-- dump date 20140619_065619 -- class Genbank::misc_feature -- table misc_feature_note -- id note 515635000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 515635000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 515635000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 515635000004 Walker A motif; other site 515635000005 ATP binding site [chemical binding]; other site 515635000006 Walker B motif; other site 515635000007 arginine finger; other site 515635000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 515635000009 DnaA box-binding interface [nucleotide binding]; other site 515635000010 High frequency of lysogenization C (HflC) family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_HflC; cd03405 515635000011 HflC protein; Region: hflC; TIGR01932 515635000012 High frequency of lysogenization K (HflK) family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_HflK; cd03404 515635000013 HflK protein; Region: hflK; TIGR01933 515635000014 Transcription factor zinc-finger; Region: zf-TFIIB; pfam13453 515635000015 Domain of unknown function (DUF4384); Region: DUF4384; pfam14326 515635000016 PEGA domain; Region: PEGA; pfam08308 515635000017 PEGA domain; Region: PEGA; pfam08308 515635000018 PEGA domain; Region: PEGA; pfam08308 515635000019 PEGA domain; Region: PEGA; pfam08308 515635000020 PEGA domain; Region: PEGA; pfam08308 515635000021 PAS fold; Region: PAS_4; pfam08448 515635000022 GAF domain; Region: GAF_3; pfam13492 515635000023 PAS domain S-box; Region: sensory_box; TIGR00229 515635000024 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 515635000025 metal binding site [ion binding]; metal-binding site 515635000026 active site 515635000027 I-site; other site 515635000028 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: PhosphMutase; cl17294 515635000029 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 515635000030 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 515635000031 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 515635000032 Walker A/P-loop; other site 515635000033 ATP binding site [chemical binding]; other site 515635000034 Q-loop/lid; other site 515635000035 ABC transporter signature motif; other site 515635000036 Walker B; other site 515635000037 D-loop; other site 515635000038 H-loop/switch region; other site 515635000039 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 515635000040 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 515635000041 Ferritin-like domain; Region: Ferritin; pfam00210 515635000042 dinuclear metal binding motif [ion binding]; other site 515635000043 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 515635000044 catalytic triad [active] 515635000045 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 515635000046 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 515635000047 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 515635000048 reverse gyrase; Reviewed; Region: PRK09401 515635000049 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 515635000050 ATP binding site [chemical binding]; other site 515635000051 putative Mg++ binding site [ion binding]; other site 515635000052 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 515635000053 nucleotide binding region [chemical binding]; other site 515635000054 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 515635000055 active site 515635000056 metal binding site [ion binding]; metal-binding site 515635000057 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 515635000058 domain I; other site 515635000059 DNA binding groove [nucleotide binding] 515635000060 phosphate binding site [ion binding]; other site 515635000061 domain II; other site 515635000062 domain III; other site 515635000063 nucleotide binding site [chemical binding]; other site 515635000064 catalytic site [active] 515635000065 domain IV; other site 515635000066 recombination protein F; Reviewed; Region: recF; PRK00064 515635000067 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 515635000068 Walker A/P-loop; other site 515635000069 ATP binding site [chemical binding]; other site 515635000070 Q-loop/lid; other site 515635000071 ABC transporter signature motif; other site 515635000072 Walker B; other site 515635000073 D-loop; other site 515635000074 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 515635000075 dimer interface [polypeptide binding]; other site 515635000076 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 515635000077 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 515635000078 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 515635000079 nucleotide binding site [chemical binding]; other site 515635000080 NEF interaction site [polypeptide binding]; other site 515635000081 SBD interface [polypeptide binding]; other site 515635000082 chaperone protein DnaJ; Region: DnaJ_bact; TIGR02349 515635000083 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 515635000084 HSP70 interaction site [polypeptide binding]; other site 515635000085 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 515635000086 substrate binding site [polypeptide binding]; other site 515635000087 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 515635000088 Zn binding sites [ion binding]; other site 515635000089 dimer interface [polypeptide binding]; other site 515635000090 LexA repressor; Validated; Region: PRK00215 515635000091 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 515635000092 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 515635000093 Catalytic site [active] 515635000094 Predicted dehydrogenase [General function prediction only]; Region: COG0579 515635000095 hydroxyglutarate oxidase; Provisional; Region: PRK11728; cl19156 515635000096 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 515635000097 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 515635000098 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 515635000099 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 515635000100 Uncharacterized protein with conserved CXXC pairs [Function unknown]; Region: COG3862 515635000101 Glutamate synthase domain 1 [Amino acid transport and metabolism]; Region: GltB; COG0067 515635000102 Glutamine amidotransferases class-II (Gn-AT)_GlxB-type. GlxB is a glutamine amidotransferase-like protein of unknown function found in bacteria and archaea. GlxB has a structural fold similar to that of other class II glutamine amidotransferases...; Region: GlxB; cd01907 515635000103 putative active site [active] 515635000104 Archaeal-type gltB domain. This domain shares sequence similarity with a region of unknown function found in the large subunit of glutamate synthase, which is encoded by gltB and found in most bacteria and eukaryotes. It is predicted to be homologous to...; Region: arch_gltB; cd00981 515635000105 putative subunit interface; other site 515635000106 cysteine synthase; Region: PLN02565 515635000107 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 515635000108 dimer interface [polypeptide binding]; other site 515635000109 pyridoxal 5'-phosphate binding site [chemical binding]; other site 515635000110 catalytic residue [active] 515635000111 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 515635000112 Uridine monophosphate kinase_like (UMPK_like) is a family of proteins highly similar to the uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK); Region: UMPK_like; cd02028 515635000113 active site 515635000114 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 515635000115 oligomerisation interface [polypeptide binding]; other site 515635000116 mobile loop; other site 515635000117 roof hairpin; other site 515635000118 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 515635000119 catalytic residues [active] 515635000120 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 515635000121 intersubunit interface [polypeptide binding]; other site 515635000122 active site 515635000123 zinc binding site [ion binding]; other site 515635000124 Na+ binding site [ion binding]; other site 515635000125 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 515635000126 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 515635000127 AP (apurinic/apyrimidinic) site pocket; other site 515635000128 DNA interaction; other site 515635000129 Metal-binding active site; metal-binding site 515635000130 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 515635000131 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 515635000132 homodimer interface [polypeptide binding]; other site 515635000133 Walker A motif; other site 515635000134 ATP binding site [chemical binding]; other site 515635000135 hydroxycobalamin binding site [chemical binding]; other site 515635000136 Walker B motif; other site 515635000137 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 515635000138 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 515635000139 ligand binding site [chemical binding]; other site 515635000140 NAD binding site [chemical binding]; other site 515635000141 dimerization interface [polypeptide binding]; other site 515635000142 catalytic site [active] 515635000143 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 515635000144 putative L-serine binding site [chemical binding]; other site 515635000145 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 515635000146 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 515635000147 catalytic residue [active] 515635000148 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 515635000149 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 515635000150 trimer interface [polypeptide binding]; other site 515635000151 putative metal binding site [ion binding]; other site 515635000152 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 515635000153 rod shape-determining protein MreC; Region: MreC; cl19252 515635000154 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 515635000155 Peptidase family M23; Region: Peptidase_M23; pfam01551 515635000156 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 515635000157 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 515635000158 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 515635000159 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 515635000160 Protein of unknown function DUF58; Region: DUF58; pfam01882 515635000161 MoxR-like ATPases [General function prediction only]; Region: COG0714 515635000162 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 515635000163 Walker A motif; other site 515635000164 ATP binding site [chemical binding]; other site 515635000165 Walker B motif; other site 515635000166 arginine finger; other site 515635000167 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 515635000168 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 515635000169 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 515635000170 DNA binding residues [nucleotide binding] 515635000171 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 515635000172 trimer interface [polypeptide binding]; other site 515635000173 active site 515635000174 Domain of unknown function (DUF4380); Region: DUF4380; pfam14315 515635000175 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 515635000176 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 515635000177 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 515635000178 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 515635000179 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 515635000180 active site 515635000181 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 515635000182 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 515635000183 Substrate binding site; other site 515635000184 Cupin domain; Region: Cupin_2; cl17218 515635000185 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 515635000186 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 515635000187 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 515635000188 PhoU domain; Region: PhoU; pfam01895 515635000189 PhoU domain; Region: PhoU; pfam01895 515635000190 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 515635000191 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 515635000192 NAD(P) binding site [chemical binding]; other site 515635000193 active site 515635000194 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 515635000195 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 515635000196 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 515635000197 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 515635000198 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 515635000199 Walker A/P-loop; other site 515635000200 ATP binding site [chemical binding]; other site 515635000201 Q-loop/lid; other site 515635000202 ABC transporter signature motif; other site 515635000203 Walker B; other site 515635000204 D-loop; other site 515635000205 H-loop/switch region; other site 515635000206 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 515635000207 ABC-2 type transporter; Region: ABC2_membrane; cl17235 515635000208 Predicted transcriptional regulator [Transcription]; Region: COG2378 515635000209 HTH domain; Region: HTH_11; cl17392 515635000210 WYL domain; Region: WYL; pfam13280 515635000211 competence damage-inducible protein A; Provisional; Region: PRK00549 515635000212 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 515635000213 putative MPT binding site; other site 515635000214 Competence-damaged protein; Region: CinA; pfam02464 515635000215 GAF domain; Region: GAF_2; pfam13185 515635000216 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 515635000217 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 515635000218 Zn2+ binding site [ion binding]; other site 515635000219 Mg2+ binding site [ion binding]; other site 515635000220 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 515635000221 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 515635000222 metal binding site [ion binding]; metal-binding site 515635000223 dimer interface [polypeptide binding]; other site 515635000224 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 515635000225 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 515635000226 active site 515635000227 substrate binding site [chemical binding]; other site 515635000228 metal binding site [ion binding]; metal-binding site 515635000229 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 515635000230 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 515635000231 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 515635000232 DNA binding residues [nucleotide binding] 515635000233 transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283 515635000234 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 515635000235 active site 515635000236 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 515635000237 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; pfam02660 515635000238 Dolichol kinase [Lipid metabolism]; Region: SEC59; COG0170 515635000239 Homocysteine S-methyltransferase; Region: S-methyl_trans; cl14105 515635000240 hydrogenase nickel incorporation protein; Provisional; Region: hypA; PRK03824 515635000241 MinD superfamily P-loop ATPase containing an inserted ferredoxin domain [Energy production and conversion]; Region: COG1149 515635000242 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 515635000243 bidirectional hydrogenase complex protein HoxU; Validated; Region: PRK07569 515635000244 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 515635000245 catalytic loop [active] 515635000246 iron binding site [ion binding]; other site 515635000247 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 515635000248 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 515635000249 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 515635000250 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 515635000251 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cd00368 515635000252 molybdopterin cofactor binding site; other site 515635000253 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 515635000254 Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259 515635000255 Hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). These enzymes belong to the peptidase family M52. Maturation of [FeNi] hydrogenases includes formation of the nickel metallocenter, proteolytic processing...; Region: H2MP; cl00477 515635000256 nickel binding site [ion binding]; other site 515635000257 Acylphosphatase; Region: Acylphosphatase; pfam00708 515635000258 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 515635000259 HypF finger; Region: zf-HYPF; pfam07503 515635000260 HypF finger; Region: zf-HYPF; pfam07503 515635000261 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 515635000262 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 515635000263 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 515635000264 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 515635000265 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 515635000266 The substrate binding domain of a cellulose-binding protein from Thermotoga maritima contains the type 2 periplasmic binding fold; Region: PBP2_TmCBP_oligosaccharides_like; cd08509 515635000267 substrate binding site [chemical binding]; other site 515635000268 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 515635000269 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 515635000270 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 515635000271 dimer interface [polypeptide binding]; other site 515635000272 conserved gate region; other site 515635000273 putative PBP binding loops; other site 515635000274 ABC-ATPase subunit interface; other site 515635000275 nickel transporter permease NikC; Provisional; Region: nikC; PRK10417 515635000276 Ligand Binding Domain of Ephrin Receptors; Region: EphR_LBD; cl02704 515635000277 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 515635000278 dimer interface [polypeptide binding]; other site 515635000279 conserved gate region; other site 515635000280 putative PBP binding loops; other site 515635000281 ABC-ATPase subunit interface; other site 515635000282 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 515635000283 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 515635000284 Walker A/P-loop; other site 515635000285 ATP binding site [chemical binding]; other site 515635000286 Q-loop/lid; other site 515635000287 ABC transporter signature motif; other site 515635000288 Walker B; other site 515635000289 D-loop; other site 515635000290 H-loop/switch region; other site 515635000291 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 515635000292 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 515635000293 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 515635000294 Walker A/P-loop; other site 515635000295 ATP binding site [chemical binding]; other site 515635000296 Q-loop/lid; other site 515635000297 ABC transporter signature motif; other site 515635000298 Walker B; other site 515635000299 D-loop; other site 515635000300 H-loop/switch region; other site 515635000301 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 515635000302 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cl00226 515635000303 HupF/HypC family; Region: HupF_HypC; pfam01455 515635000304 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 515635000305 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 515635000306 dimerization interface [polypeptide binding]; other site 515635000307 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 515635000308 ATP binding site [chemical binding]; other site 515635000309 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 515635000310 putative substrate translocation pore; other site 515635000311 Major Facilitator Superfamily; Region: MFS_1; pfam07690 515635000312 Domain of unknown function (DUF362); Region: DUF362; pfam04015 515635000313 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 515635000314 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 515635000315 ABC-2 type transporter; Region: ABC2_membrane; cl17235 515635000316 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 515635000317 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 515635000318 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 515635000319 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 515635000320 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 515635000321 Walker A/P-loop; other site 515635000322 ATP binding site [chemical binding]; other site 515635000323 Q-loop/lid; other site 515635000324 ABC transporter signature motif; other site 515635000325 Walker B; other site 515635000326 D-loop; other site 515635000327 H-loop/switch region; other site 515635000328 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 515635000329 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 515635000330 RNA binding surface [nucleotide binding]; other site 515635000331 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 515635000332 active site 515635000333 uracil binding [chemical binding]; other site 515635000334 Glycoside hydrolase family 44; Region: Glyco_hydro_44; pfam12891 515635000335 Uncharacterized protein family (UPF0175); Region: UPF0175; pfam03683 515635000336 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2405 515635000337 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cl00399 515635000338 Domain of unknown function (DUF3368); Region: DUF3368; pfam11848 515635000339 HEPN domain; Region: HEPN; cl00824 515635000340 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 515635000341 active site 515635000342 NTP binding site [chemical binding]; other site 515635000343 metal binding triad [ion binding]; metal-binding site 515635000344 antibiotic binding site [chemical binding]; other site 515635000345 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 515635000346 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 515635000347 Bacitracin resistance protein BacA; Region: BacA; pfam02673 515635000348 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 515635000349 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 515635000350 trmE is a tRNA modification GTPase; Region: trmE; cd04164 515635000351 G1 box; other site 515635000352 GTP/Mg2+ binding site [chemical binding]; other site 515635000353 Switch I region; other site 515635000354 G2 box; other site 515635000355 Switch II region; other site 515635000356 G3 box; other site 515635000357 G4 box; other site 515635000358 G5 box; other site 515635000359 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 515635000360 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 515635000361 Jag N-terminus; Region: Jag_N; pfam14804 515635000362 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 515635000363 G-X-X-G motif; other site 515635000364 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 515635000365 RxxxH motif; other site 515635000366 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 515635000367 hypothetical protein; Validated; Region: PRK00041 515635000368 Ribonuclease P; Region: Ribonuclease_P; cl00457 515635000369 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 515635000370 nicotinate phosphoribosyltransferase; Reviewed; Region: PRK08662 515635000371 Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an important role in NAD production by either allowing quinolinic acid (QA) , quinolinate phosphoribosyl transferase (QAPRTase), or nicotinic acid (NA), nicotinate...; Region: PRTase_typeII; cl17275 515635000372 active site 515635000373 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 515635000374 catalytic triad [active] 515635000375 conserved cis-peptide bond; other site 515635000376 Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894 515635000377 Uncharacterized conserved protein [Function unknown]; Region: RtcB; COG1690 515635000378 tRNA-splicing ligase RtcB; Region: RtcB; pfam01139 515635000379 Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; cl00852 515635000380 F0F1-type ATP synthase, epsilon subunit (mitochondrial delta subunit) [Energy production and conversion]; Region: AtpC; COG0355 515635000381 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 515635000382 gamma subunit interface [polypeptide binding]; other site 515635000383 epsilon subunit interface [polypeptide binding]; other site 515635000384 LBP interface [polypeptide binding]; other site 515635000385 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 515635000386 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 515635000387 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 515635000388 alpha subunit interaction interface [polypeptide binding]; other site 515635000389 Walker A motif; other site 515635000390 ATP binding site [chemical binding]; other site 515635000391 Walker B motif; other site 515635000392 inhibitor binding site; inhibition site 515635000393 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 515635000394 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 515635000395 core domain interface [polypeptide binding]; other site 515635000396 delta subunit interface [polypeptide binding]; other site 515635000397 epsilon subunit interface [polypeptide binding]; other site 515635000398 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 515635000399 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 515635000400 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 515635000401 Walker A motif; other site 515635000402 ATP binding site [chemical binding]; other site 515635000403 Walker B motif; other site 515635000404 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 515635000405 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 515635000406 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 515635000407 ATP synthase delta (OSCP) subunit; Region: OSCP; cl17210 515635000408 ATP synthase subunit C; Region: ATP-synt_C; cl00466 515635000409 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 515635000410 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527 515635000411 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 515635000412 Yqey-like protein; Region: YqeY; cl17540 515635000413 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 515635000414 active site 515635000415 Zn binding site [ion binding]; other site 515635000416 Uncharacterized conserved protein [Function unknown]; Region: COG1739 515635000417 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 515635000418 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 515635000419 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 515635000420 protein binding site [polypeptide binding]; other site 515635000421 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 515635000422 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 515635000423 Protein of unknown function (DUF3089); Region: DUF3089; pfam11288 515635000424 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 515635000425 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 515635000426 Rubredoxin [Energy production and conversion]; Region: COG1773 515635000427 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 515635000428 iron binding site [ion binding]; other site 515635000429 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 515635000430 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 515635000431 Lipopolysaccharide-assembly, LptC-related; Region: LptC; cl01200 515635000432 OstA-like protein; Region: OstA; cl00844 515635000433 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 515635000434 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 515635000435 putative active site [active] 515635000436 catalytic triad [active] 515635000437 putative dimer interface [polypeptide binding]; other site 515635000438 HAMP domain; Region: HAMP; pfam00672 515635000439 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 515635000440 dimer interface [polypeptide binding]; other site 515635000441 phosphorylation site [posttranslational modification] 515635000442 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 515635000443 ATP binding site [chemical binding]; other site 515635000444 Mg2+ binding site [ion binding]; other site 515635000445 G-X-G motif; other site 515635000446 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 515635000447 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 515635000448 active site 515635000449 phosphorylation site [posttranslational modification] 515635000450 intermolecular recognition site; other site 515635000451 dimerization interface [polypeptide binding]; other site 515635000452 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 515635000453 DNA binding site [nucleotide binding] 515635000454 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 515635000455 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 515635000456 active site 515635000457 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 515635000458 O-Antigen ligase; Region: Wzy_C; pfam04932 515635000459 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 515635000460 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 515635000461 NAD binding site [chemical binding]; other site 515635000462 sugar binding site [chemical binding]; other site 515635000463 divalent metal binding site [ion binding]; other site 515635000464 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 515635000465 dimer interface [polypeptide binding]; other site 515635000466 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 515635000467 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 515635000468 Walker A/P-loop; other site 515635000469 ATP binding site [chemical binding]; other site 515635000470 Q-loop/lid; other site 515635000471 ABC transporter signature motif; other site 515635000472 Walker B; other site 515635000473 D-loop; other site 515635000474 H-loop/switch region; other site 515635000475 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 515635000476 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 515635000477 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 515635000478 Walker A/P-loop; other site 515635000479 ATP binding site [chemical binding]; other site 515635000480 Q-loop/lid; other site 515635000481 ABC transporter signature motif; other site 515635000482 Walker B; other site 515635000483 D-loop; other site 515635000484 H-loop/switch region; other site 515635000485 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 515635000486 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 515635000487 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 515635000488 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 515635000489 dimer interface [polypeptide binding]; other site 515635000490 conserved gate region; other site 515635000491 putative PBP binding loops; other site 515635000492 ABC-ATPase subunit interface; other site 515635000493 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 515635000494 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 515635000495 dimer interface [polypeptide binding]; other site 515635000496 conserved gate region; other site 515635000497 putative PBP binding loops; other site 515635000498 ABC-ATPase subunit interface; other site 515635000499 The substrate binding domain of a cellulose-binding protein from Thermotoga maritima contains the type 2 periplasmic binding fold; Region: PBP2_TmCBP_oligosaccharides_like; cd08509 515635000500 substrate binding site [chemical binding]; other site 515635000501 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 515635000502 Transcriptional regulators [Transcription]; Region: PurR; COG1609 515635000503 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 515635000504 DNA binding site [nucleotide binding] 515635000505 domain linker motif; other site 515635000506 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 515635000507 dimerization interface [polypeptide binding]; other site 515635000508 ligand binding site [chemical binding]; other site 515635000509 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4370 515635000510 conserved hypothetical protein; Region: TIGR03492 515635000511 Domain of unknown function (DUF4272); Region: DUF4272; pfam14094 515635000512 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 515635000513 active site 515635000514 NAD binding site [chemical binding]; other site 515635000515 metal binding site [ion binding]; metal-binding site 515635000516 Cytidylate kinase-like family; Region: Cytidylate_kin2; pfam13189 515635000517 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 515635000518 active site 515635000519 Predicted transcriptional regulators [Transcription]; Region: COG1695 515635000520 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 515635000521 Glycosyl hydrolases family 31; Region: Glyco_hydro_31; pfam01055 515635000522 Alpha-glucosidase II (alpha-D-glucoside glucohydrolase) is a glycosyl hydrolase family 31 (GH31) enzyme, found in bacteria and plants, which has exo-alpha-1,4-glucosidase and oligo-1,6-glucosidase activities. Alpha-glucosidase II has been characterized...; Region: GH31_glucosidase_II_MalA; cd06604 515635000523 trimer interface [polypeptide binding]; other site 515635000524 active site 515635000525 homohexamer (dimer of homotrimer) interface [polypeptide binding]; other site 515635000526 catalytic site [active] 515635000527 Pectate lyase superfamily protein; Region: Pectate_lyase_3; cl19188 515635000528 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 515635000529 sugar binding site [chemical binding]; other site 515635000530 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 515635000531 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 515635000532 dimer interface [polypeptide binding]; other site 515635000533 conserved gate region; other site 515635000534 putative PBP binding loops; other site 515635000535 ABC-ATPase subunit interface; other site 515635000536 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 515635000537 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 515635000538 dimer interface [polypeptide binding]; other site 515635000539 conserved gate region; other site 515635000540 putative PBP binding loops; other site 515635000541 ABC-ATPase subunit interface; other site 515635000542 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 515635000543 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 515635000544 Transcriptional regulators [Transcription]; Region: PurR; COG1609 515635000545 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 515635000546 DNA binding site [nucleotide binding] 515635000547 domain linker motif; other site 515635000548 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 515635000549 dimerization interface [polypeptide binding]; other site 515635000550 ligand binding site [chemical binding]; other site 515635000551 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 515635000552 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 515635000553 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 515635000554 Peptidase family M48; Region: Peptidase_M48; pfam01435 515635000555 NAD synthetase; Provisional; Region: PRK13981 515635000556 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 515635000557 multimer interface [polypeptide binding]; other site 515635000558 active site 515635000559 catalytic triad [active] 515635000560 protein interface 1 [polypeptide binding]; other site 515635000561 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 515635000562 homodimer interface [polypeptide binding]; other site 515635000563 NAD binding pocket [chemical binding]; other site 515635000564 ATP binding pocket [chemical binding]; other site 515635000565 Mg binding site [ion binding]; other site 515635000566 active-site loop [active] 515635000567 transketolase; Reviewed; Region: PRK05899 515635000568 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 515635000569 TPP-binding site [chemical binding]; other site 515635000570 dimer interface [polypeptide binding]; other site 515635000571 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 515635000572 PYR/PP interface [polypeptide binding]; other site 515635000573 dimer interface [polypeptide binding]; other site 515635000574 TPP binding site [chemical binding]; other site 515635000575 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 515635000576 histidinol-phosphatase; Provisional; Region: PRK07328 515635000577 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 515635000578 active site 515635000579 dimer interface [polypeptide binding]; other site 515635000580 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 515635000581 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 515635000582 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 515635000583 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 515635000584 putative dimer interface [polypeptide binding]; other site 515635000585 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 515635000586 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 515635000587 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 515635000588 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 515635000589 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 515635000590 Chromate transporter; Region: Chromate_transp; pfam02417 515635000591 Chromate transporter; Region: Chromate_transp; pfam02417 515635000592 Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_12; cd12177 515635000593 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 515635000594 putative ligand binding site [chemical binding]; other site 515635000595 putative NAD binding site [chemical binding]; other site 515635000596 catalytic site [active] 515635000597 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 515635000598 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 515635000599 N- and C-terminal domain interface [polypeptide binding]; other site 515635000600 active site 515635000601 catalytic site [active] 515635000602 metal binding site [ion binding]; metal-binding site 515635000603 carbohydrate binding site [chemical binding]; other site 515635000604 ATP binding site [chemical binding]; other site 515635000605 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 515635000606 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 515635000607 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 515635000608 D-mannonate oxidoreductase; Provisional; Region: PRK08277 515635000609 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 515635000610 NAD(P) binding site [chemical binding]; other site 515635000611 active site 515635000612 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 515635000613 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432 515635000614 active site 515635000615 PHP-associated; Region: PHP_C; pfam13263 515635000616 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 515635000617 Major Facilitator Superfamily; Region: MFS_1; pfam07690 515635000618 putative substrate translocation pore; other site 515635000619 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 515635000620 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 515635000621 active site 515635000622 catalytic site [active] 515635000623 N-glycosylase/DNA lyase; Provisional; Region: PRK01229 515635000624 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 515635000625 minor groove reading motif; other site 515635000626 helix-hairpin-helix signature motif; other site 515635000627 active site 515635000628 Sugar fermentation stimulation protein; Region: SfsA; cl00647 515635000629 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 515635000630 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 515635000631 Major Facilitator Superfamily; Region: MFS_1; pfam07690 515635000632 putative substrate translocation pore; other site 515635000633 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 515635000634 dinuclear metal binding motif [ion binding]; other site 515635000635 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 515635000636 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 515635000637 P-loop; other site 515635000638 Magnesium ion binding site [ion binding]; other site 515635000639 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 515635000640 ParB-like nuclease domain; Region: ParB; smart00470 515635000641 KorB domain; Region: KorB; pfam08535 515635000642 PAS fold; Region: PAS_4; pfam08448 515635000643 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 515635000644 putative active site [active] 515635000645 heme pocket [chemical binding]; other site 515635000646 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 515635000647 metal binding site [ion binding]; metal-binding site 515635000648 active site 515635000649 I-site; other site 515635000650 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 515635000651 Zn2+ binding site [ion binding]; other site 515635000652 Mg2+ binding site [ion binding]; other site 515635000653 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 515635000654 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 515635000655 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 515635000656 active site 515635000657 motif I; other site 515635000658 motif II; other site 515635000659 isocitrate dehydrogenase; Validated; Region: PRK08299 515635000660 The substrate binding domain of a cellulose-binding protein from Thermotoga maritima contains the type 2 periplasmic binding fold; Region: PBP2_TmCBP_oligosaccharides_like; cd08509 515635000661 substrate binding site [chemical binding]; other site 515635000662 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 515635000663 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 515635000664 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 515635000665 dimer interface [polypeptide binding]; other site 515635000666 conserved gate region; other site 515635000667 putative PBP binding loops; other site 515635000668 ABC-ATPase subunit interface; other site 515635000669 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 515635000670 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 515635000671 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 515635000672 dimer interface [polypeptide binding]; other site 515635000673 conserved gate region; other site 515635000674 putative PBP binding loops; other site 515635000675 ABC-ATPase subunit interface; other site 515635000676 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 515635000677 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 515635000678 Walker A/P-loop; other site 515635000679 ATP binding site [chemical binding]; other site 515635000680 Q-loop/lid; other site 515635000681 ABC transporter signature motif; other site 515635000682 Walker B; other site 515635000683 D-loop; other site 515635000684 H-loop/switch region; other site 515635000685 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 515635000686 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 515635000687 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 515635000688 Walker A/P-loop; other site 515635000689 ATP binding site [chemical binding]; other site 515635000690 Q-loop/lid; other site 515635000691 ABC transporter signature motif; other site 515635000692 Walker B; other site 515635000693 D-loop; other site 515635000694 H-loop/switch region; other site 515635000695 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 515635000696 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 515635000697 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 515635000698 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 515635000699 Domain of unknown function (DUF362); Region: DUF362; pfam04015 515635000700 Glycosyl hydrolase family 20 (GH20) catalytic domain of N-acetyl-beta-D-glucosaminidase (GcnA, also known as BhsA) and related proteins. GcnA is an exoglucosidase which cleaves N-acetyl-beta-D-galactosamine (NAG) and N-acetyl-beta-D-galactosamine...; Region: GH20_GcnA-like; cd06565 515635000701 putative active site [active] 515635000702 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 515635000703 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 515635000704 active site 515635000705 dimer interface [polypeptide binding]; other site 515635000706 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 515635000707 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 515635000708 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 515635000709 substrate binding pocket [chemical binding]; other site 515635000710 membrane-bound complex binding site; other site 515635000711 hinge residues; other site 515635000712 GAF domain; Region: GAF; pfam01590 515635000713 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 515635000714 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 515635000715 Zn2+ binding site [ion binding]; other site 515635000716 Mg2+ binding site [ion binding]; other site 515635000717 Predicted GTPase [General function prediction only]; Region: COG2403 515635000718 Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; cl19279 515635000719 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 515635000720 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase-like 1; Region: PLPDE_III_AR_like_1; cd06815 515635000721 Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457 515635000722 active site 515635000723 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 515635000724 dimer interface [polypeptide binding]; other site 515635000725 substrate binding site [chemical binding]; other site 515635000726 catalytic residue [active] 515635000727 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 515635000728 EamA-like transporter family; Region: EamA; cl17759 515635000729 acyl-CoA synthetase; Provisional; Region: PTZ00342 515635000730 MoxR-like ATPases [General function prediction only]; Region: COG0714 515635000731 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 515635000732 Walker A motif; other site 515635000733 ATP binding site [chemical binding]; other site 515635000734 Walker B motif; other site 515635000735 arginine finger; other site 515635000736 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 515635000737 Protein of unknown function DUF58; Region: DUF58; pfam01882 515635000738 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 515635000739 metal ion-dependent adhesion site (MIDAS); other site 515635000740 Aerotolerance regulator N-terminal; Region: BatA; pfam07584 515635000741 von Willebrand factor type A domain; Region: VWA_2; pfam13519 515635000742 metal ion-dependent adhesion site (MIDAS); other site 515635000743 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 515635000744 metal ion-dependent adhesion site (MIDAS); other site 515635000745 Protein of unknown function (DUF1355); Region: DUF1355; cl17712 515635000746 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 515635000747 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 515635000748 metal ion-dependent adhesion site (MIDAS); other site 515635000749 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 515635000750 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 515635000751 active site 515635000752 phosphorylation site [posttranslational modification] 515635000753 intermolecular recognition site; other site 515635000754 dimerization interface [polypeptide binding]; other site 515635000755 HEAT repeats; Region: HEAT_2; pfam13646 515635000756 Protein of unknown function (DUF793); Region: DUF793; pfam05633 515635000757 HEAT repeats; Region: HEAT_2; pfam13646 515635000758 PAS domain S-box; Region: sensory_box; TIGR00229 515635000759 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 515635000760 metal binding site [ion binding]; metal-binding site 515635000761 active site 515635000762 I-site; other site 515635000763 Predicted peptidase [General function prediction only]; Region: COG4099 515635000764 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 515635000765 Glycosyl hydrolases family 11; Region: Glyco_hydro_11; pfam00457 515635000766 Carbohydrate Binding Module families 36 (CBM36) and 6 (CBM6); appended mainly to glycoside hydrolase family 11 (GH11) domains; xylan binding; Region: CBM6_36_xylanase-like; cd04078 515635000767 Ca binding site [ion binding]; other site 515635000768 Ca binding site (active) [ion binding]; other site 515635000769 ligand binding site [chemical binding]; other site 515635000770 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 515635000771 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 515635000772 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 515635000773 Walker A/P-loop; other site 515635000774 ATP binding site [chemical binding]; other site 515635000775 Q-loop/lid; other site 515635000776 ABC transporter signature motif; other site 515635000777 Walker B; other site 515635000778 D-loop; other site 515635000779 H-loop/switch region; other site 515635000780 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 515635000781 homodimer interaction site [polypeptide binding]; other site 515635000782 cofactor binding site; other site 515635000783 Formylmethanofuran dehydrogenase subunit E [Energy production and conversion]; Region: COG2191 515635000784 FmdE, Molybdenum formylmethanofuran dehydrogenase operon; Region: FmdE; pfam02663 515635000785 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; pfam01258 515635000786 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 515635000787 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 515635000788 Walker A/P-loop; other site 515635000789 ATP binding site [chemical binding]; other site 515635000790 Q-loop/lid; other site 515635000791 ABC transporter signature motif; other site 515635000792 Walker B; other site 515635000793 D-loop; other site 515635000794 H-loop/switch region; other site 515635000795 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 515635000796 ABC-ATPase subunit interface; other site 515635000797 dimer interface [polypeptide binding]; other site 515635000798 putative PBP binding regions; other site 515635000799 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 515635000800 Metal binding protein HemV-2. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: HemV-2; cd01147 515635000801 putative metal binding site [ion binding]; other site 515635000802 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 515635000803 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 515635000804 active site 515635000805 phosphorylation site [posttranslational modification] 515635000806 intermolecular recognition site; other site 515635000807 dimerization interface [polypeptide binding]; other site 515635000808 PAS fold; Region: PAS; pfam00989 515635000809 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 515635000810 putative active site [active] 515635000811 heme pocket [chemical binding]; other site 515635000812 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 515635000813 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 515635000814 Zn2+ binding site [ion binding]; other site 515635000815 Mg2+ binding site [ion binding]; other site 515635000816 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 515635000817 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 515635000818 active site 515635000819 HIGH motif; other site 515635000820 KMSKS motif; other site 515635000821 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 515635000822 tRNA binding surface [nucleotide binding]; other site 515635000823 anticodon binding site; other site 515635000824 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 515635000825 dimer interface [polypeptide binding]; other site 515635000826 putative tRNA-binding site [nucleotide binding]; other site 515635000827 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 515635000828 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 515635000829 Walker A motif; other site 515635000830 ATP binding site [chemical binding]; other site 515635000831 Walker B motif; other site 515635000832 arginine finger; other site 515635000833 hypothetical protein; Validated; Region: PRK00153 515635000834 Helix-hairpin-helix motif; Region: HHH; pfam00633 515635000835 recombination protein RecR; Reviewed; Region: recR; PRK00076 515635000836 RecR protein; Region: RecR; pfam02132 515635000837 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 515635000838 putative active site [active] 515635000839 putative metal-binding site [ion binding]; other site 515635000840 tetramer interface [polypeptide binding]; other site 515635000841 2-oxoacid:acceptor oxidoreductase, gamma subunit, pyruvate/2-ketoisovalerate family; Region: PorC_KorC; TIGR02175 515635000842 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, delta subunit [Energy production and conversion]; Region: COG1144 515635000843 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 515635000844 4Fe-4S binding domain; Region: Fer4; pfam00037 515635000845 pyruvate flavodoxin oxidoreductase subunit alpha; Reviewed; Region: porA; PRK09622 515635000846 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 515635000847 dimer interface [polypeptide binding]; other site 515635000848 PYR/PP interface [polypeptide binding]; other site 515635000849 TPP binding site [chemical binding]; other site 515635000850 substrate binding site [chemical binding]; other site 515635000851 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 515635000852 pyruvate ferredoxin oxidoreductase subunit beta; Provisional; Region: PRK11865 515635000853 Thiamine pyrophosphate (TPP family), PFOR porB-like subfamily, TPP-binding module; composed of proteins similar to the beta subunit (porB) of the Helicobacter pylori four-subunit pyruvate ferredoxin oxidoreductase (PFOR), which are also found in archaea...; Region: TPP_PFOR_porB_like; cd03376 515635000854 TPP-binding site [chemical binding]; other site 515635000855 putative dimer interface [polypeptide binding]; other site 515635000856 Endonuclease IV [DNA replication, recombination, and repair]; Region: Nfo; COG0648 515635000857 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 515635000858 Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448 515635000859 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 515635000860 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 515635000861 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 515635000862 TrkA-N domain; Region: TrkA_N; pfam02254 515635000863 TrkA-C domain; Region: TrkA_C; pfam02080 515635000864 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 515635000865 Cation transport protein; Region: TrkH; cl17365 515635000866 phosphoribosylaminoimidazole carboxylase, PurE protein; Region: purE; TIGR01162 515635000867 phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional; Region: PRK13959 515635000868 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt; cl00231 515635000869 active site 515635000870 ATP binding site [chemical binding]; other site 515635000871 substrate binding site [chemical binding]; other site 515635000872 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 515635000873 MgtC family; Region: MgtC; pfam02308 515635000874 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 515635000875 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 515635000876 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 515635000877 The substrate binding domain of a cellulose-binding protein from Thermotoga maritima contains the type 2 periplasmic binding fold; Region: PBP2_TmCBP_oligosaccharides_like; cd08509 515635000878 substrate binding site [chemical binding]; other site 515635000879 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 515635000880 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 515635000881 S-adenosylmethionine binding site [chemical binding]; other site 515635000882 O-methyltransferase; Region: Methyltransf_2; pfam00891 515635000883 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 515635000884 TPR motif; other site 515635000885 binding surface 515635000886 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 515635000887 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 515635000888 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 515635000889 putative metal binding site [ion binding]; other site 515635000890 Glycosyl hydrolase family 26; Region: Glyco_hydro_26; pfam02156 515635000891 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 515635000892 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 515635000893 uncharacterized radical SAM protein YgiQ; Region: SAM_YgiQ; TIGR03904 515635000894 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 515635000895 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 515635000896 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 515635000897 GAF domain; Region: GAF_2; pfam13185 515635000898 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 515635000899 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 515635000900 putative active site [active] 515635000901 heme pocket [chemical binding]; other site 515635000902 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 515635000903 ATP binding site [chemical binding]; other site 515635000904 Mg2+ binding site [ion binding]; other site 515635000905 G-X-G motif; other site 515635000906 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 515635000907 active site 515635000908 phosphorylation site [posttranslational modification] 515635000909 intermolecular recognition site; other site 515635000910 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 515635000911 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 515635000912 dimer interface [polypeptide binding]; other site 515635000913 phosphorylation site [posttranslational modification] 515635000914 Putative catalytic NodB homology domain of a hypothetical protein Ecf1 from Escherichia coli and similar proteins; Region: CE4_Ecf1_like_5s; cd10969 515635000915 putative active site [active] 515635000916 putative metal binding site [ion binding]; other site 515635000917 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 515635000918 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 515635000919 NAD(P) binding site [chemical binding]; other site 515635000920 active site 515635000921 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 515635000922 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 515635000923 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 515635000924 Uncharacterized conserved protein [Function unknown]; Region: COG0432 515635000925 Membrane transport protein; Region: Mem_trans; cl09117 515635000926 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 515635000927 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_4; cd08500 515635000928 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 515635000929 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 515635000930 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 515635000931 Walker A/P-loop; other site 515635000932 ATP binding site [chemical binding]; other site 515635000933 Q-loop/lid; other site 515635000934 ABC transporter signature motif; other site 515635000935 Walker B; other site 515635000936 D-loop; other site 515635000937 H-loop/switch region; other site 515635000938 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 515635000939 Acyltransferase family; Region: Acyl_transf_3; cl19154 515635000940 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 515635000941 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 515635000942 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 515635000943 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 515635000944 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 515635000945 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 515635000946 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 515635000947 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 515635000948 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 515635000949 active site 515635000950 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 515635000951 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 515635000952 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 515635000953 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 515635000954 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 515635000955 active site 515635000956 FMN binding site [chemical binding]; other site 515635000957 substrate binding site [chemical binding]; other site 515635000958 3Fe-4S cluster binding site [ion binding]; other site 515635000959 Glucuronate isomerase; Region: UxaC; pfam02614 515635000960 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 515635000961 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 515635000962 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 515635000963 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 515635000964 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 515635000965 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 515635000966 dimer interface [polypeptide binding]; other site 515635000967 ABC-ATPase subunit interface; other site 515635000968 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 515635000969 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 515635000970 dimer interface [polypeptide binding]; other site 515635000971 conserved gate region; other site 515635000972 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 515635000973 ABC-ATPase subunit interface; other site 515635000974 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 515635000975 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 515635000976 active site 515635000977 phosphorylation site [posttranslational modification] 515635000978 intermolecular recognition site; other site 515635000979 dimerization interface [polypeptide binding]; other site 515635000980 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 515635000981 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 515635000982 Alpha-L-fucosidase; Region: Alpha_L_fucos; smart00812 515635000983 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 515635000984 HEPN domain; Region: HEPN; pfam05168 515635000985 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 515635000986 active site 515635000987 NTP binding site [chemical binding]; other site 515635000988 metal binding triad [ion binding]; metal-binding site 515635000989 antibiotic binding site [chemical binding]; other site 515635000990 putative alpha-glucosidase; Provisional; Region: PRK10658 515635000991 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 515635000992 YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593 515635000993 active site 515635000994 homotrimer interface [polypeptide binding]; other site 515635000995 catalytic site [active] 515635000996 homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site 515635000997 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 515635000998 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 515635000999 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 515635001000 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 515635001001 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 515635001002 Phosphopantothenoylcysteine synthetase/decarboxylase [Coenzyme metabolism]; Region: Dfp; COG0452 515635001003 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 515635001004 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 515635001005 FeS/SAM binding site; other site 515635001006 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 515635001007 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 515635001008 NADP binding site [chemical binding]; other site 515635001009 active site 515635001010 putative substrate binding site [chemical binding]; other site 515635001011 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 515635001012 hexamer (dimer of trimers) interface [polypeptide binding]; other site 515635001013 substrate binding site [chemical binding]; other site 515635001014 trimer interface [polypeptide binding]; other site 515635001015 Mn binding site [ion binding]; other site 515635001016 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 515635001017 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH1; cd08185 515635001018 putative active site [active] 515635001019 metal binding site [ion binding]; metal-binding site 515635001020 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 515635001021 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 515635001022 active site 515635001023 membrane protein; Provisional; Region: PRK14404 515635001024 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 515635001025 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 515635001026 active site 515635001027 membrane protein; Provisional; Region: PRK14404 515635001028 OsmC-like protein; Region: OsmC; pfam02566 515635001029 Tfp pilus assembly protein PilV [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilV; COG4967 515635001030 Lamin Tail Domain; Region: LTD; pfam00932 515635001031 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 515635001032 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 515635001033 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 515635001034 putative RNA binding site [nucleotide binding]; other site 515635001035 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 515635001036 S-adenosylmethionine binding site [chemical binding]; other site 515635001037 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 515635001038 Zn2+ binding site [ion binding]; other site 515635001039 Mg2+ binding site [ion binding]; other site 515635001040 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 515635001041 Zn2+ binding site [ion binding]; other site 515635001042 Mg2+ binding site [ion binding]; other site 515635001043 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 515635001044 putative FMN binding site [chemical binding]; other site 515635001045 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 515635001046 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 515635001047 active site 515635001048 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 515635001049 active site 515635001050 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 515635001051 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 515635001052 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 515635001053 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 515635001054 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 515635001055 Glycosyl transferase 4-like domain; Region: Glyco_trans_4_4; cl17183 515635001056 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 515635001057 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 515635001058 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 515635001059 NAD(P) binding site [chemical binding]; other site 515635001060 active site 515635001061 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 515635001062 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 515635001063 NAD(P) binding site [chemical binding]; other site 515635001064 active site 515635001065 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 515635001066 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 515635001067 active site 515635001068 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 515635001069 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 515635001070 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 515635001071 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 515635001072 MMPL family; Region: MMPL; cl14618 515635001073 MMPL family; Region: MMPL; cl14618 515635001074 Putative small multi-drug export protein; Region: Sm_multidrug_ex; pfam06695 515635001075 beta subunit of N-acylethanolamine-hydrolyzing acid amidase; Region: NAAA-beta; pfam15508 515635001076 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 515635001077 active site 515635001078 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 515635001079 putative phosphoketolase; Provisional; Region: PRK05261 515635001080 XFP N-terminal domain; Region: XFP_N; pfam09364 515635001081 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 515635001082 XFP C-terminal domain; Region: XFP_C; pfam09363 515635001083 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 515635001084 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 515635001085 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 515635001086 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 515635001087 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 515635001088 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 515635001089 nucleotide binding site [chemical binding]; other site 515635001090 Glycoside-hydrolase family GH114; Region: Glyco_hydro_114; cl00997 515635001091 CARDB; Region: CARDB; pfam07705 515635001092 CARDB; Region: CARDB; pfam07705 515635001093 DOMON-like type 9 carbohydrate binding module; Region: CBM9_like_4; cd09619 515635001094 putative ligand binding site [chemical binding]; other site 515635001095 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 515635001096 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 515635001097 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 515635001098 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 515635001099 dimer interface [polypeptide binding]; other site 515635001100 conserved gate region; other site 515635001101 putative PBP binding loops; other site 515635001102 ABC-ATPase subunit interface; other site 515635001103 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 515635001104 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 515635001105 dimer interface [polypeptide binding]; other site 515635001106 conserved gate region; other site 515635001107 putative PBP binding loops; other site 515635001108 ABC-ATPase subunit interface; other site 515635001109 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 515635001110 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 515635001111 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 515635001112 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 515635001113 dimer interface [polypeptide binding]; other site 515635001114 active site 515635001115 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 515635001116 dimer interface [polypeptide binding]; other site 515635001117 active site 515635001118 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 515635001119 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 515635001120 dimerization interface [polypeptide binding]; other site 515635001121 putative Zn2+ binding site [ion binding]; other site 515635001122 putative DNA binding site [nucleotide binding]; other site 515635001123 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 515635001124 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 515635001125 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 515635001126 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 515635001127 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 515635001128 dimer interface [polypeptide binding]; other site 515635001129 conserved gate region; other site 515635001130 putative PBP binding loops; other site 515635001131 ABC-ATPase subunit interface; other site 515635001132 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 515635001133 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 515635001134 dimer interface [polypeptide binding]; other site 515635001135 conserved gate region; other site 515635001136 putative PBP binding loops; other site 515635001137 ABC-ATPase subunit interface; other site 515635001138 alpha-galactosidase; Provisional; Region: PRK15076 515635001139 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 515635001140 NAD binding site [chemical binding]; other site 515635001141 sugar binding site [chemical binding]; other site 515635001142 divalent metal binding site [ion binding]; other site 515635001143 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 515635001144 dimer interface [polypeptide binding]; other site 515635001145 Tagatose 6 phosphate kinase; Region: Tagatose_6_P_K; cl09211 515635001146 GCN5-like protein 1 (GCN5L1); Region: GCN5L1; pfam06320 515635001147 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 515635001148 substrate binding site [chemical binding]; other site 515635001149 ATP binding site [chemical binding]; other site 515635001150 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 515635001151 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 515635001152 NAD(P) binding site [chemical binding]; other site 515635001153 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 515635001154 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 515635001155 Walker A/P-loop; other site 515635001156 ATP binding site [chemical binding]; other site 515635001157 Q-loop/lid; other site 515635001158 ABC transporter signature motif; other site 515635001159 Walker B; other site 515635001160 D-loop; other site 515635001161 H-loop/switch region; other site 515635001162 FtsX-like permease family; Region: FtsX; pfam02687 515635001163 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 515635001164 FtsX-like permease family; Region: FtsX; pfam02687 515635001165 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB2; cd01048 515635001166 diiron binding motif [ion binding]; other site 515635001167 hypothetical protein; Provisional; Region: nrdC.11; PHA02603 515635001168 Zinc dependent phospholipase C/S1-P1 nuclease; Region: ZnPC_S1P1; cl16915 515635001169 Predicted GTPase or GTP-binding protein [General function prediction only]; Region: COG1341 515635001170 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 515635001171 Oligomerization domain; Region: Oligomerization; pfam02410 515635001172 Transcriptional regulator [Transcription]; Region: LytR; COG1316 515635001173 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 515635001174 Protein of unknown function (DUF4038); Region: DUF4038; pfam13204 515635001175 Putative collagen-binding domain of a collagenase; Region: Collagen_bind_2; pfam12904 515635001176 Pyruvate-formate lyase-activating enzyme [Posttranslational modification, protein turnover, chaperones]; Region: PflA; COG1180 515635001177 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 515635001178 FeS/SAM binding site; other site 515635001179 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303 515635001180 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 515635001181 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 515635001182 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 515635001183 catalytic triad [active] 515635001184 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 515635001185 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 515635001186 FMN binding site [chemical binding]; other site 515635001187 substrate binding site [chemical binding]; other site 515635001188 putative catalytic residue [active] 515635001189 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 515635001190 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 515635001191 NAD binding site [chemical binding]; other site 515635001192 homotetramer interface [polypeptide binding]; other site 515635001193 homodimer interface [polypeptide binding]; other site 515635001194 substrate binding site [chemical binding]; other site 515635001195 active site 515635001196 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 515635001197 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 515635001198 putative DNA binding site [nucleotide binding]; other site 515635001199 putative Zn2+ binding site [ion binding]; other site 515635001200 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 515635001201 Transcriptional regulators [Transcription]; Region: PurR; COG1609 515635001202 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 515635001203 DNA binding site [nucleotide binding] 515635001204 domain linker motif; other site 515635001205 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 515635001206 dimerization interface [polypeptide binding]; other site 515635001207 ligand binding site [chemical binding]; other site 515635001208 L-fucose isomerase; Provisional; Region: fucI; PRK10991 515635001209 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 515635001210 hexamer (dimer of trimers) interface [polypeptide binding]; other site 515635001211 trimer interface [polypeptide binding]; other site 515635001212 substrate binding site [chemical binding]; other site 515635001213 Mn binding site [ion binding]; other site 515635001214 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 515635001215 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 515635001216 Walker A/P-loop; other site 515635001217 ATP binding site [chemical binding]; other site 515635001218 Q-loop/lid; other site 515635001219 ABC transporter signature motif; other site 515635001220 Walker B; other site 515635001221 D-loop; other site 515635001222 H-loop/switch region; other site 515635001223 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 515635001224 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 515635001225 TM-ABC transporter signature motif; other site 515635001226 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 515635001227 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_2; cd06310 515635001228 putative ligand binding site [chemical binding]; other site 515635001229 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 515635001230 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 515635001231 ligand binding site [chemical binding]; other site 515635001232 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 515635001233 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 515635001234 Walker A/P-loop; other site 515635001235 ATP binding site [chemical binding]; other site 515635001236 Q-loop/lid; other site 515635001237 ABC transporter signature motif; other site 515635001238 Walker B; other site 515635001239 D-loop; other site 515635001240 H-loop/switch region; other site 515635001241 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 515635001242 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 515635001243 TM-ABC transporter signature motif; other site 515635001244 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 515635001245 TM-ABC transporter signature motif; other site 515635001246 Anabaena sensory rhodopsin transducer; Region: ASRT; pfam07100 515635001247 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 515635001248 tetramer interface [polypeptide binding]; other site 515635001249 TPP-binding site [chemical binding]; other site 515635001250 heterodimer interface [polypeptide binding]; other site 515635001251 phosphorylation loop region [posttranslational modification] 515635001252 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 515635001253 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 515635001254 alpha subunit interface [polypeptide binding]; other site 515635001255 TPP binding site [chemical binding]; other site 515635001256 heterodimer interface [polypeptide binding]; other site 515635001257 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 515635001258 L-sorbose-1-phosphate reductase; Region: sorbose_phosphate_red; cd08238 515635001259 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 515635001260 putative NAD(P) binding site [chemical binding]; other site 515635001261 catalytic Zn binding site [ion binding]; other site 515635001262 sorbitol-6-phosphate dehydrogenase; Provisional; Region: PRK12384 515635001263 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 515635001264 NAD(P) binding site [chemical binding]; other site 515635001265 active site 515635001266 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 515635001267 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 515635001268 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596 515635001269 intersubunit interface [polypeptide binding]; other site 515635001270 active site 515635001271 Zn2+ binding site [ion binding]; other site 515635001272 short chain dehydrogenase; Provisional; Region: PRK07326 515635001273 classical (c) SDRs; Region: SDR_c; cd05233 515635001274 NAD(P) binding site [chemical binding]; other site 515635001275 active site 515635001276 L-rhamnose isomerase, Streptomyces subtype; Region: RhaI_grampos; TIGR02635 515635001277 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 515635001278 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 515635001279 N- and C-terminal domain interface [polypeptide binding]; other site 515635001280 rhamnulokinase; Region: rhamnulo_kin; TIGR02627 515635001281 active site 515635001282 putative catalytic site [active] 515635001283 metal binding site [ion binding]; metal-binding site 515635001284 ATP binding site [chemical binding]; other site 515635001285 carbohydrate binding site [chemical binding]; other site 515635001286 Superoxide reductase-like (SORL) domain, class II; SORL-domains are present in a family of mononuclear non-heme iron proteins that includes superoxide reductase and desulfoferrodoxin. Superoxide reductase-like proteins scavenge superoxide anion radicals...; Region: SORL_classII; cd03172 515635001287 non-heme iron binding site [ion binding]; other site 515635001288 tetramer interface [polypeptide binding]; other site 515635001289 Amb_all domain; Region: Amb_all; smart00656 515635001290 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 515635001291 Interdomain contacts; other site 515635001292 Cytokine receptor motif; other site 515635001293 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 515635001294 Interdomain contacts; other site 515635001295 Cytokine receptor motif; other site 515635001296 Pectate lyase [Carbohydrate transport and metabolism]; Region: PelB; COG3866 515635001297 Amb_all domain; Region: Amb_all; smart00656 515635001298 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 515635001299 Interdomain contacts; other site 515635001300 Cytokine receptor motif; other site 515635001301 Pectinesterase; Region: Pectinesterase; cl01911 515635001302 Amb_all domain; Region: Amb_all; smart00656 515635001303 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 515635001304 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 515635001305 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 515635001306 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 515635001307 dimer interface [polypeptide binding]; other site 515635001308 conserved gate region; other site 515635001309 putative PBP binding loops; other site 515635001310 ABC-ATPase subunit interface; other site 515635001311 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 515635001312 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 515635001313 dimer interface [polypeptide binding]; other site 515635001314 conserved gate region; other site 515635001315 putative PBP binding loops; other site 515635001316 ABC-ATPase subunit interface; other site 515635001317 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 515635001318 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 515635001319 NAD binding site [chemical binding]; other site 515635001320 sugar binding site [chemical binding]; other site 515635001321 divalent metal binding site [ion binding]; other site 515635001322 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 515635001323 dimer interface [polypeptide binding]; other site 515635001324 cyclically-permuted mutarotase family protein; Region: mutarot_permut; TIGR03548 515635001325 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 515635001326 substrate binding site [chemical binding]; other site 515635001327 ATP binding site [chemical binding]; other site 515635001328 Transcriptional regulator [Transcription]; Region: IclR; COG1414 515635001329 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 515635001330 putative DNA binding site [nucleotide binding]; other site 515635001331 putative Zn2+ binding site [ion binding]; other site 515635001332 Bacterial transcriptional regulator; Region: IclR; pfam01614 515635001333 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 515635001334 dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318 515635001335 phosphate binding site [ion binding]; other site 515635001336 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 515635001337 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK06263 515635001338 L-aspartate oxidase; Provisional; Region: PRK06175 515635001339 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 515635001340 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 515635001341 Hypothetical enzyme TM0436 resembles the zinc-dependent alcohol dehydrogenases (ADH); Region: MDR_TM0436_like; cd08231 515635001342 catalytic Zn binding site [ion binding]; other site 515635001343 structural Zn binding site [ion binding]; other site 515635001344 tetramer interface [polypeptide binding]; other site 515635001345 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 515635001346 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 515635001347 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 515635001348 tetramer interface [polypeptide binding]; other site 515635001349 pyridoxal 5'-phosphate binding site [chemical binding]; other site 515635001350 catalytic residue [active] 515635001351 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 515635001352 Catalytic NodB homology domain of Clostridium thermocellum acetylxylan esterase and its bacterial homologs; Region: CE4_CtAXE_like; cd10954 515635001353 NodB motif; other site 515635001354 active site 515635001355 catalytic site [active] 515635001356 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 515635001357 Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273 515635001358 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 515635001359 active site 515635001360 catalytic residues [active] 515635001361 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 515635001362 Putative heavy-metal-binding; Region: YbjQ_1; pfam01906 515635001363 Membrane transport protein; Region: Mem_trans; cl09117 515635001364 Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148 515635001365 Ferredoxin [Energy production and conversion]; Region: COG1146 515635001366 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 515635001367 DGC domain; Region: DGC; pfam08859 515635001368 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 515635001369 dimerization interface [polypeptide binding]; other site 515635001370 putative DNA binding site [nucleotide binding]; other site 515635001371 putative Zn2+ binding site [ion binding]; other site 515635001372 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 515635001373 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 515635001374 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 515635001375 motif II; other site 515635001376 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 515635001377 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 515635001378 spore photoproduct lyase; Region: photo_TT_lyase; cl15393 515635001379 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 515635001380 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 515635001381 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 515635001382 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845 515635001383 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 515635001384 YvrJ protein family; Region: YvrJ; pfam12841 515635001385 Peptidase M15; Region: Peptidase_M15_3; cl01194 515635001386 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 515635001387 Protein of unknown function (DUF1659); Region: DUF1659; pfam07872 515635001388 conserved hypothetical protein; Region: TIGR02231 515635001389 Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348 515635001390 4Fe-4S binding domain; Region: Fer4_5; pfam12801 515635001391 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 515635001392 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 515635001393 Beta-Casp domain; Region: Beta-Casp; smart01027 515635001394 RNA-metabolizing metallo-beta-lactamase; Region: RMMBL; pfam07521 515635001395 Tho complex subunit THP2; Region: THP2; pfam09432 515635001396 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 515635001397 metal binding site [ion binding]; metal-binding site 515635001398 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 515635001399 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 515635001400 dimer interface [polypeptide binding]; other site 515635001401 conserved gate region; other site 515635001402 putative PBP binding loops; other site 515635001403 ABC-ATPase subunit interface; other site 515635001404 phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268 515635001405 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 515635001406 dimer interface [polypeptide binding]; other site 515635001407 conserved gate region; other site 515635001408 ABC-ATPase subunit interface; other site 515635001409 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 515635001410 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 515635001411 Walker A/P-loop; other site 515635001412 ATP binding site [chemical binding]; other site 515635001413 Q-loop/lid; other site 515635001414 ABC transporter signature motif; other site 515635001415 Walker B; other site 515635001416 D-loop; other site 515635001417 H-loop/switch region; other site 515635001418 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 515635001419 PhoU domain; Region: PhoU; pfam01895 515635001420 PhoU domain; Region: PhoU; pfam01895 515635001421 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 515635001422 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 515635001423 Transcriptional regulators [Transcription]; Region: GntR; COG1802 515635001424 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 515635001425 DNA-binding site [nucleotide binding]; DNA binding site 515635001426 FCD domain; Region: FCD; pfam07729 515635001427 Uncharacterized ALDH (y4uC) with similarity to Tortula ruralis aldehyde dehydrogenase ALDH21A1; Region: ALDH_y4uC; cd07149 515635001428 NAD(P) binding site [chemical binding]; other site 515635001429 catalytic residues [active] 515635001430 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 515635001431 active site 515635001432 intersubunit interactions; other site 515635001433 catalytic residue [active] 515635001434 Domain of unknown function (DUF2088); Region: DUF2088; cl15406 515635001435 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 515635001436 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 515635001437 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 515635001438 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 515635001439 dimer interface [polypeptide binding]; other site 515635001440 conserved gate region; other site 515635001441 putative PBP binding loops; other site 515635001442 ABC-ATPase subunit interface; other site 515635001443 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 515635001444 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 515635001445 dimer interface [polypeptide binding]; other site 515635001446 conserved gate region; other site 515635001447 putative PBP binding loops; other site 515635001448 ABC-ATPase subunit interface; other site 515635001449 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 515635001450 Glycosyl hydrolases family 31; Region: Glyco_hydro_31; pfam01055 515635001451 YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593 515635001452 active site 515635001453 homotrimer interface [polypeptide binding]; other site 515635001454 catalytic site [active] 515635001455 homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site 515635001456 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 515635001457 hexamer (dimer of trimers) interface [polypeptide binding]; other site 515635001458 substrate binding site [chemical binding]; other site 515635001459 trimer interface [polypeptide binding]; other site 515635001460 Mn binding site [ion binding]; other site 515635001461 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 515635001462 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 515635001463 Zn2+ binding site [ion binding]; other site 515635001464 Mg2+ binding site [ion binding]; other site 515635001465 short chain dehydrogenase; Provisional; Region: PRK07326 515635001466 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 515635001467 NAD(P) binding site [chemical binding]; other site 515635001468 active site 515635001469 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 515635001470 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 515635001471 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 515635001472 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 515635001473 Transcriptional regulators [Transcription]; Region: FadR; COG2186 515635001474 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 515635001475 DNA-binding site [nucleotide binding]; DNA binding site 515635001476 FCD domain; Region: FCD; pfam07729 515635001477 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 515635001478 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 515635001479 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 515635001480 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 515635001481 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 515635001482 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 515635001483 dimer interface [polypeptide binding]; other site 515635001484 conserved gate region; other site 515635001485 putative PBP binding loops; other site 515635001486 ABC-ATPase subunit interface; other site 515635001487 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 515635001488 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 515635001489 dimer interface [polypeptide binding]; other site 515635001490 conserved gate region; other site 515635001491 putative PBP binding loops; other site 515635001492 ABC-ATPase subunit interface; other site 515635001493 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 515635001494 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 515635001495 Transcriptional regulators [Transcription]; Region: PurR; COG1609 515635001496 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 515635001497 DNA binding site [nucleotide binding] 515635001498 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 515635001499 dimerization interface [polypeptide binding]; other site 515635001500 ligand binding site [chemical binding]; other site 515635001501 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 515635001502 CPxP motif; other site 515635001503 Sulphur transport; Region: Sulf_transp; cl19477 515635001504 Sulphur transport; Region: Sulf_transp; cl19477 515635001505 DsrE/DsrF-like family; Region: DrsE; cl00672 515635001506 DsrE/DsrF-like family; Region: DrsE; cl00672 515635001507 sulfur relay protein TusB/DsrH; Region: sulf_tusB_dsrH; TIGR03011 515635001508 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 515635001509 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 515635001510 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 515635001511 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 515635001512 Enterobacterial TraT complement resistance protein; Region: TraT; cl19728 515635001513 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 515635001514 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 515635001515 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 515635001516 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 515635001517 Walker A/P-loop; other site 515635001518 ATP binding site [chemical binding]; other site 515635001519 Q-loop/lid; other site 515635001520 ABC transporter signature motif; other site 515635001521 Walker B; other site 515635001522 D-loop; other site 515635001523 H-loop/switch region; other site 515635001524 TOBE domain; Region: TOBE_2; pfam08402 515635001525 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 515635001526 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 515635001527 dimer interface [polypeptide binding]; other site 515635001528 conserved gate region; other site 515635001529 putative PBP binding loops; other site 515635001530 ABC-ATPase subunit interface; other site 515635001531 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 515635001532 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 515635001533 dimer interface [polypeptide binding]; other site 515635001534 conserved gate region; other site 515635001535 putative PBP binding loops; other site 515635001536 ABC-ATPase subunit interface; other site 515635001537 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527 515635001538 Predicted acetyltransferase involved in intracellular survival and related acetyltransferases [General function prediction only]; Region: Eis; COG4552 515635001539 Sterol carrier protein domain; Region: SCP2_2; pfam13530 515635001540 Glyco_18 domain; Region: Glyco_18; smart00636 515635001541 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 515635001542 active site 515635001543 Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785 515635001544 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl19058 515635001545 active site 515635001546 dimer interface [polypeptide binding]; other site 515635001547 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 515635001548 Low molecular weight phosphatase family; Region: LMWPc; cd00115 515635001549 active site 515635001550 Protein of unknown function DUF86; Region: DUF86; cl01031 515635001551 Transcriptional regulator PadR-like family; Region: PadR; cl17335 515635001552 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 515635001553 cell division ATPase MinD, archaeal; Region: minD_arch; TIGR01969 515635001554 Walker A motif; other site 515635001555 This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. This...; Region: NifX_NifB; cd00562 515635001556 Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237 515635001557 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 515635001558 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 515635001559 active site 515635001560 phosphorylation site [posttranslational modification] 515635001561 intermolecular recognition site; other site 515635001562 dimerization interface [polypeptide binding]; other site 515635001563 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 515635001564 DNA binding site [nucleotide binding] 515635001565 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 515635001566 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 515635001567 dimer interface [polypeptide binding]; other site 515635001568 phosphorylation site [posttranslational modification] 515635001569 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 515635001570 ATP binding site [chemical binding]; other site 515635001571 Mg2+ binding site [ion binding]; other site 515635001572 G-X-G motif; other site 515635001573 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 515635001574 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 515635001575 Iron dependent repressor, metal binding and dimerization domain; Region: Fe_dep_repr_C; pfam02742 515635001576 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 515635001577 FeoA domain; Region: FeoA; pfam04023 515635001578 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 515635001579 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 515635001580 G1 box; other site 515635001581 GTP/Mg2+ binding site [chemical binding]; other site 515635001582 Switch I region; other site 515635001583 G2 box; other site 515635001584 G3 box; other site 515635001585 Switch II region; other site 515635001586 G4 box; other site 515635001587 G5 box; other site 515635001588 Nucleoside recognition; Region: Gate; pfam07670 515635001589 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 515635001590 Nucleoside recognition; Region: Gate; pfam07670 515635001591 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 515635001592 S-adenosylmethionine binding site [chemical binding]; other site 515635001593 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 515635001594 active site 515635001595 NTP binding site [chemical binding]; other site 515635001596 metal binding triad [ion binding]; metal-binding site 515635001597 antibiotic binding site [chemical binding]; other site 515635001598 Uncharacterized conserved protein [Function unknown]; Region: COG2445 515635001599 Transcriptional regulators [Transcription]; Region: PurR; COG1609 515635001600 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 515635001601 DNA binding site [nucleotide binding] 515635001602 domain linker motif; other site 515635001603 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 515635001604 dimerization interface [polypeptide binding]; other site 515635001605 ligand binding site [chemical binding]; other site 515635001606 sodium binding site [ion binding]; other site 515635001607 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 515635001608 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 515635001609 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 515635001610 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 515635001611 dimer interface [polypeptide binding]; other site 515635001612 conserved gate region; other site 515635001613 putative PBP binding loops; other site 515635001614 ABC-ATPase subunit interface; other site 515635001615 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 515635001616 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 515635001617 dimer interface [polypeptide binding]; other site 515635001618 conserved gate region; other site 515635001619 putative PBP binding loops; other site 515635001620 ABC-ATPase subunit interface; other site 515635001621 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 515635001622 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 515635001623 substrate binding [chemical binding]; other site 515635001624 active site 515635001625 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 515635001626 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 515635001627 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 515635001628 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 515635001629 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 515635001630 active site 515635001631 catalytic tetrad [active] 515635001632 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 515635001633 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 515635001634 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 515635001635 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 515635001636 Predicted Fe-S protein [General function prediction only]; Region: COG2000 515635001637 Putative Fe-S cluster; Region: FeS; cl17515 515635001638 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 515635001639 Thioredoxin-like [2Fe-2S] ferredoxin; Region: 2Fe-2S_thioredx; pfam01257 515635001640 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 515635001641 putative dimer interface [polypeptide binding]; other site 515635001642 [2Fe-2S] cluster binding site [ion binding]; other site 515635001643 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 515635001644 dimer interface [polypeptide binding]; other site 515635001645 [2Fe-2S] cluster binding site [ion binding]; other site 515635001646 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 515635001647 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 515635001648 SLBB domain; Region: SLBB; pfam10531 515635001649 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 515635001650 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 515635001651 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 515635001652 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 515635001653 catalytic loop [active] 515635001654 iron binding site [ion binding]; other site 515635001655 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 515635001656 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 515635001657 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 515635001658 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 515635001659 Iron hydrogenase small subunit; Region: Fe_hyd_SSU; pfam02256 515635001660 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 515635001661 dimer interface [polypeptide binding]; other site 515635001662 [2Fe-2S] cluster binding site [ion binding]; other site 515635001663 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 515635001664 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 515635001665 CoA binding domain; Region: CoA_binding; pfam02629 515635001666 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 515635001667 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 515635001668 Walker A/P-loop; other site 515635001669 ATP binding site [chemical binding]; other site 515635001670 Q-loop/lid; other site 515635001671 ABC transporter signature motif; other site 515635001672 Walker B; other site 515635001673 D-loop; other site 515635001674 H-loop/switch region; other site 515635001675 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 515635001676 dimer interface [polypeptide binding]; other site 515635001677 conserved gate region; other site 515635001678 putative PBP binding loops; other site 515635001679 ABC-ATPase subunit interface; other site 515635001680 Protein of unknown function (DUF3834); Region: DUF3834; pfam12916 515635001681 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 515635001682 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 515635001683 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 515635001684 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 515635001685 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 515635001686 Walker A/P-loop; other site 515635001687 ATP binding site [chemical binding]; other site 515635001688 Q-loop/lid; other site 515635001689 ABC transporter signature motif; other site 515635001690 Walker B; other site 515635001691 D-loop; other site 515635001692 H-loop/switch region; other site 515635001693 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 515635001694 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 515635001695 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 515635001696 Walker A/P-loop; other site 515635001697 ATP binding site [chemical binding]; other site 515635001698 Q-loop/lid; other site 515635001699 ABC transporter signature motif; other site 515635001700 Walker B; other site 515635001701 D-loop; other site 515635001702 H-loop/switch region; other site 515635001703 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 515635001704 Major Facilitator Superfamily; Region: MFS_1; pfam07690 515635001705 putative substrate translocation pore; other site 515635001706 peroxiredoxin; Provisional; Region: PRK13189 515635001707 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 515635001708 dimer interface [polypeptide binding]; other site 515635001709 decamer (pentamer of dimers) interface [polypeptide binding]; other site 515635001710 catalytic triad [active] 515635001711 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 515635001712 CoA binding domain; Region: CoA_binding; cl17356 515635001713 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 515635001714 NAD(P) binding site [chemical binding]; other site 515635001715 homodimer interface [polypeptide binding]; other site 515635001716 substrate binding site [chemical binding]; other site 515635001717 active site 515635001718 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 515635001719 active site 515635001720 UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350 515635001721 homodimer interface [polypeptide binding]; other site 515635001722 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; Region: UDPG_MGDP_dh_N; pfam03721 515635001723 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 515635001724 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 515635001725 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 515635001726 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 515635001727 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 515635001728 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 515635001729 Bacterial transferase hexapeptide (six repeats); Region: Hexapep; pfam00132 515635001730 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 515635001731 putative trimer interface [polypeptide binding]; other site 515635001732 putative active site [active] 515635001733 putative substrate binding site [chemical binding]; other site 515635001734 putative CoA binding site [chemical binding]; other site 515635001735 carbamoyl phosphate synthase-like protein; Provisional; Region: PRK12767 515635001736 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 515635001737 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 515635001738 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432 515635001739 active site 515635001740 Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u7; cd10931 515635001741 putative active site [active] 515635001742 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 515635001743 O-Antigen ligase; Region: Wzy_C; pfam04932 515635001744 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 515635001745 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 515635001746 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 515635001747 UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase [Cell envelope biogenesis, outer membrane]; Region: MurG; COG0707 515635001748 Bacterial sugar transferase; Region: Bac_transf; pfam02397 515635001749 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 515635001750 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 515635001751 carbamoyl phosphate synthase-like protein; Provisional; Region: PRK12767 515635001752 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 515635001753 HAD superfamily (subfamily IA) hydrolase, TIGR02253; Region: CTE7 515635001754 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 515635001755 motif II; other site 515635001756 Glycosyltransferase 4 (GT4) includes both eukaryotic and prokaryotic UDP-D-N-acetylhexosamine:polyprenol phosphate D-N-acetylhexosamine-1-phosphate transferases. They catalyze the transfer of a D-N-acetylhexosamine 1-phosphate to a membrane-bound...; Region: GT_MraY-like; cl10571 515635001757 lipopolysaccharide biosynthesis protein RfbH; Provisional; Region: PRK15407 515635001758 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 515635001759 inhibitor-cofactor binding pocket; inhibition site 515635001760 pyridoxal 5'-phosphate binding site [chemical binding]; other site 515635001761 catalytic residue [active] 515635001762 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG1848 515635001763 putative active site [active] 515635001764 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 515635001765 polysaccharide export protein EpsE; Region: EpsE; TIGR03028 515635001766 SLBB domain; Region: SLBB; pfam10531 515635001767 SLBB domain; Region: SLBB; pfam10531 515635001768 polysaccharide export protein EpsE; Region: EpsE; TIGR03028 515635001769 SLBB domain; Region: SLBB; pfam10531 515635001770 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 515635001771 polysaccharide export protein EpsE; Region: EpsE; TIGR03028 515635001772 SLBB domain; Region: SLBB; pfam10531 515635001773 SLBB domain; Region: SLBB; pfam10531 515635001774 SLBB domain; Region: SLBB; pfam10531 515635001775 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 515635001776 SLBB domain; Region: SLBB; pfam10531 515635001777 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 515635001778 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 515635001779 Putative lysophospholipase; Region: Hydrolase_4; cl19140 515635001780 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 515635001781 Uncharacterized conserved protein [Function unknown]; Region: COG2135 515635001782 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 515635001783 M6 family metalloprotease domain; Region: M6dom_TIGR03296 515635001784 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 515635001785 Interdomain contacts; other site 515635001786 Cytokine receptor motif; other site 515635001787 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 515635001788 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 515635001789 Protein of unknown function DUF89; Region: DUF89; cl15397 515635001790 CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cl17439 515635001791 CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cd09728 515635001792 CRISPR/Cas system-associated RAMP superfamily protein Csm5; Region: Csm5_III-A; cl17437 515635001793 CRISPR/Cas system-associated RAMP superfamily protein Csm4; Region: Csm4_III-A; cl17438 515635001794 CRISPR/Cas system-associated RAMP superfamily protein Csm3; Region: Csm3_III-A; cl18986 515635001795 CRISPR/Cas system-associated protein Csm2; Region: Csm2_III-A; cl00622 515635001796 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cd09680 515635001797 CRISPR-associated protein Cas10/Csm1, subtype III-A/MTUBE; Region: cas_TM1811_Csm1; TIGR02578 515635001798 CRISPR/Cas system-associated protein Csx3; Region: Csx3_III-U; cl09837 515635001799 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 515635001800 active site 515635001801 putative GTP cyclohydrolase; Provisional; Region: PRK13674 515635001802 Dihydropteroate synthase and related enzymes [Coenzyme metabolism]; Region: FolP; COG0294 515635001803 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 515635001804 substrate binding pocket [chemical binding]; other site 515635001805 dimer interface [polypeptide binding]; other site 515635001806 inhibitor binding site; inhibition site 515635001807 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 515635001808 catalytic center binding site [active] 515635001809 ATP binding site [chemical binding]; other site 515635001810 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 515635001811 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-B; cd09722 515635001812 Domain of unknown function DUF83; Region: Cas_Cas4; pfam01930 515635001813 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 515635001814 CRISPR/Cas system-associated protein Cas3; Region: Cas3_I; cd09639 515635001815 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 515635001816 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-B; cl18994 515635001817 Family of unknown function (DUF694); Region: DUF694; pfam05107 515635001818 CRISPR/Cas system-associated protein Cas8a1; Region: Cas8a1_I-A; cl19018 515635001819 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6_I-A; cd09759 515635001820 Creatinine amidohydrolase; Region: Creatininase; cl00618 515635001821 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 515635001822 metal binding site [ion binding]; metal-binding site 515635001823 active site 515635001824 I-site; other site 515635001825 Glycosyl hydrolase family 12; Region: Glyco_hydro_12; cl03302 515635001826 Glycosyl hydrolase family 26; Region: Glyco_hydro_26; pfam02156 515635001827 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 515635001828 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298 515635001829 putative NAD(P) binding site [chemical binding]; other site 515635001830 putative substrate binding site [chemical binding]; other site 515635001831 catalytic Zn binding site [ion binding]; other site 515635001832 structural Zn binding site [ion binding]; other site 515635001833 Predicted transcriptional regulators [Transcription]; Region: COG1725 515635001834 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 515635001835 DNA-binding site [nucleotide binding]; DNA binding site 515635001836 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 515635001837 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 515635001838 Walker A/P-loop; other site 515635001839 ATP binding site [chemical binding]; other site 515635001840 Q-loop/lid; other site 515635001841 ABC transporter signature motif; other site 515635001842 Walker B; other site 515635001843 D-loop; other site 515635001844 H-loop/switch region; other site 515635001845 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 515635001846 Predicted GTPase [General function prediction only]; Region: DRG; COG1163 515635001847 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 515635001848 G1 box; other site 515635001849 GTP/Mg2+ binding site [chemical binding]; other site 515635001850 G2 box; other site 515635001851 Switch I region; other site 515635001852 G3 box; other site 515635001853 Switch II region; other site 515635001854 G4 box; other site 515635001855 G5 box; other site 515635001856 The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information...; Region: TGS; cl15768 515635001857 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 515635001858 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 515635001859 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 515635001860 Transcriptional regulators [Transcription]; Region: MarR; COG1846 515635001861 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 515635001862 putative DNA binding site [nucleotide binding]; other site 515635001863 putative Zn2+ binding site [ion binding]; other site 515635001864 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 515635001865 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 515635001866 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 515635001867 Walker A/P-loop; other site 515635001868 ATP binding site [chemical binding]; other site 515635001869 Q-loop/lid; other site 515635001870 ABC transporter signature motif; other site 515635001871 Walker B; other site 515635001872 D-loop; other site 515635001873 H-loop/switch region; other site 515635001874 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 515635001875 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 515635001876 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 515635001877 Walker A/P-loop; other site 515635001878 ATP binding site [chemical binding]; other site 515635001879 Q-loop/lid; other site 515635001880 ABC transporter signature motif; other site 515635001881 Walker B; other site 515635001882 D-loop; other site 515635001883 H-loop/switch region; other site 515635001884 DOMON-like type 9 carbohydrate binding module of xylanases; Region: CBM9_like_1; cd00005 515635001885 Ca binding site [ion binding]; other site 515635001886 carbohydrate binding site [chemical binding]; other site 515635001887 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 515635001888 EamA-like transporter family; Region: EamA; pfam00892 515635001889 EamA-like transporter family; Region: EamA; pfam00892 515635001890 KduI/IolB family; Region: KduI; pfam04962 515635001891 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 515635001892 Entner-Doudoroff aldolase; Region: eda; TIGR01182 515635001893 active site 515635001894 intersubunit interface [polypeptide binding]; other site 515635001895 catalytic residue [active] 515635001896 N-terminal domain of chitobiose phosphorylase (ChBP) and similar proteins; Region: GH94N_ChBP_like; cd11755 515635001897 catalytic domain interface [polypeptide binding]; other site 515635001898 putative homodimer interface [polypeptide binding]; other site 515635001899 Amylo-alpha-1,6-glucosidase; Region: GDE_C; cl19168 515635001900 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 515635001901 N-terminal domain of cellobiose phosphorylase (CBP) and similar proteins; Region: GH94N_CBP_like; cd11754 515635001902 catalytic domain interface [polypeptide binding]; other site 515635001903 homodimer interface [polypeptide binding]; other site 515635001904 putative active site [active] 515635001905 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 515635001906 Glycosyl hydrolases family 31; Region: Glyco_hydro_31; pfam01055 515635001907 Alpha-glucosidase II (alpha-D-glucoside glucohydrolase) is a glycosyl hydrolase family 31 (GH31) enzyme, found in bacteria and plants, which has exo-alpha-1,4-glucosidase and oligo-1,6-glucosidase activities. Alpha-glucosidase II has been characterized...; Region: GH31_glucosidase_II_MalA; cd06604 515635001908 trimer interface [polypeptide binding]; other site 515635001909 active site 515635001910 homohexamer (dimer of homotrimer) interface [polypeptide binding]; other site 515635001911 catalytic site [active] 515635001912 H+ Antiporter protein; Region: 2A0121; TIGR00900 515635001913 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 515635001914 putative substrate translocation pore; other site 515635001915 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 515635001916 dimerization interface [polypeptide binding]; other site 515635001917 putative active cleft [active] 515635001918 GIY-YIG domain of hypothetical proteins from archaea and their bacterial homologs; Region: GIY-YIG_COG1833; cd10441 515635001919 GIY-YIG motif/motif A; other site 515635001920 putative active site [active] 515635001921 putative metal binding site [ion binding]; other site 515635001922 LysE type translocator; Region: LysE; cl00565 515635001923 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 515635001924 putative active site [active] 515635001925 putative metal binding site [ion binding]; other site 515635001926 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 515635001927 active site 515635001928 BioY family; Region: BioY; pfam02632 515635001929 Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983 515635001930 Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983 515635001931 Transcriptional regulators [Transcription]; Region: PurR; COG1609 515635001932 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 515635001933 DNA binding site [nucleotide binding] 515635001934 domain linker motif; other site 515635001935 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 515635001936 dimerization interface [polypeptide binding]; other site 515635001937 ligand binding site [chemical binding]; other site 515635001938 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 515635001939 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 515635001940 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 515635001941 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 515635001942 dimer interface [polypeptide binding]; other site 515635001943 conserved gate region; other site 515635001944 putative PBP binding loops; other site 515635001945 ABC-ATPase subunit interface; other site 515635001946 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 515635001947 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 515635001948 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 515635001949 dimer interface [polypeptide binding]; other site 515635001950 conserved gate region; other site 515635001951 putative PBP binding loops; other site 515635001952 ABC-ATPase subunit interface; other site 515635001953 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 515635001954 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 515635001955 Walker A/P-loop; other site 515635001956 ATP binding site [chemical binding]; other site 515635001957 Q-loop/lid; other site 515635001958 ABC transporter signature motif; other site 515635001959 Walker B; other site 515635001960 D-loop; other site 515635001961 H-loop/switch region; other site 515635001962 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 515635001963 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 515635001964 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 515635001965 Walker A/P-loop; other site 515635001966 ATP binding site [chemical binding]; other site 515635001967 Q-loop/lid; other site 515635001968 ABC transporter signature motif; other site 515635001969 Walker B; other site 515635001970 D-loop; other site 515635001971 H-loop/switch region; other site 515635001972 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 515635001973 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 515635001974 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 515635001975 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 515635001976 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 515635001977 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 515635001978 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 515635001979 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 515635001980 Walker A/P-loop; other site 515635001981 ATP binding site [chemical binding]; other site 515635001982 Q-loop/lid; other site 515635001983 ABC transporter signature motif; other site 515635001984 Walker B; other site 515635001985 D-loop; other site 515635001986 H-loop/switch region; other site 515635001987 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 515635001988 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 515635001989 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 515635001990 Walker A/P-loop; other site 515635001991 ATP binding site [chemical binding]; other site 515635001992 Q-loop/lid; other site 515635001993 ABC transporter signature motif; other site 515635001994 Walker B; other site 515635001995 D-loop; other site 515635001996 H-loop/switch region; other site 515635001997 Alpha-amylase/alpha-mannosidase [Carbohydrate transport and metabolism]; Region: COG1449 515635001998 N-terminal catalytic domain of thermoactive amylopullulanases; glycoside hydrolase family 57 (GH57); Region: GH57N_APU; cd10796 515635001999 putative active site [active] 515635002000 catalytic site [active] 515635002001 DOMON-like domain of various glycoside hydrolases; Region: DOMON_glucodextranase_like; cd09626 515635002002 putative ligand binding site [chemical binding]; other site 515635002003 DOMON-like domain of various glycoside hydrolases; Region: DOMON_glucodextranase_like; cd09626 515635002004 putative ligand binding site [chemical binding]; other site 515635002005 Domain of unknown function (DUF955); Region: DUF955; cl01076 515635002006 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 515635002007 non-specific DNA binding site [nucleotide binding]; other site 515635002008 salt bridge; other site 515635002009 sequence-specific DNA binding site [nucleotide binding]; other site 515635002010 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 515635002011 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 515635002012 oligomer interface [polypeptide binding]; other site 515635002013 active site 515635002014 metal binding site [ion binding]; metal-binding site 515635002015 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 515635002016 oligomer interface [polypeptide binding]; other site 515635002017 active site 515635002018 metal binding site [ion binding]; metal-binding site 515635002019 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 515635002020 oligomer interface [polypeptide binding]; other site 515635002021 active site 515635002022 metal binding site [ion binding]; metal-binding site 515635002023 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 515635002024 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 515635002025 minor groove reading motif; other site 515635002026 helix-hairpin-helix signature motif; other site 515635002027 substrate binding pocket [chemical binding]; other site 515635002028 active site 515635002029 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 515635002030 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 515635002031 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 515635002032 active site 515635002033 catalytic tetrad [active] 515635002034 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 515635002035 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 515635002036 L-threonine dehydrogenase; Region: threonine_DH_like; cd08234 515635002037 putative NAD(P) binding site [chemical binding]; other site 515635002038 catalytic Zn binding site [ion binding]; other site 515635002039 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 515635002040 putative phosphoesterase; Region: acc_ester; TIGR03729 515635002041 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 515635002042 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 515635002043 putative DNA binding site [nucleotide binding]; other site 515635002044 putative Zn2+ binding site [ion binding]; other site 515635002045 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 515635002046 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 515635002047 nucleotide binding site [chemical binding]; other site 515635002048 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 515635002049 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 515635002050 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 515635002051 Ligand Binding Site [chemical binding]; other site 515635002052 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 515635002053 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 515635002054 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 515635002055 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 515635002056 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 515635002057 glutamine binding [chemical binding]; other site 515635002058 catalytic triad [active] 515635002059 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 515635002060 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 515635002061 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 515635002062 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 515635002063 active site 515635002064 ribulose/triose binding site [chemical binding]; other site 515635002065 phosphate binding site [ion binding]; other site 515635002066 substrate (anthranilate) binding pocket [chemical binding]; other site 515635002067 product (indole) binding pocket [chemical binding]; other site 515635002068 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 515635002069 active site 515635002070 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 515635002071 pyridoxal 5'-phosphate binding site [chemical binding]; other site 515635002072 catalytic residue [active] 515635002073 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 515635002074 substrate binding site [chemical binding]; other site 515635002075 active site 515635002076 catalytic residues [active] 515635002077 heterodimer interface [polypeptide binding]; other site 515635002078 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 515635002079 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 515635002080 NAD(P) binding site [chemical binding]; other site 515635002081 Formiminotransferase-cyclodeaminase; Region: FTCD_C; pfam04961 515635002082 8-amino-7-oxononanoate synthase; Region: bioF; TIGR00858 515635002083 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 515635002084 substrate-cofactor binding pocket; other site 515635002085 pyridoxal 5'-phosphate binding site [chemical binding]; other site 515635002086 catalytic residue [active] 515635002087 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 515635002088 A subgroup of L-lactate dehydrogenases; Region: LDH_2; cd05292 515635002089 NAD binding site [chemical binding]; other site 515635002090 dimer interface [polypeptide binding]; other site 515635002091 substrate binding site [chemical binding]; other site 515635002092 tetramer (dimer of dimers) interface [polypeptide binding]; other site 515635002093 KaiC domain protein, AF_0795 family; Region: thermo_KaiC_2; TIGR03878 515635002094 RecA-superfamily ATPases implicated in signal transduction [Signal transduction mechanisms]; Region: RAD55; COG0467 515635002095 Walker A motif; other site 515635002096 ATP binding site [chemical binding]; other site 515635002097 Walker B motif; other site 515635002098 probable regulatory domain; Region: near_KaiC_dom; TIGR03879 515635002099 Predicted RNA-binding protein, contains TRAM domain [General function prediction only]; Region: COG3269 515635002100 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 515635002101 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 515635002102 S-adenosylmethionine binding site [chemical binding]; other site 515635002103 MoxR-like ATPases [General function prediction only]; Region: COG0714 515635002104 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 515635002105 Walker A motif; other site 515635002106 ATP binding site [chemical binding]; other site 515635002107 Walker B motif; other site 515635002108 arginine finger; other site 515635002109 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 515635002110 Protein of unknown function DUF58; Region: DUF58; pfam01882 515635002111 Protein of unknown function (DUF1498); Region: DUF1498; cl17840 515635002112 Ribonuclease HIII [DNA replication, recombination, and repair]; Region: RnhC; COG1039 515635002113 Ribonuclease H-like superfamily, including RNase H, HI, HII, HIII, and RNase-like domain IV of spliceosomal protein Prp8; Region: RNase_H_like; cl14782 515635002114 RNA/DNA hybrid binding site [nucleotide binding]; other site 515635002115 active site 515635002116 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 515635002117 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 515635002118 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 515635002119 dimer interface [polypeptide binding]; other site 515635002120 conserved gate region; other site 515635002121 putative PBP binding loops; other site 515635002122 ABC-ATPase subunit interface; other site 515635002123 maltose transporter membrane protein; Provisional; Region: malF; PRK10999 515635002124 Maltose transport system permease protein MalF P2 domain; Region: MalF_P2; pfam14785 515635002125 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 515635002126 dimer interface [polypeptide binding]; other site 515635002127 conserved gate region; other site 515635002128 putative PBP binding loops; other site 515635002129 ABC-ATPase subunit interface; other site 515635002130 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 515635002131 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 515635002132 Domain of unknown function (DUF4330); Region: DUF4330; pfam14221 515635002133 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 515635002134 O-antigen ligase like membrane protein; Region: O-antigen_lig; cl04850 515635002135 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 515635002136 putative active site [active] 515635002137 ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaE; COG2870 515635002138 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 515635002139 active site 515635002140 nucleotide binding site [chemical binding]; other site 515635002141 HIGH motif; other site 515635002142 KMSKS motif; other site 515635002143 ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaE; COG2870 515635002144 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 515635002145 putative ribose interaction site [chemical binding]; other site 515635002146 putative ADP binding site [chemical binding]; other site 515635002147 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 515635002148 dimer interface [polypeptide binding]; other site 515635002149 active site 515635002150 Histidinol phosphatase and related phosphatases [Amino acid transport and metabolism]; Region: HisB; COG0241 515635002151 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 515635002152 active site 515635002153 motif I; other site 515635002154 motif II; other site 515635002155 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 515635002156 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; Region: UDPG_MGDP_dh_N; pfam03721 515635002157 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 515635002158 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 515635002159 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 515635002160 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 515635002161 catalytic residue [active] 515635002162 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 515635002163 trimerization site [polypeptide binding]; other site 515635002164 active site 515635002165 Domain of unknown function DUF59; Region: DUF59; cl00941 515635002166 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 515635002167 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 515635002168 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 515635002169 binding surface 515635002170 TPR motif; other site 515635002171 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 515635002172 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 515635002173 binding surface 515635002174 TPR motif; other site 515635002175 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 515635002176 binding surface 515635002177 TPR motif; other site 515635002178 Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969 515635002179 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 515635002180 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 515635002181 Transcriptional regulators [Transcription]; Region: PurR; COG1609 515635002182 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 515635002183 DNA binding site [nucleotide binding] 515635002184 domain linker motif; other site 515635002185 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 515635002186 ligand binding site [chemical binding]; other site 515635002187 dimerization interface [polypeptide binding]; other site 515635002188 Predicted cobalamin binding protein [General function prediction only]; Region: COG5012 515635002189 B12 binding domain of corrinoid proteins. A family of small methanogenic corrinoid proteins that bind methyl-Co(III) 5-hydroxybenzimidazolylcobamide as a cofactor. They play a role on the methanogenesis from trimethylamine, dimethylamine or...; Region: corrinoid_protein_B12-BD; cd02070 515635002190 B12 binding site [chemical binding]; other site 515635002191 cobalt ligand [ion binding]; other site 515635002192 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 515635002193 Uncharacterized metal-binding protein [General function prediction only]; Region: COG3894 515635002194 catalytic loop [active] 515635002195 iron binding site [ion binding]; other site 515635002196 Domain of unknown function (DUF4445); Region: DUF4445; pfam14574 515635002197 The URO-D _like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases. Uroporphyrinogen decarboxylase (URO-D) decarboxylates the four...; Region: URO-D_like; cd03465 515635002198 Domain of unknown function DUF39; Region: DUF39; pfam01837 515635002199 putative methanogenesis marker 16 metalloprotein; Region: methan_mark_16; TIGR03287 515635002200 NIL domain; Region: NIL; pfam09383 515635002201 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 515635002202 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 515635002203 hypothetical protein; Provisional; Region: PRK04334 515635002204 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 515635002205 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 515635002206 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 515635002207 FtsX-like permease family; Region: FtsX; pfam02687 515635002208 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 515635002209 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 515635002210 HlyD family secretion protein; Region: HlyD_3; pfam13437 515635002211 Zinc dependent phospholipase C (alpha toxin); Region: Zn_dep_PLPC; cd11009 515635002212 Zn binding site [ion binding]; other site 515635002213 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 515635002214 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 515635002215 Walker A/P-loop; other site 515635002216 ATP binding site [chemical binding]; other site 515635002217 Q-loop/lid; other site 515635002218 ABC transporter signature motif; other site 515635002219 Walker B; other site 515635002220 D-loop; other site 515635002221 H-loop/switch region; other site 515635002222 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl19192 515635002223 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 515635002224 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 515635002225 Part of AAA domain; Region: AAA_19; pfam13245 515635002226 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 515635002227 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 515635002228 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 515635002229 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 515635002230 active site 515635002231 phosphorylation site [posttranslational modification] 515635002232 intermolecular recognition site; other site 515635002233 dimerization interface [polypeptide binding]; other site 515635002234 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 515635002235 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 515635002236 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 515635002237 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 515635002238 dimer interface [polypeptide binding]; other site 515635002239 phosphorylation site [posttranslational modification] 515635002240 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 515635002241 ATP binding site [chemical binding]; other site 515635002242 Mg2+ binding site [ion binding]; other site 515635002243 G-X-G motif; other site 515635002244 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 515635002245 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 515635002246 active site 515635002247 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 515635002248 B12-binding domain/radical SAM domain protein, MJ_1487 family; Region: B12_SAM_MJ_1487; TIGR04013 515635002249 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 515635002250 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 515635002251 FeS/SAM binding site; other site 515635002252 EamA-like transporter family; Region: EamA; pfam00892 515635002253 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 515635002254 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 515635002255 dimerization interface [polypeptide binding]; other site 515635002256 active site 515635002257 L-aspartate oxidase; Provisional; Region: PRK06175 515635002258 Aspartate oxidase [Coenzyme metabolism]; Region: NadB; COG0029 515635002259 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 515635002260 Quinolinate synthetase A protein; Region: NadA; pfam02445 515635002261 Protein of unknown function (DUF1049); Region: DUF1049; pfam06305 515635002262 propanediol utilization phosphotransacylase; Provisional; Region: PRK15070 515635002263 Propanediol utilisation protein PduL; Region: PduL; pfam06130 515635002264 Propanediol utilisation protein PduL; Region: PduL; pfam06130 515635002265 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 515635002266 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 515635002267 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 515635002268 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 515635002269 Glutaredoxin-like domain protein; Region: GlrX_arch; TIGR02187 515635002270 Thioredoxin (TRX)-Glutaredoxin (GRX)-like family; composed of archaeal and bacterial proteins that show similarity to both TRX and GRX, including the C-terminal TRX-fold subdomain of Pyrococcus furiosus protein disulfide oxidoreductase (PfPDO). All...; Region: TRX_GRX_like; cd02973 515635002271 catalytic residues [active] 515635002272 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 515635002273 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 515635002274 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 515635002275 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 515635002276 active site 515635002277 catalytic tetrad [active] 515635002278 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 515635002279 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 515635002280 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 515635002281 hypothetical protein; Provisional; Region: PRK13665 515635002282 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 515635002283 Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_like; cd07021 515635002284 dimer interface [polypeptide binding]; other site 515635002285 active site residues [active] 515635002286 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 515635002287 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 515635002288 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 515635002289 Walker A/P-loop; other site 515635002290 ATP binding site [chemical binding]; other site 515635002291 Q-loop/lid; other site 515635002292 ABC transporter signature motif; other site 515635002293 Walker B; other site 515635002294 D-loop; other site 515635002295 H-loop/switch region; other site 515635002296 C-terminal AAA-associated domain; Region: AAA_assoc_C; pfam09821 515635002297 ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism]; Region: COG4986 515635002298 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 515635002299 dimer interface [polypeptide binding]; other site 515635002300 conserved gate region; other site 515635002301 putative PBP binding loops; other site 515635002302 ABC-ATPase subunit interface; other site 515635002303 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 515635002304 dimer interface [polypeptide binding]; other site 515635002305 conserved gate region; other site 515635002306 putative PBP binding loops; other site 515635002307 ABC-ATPase subunit interface; other site 515635002308 N-terminal catalytic domain of thermoactive amylopullulanases; glycoside hydrolase family 57 (GH57); Region: GH57N_APU; cd10796 515635002309 putative active site [active] 515635002310 catalytic site [active] 515635002311 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 515635002312 Active_site [active] 515635002313 Protein of unknown function (DUF763); Region: DUF763; pfam05559 515635002314 Uncharacterized conserved protein [Function unknown]; Region: COG1430 515635002315 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 515635002316 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 515635002317 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 515635002318 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 515635002319 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045 515635002320 diiron binding motif [ion binding]; other site 515635002321 diaminopimelate epimerase; Provisional; Region: PRK13577 515635002322 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 515635002323 Diaminopimelate epimerase; Region: DAP_epimerase; cl19724 515635002324 ATP-dependent DNA ligase; Provisional; Region: PRK01109 515635002325 DNA ligase N terminus; Region: DNA_ligase_A_N; pfam04675 515635002326 Adenylation domain of archaeal and bacterial LigB-like DNA ligases; Region: Adenylation_DNA_ligase_Arch_LigB; cd07901 515635002327 active site 515635002328 DNA binding site [nucleotide binding] 515635002329 The Oligonucleotide/oligosaccharide binding (OB)-fold domain is a DNA-binding module that is part of the catalytic core unit of ATP dependent DNA ligases; Region: OBF_DNA_ligase; cd07893 515635002330 DNA binding site [nucleotide binding] 515635002331 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 515635002332 7TM-HD extracellular; Region: 7TMR-HDED; pfam07697 515635002333 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 515635002334 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 515635002335 Zn2+ binding site [ion binding]; other site 515635002336 Mg2+ binding site [ion binding]; other site 515635002337 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 515635002338 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 515635002339 Substrate binding site; other site 515635002340 Mg++ binding site; other site 515635002341 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 515635002342 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 515635002343 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 515635002344 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 515635002345 active site 515635002346 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 515635002347 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 515635002348 5S rRNA interface [nucleotide binding]; other site 515635002349 CTC domain interface [polypeptide binding]; other site 515635002350 L16 interface [polypeptide binding]; other site 515635002351 Ribosomal protein TL5, C-terminal domain; Region: Ribosomal_TL5_C; pfam14693 515635002352 EDD domain protein, DegV family; Region: DegV; TIGR00762 515635002353 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 515635002354 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 515635002355 Walker A motif; other site 515635002356 ATP binding site [chemical binding]; other site 515635002357 Walker B motif; other site 515635002358 R3H domain of a group of proteins with unknown function, who also contain a AAA-ATPase (AAA) domain. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. The function of the domain is...; Region: R3H_AAA; cd02645 515635002359 RxxxH motif; other site 515635002360 thymidylate kinase; Validated; Region: tmk; PRK00698 515635002361 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 515635002362 TMP-binding site; other site 515635002363 ATP-binding site [chemical binding]; other site 515635002364 Protein of unknown function (DUF970); Region: DUF970; cl17525 515635002365 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 515635002366 DNA polymerase III, delta' subunit; Region: holB; TIGR00678 515635002367 Walker A motif; other site 515635002368 ATP binding site [chemical binding]; other site 515635002369 Walker B motif; other site 515635002370 arginine finger; other site 515635002371 PSP1 C-terminal conserved region; Region: PSP1; cl00770 515635002372 recombination factor protein RarA; Reviewed; Region: PRK13342 515635002373 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 515635002374 Walker A motif; other site 515635002375 ATP binding site [chemical binding]; other site 515635002376 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 515635002377 Walker B motif; other site 515635002378 arginine finger; other site 515635002379 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 515635002380 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 515635002381 NodB motif; other site 515635002382 putative active site [active] 515635002383 putative catalytic site [active] 515635002384 Zn binding site [ion binding]; other site 515635002385 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 515635002386 Alpha amylase, catalytic domain; Region: Alpha-amylase; pfam00128 515635002387 active site 515635002388 catalytic site [active] 515635002389 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 515635002390 putative substrate binding site [chemical binding]; other site 515635002391 putative ATP binding site [chemical binding]; other site 515635002392 RIP metalloprotease RseP; Region: TIGR00054 515635002393 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 515635002394 active site 515635002395 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 515635002396 protein binding site [polypeptide binding]; other site 515635002397 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 515635002398 putative substrate binding region [chemical binding]; other site 515635002399 putative substrate binding region [chemical binding]; other site 515635002400 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 515635002401 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase; Region: ispG_gcpE; TIGR00612 515635002402 phosphodiesterase; Provisional; Region: PRK12704 515635002403 KH domain; Region: KH_1; pfam00013 515635002404 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 515635002405 Zn2+ binding site [ion binding]; other site 515635002406 Mg2+ binding site [ion binding]; other site 515635002407 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 515635002408 putative active site [active] 515635002409 metal binding site [ion binding]; metal-binding site 515635002410 homodimer binding site [polypeptide binding]; other site 515635002411 Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232 515635002412 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 515635002413 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 515635002414 thymidine kinase; Provisional; Region: PRK04296 515635002415 Protein of unknown function (DUF1385); Region: DUF1385; pfam07136 515635002416 peptide chain release factor 1; Validated; Region: prfA; PRK00591 515635002417 This domain is found in peptide chain release factors; Region: PCRF; smart00937 515635002418 RF-1 domain; Region: RF-1; pfam00472 515635002419 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 515635002420 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 515635002421 S-adenosylmethionine binding site [chemical binding]; other site 515635002422 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 515635002423 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 515635002424 Low molecular weight phosphatase family; Region: LMWPc; cd00115 515635002425 active site 515635002426 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 515635002427 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 515635002428 dimer interface [polypeptide binding]; other site 515635002429 active site 515635002430 glycine-pyridoxal phosphate binding site [chemical binding]; other site 515635002431 folate binding site [chemical binding]; other site 515635002432 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 515635002433 active site 515635002434 EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase); Region: EPSP_synthase; pfam00275 515635002435 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 515635002436 hinge; other site 515635002437 active site 515635002438 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 515635002439 Family of unknown function (DUF490); Region: DUF490; pfam04357 515635002440 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 515635002441 Outer membrane protein/protective antigen OMA87 [Cell envelope biogenesis, outer membrane]; Region: COG4775 515635002442 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 515635002443 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 515635002444 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 515635002445 Surface antigen; Region: Bac_surface_Ag; pfam01103 515635002446 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 515635002447 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 515635002448 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 515635002449 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 515635002450 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 515635002451 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 515635002452 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 515635002453 trimer interface [polypeptide binding]; other site 515635002454 active site 515635002455 UDP-GlcNAc binding site [chemical binding]; other site 515635002456 lipid binding site [chemical binding]; lipid-binding site 515635002457 UDP-3-O-acyl-N-acetylglucosamine deacetylase [Cell envelope biogenesis, outer membrane]; Region: LpxC; cl00512 515635002458 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 515635002459 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 515635002460 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 515635002461 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 515635002462 active site 515635002463 Lipid A disaccharide synthetase [Cell envelope biogenesis, outer membrane]; Region: LpxB; COG0763 515635002464 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 515635002465 Lipid A disaccharide synthetase [Cell envelope biogenesis, outer membrane]; Region: LpxB; COG0763 515635002466 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 515635002467 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 515635002468 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 515635002469 Walker A/P-loop; other site 515635002470 ATP binding site [chemical binding]; other site 515635002471 Q-loop/lid; other site 515635002472 ABC transporter signature motif; other site 515635002473 Walker B; other site 515635002474 D-loop; other site 515635002475 H-loop/switch region; other site 515635002476 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 515635002477 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 515635002478 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 515635002479 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 515635002480 binding surface 515635002481 TPR motif; other site 515635002482 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 515635002483 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 515635002484 Walker A/P-loop; other site 515635002485 ATP binding site [chemical binding]; other site 515635002486 Q-loop/lid; other site 515635002487 ABC transporter signature motif; other site 515635002488 Walker B; other site 515635002489 D-loop; other site 515635002490 H-loop/switch region; other site 515635002491 Protein of unknown function (DUF3084); Region: DUF3084; pfam11283 515635002492 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 515635002493 prolyl-tRNA synthetase; Provisional; Region: PRK08661 515635002494 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778 515635002495 dimer interface [polypeptide binding]; other site 515635002496 motif 1; other site 515635002497 active site 515635002498 motif 2; other site 515635002499 motif 3; other site 515635002500 ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862 515635002501 anticodon binding site; other site 515635002502 zinc-binding site [ion binding]; other site 515635002503 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 515635002504 trimer interface [polypeptide binding]; other site 515635002505 active site 515635002506 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 515635002507 elongation factor G; Reviewed; Region: PRK12740 515635002508 G1 box; other site 515635002509 putative GEF interaction site [polypeptide binding]; other site 515635002510 GTP/Mg2+ binding site [chemical binding]; other site 515635002511 Switch I region; other site 515635002512 G2 box; other site 515635002513 G3 box; other site 515635002514 Switch II region; other site 515635002515 G4 box; other site 515635002516 G5 box; other site 515635002517 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 515635002518 Elongation Factor G, domain II; Region: EFG_II; pfam14492 515635002519 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 515635002520 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 515635002521 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 515635002522 gamma-glutamyl kinase; Provisional; Region: PRK05429 515635002523 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 515635002524 nucleotide binding site [chemical binding]; other site 515635002525 homotetrameric interface [polypeptide binding]; other site 515635002526 putative phosphate binding site [ion binding]; other site 515635002527 putative allosteric binding site; other site 515635002528 PUA domain; Region: PUA; pfam01472 515635002529 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 515635002530 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 515635002531 Walker A/P-loop; other site 515635002532 ATP binding site [chemical binding]; other site 515635002533 Q-loop/lid; other site 515635002534 ABC transporter signature motif; other site 515635002535 Walker B; other site 515635002536 D-loop; other site 515635002537 H-loop/switch region; other site 515635002538 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 515635002539 Outer membrane efflux protein; Region: OEP; pfam02321 515635002540 Outer membrane efflux protein; Region: OEP; pfam02321 515635002541 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 515635002542 Outer membrane efflux protein; Region: OEP; pfam02321 515635002543 Outer membrane efflux protein; Region: OEP; pfam02321 515635002544 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 515635002545 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 515635002546 Outer membrane efflux protein; Region: OEP; pfam02321 515635002547 Tho complex subunit 7; Region: THOC7; pfam05615 515635002548 HlyD family secretion protein; Region: HlyD_3; pfam13437 515635002549 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 515635002550 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 515635002551 FtsX-like permease family; Region: FtsX; pfam02687 515635002552 BssS protein family; Region: BssS; cl08210 515635002553 glycerol kinase; Provisional; Region: glpK; PRK00047 515635002554 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 515635002555 N- and C-terminal domain interface [polypeptide binding]; other site 515635002556 active site 515635002557 MgATP binding site [chemical binding]; other site 515635002558 catalytic site [active] 515635002559 metal binding site [ion binding]; metal-binding site 515635002560 glycerol binding site [chemical binding]; other site 515635002561 homotetramer interface [polypeptide binding]; other site 515635002562 homodimer interface [polypeptide binding]; other site 515635002563 FBP binding site [chemical binding]; other site 515635002564 protein IIAGlc interface [polypeptide binding]; other site 515635002565 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cl01482 515635002566 dimer interface [polypeptide binding]; other site 515635002567 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 515635002568 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 515635002569 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 515635002570 DNA binding residues [nucleotide binding] 515635002571 Putative zinc-finger; Region: zf-HC2; pfam13490 515635002572 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl19192 515635002573 Uncharacterized protein related to Endonuclease III [DNA replication, recombination, and repair]; Region: COG2231 515635002574 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 515635002575 minor groove reading motif; other site 515635002576 helix-hairpin-helix signature motif; other site 515635002577 substrate binding pocket [chemical binding]; other site 515635002578 active site 515635002579 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 515635002580 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 515635002581 purine monophosphate binding site [chemical binding]; other site 515635002582 dimer interface [polypeptide binding]; other site 515635002583 putative catalytic residues [active] 515635002584 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 515635002585 Protein of unknown function (DUF1009); Region: DUF1009; cl09182 515635002586 Bifunctional nuclease; Region: DNase-RNase; pfam02577 515635002587 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 515635002588 EamA-like transporter family; Region: EamA; pfam00892 515635002589 Predicted membrane protein [Function unknown]; Region: COG3601 515635002590 EDD domain protein, DegV family; Region: DegV; TIGR00762 515635002591 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 515635002592 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 515635002593 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 515635002594 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 515635002595 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 515635002596 DNA-binding site [nucleotide binding]; DNA binding site 515635002597 Transcriptional regulators [Transcription]; Region: PurR; COG1609 515635002598 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 515635002599 ligand binding site [chemical binding]; other site 515635002600 dimerization interface [polypeptide binding]; other site 515635002601 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 515635002602 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 515635002603 maltose transporter membrane protein; Provisional; Region: malF; PRK10999 515635002604 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 515635002605 dimer interface [polypeptide binding]; other site 515635002606 conserved gate region; other site 515635002607 putative PBP binding loops; other site 515635002608 ABC-ATPase subunit interface; other site 515635002609 Spindle pole body component BBP1, C-terminal; Region: BBP1_C; pfam15272 515635002610 Laminin Domain I; Region: Laminin_I; pfam06008 515635002611 putative septicolysin, cholesterol-dependent cytolysin family and related proteins; Region: septicolysin_like; cd12208 515635002612 oligomer interface [polypeptide binding]; other site 515635002613 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 515635002614 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 515635002615 dimer interface [polypeptide binding]; other site 515635002616 conserved gate region; other site 515635002617 putative PBP binding loops; other site 515635002618 ABC-ATPase subunit interface; other site 515635002619 Glycosyl hydrolase family 53; Region: Glyco_hydro_53; cl06672 515635002620 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 515635002621 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 515635002622 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 515635002623 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 515635002624 peptide binding site [polypeptide binding]; other site 515635002625 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 515635002626 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 515635002627 dimer interface [polypeptide binding]; other site 515635002628 conserved gate region; other site 515635002629 putative PBP binding loops; other site 515635002630 ABC-ATPase subunit interface; other site 515635002631 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 515635002632 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 515635002633 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 515635002634 dimer interface [polypeptide binding]; other site 515635002635 conserved gate region; other site 515635002636 putative PBP binding loops; other site 515635002637 ABC-ATPase subunit interface; other site 515635002638 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 515635002639 active site 515635002640 dimer interfaces [polypeptide binding]; other site 515635002641 catalytic residues [active] 515635002642 S-layer homology domain; Region: SLH; pfam00395 515635002643 Family of unknown function (DUF566); Region: DUF566; pfam04484 515635002644 Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; Region: SPEC; cd00176 515635002645 linker region; other site 515635002646 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 515635002647 Baculovirus polyhedron envelope protein, PEP, C terminus; Region: Baculo_PEP_C; pfam04513 515635002648 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 515635002649 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 515635002650 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 515635002651 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 515635002652 pyridoxal 5'-phosphate binding site [chemical binding]; other site 515635002653 homodimer interface [polypeptide binding]; other site 515635002654 catalytic residue [active] 515635002655 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 515635002656 putative substrate binding site [chemical binding]; other site 515635002657 putative ATP binding site [chemical binding]; other site 515635002658 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 515635002659 binding surface 515635002660 TPR motif; other site 515635002661 TPR repeat; Region: TPR_11; pfam13414 515635002662 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 515635002663 binding surface 515635002664 TPR motif; other site 515635002665 Tetratricopeptide repeat; Region: TPR_16; pfam13432 515635002666 FtsH Extracellular; Region: FtsH_ext; pfam06480 515635002667 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 515635002668 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 515635002669 Walker A motif; other site 515635002670 ATP binding site [chemical binding]; other site 515635002671 Walker B motif; other site 515635002672 arginine finger; other site 515635002673 Peptidase family M41; Region: Peptidase_M41; pfam01434 515635002674 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 515635002675 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 515635002676 Ligand Binding Site [chemical binding]; other site 515635002677 TilS substrate C-terminal domain; Region: TilS_C; smart00977 515635002678 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 515635002679 dimerization interface [polypeptide binding]; other site 515635002680 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 515635002681 active site 515635002682 motif I; other site 515635002683 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 515635002684 motif II; other site 515635002685 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 515635002686 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 515635002687 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 515635002688 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 515635002689 Walker A motif; other site 515635002690 ATP binding site [chemical binding]; other site 515635002691 Walker B motif; other site 515635002692 Tfp pilus assembly protein, ATPase PilU [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilU; COG5008 515635002693 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 515635002694 Walker A motif; other site 515635002695 ATP binding site [chemical binding]; other site 515635002696 Walker B motif; other site 515635002697 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 515635002698 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 515635002699 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 515635002700 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 515635002701 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 515635002702 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 515635002703 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 515635002704 DNA binding residues [nucleotide binding] 515635002705 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 515635002706 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 515635002707 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 515635002708 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 515635002709 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 515635002710 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 515635002711 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 515635002712 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 515635002713 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 515635002714 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 515635002715 hypothetical protein; Reviewed; Region: PRK00024 515635002716 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 515635002717 MPN+ (JAMM) motif; other site 515635002718 Zinc-binding site [ion binding]; other site 515635002719 DNA polymerase I; Provisional; Region: PRK05755 515635002720 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 515635002721 active site 515635002722 metal binding site 1 [ion binding]; metal-binding site 515635002723 putative 5' ssDNA interaction site; other site 515635002724 metal binding site 3; metal-binding site 515635002725 metal binding site 2 [ion binding]; metal-binding site 515635002726 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 515635002727 putative DNA binding site [nucleotide binding]; other site 515635002728 putative metal binding site [ion binding]; other site 515635002729 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 515635002730 active site 515635002731 substrate binding site [chemical binding]; other site 515635002732 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 515635002733 active site 515635002734 DNA binding site [nucleotide binding] 515635002735 catalytic site [active] 515635002736 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 515635002737 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 515635002738 CoA-binding site [chemical binding]; other site 515635002739 excinuclease ABC subunit B; Provisional; Region: PRK05298 515635002740 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 515635002741 ATP binding site [chemical binding]; other site 515635002742 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 515635002743 nucleotide binding region [chemical binding]; other site 515635002744 ATP-binding site [chemical binding]; other site 515635002745 Ultra-violet resistance protein B; Region: UvrB; pfam12344 515635002746 UvrB/uvrC motif; Region: UVR; pfam02151 515635002747 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 515635002748 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 515635002749 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 515635002750 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 515635002751 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 515635002752 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 515635002753 DNA binding site [nucleotide binding] 515635002754 active site 515635002755 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 515635002756 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 515635002757 nucleotide binding site [chemical binding]; other site 515635002758 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 515635002759 CoA binding domain; Region: CoA_binding; cl17356 515635002760 Bacterial sugar transferase; Region: Bac_transf; pfam02397 515635002761 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 515635002762 active site 515635002763 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 515635002764 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 515635002765 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 515635002766 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 515635002767 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 515635002768 motif II; other site 515635002769 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 515635002770 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 515635002771 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 515635002772 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 515635002773 Walker A/P-loop; other site 515635002774 ATP binding site [chemical binding]; other site 515635002775 Q-loop/lid; other site 515635002776 ABC transporter signature motif; other site 515635002777 Walker B; other site 515635002778 D-loop; other site 515635002779 H-loop/switch region; other site 515635002780 TOBE domain; Region: TOBE_2; pfam08402 515635002781 Uncharacterized conserved protein [Function unknown]; Region: COG1543 515635002782 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 515635002783 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 515635002784 N-terminal catalytic domain of 4-alpha-glucanotransferase; glycoside hydrolase family 57 (GH57); Region: GH57N_TLGT_like; cd10793 515635002785 active site 515635002786 catalytic site [active] 515635002787 homodimer interface [polypeptide binding]; other site 515635002788 Lid 1; other site 515635002789 Domain of unknown function (DUF1925); Region: DUF1925; pfam09094 515635002790 Domain of unknown function (DUF1926); Region: DUF1926; pfam09095 515635002791 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 515635002792 active site 515635002793 dimerization interface [polypeptide binding]; other site 515635002794 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 515635002795 Clp amino terminal domain; Region: Clp_N; pfam02861 515635002796 Clp amino terminal domain; Region: Clp_N; pfam02861 515635002797 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 515635002798 Walker A motif; other site 515635002799 ATP binding site [chemical binding]; other site 515635002800 Walker B motif; other site 515635002801 arginine finger; other site 515635002802 CHD5-like protein; Region: CHD5; pfam04420 515635002803 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 515635002804 Walker A motif; other site 515635002805 ATP binding site [chemical binding]; other site 515635002806 Walker B motif; other site 515635002807 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 515635002808 Adenosine specific kinase; Region: Adenosine_kin; pfam04008 515635002809 Cytidylate kinase-like family; Region: Cytidylate_kin2; pfam13189 515635002810 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 515635002811 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 515635002812 PhoU domain; Region: PhoU; pfam01895 515635002813 PhoU domain; Region: PhoU; pfam01895 515635002814 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 515635002815 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 515635002816 homotetramer interface [polypeptide binding]; other site 515635002817 ligand binding site [chemical binding]; other site 515635002818 catalytic site [active] 515635002819 NAD binding site [chemical binding]; other site 515635002820 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 515635002821 heat shock protein HtpX; Provisional; Region: PRK04897 515635002822 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 515635002823 FMN binding site [chemical binding]; other site 515635002824 dimer interface [polypeptide binding]; other site 515635002825 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 515635002826 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 515635002827 active site 515635002828 nucleophile elbow; other site 515635002829 DRTGG domain; Region: DRTGG; pfam07085 515635002830 FOG: CBS domain [General function prediction only]; Region: COG0517 515635002831 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 515635002832 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 515635002833 ATP binding site [chemical binding]; other site 515635002834 Mg2+ binding site [ion binding]; other site 515635002835 G-X-G motif; other site 515635002836 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 515635002837 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 515635002838 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 515635002839 Putative Fe-S cluster; Region: FeS; cl17515 515635002840 DRTGG domain; Region: DRTGG; pfam07085 515635002841 DRTGG domain; Region: DRTGG; pfam07085 515635002842 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 515635002843 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432 515635002844 active site 515635002845 Thioredoxin-like [2Fe-2S] ferredoxin; Region: 2Fe-2S_thioredx; pfam01257 515635002846 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 515635002847 putative dimer interface [polypeptide binding]; other site 515635002848 [2Fe-2S] cluster binding site [ion binding]; other site 515635002849 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 515635002850 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 515635002851 ATP binding site [chemical binding]; other site 515635002852 Mg2+ binding site [ion binding]; other site 515635002853 G-X-G motif; other site 515635002854 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 515635002855 dimer interface [polypeptide binding]; other site 515635002856 [2Fe-2S] cluster binding site [ion binding]; other site 515635002857 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 515635002858 dimer interface [polypeptide binding]; other site 515635002859 [2Fe-2S] cluster binding site [ion binding]; other site 515635002860 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 515635002861 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 515635002862 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 515635002863 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 515635002864 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 515635002865 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 515635002866 N- and C-terminal domain interface [polypeptide binding]; other site 515635002867 D-xylulose kinase; Region: XylB; TIGR01312 515635002868 active site 515635002869 MgATP binding site [chemical binding]; other site 515635002870 catalytic site [active] 515635002871 metal binding site [ion binding]; metal-binding site 515635002872 xylulose binding site [chemical binding]; other site 515635002873 homodimer interface [polypeptide binding]; other site 515635002874 S-adenosylmethionine synthetase; Provisional; Region: PRK04439 515635002875 lysyl-tRNA synthetase; Reviewed; Region: lysK; PRK00750 515635002876 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 515635002877 active site 515635002878 nucleotide binding site [chemical binding]; other site 515635002879 HIGH motif; other site 515635002880 KMSKS motif; other site 515635002881 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 515635002882 active site 515635002883 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl18962 515635002884 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 515635002885 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 515635002886 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 515635002887 putative ADP-binding pocket [chemical binding]; other site 515635002888 Zinc dependent phospholipase C/S1-P1 nuclease; Region: ZnPC_S1P1; cl16915 515635002889 Zn binding site [ion binding]; other site 515635002890 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 515635002891 Purine nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pnp; COG0005 515635002892 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 515635002893 N-ethylammeline chlorohydrolase; Provisional; Region: PRK06038 515635002894 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 515635002895 active site 515635002896 putative substrate binding pocket [chemical binding]; other site 515635002897 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 515635002898 Asp_Lys_Asn_RS_N: N-terminal, anticodon recognition domain of class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop. Class 2b aaRSs include the homodimeric aspartyl-; Region: Asp_Lys_Asn_RS_N; cl19106 515635002899 Dimer interface [polypeptide binding]; other site 515635002900 anticodon binding site; other site 515635002901 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 515635002902 homodimer interface [polypeptide binding]; other site 515635002903 motif 1; other site 515635002904 motif 2; other site 515635002905 active site 515635002906 motif 3; other site 515635002907 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 515635002908 Receptor family ligand binding region; Region: ANF_receptor; pfam01094 515635002909 putative ligand binding site [chemical binding]; other site 515635002910 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 515635002911 TM-ABC transporter signature motif; other site 515635002912 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 515635002913 TM-ABC transporter signature motif; other site 515635002914 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 515635002915 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 515635002916 Walker A/P-loop; other site 515635002917 ATP binding site [chemical binding]; other site 515635002918 Q-loop/lid; other site 515635002919 ABC transporter signature motif; other site 515635002920 Walker B; other site 515635002921 D-loop; other site 515635002922 H-loop/switch region; other site 515635002923 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 515635002924 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 515635002925 Walker A/P-loop; other site 515635002926 ATP binding site [chemical binding]; other site 515635002927 Q-loop/lid; other site 515635002928 ABC transporter signature motif; other site 515635002929 Walker B; other site 515635002930 D-loop; other site 515635002931 H-loop/switch region; other site 515635002932 FOG: CBS domain [General function prediction only]; Region: COG0517 515635002933 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc2; cd04585 515635002934 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 515635002935 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 515635002936 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 515635002937 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 515635002938 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 515635002939 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 515635002940 dimer interface [polypeptide binding]; other site 515635002941 active site 515635002942 CoA binding pocket [chemical binding]; other site 515635002943 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 515635002944 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 515635002945 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 515635002946 NAD(P) binding site [chemical binding]; other site 515635002947 homotetramer interface [polypeptide binding]; other site 515635002948 homodimer interface [polypeptide binding]; other site 515635002949 active site 515635002950 acyl carrier protein; Provisional; Region: acpP; PRK00982 515635002951 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 515635002952 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 515635002953 dimer interface [polypeptide binding]; other site 515635002954 active site 515635002955 ribonuclease III; Reviewed; Region: rnc; PRK00102 515635002956 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 515635002957 dimerization interface [polypeptide binding]; other site 515635002958 active site 515635002959 metal binding site [ion binding]; metal-binding site 515635002960 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 515635002961 dsRNA binding site [nucleotide binding]; other site 515635002962 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 515635002963 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 515635002964 Walker A/P-loop; other site 515635002965 ATP binding site [chemical binding]; other site 515635002966 Q-loop/lid; other site 515635002967 Dynein heavy chain, N-terminal region 1; Region: DHC_N1; pfam08385 515635002968 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 515635002969 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 515635002970 ABC transporter signature motif; other site 515635002971 Walker B; other site 515635002972 D-loop; other site 515635002973 H-loop/switch region; other site 515635002974 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 515635002975 SRP54-type protein, GTPase domain; Region: SRP54; smart00962 515635002976 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 515635002977 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 515635002978 Coenzyme A binding pocket [chemical binding]; other site 515635002979 Signal peptidase (SPase) II; Region: Peptidase_A8; pfam01252 515635002980 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 515635002981 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 515635002982 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 515635002983 ATP-grasp domain; Region: ATP-grasp_4; cl17255 515635002984 photosystem II S4 domain protein; Region: PS_II_S4; TIGR03069 515635002985 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 515635002986 RNA binding surface [nucleotide binding]; other site 515635002987 Ribosomal protein L11 methylase [Translation, ribosomal structure and biogenesis]; Region: PrmA; COG2264 515635002988 DNA methylase; Region: N6_N4_Mtase; cl17433 515635002989 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 515635002990 S-adenosylmethionine binding site [chemical binding]; other site 515635002991 Arginase-like and histone-like hydrolases; Region: Arginase_HDAC; cl17011 515635002992 active site 515635002993 metal binding site [ion binding]; metal-binding site 515635002994 chaperonin GroEL; Reviewed; Region: groEL; PRK12850 515635002995 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 515635002996 ring oligomerisation interface [polypeptide binding]; other site 515635002997 ATP/Mg binding site [chemical binding]; other site 515635002998 stacking interactions; other site 515635002999 hinge regions; other site 515635003000 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 515635003001 oligomerisation interface [polypeptide binding]; other site 515635003002 mobile loop; other site 515635003003 roof hairpin; other site 515635003004 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 515635003005 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 515635003006 putative ADP-binding pocket [chemical binding]; other site 515635003007 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 515635003008 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 515635003009 Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219 515635003010 UGMP family protein; Validated; Region: PRK09604 515635003011 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 515635003012 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 515635003013 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 515635003014 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 515635003015 Coenzyme A binding pocket [chemical binding]; other site 515635003016 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 515635003017 Glycoprotease family; Region: Peptidase_M22; pfam00814 515635003018 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 515635003019 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 515635003020 GDP-binding site [chemical binding]; other site 515635003021 ACT binding site; other site 515635003022 IMP binding site; other site 515635003023 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 515635003024 Malic enzyme, N-terminal domain; Region: malic; pfam00390 515635003025 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 515635003026 putative NAD(P) binding site [chemical binding]; other site 515635003027 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 515635003028 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 515635003029 dimer interface [polypeptide binding]; other site 515635003030 anticodon binding site; other site 515635003031 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 515635003032 homodimer interface [polypeptide binding]; other site 515635003033 motif 1; other site 515635003034 active site 515635003035 motif 2; other site 515635003036 GAD domain; Region: GAD; pfam02938 515635003037 motif 3; other site 515635003038 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 515635003039 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 515635003040 dimer interface [polypeptide binding]; other site 515635003041 motif 1; other site 515635003042 active site 515635003043 motif 2; other site 515635003044 motif 3; other site 515635003045 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 515635003046 anticodon binding site; other site 515635003047 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 515635003048 putative active site [active] 515635003049 dimerization interface [polypeptide binding]; other site 515635003050 putative tRNAtyr binding site [nucleotide binding]; other site 515635003051 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 515635003052 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 515635003053 Zn2+ binding site [ion binding]; other site 515635003054 Mg2+ binding site [ion binding]; other site 515635003055 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 515635003056 synthetase active site [active] 515635003057 NTP binding site [chemical binding]; other site 515635003058 metal binding site [ion binding]; metal-binding site 515635003059 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 515635003060 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 515635003061 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 515635003062 Major Facilitator Superfamily; Region: MFS_1; pfam07690 515635003063 putative substrate translocation pore; other site 515635003064 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 515635003065 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 515635003066 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 515635003067 RPB12 interaction site [polypeptide binding]; other site 515635003068 RPB1 interaction site [polypeptide binding]; other site 515635003069 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 515635003070 RPB10 interaction site [polypeptide binding]; other site 515635003071 RPB11 interaction site [polypeptide binding]; other site 515635003072 RPB3 interaction site [polypeptide binding]; other site 515635003073 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 515635003074 Largest subunit (beta') of bacterial DNA-dependent RNA polymerase (RNAP), N-terminal domain; Region: RNAP_beta'_N; cd01609 515635003075 beta and beta' interface [polypeptide binding]; other site 515635003076 beta' and sigma factor interface [polypeptide binding]; other site 515635003077 Zn-binding [ion binding]; other site 515635003078 active site region [active] 515635003079 catalytic site [active] 515635003080 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 515635003081 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 515635003082 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 515635003083 DNA binding site [nucleotide binding] 515635003084 Apocytochrome F, C-terminal; Region: Apocytochr_F_C; cl03168 515635003085 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 515635003086 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 515635003087 S17 interaction site [polypeptide binding]; other site 515635003088 S8 interaction site; other site 515635003089 16S rRNA interaction site [nucleotide binding]; other site 515635003090 streptomycin interaction site [chemical binding]; other site 515635003091 23S rRNA interaction site [nucleotide binding]; other site 515635003092 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 515635003093 30S ribosomal protein S7; Validated; Region: PRK05302 515635003094 elongation factor G; Reviewed; Region: PRK00007 515635003095 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 515635003096 G1 box; other site 515635003097 putative GEF interaction site [polypeptide binding]; other site 515635003098 GTP/Mg2+ binding site [chemical binding]; other site 515635003099 Switch I region; other site 515635003100 G2 box; other site 515635003101 G3 box; other site 515635003102 Switch II region; other site 515635003103 G4 box; other site 515635003104 G5 box; other site 515635003105 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 515635003106 Elongation Factor G, domain II; Region: EFG_II; pfam14492 515635003107 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 515635003108 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 515635003109 elongation factor Tu; Reviewed; Region: PRK00049 515635003110 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 515635003111 G1 box; other site 515635003112 GEF interaction site [polypeptide binding]; other site 515635003113 GTP/Mg2+ binding site [chemical binding]; other site 515635003114 Switch I region; other site 515635003115 G2 box; other site 515635003116 G3 box; other site 515635003117 Switch II region; other site 515635003118 G4 box; other site 515635003119 G5 box; other site 515635003120 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 515635003121 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 515635003122 Antibiotic Binding Site [chemical binding]; other site 515635003123 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 515635003124 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 515635003125 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 515635003126 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 515635003127 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 515635003128 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 515635003129 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 515635003130 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 515635003131 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 515635003132 putative translocon binding site; other site 515635003133 protein-rRNA interface [nucleotide binding]; other site 515635003134 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 515635003135 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 515635003136 G-X-X-G motif; other site 515635003137 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 515635003138 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 515635003139 23S rRNA interface [nucleotide binding]; other site 515635003140 5S rRNA interface [nucleotide binding]; other site 515635003141 putative antibiotic binding site [chemical binding]; other site 515635003142 L25 interface [polypeptide binding]; other site 515635003143 L27 interface [polypeptide binding]; other site 515635003144 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 515635003145 23S rRNA interface [nucleotide binding]; other site 515635003146 putative translocon interaction site; other site 515635003147 signal recognition particle (SRP54) interaction site; other site 515635003148 L23 interface [polypeptide binding]; other site 515635003149 trigger factor interaction site; other site 515635003150 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 515635003151 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 515635003152 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 515635003153 RNA binding site [nucleotide binding]; other site 515635003154 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 515635003155 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 515635003156 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 515635003157 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 515635003158 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 515635003159 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 515635003160 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 515635003161 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 515635003162 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 515635003163 5S rRNA interface [nucleotide binding]; other site 515635003164 L27 interface [polypeptide binding]; other site 515635003165 23S rRNA interface [nucleotide binding]; other site 515635003166 L5 interface [polypeptide binding]; other site 515635003167 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 515635003168 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 515635003169 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 515635003170 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 515635003171 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 515635003172 SecY translocase; Region: SecY; pfam00344 515635003173 adenylate kinase; Reviewed; Region: adk; PRK00279 515635003174 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 515635003175 AMP-binding site [chemical binding]; other site 515635003176 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 515635003177 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 515635003178 active site 515635003179 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 515635003180 rRNA binding site [nucleotide binding]; other site 515635003181 predicted 30S ribosome binding site; other site 515635003182 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 515635003183 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 515635003184 30S ribosomal protein S11; Validated; Region: PRK05309 515635003185 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 515635003186 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 515635003187 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 515635003188 RNA binding surface [nucleotide binding]; other site 515635003189 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 515635003190 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 515635003191 alphaNTD homodimer interface [polypeptide binding]; other site 515635003192 alphaNTD - beta interaction site [polypeptide binding]; other site 515635003193 alphaNTD - beta' interaction site [polypeptide binding]; other site 515635003194 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 515635003195 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 515635003196 cobalt transporter ATP-binding subunit; Provisional; Region: PRK13633 515635003197 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 515635003198 Walker A/P-loop; other site 515635003199 ATP binding site [chemical binding]; other site 515635003200 Q-loop/lid; other site 515635003201 ABC transporter signature motif; other site 515635003202 Walker B; other site 515635003203 D-loop; other site 515635003204 H-loop/switch region; other site 515635003205 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13637 515635003206 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 515635003207 Walker A/P-loop; other site 515635003208 ATP binding site [chemical binding]; other site 515635003209 Q-loop/lid; other site 515635003210 ABC transporter signature motif; other site 515635003211 Walker B; other site 515635003212 D-loop; other site 515635003213 H-loop/switch region; other site 515635003214 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 515635003215 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 515635003216 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 515635003217 dimerization interface 3.5A [polypeptide binding]; other site 515635003218 active site 515635003219 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 515635003220 23S rRNA interface [nucleotide binding]; other site 515635003221 L3 interface [polypeptide binding]; other site 515635003222 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 515635003223 AMMECR1; Region: AMMECR1; pfam01871 515635003224 Pyruvate-formate lyase-activating enzyme [Posttranslational modification, protein turnover, chaperones]; Region: PflA; COG1180 515635003225 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 515635003226 FeS/SAM binding site; other site 515635003227 Predicted Zn-ribbon RNA-binding protein with a function in translation [Translation, ribosomal structure and biogenesis]; Region: COG2888; cl19729 515635003228 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 515635003229 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 515635003230 active site 515635003231 substrate binding site [chemical binding]; other site 515635003232 metal binding site [ion binding]; metal-binding site 515635003233 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 515635003234 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 515635003235 glutaminase active site [active] 515635003236 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 515635003237 dimer interface [polypeptide binding]; other site 515635003238 active site 515635003239 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 515635003240 dimer interface [polypeptide binding]; other site 515635003241 active site 515635003242 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 515635003243 TPR repeat; Region: TPR_11; pfam13414 515635003244 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 515635003245 binding surface 515635003246 TPR motif; other site 515635003247 Tetratricopeptide repeat; Region: TPR_16; pfam13432 515635003248 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 515635003249 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 515635003250 motif 1; other site 515635003251 active site 515635003252 motif 2; other site 515635003253 motif 3; other site 515635003254 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 515635003255 DHHA1 domain; Region: DHHA1; pfam02272 515635003256 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 515635003257 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 515635003258 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 515635003259 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 515635003260 active site 515635003261 dimer interface [polypeptide binding]; other site 515635003262 motif 1; other site 515635003263 motif 2; other site 515635003264 motif 3; other site 515635003265 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 515635003266 anticodon binding site; other site 515635003267 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 515635003268 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 515635003269 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 515635003270 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 515635003271 Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimT; COG4970 515635003272 PilX N-terminal; Region: PilX_N; pfam14341 515635003273 Protein of unknown function (DUF342); Region: DUF342; cl19219 515635003274 Type IV pilus assembly protein PilM; Region: PilM_2; pfam11104 515635003275 Fimbrial assembly protein (PilN); Region: PilN; cl19830 515635003276 Pilus assembly protein, PilO; Region: PilO; cl01234 515635003277 Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356 515635003278 AMIN domain; Region: AMIN; pfam11741 515635003279 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 515635003280 type II secretion system protein D; Region: type_II_gspD; TIGR02517 515635003281 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 515635003282 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 515635003283 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 515635003284 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 515635003285 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 515635003286 active site 515635003287 elongation factor P; Validated; Region: PRK00529 515635003288 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 515635003289 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 515635003290 RNA binding site [nucleotide binding]; other site 515635003291 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 515635003292 RNA binding site [nucleotide binding]; other site 515635003293 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 515635003294 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 515635003295 carboxyltransferase (CT) interaction site; other site 515635003296 biotinylation site [posttranslational modification]; other site 515635003297 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 515635003298 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 515635003299 ATP-grasp domain; Region: ATP-grasp_4; cl17255 515635003300 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 515635003301 Asp23 family; Region: Asp23; pfam03780 515635003302 transcription antitermination factor NusB; Region: nusB; TIGR01951 515635003303 putative RNA binding site [nucleotide binding]; other site 515635003304 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 515635003305 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 515635003306 TPP-binding site; other site 515635003307 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 515635003308 PYR/PP interface [polypeptide binding]; other site 515635003309 dimer interface [polypeptide binding]; other site 515635003310 TPP binding site [chemical binding]; other site 515635003311 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 515635003312 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 515635003313 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 515635003314 RNA binding surface [nucleotide binding]; other site 515635003315 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 515635003316 NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061 515635003317 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 515635003318 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 515635003319 Walker A/P-loop; other site 515635003320 ATP binding site [chemical binding]; other site 515635003321 Q-loop/lid; other site 515635003322 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 515635003323 ABC transporter signature motif; other site 515635003324 Walker B; other site 515635003325 D-loop; other site 515635003326 H-loop/switch region; other site 515635003327 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 515635003328 dimer interface [polypeptide binding]; other site 515635003329 ADP-ribose binding site [chemical binding]; other site 515635003330 active site 515635003331 nudix motif; other site 515635003332 metal binding site [ion binding]; metal-binding site 515635003333 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 515635003334 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 515635003335 hexamer interface [polypeptide binding]; other site 515635003336 ligand binding site [chemical binding]; other site 515635003337 putative active site [active] 515635003338 NAD(P) binding site [chemical binding]; other site 515635003339 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 515635003340 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 515635003341 dimerization interface [polypeptide binding]; other site 515635003342 domain crossover interface; other site 515635003343 redox-dependent activation switch; other site 515635003344 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 515635003345 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 515635003346 substrate binding pocket [chemical binding]; other site 515635003347 membrane-bound complex binding site; other site 515635003348 hinge residues; other site 515635003349 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 515635003350 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 515635003351 dimer interface [polypeptide binding]; other site 515635003352 conserved gate region; other site 515635003353 putative PBP binding loops; other site 515635003354 ABC-ATPase subunit interface; other site 515635003355 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 515635003356 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 515635003357 Walker A/P-loop; other site 515635003358 ATP binding site [chemical binding]; other site 515635003359 Q-loop/lid; other site 515635003360 ABC transporter signature motif; other site 515635003361 Walker B; other site 515635003362 D-loop; other site 515635003363 H-loop/switch region; other site 515635003364 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 515635003365 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 515635003366 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 515635003367 shikimate binding site; other site 515635003368 NAD(P) binding site [chemical binding]; other site 515635003369 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 515635003370 Tetramer interface [polypeptide binding]; other site 515635003371 active site 515635003372 FMN-binding site [chemical binding]; other site 515635003373 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 515635003374 active site 515635003375 dimer interface [polypeptide binding]; other site 515635003376 metal binding site [ion binding]; metal-binding site 515635003377 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 515635003378 DAHP synthetase I family; Region: DAHP_synth_1; cl17225 515635003379 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 515635003380 prephenate dehydrogenase; Validated; Region: PRK08507 515635003381 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 515635003382 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 515635003383 hinge; other site 515635003384 active site 515635003385 Trp repressor protein; Region: Trp_repressor; cl17266 515635003386 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 515635003387 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 515635003388 Walker A/P-loop; other site 515635003389 ATP binding site [chemical binding]; other site 515635003390 Q-loop/lid; other site 515635003391 ABC transporter signature motif; other site 515635003392 Walker B; other site 515635003393 D-loop; other site 515635003394 H-loop/switch region; other site 515635003395 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 515635003396 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 515635003397 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 515635003398 Walker A/P-loop; other site 515635003399 ATP binding site [chemical binding]; other site 515635003400 Q-loop/lid; other site 515635003401 ABC transporter signature motif; other site 515635003402 Walker B; other site 515635003403 D-loop; other site 515635003404 H-loop/switch region; other site 515635003405 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 515635003406 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 515635003407 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 515635003408 dimer interface [polypeptide binding]; other site 515635003409 conserved gate region; other site 515635003410 putative PBP binding loops; other site 515635003411 ABC-ATPase subunit interface; other site 515635003412 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 515635003413 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 515635003414 dimer interface [polypeptide binding]; other site 515635003415 conserved gate region; other site 515635003416 putative PBP binding loops; other site 515635003417 ABC-ATPase subunit interface; other site 515635003418 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 515635003419 Predicted solute binding protein [General function prediction only]; Region: COG3889 515635003420 ferredoxin-NADP(+) reductase subunit alpha; Reviewed; Region: PRK06222 515635003421 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)...; Region: DHOD_e_trans_like1; cd06219 515635003422 FAD binding pocket [chemical binding]; other site 515635003423 FAD binding motif [chemical binding]; other site 515635003424 phosphate binding motif [ion binding]; other site 515635003425 beta-alpha-beta structure motif; other site 515635003426 NAD binding pocket [chemical binding]; other site 515635003427 Iron coordination center [ion binding]; other site 515635003428 putative oxidoreductase; Provisional; Region: PRK12831 515635003429 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster; Region: Fer4_20; pfam14691 515635003430 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 515635003431 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 515635003432 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 515635003433 putative homodimer interface [polypeptide binding]; other site 515635003434 putative homotetramer interface [polypeptide binding]; other site 515635003435 putative allosteric switch controlling residues; other site 515635003436 putative metal binding site [ion binding]; other site 515635003437 putative homodimer-homodimer interface [polypeptide binding]; other site 515635003438 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 515635003439 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 515635003440 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 515635003441 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 515635003442 active site 515635003443 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 515635003444 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 515635003445 metal binding site 2 [ion binding]; metal-binding site 515635003446 putative DNA binding helix; other site 515635003447 metal binding site 1 [ion binding]; metal-binding site 515635003448 dimer interface [polypeptide binding]; other site 515635003449 structural Zn2+ binding site [ion binding]; other site 515635003450 Arginine repressor [Transcription]; Region: ArgR; COG1438 515635003451 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 515635003452 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 515635003453 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 515635003454 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 515635003455 Histidine kinase; Region: HisKA_2; pfam07568 515635003456 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 515635003457 ATP binding site [chemical binding]; other site 515635003458 Mg2+ binding site [ion binding]; other site 515635003459 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14328 515635003460 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 515635003461 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 515635003462 FeS/SAM binding site; other site 515635003463 TRAM domain; Region: TRAM; pfam01938 515635003464 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 515635003465 MutS domain I; Region: MutS_I; pfam01624 515635003466 MutS domain II; Region: MutS_II; pfam05188 515635003467 MutS domain III; Region: MutS_III; pfam05192 515635003468 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 515635003469 Walker A/P-loop; other site 515635003470 ATP binding site [chemical binding]; other site 515635003471 Q-loop/lid; other site 515635003472 ABC transporter signature motif; other site 515635003473 Walker B; other site 515635003474 D-loop; other site 515635003475 H-loop/switch region; other site 515635003476 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 515635003477 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 515635003478 ATP binding site [chemical binding]; other site 515635003479 Mg2+ binding site [ion binding]; other site 515635003480 G-X-G motif; other site 515635003481 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 515635003482 ATP binding site [chemical binding]; other site 515635003483 MutL C terminal dimerisation domain; Region: MutL_C; smart00853 515635003484 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 515635003485 LL-diaminopimelate aminotransferase; Region: DapC_direct; TIGR03540 515635003486 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 515635003487 pyridoxal 5'-phosphate binding site [chemical binding]; other site 515635003488 homodimer interface [polypeptide binding]; other site 515635003489 catalytic residue [active] 515635003490 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 515635003491 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 515635003492 HflX GTPase family; Region: HflX; cd01878 515635003493 G1 box; other site 515635003494 GTP/Mg2+ binding site [chemical binding]; other site 515635003495 Switch I region; other site 515635003496 G2 box; other site 515635003497 G3 box; other site 515635003498 Switch II region; other site 515635003499 G4 box; other site 515635003500 G5 box; other site 515635003501 Uncharacterized conserved protein [Function unknown]; Region: COG1801 515635003502 transcription termination factor Rho; Provisional; Region: rho; PRK09376 515635003503 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 515635003504 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 515635003505 RNA binding site [nucleotide binding]; other site 515635003506 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 515635003507 Walker A motif; other site 515635003508 ATP binding site [chemical binding]; other site 515635003509 Walker B motif; other site 515635003510 Sporulation and spore germination; Region: Germane; pfam10646 515635003511 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 515635003512 active site 515635003513 metal binding site [ion binding]; metal-binding site 515635003514 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 515635003515 active site 515635003516 metal binding site [ion binding]; metal-binding site 515635003517 homotetramer interface [polypeptide binding]; other site 515635003518 Bacterial trigger factor protein (TF); Region: Trigger_N; pfam05697 515635003519 trigger factor; Region: tig; TIGR00115 515635003520 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 515635003521 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 515635003522 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 515635003523 oligomer interface [polypeptide binding]; other site 515635003524 active site residues [active] 515635003525 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 515635003526 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 515635003527 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 515635003528 Walker A motif; other site 515635003529 ATP binding site [chemical binding]; other site 515635003530 Walker B motif; other site 515635003531 GGDN family; Region: GGDN; cl19424 515635003532 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 515635003533 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 515635003534 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 515635003535 active site 515635003536 HIGH motif; other site 515635003537 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 515635003538 KMSKS motif; other site 515635003539 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 515635003540 tRNA binding surface [nucleotide binding]; other site 515635003541 anticodon binding site; other site 515635003542 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 515635003543 electron transport complex, RnfABCDGE type, C subunit; Region: rnfC; TIGR01945 515635003544 RnfC Barrel sandwich hybrid domain; Region: RnfC_N; pfam13375 515635003545 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 515635003546 SLBB domain; Region: SLBB; pfam10531 515635003547 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 515635003548 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; pfam03116 515635003549 FMN-binding domain; Region: FMN_bind; cl01081 515635003550 Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597 515635003551 Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597 515635003552 ferredoxin; Validated; Region: PRK07118 515635003553 Putative Fe-S cluster; Region: FeS; cl17515 515635003554 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 515635003555 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 515635003556 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 515635003557 Heptaprenyl diphosphate synthase component I; Region: Hpre_diP_synt_I; pfam07456 515635003558 Domain of unknown function (DUF4321); Region: DUF4321; pfam14209 515635003559 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 515635003560 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 515635003561 Peptidase family M23; Region: Peptidase_M23; pfam01551 515635003562 C-terminal peptidase (prc); Region: prc; TIGR00225 515635003563 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 515635003564 protein binding site [polypeptide binding]; other site 515635003565 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 515635003566 Catalytic dyad [active] 515635003567 SLBB domain; Region: SLBB; pfam10531 515635003568 comEA protein; Region: comE; TIGR01259 515635003569 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 515635003570 Competence protein; Region: Competence; pfam03772 515635003571 DNA polymerase III, delta subunit [DNA replication, recombination, and repair]; Region: HolA; COG1466 515635003572 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; cl19912 515635003573 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 515635003574 GTP-binding protein LepA; Provisional; Region: PRK05433 515635003575 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 515635003576 G1 box; other site 515635003577 putative GEF interaction site [polypeptide binding]; other site 515635003578 GTP/Mg2+ binding site [chemical binding]; other site 515635003579 Switch I region; other site 515635003580 G2 box; other site 515635003581 G3 box; other site 515635003582 Switch II region; other site 515635003583 G4 box; other site 515635003584 G5 box; other site 515635003585 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 515635003586 Elongation Factor G, domain II; Region: EFG_II; pfam14492 515635003587 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 515635003588 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 515635003589 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 515635003590 Coproporphyrinogen III oxidase and related Fe-S oxidoreductases [Coenzyme metabolism]; Region: HemN; COG0635 515635003591 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 515635003592 FeS/SAM binding site; other site 515635003593 HemN C-terminal domain; Region: HemN_C; pfam06969 515635003594 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 515635003595 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 515635003596 active site 515635003597 phosphorylation site [posttranslational modification] 515635003598 intermolecular recognition site; other site 515635003599 dimerization interface [polypeptide binding]; other site 515635003600 ANTAR domain; Region: ANTAR; pfam03861 515635003601 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 515635003602 Mg++ binding site [ion binding]; other site 515635003603 putative catalytic motif [active] 515635003604 substrate binding site [chemical binding]; other site 515635003605 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 515635003606 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 515635003607 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 515635003608 Methyltransferase domain; Region: Methyltransf_31; pfam13847 515635003609 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 515635003610 S-adenosylmethionine binding site [chemical binding]; other site 515635003611 Zinc ribbon domain; Region: Zn-ribbon_8; cl00993 515635003612 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 515635003613 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 515635003614 nucleotide binding site [chemical binding]; other site 515635003615 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 515635003616 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 515635003617 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 515635003618 Histidyl-tRNA synthetase; Region: tRNA-synt_His; pfam13393 515635003619 motif 1; other site 515635003620 dimer interface [polypeptide binding]; other site 515635003621 active site 515635003622 motif 2; other site 515635003623 motif 3; other site 515635003624 ATP phosphoribosyltransferase; Region: HisG; cl15266 515635003625 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 515635003626 histidinol dehydrogenase; Region: hisD; TIGR00069 515635003627 NAD binding site [chemical binding]; other site 515635003628 dimerization interface [polypeptide binding]; other site 515635003629 product binding site; other site 515635003630 substrate binding site [chemical binding]; other site 515635003631 zinc binding site [ion binding]; other site 515635003632 catalytic residues [active] 515635003633 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 515635003634 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 515635003635 pyridoxal 5'-phosphate binding site [chemical binding]; other site 515635003636 homodimer interface [polypeptide binding]; other site 515635003637 catalytic residue [active] 515635003638 imidazoleglycerol-phosphate dehydratase; Validated; Region: hisB; PRK00951 515635003639 putative active site pocket [active] 515635003640 4-fold oligomerization interface [polypeptide binding]; other site 515635003641 metal binding residues [ion binding]; metal-binding site 515635003642 3-fold/trimer interface [polypeptide binding]; other site 515635003643 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13142 515635003644 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 515635003645 putative active site [active] 515635003646 oxyanion strand; other site 515635003647 catalytic triad [active] 515635003648 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 515635003649 catalytic residues [active] 515635003650 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 515635003651 substrate binding site [chemical binding]; other site 515635003652 glutamase interaction surface [polypeptide binding]; other site 515635003653 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 515635003654 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 515635003655 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 515635003656 metal binding site [ion binding]; metal-binding site 515635003657 Transglycosylase; Region: Transgly; pfam00912 515635003658 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 515635003659 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 515635003660 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 515635003661 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 515635003662 phosphate binding site [ion binding]; other site 515635003663 putative substrate binding pocket [chemical binding]; other site 515635003664 dimer interface [polypeptide binding]; other site 515635003665 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 515635003666 substrate binding site [chemical binding]; other site 515635003667 hinge regions; other site 515635003668 ADP binding site [chemical binding]; other site 515635003669 catalytic site [active] 515635003670 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 515635003671 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 515635003672 substrate binding site [chemical binding]; other site 515635003673 dimer interface [polypeptide binding]; other site 515635003674 catalytic triad [active] 515635003675 preprotein translocase subunit SecG; Reviewed; Region: secG; PRK06870 515635003676 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 515635003677 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 515635003678 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 515635003679 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 515635003680 dimer interface [polypeptide binding]; other site 515635003681 conserved gate region; other site 515635003682 putative PBP binding loops; other site 515635003683 ABC-ATPase subunit interface; other site 515635003684 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 515635003685 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 515635003686 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 515635003687 dimer interface [polypeptide binding]; other site 515635003688 conserved gate region; other site 515635003689 putative PBP binding loops; other site 515635003690 ABC-ATPase subunit interface; other site 515635003691 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 515635003692 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 515635003693 DAK2 domain; Region: Dak2; pfam02734 515635003694 Dihydroxyacetone kinase family; Region: Dak1_2; pfam13684 515635003695 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 515635003696 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 515635003697 ssDNA binding site; other site 515635003698 generic binding surface II; other site 515635003699 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 515635003700 ATP binding site [chemical binding]; other site 515635003701 putative Mg++ binding site [ion binding]; other site 515635003702 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 515635003703 nucleotide binding region [chemical binding]; other site 515635003704 ATP-binding site [chemical binding]; other site 515635003705 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 515635003706 S-adenosylmethionine binding site [chemical binding]; other site 515635003707 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 515635003708 active site 515635003709 (T/H)XGH motif; other site 515635003710 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 515635003711 16S/18S rRNA binding site [nucleotide binding]; other site 515635003712 S13e-L30e interaction site [polypeptide binding]; other site 515635003713 25S rRNA binding site [nucleotide binding]; other site 515635003714 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 515635003715 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 515635003716 RNase E interface [polypeptide binding]; other site 515635003717 trimer interface [polypeptide binding]; other site 515635003718 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 515635003719 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 515635003720 RNase E interface [polypeptide binding]; other site 515635003721 trimer interface [polypeptide binding]; other site 515635003722 active site 515635003723 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 515635003724 putative nucleic acid binding region [nucleotide binding]; other site 515635003725 G-X-X-G motif; other site 515635003726 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 515635003727 RNA binding site [nucleotide binding]; other site 515635003728 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 515635003729 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 515635003730 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 515635003731 dihydrodipicolinate reductase; Provisional; Region: PRK00048 515635003732 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 515635003733 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 515635003734 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 515635003735 dimer interface [polypeptide binding]; other site 515635003736 active site 515635003737 catalytic residue [active] 515635003738 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 515635003739 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 515635003740 RNA-metabolizing metallo-beta-lactamase; Region: RMMBL; pfam07521 515635003741 Rhodopsin-like GPCR transmembrane domain; Region: GpcrRhopsn4; pfam10192 515635003742 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 515635003743 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 515635003744 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 515635003745 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 515635003746 ligand binding site [chemical binding]; other site 515635003747 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 515635003748 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 515635003749 Walker A/P-loop; other site 515635003750 ATP binding site [chemical binding]; other site 515635003751 Q-loop/lid; other site 515635003752 ABC transporter signature motif; other site 515635003753 Walker B; other site 515635003754 D-loop; other site 515635003755 H-loop/switch region; other site 515635003756 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 515635003757 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 515635003758 TM-ABC transporter signature motif; other site 515635003759 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 515635003760 TM-ABC transporter signature motif; other site 515635003761 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 515635003762 putative acyl-acceptor binding pocket; other site 515635003763 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 515635003764 putative acyl-acceptor binding pocket; other site 515635003765 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Region: lytB_ispH; cd13944 515635003766 Fe-S cluster binding site [ion binding]; other site 515635003767 substrate binding site [chemical binding]; other site 515635003768 catalytic site [active] 515635003769 GTP-binding protein Der; Reviewed; Region: PRK00093 515635003770 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 515635003771 G1 box; other site 515635003772 GTP/Mg2+ binding site [chemical binding]; other site 515635003773 Switch I region; other site 515635003774 G2 box; other site 515635003775 Switch II region; other site 515635003776 G3 box; other site 515635003777 G4 box; other site 515635003778 G5 box; other site 515635003779 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 515635003780 G1 box; other site 515635003781 GTP/Mg2+ binding site [chemical binding]; other site 515635003782 Switch I region; other site 515635003783 G2 box; other site 515635003784 G3 box; other site 515635003785 Switch II region; other site 515635003786 G4 box; other site 515635003787 G5 box; other site 515635003788 KH-domain-like of EngA bacterial GTPase enzymes, C-terminal; Region: KH_dom-like; pfam14714 515635003789 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 515635003790 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 515635003791 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 515635003792 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 515635003793 recombinase A; Provisional; Region: recA; PRK09354 515635003794 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 515635003795 hexamer interface [polypeptide binding]; other site 515635003796 Walker A motif; other site 515635003797 ATP binding site [chemical binding]; other site 515635003798 Walker B motif; other site 515635003799 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 515635003800 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 515635003801 Walker A/P-loop; other site 515635003802 ATP binding site [chemical binding]; other site 515635003803 Q-loop/lid; other site 515635003804 ABC transporter signature motif; other site 515635003805 Walker B; other site 515635003806 D-loop; other site 515635003807 H-loop/switch region; other site 515635003808 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 515635003809 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 515635003810 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 515635003811 Walker A/P-loop; other site 515635003812 ATP binding site [chemical binding]; other site 515635003813 Q-loop/lid; other site 515635003814 ABC transporter signature motif; other site 515635003815 Walker B; other site 515635003816 D-loop; other site 515635003817 H-loop/switch region; other site 515635003818 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 515635003819 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 515635003820 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 515635003821 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 515635003822 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 515635003823 GatB domain; Region: GatB_Yqey; smart00845 515635003824 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 515635003825 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 515635003826 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 515635003827 Walker A motif; other site 515635003828 ATP binding site [chemical binding]; other site 515635003829 Walker B motif; other site 515635003830 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 515635003831 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 515635003832 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 515635003833 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 515635003834 Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimT; COG4970 515635003835 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 515635003836 Lamin Tail Domain; Region: LTD; pfam00932 515635003837 Lamin Tail Domain; Region: LTD; pfam00932 515635003838 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl19066 515635003839 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 515635003840 Pilus assembly protein, PilO; Region: PilO; cl01234 515635003841 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 515635003842 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 515635003843 acetolactate synthase 3 catalytic subunit; Reviewed; Region: PRK06048 515635003844 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 515635003845 PYR/PP interface [polypeptide binding]; other site 515635003846 dimer interface [polypeptide binding]; other site 515635003847 TPP binding site [chemical binding]; other site 515635003848 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 515635003849 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 515635003850 TPP-binding site [chemical binding]; other site 515635003851 dimer interface [polypeptide binding]; other site 515635003852 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 515635003853 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 515635003854 putative valine binding site [chemical binding]; other site 515635003855 dimer interface [polypeptide binding]; other site 515635003856 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 515635003857 ketol-acid reductoisomerase; Provisional; Region: PRK05479 515635003858 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 515635003859 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 515635003860 2-isopropylmalate synthase; Validated; Region: PRK00915 515635003861 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 515635003862 active site 515635003863 catalytic residues [active] 515635003864 metal binding site [ion binding]; metal-binding site 515635003865 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 515635003866 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 515635003867 substrate binding site [chemical binding]; other site 515635003868 ligand binding site [chemical binding]; other site 515635003869 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 515635003870 substrate binding site [chemical binding]; other site 515635003871 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 515635003872 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 515635003873 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 515635003874 active site 515635003875 catalytic residues [active] 515635003876 metal binding site [ion binding]; metal-binding site 515635003877 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 515635003878 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 515635003879 galactokinase; Provisional; Region: PRK03817 515635003880 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 515635003881 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 515635003882 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 515635003883 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 515635003884 dimer interface [polypeptide binding]; other site 515635003885 active site 515635003886 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 515635003887 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 515635003888 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 515635003889 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 515635003890 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 515635003891 Cis (Z)-Isoprenyl Diphosphate Synthases; Region: Cis_IPPS; cd00475 515635003892 active site 515635003893 dimer interface [polypeptide binding]; other site 515635003894 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 515635003895 hinge region; other site 515635003896 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 515635003897 putative nucleotide binding site [chemical binding]; other site 515635003898 uridine monophosphate binding site [chemical binding]; other site 515635003899 homohexameric interface [polypeptide binding]; other site 515635003900 elongation factor Ts; Reviewed; Region: tsf; PRK12332 515635003901 UBA/TS-N domain; Region: UBA; pfam00627 515635003902 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 515635003903 rRNA interaction site [nucleotide binding]; other site 515635003904 S8 interaction site; other site 515635003905 putative laminin-1 binding site; other site 515635003906 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 515635003907 putative oligomer interface [polypeptide binding]; other site 515635003908 putative RNA binding site [nucleotide binding]; other site 515635003909 NusA N-terminal domain; Region: NusA_N; pfam08529 515635003910 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 515635003911 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 515635003912 RNA binding site [nucleotide binding]; other site 515635003913 homodimer interface [polypeptide binding]; other site 515635003914 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 515635003915 G-X-X-G motif; other site 515635003916 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 515635003917 G-X-X-G motif; other site 515635003918 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 515635003919 putative RNA binding cleft [nucleotide binding]; other site 515635003920 translation initiation factor IF-2; Validated; Region: infB; PRK05306 515635003921 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 515635003922 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 515635003923 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 515635003924 G1 box; other site 515635003925 putative GEF interaction site [polypeptide binding]; other site 515635003926 GTP/Mg2+ binding site [chemical binding]; other site 515635003927 Switch I region; other site 515635003928 G2 box; other site 515635003929 G3 box; other site 515635003930 Switch II region; other site 515635003931 G4 box; other site 515635003932 G5 box; other site 515635003933 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 515635003934 Translation-initiation factor 2; Region: IF-2; pfam11987 515635003935 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 515635003936 Protein of unknown function (DUF503); Region: DUF503; pfam04456 515635003937 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 515635003938 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 515635003939 DHH family; Region: DHH; pfam01368 515635003940 DHHA1 domain; Region: DHHA1; pfam02272 515635003941 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK00130 515635003942 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 515635003943 RNA binding site [nucleotide binding]; other site 515635003944 active site 515635003945 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 515635003946 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 515635003947 active site 515635003948 Riboflavin kinase; Region: Flavokinase; pfam01687 515635003949 cytidylate kinase; Provisional; Region: cmk; PRK00023 515635003950 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 515635003951 CMP-binding site; other site 515635003952 The sites determining sugar specificity; other site 515635003953 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 515635003954 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 515635003955 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 515635003956 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 515635003957 active site 515635003958 motif I; other site 515635003959 motif II; other site 515635003960 Protein of unknown function (DUF3307); Region: DUF3307; pfam11750 515635003961 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 515635003962 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 515635003963 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 515635003964 Zn2+ binding site [ion binding]; other site 515635003965 Mg2+ binding site [ion binding]; other site 515635003966 CHASE2 domain; Region: CHASE2; pfam05226 515635003967 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 515635003968 cyclase homology domain; Region: CHD; cd07302 515635003969 nucleotidyl binding site; other site 515635003970 metal binding site [ion binding]; metal-binding site 515635003971 dimer interface [polypeptide binding]; other site 515635003972 FecR protein; Region: FecR; pfam04773 515635003973 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 515635003974 nucleotide binding site [chemical binding]; other site 515635003975 Type III pantothenate kinase; Region: Pan_kinase; cl17198 515635003976 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 515635003977 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 515635003978 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 515635003979 catalytic residues [active] 515635003980 Radical SAM superfamily; Region: Radical_SAM; pfam04055 515635003981 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 515635003982 FeS/SAM binding site; other site 515635003983 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 515635003984 Radical SAM superfamily; Region: Radical_SAM; pfam04055 515635003985 FeS/SAM binding site; other site 515635003986 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 515635003987 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 515635003988 active site 515635003989 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 515635003990 nucleoside/Zn binding site; other site 515635003991 dimer interface [polypeptide binding]; other site 515635003992 catalytic motif [active] 515635003993 Uncharacterized protein involved in tolerance to divalent cations [Inorganic ion transport and metabolism]; Region: CutA; COG1324 515635003994 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 515635003995 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 515635003996 active site 515635003997 motif I; other site 515635003998 motif II; other site 515635003999 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 515635004000 radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936 515635004001 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 515635004002 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cd02065 515635004003 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 515635004004 FeS/SAM binding site; other site 515635004005 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 515635004006 Protein of unknown function (DUF1015); Region: DUF1015; pfam06245 515635004007 PAS domain; Region: PAS_8; pfam13188 515635004008 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 515635004009 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 515635004010 dimer interface [polypeptide binding]; other site 515635004011 phosphorylation site [posttranslational modification] 515635004012 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 515635004013 ATP binding site [chemical binding]; other site 515635004014 Mg2+ binding site [ion binding]; other site 515635004015 G-X-G motif; other site 515635004016 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 515635004017 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 515635004018 active site 515635004019 phosphorylation site [posttranslational modification] 515635004020 intermolecular recognition site; other site 515635004021 dimerization interface [polypeptide binding]; other site 515635004022 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 515635004023 DNA binding site [nucleotide binding] 515635004024 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 515635004025 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 515635004026 catalytic residue [active] 515635004027 HlyD family secretion protein; Region: HlyD_2; pfam12700 515635004028 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 515635004029 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 515635004030 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 515635004031 FeS/SAM binding site; other site 515635004032 cell division protein FtsZ; Validated; Region: PRK09330 515635004033 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 515635004034 nucleotide binding site [chemical binding]; other site 515635004035 SulA interaction site; other site 515635004036 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 515635004037 Cell division protein FtsA; Region: FtsA; smart00842 515635004038 Cell division protein FtsA; Region: FtsA; pfam14450 515635004039 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 515635004040 FAD binding domain; Region: FAD_binding_4; pfam01565 515635004041 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 515635004042 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 515635004043 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 515635004044 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 515635004045 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 515635004046 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 515635004047 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 515635004048 active site 515635004049 homodimer interface [polypeptide binding]; other site 515635004050 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 515635004051 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 515635004052 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK14106 515635004053 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 515635004054 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 515635004055 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 515635004056 putative catalytic motif [active] 515635004057 putative substrate binding site [chemical binding]; other site 515635004058 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 515635004059 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 515635004060 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 515635004061 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 515635004062 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 515635004063 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 515635004064 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 515635004065 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 515635004066 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 515635004067 Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717 515635004068 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 515635004069 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 515635004070 cell division protein MraZ; Reviewed; Region: PRK00326 515635004071 MraZ protein; Region: MraZ; pfam02381 515635004072 MraZ protein; Region: MraZ; pfam02381 515635004073 lysyl-tRNA synthetase; Reviewed; Region: lysK; PRK00750 515635004074 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 515635004075 Hantavirus nucleocapsid protein; Region: Hanta_nucleocap; pfam00846 515635004076 Putative zinc ribbon domain; Region: DUF164; pfam02591 515635004077 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 515635004078 pyridoxal 5'-phosphate binding site [chemical binding]; other site 515635004079 catalytic residue [active] 515635004080 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 515635004081 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 515635004082 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 515635004083 trimer interface [polypeptide binding]; other site 515635004084 active site 515635004085 substrate binding site [chemical binding]; other site 515635004086 CoA binding site [chemical binding]; other site 515635004087 Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits...; Region: Prefoldin; cl09111 515635004088 Thiamine transporter protein (Thia_YuaJ); Region: Thia_YuaJ; pfam09515 515635004089 Thiamine pyrophosphokinase; Region: TPK; cd07995 515635004090 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 515635004091 active site 515635004092 dimerization interface [polypeptide binding]; other site 515635004093 thiamine binding site [chemical binding]; other site 515635004094 DNA gyrase subunit A; Validated; Region: PRK05560 515635004095 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 515635004096 CAP-like domain; other site 515635004097 active site 515635004098 primary dimer interface [polypeptide binding]; other site 515635004099 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 515635004100 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 515635004101 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 515635004102 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 515635004103 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 515635004104 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 515635004105 Archease protein family (MTH1598/TM1083); Region: Archease; pfam01951 515635004106 GTP-binding protein YchF; Reviewed; Region: PRK09601 515635004107 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 515635004108 G1 box; other site 515635004109 GTP/Mg2+ binding site [chemical binding]; other site 515635004110 G2 box; other site 515635004111 Switch I region; other site 515635004112 Switch II region; other site 515635004113 G4 box; other site 515635004114 G5 box; other site 515635004115 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 515635004116 Predicted transcriptional regulator [Transcription]; Region: COG1959 515635004117 Rrf2 family protein; Region: rrf2_super; TIGR00738 515635004118 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 515635004119 PHP family phosphoesterase with a Zn ribbon [General function prediction only]; Region: COG1379 515635004120 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 515635004121 PHP-associated; Region: PHP_C; pfam13263 515635004122 ParB-like nuclease domain; Region: ParB; smart00470 515635004123 Domain of unknown function (DUF4032); Region: DUF4032; pfam13224 515635004124 Thermus thermophilus TTHA0053 and related proteins, metallophosphatase domain; Region: MPP_TTHA0053; cd07403 515635004125 putative active site [active] 515635004126 putative metal binding site [ion binding]; other site 515635004127 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 515635004128 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 515635004129 active site 515635004130 metal binding site [ion binding]; metal-binding site 515635004131 bifunctional phosphoglucose/phosphomannose isomerase; Validated; Region: PRK08674 515635004132 The members of this protein family contain the SIS (Sugar ISomerase) domain and have both the phosphoglucose isomerase (PGI) and the phosphomannose isomerase (PMI) functions. These functions catalyze the reversible reactions of glucose 6-phosphate to...; Region: SIS_PGI_PMI_1; cd05017 515635004133 dimer interface [polypeptide binding]; other site 515635004134 active site 515635004135 The members of this protein family contain the SIS (Sugar ISomerase) domain and have both the phosphoglucose isomerase (PGI) and the phosphomannose isomerase (PMI) functions. These functions catalyze the reversible reactions of glucose 6-phosphate to...; Region: SIS_PGI_PMI_2; cd05637 515635004136 dimer interface [polypeptide binding]; other site 515635004137 active site 515635004138 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 515635004139 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 515635004140 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 515635004141 active site 515635004142 HIGH motif; other site 515635004143 KMSKS motif; other site 515635004144 YaaC-like Protein; Region: YaaC; pfam14175 515635004145 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 515635004146 substrate binding pocket [chemical binding]; other site 515635004147 chain length determination region; other site 515635004148 substrate-Mg2+ binding site; other site 515635004149 catalytic residues [active] 515635004150 aspartate-rich region 1; other site 515635004151 active site lid residues [active] 515635004152 aspartate-rich region 2; other site 515635004153 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 515635004154 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 515635004155 dimer interface [polypeptide binding]; other site 515635004156 substrate binding site [chemical binding]; other site 515635004157 metal binding site [ion binding]; metal-binding site 515635004158 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 515635004159 active site 515635004160 (T/H)XGH motif; other site 515635004161 GTPase CgtA; Reviewed; Region: obgE; PRK12297 515635004162 GTP1/OBG; Region: GTP1_OBG; pfam01018 515635004163 Obg GTPase; Region: Obg; cd01898 515635004164 G1 box; other site 515635004165 GTP/Mg2+ binding site [chemical binding]; other site 515635004166 Switch I region; other site 515635004167 G2 box; other site 515635004168 G3 box; other site 515635004169 Switch II region; other site 515635004170 G4 box; other site 515635004171 G5 box; other site 515635004172 Domain of unknown function (DUF1967); Region: DUF1967; cl07779 515635004173 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 515635004174 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 515635004175 Domain of unknown function (DUF362); Region: DUF362; pfam04015 515635004176 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 515635004177 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 515635004178 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 515635004179 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 515635004180 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 515635004181 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 515635004182 Trp docking motif [polypeptide binding]; other site 515635004183 active site 515635004184 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl17483 515635004185 PQQ-like domain; Region: PQQ_2; pfam13360 515635004186 PQQ-like domain; Region: PQQ_2; pfam13360 515635004187 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 515635004188 non-specific DNA binding site [nucleotide binding]; other site 515635004189 salt bridge; other site 515635004190 sequence-specific DNA binding site [nucleotide binding]; other site 515635004191 Domain of unknown function (DUF955); Region: DUF955; pfam06114 515635004192 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 515635004193 DNA methylase; Region: N6_N4_Mtase; pfam01555 515635004194 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 515635004195 active site 515635004196 NTP binding site [chemical binding]; other site 515635004197 metal binding triad [ion binding]; metal-binding site 515635004198 antibiotic binding site [chemical binding]; other site 515635004199 DEAD-like helicases superfamily; Region: DEXDc; smart00487 515635004200 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 515635004201 ATP binding site [chemical binding]; other site 515635004202 putative Mg++ binding site [ion binding]; other site 515635004203 Positive regulator of sigma(E), RseC/MucC; Region: RseC_MucC; pfam04246 515635004204 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 515635004205 putative catalytic cysteine [active] 515635004206 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 515635004207 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 515635004208 Pyrroline-5-carboxylate reductase dimerization; Region: P5CR_dimer; pfam14748 515635004209 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 515635004210 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 515635004211 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 515635004212 protein binding site [polypeptide binding]; other site 515635004213 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 515635004214 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 515635004215 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 515635004216 MutS domain III; Region: MutS_III; pfam05192 515635004217 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 515635004218 Walker A/P-loop; other site 515635004219 ATP binding site [chemical binding]; other site 515635004220 Q-loop/lid; other site 515635004221 ABC transporter signature motif; other site 515635004222 Walker B; other site 515635004223 D-loop; other site 515635004224 H-loop/switch region; other site 515635004225 Smr domain; Region: Smr; pfam01713 515635004226 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 515635004227 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 515635004228 putative tRNA-binding site [nucleotide binding]; other site 515635004229 B3/4 domain; Region: B3_4; pfam03483 515635004230 tRNA synthetase B5 domain; Region: B5; smart00874 515635004231 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 515635004232 dimer interface [polypeptide binding]; other site 515635004233 motif 1; other site 515635004234 motif 3; other site 515635004235 motif 2; other site 515635004236 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 515635004237 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 515635004238 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 515635004239 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 515635004240 dimer interface [polypeptide binding]; other site 515635004241 motif 1; other site 515635004242 active site 515635004243 motif 2; other site 515635004244 motif 3; other site 515635004245 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 515635004246 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 515635004247 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 515635004248 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 515635004249 23S rRNA binding site [nucleotide binding]; other site 515635004250 L21 binding site [polypeptide binding]; other site 515635004251 L13 binding site [polypeptide binding]; other site 515635004252 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 515635004253 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 515635004254 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 515635004255 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 515635004256 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 515635004257 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 515635004258 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 515635004259 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 515635004260 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 515635004261 DNA binding residues [nucleotide binding] 515635004262 DNA primase; Validated; Region: dnaG; PRK05667 515635004263 CHC2 zinc finger; Region: zf-CHC2; pfam01807 515635004264 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 515635004265 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 515635004266 active site 515635004267 metal binding site [ion binding]; metal-binding site 515635004268 interdomain interaction site; other site 515635004269 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 515635004270 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 515635004271 Zn2+ binding site [ion binding]; other site 515635004272 Mg2+ binding site [ion binding]; other site 515635004273 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 515635004274 pyruvate phosphate dikinase; Provisional; Region: PRK09279 515635004275 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 515635004276 PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391 515635004277 PEP-utilizing enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 515635004278 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 515635004279 Glycyl-tRNA synthetase beta subunit; Region: tRNA_synt_2f; pfam02092 515635004280 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 515635004281 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 515635004282 dimer interface [polypeptide binding]; other site 515635004283 motif 1; other site 515635004284 active site 515635004285 motif 2; other site 515635004286 motif 3; other site 515635004287 Recombination protein O N terminal; Region: RecO_N; pfam11967 515635004288 DNA repair protein RecO; Region: reco; TIGR00613 515635004289 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 515635004290 intersubunit interface [polypeptide binding]; other site 515635004291 active site 515635004292 catalytic residue [active] 515635004293 GTPase Era; Reviewed; Region: era; PRK00089 515635004294 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 515635004295 G1 box; other site 515635004296 GTP/Mg2+ binding site [chemical binding]; other site 515635004297 Switch I region; other site 515635004298 G2 box; other site 515635004299 Switch II region; other site 515635004300 G3 box; other site 515635004301 G4 box; other site 515635004302 G5 box; other site 515635004303 KH domain; Region: KH_2; pfam07650 515635004304 Cytidine deaminase [Nucleotide transport and metabolism]; Region: Cdd; COG0295 515635004305 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 515635004306 active site 515635004307 catalytic motif [active] 515635004308 Zn binding site [ion binding]; other site 515635004309 CTP synthetase; Validated; Region: pyrG; PRK05380 515635004310 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 515635004311 Catalytic site [active] 515635004312 active site 515635004313 UTP binding site [chemical binding]; other site 515635004314 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 515635004315 active site 515635004316 putative oxyanion hole; other site 515635004317 catalytic triad [active] 515635004318 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 515635004319 Domain of unknown function DUF21; Region: DUF21; pfam01595 515635004320 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 515635004321 Transporter associated domain; Region: CorC_HlyC; smart01091 515635004322 Integral membrane diacylglycerol kinase and similar enzymes; Region: DAGK_IM_like; cd14263 515635004323 trimer interface [polypeptide binding]; other site 515635004324 putative active site [active] 515635004325 Zn binding site [ion binding]; other site 515635004326 metal-binding heat shock protein; Provisional; Region: PRK00016 515635004327 PhoH-like protein; Region: PhoH; pfam02562 515635004328 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 515635004329 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 515635004330 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 515635004331 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 515635004332 FeS/SAM binding site; other site 515635004333 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 515635004334 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 515635004335 HrcA protein C terminal domain; Region: HrcA; pfam01628 515635004336 Serine dehydrogenase proteinase; Region: SDH_sah; pfam01972 515635004337 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 515635004338 active site 515635004339 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 515635004340 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 515635004341 homotrimer interaction site [polypeptide binding]; other site 515635004342 putative active site [active] 515635004343 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 515635004344 active site 515635004345 dimerization interface [polypeptide binding]; other site 515635004346 ribonuclease PH; Reviewed; Region: rph; PRK00173 515635004347 Ribonuclease PH; Region: RNase_PH_bact; cd11362 515635004348 hexamer interface [polypeptide binding]; other site 515635004349 active site 515635004350 type I secretion system ABC transporter, PrtD family; Region: type_I_sec_PrtD; TIGR01842 515635004351 Fumarase C-terminus; Region: Fumerase_C; pfam05683 515635004352 fumarate hydratase; Provisional; Region: PRK06246 515635004353 Domain of unknown function (DUF4387); Region: DUF4387; pfam14330 515635004354 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 515635004355 methylaspartate ammonia-lyase; Region: B_methylAsp_ase; TIGR01502 515635004356 Methylaspartate ammonia lyase (3-methylaspartase, MAL) is a homodimeric enzyme, catalyzing the magnesium-dependent reversible alpha,beta-elimination of ammonia from L-threo-(2S,3S)-3-methylaspartic acid to mesaconic acid. This reaction is part of the...; Region: MAL; cd03314 515635004357 dimer interface [polypeptide binding]; other site 515635004358 active site 515635004359 Coenzyme B12-dependent glutamate mutase epsilon subunit-like family; contains proteins similar to Clostridium cochlearium glutamate mutase (Glm) and Streptomyces tendae Tu901 NikV. Glm catalyzes a carbon-skeleton rearrangement of L-glutamate to...; Region: Glm_e; cd00245 515635004360 substrate binding site [chemical binding]; other site 515635004361 B12 cofactor binding site [chemical binding]; other site 515635004362 heterodimer (sigma-epsilon) interface [polypeptide binding]; other site 515635004363 homodimer (epsilon-epsilon) interface [polypeptide binding]; other site 515635004364 MutL protein; Region: MutL; pfam13941 515635004365 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 515635004366 B12 binding domain of glutamate mutase (Glm). Glutamate mutase catalysis the conversion of (S)-glutamate with (2S,3S)-3-methylaspartate. The rearrangement reaction is initiated by the extraction of a hydrogen from the protein-bound substrate by a 5'...; Region: Glm_B12_BD; cd02072 515635004367 B12 binding site [chemical binding]; other site 515635004368 heterodimer interface [polypeptide binding]; other site 515635004369 cobalt ligand [ion binding]; other site 515635004370 M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683 515635004371 peptidase T-like protein; Region: PepT-like; TIGR01883 515635004372 metal binding site [ion binding]; metal-binding site 515635004373 putative dimer interface [polypeptide binding]; other site 515635004374 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 515635004375 AMIN domain; Region: AMIN; pfam11741 515635004376 AMIN domain; Region: AMIN; pfam11741 515635004377 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 515635004378 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 515635004379 active site 515635004380 metal binding site [ion binding]; metal-binding site 515635004381 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 515635004382 SmpB-tmRNA interface; other site 515635004383 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 515635004384 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 515635004385 NAD binding site [chemical binding]; other site 515635004386 homodimer interface [polypeptide binding]; other site 515635004387 active site 515635004388 substrate binding site [chemical binding]; other site 515635004389 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 515635004390 inhibitor-cofactor binding pocket; inhibition site 515635004391 pyridoxal 5'-phosphate binding site [chemical binding]; other site 515635004392 catalytic residue [active] 515635004393 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 515635004394 Chain length determinant protein; Region: Wzz; pfam02706 515635004395 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 515635004396 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 515635004397 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 515635004398 nucleotide binding site [chemical binding]; other site 515635004399 N-acetyl-L-glutamate binding site [chemical binding]; other site 515635004400 GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100 515635004401 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 515635004402 G1 box; other site 515635004403 GTP/Mg2+ binding site [chemical binding]; other site 515635004404 G2 box; other site 515635004405 Switch I region; other site 515635004406 G3 box; other site 515635004407 Switch II region; other site 515635004408 G4 box; other site 515635004409 G5 box; other site 515635004410 Roadblock/LC7 domain; Region: Robl_LC7; smart00960 515635004411 replicative DNA helicase; Region: DnaB; TIGR00665 515635004412 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 515635004413 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 515635004414 Walker A motif; other site 515635004415 ATP binding site [chemical binding]; other site 515635004416 Walker B motif; other site 515635004417 DNA binding loops [nucleotide binding] 515635004418 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 515635004419 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 515635004420 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 515635004421 Predicted membrane protein (DUF2232); Region: DUF2232; cl01728 515635004422 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 515635004423 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 515635004424 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 515635004425 dimer interface [polypeptide binding]; other site 515635004426 ssDNA binding site [nucleotide binding]; other site 515635004427 tetramer (dimer of dimers) interface [polypeptide binding]; other site 515635004428 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 515635004429 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 515635004430 homodimer interface [polypeptide binding]; other site 515635004431 substrate-cofactor binding pocket; other site 515635004432 pyridoxal 5'-phosphate binding site [chemical binding]; other site 515635004433 catalytic residue [active] 515635004434 diaminopimelate decarboxylase; Region: lysA; TIGR01048 515635004435 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 515635004436 active site 515635004437 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 515635004438 substrate binding site [chemical binding]; other site 515635004439 catalytic residues [active] 515635004440 dimer interface [polypeptide binding]; other site 515635004441 homoserine dehydrogenase; Provisional; Region: PRK06349 515635004442 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 515635004443 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 515635004444 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 515635004445 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 515635004446 cysteine synthase; Region: PLN02565 515635004447 homodimer interface [polypeptide binding]; other site 515635004448 pyridoxal 5'-phosphate binding site [chemical binding]; other site 515635004449 catalytic residue [active] 515635004450 homoserine kinase; Provisional; Region: PRK01212 515635004451 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 515635004452 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 515635004453 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; pfam01118 515635004454 Semialdehyde dehydrogenase, dimerization domain; Region: Semialdhyde_dhC; pfam02774 515635004455 aspartate kinase; Reviewed; Region: PRK06635 515635004456 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 515635004457 putative nucleotide binding site [chemical binding]; other site 515635004458 putative catalytic residues [active] 515635004459 putative Mg ion binding site [ion binding]; other site 515635004460 putative aspartate binding site [chemical binding]; other site 515635004461 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 515635004462 putative allosteric regulatory site; other site 515635004463 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AK-LysC-DapG-like_2; cd04923 515635004464 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 515635004465 core dimer interface [polypeptide binding]; other site 515635004466 peripheral dimer interface [polypeptide binding]; other site 515635004467 L10 interface [polypeptide binding]; other site 515635004468 L11 interface [polypeptide binding]; other site 515635004469 putative EF-Tu interaction site [polypeptide binding]; other site 515635004470 putative EF-G interaction site [polypeptide binding]; other site 515635004471 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 515635004472 23S rRNA interface [nucleotide binding]; other site 515635004473 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 515635004474 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 515635004475 mRNA/rRNA interface [nucleotide binding]; other site 515635004476 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 515635004477 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 515635004478 23S rRNA interface [nucleotide binding]; other site 515635004479 L7/L12 interface [polypeptide binding]; other site 515635004480 putative thiostrepton binding site; other site 515635004481 L25 interface [polypeptide binding]; other site 515635004482 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 515635004483 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 515635004484 putative homodimer interface [polypeptide binding]; other site 515635004485 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 515635004486 heterodimer interface [polypeptide binding]; other site 515635004487 homodimer interface [polypeptide binding]; other site 515635004488 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584 515635004489 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 515635004490 elongation factor Tu; Reviewed; Region: PRK00049 515635004491 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 515635004492 G1 box; other site 515635004493 GEF interaction site [polypeptide binding]; other site 515635004494 GTP/Mg2+ binding site [chemical binding]; other site 515635004495 Switch I region; other site 515635004496 G2 box; other site 515635004497 G3 box; other site 515635004498 Switch II region; other site 515635004499 G4 box; other site 515635004500 G5 box; other site 515635004501 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 515635004502 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 515635004503 Antibiotic Binding Site [chemical binding]; other site 515635004504 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 515635004505 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 515635004506 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 515635004507 RNA binding site [nucleotide binding]; other site 515635004508 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 515635004509 RNA binding site [nucleotide binding]; other site 515635004510 S1 RNA binding domain; Region: S1; pfam00575 515635004511 RNA binding site [nucleotide binding]; other site 515635004512 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 515635004513 RNA binding site [nucleotide binding]; other site 515635004514 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 515635004515 RNA binding site [nucleotide binding]; other site 515635004516 Protein of unknown function (DUF3584); Region: DUF3584; pfam12128 515635004517 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 515635004518 seryl-tRNA synthetase; Provisional; Region: PRK05431 515635004519 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 515635004520 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 515635004521 dimer interface [polypeptide binding]; other site 515635004522 active site 515635004523 motif 1; other site 515635004524 motif 2; other site 515635004525 motif 3; other site 515635004526 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08665 515635004527 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 515635004528 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 515635004529 active site 515635004530 dimer interface [polypeptide binding]; other site 515635004531 effector binding site; other site 515635004532 TSCPD domain; Region: TSCPD; pfam12637 515635004533 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 515635004534 O-antigen ligase like membrane protein; Region: O-antigen_lig; cl04850 515635004535 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 515635004536 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 515635004537 binding surface 515635004538 TPR motif; other site 515635004539 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 515635004540 binding surface 515635004541 TPR motif; other site 515635004542 phosphofructokinase; Region: PFK_mixed; TIGR02483 515635004543 active site 515635004544 ADP/pyrophosphate binding site [chemical binding]; other site 515635004545 dimerization interface [polypeptide binding]; other site 515635004546 allosteric effector site; other site 515635004547 fructose-1,6-bisphosphate binding site; other site 515635004548 Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; pfam09835 515635004549 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 515635004550 nucleotide binding site/active site [active] 515635004551 HIT family signature motif; other site 515635004552 catalytic residue [active] 515635004553 6-phosphofructokinase; Provisional; Region: PRK03202 515635004554 active site 515635004555 ADP/pyrophosphate binding site [chemical binding]; other site 515635004556 dimerization interface [polypeptide binding]; other site 515635004557 allosteric effector site; other site 515635004558 fructose-1,6-bisphosphate binding site; other site 515635004559 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172 515635004560 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172 515635004561 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06826 515635004562 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 515635004563 active site 515635004564 PHP Thumb interface [polypeptide binding]; other site 515635004565 metal binding site [ion binding]; metal-binding site 515635004566 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 515635004567 Helix-hairpin-helix motif; Region: HHH_6; pfam14579 515635004568 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 515635004569 generic binding surface II; other site 515635004570 generic binding surface I; other site 515635004571 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 515635004572 Fe-S cluster binding site [ion binding]; other site 515635004573 active site 515635004574 Methyltransferase domain; Region: Methyltransf_31; pfam13847 515635004575 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 515635004576 S-adenosylmethionine binding site [chemical binding]; other site 515635004577 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 515635004578 S-adenosylmethionine binding site [chemical binding]; other site 515635004579 Acylphosphatase; Region: Acylphosphatase; pfam00708 515635004580 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 515635004581 Part of AAA domain; Region: AAA_19; pfam13245 515635004582 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 515635004583 Septum formation topological specificity factor MinE; Region: MinE; cl00538 515635004584 septum site-determining protein MinD; Region: minD_bact; TIGR01968 515635004585 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 515635004586 P-loop; other site 515635004587 ADP binding residues [chemical binding]; other site 515635004588 Switch I; other site 515635004589 Switch II; other site 515635004590 septum site-determining protein MinC; Region: minC; TIGR01222 515635004591 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 515635004592 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 515635004593 Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717 515635004594 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 515635004595 rod shape-determining protein MreC; Provisional; Region: PRK13922 515635004596 rod shape-determining protein MreB; Provisional; Region: PRK13927 515635004597 MreB and similar proteins; Region: MreB_like; cd10225 515635004598 nucleotide binding site [chemical binding]; other site 515635004599 Mg binding site [ion binding]; other site 515635004600 putative protofilament interaction site [polypeptide binding]; other site 515635004601 RodZ interaction site [polypeptide binding]; other site 515635004602 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 515635004603 active site 515635004604 dimer interface [polypeptide binding]; other site 515635004605 Uncharacterized conserved protein [Function unknown]; Region: COG1284 515635004606 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 515635004607 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 515635004608 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 515635004609 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 515635004610 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 515635004611 peptide chain release factor 2; Provisional; Region: PRK05589 515635004612 This domain is found in peptide chain release factors; Region: PCRF; smart00937 515635004613 RF-1 domain; Region: RF-1; pfam00472 515635004614 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 515635004615 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 515635004616 ATP binding site [chemical binding]; other site 515635004617 putative Mg++ binding site [ion binding]; other site 515635004618 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 515635004619 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 515635004620 nucleotide binding region [chemical binding]; other site 515635004621 ATP-binding site [chemical binding]; other site 515635004622 SecA Wing and Scaffold domain; Region: SecA_SW; pfam07516 515635004623 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 515635004624 30S subunit binding site; other site 515635004625 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 515635004626 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 515635004627 active site 515635004628 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 515635004629 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 515635004630 active site 515635004631 homodimer interface [polypeptide binding]; other site 515635004632 Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593 515635004633 putative active site [active] 515635004634 Mn binding site [ion binding]; other site 515635004635 S-adenosylmethionine decarboxylase; Region: AdoMet_dc; pfam02675 515635004636 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 515635004637 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 515635004638 ATP-grasp domain; Region: ATP-grasp_4; cl17255 515635004639 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 515635004640 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 515635004641 active site 515635004642 substrate binding site [chemical binding]; other site 515635004643 cosubstrate binding site; other site 515635004644 catalytic site [active] 515635004645 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 515635004646 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 515635004647 dimerization interface [polypeptide binding]; other site 515635004648 putative ATP binding site [chemical binding]; other site 515635004649 Glutamine phosphoribosylpyrophosphate amidotransferase [Nucleotide transport and metabolism]; Region: PurF; COG0034 515635004650 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 515635004651 active site 515635004652 tetramer interface [polypeptide binding]; other site 515635004653 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 515635004654 active site 515635004655 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 515635004656 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 515635004657 dimerization interface [polypeptide binding]; other site 515635004658 ATP binding site [chemical binding]; other site 515635004659 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 515635004660 dimerization interface [polypeptide binding]; other site 515635004661 ATP binding site [chemical binding]; other site 515635004662 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 515635004663 putative active site [active] 515635004664 catalytic triad [active] 515635004665 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700 515635004666 adenylosuccinate lyase; Provisional; Region: PRK07492 515635004667 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 515635004668 tetramer interface [polypeptide binding]; other site 515635004669 active site 515635004670 Adenylosuccinate lyase C-terminus; Region: ADSL_C; pfam10397 515635004671 enolase; Provisional; Region: eno; PRK00077 515635004672 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 515635004673 dimer interface [polypeptide binding]; other site 515635004674 metal binding site [ion binding]; metal-binding site 515635004675 substrate binding pocket [chemical binding]; other site 515635004676 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 515635004677 active site 515635004678 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 515635004679 nudix motif; other site 515635004680 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 515635004681 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 515635004682 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 515635004683 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 515635004684 active site 515635004685 Substrate binding site; other site 515635004686 Mg++ binding site; other site 515635004687 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 515635004688 putative trimer interface [polypeptide binding]; other site 515635004689 putative CoA binding site [chemical binding]; other site 515635004690 phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990 515635004691 GTP-mannose-1-phosphate guanyltransferase (MPG1 transferase), also known as GDP-mannose pyrophosphorylase, is a bifunctional enzyme with both phosphomannose isomerase (PMI) activity and GDP-mannose phosphorylase (GMP) activity. The protein contains an...; Region: MPG1_transferase; cd05805 515635004692 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 515635004693 Inorganic H+ pyrophosphatase; Region: H_PPase; pfam03030 515635004694 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 515635004695 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 515635004696 active site 515635004697 HIGH motif; other site 515635004698 KMSKS motif; other site 515635004699 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 515635004700 tRNA binding surface [nucleotide binding]; other site 515635004701 anticodon binding site; other site 515635004702 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 515635004703 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 515635004704 putative binding site residues; other site 515635004705 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 515635004706 ABC-ATPase subunit interface; other site 515635004707 dimer interface [polypeptide binding]; other site 515635004708 putative PBP binding regions; other site 515635004709 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 515635004710 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 515635004711 Walker A/P-loop; other site 515635004712 ATP binding site [chemical binding]; other site 515635004713 Q-loop/lid; other site 515635004714 ABC transporter signature motif; other site 515635004715 Walker B; other site 515635004716 D-loop; other site 515635004717 H-loop/switch region; other site 515635004718 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 515635004719 substrate binding site [chemical binding]; other site 515635004720 hexamer interface [polypeptide binding]; other site 515635004721 metal binding site [ion binding]; metal-binding site 515635004722 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 515635004723 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 515635004724 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 515635004725 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 515635004726 FeS/SAM binding site; other site 515635004727 16S rRNA methyltransferase B; Provisional; Region: PRK14902 515635004728 NusB family; Region: NusB; pfam01029 515635004729 putative RNA binding site [nucleotide binding]; other site 515635004730 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 515635004731 S-adenosylmethionine binding site [chemical binding]; other site 515635004732 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298 515635004733 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 515635004734 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 515635004735 putative active site [active] 515635004736 substrate binding site [chemical binding]; other site 515635004737 putative cosubstrate binding site; other site 515635004738 catalytic site [active] 515635004739 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 515635004740 substrate binding site [chemical binding]; other site 515635004741 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 515635004742 active site 515635004743 catalytic residues [active] 515635004744 metal binding site [ion binding]; metal-binding site 515635004745 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 515635004746 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 515635004747 Guanylate kinase; Region: Guanylate_kin; pfam00625 515635004748 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 515635004749 catalytic site [active] 515635004750 G-X2-G-X-G-K; other site 515635004751 hypothetical protein; Provisional; Region: PRK04323 515635004752 hypothetical protein; Provisional; Region: PRK11820 515635004753 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 515635004754 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 515635004755 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 515635004756 putative SAM binding site [chemical binding]; other site 515635004757 putative homodimer interface [polypeptide binding]; other site 515635004758 putative phosphate acyltransferase; Provisional; Region: PRK05331 515635004759 Tfp pilus assembly protein, ATPase PilU [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilU; COG5008 515635004760 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 515635004761 Walker A motif; other site 515635004762 ATP binding site [chemical binding]; other site 515635004763 Walker B motif; other site 515635004764 This family is most closely related to the GT1 family of glycosyltransferases. ORF704 in E. coli has been shown to be involved in the biosynthesis of O-specific mannose homopolysaccharides; Region: GT1_ecORF704_like; cd03822 515635004765 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 515635004766 Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u2; cd10926 515635004767 putative active site [active] 515635004768 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 515635004769 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 515635004770 DXD motif; other site 515635004771 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 515635004772 trimer interface [polypeptide binding]; other site 515635004773 active site 515635004774 dimer interface [polypeptide binding]; other site 515635004775 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 515635004776 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 515635004777 ADP binding site [chemical binding]; other site 515635004778 magnesium binding site [ion binding]; other site 515635004779 putative shikimate binding site; other site 515635004780 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 515635004781 S-adenosylmethionine binding site [chemical binding]; other site 515635004782 S-adenosylmethionine decarboxylase proenzyme; Provisional; Region: PRK03124 515635004783 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 515635004784 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 515635004785 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 515635004786 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 515635004787 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 515635004788 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 515635004789 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 515635004790 FeS/SAM binding site; other site 515635004791 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 515635004792 non-specific DNA binding site [nucleotide binding]; other site 515635004793 salt bridge; other site 515635004794 sequence-specific DNA binding site [nucleotide binding]; other site 515635004795 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 515635004796 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 515635004797 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 515635004798 RNA binding surface [nucleotide binding]; other site 515635004799 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 515635004800 active site 515635004801 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 515635004802 ScpA/B protein; Region: ScpA_ScpB; cl00598 515635004803 tryptophanyl-tRNA synthetase; Reviewed; Region: PRK00927 515635004804 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 515635004805 active site 515635004806 HIGH motif; other site 515635004807 dimer interface [polypeptide binding]; other site 515635004808 KMSKS motif; other site 515635004809 Peptidase family M50; Region: Peptidase_M50; pfam02163 515635004810 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 515635004811 active site 515635004812 putative substrate binding region [chemical binding]; other site 515635004813 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 515635004814 pyrimidine-nucleoside phosphorylase; Region: Y_phosphoryl; TIGR02644 515635004815 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 515635004816 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 515635004817 phosphopentomutase; Provisional; Region: PRK05362 515635004818 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 515635004819 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 515635004820 active site 515635004821 Int/Topo IB signature motif; other site 515635004822 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 515635004823 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 515635004824 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 515635004825 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 515635004826 homotrimer interaction site [polypeptide binding]; other site 515635004827 zinc binding site [ion binding]; other site 515635004828 CDP-binding sites; other site 515635004829 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 515635004830 substrate binding site; other site 515635004831 dimer interface; other site 515635004832 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 515635004833 putative active site [active] 515635004834 TRAM domain; Region: TRAM; cl01282 515635004835 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 515635004836 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 515635004837 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 515635004838 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 515635004839 DNA repair protein RadA; Provisional; Region: PRK11823 515635004840 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 515635004841 Walker A motif; other site 515635004842 ATP binding site [chemical binding]; other site 515635004843 Walker B motif; other site 515635004844 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 515635004845 Clp protease ATP binding subunit; Region: clpC; CHL00095 515635004846 Clp amino terminal domain; Region: Clp_N; pfam02861 515635004847 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 515635004848 Walker A motif; other site 515635004849 ATP binding site [chemical binding]; other site 515635004850 Walker B motif; other site 515635004851 arginine finger; other site 515635004852 UvrB/uvrC motif; Region: UVR; pfam02151 515635004853 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 515635004854 Walker A motif; other site 515635004855 ATP binding site [chemical binding]; other site 515635004856 Walker B motif; other site 515635004857 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 515635004858 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 515635004859 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 515635004860 ADP binding site [chemical binding]; other site 515635004861 phosphagen binding site; other site 515635004862 substrate specificity loop; other site 515635004863 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 515635004864 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cd09680 515635004865 UvrB/uvrC motif; Region: UVR; pfam02151 515635004866 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 515635004867 predicted active site [active] 515635004868 catalytic triad [active] 515635004869 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 515635004870 active site 515635004871 multimer interface [polypeptide binding]; other site 515635004872 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 515635004873 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 515635004874 GIY-YIG motif/motif A; other site 515635004875 active site 515635004876 catalytic site [active] 515635004877 putative DNA binding site [nucleotide binding]; other site 515635004878 metal binding site [ion binding]; metal-binding site 515635004879 UvrB/uvrC motif; Region: UVR; pfam02151 515635004880 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 515635004881 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 515635004882 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 515635004883 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 515635004884 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 515635004885 active site 515635004886 HIGH motif; other site 515635004887 KMSK motif region; other site 515635004888 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 515635004889 tRNA binding surface [nucleotide binding]; other site 515635004890 anticodon binding site; other site 515635004891 Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483 515635004892 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 515635004893 QueT transporter; Region: QueT; pfam06177 515635004894 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 515635004895 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 515635004896 active site 515635004897 HIGH motif; other site 515635004898 dimer interface [polypeptide binding]; other site 515635004899 KMSKS motif; other site 515635004900 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 515635004901 RNA binding surface [nucleotide binding]; other site 515635004902 Domain of unknown function (DUF348); Region: DUF348; pfam03990 515635004903 G5 domain; Region: G5; pfam07501 515635004904 3D domain; Region: 3D; cl01439 515635004905 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 515635004906 S-adenosylmethionine binding site [chemical binding]; other site 515635004907 4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate synthase [Lipid metabolism]; Region: IspE; COG1947 515635004908 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 515635004909 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 515635004910 threonine dehydratase; Provisional; Region: PRK08198 515635004911 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 515635004912 tetramer interface [polypeptide binding]; other site 515635004913 pyridoxal 5'-phosphate binding site [chemical binding]; other site 515635004914 catalytic residue [active] 515635004915 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 515635004916 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 515635004917 oligomer interface [polypeptide binding]; other site 515635004918 active site 515635004919 metal binding site [ion binding]; metal-binding site 515635004920 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 515635004921 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 515635004922 Ligand Binding Site [chemical binding]; other site 515635004923 Domain of unknown function (DUF814); Region: DUF814; pfam05670 515635004924 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 515635004925 DHH family; Region: DHH; pfam01368 515635004926 FOG: CBS domain [General function prediction only]; Region: COG0517 515635004927 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with an upstream DHH domain which performs a phosphoesterase function and a downstream polyA polymerase domain. CBS is a small domain originally...; Region: CBS_pair_DHH_polyA_Pol_assoc; cd04595 515635004928 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 515635004929 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 515635004930 active site 515635004931 NTP binding site [chemical binding]; other site 515635004932 metal binding triad [ion binding]; metal-binding site 515635004933 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 515635004934 alanine racemase; Reviewed; Region: alr; PRK00053 515635004935 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 515635004936 active site 515635004937 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 515635004938 dimer interface [polypeptide binding]; other site 515635004939 substrate binding site [chemical binding]; other site 515635004940 catalytic residues [active] 515635004941 ATP synthase subunit D; Region: ATP-synt_D; cl00613 515635004942 V-type ATP synthase subunit B; Provisional; Region: PRK04196 515635004943 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 515635004944 V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_B; cd01135 515635004945 Walker A motif homologous position; other site 515635004946 Walker B motif; other site 515635004947 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 515635004948 V-type ATP synthase subunit A; Provisional; Region: PRK04192 515635004949 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 515635004950 V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_A; cd01134 515635004951 Walker A motif/ATP binding site; other site 515635004952 Walker B motif; other site 515635004953 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 515635004954 ATP synthase (F/14-kDa) subunit; Region: ATP-synt_F; cl00632 515635004955 Archaeal/vacuolar-type H+-ATPase subunit E [Energy production and conversion]; Region: NtpE; COG1390 515635004956 V-type ATP synthase subunit K; Provisional; Region: PRK14893 515635004957 ATP synthase subunit C; Region: ATP-synt_C; pfam00137 515635004958 ATP synthase subunit C; Region: ATP-synt_C; pfam00137 515635004959 V-type ATP synthase subunit I; Validated; Region: PRK05771 515635004960 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915 515635004961 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 515635004962 Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility; Region: MEMO_like; cd07361 515635004963 putative ligand binding pocket/active site [active] 515635004964 putative metal binding site [ion binding]; other site 515635004965 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 515635004966 putative active site [active] 515635004967 catalytic residue [active] 515635004968 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 515635004969 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 515635004970 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 515635004971 ATP binding site [chemical binding]; other site 515635004972 putative Mg++ binding site [ion binding]; other site 515635004973 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 515635004974 nucleotide binding region [chemical binding]; other site 515635004975 ATP-binding site [chemical binding]; other site 515635004976 TRCF domain; Region: TRCF; pfam03461 515635004977 SurA N-terminal domain; Region: SurA_N_3; cl07813 515635004978 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 515635004979 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 515635004980 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 515635004981 homodimer interface [polypeptide binding]; other site 515635004982 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 515635004983 metal binding site [ion binding]; metal-binding site 515635004984 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 515635004985 homodimer interface [polypeptide binding]; other site 515635004986 active site 515635004987 putative chemical substrate binding site [chemical binding]; other site 515635004988 metal binding site [ion binding]; metal-binding site 515635004989 histone-like DNA-binding protein HU; Region: HU; cd13831 515635004990 dimer interface [polypeptide binding]; other site 515635004991 DNA binding site [nucleotide binding] 515635004992 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 515635004993 Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571 515635004994 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 515635004995 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 515635004996 lipoyl attachment site [posttranslational modification]; other site 515635004997 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 515635004998 tetramer interface [polypeptide binding]; other site 515635004999 pyridoxal 5'-phosphate binding site [chemical binding]; other site 515635005000 catalytic residue [active] 515635005001 glycine dehydrogenase subunit 2; Validated; Region: PRK04366 515635005002 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 515635005003 catalytic residue [active] 515635005004 Uncharacterized homolog of biotin synthetase [Function unknown]; Region: COG1856 515635005005 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl18962 515635005006 Biotin synthase-related enzyme [General function prediction only]; Region: COG2516 515635005007 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 515635005008 FeS/SAM binding site; other site 515635005009 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 515635005010 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 515635005011 active site 515635005012 NTP binding site [chemical binding]; other site 515635005013 metal binding triad [ion binding]; metal-binding site 515635005014 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 515635005015 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cl17503 515635005016 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 515635005017 Zn2+ binding site [ion binding]; other site 515635005018 Mg2+ binding site [ion binding]; other site 515635005019 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 515635005020 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 515635005021 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 515635005022 active site 515635005023 DNA binding site [nucleotide binding] 515635005024 Int/Topo IB signature motif; other site 515635005025 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 515635005026 Glucose inhibited division protein A; Region: GIDA; pfam01134 515635005027 DNA topoisomerase I; Validated; Region: PRK05582 515635005028 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 515635005029 active site 515635005030 interdomain interaction site; other site 515635005031 putative metal-binding site [ion binding]; other site 515635005032 nucleotide binding site [chemical binding]; other site 515635005033 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 515635005034 domain I; other site 515635005035 DNA binding groove [nucleotide binding] 515635005036 phosphate binding site [ion binding]; other site 515635005037 domain II; other site 515635005038 domain III; other site 515635005039 nucleotide binding site [chemical binding]; other site 515635005040 catalytic site [active] 515635005041 domain IV; other site 515635005042 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 515635005043 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 515635005044 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 515635005045 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 515635005046 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 515635005047 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 515635005048 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 515635005049 Walker A motif; other site 515635005050 ATP binding site [chemical binding]; other site 515635005051 Walker B motif; other site 515635005052 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 515635005053 hypothetical protein; Reviewed; Region: PRK12497 515635005054 Bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 515635005055 RNA/DNA hybrid binding site [nucleotide binding]; other site 515635005056 active site 515635005057 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 515635005058 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 515635005059 Catalytic site [active] 515635005060 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465 515635005061 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 515635005062 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 515635005063 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 515635005064 RimM N-terminal domain; Region: RimM; pfam01782 515635005065 PRC-barrel domain; Region: PRC; pfam05239 515635005066 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 515635005067 G-X-X-G motif; other site 515635005068 ribosomal protein S16; Region: S16; TIGR00002 515635005069 signal recognition particle protein; Provisional; Region: PRK10867 515635005070 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 515635005071 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 515635005072 P loop; other site 515635005073 GTP binding site [chemical binding]; other site 515635005074 Signal peptide binding domain; Region: SRP_SPB; pfam02978 515635005075 beta-D-glucuronidase; Provisional; Region: PRK10150 515635005076 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 515635005077 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 515635005078 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 515635005079 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 515635005080 dimerization interface [polypeptide binding]; other site 515635005081 putative DNA binding site [nucleotide binding]; other site 515635005082 putative Zn2+ binding site [ion binding]; other site 515635005083 Protein of unknown function (DUF554); Region: DUF554; pfam04474 515635005084 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 515635005085 GMP synthase; Reviewed; Region: guaA; PRK00074 515635005086 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 515635005087 AMP/PPi binding site [chemical binding]; other site 515635005088 candidate oxyanion hole; other site 515635005089 catalytic triad [active] 515635005090 potential glutamine specificity residues [chemical binding]; other site 515635005091 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 515635005092 ATP Binding subdomain [chemical binding]; other site 515635005093 Ligand Binding sites [chemical binding]; other site 515635005094 Dimerization subdomain; other site 515635005095 Protein of unknown function DUF111; Region: DUF111; pfam01969 515635005096 NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691 515635005097 AIR carboxylase; Region: AIRC; smart01001 515635005098 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 515635005099 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 515635005100 ATP binding site [chemical binding]; other site 515635005101 Mg2+ binding site [ion binding]; other site 515635005102 G-X-G motif; other site 515635005103 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 515635005104 anchoring element; other site 515635005105 dimer interface [polypeptide binding]; other site 515635005106 ATP binding site [chemical binding]; other site 515635005107 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 515635005108 active site 515635005109 putative metal-binding site [ion binding]; other site 515635005110 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 515635005111 Protein of unknown function (DUF721); Region: DUF721; pfam05258 515635005112 recombination protein F; Reviewed; Region: recF; PRK00064 515635005113 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 515635005114 Walker A/P-loop; other site 515635005115 ATP binding site [chemical binding]; other site 515635005116 Q-loop/lid; other site 515635005117 ABC transporter signature motif; other site 515635005118 Walker B; other site 515635005119 D-loop; other site 515635005120 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 515635005121 RNA binding surface [nucleotide binding]; other site 515635005122 DNA polymerase III subunit beta; Validated; Region: PRK05643 515635005123 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 515635005124 putative DNA binding surface [nucleotide binding]; other site 515635005125 dimer interface [polypeptide binding]; other site 515635005126 beta-clamp/clamp loader binding surface; other site 515635005127 beta-clamp/translesion DNA polymerase binding surface; other site 515635005128 Predicted transcriptional regulator [Transcription]; Region: COG1959 515635005129 Rrf2 family protein; Region: rrf2_super; TIGR00738 515635005130 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 515635005131 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 515635005132 Walker A/P-loop; other site 515635005133 ATP binding site [chemical binding]; other site 515635005134 Q-loop/lid; other site 515635005135 ABC transporter signature motif; other site 515635005136 Walker B; other site 515635005137 D-loop; other site 515635005138 H-loop/switch region; other site 515635005139 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 515635005140 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 515635005141 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 515635005142 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 515635005143 Coenzyme A binding pocket [chemical binding]; other site 515635005144 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 515635005145 dimerization interface [polypeptide binding]; other site 515635005146 putative DNA binding site [nucleotide binding]; other site 515635005147 putative Zn2+ binding site [ion binding]; other site 515635005148 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 515635005149 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 515635005150 putative dimer interface [polypeptide binding]; other site 515635005151 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 515635005152 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 515635005153 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 515635005154 Walker A motif; other site 515635005155 ATP binding site [chemical binding]; other site 515635005156 Walker B motif; other site 515635005157 arginine finger; other site 515635005158 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 515635005159 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 515635005160 Peptide chain release factor 1 (eRF1) [Translation, ribosomal structure and biogenesis]; Region: eRF1; COG1503 515635005161 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 515635005162 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 515635005163 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 515635005164 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 515635005165 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 515635005166 active site 515635005167 HIGH motif; other site 515635005168 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 515635005169 KMSKS motif; other site 515635005170 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 515635005171 tRNA binding surface [nucleotide binding]; other site 515635005172 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 515635005173 Zn binding site [ion binding]; other site 515635005174 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 515635005175 Acyltransferase family; Region: Acyl_transf_3; cl19154 515635005176 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 515635005177 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 515635005178 Walker A/P-loop; other site 515635005179 ATP binding site [chemical binding]; other site 515635005180 Q-loop/lid; other site 515635005181 ABC transporter signature motif; other site 515635005182 Walker B; other site 515635005183 D-loop; other site 515635005184 H-loop/switch region; other site 515635005185 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 515635005186 metal binding site 2 [ion binding]; metal-binding site 515635005187 putative DNA binding helix; other site 515635005188 metal binding site 1 [ion binding]; metal-binding site 515635005189 dimer interface [polypeptide binding]; other site 515635005190 structural Zn2+ binding site [ion binding]; other site 515635005191 FeoA domain; Region: FeoA; pfam04023 515635005192 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 515635005193 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 515635005194 G1 box; other site 515635005195 GTP/Mg2+ binding site [chemical binding]; other site 515635005196 Switch I region; other site 515635005197 G2 box; other site 515635005198 G3 box; other site 515635005199 Switch II region; other site 515635005200 G4 box; other site 515635005201 G5 box; other site 515635005202 Nucleoside recognition; Region: Gate; pfam07670 515635005203 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 515635005204 Nucleoside recognition; Region: Gate; pfam07670 515635005205 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 515635005206 active site 515635005207 dimer interface [polypeptide binding]; other site 515635005208 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 515635005209 heterodimer interface [polypeptide binding]; other site 515635005210 active site 515635005211 FMN binding site [chemical binding]; other site 515635005212 homodimer interface [polypeptide binding]; other site 515635005213 substrate binding site [chemical binding]; other site 515635005214 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 515635005215 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 515635005216 FAD binding pocket [chemical binding]; other site 515635005217 FAD binding motif [chemical binding]; other site 515635005218 phosphate binding motif [ion binding]; other site 515635005219 beta-alpha-beta structure motif; other site 515635005220 NAD binding pocket [chemical binding]; other site 515635005221 Iron coordination center [ion binding]; other site 515635005222 dihydroorotase; Validated; Region: pyrC; PRK09357 515635005223 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 515635005224 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 515635005225 active site 515635005226 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 515635005227 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 515635005228 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 515635005229 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 515635005230 active site 515635005231 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 515635005232 S-adenosylmethionine binding site [chemical binding]; other site 515635005233 Putative lysophospholipase; Region: Hydrolase_4; cl19140 515635005234 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 515635005235 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 515635005236 Uncharacterized conserved protein [Function unknown]; Region: COG2461 515635005237 Family of unknown function (DUF438); Region: DUF438; pfam04282 515635005238 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 515635005239 Fe binding site [ion binding]; other site 515635005240 NTPase; Region: NTPase_1; pfam03266 515635005241 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 515635005242 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 515635005243 uncharacterized subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_1; cd07774 515635005244 putative N- and C-terminal domain interface [polypeptide binding]; other site 515635005245 putative active site [active] 515635005246 putative MgATP binding site [chemical binding]; other site 515635005247 catalytic site [active] 515635005248 metal binding site [ion binding]; metal-binding site 515635005249 putative carbohydrate binding site [chemical binding]; other site 515635005250 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 515635005251 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 515635005252 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 515635005253 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 515635005254 Carbohydrate binding domain X2; Region: CBM_X2; pfam03442 515635005255 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 515635005256 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 515635005257 dimer interface [polypeptide binding]; other site 515635005258 conserved gate region; other site 515635005259 putative PBP binding loops; other site 515635005260 ABC-ATPase subunit interface; other site 515635005261 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 515635005262 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 515635005263 ABC-ATPase subunit interface; other site 515635005264 Mlo family; Region: Mlo; pfam03094 515635005265 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 515635005266 TPR motif; other site 515635005267 Yip1 domain; Region: Yip1; pfam04893 515635005268 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 515635005269 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 515635005270 dimer interface [polypeptide binding]; other site 515635005271 conserved gate region; other site 515635005272 putative PBP binding loops; other site 515635005273 ABC-ATPase subunit interface; other site 515635005274 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 515635005275 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 515635005276 dimer interface [polypeptide binding]; other site 515635005277 conserved gate region; other site 515635005278 putative PBP binding loops; other site 515635005279 ABC-ATPase subunit interface; other site 515635005280 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 515635005281 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 515635005282 putative metal binding site [ion binding]; other site 515635005283 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 515635005284 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 515635005285 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 515635005286 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 515635005287 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 515635005288 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 515635005289 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 515635005290 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 515635005291 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 515635005292 catalytic core [active] 515635005293 Clp amino terminal domain; Region: Clp_N; pfam02861 515635005294 Clp amino terminal domain; Region: Clp_N; pfam02861 515635005295 Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483 515635005296 hypothetical protein; Provisional; Region: PRK08609 515635005297 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 515635005298 active site 515635005299 primer binding site [nucleotide binding]; other site 515635005300 NTP binding site [chemical binding]; other site 515635005301 metal binding triad [ion binding]; metal-binding site 515635005302 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 515635005303 active site 515635005304 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 515635005305 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 515635005306 S-adenosylmethionine binding site [chemical binding]; other site 515635005307 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 515635005308 DHH family; Region: DHH; pfam01368 515635005309 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 515635005310 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 515635005311 Protein export membrane protein; Region: SecD_SecF; pfam02355 515635005312 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 515635005313 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 515635005314 Preprotein translocase subunit; Region: YajC; pfam02699 515635005315 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 515635005316 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 515635005317 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 515635005318 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 515635005319 Stage II sporulation protein; Region: SpoIID; pfam08486 515635005320 Protein of unknown function (DUF2905); Region: DUF2905; pfam11146 515635005321 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 515635005322 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 515635005323 Uncharacterized BCR, COG1636; Region: DUF208; pfam02677 515635005324 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases and ATP sulphurylases. The domain forms a apha/beta/apha fold which binds to Adenosine group; Region: Alpha_ANH_like; cd01986 515635005325 Ligand Binding Site [chemical binding]; other site 515635005326 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 515635005327 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 515635005328 Walker A motif; other site 515635005329 ATP binding site [chemical binding]; other site 515635005330 Walker B motif; other site 515635005331 arginine finger; other site 515635005332 Protein of unknown function, DUF399; Region: DUF399; cl01139 515635005333 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 515635005334 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 515635005335 RuvA N terminal domain; Region: RuvA_N; pfam01330 515635005336 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 515635005337 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 515635005338 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 515635005339 active site 515635005340 putative DNA-binding cleft [nucleotide binding]; other site 515635005341 dimer interface [polypeptide binding]; other site 515635005342 hypothetical protein; Validated; Region: PRK00110 515635005343 phosphoglycolate phosphatase; Provisional; Region: PRK01158 515635005344 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 515635005345 Uncharacterized conserved protein [Function unknown]; Region: COG0062 515635005346 putative carbohydrate kinase; Provisional; Region: PRK10565 515635005347 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 515635005348 putative substrate binding site [chemical binding]; other site 515635005349 putative ATP binding site [chemical binding]; other site 515635005350 NGN-insert domain found between N-terminal domain (D1) and C-terminal KOW domain (DIII) repeats of some N-Utilization Substance G (NusG) N-terminal (NGN); Region: NGN-insert_like; cd09910 515635005351 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 515635005352 putative FMN binding site [chemical binding]; other site 515635005353 NADPH bind site [chemical binding]; other site 515635005354 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 515635005355 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 515635005356 dimer interface [polypeptide binding]; other site 515635005357 active site 515635005358 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 515635005359 dimer interface [polypeptide binding]; other site 515635005360 active site 515635005361 Divergent PAP2 family; Region: DUF212; cl00855 515635005362 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 515635005363 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 515635005364 putative ADP-binding pocket [chemical binding]; other site 515635005365 NurA nuclease; Region: NurA; smart00933 515635005366 HerA helicase [Replication, recombination, and repair]; Region: COG0433 515635005367 Domain of unknown function DUF87; Region: DUF87; pfam01935 515635005368 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 515635005369 active site 515635005370 metal binding site [ion binding]; metal-binding site 515635005371 DNA binding site [nucleotide binding] 515635005372 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 515635005373 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 515635005374 Walker A/P-loop; other site 515635005375 ATP binding site [chemical binding]; other site 515635005376 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 515635005377 ABC transporter signature motif; other site 515635005378 Walker B; other site 515635005379 D-loop; other site 515635005380 H-loop/switch region; other site 515635005381 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 515635005382 active site 515635005383 tetramer interface; other site 515635005384 Cupin domain; Region: Cupin_2; cl17218 515635005385 trans-homoaconitate synthase; Reviewed; Region: aksA; PRK11858 515635005386 Streptomyces rubellomurinus FrbC and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_NifV; cd07939 515635005387 active site 515635005388 catalytic residues [active] 515635005389 metal binding site [ion binding]; metal-binding site 515635005390 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 515635005391 substrate binding site [chemical binding]; other site 515635005392 ligand binding site [chemical binding]; other site 515635005393 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 515635005394 substrate binding site [chemical binding]; other site 515635005395 iron-containing alcohol dehydrogenases (Fe-ADH)-like; Region: Fe-ADH; cd08551 515635005396 active site 515635005397 metal binding site [ion binding]; metal-binding site 515635005398 Putative glucose-1-phosphate thymidylyltransferase, C-terminal Left-handed parallel beta-Helix (LbH) domain: Proteins in this family show simlarity to glucose-1-phosphate adenylyltransferases in that they contain N-terminal catalytic domains that...; Region: LbH_G1P_TT_C_like; cd05636 515635005399 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 515635005400 FAD binding site [chemical binding]; other site 515635005401 Methylene-tetrahydrofolate reductase C terminal; Region: MTHFR_C; pfam12225 515635005402 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 515635005403 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190 515635005404 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 515635005405 homodimer interface [polypeptide binding]; other site 515635005406 NADP binding site [chemical binding]; other site 515635005407 substrate binding site [chemical binding]; other site 515635005408 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 515635005409 Potassium binding sites [ion binding]; other site 515635005410 Cesium cation binding sites [ion binding]; other site 515635005411 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 515635005412 active site 515635005413 metal binding site [ion binding]; metal-binding site 515635005414 homotetramer interface [polypeptide binding]; other site 515635005415 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 515635005416 FMN binding site [chemical binding]; other site 515635005417 dimer interface [polypeptide binding]; other site 515635005418 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 515635005419 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 515635005420 Chorismate mutase type II; Region: CM_2; pfam01817 515635005421 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 515635005422 Prephenate dehydratase; Region: PDT; pfam00800 515635005423 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 515635005424 putative L-Phe binding site [chemical binding]; other site 515635005425 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 515635005426 TM-ABC transporter signature motif; other site 515635005427 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 515635005428 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 515635005429 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 515635005430 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 515635005431 Walker A/P-loop; other site 515635005432 ATP binding site [chemical binding]; other site 515635005433 Q-loop/lid; other site 515635005434 ABC transporter signature motif; other site 515635005435 Walker B; other site 515635005436 D-loop; other site 515635005437 H-loop/switch region; other site 515635005438 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 515635005439 short chain dehydrogenase; Region: adh_short; pfam00106 515635005440 carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325 515635005441 NADP binding site [chemical binding]; other site 515635005442 homodimer interface [polypeptide binding]; other site 515635005443 active site 515635005444 Domain of unknown function (DUF1795); Region: DUF1795; cl02256 515635005445 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331 515635005446 TraB family; Region: TraB; pfam01963 515635005447 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 515635005448 Mechanosensitive ion channel; Region: MS_channel; pfam00924 515635005449 Rubrerythrin [Energy production and conversion]; Region: COG1592 515635005450 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 515635005451 binuclear metal center [ion binding]; other site 515635005452 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 515635005453 iron binding site [ion binding]; other site 515635005454 DOMON-like domain of copper-dependent monooxygenases and related proteins; Region: DOMON_DOH; cd09631 515635005455 putative ligand binding site [chemical binding]; other site 515635005456 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 515635005457 active site 515635005458 Protein of unknown function (DUF523); Region: DUF523; pfam04463 515635005459 Protein of unknown function (DUF1722); Region: DUF1722; cl01284 515635005460 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 515635005461 thiS-thiF/thiG interaction site; other site 515635005462 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 515635005463 ThiS interaction site; other site 515635005464 putative active site [active] 515635005465 tetramer interface [polypeptide binding]; other site 515635005466 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240 515635005467 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 515635005468 FeS/SAM binding site; other site 515635005469 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 515635005470 thiamine biosynthesis protein ThiF; Provisional; Region: PRK08644 515635005471 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196 515635005472 ATP binding site [chemical binding]; other site 515635005473 substrate interface [chemical binding]; other site 515635005474 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 515635005475 thiamine phosphate binding site [chemical binding]; other site 515635005476 active site 515635005477 pyrophosphate binding site [ion binding]; other site 515635005478 thiamine biosynthesis protein ThiC; Provisional; Region: PRK13352 515635005479 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 515635005480 dimer interface [polypeptide binding]; other site 515635005481 substrate binding site [chemical binding]; other site 515635005482 ATP binding site [chemical binding]; other site 515635005483 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 515635005484 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 515635005485 active site 515635005486 metal binding site [ion binding]; metal-binding site 515635005487 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 515635005488 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 515635005489 TM-ABC transporter signature motif; other site 515635005490 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 515635005491 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 515635005492 Walker A/P-loop; other site 515635005493 ATP binding site [chemical binding]; other site 515635005494 Q-loop/lid; other site 515635005495 ABC transporter signature motif; other site 515635005496 Walker B; other site 515635005497 D-loop; other site 515635005498 H-loop/switch region; other site 515635005499 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 515635005500 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 515635005501 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 515635005502 ligand binding site [chemical binding]; other site 515635005503 SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate...; Region: SERPIN; cd00172 515635005504 reactive center loop; other site 515635005505 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 515635005506 Melibiase; Region: Melibiase; pfam02065 515635005507 Sulfur transfer protein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ThiS; COG2104 515635005508 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 515635005509 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 515635005510 Ligand Binding Site [chemical binding]; other site 515635005511 TIGR00269 family protein; Region: TIGR00269 515635005512 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 515635005513 MPN+ (JAMM) motif; other site 515635005514 Zinc-binding site [ion binding]; other site 515635005515 putative heme d1 biosynthesis radical SAM protein NirJ2; Region: rSAM_NirJ2; TIGR04055 515635005516 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 515635005517 FeS/SAM binding site; other site 515635005518 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 515635005519 Alpha amylase catalytic domain found in bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac2_AmyA; cd11316 515635005520 Ca binding site [ion binding]; other site 515635005521 Alpha amylase, catalytic domain; Region: Alpha-amylase; pfam00128 515635005522 active site 515635005523 catalytic site [active] 515635005524 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 515635005525 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 515635005526 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 515635005527 nucleotide binding site [chemical binding]; other site 515635005528 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 515635005529 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 515635005530 NAD binding site [chemical binding]; other site 515635005531 sugar binding site [chemical binding]; other site 515635005532 divalent metal binding site [ion binding]; other site 515635005533 tetramer (dimer of dimers) interface [polypeptide binding]; other site 515635005534 dimer interface [polypeptide binding]; other site 515635005535 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Validated; Region: PRK05778 515635005536 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 515635005537 TPP-binding site [chemical binding]; other site 515635005538 Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367 515635005539 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 515635005540 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; pfam01558 515635005541 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 515635005542 dimer interface [polypeptide binding]; other site 515635005543 PYR/PP interface [polypeptide binding]; other site 515635005544 TPP binding site [chemical binding]; other site 515635005545 substrate binding site [chemical binding]; other site 515635005546 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 515635005547 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 515635005548 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 515635005549 nucleotide binding site [chemical binding]; other site 515635005550 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 515635005551 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 515635005552 Periplasmic solute binding protein family; Region: TroA; pfam01297 515635005553 intersubunit interface [polypeptide binding]; other site 515635005554 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 515635005555 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 515635005556 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 515635005557 ABC-ATPase subunit interface; other site 515635005558 dimer interface [polypeptide binding]; other site 515635005559 putative PBP binding regions; other site 515635005560 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 515635005561 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 515635005562 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 515635005563 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 515635005564 metal binding site [ion binding]; metal-binding site 515635005565 Ferritin-CCC1, N-terminal ferritin-like diiron-binding domain; Region: Ferritin_CCC1_N; cd01044 515635005566 diiron binding motif [ion binding]; other site 515635005567 CCC1-related domain of ferritin; Region: Ferritin_CCC1_C; cd02431 515635005568 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 515635005569 dimer interface [polypeptide binding]; other site 515635005570 [2Fe-2S] cluster binding site [ion binding]; other site 515635005571 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 515635005572 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 515635005573 SLBB domain; Region: SLBB; pfam10531 515635005574 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 515635005575 Thioredoxin-like [2Fe-2S] ferredoxin; Region: 2Fe-2S_thioredx; pfam01257 515635005576 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 515635005577 putative dimer interface [polypeptide binding]; other site 515635005578 [2Fe-2S] cluster binding site [ion binding]; other site 515635005579 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 515635005580 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 515635005581 substrate binding pocket [chemical binding]; other site 515635005582 membrane-bound complex binding site; other site 515635005583 hinge residues; other site 515635005584 GAF domain; Region: GAF; pfam01590 515635005585 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 515635005586 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 515635005587 Zn2+ binding site [ion binding]; other site 515635005588 Mg2+ binding site [ion binding]; other site 515635005589 Protease prsW family; Region: PrsW-protease; pfam13367 515635005590 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 515635005591 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 515635005592 motif II; other site 515635005593 Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300 515635005594 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 515635005595 NAD binding site [chemical binding]; other site 515635005596 ligand binding site [chemical binding]; other site 515635005597 catalytic site [active] 515635005598 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 515635005599 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 515635005600 active site 515635005601 HIGH motif; other site 515635005602 KMSKS motif; other site 515635005603 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 515635005604 tRNA binding surface [nucleotide binding]; other site 515635005605 anticodon binding site; other site 515635005606 CHASE4 domain; Region: CHASE4; cl01308 515635005607 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 515635005608 dimerization interface [polypeptide binding]; other site 515635005609 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 515635005610 metal binding site [ion binding]; metal-binding site 515635005611 active site 515635005612 I-site; other site 515635005613 Protein of unknown function (DUF1232); Region: DUF1232; cl01318 515635005614 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 515635005615 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 515635005616 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 515635005617 Ribosomal protein S27a; Region: Ribosomal_S27; cl00876 515635005618 ATP cone domain; Region: ATP-cone; pfam03477 515635005619 Anaerobic ribonucleoside-triphosphate reductase; Region: NRDD; pfam13597 515635005620 Class III ribonucleotide reductase; Region: RNR_III; cd01675 515635005621 effector binding site; other site 515635005622 active site 515635005623 Zn binding site [ion binding]; other site 515635005624 glycine loop; other site 515635005625 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG2; TIGR02495 515635005626 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 515635005627 FeS/SAM binding site; other site 515635005628 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 515635005629 Major Facilitator Superfamily; Region: MFS_1; pfam07690 515635005630 putative substrate translocation pore; other site 515635005631 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 515635005632 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 515635005633 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 515635005634 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_4; cd08500 515635005635 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 515635005636 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 515635005637 Walker A/P-loop; other site 515635005638 ATP binding site [chemical binding]; other site 515635005639 Q-loop/lid; other site 515635005640 ABC transporter signature motif; other site 515635005641 Walker B; other site 515635005642 D-loop; other site 515635005643 H-loop/switch region; other site 515635005644 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 515635005645 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 515635005646 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 515635005647 Walker A/P-loop; other site 515635005648 ATP binding site [chemical binding]; other site 515635005649 Q-loop/lid; other site 515635005650 ABC transporter signature motif; other site 515635005651 Walker B; other site 515635005652 D-loop; other site 515635005653 H-loop/switch region; other site 515635005654 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 515635005655 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 515635005656 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 515635005657 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 515635005658 dimer interface [polypeptide binding]; other site 515635005659 conserved gate region; other site 515635005660 putative PBP binding loops; other site 515635005661 ABC-ATPase subunit interface; other site 515635005662 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 515635005663 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 515635005664 dimer interface [polypeptide binding]; other site 515635005665 conserved gate region; other site 515635005666 putative PBP binding loops; other site 515635005667 ABC-ATPase subunit interface; other site 515635005668 Transcriptional regulators [Transcription]; Region: PurR; COG1609 515635005669 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 515635005670 DNA binding site [nucleotide binding] 515635005671 domain linker motif; other site 515635005672 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 515635005673 dimerization interface [polypeptide binding]; other site 515635005674 ligand binding site [chemical binding]; other site 515635005675 RNase_H superfamily; Region: RNase_H_2; pfam13482 515635005676 active site 515635005677 substrate binding site [chemical binding]; other site 515635005678 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 515635005679 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 515635005680 FeS/SAM binding site; other site 515635005681 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 515635005682 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 515635005683 The URO-D _like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases. Uroporphyrinogen decarboxylase (URO-D) decarboxylates the four...; Region: URO-D_like; cd03465 515635005684 Alpha-glucuronidase [Carbohydrate transport and metabolism]; Region: AguA; COG3661 515635005685 Glycosyl hydrolase family 67 N-terminus; Region: Glyco_hydro_67N; pfam03648 515635005686 Glycosyl hydrolase family 67 middle domain; Region: Glyco_hydro_67M; pfam07488 515635005687 Glycosyl hydrolase family 67 C-terminus; Region: Glyco_hydro_67C; pfam07477 515635005688 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 515635005689 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 515635005690 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331 515635005691 Domon-like ligand-binding domains; Region: DOMON_like; cl14783 515635005692 putative ligand binding site [chemical binding]; other site 515635005693 DOMON-like type 9 carbohydrate binding module of xylanases; Region: CBM9_like_1; cd00005 515635005694 Ca binding site [ion binding]; other site 515635005695 carbohydrate binding site [chemical binding]; other site 515635005696 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 515635005697 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 515635005698 Uncharacterized Fe-S center protein [General function prediction only]; Region: COG2768 515635005699 Domain of unknown function (DUF362); Region: DUF362; cl19822 515635005700 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 515635005701 Macro domain, Af1521- and BAL-like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Af1521_BAL_like; cd02907 515635005702 ADP-ribose binding site [chemical binding]; other site 515635005703 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 515635005704 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 515635005705 Walker A/P-loop; other site 515635005706 ATP binding site [chemical binding]; other site 515635005707 Q-loop/lid; other site 515635005708 ABC transporter signature motif; other site 515635005709 Walker B; other site 515635005710 D-loop; other site 515635005711 H-loop/switch region; other site 515635005712 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 515635005713 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 515635005714 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 515635005715 Walker A/P-loop; other site 515635005716 ATP binding site [chemical binding]; other site 515635005717 Q-loop/lid; other site 515635005718 ABC transporter signature motif; other site 515635005719 Walker B; other site 515635005720 D-loop; other site 515635005721 H-loop/switch region; other site 515635005722 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 515635005723 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 515635005724 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 515635005725 dimer interface [polypeptide binding]; other site 515635005726 conserved gate region; other site 515635005727 putative PBP binding loops; other site 515635005728 ABC-ATPase subunit interface; other site 515635005729 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 515635005730 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 515635005731 dimer interface [polypeptide binding]; other site 515635005732 conserved gate region; other site 515635005733 putative PBP binding loops; other site 515635005734 ABC-ATPase subunit interface; other site 515635005735 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 515635005736 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 515635005737 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 515635005738 The substrate binding domain of a cellulose-binding protein from Thermotoga maritima contains the type 2 periplasmic binding fold; Region: PBP2_TmCBP_oligosaccharides_like; cd08509 515635005739 substrate binding site [chemical binding]; other site 515635005740 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 515635005741 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 515635005742 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 515635005743 FeS/SAM binding site; other site 515635005744 Iron-sulfur cluster-binding domain; Region: SPASM; pfam13186 515635005745 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 515635005746 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 515635005747 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 515635005748 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 515635005749 Glycosyl hydrolase family 43; Region: GH43_ABN_1; cd08998 515635005750 substrate binding site [chemical binding]; other site 515635005751 active site 515635005752 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 515635005753 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 515635005754 dimer interface [polypeptide binding]; other site 515635005755 conserved gate region; other site 515635005756 putative PBP binding loops; other site 515635005757 ABC-ATPase subunit interface; other site 515635005758 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 515635005759 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 515635005760 dimer interface [polypeptide binding]; other site 515635005761 conserved gate region; other site 515635005762 putative PBP binding loops; other site 515635005763 ABC-ATPase subunit interface; other site 515635005764 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 515635005765 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 515635005766 L-fucose isomerase and related proteins [Carbohydrate transport and metabolism]; Region: FucI; COG2407 515635005767 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 515635005768 hexamer (dimer of trimers) interface [polypeptide binding]; other site 515635005769 trimer interface [polypeptide binding]; other site 515635005770 substrate binding site [chemical binding]; other site 515635005771 Mn binding site [ion binding]; other site 515635005772 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 515635005773 intersubunit interface [polypeptide binding]; other site 515635005774 active site 515635005775 Zn2+ binding site [ion binding]; other site 515635005776 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 515635005777 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 515635005778 Transcriptional regulators [Transcription]; Region: PurR; COG1609 515635005779 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 515635005780 DNA binding site [nucleotide binding] 515635005781 domain linker motif; other site 515635005782 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 515635005783 ligand binding site [chemical binding]; other site 515635005784 dimerization interface [polypeptide binding]; other site 515635005785 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 515635005786 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 515635005787 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 515635005788 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 515635005789 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; cl01412 515635005790 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 515635005791 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 515635005792 putative metal binding site [ion binding]; other site 515635005793 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 515635005794 putative metal binding site [ion binding]; other site 515635005795 Carbohydrate Binding Module family 35 (CBM35); appended mainly to enzymes that bind alpha-D-galactose (CBM35-Gal), including glycoside hydrolase (GH) families GH31 and GH43; Region: CBM35_galactosidase-like; cd04081 515635005796 Ca binding site [ion binding]; other site 515635005797 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 515635005798 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 515635005799 dimer interface [polypeptide binding]; other site 515635005800 conserved gate region; other site 515635005801 putative PBP binding loops; other site 515635005802 ABC-ATPase subunit interface; other site 515635005803 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 515635005804 dimer interface [polypeptide binding]; other site 515635005805 conserved gate region; other site 515635005806 putative PBP binding loops; other site 515635005807 ABC-ATPase subunit interface; other site 515635005808 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 515635005809 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 515635005810 Transcriptional regulators [Transcription]; Region: PurR; COG1609 515635005811 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 515635005812 DNA binding site [nucleotide binding] 515635005813 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 515635005814 dimerization interface [polypeptide binding]; other site 515635005815 ligand binding site [chemical binding]; other site 515635005816 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 515635005817 Benzoyl-CoA reductase/2-hydroxyglutaryl-CoA dehydratase subunit, BcrC/BadD/HgdB [Amino acid transport and metabolism]; Region: HgdB; COG1775 515635005818 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 515635005819 Benzoyl-CoA reductase/2-hydroxyglutaryl-CoA dehydratase subunit, BcrC/BadD/HgdB [Amino acid transport and metabolism]; Region: HgdB; COG1775 515635005820 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 515635005821 ribulokinase; Provisional; Region: PRK04123 515635005822 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 515635005823 N- and C-terminal domain interface [polypeptide binding]; other site 515635005824 active site 515635005825 MgATP binding site [chemical binding]; other site 515635005826 catalytic site [active] 515635005827 metal binding site [ion binding]; metal-binding site 515635005828 carbohydrate binding site [chemical binding]; other site 515635005829 homodimer interface [polypeptide binding]; other site 515635005830 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 515635005831 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 515635005832 NAD binding site [chemical binding]; other site 515635005833 sugar binding site [chemical binding]; other site 515635005834 divalent metal binding site [ion binding]; other site 515635005835 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 515635005836 dimer interface [polypeptide binding]; other site 515635005837 Membrane transport protein; Region: Mem_trans; cl09117 515635005838 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 515635005839 active site 515635005840 NAD binding site [chemical binding]; other site 515635005841 metal binding site [ion binding]; metal-binding site 515635005842 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 515635005843 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 515635005844 ligand binding site [chemical binding]; other site 515635005845 dimerization interface [polypeptide binding]; other site 515635005846 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 515635005847 metal binding site [ion binding]; metal-binding site 515635005848 active site 515635005849 I-site; other site 515635005850 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 515635005851 dimerization interface [polypeptide binding]; other site 515635005852 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 515635005853 ligand binding site [chemical binding]; other site 515635005854 GAF domain; Region: GAF_3; pfam13492 515635005855 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 515635005856 metal binding site [ion binding]; metal-binding site 515635005857 active site 515635005858 I-site; other site 515635005859 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 515635005860 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 515635005861 Zn2+ binding site [ion binding]; other site 515635005862 Mg2+ binding site [ion binding]; other site 515635005863 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 515635005864 dimer interface [polypeptide binding]; other site 515635005865 active site 515635005866 metal binding site [ion binding]; metal-binding site 515635005867 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 515635005868 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 515635005869 substrate binding site [chemical binding]; other site 515635005870 THF binding site; other site 515635005871 zinc-binding site [ion binding]; other site 515635005872 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 515635005873 substrate binding site [chemical binding]; other site 515635005874 THF binding site; other site 515635005875 zinc-binding site [ion binding]; other site 515635005876 N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789 515635005877 active site 515635005878 alpha-mannosidase; Provisional; Region: PRK09819 515635005879 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 515635005880 Glycosyl hydrolases family 38 C-terminal domain; Region: Glyco_hydro_38C; pfam07748 515635005881 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 515635005882 metal binding site [ion binding]; metal-binding site 515635005883 active site 515635005884 I-site; other site 515635005885 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 515635005886 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 515635005887 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 515635005888 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 515635005889 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 515635005890 Major Facilitator Superfamily; Region: MFS_1; pfam07690 515635005891 putative substrate translocation pore; other site 515635005892 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 515635005893 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 515635005894 Walker A/P-loop; other site 515635005895 ATP binding site [chemical binding]; other site 515635005896 Q-loop/lid; other site 515635005897 ABC transporter signature motif; other site 515635005898 Walker B; other site 515635005899 D-loop; other site 515635005900 H-loop/switch region; other site 515635005901 Cobalt transport protein; Region: CbiQ; cl00463 515635005902 PDGLE domain; Region: PDGLE; pfam13190 515635005903 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; cl00397 515635005904 nickel responsive regulator; Provisional; Region: PRK04460 515635005905 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 515635005906 NikR C terminal nickel binding domain; Region: NikR_C; pfam08753 515635005907 ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606 515635005908 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 515635005909 Ligand Binding Site [chemical binding]; other site 515635005910 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 515635005911 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 515635005912 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 515635005913 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 515635005914 classical (c) SDRs; Region: SDR_c; cd05233 515635005915 NAD(P) binding site [chemical binding]; other site 515635005916 active site 515635005917 DctM-like transporters; Region: DctM; pfam06808 515635005918 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 515635005919 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 515635005920 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 515635005921 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_2; cd12172 515635005922 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 515635005923 putative ligand binding site [chemical binding]; other site 515635005924 putative NAD binding site [chemical binding]; other site 515635005925 catalytic site [active] 515635005926 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 515635005927 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 515635005928 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 515635005929 putative active site [active] 515635005930 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 515635005931 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 515635005932 Bacterial protein of unknown function (DUF876); Region: DUF876; cl01406 515635005933 Repressor of nif and glnA expression [Transcription]; Region: COG1693 515635005934 Ribonuclease R winged-helix domain; Region: HTH_12; pfam08461 515635005935 Domain of unknown function DUF128; Region: DUF128; pfam01995 515635005936 argininosuccinate lyase; Provisional; Region: PRK00855 515635005937 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 515635005938 active sites [active] 515635005939 tetramer interface [polypeptide binding]; other site 515635005940 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 515635005941 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 515635005942 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 515635005943 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; smart01096 515635005944 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 515635005945 ATP-grasp domain; Region: ATP-grasp_4; cl17255 515635005946 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 515635005947 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 515635005948 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 515635005949 catalytic site [active] 515635005950 subunit interface [polypeptide binding]; other site 515635005951 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 515635005952 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 515635005953 inhibitor-cofactor binding pocket; inhibition site 515635005954 pyridoxal 5'-phosphate binding site [chemical binding]; other site 515635005955 catalytic residue [active] 515635005956 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 515635005957 heterotetramer interface [polypeptide binding]; other site 515635005958 active site pocket [active] 515635005959 cleavage site 515635005960 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 515635005961 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; pfam01118 515635005962 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl19935 515635005963 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 515635005964 ANP binding site [chemical binding]; other site 515635005965 Substrate Binding Site II [chemical binding]; other site 515635005966 Substrate Binding Site I [chemical binding]; other site 515635005967 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 515635005968 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 515635005969 phosphopeptide binding site; other site 515635005970 CHASE2 domain; Region: CHASE2; pfam05226 515635005971 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 515635005972 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 515635005973 active site 515635005974 ATP binding site [chemical binding]; other site 515635005975 substrate binding site [chemical binding]; other site 515635005976 activation loop (A-loop); other site 515635005977 ornithine carbamoyltransferase; Provisional; Region: PRK00779 515635005978 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 515635005979 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 515635005980 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 515635005981 Major Facilitator Superfamily; Region: MFS_1; pfam07690 515635005982 putative substrate translocation pore; other site 515635005983 Predicted permeases [General function prediction only]; Region: COG0679 515635005984 Protein of unknown function (DUF401); Region: DUF401; cl00830 515635005985 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 515635005986 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 515635005987 active site 515635005988 metal binding site [ion binding]; metal-binding site 515635005989 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 515635005990 pyruvate kinase; Provisional; Region: PRK06354 515635005991 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 515635005992 domain interfaces; other site 515635005993 active site 515635005994 PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; cl17700 515635005995 Septum formation initiator; Region: DivIC; cl17659 515635005996 putative DNA modification/repair radical SAM protein; Region: rSAM_link_UDG; TIGR03916 515635005997 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 515635005998 FeS/SAM binding site; other site 515635005999 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 515635006000 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 515635006001 beta-galactosidase; Region: BGL; TIGR03356 515635006002 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 515635006003 active site 515635006004 Peptidase family M54, also called archaemetzincins or archaelysins; Region: Peptidase_M54; cd11375 515635006005 active site 515635006006 Zn binding site [ion binding]; other site 515635006007 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 515635006008 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 515635006009 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 515635006010 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 515635006011 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 515635006012 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 515635006013 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 515635006014 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 515635006015 dimer interface [polypeptide binding]; other site 515635006016 conserved gate region; other site 515635006017 putative PBP binding loops; other site 515635006018 ABC-ATPase subunit interface; other site 515635006019 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 515635006020 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 515635006021 dimer interface [polypeptide binding]; other site 515635006022 conserved gate region; other site 515635006023 putative PBP binding loops; other site 515635006024 ABC-ATPase subunit interface; other site 515635006025 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 515635006026 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 515635006027 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 515635006028 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 515635006029 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 515635006030 nucleotide binding site [chemical binding]; other site 515635006031 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 515635006032 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 515635006033 active site 515635006034 catalytic tetrad [active] 515635006035 Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293 515635006036 Domain of unknown function (DUF814); Region: DUF814; pfam05670 515635006037 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 515635006038 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 515635006039 RNA binding surface [nucleotide binding]; other site 515635006040 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 515635006041 active site 515635006042 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 515635006043 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 515635006044 ligand binding site [chemical binding]; other site 515635006045 flexible hinge region; other site 515635006046 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 515635006047 putative switch regulator; other site 515635006048 non-specific DNA interactions [nucleotide binding]; other site 515635006049 DNA binding site [nucleotide binding] 515635006050 sequence specific DNA binding site [nucleotide binding]; other site 515635006051 putative cAMP binding site [chemical binding]; other site