK00083 309799003351 hinge region; other site 309799003352 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 309799003353 putative nucleotide binding site [chemical binding]; other site 309799003354 uridine monophosphate binding site [chemical binding]; other site 309799003355 homohexameric interface [polypeptide binding]; other site 309799003356 elongation factor Ts; Reviewed; Region: tsf; PRK12332 309799003357 UBA/TS-N domain; Region: UBA; pfam00627 309799003358 Elongation factor TS; Region: EF_TS; pfam00889 309799003359 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 309799003360 rRNA interaction site [nucleotide binding]; other site 309799003361 S8 interaction site; other site 309799003362 putative laminin-1 binding site; other site 309799003363 ribosome maturation protein RimP; Reviewed; Region: PRK00092 309799003364 Sm and related proteins; Region: Sm_like; cl00259 309799003365 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 309799003366 putative oligomer interface [polypeptide binding]; other site 309799003367 putative RNA binding site [nucleotide binding]; other site 309799003368 NusA N-terminal domain; Region: NusA_N; pfam08529 309799003369 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 309799003370 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 309799003371 RNA binding site [nucleotide binding]; other site 309799003372 homodimer interface [polypeptide binding]; other site 309799003373 NusA-like KH domain; Region: KH_5; pfam13184 309799003374 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 309799003375 G-X-X-G motif; other site 309799003376 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 309799003377 putative RNA binding cleft [nucleotide binding]; other site 309799003378 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 309799003379 translation initiation factor IF-2; Region: IF-2; TIGR00487 309799003380 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 309799003381 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 309799003382 G1 box; other site 309799003383 putative GEF interaction site [polypeptide binding]; other site 309799003384 GTP/Mg2+ binding site [chemical binding]; other site 309799003385 Switch I region; other site 309799003386 G2 box; other site 309799003387 G3 box; other site 309799003388 Switch II region; other site 309799003389 G4 box; other site 309799003390 G5 box; other site 309799003391 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 309799003392 Translation-initiation factor 2; Region: IF-2; pfam11987 309799003393 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 309799003394 Protein of unknown function (DUF503); Region: DUF503; pfam04456 309799003395 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 309799003396 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 309799003397 DHH family; Region: DHH; pfam01368 309799003398 DHHA1 domain; Region: DHHA1; pfam02272 309799003399 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK00130 309799003400 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 309799003401 RNA binding site [nucleotide binding]; other site 309799003402 active site 309799003403 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 309799003404 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 309799003405 active site 309799003406 Riboflavin kinase; Region: Flavokinase; pfam01687 309799003407 cytidylate kinase; Provisional; Region: cmk; PRK00023 309799003408 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 309799003409 CMP-binding site; other site 309799003410 The sites determining sugar specificity; other site 309799003411 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 309799003412 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 309799003413 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 309799003414 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 309799003415 active site 309799003416 motif I; other site 309799003417 motif II; other site 309799003418 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 309799003419 Protein of unknown function (DUF3307); Region: DUF3307; pfam11750 309799003420 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 309799003421 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 309799003422 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 309799003423 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 309799003424 Zn2+ binding site [ion binding]; other site 309799003425 Mg2+ binding site [ion binding]; other site 309799003426 CHASE2 domain; Region: CHASE2; pfam05226 309799003427 Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252 309799003428 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 309799003429 cyclase homology domain; Region: CHD; cd07302 309799003430 nucleotidyl binding site; other site 309799003431 metal binding site [ion binding]; metal-binding site 309799003432 dimer interface [polypeptide binding]; other site 309799003433 FecR protein; Region: FecR; pfam04773 309799003434 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 309799003435 nucleotide binding site [chemical binding]; other site 309799003436 Predicted membrane protein [Function unknown]; Region: COG4684 309799003437 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 309799003438 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 309799003439 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 309799003440 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 309799003441 catalytic residues [active] 309799003442 Radical SAM superfamily; Region: Radical_SAM; pfam04055 309799003443 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 309799003444 FeS/SAM binding site; other site 309799003445 radical SAM protein, TatD family-associated; Region: tatD_link_rSAM; TIGR04038 309799003446 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 309799003447 FeS/SAM binding site; other site 309799003448 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 309799003449 active site 309799003450 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 309799003451 nucleoside/Zn binding site; other site 309799003452 dimer interface [polypeptide binding]; other site 309799003453 catalytic motif [active] 309799003454 Uncharacterized protein involved in tolerance to divalent cations [Inorganic ion transport and metabolism]; Region: CutA; COG1324 309799003455 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 309799003456 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 309799003457 active site 309799003458 motif I; other site 309799003459 motif II; other site 309799003460 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 309799003461 radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936 309799003462 Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; cl02090 309799003463 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 309799003464 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 309799003465 B12 binding site [chemical binding]; other site 309799003466 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 309799003467 FeS/SAM binding site; other site 309799003468 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 309799003469 Uncharacterized conserved protein [Function unknown]; Region: COG4198 309799003470 Protein of unknown function (DUF1015); Region: DUF1015; pfam06245 309799003471 PAS domain; Region: PAS; smart00091 309799003472 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 309799003473 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 309799003474 dimer interface [polypeptide binding]; other site 309799003475 phosphorylation site [posttranslational modification] 309799003476 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 309799003477 ATP binding site [chemical binding]; other site 309799003478 Mg2+ binding site [ion binding]; other site 309799003479 G-X-G motif; other site 309799003480 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 309799003481 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 309799003482 active site 309799003483 phosphorylation site [posttranslational modification] 309799003484 intermolecular recognition site; other site 309799003485 dimerization interface [polypeptide binding]; other site 309799003486 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 309799003487 DNA binding site [nucleotide binding] 309799003488 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 309799003489 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 309799003490 catalytic residue [active] 309799003491 Eukaryotic cytochrome b(561); Region: Cyt_b561; cl14616 309799003492 HlyD family secretion protein; Region: HlyD_2; pfam12700 309799003493 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 309799003494 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 309799003495 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 309799003496 B12 binding site [chemical binding]; other site 309799003497 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 309799003498 FeS/SAM binding site; other site 309799003499 cell division protein FtsZ; Validated; Region: PRK09330 309799003500 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 309799003501 nucleotide binding site [chemical binding]; other site 309799003502 SulA interaction site; other site 309799003503 cell division protein FtsA; Region: ftsA; TIGR01174 309799003504 Cell division protein FtsA; Region: FtsA; smart00842 309799003505 Cell division protein FtsA; Region: FtsA; pfam14450 309799003506 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 309799003507 FAD binding domain; Region: FAD_binding_4; pfam01565 309799003508 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 309799003509 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 309799003510 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 309799003511 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 309799003512 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 309799003513 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 309799003514 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 309799003515 active site 309799003516 homodimer interface [polypeptide binding]; other site 309799003517 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 309799003518 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK14106 309799003519 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 309799003520 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 309799003521 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 309799003522 Mg++ binding site [ion binding]; other site 309799003523 putative catalytic motif [active] 309799003524 putative substrate binding site [chemical binding]; other site 309799003525 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 309799003526 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 309799003527 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 309799003528 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 309799003529 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 309799003530 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 309799003531 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 309799003532 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 309799003533 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 309799003534 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 309799003535 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 309799003536 Pyruvate dehydrogenase E1 component subunit alpha; Region: PLN02269 309799003537 MraW methylase family; Region: Methyltransf_5; cl17771 309799003538 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 309799003539 cell division protein MraZ; Reviewed; Region: PRK00326 309799003540 MraZ protein; Region: MraZ; pfam02381 309799003541 MraZ protein; Region: MraZ; pfam02381 309799003542 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 309799003543 Putative zinc ribbon domain; Region: DUF164; pfam02591 309799003544 Short C-terminal domain; Region: SHOCT; pfam09851 309799003545 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 309799003546 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 309799003547 pyridoxal 5'-phosphate binding site [chemical binding]; other site 309799003548 catalytic residue [active] 309799003549 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 309799003550 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 309799003551 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 309799003552 trimer interface [polypeptide binding]; other site 309799003553 active site 309799003554 substrate binding site [chemical binding]; other site 309799003555 CoA binding site [chemical binding]; other site 309799003556 Thiamine transporter protein (Thia_YuaJ); Region: Thia_YuaJ; cl17491 309799003557 CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; cl00663 309799003558 Thiamine transporter protein (Thia_YuaJ); Region: Thia_YuaJ; cl17491 309799003559 Thiamine pyrophosphokinase; Region: TPK; cd07995 309799003560 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 309799003561 active site 309799003562 dimerization interface [polypeptide binding]; other site 309799003563 thiamine binding site [chemical binding]; other site 309799003564 DNA gyrase subunit A; Validated; Region: PRK05560 309799003565 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 309799003566 CAP-like domain; other site 309799003567 active site 309799003568 primary dimer interface [polypeptide binding]; other site 309799003569 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 309799003570 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 309799003571 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 309799003572 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 309799003573 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 309799003574 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 309799003575 Archease protein family (MTH1598/TM1083); Region: Archease; pfam01951 309799003576 GTP-binding protein YchF; Reviewed; Region: PRK09601 309799003577 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 309799003578 G1 box; other site 309799003579 GTP/Mg2+ binding site [chemical binding]; other site 309799003580 Switch I region; other site 309799003581 G3 box; other site 309799003582 Switch II region; other site 309799003583 G4 box; other site 309799003584 G5 box; other site 309799003585 The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information...; Region: TGS; cl15768 309799003586 Predicted transcriptional regulator [Transcription]; Region: COG1959 309799003587 Transcriptional regulator; Region: Rrf2; pfam02082 309799003588 Predicted esterase [General function prediction only]; Region: COG0400 309799003589 PHP family phosphoesterase with a Zn ribbon [General function prediction only]; Region: COG1379 309799003590 PHP-associated; Region: PHP_C; pfam13263 309799003591 ParB-like nuclease domain; Region: ParB; smart00470 309799003592 Domain of unknown function (DUF4032); Region: DUF4032; pfam13224 309799003593 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 309799003594 Thermus thermophilus TTHA0053 and related proteins, metallophosphatase domain; Region: MPP_TTHA0053; cd07403 309799003595 putative active site [active] 309799003596 putative metal binding site [ion binding]; other site 309799003597 Thermus thermophilus TTHA0053 and related proteins, metallophosphatase domain; Region: MPP_TTHA0053; cd07403 309799003598 bifunctional phosphoglucose/phosphomannose isomerase; Validated; Region: PRK08674 309799003599 The members of this protein family contain the SIS (Sugar ISomerase) domain and have both the phosphoglucose isomerase (PGI) and the phosphomannose isomerase (PMI) functions. These functions catalyze the reversible reactions of glucose 6-phosphate to...; Region: SIS_PGI_PMI_1; cd05017 309799003600 dimer interface [polypeptide binding]; other site 309799003601 active site 309799003602 The members of this protein family contain the SIS (Sugar ISomerase) domain and have both the phosphoglucose isomerase (PGI) and the phosphomannose isomerase (PMI) functions. These functions catalyze the reversible reactions of glucose 6-phosphate to...; Region: SIS_PGI_PMI_2; cd05637 309799003603 dimer interface [polypeptide binding]; other site 309799003604 active site 309799003605 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 309799003606 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 309799003607 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 309799003608 active site 309799003609 HIGH motif; other site 309799003610 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 309799003611 active site 309799003612 KMSKS motif; other site 309799003613 YaaC-like Protein; Region: YaaC; pfam14175 309799003614 YaaC-like Protein; Region: YaaC; pfam14175 309799003615 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 309799003616 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 309799003617 substrate binding pocket [chemical binding]; other site 309799003618 chain length determination region; other site 309799003619 substrate-Mg2+ binding site; other site 309799003620 catalytic residues [active] 309799003621 aspartate-rich region 1; other site 309799003622 active site lid residues [active] 309799003623 aspartate-rich region 2; other site 309799003624 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 309799003625 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 309799003626 dimer interface [polypeptide binding]; other site 309799003627 substrate binding site [chemical binding]; other site 309799003628 metal binding site [ion binding]; metal-binding site 309799003629 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 309799003630 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 309799003631 active site 309799003632 (T/H)XGH motif; other site 309799003633 GTPase CgtA; Reviewed; Region: obgE; PRK12297 309799003634 GTP1/OBG; Region: GTP1_OBG; pfam01018 309799003635 Obg GTPase; Region: Obg; cd01898 309799003636 G1 box; other site 309799003637 GTP/Mg2+ binding site [chemical binding]; other site 309799003638 Switch I region; other site 309799003639 G2 box; other site 309799003640 G3 box; other site 309799003641 Switch II region; other site 309799003642 G4 box; other site 309799003643 G5 box; other site 309799003644 Domain of unknown function (DUF1967); Region: DUF1967; cl07779 309799003645 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 309799003646 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 309799003647 Uncharacterized conserved protein [Function unknown]; Region: COG2006 309799003648 Domain of unknown function (DUF362); Region: DUF362; pfam04015 309799003649 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 309799003650 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 309799003651 Positive regulator of sigma(E), RseC/MucC; Region: RseC_MucC; pfam04246 309799003652 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 309799003653 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 309799003654 putative catalytic cysteine [active] 309799003655 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 309799003656 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 309799003657 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 309799003658 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 309799003659 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 309799003660 protein binding site [polypeptide binding]; other site 309799003661 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 309799003662 Predicted permeases [General function prediction only]; Region: COG0795 309799003663 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 309799003664 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 309799003665 MutS domain III; Region: MutS_III; pfam05192 309799003666 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 309799003667 Walker A/P-loop; other site 309799003668 ATP binding site [chemical binding]; other site 309799003669 Q-loop/lid; other site 309799003670 ABC transporter signature motif; other site 309799003671 Walker B; other site 309799003672 D-loop; other site 309799003673 H-loop/switch region; other site 309799003674 Smr domain; Region: Smr; pfam01713 309799003675 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 309799003676 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 309799003677 putative tRNA-binding site [nucleotide binding]; other site 309799003678 B3/4 domain; Region: B3_4; pfam03483 309799003679 tRNA synthetase B5 domain; Region: B5; smart00874 309799003680 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 309799003681 dimer interface [polypeptide binding]; other site 309799003682 motif 1; other site 309799003683 motif 3; other site 309799003684 motif 2; other site 309799003685 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 309799003686 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 309799003687 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 309799003688 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 309799003689 dimer interface [polypeptide binding]; other site 309799003690 motif 1; other site 309799003691 active site 309799003692 motif 2; other site 309799003693 motif 3; other site 309799003694 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 309799003695 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 309799003696 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 309799003697 23S rRNA binding site [nucleotide binding]; other site 309799003698 L21 binding site [polypeptide binding]; other site 309799003699 L13 binding site [polypeptide binding]; other site 309799003700 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 309799003701 translation initiation factor IF-3; Region: infC; TIGR00168 309799003702 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 309799003703 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 309799003704 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 309799003705 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 309799003706 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 309799003707 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 309799003708 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 309799003709 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 309799003710 DNA binding residues [nucleotide binding] 309799003711 DNA primase; Validated; Region: dnaG; PRK05667 309799003712 CHC2 zinc finger; Region: zf-CHC2; pfam01807 309799003713 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 309799003714 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 309799003715 active site 309799003716 metal binding site [ion binding]; metal-binding site 309799003717 interdomain interaction site; other site 309799003718 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 309799003719 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 309799003720 Zn2+ binding site [ion binding]; other site 309799003721 Mg2+ binding site [ion binding]; other site 309799003722 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 309799003723 pyruvate phosphate dikinase; Provisional; Region: PRK09279 309799003724 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 309799003725 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 309799003726 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 309799003727 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 309799003728 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 309799003729 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 309799003730 dimer interface [polypeptide binding]; other site 309799003731 motif 1; other site 309799003732 active site 309799003733 motif 2; other site 309799003734 motif 3; other site 309799003735 Recombination protein O N terminal; Region: RecO_N; pfam11967 309799003736 DNA repair protein RecO; Region: reco; TIGR00613 309799003737 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 309799003738 intersubunit interface [polypeptide binding]; other site 309799003739 active site 309799003740 catalytic residue [active] 309799003741 GTPase Era; Reviewed; Region: era; PRK00089 309799003742 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 309799003743 G1 box; other site 309799003744 GTP/Mg2+ binding site [chemical binding]; other site 309799003745 Switch I region; other site 309799003746 G2 box; other site 309799003747 Switch II region; other site 309799003748 G3 box; other site 309799003749 G4 box; other site 309799003750 G5 box; other site 309799003751 KH domain; Region: KH_2; pfam07650 309799003752 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 309799003753 active site 309799003754 catalytic motif [active] 309799003755 Zn binding site [ion binding]; other site 309799003756 CTP synthetase; Validated; Region: pyrG; PRK05380 309799003757 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 309799003758 Catalytic site [active] 309799003759 active site 309799003760 UTP binding site [chemical binding]; other site 309799003761 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 309799003762 active site 309799003763 putative oxyanion hole; other site 309799003764 catalytic triad [active] 309799003765 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 309799003766 Domain of unknown function DUF21; Region: DUF21; pfam01595 309799003767 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 309799003768 Transporter associated domain; Region: CorC_HlyC; smart01091 309799003769 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219 309799003770 metal-binding heat shock protein; Provisional; Region: PRK00016 309799003771 PhoH-like protein; Region: PhoH; pfam02562 309799003772 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 309799003773 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 309799003774 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 309799003775 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 309799003776 FeS/SAM binding site; other site 309799003777 RNA methyltransferase, RsmE family; Region: TIGR00046 309799003778 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 309799003779 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 309799003780 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 309799003781 active site 309799003782 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 309799003783 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 309799003784 homotrimer interaction site [polypeptide binding]; other site 309799003785 putative active site [active] 309799003786 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 309799003787 active site 309799003788 dimerization interface [polypeptide binding]; other site 309799003789 ribonuclease PH; Reviewed; Region: rph; PRK00173 309799003790 Ribonuclease PH; Region: RNase_PH_bact; cd11362 309799003791 hexamer interface [polypeptide binding]; other site 309799003792 active site 309799003793 Fumarase C-terminus; Region: Fumerase_C; pfam05683 309799003794 fumarate hydratase; Provisional; Region: PRK06246 309799003795 Domain of unknown function (DUF4387); Region: DUF4387; pfam14330 309799003796 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 309799003797 methylaspartate ammonia-lyase; Region: B_methylAsp_ase; TIGR01502 309799003798 Methylaspartate ammonia lyase (3-methylaspartase, MAL) is a homodimeric enzyme, catalyzing the magnesium-dependent reversible alpha,beta-elimination of ammonia from L-threo-(2S,3S)-3-methylaspartic acid to mesaconic acid. This reaction is part of the...; Region: MAL; cd03314 309799003799 dimer interface [polypeptide binding]; other site 309799003800 active site 309799003801 Coenzyme B12-dependent glutamate mutase epsilon subunit-like family; contains proteins similar to Clostridium cochlearium glutamate mutase (Glm) and Streptomyces tendae Tu901 NikV. Glm catalyzes a carbon-skeleton rearrangement of L-glutamate to...; Region: Glm_e; cd00245 309799003802 substrate binding site [chemical binding]; other site 309799003803 B12 cofactor binding site [chemical binding]; other site 309799003804 heterodimer (sigma-epsilon) interface [polypeptide binding]; other site 309799003805 homodimer (epsilon-epsilon) interface [polypeptide binding]; other site 309799003806 MutL protein; Region: MutL; pfam13941 309799003807 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 309799003808 B12 binding domain of glutamate mutase (Glm). Glutamate mutase catalysis the conversion of (S)-glutamate with (2S,3S)-3-methylaspartate. The rearrangement reaction is initiated by the extraction of a hydrogen from the protein-bound substrate by a 5'...; Region: Glm_B12_BD; cd02072 309799003809 B12 binding site [chemical binding]; other site 309799003810 heterodimer interface [polypeptide binding]; other site 309799003811 cobalt ligand [ion binding]; other site 309799003812 M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683 309799003813 peptidase T-like protein; Region: PepT-like; TIGR01883 309799003814 metal binding site [ion binding]; metal-binding site 309799003815 putative dimer interface [polypeptide binding]; other site 309799003816 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 309799003817 AMIN domain; Region: AMIN; pfam11741 309799003818 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 309799003819 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 309799003820 active site 309799003821 metal binding site [ion binding]; metal-binding site 309799003822 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 309799003823 SmpB-tmRNA interface; other site 309799003824 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 309799003825 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 309799003826 NAD binding site [chemical binding]; other site 309799003827 homodimer interface [polypeptide binding]; other site 309799003828 active site 309799003829 substrate binding site [chemical binding]; other site 309799003830 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 309799003831 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 309799003832 inhibitor-cofactor binding pocket; inhibition site 309799003833 pyridoxal 5'-phosphate binding site [chemical binding]; other site 309799003834 catalytic residue [active] 309799003835 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 309799003836 Chain length determinant protein; Region: Wzz; pfam02706 309799003837 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 309799003838 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 309799003839 nucleotide binding site [chemical binding]; other site 309799003840 N-acetyl-L-glutamate binding site [chemical binding]; other site 309799003841 GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100 309799003842 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 309799003843 G1 box; other site 309799003844 GTP/Mg2+ binding site [chemical binding]; other site 309799003845 G2 box; other site 309799003846 Switch I region; other site 309799003847 G3 box; other site 309799003848 Switch II region; other site 309799003849 G4 box; other site 309799003850 G5 box; other site 309799003851 Roadblock/LC7 domain; Region: Robl_LC7; smart00960 309799003852 replicative DNA helicase; Region: DnaB; TIGR00665 309799003853 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 309799003854 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 309799003855 Walker A motif; other site 309799003856 ATP binding site [chemical binding]; other site 309799003857 Walker B motif; other site 309799003858 DNA binding loops [nucleotide binding] 309799003859 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 309799003860 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 309799003861 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 309799003862 Predicted membrane protein (DUF2232); Region: DUF2232; cl01728 309799003863 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 309799003864 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 309799003865 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 309799003866 dimer interface [polypeptide binding]; other site 309799003867 ssDNA binding site [nucleotide binding]; other site 309799003868 tetramer (dimer of dimers) interface [polypeptide binding]; other site 309799003869 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 309799003870 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 309799003871 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 309799003872 homodimer interface [polypeptide binding]; other site 309799003873 substrate-cofactor binding pocket; other site 309799003874 pyridoxal 5'-phosphate binding site [chemical binding]; other site 309799003875 catalytic residue [active] 309799003876 diaminopimelate decarboxylase; Region: lysA; TIGR01048 309799003877 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 309799003878 active site 309799003879 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 309799003880 substrate binding site [chemical binding]; other site 309799003881 catalytic residues [active] 309799003882 dimer interface [polypeptide binding]; other site 309799003883 homoserine dehydrogenase; Provisional; Region: PRK06349 309799003884 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 309799003885 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 309799003886 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 309799003887 threonine synthase; Reviewed; Region: PRK06721 309799003888 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 309799003889 homodimer interface [polypeptide binding]; other site 309799003890 pyridoxal 5'-phosphate binding site [chemical binding]; other site 309799003891 catalytic residue [active] 309799003892 homoserine kinase; Provisional; Region: PRK01212 309799003893 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 309799003894 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 309799003895 aspartate kinase; Reviewed; Region: PRK06635 309799003896 AAK_AK-DapG-like: Amino Acid Kinase Superfamily (AAK), AK-DapG-like; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the diaminopimelate-sensitive aspartokinase isoenzyme AKI (DapG), a monofunctional enzymes found in Bacilli; Region: AAK_AK-DapG-like; cd04246 309799003897 putative catalytic residues [active] 309799003898 putative nucleotide binding site [chemical binding]; other site 309799003899 putative aspartate binding site [chemical binding]; other site 309799003900 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 309799003901 putative allosteric regulatory site; other site 309799003902 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 309799003903 putative allosteric regulatory residue; other site 309799003904 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 309799003905 L11 interface [polypeptide binding]; other site 309799003906 putative EF-Tu interaction site [polypeptide binding]; other site 309799003907 putative EF-G interaction site [polypeptide binding]; other site 309799003908 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 309799003909 23S rRNA interface [nucleotide binding]; other site 309799003910 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 309799003911 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 309799003912 mRNA/rRNA interface [nucleotide binding]; other site 309799003913 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 309799003914 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 309799003915 23S rRNA interface [nucleotide binding]; other site 309799003916 L7/L12 interface [polypeptide binding]; other site 309799003917 putative thiostrepton binding site; other site 309799003918 L25 interface [polypeptide binding]; other site 309799003919 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 309799003920 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 309799003921 putative homodimer interface [polypeptide binding]; other site 309799003922 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 309799003923 heterodimer interface [polypeptide binding]; other site 309799003924 homodimer interface [polypeptide binding]; other site 309799003925 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 309799003926 elongation factor Tu; Reviewed; Region: PRK00049 309799003927 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 309799003928 G1 box; other site 309799003929 GEF interaction site [polypeptide binding]; other site 309799003930 GTP/Mg2+ binding site [chemical binding]; other site 309799003931 Switch I region; other site 309799003932 G2 box; other site 309799003933 G3 box; other site 309799003934 Switch II region; other site 309799003935 G4 box; other site 309799003936 G5 box; other site 309799003937 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 309799003938 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 309799003939 Antibiotic Binding Site [chemical binding]; other site 309799003940 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 309799003941 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 309799003942 RNA binding site [nucleotide binding]; other site 309799003943 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 309799003944 RNA binding site [nucleotide binding]; other site 309799003945 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 309799003946 RNA binding site [nucleotide binding]; other site 309799003947 S1 RNA binding domain; Region: S1; pfam00575 309799003948 RNA binding site [nucleotide binding]; other site 309799003949 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 309799003950 RNA binding site [nucleotide binding]; other site 309799003951 seryl-tRNA synthetase; Provisional; Region: PRK05431 309799003952 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 309799003953 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 309799003954 dimer interface [polypeptide binding]; other site 309799003955 active site 309799003956 motif 1; other site 309799003957 motif 2; other site 309799003958 motif 3; other site 309799003959 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08665 309799003960 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 309799003961 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 309799003962 active site 309799003963 dimer interface [polypeptide binding]; other site 309799003964 effector binding site; other site 309799003965 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 309799003966 TSCPD domain; Region: TSCPD; pfam12637 309799003967 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 309799003968 O-Antigen ligase; Region: Wzy_C; cl04850 309799003969 O-Antigen ligase; Region: Wzy_C; pfam04932 309799003970 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 309799003971 binding surface 309799003972 TPR motif; other site 309799003973 Tetratricopeptide repeat; Region: TPR_16; pfam13432 309799003974 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 309799003975 binding surface 309799003976 TPR repeat; Region: TPR_11; pfam13414 309799003977 TPR motif; other site 309799003978 phosphofructokinase; Region: PFK_mixed; TIGR02483 309799003979 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 309799003980 active site 309799003981 ADP/pyrophosphate binding site [chemical binding]; other site 309799003982 dimerization interface [polypeptide binding]; other site 309799003983 allosteric effector site; other site 309799003984 fructose-1,6-bisphosphate binding site; other site 309799003985 Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; pfam09835 309799003986 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 309799003987 nucleotide binding site/active site [active] 309799003988 HIT family signature motif; other site 309799003989 catalytic residue [active] 309799003990 6-phosphofructokinase; Provisional; Region: PRK03202 309799003991 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 309799003992 active site 309799003993 ADP/pyrophosphate binding site [chemical binding]; other site 309799003994 dimerization interface [polypeptide binding]; other site 309799003995 allosteric effector site; other site 309799003996 fructose-1,6-bisphosphate binding site; other site 309799003997 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 309799003998 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 309799003999 Probable metal-binding protein (DUF2387); Region: DUF2387; cl01410 309799004000 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 309799004001 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06826 309799004002 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 309799004003 active site 309799004004 PHP Thumb interface [polypeptide binding]; other site 309799004005 metal binding site [ion binding]; metal-binding site 309799004006 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 309799004007 generic binding surface II; other site 309799004008 generic binding surface I; other site 309799004009 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 309799004010 Fe-S cluster binding site [ion binding]; other site 309799004011 active site 309799004012 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 309799004013 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 309799004014 S-adenosylmethionine binding site [chemical binding]; other site 309799004015 spermidine synthase; Provisional; Region: PRK00811 309799004016 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 309799004017 S-adenosylmethionine binding site [chemical binding]; other site 309799004018 Acylphosphatase; Region: Acylphosphatase; pfam00708 309799004019 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 309799004020 Part of AAA domain; Region: AAA_19; pfam13245 309799004021 Family description; Region: UvrD_C_2; pfam13538 309799004022 Septum formation topological specificity factor MinE; Region: MinE; pfam03776 309799004023 septum site-determining protein MinD; Region: minD_bact; TIGR01968 309799004024 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 309799004025 P-loop; other site 309799004026 ADP binding residues [chemical binding]; other site 309799004027 Switch I; other site 309799004028 Switch II; other site 309799004029 septum formation inhibitor; Reviewed; Region: minC; PRK00513 309799004030 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 309799004031 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 309799004032 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 309799004033 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 309799004034 rod shape-determining protein MreC; Provisional; Region: PRK13922 309799004035 rod shape-determining protein MreC; Region: MreC; pfam04085 309799004036 rod shape-determining protein MreB; Provisional; Region: PRK13927 309799004037 MreB and similar proteins; Region: MreB_like; cd10225 309799004038 nucleotide binding site [chemical binding]; other site 309799004039 Mg binding site [ion binding]; other site 309799004040 putative protofilament interaction site [polypeptide binding]; other site 309799004041 RodZ interaction site [polypeptide binding]; other site 309799004042 Maf-like protein; Region: Maf; pfam02545 309799004043 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 309799004044 active site 309799004045 dimer interface [polypeptide binding]; other site 309799004046 Uncharacterized conserved protein [Function unknown]; Region: COG1284 309799004047 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 309799004048 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 309799004049 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 309799004050 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 309799004051 polysaccharide pyruvyl transferase CsaB; Region: S_layer_CsaB; TIGR03609 309799004052 peptide chain release factor 2; Provisional; Region: PRK05589 309799004053 This domain is found in peptide chain release factors; Region: PCRF; smart00937 309799004054 RF-1 domain; Region: RF-1; pfam00472 309799004055 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 309799004056 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 309799004057 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 309799004058 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 309799004059 nucleotide binding region [chemical binding]; other site 309799004060 ATP-binding site [chemical binding]; other site 309799004061 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 309799004062 30S subunit binding site; other site 309799004063 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 309799004064 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 309799004065 active site 309799004066 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 309799004067 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 309799004068 active site 309799004069 homodimer interface [polypeptide binding]; other site 309799004070 Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593 309799004071 putative active site [active] 309799004072 Mn binding site [ion binding]; other site 309799004073 S-adenosylmethionine decarboxylase; Region: AdoMet_dc; pfam02675 309799004074 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 309799004075 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 309799004076 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 309799004077 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 309799004078 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 309799004079 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 309799004080 active site 309799004081 substrate binding site [chemical binding]; other site 309799004082 cosubstrate binding site; other site 309799004083 catalytic site [active] 309799004084 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 309799004085 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 309799004086 dimerization interface [polypeptide binding]; other site 309799004087 putative ATP binding site [chemical binding]; other site 309799004088 Glutamine phosphoribosylpyrophosphate amidotransferase [Nucleotide transport and metabolism]; Region: PurF; COG0034 309799004089 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 309799004090 active site 309799004091 tetramer interface [polypeptide binding]; other site 309799004092 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 309799004093 active site 309799004094 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 309799004095 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 309799004096 dimerization interface [polypeptide binding]; other site 309799004097 ATP binding site [chemical binding]; other site 309799004098 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 309799004099 dimerization interface [polypeptide binding]; other site 309799004100 ATP binding site [chemical binding]; other site 309799004101 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 309799004102 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 309799004103 putative active site [active] 309799004104 catalytic triad [active] 309799004105 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700 309799004106 adenylosuccinate lyase; Provisional; Region: PRK07492 309799004107 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 309799004108 tetramer interface [polypeptide binding]; other site 309799004109 active site 309799004110 Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998 309799004111 enolase; Provisional; Region: eno; PRK00077 309799004112 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 309799004113 dimer interface [polypeptide binding]; other site 309799004114 metal binding site [ion binding]; metal-binding site 309799004115 substrate binding pocket [chemical binding]; other site 309799004116 Predicted phosphoribosyltransferases [General function prediction only]; Region: COG2236 309799004117 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 309799004118 active site 309799004119 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 309799004120 active site 309799004121 Ap6A binding site [chemical binding]; other site 309799004122 nudix motif; other site 309799004123 metal binding site [ion binding]; metal-binding site 309799004124 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 309799004125 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 309799004126 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 309799004127 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 309799004128 active site 309799004129 Substrate binding site; other site 309799004130 Mg++ binding site; other site 309799004131 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 309799004132 putative trimer interface [polypeptide binding]; other site 309799004133 putative CoA binding site [chemical binding]; other site 309799004134 phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990 309799004135 GTP-mannose-1-phosphate guanyltransferase (MPG1 transferase), also known as GDP-mannose pyrophosphorylase, is a bifunctional enzyme with both phosphomannose isomerase (PMI) activity and GDP-mannose phosphorylase (GMP) activity. The protein contains an...; Region: MPG1_transferase; cd05805 309799004136 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 309799004137 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 309799004138 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 309799004139 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 309799004140 HIGH motif; other site 309799004141 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 309799004142 active site 309799004143 KMSKS motif; other site 309799004144 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 309799004145 tRNA binding surface [nucleotide binding]; other site 309799004146 anticodon binding site; other site 309799004147 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 309799004148 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 309799004149 cobalamin binding residues [chemical binding]; other site 309799004150 putative BtuC binding residues; other site 309799004151 dimer interface [polypeptide binding]; other site 309799004152 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 309799004153 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 309799004154 ABC-ATPase subunit interface; other site 309799004155 dimer interface [polypeptide binding]; other site 309799004156 putative PBP binding regions; other site 309799004157 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 309799004158 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 309799004159 Walker A/P-loop; other site 309799004160 ATP binding site [chemical binding]; other site 309799004161 Q-loop/lid; other site 309799004162 ABC transporter signature motif; other site 309799004163 Walker B; other site 309799004164 D-loop; other site 309799004165 H-loop/switch region; other site 309799004166 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 309799004167 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 309799004168 substrate binding site [chemical binding]; other site 309799004169 hexamer interface [polypeptide binding]; other site 309799004170 metal binding site [ion binding]; metal-binding site 309799004171 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 309799004172 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 309799004173 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 309799004174 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 309799004175 FeS/SAM binding site; other site 309799004176 16S rRNA methyltransferase B; Provisional; Region: PRK14902 309799004177 NusB family; Region: NusB; pfam01029 309799004178 putative RNA binding site [nucleotide binding]; other site 309799004179 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 309799004180 S-adenosylmethionine binding site [chemical binding]; other site 309799004181 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298 309799004182 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 309799004183 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 309799004184 putative active site [active] 309799004185 substrate binding site [chemical binding]; other site 309799004186 putative cosubstrate binding site; other site 309799004187 catalytic site [active] 309799004188 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 309799004189 substrate binding site [chemical binding]; other site 309799004190 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 309799004191 active site 309799004192 catalytic residues [active] 309799004193 metal binding site [ion binding]; metal-binding site 309799004194 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 309799004195 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 309799004196 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 309799004197 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 309799004198 catalytic site [active] 309799004199 G-X2-G-X-G-K; other site 309799004200 hypothetical protein; Provisional; Region: PRK04323 309799004201 hypothetical protein; Provisional; Region: PRK11820 309799004202 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 309799004203 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 309799004204 Predicted methyltransferases [General function prediction only]; Region: COG0313 309799004205 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 309799004206 putative SAM binding site [chemical binding]; other site 309799004207 putative homodimer interface [polypeptide binding]; other site 309799004208 putative phosphate acyltransferase; Provisional; Region: PRK05331 309799004209 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 309799004210 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 309799004211 Walker A motif; other site 309799004212 ATP binding site [chemical binding]; other site 309799004213 Walker B motif; other site 309799004214 This family is most closely related to the GT1 family of glycosyltransferases. ORF704 in E. coli has been shown to be involved in the biosynthesis of O-specific mannose homopolysaccharides; Region: GT1_ecORF704_like; cd03822 309799004215 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 309799004216 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 309799004217 Dehydroquinase class II; Region: DHquinase_II; pfam01220 309799004218 trimer interface [polypeptide binding]; other site 309799004219 active site 309799004220 dimer interface [polypeptide binding]; other site 309799004221 shikimate kinase; Reviewed; Region: aroK; PRK00131 309799004222 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 309799004223 ADP binding site [chemical binding]; other site 309799004224 magnesium binding site [ion binding]; other site 309799004225 putative shikimate binding site; other site 309799004226 spermidine synthase; Provisional; Region: PRK00811 309799004227 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 309799004228 S-adenosylmethionine binding site [chemical binding]; other site 309799004229 S-adenosylmethionine decarboxylase; Region: AdoMet_dc; cl00687 309799004230 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 309799004231 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 309799004232 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 309799004233 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 309799004234 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 309799004235 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 309799004236 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 309799004237 FeS/SAM binding site; other site 309799004238 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 309799004239 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 309799004240 non-specific DNA binding site [nucleotide binding]; other site 309799004241 salt bridge; other site 309799004242 sequence-specific DNA binding site [nucleotide binding]; other site 309799004243 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 309799004244 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 309799004245 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 309799004246 RNA binding surface [nucleotide binding]; other site 309799004247 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 309799004248 active site 309799004249 Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612 309799004250 ScpA/B protein; Region: ScpA_ScpB; cl00598 309799004251 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 309799004252 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 309799004253 active site 309799004254 HIGH motif; other site 309799004255 dimer interface [polypeptide binding]; other site 309799004256 KMSKS motif; other site 309799004257 Peptidase family M50; Region: Peptidase_M50; pfam02163 309799004258 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 309799004259 active site 309799004260 putative substrate binding region [chemical binding]; other site 309799004261 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 309799004262 pyrimidine-nucleoside phosphorylase; Region: Y_phosphoryl; TIGR02644 309799004263 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 309799004264 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 309799004265 phosphopentomutase; Provisional; Region: PRK05362 309799004266 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 309799004267 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 309799004268 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 309799004269 active site 309799004270 DNA binding site [nucleotide binding] 309799004271 Int/Topo IB signature motif; other site 309799004272 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 309799004273 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 309799004274 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 309799004275 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 309799004276 homotrimer interaction site [polypeptide binding]; other site 309799004277 zinc binding site [ion binding]; other site 309799004278 CDP-binding sites; other site 309799004279 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 309799004280 substrate binding site; other site 309799004281 dimer interface; other site 309799004282 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 309799004283 putative active site [active] 309799004284 TRAM domain; Region: TRAM; cl01282 309799004285 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 309799004286 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 309799004287 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 309799004288 DNA repair protein RadA; Provisional; Region: PRK11823 309799004289 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 309799004290 Walker A motif; other site 309799004291 ATP binding site [chemical binding]; other site 309799004292 Walker B motif; other site 309799004293 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 309799004294 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 309799004295 Clp amino terminal domain; Region: Clp_N; pfam02861 309799004296 Clp amino terminal domain; Region: Clp_N; pfam02861 309799004297 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 309799004298 Walker A motif; other site 309799004299 ATP binding site [chemical binding]; other site 309799004300 Walker B motif; other site 309799004301 arginine finger; other site 309799004302 UvrB/uvrC motif; Region: UVR; pfam02151 309799004303 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 309799004304 Walker A motif; other site 309799004305 ATP binding site [chemical binding]; other site 309799004306 Walker B motif; other site 309799004307 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 309799004308 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 309799004309 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 309799004310 ADP binding site [chemical binding]; other site 309799004311 phosphagen binding site; other site 309799004312 substrate specificity loop; other site 309799004313 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 309799004314 UvrB/uvrC motif; Region: UVR; pfam02151 309799004315 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 309799004316 predicted active site [active] 309799004317 catalytic triad [active] 309799004318 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 309799004319 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 309799004320 active site 309799004321 multimer interface [polypeptide binding]; other site 309799004322 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 309799004323 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 309799004324 GIY-YIG motif/motif A; other site 309799004325 active site 309799004326 catalytic site [active] 309799004327 putative DNA binding site [nucleotide binding]; other site 309799004328 metal binding site [ion binding]; metal-binding site 309799004329 UvrB/uvrC motif; Region: UVR; pfam02151 309799004330 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 309799004331 Helix-hairpin-helix motif; Region: HHH; pfam00633 309799004332 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 309799004333 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 309799004334 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 309799004335 active site 309799004336 HIGH motif; other site 309799004337 KMSK motif region; other site 309799004338 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 309799004339 tRNA binding surface [nucleotide binding]; other site 309799004340 anticodon binding site; other site 309799004341 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 309799004342 Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483 309799004343 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 309799004344 Zn2+ binding site [ion binding]; other site 309799004345 Mg2+ binding site [ion binding]; other site 309799004346 QueT transporter; Region: QueT; pfam06177 309799004347 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 309799004348 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 309799004349 active site 309799004350 HIGH motif; other site 309799004351 dimer interface [polypeptide binding]; other site 309799004352 KMSKS motif; other site 309799004353 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 309799004354 RNA binding surface [nucleotide binding]; other site 309799004355 Domain of unknown function (DUF348); Region: DUF348; pfam03990 309799004356 G5 domain; Region: G5; pfam07501 309799004357 3D domain; Region: 3D; cl01439 309799004358 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 309799004359 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 309799004360 S-adenosylmethionine binding site [chemical binding]; other site 309799004361 4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate synthase [Lipid metabolism]; Region: IspE; COG1947 309799004362 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 309799004363 threonine dehydratase; Provisional; Region: PRK08198 309799004364 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 309799004365 tetramer interface [polypeptide binding]; other site 309799004366 pyridoxal 5'-phosphate binding site [chemical binding]; other site 309799004367 catalytic residue [active] 309799004368 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 309799004369 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 309799004370 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 309799004371 oligomer interface [polypeptide binding]; other site 309799004372 active site 309799004373 metal binding site [ion binding]; metal-binding site 309799004374 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 309799004375 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 309799004376 Ligand Binding Site [chemical binding]; other site 309799004377 Domain of unknown function (DUF814); Region: DUF814; pfam05670 309799004378 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 309799004379 DHH family; Region: DHH; pfam01368 309799004380 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 309799004381 FOG: CBS domain [General function prediction only]; Region: COG0517 309799004382 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with an upstream DHH domain which performs a phosphoesterase function and a downstream polyA polymerase domain. CBS is a small domain originally...; Region: CBS_pair_DHH_polyA_Pol_assoc; cd04595 309799004383 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 309799004384 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 309799004385 active site 309799004386 NTP binding site [chemical binding]; other site 309799004387 metal binding triad [ion binding]; metal-binding site 309799004388 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 309799004389 alanine racemase; Reviewed; Region: alr; PRK00053 309799004390 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 309799004391 active site 309799004392 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 309799004393 dimer interface [polypeptide binding]; other site 309799004394 substrate binding site [chemical binding]; other site 309799004395 catalytic residues [active] 309799004396 ATP synthase subunit D; Region: ATP-synt_D; cl00613 309799004397 V-type ATP synthase subunit B; Provisional; Region: PRK04196 309799004398 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 309799004399 V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_B; cd01135 309799004400 Walker A motif homologous position; other site 309799004401 Walker B motif; other site 309799004402 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 309799004403 V-type ATP synthase subunit A; Provisional; Region: PRK04192 309799004404 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 309799004405 V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_A; cd01134 309799004406 Walker A motif/ATP binding site; other site 309799004407 Walker B motif; other site 309799004408 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 309799004409 ATP synthase (F/14-kDa) subunit; Region: ATP-synt_F; cl00632 309799004410 V-type ATP synthase subunit K; Validated; Region: PRK06558 309799004411 V-type ATP synthase subunit I; Validated; Region: PRK05771 309799004412 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 309799004413 Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility; Region: MEMO_like; cd07361 309799004414 putative ligand binding pocket/active site [active] 309799004415 putative metal binding site [ion binding]; other site 309799004416 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 309799004417 putative active site [active] 309799004418 catalytic residue [active] 309799004419 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 309799004420 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 309799004421 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 309799004422 ATP binding site [chemical binding]; other site 309799004423 putative Mg++ binding site [ion binding]; other site 309799004424 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 309799004425 nucleotide binding region [chemical binding]; other site 309799004426 ATP-binding site [chemical binding]; other site 309799004427 TRCF domain; Region: TRCF; pfam03461 309799004428 SurA N-terminal domain; Region: SurA_N_3; cl07813 309799004429 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 309799004430 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 309799004431 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 309799004432 homodimer interface [polypeptide binding]; other site 309799004433 metal binding site [ion binding]; metal-binding site 309799004434 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 309799004435 homodimer interface [polypeptide binding]; other site 309799004436 active site 309799004437 putative chemical substrate binding site [chemical binding]; other site 309799004438 metal binding site [ion binding]; metal-binding site 309799004439 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 309799004440 IHF - DNA interface [nucleotide binding]; other site 309799004441 IHF dimer interface [polypeptide binding]; other site 309799004442 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 309799004443 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 309799004444 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 309799004445 lipoyl attachment site [posttranslational modification]; other site 309799004446 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 309799004447 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 309799004448 tetramer interface [polypeptide binding]; other site 309799004449 pyridoxal 5'-phosphate binding site [chemical binding]; other site 309799004450 catalytic residue [active] 309799004451 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 309799004452 tetramer interface [polypeptide binding]; other site 309799004453 pyridoxal 5'-phosphate binding site [chemical binding]; other site 309799004454 catalytic residue [active] 309799004455 Uncharacterized homolog of biotin synthetase [Function unknown]; Region: COG1856 309799004456 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 309799004457 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 309799004458 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 309799004459 active site 309799004460 NTP binding site [chemical binding]; other site 309799004461 metal binding triad [ion binding]; metal-binding site 309799004462 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 309799004463 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 309799004464 Zn2+ binding site [ion binding]; other site 309799004465 Mg2+ binding site [ion binding]; other site 309799004466 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 309799004467 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 309799004468 active site 309799004469 Int/Topo IB signature motif; other site 309799004470 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 309799004471 Glucose inhibited division protein A; Region: GIDA; pfam01134 309799004472 DNA topoisomerase I; Validated; Region: PRK05582 309799004473 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 309799004474 active site 309799004475 interdomain interaction site; other site 309799004476 putative metal-binding site [ion binding]; other site 309799004477 nucleotide binding site [chemical binding]; other site 309799004478 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 309799004479 domain I; other site 309799004480 DNA binding groove [nucleotide binding] 309799004481 phosphate binding site [ion binding]; other site 309799004482 domain II; other site 309799004483 domain III; other site 309799004484 nucleotide binding site [chemical binding]; other site 309799004485 catalytic site [active] 309799004486 domain IV; other site 309799004487 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 309799004488 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 309799004489 DNA protecting protein DprA; Region: dprA; TIGR00732 309799004490 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 309799004491 MarR family; Region: MarR_2; pfam12802 309799004492 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 309799004493 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 309799004494 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 309799004495 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 309799004496 Walker A motif; other site 309799004497 ATP binding site [chemical binding]; other site 309799004498 Walker B motif; other site 309799004499 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 309799004500 hypothetical protein; Reviewed; Region: PRK12497 309799004501 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 309799004502 RNA/DNA hybrid binding site [nucleotide binding]; other site 309799004503 active site 309799004504 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 309799004505 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 309799004506 Catalytic site [active] 309799004507 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 309799004508 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 309799004509 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 309799004510 RimM N-terminal domain; Region: RimM; pfam01782 309799004511 PRC-barrel domain; Region: PRC; pfam05239 309799004512 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 309799004513 KH domain; Region: KH_4; pfam13083 309799004514 G-X-X-G motif; other site 309799004515 ribosomal protein S16; Region: S16; TIGR00002 309799004516 signal recognition particle protein; Provisional; Region: PRK10867 309799004517 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 309799004518 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 309799004519 P loop; other site 309799004520 GTP binding site [chemical binding]; other site 309799004521 Signal peptide binding domain; Region: SRP_SPB; pfam02978 309799004522 beta-D-glucuronidase; Provisional; Region: PRK10150 309799004523 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 309799004524 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 309799004525 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 309799004526 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 309799004527 dimerization interface [polypeptide binding]; other site 309799004528 putative DNA binding site [nucleotide binding]; other site 309799004529 putative Zn2+ binding site [ion binding]; other site 309799004530 Protein of unknown function (DUF554); Region: DUF554; pfam04474 309799004531 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 309799004532 GMP synthase; Reviewed; Region: guaA; PRK00074 309799004533 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 309799004534 AMP/PPi binding site [chemical binding]; other site 309799004535 candidate oxyanion hole; other site 309799004536 catalytic triad [active] 309799004537 potential glutamine specificity residues [chemical binding]; other site 309799004538 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 309799004539 ATP Binding subdomain [chemical binding]; other site 309799004540 Ligand Binding sites [chemical binding]; other site 309799004541 Dimerization subdomain; other site 309799004542 Protein of unknown function DUF111; Region: DUF111; pfam01969 309799004543 NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691 309799004544 AIR carboxylase; Region: AIRC; smart01001 309799004545 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 309799004546 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 309799004547 Mg2+ binding site [ion binding]; other site 309799004548 G-X-G motif; other site 309799004549 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 309799004550 anchoring element; other site 309799004551 dimer interface [polypeptide binding]; other site 309799004552 ATP binding site [chemical binding]; other site 309799004553 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 309799004554 active site 309799004555 putative metal-binding site [ion binding]; other site 309799004556 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 309799004557 Protein of unknown function (DUF721); Region: DUF721; pfam05258 309799004558 recombination protein F; Reviewed; Region: recF; PRK00064 309799004559 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 309799004560 Walker A/P-loop; other site 309799004561 ATP binding site [chemical binding]; other site 309799004562 Q-loop/lid; other site 309799004563 S4 domain; Region: S4_2; cl17325 309799004564 DNA polymerase III subunit beta; Validated; Region: PRK05643 309799004565 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 309799004566 putative DNA binding surface [nucleotide binding]; other site 309799004567 dimer interface [polypeptide binding]; other site 309799004568 beta-clamp/clamp loader binding surface; other site 309799004569 beta-clamp/translesion DNA polymerase binding surface; other site 309799004570 Predicted transcriptional regulator [Transcription]; Region: COG1959 309799004571 Transcriptional regulator; Region: Rrf2; pfam02082 309799004572 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 309799004573 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 309799004574 Walker A/P-loop; other site 309799004575 ATP binding site [chemical binding]; other site 309799004576 Q-loop/lid; other site 309799004577 ABC transporter signature motif; other site 309799004578 Walker B; other site 309799004579 D-loop; other site 309799004580 H-loop/switch region; other site 309799004581 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 309799004582 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 309799004583 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 309799004584 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; cl17726 309799004585 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 309799004586 Coenzyme A binding pocket [chemical binding]; other site 309799004587 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 309799004588 dimerization interface [polypeptide binding]; other site 309799004589 putative DNA binding site [nucleotide binding]; other site 309799004590 putative Zn2+ binding site [ion binding]; other site 309799004591 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 309799004592 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 309799004593 putative dimer interface [polypeptide binding]; other site 309799004594 Found in ATP-dependent protease La (LON); Region: LON; smart00464 309799004595 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 309799004596 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 309799004597 Walker A motif; other site 309799004598 ATP binding site [chemical binding]; other site 309799004599 Walker B motif; other site 309799004600 arginine finger; other site 309799004601 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 309799004602 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 309799004603 peptide chain release factor 1; Provisional; Region: PRK04011 309799004604 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 309799004605 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 309799004606 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 309799004607 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 309799004608 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 309799004609 HIGH motif; other site 309799004610 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 309799004611 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 309799004612 active site 309799004613 KMSKS motif; other site 309799004614 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 309799004615 tRNA binding surface [nucleotide binding]; other site 309799004616 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 309799004617 Zn binding site [ion binding]; other site 309799004618 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 309799004619 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 309799004620 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 309799004621 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 309799004622 Walker A/P-loop; other site 309799004623 ATP binding site [chemical binding]; other site 309799004624 Q-loop/lid; other site 309799004625 ABC transporter signature motif; other site 309799004626 Walker B; other site 309799004627 D-loop; other site 309799004628 H-loop/switch region; other site 309799004629 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 309799004630 metal binding site 2 [ion binding]; metal-binding site 309799004631 putative DNA binding helix; other site 309799004632 metal binding site 1 [ion binding]; metal-binding site 309799004633 dimer interface [polypeptide binding]; other site 309799004634 structural Zn2+ binding site [ion binding]; other site 309799004635 FeoA domain; Region: FeoA; pfam04023 309799004636 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 309799004637 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 309799004638 G1 box; other site 309799004639 GTP/Mg2+ binding site [chemical binding]; other site 309799004640 Switch I region; other site 309799004641 G2 box; other site 309799004642 G3 box; other site 309799004643 Switch II region; other site 309799004644 G4 box; other site 309799004645 G5 box; other site 309799004646 Nucleoside recognition; Region: Gate; pfam07670 309799004647 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 309799004648 Nucleoside recognition; Region: Gate; pfam07670 309799004649 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 309799004650 active site 309799004651 dimer interface [polypeptide binding]; other site 309799004652 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 309799004653 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 309799004654 heterodimer interface [polypeptide binding]; other site 309799004655 active site 309799004656 FMN binding site [chemical binding]; other site 309799004657 homodimer interface [polypeptide binding]; other site 309799004658 substrate binding site [chemical binding]; other site 309799004659 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 309799004660 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 309799004661 FAD binding pocket [chemical binding]; other site 309799004662 FAD binding motif [chemical binding]; other site 309799004663 phosphate binding motif [ion binding]; other site 309799004664 beta-alpha-beta structure motif; other site 309799004665 NAD binding pocket [chemical binding]; other site 309799004666 Iron coordination center [ion binding]; other site 309799004667 dihydroorotase; Validated; Region: pyrC; PRK09357 309799004668 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 309799004669 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 309799004670 active site 309799004671 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 309799004672 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 309799004673 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 309799004674 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 309799004675 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 309799004676 active site 309799004677 PyrR binding site 309799004678 Methyltransferase domain; Region: Methyltransf_31; pfam13847 309799004679 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 309799004680 S-adenosylmethionine binding site [chemical binding]; other site 309799004681 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 309799004682 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 309799004683 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 309799004684 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 309799004685 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 309799004686 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 309799004687 metal-binding site [ion binding] 309799004688 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 309799004689 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 309799004690 metal-binding site [ion binding] 309799004691 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 309799004692 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 309799004693 motif II; other site 309799004694 NTPase; Region: NTPase_1; pfam03266 309799004695 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 309799004696 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 309799004697 uncharacterized subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_1; cd07774 309799004698 putative N- and C-terminal domain interface [polypeptide binding]; other site 309799004699 putative active site [active] 309799004700 putative MgATP binding site [chemical binding]; other site 309799004701 catalytic site [active] 309799004702 metal binding site [ion binding]; metal-binding site 309799004703 putative carbohydrate binding site [chemical binding]; other site 309799004704 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 309799004705 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 309799004706 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 309799004707 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 309799004708 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 309799004709 Carbohydrate binding domain X2; Region: CBM_X2; pfam03442 309799004710 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 309799004711 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 309799004712 dimer interface [polypeptide binding]; other site 309799004713 conserved gate region; other site 309799004714 putative PBP binding loops; other site 309799004715 ABC-ATPase subunit interface; other site 309799004716 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 309799004717 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 309799004718 ABC-ATPase subunit interface; other site 309799004719 Mlo family; Region: Mlo; pfam03094 309799004720 NHL repeat; Region: NHL; pfam01436 309799004721 NHL repeat; Region: NHL; pfam01436 309799004722 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 309799004723 TPR motif; other site 309799004724 Yip1 domain; Region: Yip1; pfam04893 309799004725 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 309799004726 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 309799004727 dimer interface [polypeptide binding]; other site 309799004728 conserved gate region; other site 309799004729 putative PBP binding loops; other site 309799004730 ABC-ATPase subunit interface; other site 309799004731 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 309799004732 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 309799004733 dimer interface [polypeptide binding]; other site 309799004734 conserved gate region; other site 309799004735 putative PBP binding loops; other site 309799004736 ABC-ATPase subunit interface; other site 309799004737 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 309799004738 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 309799004739 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 309799004740 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 309799004741 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 309799004742 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 309799004743 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 309799004744 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 309799004745 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 309799004746 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 309799004747 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 309799004748 catalytic core [active] 309799004749 Clp amino terminal domain; Region: Clp_N; pfam02861 309799004750 Clp amino terminal domain; Region: Clp_N; pfam02861 309799004751 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 309799004752 Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483 309799004753 hypothetical protein; Provisional; Region: PRK08609 309799004754 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 309799004755 active site 309799004756 primer binding site [nucleotide binding]; other site 309799004757 NTP binding site [chemical binding]; other site 309799004758 metal binding triad [ion binding]; metal-binding site 309799004759 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 309799004760 active site 309799004761 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 309799004762 DHH family; Region: DHH; pfam01368 309799004763 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 309799004764 Protein export membrane protein; Region: SecD_SecF; cl14618 309799004765 protein-export membrane protein SecD; Region: secD; TIGR01129 309799004766 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 309799004767 Preprotein translocase subunit; Region: YajC; pfam02699 309799004768 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 309799004769 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 309799004770 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 309799004771 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 309799004772 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 309799004773 Stage II sporulation protein; Region: SpoIID; pfam08486 309799004774 Protein of unknown function (DUF2905); Region: DUF2905; pfam11146 309799004775 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 309799004776 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl17465 309799004777 Diacylglycerol kinase accessory domain; Region: DAGK_acc; cl02440 309799004778 Uncharacterized BCR, COG1636; Region: DUF208; pfam02677 309799004779 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 309799004780 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 309799004781 Walker A motif; other site 309799004782 ATP binding site [chemical binding]; other site 309799004783 Walker B motif; other site 309799004784 arginine finger; other site 309799004785 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 309799004786 Holliday junction resolvasome, DNA-binding subunit [DNA replication, recombination, and repair]; Region: RuvA; COG0632 309799004787 RuvA N terminal domain; Region: RuvA_N; pfam01330 309799004788 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 309799004789 active site 309799004790 putative DNA-binding cleft [nucleotide binding]; other site 309799004791 dimer interface [polypeptide binding]; other site 309799004792 hypothetical protein; Validated; Region: PRK00110 309799004793 phosphoglycolate phosphatase; Provisional; Region: PRK01158 309799004794 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 309799004795 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 309799004796 YjeF-related protein N-terminus; Region: YjeF_N; cl00318 309799004797 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 309799004798 putative substrate binding site [chemical binding]; other site 309799004799 putative ATP binding site [chemical binding]; other site 309799004800 Protein of unknown function (DUF1312); Region: DUF1312; pfam07009 309799004801 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 309799004802 putative FMN binding site [chemical binding]; other site 309799004803 NADPH bind site [chemical binding]; other site 309799004804 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 309799004805 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 309799004806 dimer interface [polypeptide binding]; other site 309799004807 active site 309799004808 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 309799004809 dimer interface [polypeptide binding]; other site 309799004810 active site 309799004811 Divergent PAP2 family; Region: DUF212; pfam02681 309799004812 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 309799004813 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 309799004814 putative ADP-binding pocket [chemical binding]; other site 309799004815 NurA nuclease; Region: NurA; smart00933 309799004816 HerA helicase [Replication, recombination, and repair]; Region: COG0433 309799004817 Domain of unknown function DUF87; Region: DUF87; pfam01935 309799004818 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 309799004819 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 309799004820 active site 309799004821 metal binding site [ion binding]; metal-binding site 309799004822 DNA binding site [nucleotide binding] 309799004823 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 309799004824 AAA domain; Region: AAA_23; pfam13476 309799004825 Walker A/P-loop; other site 309799004826 ATP binding site [chemical binding]; other site 309799004827 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 309799004828 ABC transporter signature motif; other site 309799004829 Walker B; other site 309799004830 D-loop; other site 309799004831 H-loop/switch region; other site 309799004832 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 309799004833 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 309799004834 active site 309799004835 tetramer interface; other site 309799004836 Cupin domain; Region: Cupin_2; cl17218 309799004837 trans-homoaconitate synthase; Reviewed; Region: aksA; PRK11858 309799004838 Streptomyces rubellomurinus FrbC and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_NifV; cd07939 309799004839 active site 309799004840 catalytic residues [active] 309799004841 metal binding site [ion binding]; metal-binding site 309799004842 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 309799004843 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 309799004844 substrate binding site [chemical binding]; other site 309799004845 ligand binding site [chemical binding]; other site 309799004846 3-isopropylmalate dehydratase small subunit; Reviewed; Region: leuD; PRK00439 309799004847 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 309799004848 substrate binding site [chemical binding]; other site 309799004849 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 309799004850 iron-containing alcohol dehydrogenases (Fe-ADH)-like; Region: Fe-ADH; cd08551 309799004851 active site 309799004852 metal binding site [ion binding]; metal-binding site 309799004853 Putative glucose-1-phosphate thymidylyltransferase, C-terminal Left-handed parallel beta-Helix (LbH) domain: Proteins in this family show simlarity to glucose-1-phosphate adenylyltransferases in that they contain N-terminal catalytic domains that...; Region: LbH_G1P_TT_C_like; cd05636 309799004854 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 309799004855 FAD binding site [chemical binding]; other site 309799004856 Methylene-tetrahydrofolate reductase C terminal; Region: MTHFR_C; pfam12225 309799004857 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190 309799004858 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 309799004859 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 309799004860 homodimer interface [polypeptide binding]; other site 309799004861 NADP binding site [chemical binding]; other site 309799004862 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 309799004863 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 309799004864 Potassium binding sites [ion binding]; other site 309799004865 Cesium cation binding sites [ion binding]; other site 309799004866 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 309799004867 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 309799004868 active site 309799004869 metal binding site [ion binding]; metal-binding site 309799004870 homotetramer interface [polypeptide binding]; other site 309799004871 Nitroreductase-like family 2. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_2; cd02138 309799004872 putative FMN binding site [chemical binding]; other site 309799004873 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 309799004874 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 309799004875 Metal-binding active site; metal-binding site 309799004876 Chorismate mutase type II; Region: CM_2; pfam01817 309799004877 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 309799004878 Prephenate dehydratase; Region: PDT; pfam00800 309799004879 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 309799004880 putative L-Phe binding site [chemical binding]; other site 309799004881 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 309799004882 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 309799004883 TM-ABC transporter signature motif; other site 309799004884 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 309799004885 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 309799004886 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 309799004887 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 309799004888 Walker A/P-loop; other site 309799004889 ATP binding site [chemical binding]; other site 309799004890 Q-loop/lid; other site 309799004891 ABC transporter signature motif; other site 309799004892 Walker B; other site 309799004893 D-loop; other site 309799004894 H-loop/switch region; other site 309799004895 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 309799004896 C factor cell-cell signaling protein; Provisional; Region: PRK09009 309799004897 carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325 309799004898 NADP binding site [chemical binding]; other site 309799004899 homodimer interface [polypeptide binding]; other site 309799004900 active site 309799004901 Domain of unknown function (DUF1795); Region: DUF1795; cl02256 309799004902 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331 309799004903 TraB family; Region: TraB; pfam01963 309799004904 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 309799004905 Mechanosensitive ion channel; Region: MS_channel; pfam00924 309799004906 Rubrerythrin [Energy production and conversion]; Region: COG1592 309799004907 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 309799004908 binuclear metal center [ion binding]; other site 309799004909 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 309799004910 iron binding site [ion binding]; other site 309799004911 DOMON domain; Region: DOMON; pfam03351 309799004912 DOMON-like domain of copper-dependent monooxygenases and related proteins; Region: DOMON_DOH; cd09631 309799004913 putative ligand binding site [chemical binding]; other site 309799004914 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 309799004915 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 309799004916 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 309799004917 Walker A/P-loop; other site 309799004918 ATP binding site [chemical binding]; other site 309799004919 Q-loop/lid; other site 309799004920 ABC transporter signature motif; other site 309799004921 Walker B; other site 309799004922 D-loop; other site 309799004923 H-loop/switch region; other site 309799004924 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 309799004925 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 309799004926 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 309799004927 Walker A/P-loop; other site 309799004928 ATP binding site [chemical binding]; other site 309799004929 Q-loop/lid; other site 309799004930 ABC transporter signature motif; other site 309799004931 Walker B; other site 309799004932 D-loop; other site 309799004933 H-loop/switch region; other site 309799004934 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 309799004935 active site 309799004936 Protein of unknown function (DUF523); Region: DUF523; pfam04463 309799004937 Uncharacterized conserved protein [Function unknown]; Region: COG3272 309799004938 Protein of unknown function (DUF1722); Region: DUF1722; pfam08349 309799004939 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 309799004940 thiS-thiF/thiG interaction site; other site 309799004941 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 309799004942 ThiS interaction site; other site 309799004943 putative active site [active] 309799004944 tetramer interface [polypeptide binding]; other site 309799004945 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240 309799004946 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 309799004947 FeS/SAM binding site; other site 309799004948 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 309799004949 thiamine biosynthesis protein ThiF; Provisional; Region: PRK08644 309799004950 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196 309799004951 ATP binding site [chemical binding]; other site 309799004952 substrate interface [chemical binding]; other site 309799004953 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 309799004954 thiamine phosphate binding site [chemical binding]; other site 309799004955 active site 309799004956 pyrophosphate binding site [ion binding]; other site 309799004957 thiamine biosynthesis protein ThiC; Provisional; Region: PRK13352 309799004958 thiamine biosynthesis protein ThiC; Region: thiC; TIGR00190 309799004959 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 309799004960 dimer interface [polypeptide binding]; other site 309799004961 substrate binding site [chemical binding]; other site 309799004962 ATP binding site [chemical binding]; other site 309799004963 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 309799004964 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 309799004965 active site 309799004966 metal binding site [ion binding]; metal-binding site 309799004967 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 309799004968 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 309799004969 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 309799004970 TM-ABC transporter signature motif; other site 309799004971 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 309799004972 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 309799004973 Walker A/P-loop; other site 309799004974 ATP binding site [chemical binding]; other site 309799004975 Q-loop/lid; other site 309799004976 ABC transporter signature motif; other site 309799004977 Walker B; other site 309799004978 D-loop; other site 309799004979 H-loop/switch region; other site 309799004980 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 309799004981 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 309799004982 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 309799004983 ligand binding site [chemical binding]; other site 309799004984 SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate...; Region: SERPIN; cd00172 309799004985 reactive center loop; other site 309799004986 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 309799004987 Melibiase; Region: Melibiase; pfam02065 309799004988 Sulfur transfer protein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ThiS; COG2104 309799004989 charged pocket; other site 309799004990 hydrophobic patch; other site 309799004991 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 309799004992 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 309799004993 Ligand Binding Site [chemical binding]; other site 309799004994 TIGR00269 family protein; Region: TIGR00269 309799004995 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 309799004996 MPN+ (JAMM) motif; other site 309799004997 Zinc-binding site [ion binding]; other site 309799004998 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 309799004999 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 309799005000 FeS/SAM binding site; other site 309799005001 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 309799005002 trehalose synthase; Region: treS_nterm; TIGR02456 309799005003 Alpha amylase catalytic domain found in bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac2_AmyA; cd11316 309799005004 Ca binding site [ion binding]; other site 309799005005 active site 309799005006 catalytic site [active] 309799005007 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 309799005008 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 309799005009 nucleotide binding site [chemical binding]; other site 309799005010 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 309799005011 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 309799005012 NAD binding site [chemical binding]; other site 309799005013 sugar binding site [chemical binding]; other site 309799005014 divalent metal binding site [ion binding]; other site 309799005015 tetramer (dimer of dimers) interface [polypeptide binding]; other site 309799005016 dimer interface [polypeptide binding]; other site 309799005017 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Validated; Region: PRK05778 309799005018 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 309799005019 TPP-binding site [chemical binding]; other site 309799005020 Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367 309799005021 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 309799005022 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 309799005023 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 309799005024 dimer interface [polypeptide binding]; other site 309799005025 PYR/PP interface [polypeptide binding]; other site 309799005026 TPP binding site [chemical binding]; other site 309799005027 substrate binding site [chemical binding]; other site 309799005028 MarR family; Region: MarR_2; pfam12802 309799005029 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 309799005030 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 309799005031 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 309799005032 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 309799005033 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 309799005034 intersubunit interface [polypeptide binding]; other site 309799005035 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 309799005036 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 309799005037 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 309799005038 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 309799005039 ABC-ATPase subunit interface; other site 309799005040 dimer interface [polypeptide binding]; other site 309799005041 putative PBP binding regions; other site 309799005042 MarR family; Region: MarR_2; pfam12802 309799005043 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 309799005044 ROK family; Region: ROK; pfam00480 309799005045 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 309799005046 Ferritin-CCC1, N-terminal ferritin-like diiron-binding domain; Region: Ferritin_CCC1_N; cd01044 309799005047 diiron binding motif [ion binding]; other site 309799005048 CCC1-related domain of ferritin; Region: Ferritin_CCC1_C; cd02431 309799005049 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 309799005050 dimer interface [polypeptide binding]; other site 309799005051 [2Fe-2S] cluster binding site [ion binding]; other site 309799005052 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 309799005053 SLBB domain; Region: SLBB; pfam10531 309799005054 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 309799005055 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 309799005056 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 309799005057 putative dimer interface [polypeptide binding]; other site 309799005058 [2Fe-2S] cluster binding site [ion binding]; other site 309799005059 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 309799005060 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 309799005061 substrate binding pocket [chemical binding]; other site 309799005062 membrane-bound complex binding site; other site 309799005063 hinge residues; other site 309799005064 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 309799005065 GAF domain; Region: GAF_2; pfam13185 309799005066 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 309799005067 Zn2+ binding site [ion binding]; other site 309799005068 Mg2+ binding site [ion binding]; other site 309799005069 Protease prsW family; Region: PrsW-protease; pfam13367 309799005070 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 309799005071 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 309799005072 motif II; other site 309799005073 Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300 309799005074 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 309799005075 NAD binding site [chemical binding]; other site 309799005076 ligand binding site [chemical binding]; other site 309799005077 catalytic site [active] 309799005078 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 309799005079 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 309799005080 active site 309799005081 HIGH motif; other site 309799005082 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 309799005083 KMSKS motif; other site 309799005084 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 309799005085 tRNA binding surface [nucleotide binding]; other site 309799005086 anticodon binding site; other site 309799005087 CHASE4 domain; Region: CHASE4; cl01308 309799005088 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 309799005089 dimerization interface [polypeptide binding]; other site 309799005090 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 309799005091 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 309799005092 metal binding site [ion binding]; metal-binding site 309799005093 active site 309799005094 I-site; other site 309799005095 Xylose isomerase [Carbohydrate transport and metabolism]; Region: XylA; cl09945 309799005096 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 309799005097 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 309799005098 ATP cone domain; Region: ATP-cone; pfam03477 309799005099 Anaerobic ribonucleoside-triphosphate reductase; Region: NRDD; pfam13597 309799005100 Class III ribonucleotide reductase; Region: RNR_III; cd01675 309799005101 effector binding site; other site 309799005102 active site 309799005103 Zn binding site [ion binding]; other site 309799005104 glycine loop; other site 309799005105 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG2; TIGR02495 309799005106 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 309799005107 FeS/SAM binding site; other site 309799005108 Major Facilitator Superfamily; Region: MFS_1; pfam07690 309799005109 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 309799005110 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 309799005111 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 309799005112 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_4; cd08500 309799005113 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 309799005114 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 309799005115 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 309799005116 Walker A/P-loop; other site 309799005117 ATP binding site [chemical binding]; other site 309799005118 Q-loop/lid; other site 309799005119 ABC transporter signature motif; other site 309799005120 Walker B; other site 309799005121 D-loop; other site 309799005122 H-loop/switch region; other site 309799005123 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 309799005124 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 309799005125 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 309799005126 Walker A/P-loop; other site 309799005127 ATP binding site [chemical binding]; other site 309799005128 Q-loop/lid; other site 309799005129 ABC transporter signature motif; other site 309799005130 Walker B; other site 309799005131 D-loop; other site 309799005132 H-loop/switch region; other site 309799005133 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 309799005134 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 309799005135 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 309799005136 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 309799005137 putative PBP binding loops; other site 309799005138 ABC-ATPase subunit interface; other site 309799005139 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 309799005140 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 309799005141 dimer interface [polypeptide binding]; other site 309799005142 conserved gate region; other site 309799005143 putative PBP binding loops; other site 309799005144 ABC-ATPase subunit interface; other site 309799005145 Transcriptional regulators [Transcription]; Region: PurR; COG1609 309799005146 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 309799005147 DNA binding site [nucleotide binding] 309799005148 domain linker motif; other site 309799005149 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 309799005150 dimerization interface [polypeptide binding]; other site 309799005151 ligand binding site [chemical binding]; other site 309799005152 RNase_H superfamily; Region: RNase_H_2; pfam13482 309799005153 active site 309799005154 substrate binding site [chemical binding]; other site 309799005155 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 309799005156 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 309799005157 FeS/SAM binding site; other site 309799005158 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 309799005159 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 309799005160 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 309799005161 The URO-D _like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases. Uroporphyrinogen decarboxylase (URO-D) decarboxylates the four...; Region: URO-D_like; cd03465 309799005162 Alpha-glucuronidase [Carbohydrate transport and metabolism]; Region: AguA; COG3661 309799005163 Glycosyl hydrolase family 67 N-terminus; Region: Glyco_hydro_67N; pfam03648 309799005164 Glycosyl hydrolase family 67 C-terminus; Region: Glyco_hydro_67C; pfam07477 309799005165 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 309799005166 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 309799005167 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; pfam09723 309799005168 Uncharacterized Fe-S center protein [General function prediction only]; Region: COG2768 309799005169 Uncharacterized conserved protein [Function unknown]; Region: COG2006 309799005170 4Fe-4S binding domain; Region: Fer4; pfam00037 309799005171 4Fe-4S binding domain; Region: Fer4; pfam00037 309799005172 Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cl00019 309799005173 ADP-ribose binding site [chemical binding]; other site 309799005174 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 309799005175 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 309799005176 Walker A/P-loop; other site 309799005177 ATP binding site [chemical binding]; other site 309799005178 Q-loop/lid; other site 309799005179 ABC transporter signature motif; other site 309799005180 Walker B; other site 309799005181 D-loop; other site 309799005182 H-loop/switch region; other site 309799005183 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 309799005184 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 309799005185 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 309799005186 Walker A/P-loop; other site 309799005187 ATP binding site [chemical binding]; other site 309799005188 Q-loop/lid; other site 309799005189 ABC transporter signature motif; other site 309799005190 Walker B; other site 309799005191 D-loop; other site 309799005192 H-loop/switch region; other site 309799005193 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 309799005194 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 309799005195 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 309799005196 dimer interface [polypeptide binding]; other site 309799005197 conserved gate region; other site 309799005198 putative PBP binding loops; other site 309799005199 ABC-ATPase subunit interface; other site 309799005200 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 309799005201 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 309799005202 dimer interface [polypeptide binding]; other site 309799005203 conserved gate region; other site 309799005204 putative PBP binding loops; other site 309799005205 ABC-ATPase subunit interface; other site 309799005206 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 309799005207 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 309799005208 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 309799005209 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 309799005210 The substrate binding domain of a cellulose-binding protein from Thermotoga maritima contains the type 2 periplasmic binding fold; Region: PBP2_TmCBP_oligosaccharides_like; cd08509 309799005211 substrate binding site [chemical binding]; other site 309799005212 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 309799005213 Molybdenum cofactor biosynthesis enzyme [Coenzyme metabolism]; Region: MoaA; COG2896 309799005214 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 309799005215 FeS/SAM binding site; other site 309799005216 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 309799005217 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 309799005218 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 309799005219 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 309799005220 Uncharacterized conserved protein [Function unknown]; Region: COG0327 309799005221 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 309799005222 L-fucose isomerase and related proteins [Carbohydrate transport and metabolism]; Region: FucI; COG2407 309799005223 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 309799005224 hexamer (dimer of trimers) interface [polypeptide binding]; other site 309799005225 trimer interface [polypeptide binding]; other site 309799005226 substrate binding site [chemical binding]; other site 309799005227 Mn binding site [ion binding]; other site 309799005228 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 309799005229 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 309799005230 intersubunit interface [polypeptide binding]; other site 309799005231 active site 309799005232 Zn2+ binding site [ion binding]; other site 309799005233 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 309799005234 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 309799005235 Transcriptional regulators [Transcription]; Region: PurR; COG1609 309799005236 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 309799005237 DNA binding site [nucleotide binding] 309799005238 domain linker motif; other site 309799005239 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 309799005240 ligand binding site [chemical binding]; other site 309799005241 dimerization interface [polypeptide binding]; other site 309799005242 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; cl01412 309799005243 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; cl01412 309799005244 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 309799005245 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 309799005246 dimer interface [polypeptide binding]; other site 309799005247 conserved gate region; other site 309799005248 putative PBP binding loops; other site 309799005249 ABC-ATPase subunit interface; other site 309799005250 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 309799005251 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 309799005252 dimer interface [polypeptide binding]; other site 309799005253 ABC-ATPase subunit interface; other site 309799005254 putative PBP binding loops; other site 309799005255 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 309799005256 Glycosyl hydrolase family 43; Region: GH43_ABN_1; cd08998 309799005257 substrate binding site [chemical binding]; other site 309799005258 active site 309799005259 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 309799005260 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 309799005261 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 309799005262 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 309799005263 dimer interface [polypeptide binding]; other site 309799005264 conserved gate region; other site 309799005265 putative PBP binding loops; other site 309799005266 ABC-ATPase subunit interface; other site 309799005267 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 309799005268 dimer interface [polypeptide binding]; other site 309799005269 conserved gate region; other site 309799005270 ABC-ATPase subunit interface; other site 309799005271 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 309799005272 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 309799005273 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 309799005274 Transcriptional regulators [Transcription]; Region: PurR; COG1609 309799005275 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 309799005276 DNA binding site [nucleotide binding] 309799005277 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 309799005278 dimerization interface [polypeptide binding]; other site 309799005279 ligand binding site [chemical binding]; other site 309799005280 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 309799005281 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 309799005282 benzoyl-CoA reductase, bcr type, subunit B; Region: benz_CoA_red_B; TIGR02260 309799005283 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 309799005284 benzoyl-CoA reductase, subunit C; Region: benz_CoA_red_C; TIGR02263 309799005285 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 309799005286 ribulokinase; Provisional; Region: PRK04123 309799005287 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 309799005288 N- and C-terminal domain interface [polypeptide binding]; other site 309799005289 active site 309799005290 MgATP binding site [chemical binding]; other site 309799005291 catalytic site [active] 309799005292 metal binding site [ion binding]; metal-binding site 309799005293 carbohydrate binding site [chemical binding]; other site 309799005294 homodimer interface [polypeptide binding]; other site 309799005295 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 309799005296 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 309799005297 NAD binding site [chemical binding]; other site 309799005298 sugar binding site [chemical binding]; other site 309799005299 divalent metal binding site [ion binding]; other site 309799005300 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 309799005301 dimer interface [polypeptide binding]; other site 309799005302 Membrane transport protein; Region: Mem_trans; cl09117 309799005303 Glycerol-1-phosphate dehydrogenase (G1PDH) catalyzes the reversible reduction of dihydroxyacetone phosphate (DHAP) to glycerol-1-phosphate (G1P) in an NADH-dependent manner; Region: G1PDH; cd08175 309799005304 active site 309799005305 metal binding site [ion binding]; metal-binding site 309799005306 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 309799005307 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 309799005308 ligand binding site [chemical binding]; other site 309799005309 dimerization interface [polypeptide binding]; other site 309799005310 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 309799005311 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 309799005312 metal binding site [ion binding]; metal-binding site 309799005313 active site 309799005314 I-site; other site 309799005315 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 309799005316 dimerization interface [polypeptide binding]; other site 309799005317 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 309799005318 ligand binding site [chemical binding]; other site 309799005319 GAF domain; Region: GAF_2; pfam13185 309799005320 GAF domain; Region: GAF_3; pfam13492 309799005321 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 309799005322 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 309799005323 metal binding site [ion binding]; metal-binding site 309799005324 active site 309799005325 I-site; other site 309799005326 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 309799005327 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 309799005328 Zn2+ binding site [ion binding]; other site 309799005329 Mg2+ binding site [ion binding]; other site 309799005330 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 309799005331 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 309799005332 dimer interface [polypeptide binding]; other site 309799005333 active site 309799005334 metal binding site [ion binding]; metal-binding site 309799005335 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 309799005336 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 309799005337 substrate binding site [chemical binding]; other site 309799005338 THF binding site; other site 309799005339 zinc-binding site [ion binding]; other site 309799005340 methionine synthase; Provisional; Region: PRK01207 309799005341 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 309799005342 substrate binding site [chemical binding]; other site 309799005343 THF binding site; other site 309799005344 zinc-binding site [ion binding]; other site 309799005345 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 309799005346 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 309799005347 metal binding site [ion binding]; metal-binding site 309799005348 active site 309799005349 I-site; other site 309799005350 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 309799005351 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 309799005352 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 309799005353 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 309799005354 Major Facilitator Superfamily; Region: MFS_1; pfam07690 309799005355 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 309799005356 putative substrate translocation pore; other site 309799005357 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 309799005358 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 309799005359 Walker A/P-loop; other site 309799005360 ATP binding site [chemical binding]; other site 309799005361 Q-loop/lid; other site 309799005362 ABC transporter signature motif; other site 309799005363 Walker B; other site 309799005364 D-loop; other site 309799005365 H-loop/switch region; other site 309799005366 cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454 309799005367 PDGLE domain; Region: PDGLE; pfam13190 309799005368 cobalt transport protein CbiM; Provisional; Region: PRK11909 309799005369 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 309799005370 nickel responsive regulator; Provisional; Region: PRK04460 309799005371 NikR C terminal nickel binding domain; Region: NikR_C; pfam08753 309799005372 ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606 309799005373 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 309799005374 Ligand Binding Site [chemical binding]; other site 309799005375 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 309799005376 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 309799005377 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 309799005378 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 309799005379 classical (c) SDRs; Region: SDR_c; cd05233 309799005380 NAD(P) binding site [chemical binding]; other site 309799005381 active site 309799005382 DctM-like transporters; Region: DctM; pfam06808 309799005383 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 309799005384 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 309799005385 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 309799005386 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 309799005387 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 309799005388 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_2; cd12172 309799005389 putative ligand binding site [chemical binding]; other site 309799005390 putative NAD binding site [chemical binding]; other site 309799005391 catalytic site [active] 309799005392 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 309799005393 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 309799005394 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 309799005395 putative active site [active] 309799005396 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 309799005397 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 309799005398 Repressor of nif and glnA expression [Transcription]; Region: COG1693 309799005399 Ribonuclease R winged-helix domain; Region: HTH_12; pfam08461 309799005400 Domain of unknown function DUF128; Region: DUF128; pfam01995 309799005401 argininosuccinate lyase; Provisional; Region: PRK00855 309799005402 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 309799005403 active sites [active] 309799005404 tetramer interface [polypeptide binding]; other site 309799005405 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 309799005406 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 309799005407 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 309799005408 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 309799005409 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 309799005410 ATP-grasp domain; Region: ATP-grasp_4; cl17255 309799005411 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 309799005412 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 309799005413 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 309799005414 catalytic site [active] 309799005415 subunit interface [polypeptide binding]; other site 309799005416 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 309799005417 acetylornithine aminotransferase; Provisional; Region: PRK02627 309799005418 inhibitor-cofactor binding pocket; inhibition site 309799005419 pyridoxal 5'-phosphate binding site [chemical binding]; other site 309799005420 catalytic residue [active] 309799005421 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 309799005422 heterotetramer interface [polypeptide binding]; other site 309799005423 active site pocket [active] 309799005424 cleavage site 309799005425 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 309799005426 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 309799005427 argininosuccinate synthase; Provisional; Region: PRK13820 309799005428 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 309799005429 ANP binding site [chemical binding]; other site 309799005430 Substrate Binding Site II [chemical binding]; other site 309799005431 Substrate Binding Site I [chemical binding]; other site 309799005432 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 309799005433 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 309799005434 phosphopeptide binding site; other site 309799005435 CHASE2 domain; Region: CHASE2; pfam05226 309799005436 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 309799005437 Catalytic domain of Protein Kinases; Region: PKc; cd00180 309799005438 active site 309799005439 ATP binding site [chemical binding]; other site 309799005440 substrate binding site [chemical binding]; other site 309799005441 activation loop (A-loop); other site 309799005442 ornithine carbamoyltransferase; Provisional; Region: PRK00779 309799005443 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 309799005444 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 309799005445 Major Facilitator Superfamily; Region: MFS_1; pfam07690 309799005446 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 309799005447 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 309799005448 Predicted permeases [General function prediction only]; Region: COG0679 309799005449 Protein of unknown function (DUF401); Region: DUF401; cl00830 309799005450 Protein of unknown function (DUF401); Region: DUF401; cl00830 309799005451 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 309799005452 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 309799005453 active site 309799005454 metal binding site [ion binding]; metal-binding site 309799005455 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 309799005456 pyruvate kinase; Provisional; Region: PRK06354 309799005457 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 309799005458 domain interfaces; other site 309799005459 active site 309799005460 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 309799005461 Septum formation initiator; Region: DivIC; cl17659 309799005462 Predicted DNA-binding protein with the Helix-hairpin-helix motif [General function prediction only]; Region: COG4277 309799005463 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 309799005464 FeS/SAM binding site; other site 309799005465 Helix-hairpin-helix motif; Region: HHH; pfam00633 309799005466 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 309799005467 beta-galactosidase; Region: BGL; TIGR03356 309799005468 Domain of unknown function (DUF377); Region: DUF377; pfam04041 309799005469 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 309799005470 active site 309799005471 Peptidase family M54, also called archaemetzincins or archaelysins; Region: Peptidase_M54; cd11375 309799005472 active site 309799005473 Zn binding site [ion binding]; other site 309799005474 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 309799005475 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 309799005476 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 309799005477 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 309799005478 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 309799005479 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 309799005480 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 309799005481 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 309799005482 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 309799005483 nucleotide binding site [chemical binding]; other site 309799005484 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 309799005485 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 309799005486 active site 309799005487 catalytic tetrad [active] 309799005488 Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293 309799005489 Domain of unknown function (DUF814); Region: DUF814; pfam05670 309799005490 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 309799005491 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 309799005492 active site 309799005493 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 309799005494 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 309799005495 ligand binding site [chemical binding]; other site 309799005496 flexible hinge region; other site 309799005497 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 309799005498 putative switch regulator; other site 309799005499 non-specific DNA interactions [nucleotide binding]; other site 309799005500 DNA binding site [nucleotide binding] 309799005501 sequence specific DNA binding site [nucleotide binding]; other site 309799005502 putative cAMP binding site [chemical binding]; other site 309799005503 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 309799005504 DnaA N-terminal domain; Region: DnaA_N; pfam11638 309799005505 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 309799005506 Walker A motif; other site 309799005507 ATP binding site [chemical binding]; other site 309799005508 Walker B motif; other site 309799005509 arginine finger; other site 309799005510 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 309799005511 DnaA box-binding interface [nucleotide binding]; other site 309799005512 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 309799005513 HflC protein; Region: hflC; TIGR01932 309799005514 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 309799005515 HflK protein; Region: hflK; TIGR01933 309799005516 Transcription factor zinc-finger; Region: zf-TFIIB; pfam13453 309799005517 Domain of unknown function (DUF4384); Region: DUF4384; pfam14326 309799005518 PEGA domain; Region: PEGA; pfam08308 309799005519 PEGA domain; Region: PEGA; pfam08308 309799005520 PEGA domain; Region: PEGA; pfam08308 309799005521 PEGA domain; Region: PEGA; pfam08308 309799005522 PEGA domain; Region: PEGA; pfam08308 309799005523 PAS fold; Region: PAS_4; pfam08448 309799005524 GAF domain; Region: GAF_2; pfam13185 309799005525 GAF domain; Region: GAF_3; pfam13492 309799005526 PAS domain S-box; Region: sensory_box; TIGR00229 309799005527 PAS domain; Region: PAS_8; pfam13188 309799005528 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 309799005529 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 309799005530 metal binding site [ion binding]; metal-binding site 309799005531 active site 309799005532 I-site; other site 309799005533 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: PhosphMutase; cl17294 309799005534 cofactor-independent phosphoglycerate mutase; Provisional; Region: PRK04200 309799005535 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 309799005536 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 309799005537 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 309799005538 catalytic residue [active] 309799005539 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 309799005540 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 309799005541 trimerization site [polypeptide binding]; other site 309799005542 active site 309799005543 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 309799005544 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 309799005545 ABC transporter signature motif; other site 309799005546 Walker B; other site 309799005547 D-loop; other site 309799005548 H-loop/switch region; other site 309799005549 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 309799005550 Ferritin-like domain; Region: Ferritin; pfam00210 309799005551 dinuclear metal binding motif [ion binding]; other site 309799005552 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 309799005553 catalytic triad [active] 309799005554 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 309799005555 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 309799005556 reverse gyrase; Reviewed; Region: PRK09401 309799005557 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 309799005558 ATP binding site [chemical binding]; other site 309799005559 putative Mg++ binding site [ion binding]; other site 309799005560 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 309799005561 nucleotide binding region [chemical binding]; other site 309799005562 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 309799005563 active site 309799005564 metal binding site [ion binding]; metal-binding site 309799005565 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 309799005566 domain I; other site 309799005567 DNA binding groove [nucleotide binding] 309799005568 phosphate binding site [ion binding]; other site 309799005569 domain II; other site 309799005570 domain III; other site 309799005571 nucleotide binding site [chemical binding]; other site 309799005572 catalytic site [active] 309799005573 domain IV; other site 309799005574 recombination protein F; Reviewed; Region: recF; PRK00064 309799005575 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 309799005576 Walker A/P-loop; other site 309799005577 ATP binding site [chemical binding]; other site 309799005578 Q-loop/lid; other site 309799005579 ABC transporter signature motif; other site 309799005580 Walker B; other site 309799005581 D-loop; other site 309799005582 GrpE; Region: GrpE; pfam01025 309799005583 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 309799005584 dimer interface [polypeptide binding]; other site 309799005585 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 309799005586 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 309799005587 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 309799005588 nucleotide binding site [chemical binding]; other site 309799005589 NEF interaction site [polypeptide binding]; other site 309799005590 SBD interface [polypeptide binding]; other site 309799005591 chaperone protein DnaJ; Region: DnaJ_bact; TIGR02349 309799005592 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 309799005593 HSP70 interaction site [polypeptide binding]; other site 309799005594 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 309799005595 substrate binding site [polypeptide binding]; other site 309799005596 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 309799005597 Zn binding sites [ion binding]; other site 309799005598 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 309799005599 dimer interface [polypeptide binding]; other site 309799005600 Protein of unknown function DUF86; Region: DUF86; cl01031 309799005601 LexA repressor; Validated; Region: PRK00215 309799005602 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 309799005603 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 309799005604 Catalytic site [active] 309799005605 Predicted dehydrogenase [General function prediction only]; Region: COG0579 309799005606 hydroxyglutarate oxidase; Provisional; Region: PRK11728 309799005607 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 309799005608 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 309799005609 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cd00368 309799005610 Protein of unknown function (DUF1667); Region: DUF1667; pfam07892 309799005611 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 309799005612 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 309799005613 dimer interface [polypeptide binding]; other site 309799005614 pyridoxal 5'-phosphate binding site [chemical binding]; other site 309799005615 catalytic residue [active] 309799005616 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 309799005617 Uridine monophosphate kinase_like (UMPK_like) is a family of proteins highly similar to the uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK); Region: UMPK_like; cd02028 309799005618 active site 309799005619 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 309799005620 oligomerisation interface [polypeptide binding]; other site 309799005621 mobile loop; other site 309799005622 roof hairpin; other site 309799005623 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 309799005624 catalytic residues [active] 309799005625 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 309799005626 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 309799005627 intersubunit interface [polypeptide binding]; other site 309799005628 active site 309799005629 zinc binding site [ion binding]; other site 309799005630 Na+ binding site [ion binding]; other site 309799005631 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 309799005632 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 309799005633 AP (apurinic/apyrimidinic) site pocket; other site 309799005634 DNA interaction; other site 309799005635 Metal-binding active site; metal-binding site 309799005636 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 309799005637 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 309799005638 homodimer interface [polypeptide binding]; other site 309799005639 Walker A motif; other site 309799005640 ATP binding site [chemical binding]; other site 309799005641 hydroxycobalamin binding site [chemical binding]; other site 309799005642 Walker B motif; other site 309799005643 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 309799005644 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 309799005645 ligand binding site [chemical binding]; other site 309799005646 NAD binding site [chemical binding]; other site 309799005647 dimerization interface [polypeptide binding]; other site 309799005648 catalytic site [active] 309799005649 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 309799005650 putative L-serine binding site [chemical binding]; other site 309799005651 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451 309799005652 homodimer interface [polypeptide binding]; other site 309799005653 pyridoxal 5'-phosphate binding site [chemical binding]; other site 309799005654 catalytic residue [active] 309799005655 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 309799005656 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 309799005657 trimer interface [polypeptide binding]; other site 309799005658 putative metal binding site [ion binding]; other site 309799005659 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 309799005660 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 309799005661 Peptidase family M23; Region: Peptidase_M23; pfam01551 309799005662 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 309799005663 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 309799005664 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 309799005665 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 309799005666 Protein of unknown function DUF58; Region: DUF58; pfam01882 309799005667 MoxR-like ATPases [General function prediction only]; Region: COG0714 309799005668 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 309799005669 Walker A motif; other site 309799005670 ATP binding site [chemical binding]; other site 309799005671 Walker B motif; other site 309799005672 arginine finger; other site 309799005673 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 309799005674 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 309799005675 DNA binding residues [nucleotide binding] 309799005676 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 309799005677 trimer interface [polypeptide binding]; other site 309799005678 active site 309799005679 Domain of unknown function (DUF4380); Region: DUF4380; pfam14315 309799005680 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 309799005681 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 309799005682 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 309799005683 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 309799005684 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 309799005685 active site 309799005686 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 309799005687 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 309799005688 Substrate binding site; other site 309799005689 Cupin domain; Region: Cupin_2; cl17218 309799005690 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 309799005691 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 309799005692 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 309799005693 PhoU domain; Region: PhoU; pfam01895 309799005694 PhoU domain; Region: PhoU; pfam01895 309799005695 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 309799005696 extended (e) SDRs; Region: SDR_e; cd08946 309799005697 NAD(P) binding site [chemical binding]; other site 309799005698 active site 309799005699 substrate binding site [chemical binding]; other site 309799005700 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 309799005701 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 309799005702 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 309799005703 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 309799005704 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 309799005705 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 309799005706 Walker A/P-loop; other site 309799005707 ATP binding site [chemical binding]; other site 309799005708 Q-loop/lid; other site 309799005709 ABC transporter signature motif; other site 309799005710 Walker B; other site 309799005711 D-loop; other site 309799005712 H-loop/switch region; other site 309799005713 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 309799005714 ABC-2 type transporter; Region: ABC2_membrane; cl17235 309799005715 Predicted transcriptional regulator [Transcription]; Region: COG2378 309799005716 WYL domain; Region: WYL; pfam13280 309799005717 competence damage-inducible protein A; Provisional; Region: PRK00549 309799005718 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 309799005719 putative MPT binding site; other site 309799005720 Competence-damaged protein; Region: CinA; pfam02464 309799005721 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 309799005722 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 309799005723 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 309799005724 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 309799005725 Zn2+ binding site [ion binding]; other site 309799005726 Mg2+ binding site [ion binding]; other site 309799005727 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 309799005728 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 309799005729 metal binding site [ion binding]; metal-binding site 309799005730 dimer interface [polypeptide binding]; other site 309799005731 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 309799005732 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 309799005733 active site 309799005734 substrate binding site [chemical binding]; other site 309799005735 metal binding site [ion binding]; metal-binding site 309799005736 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 309799005737 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 309799005738 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 309799005739 DNA binding residues [nucleotide binding] 309799005740 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 309799005741 transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283 309799005742 active site 309799005743 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; pfam02660 309799005744 Dolichol kinase [Lipid metabolism]; Region: SEC59; COG0170 309799005745 N-terminal putative catalytic domain of uncharacterized HKD family nucleases fused to putative helicases from the Snf2-like family; Region: PLDc_N_Snf2_like; cd09178 309799005746 PLD-like domain; Region: PLDc_2; pfam13091 309799005747 putative homodimer interface [polypeptide binding]; other site 309799005748 putative active site [active] 309799005749 catalytic site [active] 309799005750 DEAD-like helicases superfamily; Region: DEXDc; smart00487 309799005751 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 309799005752 ATP binding site [chemical binding]; other site 309799005753 putative Mg++ binding site [ion binding]; other site 309799005754 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 309799005755 nucleotide binding region [chemical binding]; other site 309799005756 ATP-binding site [chemical binding]; other site 309799005757 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 309799005758 TaqI-like C-terminal specificity domain; Region: TaqI_C; pfam12950 309799005759 FlxA-like protein; Region: FlxA; pfam14282 309799005760 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 309799005761 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 309799005762 hydrogenase nickel incorporation protein; Provisional; Region: hypA; PRK03824 309799005763 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 309799005764 AAA domain; Region: AAA_31; pfam13614 309799005765 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 309799005766 Walker A motif; other site 309799005767 bidirectional hydrogenase complex protein HoxU; Validated; Region: PRK07569 309799005768 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 309799005769 catalytic loop [active] 309799005770 iron binding site [ion binding]; other site 309799005771 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 309799005772 4Fe-4S binding domain; Region: Fer4; pfam00037 309799005773 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 309799005774 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cd00368 309799005775 molybdopterin cofactor binding site; other site 309799005776 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 309799005777 Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259 309799005778 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 309799005779 Hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). These enzymes belong to the peptidase family M52. Maturation of [FeNi] hydrogenases includes formation of the nickel metallocenter, proteolytic processing...; Region: H2MP; cl00477 309799005780 nickel binding site [ion binding]; other site 309799005781 Acylphosphatase; Region: Acylphosphatase; pfam00708 309799005782 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 309799005783 HypF finger; Region: zf-HYPF; pfam07503 309799005784 HypF finger; Region: zf-HYPF; pfam07503 309799005785 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 309799005786 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 309799005787 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 309799005788 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 309799005789 Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; pfam09719 309799005790 HupF/HypC family; Region: HupF_HypC; pfam01455 309799005791 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 309799005792 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 309799005793 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 309799005794 dimerization interface [polypeptide binding]; other site 309799005795 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 309799005796 ATP binding site [chemical binding]; other site 309799005797 Glycosyl hydrolase family 43; Region: GH43_AXH_1; cd09003 309799005798 substrate binding site [chemical binding]; other site 309799005799 active site 309799005800 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 309799005801 metal binding site [ion binding]; metal-binding site 309799005802 ligand binding site [chemical binding]; other site 309799005803 Glycosyl hydrolases family 39; Region: Glyco_hydro_39; pfam01229 309799005804 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 309799005805 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 309799005806 Uncharacterized conserved protein [Function unknown]; Region: COG2006 309799005807 Domain of unknown function (DUF362); Region: DUF362; pfam04015 309799005808 4Fe-4S binding domain; Region: Fer4; pfam00037 309799005809 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 309799005810 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 309799005811 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 309799005812 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 309799005813 ABC-2 type transporter; Region: ABC2_membrane; cl17235 309799005814 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 309799005815 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 309799005816 Walker A/P-loop; other site 309799005817 ATP binding site [chemical binding]; other site 309799005818 Q-loop/lid; other site 309799005819 ABC transporter signature motif; other site 309799005820 Walker B; other site 309799005821 D-loop; other site 309799005822 H-loop/switch region; other site 309799005823 DpnII restriction endonuclease; Region: DpnII; pfam04556 309799005824 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 309799005825 S-adenosylmethionine binding site [chemical binding]; other site 309799005826 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 309799005827 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 309799005828 RNA binding surface [nucleotide binding]; other site 309799005829 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 309799005830 active site 309799005831 uracil binding [chemical binding]; other site 309799005832 Glycoside hydrolase family 44; Region: Glyco_hydro_44; pfam12891 309799005833 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 309799005834 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 309799005835 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 309799005836 Uncharacterized conserved protein [Function unknown]; Region: COG2445 309799005837 H+ Antiporter protein; Region: 2A0121; TIGR00900 309799005838 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 309799005839 putative substrate translocation pore; other site 309799005840 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 309799005841 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 309799005842 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 309799005843 Walker A/P-loop; other site 309799005844 ATP binding site [chemical binding]; other site 309799005845 Q-loop/lid; other site 309799005846 ABC transporter signature motif; other site 309799005847 Walker B; other site 309799005848 D-loop; other site 309799005849 Uncharacterized conserved protein [Function unknown]; Region: COG2445 309799005850 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 309799005851 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 309799005852 Walker A/P-loop; other site 309799005853 ATP binding site [chemical binding]; other site 309799005854 Q-loop/lid; other site 309799005855 ABC transporter signature motif; other site 309799005856 Walker B; other site 309799005857 D-loop; other site 309799005858 H-loop/switch region; other site 309799005859 Radical SAM superfamily; Region: Radical_SAM; pfam04055 309799005860 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 309799005861 FeS/SAM binding site; other site 309799005862 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 309799005863 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 309799005864 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 309799005865 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 309799005866 FeS/SAM binding site; other site 309799005867 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 309799005868 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 309799005869 active site 309799005870 NTP binding site [chemical binding]; other site 309799005871 metal binding triad [ion binding]; metal-binding site 309799005872 antibiotic binding site [chemical binding]; other site 309799005873 Uncharacterized conserved protein [Function unknown]; Region: COG2361 309799005874 MjaI restriction endonuclease; Region: RE_MjaI; pfam09568 309799005875 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 309799005876 Beta/Gamma crystallin; Region: Crystall; cl02528 309799005877 Beta/Gamma crystallin; Region: Crystall; cl02528 309799005878 Beta/Gamma crystallin; Region: Crystall; cl02528 309799005879 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 309799005880 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915 309799005881 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 309799005882 Cl- selectivity filter; other site 309799005883 Cl- binding residues [ion binding]; other site 309799005884 pore gating glutamate residue; other site 309799005885 dimer interface [polypeptide binding]; other site 309799005886 Bacitracin resistance protein BacA; Region: BacA; pfam02673 309799005887 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 309799005888 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 309799005889 trmE is a tRNA modification GTPase; Region: trmE; cd04164 309799005890 G1 box; other site 309799005891 GTP/Mg2+ binding site [chemical binding]; other site 309799005892 Switch I region; other site 309799005893 G2 box; other site 309799005894 Switch II region; other site 309799005895 G3 box; other site 309799005896 G4 box; other site 309799005897 G5 box; other site 309799005898 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 309799005899 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 309799005900 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 309799005901 G-X-X-G motif; other site 309799005902 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 309799005903 RxxxH motif; other site 309799005904 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 309799005905 Haemolytic domain; Region: Haemolytic; pfam01809 309799005906 ribonuclease P; Reviewed; Region: rnpA; PRK00499 309799005907 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 309799005908 nicotinate phosphoribosyltransferase; Reviewed; Region: PRK08662 309799005909 Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an important role in NAD production by either allowing quinolinic acid (QA) , quinolinate phosphoribosyl transferase (QAPRTase), or nicotinic acid (NA), nicotinate...; Region: PRTase_typeII; cl17275 309799005910 active site 309799005911 Isochorismatase family; Region: Isochorismatase; pfam00857 309799005912 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 309799005913 catalytic triad [active] 309799005914 conserved cis-peptide bond; other site 309799005915 Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894 309799005916 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 309799005917 hypothetical protein; Reviewed; Region: PRK09588 309799005918 F plasmid transfer operon, TraF, protein; Region: TraF_2; pfam13729 309799005919 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 309799005920 Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; cl00852 309799005921 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 309799005922 gamma subunit interface [polypeptide binding]; other site 309799005923 LBP interface [polypeptide binding]; other site 309799005924 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 309799005925 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 309799005926 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 309799005927 alpha subunit interaction interface [polypeptide binding]; other site 309799005928 Walker A motif; other site 309799005929 ATP binding site [chemical binding]; other site 309799005930 Walker B motif; other site 309799005931 inhibitor binding site; inhibition site 309799005932 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 309799005933 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 309799005934 core domain interface [polypeptide binding]; other site 309799005935 delta subunit interface [polypeptide binding]; other site 309799005936 epsilon subunit interface [polypeptide binding]; other site 309799005937 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 309799005938 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 309799005939 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 309799005940 Walker A motif; other site 309799005941 ATP binding site [chemical binding]; other site 309799005942 Walker B motif; other site 309799005943 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 309799005944 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 309799005945 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 309799005946 F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; cl17210 309799005947 ATP synthase subunit C; Region: ATP-synt_C; cl00466 309799005948 ATP synthase A chain; Region: ATP-synt_A; cl00413 309799005949 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527 309799005950 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 309799005951 Yqey-like protein; Region: YqeY; cl17540 309799005952 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 309799005953 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 309799005954 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 309799005955 active site 309799005956 Zn binding site [ion binding]; other site 309799005957 Uncharacterized conserved protein [Function unknown]; Region: COG1739 309799005958 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 309799005959 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 309799005960 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 309799005961 protein binding site [polypeptide binding]; other site 309799005962 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 309799005963 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 309799005964 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 309799005965 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 309799005966 Rubredoxin [Energy production and conversion]; Region: COG1773 309799005967 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 309799005968 iron binding site [ion binding]; other site 309799005969 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 309799005970 Predicted permeases [General function prediction only]; Region: COG0795 309799005971 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 309799005972 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 309799005973 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 309799005974 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 309799005975 putative active site [active] 309799005976 catalytic triad [active] 309799005977 putative dimer interface [polypeptide binding]; other site 309799005978 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 309799005979 HAMP domain; Region: HAMP; pfam00672 309799005980 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 309799005981 dimer interface [polypeptide binding]; other site 309799005982 phosphorylation site [posttranslational modification] 309799005983 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 309799005984 ATP binding site [chemical binding]; other site 309799005985 Mg2+ binding site [ion binding]; other site 309799005986 G-X-G motif; other site 309799005987 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 309799005988 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 309799005989 active site 309799005990 phosphorylation site [posttranslational modification] 309799005991 intermolecular recognition site; other site 309799005992 dimerization interface [polypeptide binding]; other site 309799005993 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 309799005994 DNA binding site [nucleotide binding] 309799005995 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 309799005996 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 309799005997 active site 309799005998 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 309799005999 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 309799006000 NAD binding site [chemical binding]; other site 309799006001 sugar binding site [chemical binding]; other site 309799006002 divalent metal binding site [ion binding]; other site 309799006003 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 309799006004 dimer interface [polypeptide binding]; other site 309799006005 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 309799006006 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 309799006007 Walker A/P-loop; other site 309799006008 ATP binding site [chemical binding]; other site 309799006009 Q-loop/lid; other site 309799006010 ABC transporter signature motif; other site 309799006011 Walker B; other site 309799006012 D-loop; other site 309799006013 H-loop/switch region; other site 309799006014 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 309799006015 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 309799006016 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 309799006017 Walker A/P-loop; other site 309799006018 ATP binding site [chemical binding]; other site 309799006019 Q-loop/lid; other site 309799006020 ABC transporter signature motif; other site 309799006021 Walker B; other site 309799006022 D-loop; other site 309799006023 H-loop/switch region; other site 309799006024 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 309799006025 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 309799006026 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 309799006027 dimer interface [polypeptide binding]; other site 309799006028 conserved gate region; other site 309799006029 putative PBP binding loops; other site 309799006030 ABC-ATPase subunit interface; other site 309799006031 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 309799006032 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 309799006033 dimer interface [polypeptide binding]; other site 309799006034 conserved gate region; other site 309799006035 putative PBP binding loops; other site 309799006036 ABC-ATPase subunit interface; other site 309799006037 The substrate binding domain of a cellulose-binding protein from Thermotoga maritima contains the type 2 periplasmic binding fold; Region: PBP2_TmCBP_oligosaccharides_like; cd08509 309799006038 substrate binding site [chemical binding]; other site 309799006039 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 309799006040 Transcriptional regulators [Transcription]; Region: PurR; COG1609 309799006041 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 309799006042 DNA binding site [nucleotide binding] 309799006043 domain linker motif; other site 309799006044 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 309799006045 dimerization interface [polypeptide binding]; other site 309799006046 ligand binding site [chemical binding]; other site 309799006047 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4370 309799006048 conserved hypothetical protein; Region: TIGR03492 309799006049 Domain of unknown function (DUF4272); Region: DUF4272; pfam14094 309799006050 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 309799006051 iron-containing alcohol dehydrogenases (Fe-ADH)-like; Region: Fe-ADH; cd08551 309799006052 active site 309799006053 metal binding site [ion binding]; metal-binding site 309799006054 Cytidylate kinase-like family; Region: Cytidylate_kin2; pfam13189 309799006055 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 309799006056 active site 309799006057 Predicted transcriptional regulators [Transcription]; Region: COG1695 309799006058 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 309799006059 putative alpha-glucosidase; Provisional; Region: PRK10658 309799006060 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 309799006061 Alpha-glucosidase II (alpha-D-glucoside glucohydrolase) is a glycosyl hydrolase family 31 (GH31) enzyme, found in bacteria and plants, which has exo-alpha-1,4-glucosidase and oligo-1,6-glucosidase activities. Alpha-glucosidase II has been characterized...; Region: GH31_glucosidase_II_MalA; cd06604 309799006062 trimer interface [polypeptide binding]; other site 309799006063 active site 309799006064 homohexamer (dimer of homotrimer) interface [polypeptide binding]; other site 309799006065 catalytic site [active] 309799006066 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 309799006067 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 309799006068 sugar binding site [chemical binding]; other site 309799006069 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 309799006070 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 309799006071 dimer interface [polypeptide binding]; other site 309799006072 conserved gate region; other site 309799006073 putative PBP binding loops; other site 309799006074 ABC-ATPase subunit interface; other site 309799006075 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 309799006076 dimer interface [polypeptide binding]; other site 309799006077 conserved gate region; other site 309799006078 putative PBP binding loops; other site 309799006079 ABC-ATPase subunit interface; other site 309799006080 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 309799006081 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 309799006082 Transcriptional regulators [Transcription]; Region: PurR; COG1609 309799006083 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 309799006084 DNA binding site [nucleotide binding] 309799006085 domain linker motif; other site 309799006086 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 309799006087 dimerization interface [polypeptide binding]; other site 309799006088 ligand binding site [chemical binding]; other site 309799006089 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 309799006090 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 309799006091 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 309799006092 Peptidase family M48; Region: Peptidase_M48; pfam01435 309799006093 NAD synthetase; Provisional; Region: PRK13981 309799006094 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 309799006095 multimer interface [polypeptide binding]; other site 309799006096 active site 309799006097 catalytic triad [active] 309799006098 protein interface 1 [polypeptide binding]; other site 309799006099 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 309799006100 homodimer interface [polypeptide binding]; other site 309799006101 NAD binding pocket [chemical binding]; other site 309799006102 ATP binding pocket [chemical binding]; other site 309799006103 Mg binding site [ion binding]; other site 309799006104 active-site loop [active] 309799006105 transketolase; Reviewed; Region: PRK05899 309799006106 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 309799006107 TPP-binding site [chemical binding]; other site 309799006108 dimer interface [polypeptide binding]; other site 309799006109 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 309799006110 PYR/PP interface [polypeptide binding]; other site 309799006111 dimer interface [polypeptide binding]; other site 309799006112 TPP binding site [chemical binding]; other site 309799006113 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 309799006114 histidinol-phosphatase; Provisional; Region: PRK07328 309799006115 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 309799006116 active site 309799006117 dimer interface [polypeptide binding]; other site 309799006118 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 309799006119 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 309799006120 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 309799006121 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 309799006122 putative dimer interface [polypeptide binding]; other site 309799006123 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 309799006124 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 309799006125 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 309799006126 Chromate transporter; Region: Chromate_transp; pfam02417 309799006127 Chromate transporter; Region: Chromate_transp; pfam02417 309799006128 Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_12; cd12177 309799006129 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 309799006130 putative ligand binding site [chemical binding]; other site 309799006131 putative NAD binding site [chemical binding]; other site 309799006132 catalytic site [active] 309799006133 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 309799006134 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 309799006135 N- and C-terminal domain interface [polypeptide binding]; other site 309799006136 active site 309799006137 catalytic site [active] 309799006138 metal binding site [ion binding]; metal-binding site 309799006139 carbohydrate binding site [chemical binding]; other site 309799006140 ATP binding site [chemical binding]; other site 309799006141 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 309799006142 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 309799006143 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 309799006144 D-mannonate oxidoreductase; Provisional; Region: PRK08277 309799006145 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 309799006146 NAD(P) binding site [chemical binding]; other site 309799006147 active site 309799006148 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432 309799006149 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 309799006150 active site 309799006151 Major Facilitator Superfamily; Region: MFS_1; pfam07690 309799006152 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 309799006153 putative substrate translocation pore; other site 309799006154 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 309799006155 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 309799006156 active site 309799006157 catalytic site [active] 309799006158 N-glycosylase/DNA lyase; Provisional; Region: PRK01229 309799006159 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 309799006160 minor groove reading motif; other site 309799006161 helix-hairpin-helix signature motif; other site 309799006162 substrate binding pocket [chemical binding]; other site 309799006163 active site 309799006164 Sugar fermentation stimulation protein; Region: SfsA; cl00647 309799006165 phosphate ABC transporter, phosphate-binding protein; Region: 3a0107s03; TIGR00975 309799006166 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 309799006167 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 309799006168 Major Facilitator Superfamily; Region: MFS_1; pfam07690 309799006169 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 309799006170 dinuclear metal binding motif [ion binding]; other site 309799006171 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 309799006172 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 309799006173 P-loop; other site 309799006174 Magnesium ion binding site [ion binding]; other site 309799006175 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 309799006176 Magnesium ion binding site [ion binding]; other site 309799006177 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 309799006178 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 309799006179 ParB-like nuclease domain; Region: ParB; smart00470 309799006180 PAS fold; Region: PAS_4; pfam08448 309799006181 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 309799006182 putative active site [active] 309799006183 heme pocket [chemical binding]; other site 309799006184 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 309799006185 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 309799006186 metal binding site [ion binding]; metal-binding site 309799006187 active site 309799006188 I-site; other site 309799006189 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 309799006190 Zn2+ binding site [ion binding]; other site 309799006191 Mg2+ binding site [ion binding]; other site 309799006192 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 309799006193 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 309799006194 motif II; other site 309799006195 isocitrate dehydrogenase; Validated; Region: PRK08299 309799006196 The substrate binding domain of a cellulose-binding protein from Thermotoga maritima contains the type 2 periplasmic binding fold; Region: PBP2_TmCBP_oligosaccharides_like; cd08509 309799006197 substrate binding site [chemical binding]; other site 309799006198 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 309799006199 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 309799006200 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 309799006201 dimer interface [polypeptide binding]; other site 309799006202 conserved gate region; other site 309799006203 putative PBP binding loops; other site 309799006204 ABC-ATPase subunit interface; other site 309799006205 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 309799006206 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 309799006207 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 309799006208 dimer interface [polypeptide binding]; other site 309799006209 conserved gate region; other site 309799006210 putative PBP binding loops; other site 309799006211 ABC-ATPase subunit interface; other site 309799006212 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 309799006213 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 309799006214 Walker A/P-loop; other site 309799006215 ATP binding site [chemical binding]; other site 309799006216 Q-loop/lid; other site 309799006217 ABC transporter signature motif; other site 309799006218 Walker B; other site 309799006219 D-loop; other site 309799006220 H-loop/switch region; other site 309799006221 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 309799006222 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 309799006223 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 309799006224 Walker A/P-loop; other site 309799006225 ATP binding site [chemical binding]; other site 309799006226 Q-loop/lid; other site 309799006227 ABC transporter signature motif; other site 309799006228 Walker B; other site 309799006229 D-loop; other site 309799006230 H-loop/switch region; other site 309799006231 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 309799006232 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 309799006233 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 309799006234 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 309799006235 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 309799006236 Uncharacterized conserved protein [Function unknown]; Region: COG2006 309799006237 Domain of unknown function (DUF362); Region: DUF362; pfam04015 309799006238 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 309799006239 Glycosyl hydrolase family 20 (GH20) catalytic domain of N-acetyl-beta-D-glucosaminidase (GcnA, also known as BhsA) and related proteins. GcnA is an exoglucosidase which cleaves N-acetyl-beta-D-galactosamine (NAG) and N-acetyl-beta-D-galactosamine...; Region: GH20_GcnA-like; cd06565 309799006240 putative active site [active] 309799006241 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 309799006242 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 309799006243 active site 309799006244 dimer interface [polypeptide binding]; other site 309799006245 hypothetical protein; Provisional; Region: PRK02947 309799006246 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 309799006247 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 309799006248 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 309799006249 substrate binding pocket [chemical binding]; other site 309799006250 membrane-bound complex binding site; other site 309799006251 hinge residues; other site 309799006252 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 309799006253 GAF domain; Region: GAF; pfam01590 309799006254 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 309799006255 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 309799006256 Zn2+ binding site [ion binding]; other site 309799006257 Mg2+ binding site [ion binding]; other site 309799006258 Predicted GTPase [General function prediction only]; Region: COG2403 309799006259 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 309799006260 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase-like 1; Region: PLPDE_III_AR_like_1; cd06815 309799006261 Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457 309799006262 active site 309799006263 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 309799006264 dimer interface [polypeptide binding]; other site 309799006265 substrate binding site [chemical binding]; other site 309799006266 catalytic residue [active] 309799006267 MoxR-like ATPases [General function prediction only]; Region: COG0714 309799006268 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 309799006269 Walker A motif; other site 309799006270 ATP binding site [chemical binding]; other site 309799006271 Walker B motif; other site 309799006272 arginine finger; other site 309799006273 Protein of unknown function DUF58; Region: DUF58; pfam01882 309799006274 von Willebrand factor type A domain; Region: VWA_2; pfam13519 309799006275 metal ion-dependent adhesion site (MIDAS); other site 309799006276 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 309799006277 metal ion-dependent adhesion site (MIDAS); other site 309799006278 Protein of unknown function (DUF1355); Region: DUF1355; cl17712 309799006279 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 309799006280 metal ion-dependent adhesion site (MIDAS); other site 309799006281 Glycosyl hydrolases family 11; Region: Glyco_hydro_11; pfam00457 309799006282 Carbohydrate Binding Module families 36 (CBM36) and 6 (CBM6); appended mainly to glycoside hydrolase family 11 (GH11) domains; xylan binding; Region: CBM6_36_xylanase-like; cd04078 309799006283 Ca binding site [ion binding]; other site 309799006284 Ca binding site (active) [ion binding]; other site 309799006285 ligand binding site [chemical binding]; other site 309799006286 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 309799006287 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 309799006288 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 309799006289 Walker A/P-loop; other site 309799006290 ATP binding site [chemical binding]; other site 309799006291 Q-loop/lid; other site 309799006292 ABC transporter signature motif; other site 309799006293 Walker B; other site 309799006294 D-loop; other site 309799006295 H-loop/switch region; other site 309799006296 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 309799006297 homodimer interaction site [polypeptide binding]; other site 309799006298 cofactor binding site; other site 309799006299 Formylmethanofuran dehydrogenase subunit E [Energy production and conversion]; Region: COG2191 309799006300 FmdE, Molybdenum formylmethanofuran dehydrogenase operon; Region: FmdE; pfam02663 309799006301 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; pfam01258 309799006302 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 309799006303 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 309799006304 active site 309799006305 catalytic tetrad [active] 309799006306 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 309799006307 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 309799006308 Walker A/P-loop; other site 309799006309 ATP binding site [chemical binding]; other site 309799006310 Q-loop/lid; other site 309799006311 ABC transporter signature motif; other site 309799006312 Walker B; other site 309799006313 D-loop; other site 309799006314 H-loop/switch region; other site 309799006315 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 309799006316 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 309799006317 ABC-ATPase subunit interface; other site 309799006318 dimer interface [polypeptide binding]; other site 309799006319 putative PBP binding regions; other site 309799006320 Metal binding protein HemV-2. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: HemV-2; cd01147 309799006321 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 309799006322 putative metal binding site [ion binding]; other site 309799006323 Response regulator receiver domain; Region: Response_reg; pfam00072 309799006324 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 309799006325 active site 309799006326 phosphorylation site [posttranslational modification] 309799006327 intermolecular recognition site; other site 309799006328 dimerization interface [polypeptide binding]; other site 309799006329 PAS fold; Region: PAS; pfam00989 309799006330 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 309799006331 PAS fold; Region: PAS; pfam00989 309799006332 PAS domain; Region: PAS; smart00091 309799006333 putative active site [active] 309799006334 heme pocket [chemical binding]; other site 309799006335 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 309799006336 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 309799006337 Zn2+ binding site [ion binding]; other site 309799006338 Mg2+ binding site [ion binding]; other site 309799006339 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 309799006340 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 309799006341 active site 309799006342 HIGH motif; other site 309799006343 KMSKS motif; other site 309799006344 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 309799006345 tRNA binding surface [nucleotide binding]; other site 309799006346 anticodon binding site; other site 309799006347 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 309799006348 putative tRNA-binding site [nucleotide binding]; other site 309799006349 dimer interface [polypeptide binding]; other site 309799006350 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 309799006351 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 309799006352 Walker A motif; other site 309799006353 ATP binding site [chemical binding]; other site 309799006354 Walker B motif; other site 309799006355 arginine finger; other site 309799006356 hypothetical protein; Validated; Region: PRK00153 309799006357 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 309799006358 recombination protein RecR; Reviewed; Region: recR; PRK00076 309799006359 helix-hairpin-helix signature motif; other site 309799006360 RecR protein; Region: RecR; pfam02132 309799006361 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 309799006362 putative active site [active] 309799006363 putative metal-binding site [ion binding]; other site 309799006364 tetramer interface [polypeptide binding]; other site 309799006365 2-oxoacid:acceptor oxidoreductase, gamma subunit, pyruvate/2-ketoisovalerate family; Region: PorC_KorC; TIGR02175 309799006366 pyruvate/ketoisovalerate ferredoxin oxidoreductase subunit gamma; Provisional; Region: PRK14029 309799006367 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, delta subunit [Energy production and conversion]; Region: COG1144 309799006368 4Fe-4S binding domain; Region: Fer4; pfam00037 309799006369 pyruvate flavodoxin oxidoreductase subunit alpha; Reviewed; Region: porA; PRK09622 309799006370 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 309799006371 dimer interface [polypeptide binding]; other site 309799006372 PYR/PP interface [polypeptide binding]; other site 309799006373 TPP binding site [chemical binding]; other site 309799006374 substrate binding site [chemical binding]; other site 309799006375 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 309799006376 pyruvate ferredoxin oxidoreductase subunit beta; Provisional; Region: PRK11865 309799006377 Thiamine pyrophosphate (TPP family), PFOR porB-like subfamily, TPP-binding module; composed of proteins similar to the beta subunit (porB) of the Helicobacter pylori four-subunit pyruvate ferredoxin oxidoreductase (PFOR), which are also found in archaea...; Region: TPP_PFOR_porB_like; cd03376 309799006378 TPP-binding site [chemical binding]; other site 309799006379 putative dimer interface [polypeptide binding]; other site 309799006380 Endonuclease IV [DNA replication, recombination, and repair]; Region: Nfo; COG0648 309799006381 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 309799006382 AP (apurinic/apyrimidinic) site pocket; other site 309799006383 DNA interaction; other site 309799006384 Metal-binding active site; metal-binding site 309799006385 Acetyl esterase (deacetylase) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3458 309799006386 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 309799006387 TrkA-N domain; Region: TrkA_N; pfam02254 309799006388 TrkA-C domain; Region: TrkA_C; pfam02080 309799006389 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 309799006390 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 309799006391 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 309799006392 conserved cys residue [active]