-- dump date   	20140619_065657
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
398580000001	dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749
398580000002	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
398580000003	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
398580000004	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
398580000005	active site
398580000006	dimer interface [polypeptide binding]; other site
398580000007	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
398580000008	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
398580000009	active site
398580000010	FMN binding site [chemical binding]; other site
398580000011	substrate binding site [chemical binding]; other site
398580000012	3Fe-4S cluster binding site [ion binding]; other site
398580000013	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
398580000014	domain interface; other site
398580000015	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
398580000016	2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830
398580000017	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
398580000018	trimer interface [polypeptide binding]; other site
398580000019	active site
398580000020	substrate binding site [chemical binding]; other site
398580000021	CoA binding site [chemical binding]; other site
398580000022	cysteinyl-tRNA synthetase; Region: cysS; TIGR00435
398580000023	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
398580000024	DNA-binding site [nucleotide binding]; DNA binding site
398580000025	RNA-binding motif; other site
398580000026	Domain of unknown function (DUF305); Region: DUF305; cl17794
398580000027	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009
398580000028	M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891
398580000029	metal binding site [ion binding]; metal-binding site
398580000030	dimer interface [polypeptide binding]; other site
398580000031	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
398580000032	transferase 1, rSAM/selenodomain-associated; Region: glyco_like_cofC; TIGR04282
398580000033	ribonuclease R; Region: RNase_R; TIGR02063
398580000034	RNB domain; Region: RNB; pfam00773
398580000035	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
398580000036	RNA binding site [nucleotide binding]; other site
398580000037	Transglycosylase SLT domain; Region: SLT_2; pfam13406
398580000038	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
398580000039	N-acetyl-D-glucosamine binding site [chemical binding]; other site
398580000040	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
398580000041	Protein of unknown function (DUF998); Region: DUF998; pfam06197
398580000042	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
398580000043	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
398580000044	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
398580000045	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
398580000046	G1 box; other site
398580000047	putative GEF interaction site [polypeptide binding]; other site
398580000048	GTP/Mg2+ binding site [chemical binding]; other site
398580000049	Switch I region; other site
398580000050	G2 box; other site
398580000051	G3 box; other site
398580000052	Switch II region; other site
398580000053	G4 box; other site
398580000054	G5 box; other site
398580000055	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
398580000056	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
398580000057	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355
398580000058	DNA binding site [nucleotide binding]
398580000059	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
398580000060	RNA/DNA hybrid binding site [nucleotide binding]; other site
398580000061	active site
398580000062	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
398580000063	DNA methylase; Region: N6_N4_Mtase; pfam01555
398580000064	Transcriptional activator [Transcription]; Region: ChrR; COG3806
398580000065	ChrR Cupin-like domain; Region: Cupin_7; pfam12973
398580000066	ChrR Cupin-like domain; Region: Cupin_7; pfam12973
398580000067	biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244
398580000068	NADH(P)-binding; Region: NAD_binding_10; pfam13460
398580000069	NAD binding site [chemical binding]; other site
398580000070	substrate binding site [chemical binding]; other site
398580000071	putative active site [active]
398580000072	Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512
398580000073	Fatty acid desaturase; Region: FA_desaturase; pfam00487
398580000074	Di-iron ligands [ion binding]; other site
398580000075	A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
398580000076	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
398580000077	minor groove reading motif; other site
398580000078	helix-hairpin-helix signature motif; other site
398580000079	substrate binding pocket [chemical binding]; other site
398580000080	active site
398580000081	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576
398580000082	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
398580000083	DNA binding and oxoG recognition site [nucleotide binding]
398580000084	Protein of unknown function (DUF721); Region: DUF721; pfam05258
398580000085	Thioredoxin; Region: Thioredoxin_4; pfam13462
398580000086	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
398580000087	Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; pfam02606
398580000088	3-deoxy-D-manno-octulosonic-acid transferase [Cell envelope biogenesis, outer membrane]; Region: KdtA; COG1519
398580000089	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
398580000090	Uncharacterized conserved protein [Function unknown]; Region: COG2835
398580000091	Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802
398580000092	Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118
398580000093	ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956
398580000094	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
398580000095	putative catalytic site [active]
398580000096	putative metal binding site [ion binding]; other site
398580000097	putative phosphate binding site [ion binding]; other site
398580000098	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
398580000099	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
398580000100	active site
398580000101	phosphorylation site [posttranslational modification]
398580000102	intermolecular recognition site; other site
398580000103	dimerization interface [polypeptide binding]; other site
398580000104	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
398580000105	DNA binding site [nucleotide binding]
398580000106	GTP cyclohydrolase; Provisional; Region: PRK08815
398580000107	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
398580000108	dimerization interface [polypeptide binding]; other site
398580000109	active site
398580000110	Protein of unknown function (DUF1330); Region: DUF1330; cl02288
398580000111	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786
398580000112	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
398580000113	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
398580000114	catalytic residue [active]
398580000115	Gram-negative porin; Region: Porin_4; pfam13609
398580000116	Domain of unknown function (DUF3576); Region: DUF3576; pfam12100
398580000117	Protein of unknown function (DUF3478); Region: DUF3478; pfam11964
398580000118	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
398580000119	putative DNA binding site [nucleotide binding]; other site
398580000120	putative Zn2+ binding site [ion binding]; other site
398580000121	Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760
398580000122	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
398580000123	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762
398580000124	Domain of unknown function (DUF955); Region: DUF955; pfam06114
398580000125	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
398580000126	uncharacterized flavoprotein, PP_4765 family; Region: flavo_PP4765; TIGR03862
398580000127	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
398580000128	GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046
398580000129	putative C-terminal domain interface [polypeptide binding]; other site
398580000130	putative GSH binding site (G-site) [chemical binding]; other site
398580000131	putative dimer interface [polypeptide binding]; other site
398580000132	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
398580000133	dimer interface [polypeptide binding]; other site
398580000134	N-terminal domain interface [polypeptide binding]; other site
398580000135	substrate binding pocket (H-site) [chemical binding]; other site
398580000136	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK06585
398580000137	Lipopolysaccharide-assembly; Region: LptE; pfam04390
398580000138	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
398580000139	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
398580000140	HIGH motif; other site
398580000141	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
398580000142	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
398580000143	active site
398580000144	KMSKS motif; other site
398580000145	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
398580000146	tRNA binding surface [nucleotide binding]; other site
398580000147	Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834
398580000148	Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548
398580000149	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
398580000150	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
398580000151	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
398580000152	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
398580000153	succinyldiaminopimelate transaminase; Provisional; Region: PRK09147
398580000154	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
398580000155	pyridoxal 5'-phosphate binding site [chemical binding]; other site
398580000156	homodimer interface [polypeptide binding]; other site
398580000157	catalytic residue [active]
398580000158	hypothetical protein; Provisional; Region: PRK06102
398580000159	Amidase; Region: Amidase; cl11426
398580000160	2-octaprenyl-6-methoxyphenyl hydroxylase; Provisional; Region: PRK07333
398580000161	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
398580000162	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
398580000163	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
398580000164	active site
398580000165	peptidase PmbA; Provisional; Region: PRK11040
398580000166	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
398580000167	classical (c) SDRs; Region: SDR_c; cd05233
398580000168	NAD(P) binding site [chemical binding]; other site
398580000169	active site
398580000170	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
398580000171	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
398580000172	substrate binding site [chemical binding]; other site
398580000173	oxyanion hole (OAH) forming residues; other site
398580000174	trimer interface [polypeptide binding]; other site
398580000175	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
398580000176	N-acetyl-D-glucosamine binding site [chemical binding]; other site
398580000177	catalytic residue [active]
398580000178	Predicted permeases [General function prediction only]; Region: COG0679
398580000179	Hemimethylated DNA-binding protein YccV like; Region: YccV-like; pfam08755
398580000180	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
398580000181	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
398580000182	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
398580000183	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
398580000184	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
398580000185	anti sigma factor interaction site; other site
398580000186	regulatory phosphorylation site [posttranslational modification]; other site
398580000187	acetyl-CoA acetyltransferase; Provisional; Region: PRK06954
398580000188	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
398580000189	dimer interface [polypeptide binding]; other site
398580000190	active site
398580000191	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
398580000192	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
398580000193	putative acyl-acceptor binding pocket; other site
398580000194	EamA-like transporter family; Region: EamA; pfam00892
398580000195	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
398580000196	tartrate dehydrogenase; Region: TTC; TIGR02089
398580000197	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
398580000198	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
398580000199	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
398580000200	substrate binding site [chemical binding]; other site
398580000201	Short repeat of unknown function (DUF308); Region: DUF308; cl15828
398580000202	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
398580000203	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
398580000204	substrate binding site [chemical binding]; other site
398580000205	ligand binding site [chemical binding]; other site
398580000206	SOUL heme-binding protein; Region: SOUL; pfam04832
398580000207	iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090
398580000208	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
398580000209	phosphoglyceromutase; Provisional; Region: PRK05434
398580000210	Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696
398580000211	Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942
398580000212	Peptidase family M23; Region: Peptidase_M23; pfam01551
398580000213	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
398580000214	C-terminal peptidase (prc); Region: prc; TIGR00225
398580000215	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
398580000216	protein binding site [polypeptide binding]; other site
398580000217	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
398580000218	Catalytic dyad [active]
398580000219	Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671
398580000220	putative active site [active]
398580000221	Ap4A binding site [chemical binding]; other site
398580000222	nudix motif; other site
398580000223	putative metal binding site [ion binding]; other site
398580000224	Mu-like prophage I protein; Region: Mu-like_Pro; pfam10123
398580000225	Mu-like prophage major head subunit gpT; Region: Mu-like_gpT; pfam10124
398580000226	Homeodomain-like domain; Region: HTH_23; pfam13384
398580000227	Protein of unknown function (DUF1018); Region: DUF1018; pfam06252
398580000228	AAA domain; Region: AAA_22; pfam13401
398580000229	Mu B transposition protein, C terminal; Region: Phage-MuB_C; pfam09077
398580000230	Mu DNA binding, I gamma subdomain; Region: HTH_Tnp_Mu_2; pfam09039
398580000231	Bacteriophage Mu transposase; Region: DDE_2; pfam02914
398580000232	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434
398580000233	putative active site [active]
398580000234	DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481
398580000235	putative PHP Thumb interface [polypeptide binding]; other site
398580000236	Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733
398580000237	Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062
398580000238	class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300
398580000239	substrate binding site [chemical binding]; other site
398580000240	catalytic Zn binding site [ion binding]; other site
398580000241	NAD binding site [chemical binding]; other site
398580000242	structural Zn binding site [ion binding]; other site
398580000243	dimer interface [polypeptide binding]; other site
398580000244	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
398580000245	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
398580000246	Uncharacterized subfamily of N-terminal LabA-like domains; Region: LabA_like_N_1; cd11297
398580000247	putative metal binding site [ion binding]; other site
398580000248	Uncharacterized conserved protein [Function unknown]; Region: COG1432
398580000249	C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146
398580000250	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
398580000251	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
398580000252	AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246
398580000253	Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045
398580000254	diiron binding motif [ion binding]; other site
398580000255	Uncharacterized conserved protein [Function unknown]; Region: COG1633
398580000256	CCC1-related protein family; Region: CCC1_like_1; cd02437
398580000257	Predicted permeases [General function prediction only]; Region: COG0679
398580000258	Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; pfam02639
398580000259	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
398580000260	Major Facilitator Superfamily; Region: MFS_1; pfam07690
398580000261	putative substrate translocation pore; other site
398580000262	Predicted ATPase [General function prediction only]; Region: COG1485
398580000263	Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013
398580000264	catalytic triad [active]
398580000265	dimer interface [polypeptide binding]; other site
398580000266	phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754
398580000267	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
398580000268	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
398580000269	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
398580000270	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
398580000271	S-adenosylmethionine binding site [chemical binding]; other site
398580000272	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
398580000273	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
398580000274	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
398580000275	active site
398580000276	putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347
398580000277	Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058
398580000278	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
398580000279	putative MPT binding site; other site
398580000280	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
398580000281	uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926
398580000282	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
398580000283	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
398580000284	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
398580000285	ligand binding site [chemical binding]; other site
398580000286	Transcriptional regulator [Transcription]; Region: LysR; COG0583
398580000287	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
398580000288	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
398580000289	putative effector binding pocket; other site
398580000290	dimerization interface [polypeptide binding]; other site
398580000291	A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134
398580000292	intracellular protease, PfpI family; Region: PfpI; TIGR01382
398580000293	proposed catalytic triad [active]
398580000294	conserved cys residue [active]
398580000295	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
398580000296	2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli  is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930
398580000297	active site
398580000298	FMN binding site [chemical binding]; other site
398580000299	2,4-decadienoyl-CoA binding site; other site
398580000300	catalytic residue [active]
398580000301	4Fe-4S cluster binding site [ion binding]; other site
398580000302	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
398580000303	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
398580000304	Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196
398580000305	ATP binding site [chemical binding]; other site
398580000306	substrate interface [chemical binding]; other site
398580000307	dihydroxy-acid dehydratase; Provisional; Region: PRK00911
398580000308	CAAX protease self-immunity; Region: Abi; pfam02517
398580000309	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
398580000310	RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717
398580000311	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
398580000312	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
398580000313	Hint domain; Region: Hint_2; pfam13403
398580000314	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_b; cd00914
398580000315	aromatic arch; other site
398580000316	DCoH dimer interaction site [polypeptide binding]; other site
398580000317	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
398580000318	DCoH tetramer interaction site [polypeptide binding]; other site
398580000319	substrate binding site [chemical binding]; other site
398580000320	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497
398580000321	Protein of unknown function, DUF482; Region: DUF482; pfam04339
398580000322	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
398580000323	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
398580000324	active site
398580000325	catalytic site [active]
398580000326	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199
398580000327	homotrimer interaction site [polypeptide binding]; other site
398580000328	putative active site [active]
398580000329	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
398580000330	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
398580000331	HlyD family secretion protein; Region: HlyD_3; pfam13437
398580000332	ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618
398580000333	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
398580000334	ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246
398580000335	Walker A/P-loop; other site
398580000336	ATP binding site [chemical binding]; other site
398580000337	Q-loop/lid; other site
398580000338	ABC transporter signature motif; other site
398580000339	Walker B; other site
398580000340	D-loop; other site
398580000341	H-loop/switch region; other site
398580000342	VacJ like lipoprotein; Region: VacJ; cl01073
398580000343	Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494
398580000344	Transglycosylase; Region: Transgly; pfam00912
398580000345	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
398580000346	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
398580000347	Nitrogen regulatory protein P-II; Region: P-II; pfam00543
398580000348	Nitrogen regulatory protein P-II; Region: P-II; smart00938
398580000349	probable ammonium transporter, marine subtype; Region: marine_trans_1; TIGR03644
398580000350	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
398580000351	aromatic amino acid aminotransferase; Provisional; Region: PRK09257
398580000352	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
398580000353	catalytic residue [active]
398580000354	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
398580000355	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
398580000356	active site residue [active]
398580000357	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
398580000358	active site residue [active]
398580000359	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
398580000360	SmpB-tmRNA interface; other site
398580000361	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
398580000362	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
398580000363	Coenzyme A binding pocket [chemical binding]; other site
398580000364	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
398580000365	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
398580000366	dimer interface [polypeptide binding]; other site
398580000367	active site
398580000368	catalytic residue [active]
398580000369	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
398580000370	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
398580000371	N-acetyl-D-glucosamine binding site [chemical binding]; other site
398580000372	catalytic residue [active]
398580000373	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
398580000374	Uncharacterized conserved protein [Function unknown]; Region: COG4121
398580000375	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
398580000376	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
398580000377	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
398580000378	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
398580000379	LrgA family; Region: LrgA; pfam03788
398580000380	LrgB-like family; Region: LrgB; pfam04172
398580000381	ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109
398580000382	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561
398580000383	homodimer interface [polypeptide binding]; other site
398580000384	Walker A motif; other site
398580000385	ATP binding site [chemical binding]; other site
398580000386	hydroxycobalamin binding site [chemical binding]; other site
398580000387	Walker B motif; other site
398580000388	cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989
398580000389	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
398580000390	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
398580000391	cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475
398580000392	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
398580000393	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
398580000394	Probable cobalt transporter subunit (CbtA); Region: CbtA; pfam09490
398580000395	Probable cobalt transporter subunit (CbtB); Region: CbtB; pfam09489
398580000396	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
398580000397	AAA domain; Region: AAA_23; pfam13476
398580000398	Walker A/P-loop; other site
398580000399	ATP binding site [chemical binding]; other site
398580000400	Q-loop/lid; other site
398580000401	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
398580000402	ABC transporter signature motif; other site
398580000403	Walker B; other site
398580000404	D-loop; other site
398580000405	H-loop/switch region; other site
398580000406	lytic murein transglycosylase; Region: MltB_2; TIGR02283
398580000407	murein hydrolase B; Provisional; Region: PRK10760; cl17906
398580000408	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
398580000409	CobD/Cbib protein; Region: CobD_Cbib; pfam03186
398580000410	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
398580000411	L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140
398580000412	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
398580000413	catalytic residue [active]
398580000414	Protein of unknown function (DUF1636); Region: DUF1636; pfam07845
398580000415	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
398580000416	active site
398580000417	phosphorylation site [posttranslational modification]
398580000418	intermolecular recognition site; other site
398580000419	dimerization interface [polypeptide binding]; other site
398580000420	Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435
398580000421	Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409
398580000422	C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190
398580000423	putative dimer interface [polypeptide binding]; other site
398580000424	N-terminal domain interface [polypeptide binding]; other site
398580000425	putative substrate binding pocket (H-site) [chemical binding]; other site
398580000426	Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138
398580000427	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
398580000428	putative active site [active]
398580000429	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414
398580000430	putative active site [active]
398580000431	putative molybdopterin-guanine dinucleotide biosynthesis protein MobB/unknown domain fusion protein; Provisional; Region: PRK14495
398580000432	precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285
398580000433	Precorrin-8X methylmutase; Region: CbiC; pfam02570
398580000434	Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644
398580000435	active site
398580000436	putative homodimer interface [polypeptide binding]; other site
398580000437	SAM binding site [chemical binding]; other site
398580000438	Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242
398580000439	precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; Region: CbiT; TIGR02469
398580000440	Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645
398580000441	active site
398580000442	SAM binding site [chemical binding]; other site
398580000443	homodimer interface [polypeptide binding]; other site
398580000444	Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760
398580000445	Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761
398580000446	Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890
398580000447	Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646
398580000448	active site
398580000449	SAM binding site [chemical binding]; other site
398580000450	homodimer interface [polypeptide binding]; other site
398580000451	Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641
398580000452	active site
398580000453	SAM binding site [chemical binding]; other site
398580000454	homodimer interface [polypeptide binding]; other site
398580000455	Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168
398580000456	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
398580000457	pyridoxal 5'-phosphate binding site [chemical binding]; other site
398580000458	homodimer interface [polypeptide binding]; other site
398580000459	catalytic residue [active]
398580000460	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
398580000461	active site
398580000462	catalytic residues [active]
398580000463	metal binding site [ion binding]; metal-binding site
398580000464	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
398580000465	active site
398580000466	catalytic residues [active]
398580000467	metal binding site [ion binding]; metal-binding site
398580000468	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
398580000469	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
398580000470	putative active site [active]
398580000471	substrate binding site [chemical binding]; other site
398580000472	putative cosubstrate binding site; other site
398580000473	catalytic site [active]
398580000474	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
398580000475	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
398580000476	RNA/DNA hybrid binding site [nucleotide binding]; other site
398580000477	active site
398580000478	Methyltransferase domain; Region: Methyltransf_23; pfam13489
398580000479	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
398580000480	S-adenosylmethionine binding site [chemical binding]; other site
398580000481	Protein of unknown function (DUF3429); Region: DUF3429; pfam11911
398580000482	Predicted CDP-diglyceride synthetase/phosphatidate cytidylyltransferase [General function prediction only]; Region: COG4589
398580000483	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
398580000484	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
398580000485	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
398580000486	putative acyl-acceptor binding pocket; other site
398580000487	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
398580000488	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
398580000489	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
398580000490	Cytochrome c; Region: Cytochrom_C; pfam00034
398580000491	Predicted membrane protein [Function unknown]; Region: COG1238
398580000492	Uncharacterized conserved protein [Function unknown]; Region: COG1432
398580000493	LabA_like proteins; Region: LabA; cd10911
398580000494	putative metal binding site [ion binding]; other site
398580000495	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
398580000496	catalytic center binding site [active]
398580000497	ATP binding site [chemical binding]; other site
398580000498	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
398580000499	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
398580000500	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
398580000501	Zn2+ binding site [ion binding]; other site
398580000502	Mg2+ binding site [ion binding]; other site
398580000503	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
398580000504	synthetase active site [active]
398580000505	NTP binding site [chemical binding]; other site
398580000506	metal binding site [ion binding]; metal-binding site
398580000507	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
398580000508	ACT domain; Region: ACT_4; pfam13291
398580000509	Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; pfam09835
398580000510	Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003
398580000511	active site
398580000512	hydrophilic channel; other site
398580000513	dimerization interface [polypeptide binding]; other site
398580000514	catalytic residues [active]
398580000515	active site lid [active]
398580000516	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
398580000517	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
398580000518	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
398580000519	Catalytic site [active]
398580000520	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
398580000521	ribonuclease III, bacterial; Region: RNaseIII; TIGR02191
398580000522	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
398580000523	dimerization interface [polypeptide binding]; other site
398580000524	active site
398580000525	metal binding site [ion binding]; metal-binding site
398580000526	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
398580000527	dsRNA binding site [nucleotide binding]; other site
398580000528	GTPase Era; Reviewed; Region: era; PRK00089
398580000529	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
398580000530	G1 box; other site
398580000531	GTP/Mg2+ binding site [chemical binding]; other site
398580000532	Switch I region; other site
398580000533	G2 box; other site
398580000534	Switch II region; other site
398580000535	G3 box; other site
398580000536	G4 box; other site
398580000537	G5 box; other site
398580000538	KH domain; Region: KH_2; pfam07650
398580000539	Protein of unknown function (DUF1491); Region: DUF1491; pfam07372
398580000540	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
398580000541	Recombination protein O N terminal; Region: RecO_N; pfam11967
398580000542	Recombination protein O C terminal; Region: RecO_C; pfam02565
398580000543	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
398580000544	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
398580000545	active site
398580000546	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
398580000547	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ACT14924; Region: LPLAT_ACT14924-like; cd07986
398580000548	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
398580000549	putative acyl-acceptor binding pocket; other site
398580000550	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
398580000551	dimerization domain swap beta strand [polypeptide binding]; other site
398580000552	regulatory protein interface [polypeptide binding]; other site
398580000553	active site
398580000554	regulatory phosphorylation site [posttranslational modification]; other site
398580000555	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025
398580000556	active pocket/dimerization site; other site
398580000557	active site
398580000558	phosphorylation site [posttranslational modification]
398580000559	glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
398580000560	shikimate kinase; Reviewed; Region: aroK; PRK00131
398580000561	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270
398580000562	metal-binding site [ion binding]
398580000563	Sensor N-terminal transmembrane domain; Region: Sensor_TM1; pfam13755
398580000564	Stimulus-sensing domain; Region: Stimulus_sens_1; pfam13756
398580000565	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
398580000566	HAMP domain; Region: HAMP; pfam00672
398580000567	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
398580000568	dimer interface [polypeptide binding]; other site
398580000569	phosphorylation site [posttranslational modification]
398580000570	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
398580000571	ATP binding site [chemical binding]; other site
398580000572	Mg2+ binding site [ion binding]; other site
398580000573	G-X-G motif; other site
398580000574	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
398580000575	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
398580000576	active site
398580000577	phosphorylation site [posttranslational modification]
398580000578	intermolecular recognition site; other site
398580000579	dimerization interface [polypeptide binding]; other site
398580000580	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
398580000581	DNA binding site [nucleotide binding]
398580000582	Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293
398580000583	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484
398580000584	active site
398580000585	substrate-binding site [chemical binding]; other site
398580000586	metal-binding site [ion binding]
398580000587	ATP binding site [chemical binding]; other site
398580000588	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07530
398580000589	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
398580000590	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
398580000591	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
398580000592	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
398580000593	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
398580000594	Ligand binding site [chemical binding]; other site
398580000595	Electron transfer flavoprotein domain; Region: ETF; pfam01012
398580000596	Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923
398580000597	Hypoxia induced protein conserved region; Region: HIG_1_N; pfam04588
398580000598	short chain dehydrogenase; Provisional; Region: PRK05993
398580000599	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
398580000600	NADP binding site [chemical binding]; other site
398580000601	active site
398580000602	steroid binding site; other site
398580000603	DNA topoisomerase IV subunit A; Validated; Region: PRK05561
398580000604	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
398580000605	CAP-like domain; other site
398580000606	active site
398580000607	elongation factor Tu; Reviewed; Region: PRK00049
398580000608	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
398580000609	G1 box; other site
398580000610	GEF interaction site [polypeptide binding]; other site
398580000611	GTP/Mg2+ binding site [chemical binding]; other site
398580000612	Switch I region; other site
398580000613	G2 box; other site
398580000614	G3 box; other site
398580000615	Switch II region; other site
398580000616	G4 box; other site
398580000617	G5 box; other site
398580000618	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
398580000619	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
398580000620	Antibiotic Binding Site [chemical binding]; other site
398580000621	Hexameric tyrosine-coordinated heme protein (HTHP); Region: HTHP; pfam11534
398580000622	Protein of unknown function (DUF1244); Region: DUF1244; pfam06844
398580000623	N-formylglutamate amidohydrolase; Region: FGase; cl01522
398580000624	pyruvate kinase; Provisional; Region: PRK06247
398580000625	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
398580000626	domain interfaces; other site
398580000627	active site
398580000628	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
398580000629	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
398580000630	23S rRNA binding site [nucleotide binding]; other site
398580000631	L21 binding site [polypeptide binding]; other site
398580000632	L13 binding site [polypeptide binding]; other site
398580000633	Hint domain; Region: Hint_2; pfam13403
398580000634	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
398580000635	transmembrane helices; other site
398580000636	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
398580000637	TrkA-C domain; Region: TrkA_C; pfam02080
398580000638	TrkA-C domain; Region: TrkA_C; pfam02080
398580000639	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
398580000640	Hint domain; Region: Hint_2; pfam13403
398580000641	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
398580000642	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
398580000643	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
398580000644	dimer interface [polypeptide binding]; other site
398580000645	motif 1; other site
398580000646	active site
398580000647	motif 2; other site
398580000648	motif 3; other site
398580000649	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
398580000650	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
398580000651	putative tRNA-binding site [nucleotide binding]; other site
398580000652	B3/4 domain; Region: B3_4; pfam03483
398580000653	tRNA synthetase B5 domain; Region: B5; smart00874
398580000654	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
398580000655	dimer interface [polypeptide binding]; other site
398580000656	motif 1; other site
398580000657	motif 3; other site
398580000658	motif 2; other site
398580000659	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896
398580000660	Protein of unknown function (DUF2872); Region: DUF2872; pfam11071
398580000661	L-aspartate dehydrogenase; Provisional; Region: PRK13303
398580000662	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
398580000663	Domain of unknown function DUF108; Region: DUF108; pfam01958
398580000664	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
398580000665	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
398580000666	C-terminal domain interface [polypeptide binding]; other site
398580000667	GSH binding site (G-site) [chemical binding]; other site
398580000668	dimer interface [polypeptide binding]; other site
398580000669	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
398580000670	N-terminal domain interface [polypeptide binding]; other site
398580000671	dimer interface [polypeptide binding]; other site
398580000672	substrate binding pocket (H-site) [chemical binding]; other site
398580000673	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
398580000674	large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952
398580000675	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
398580000676	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
398580000677	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
398580000678	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
398580000679	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
398580000680	hexamer interface [polypeptide binding]; other site
398580000681	ligand binding site [chemical binding]; other site
398580000682	putative active site [active]
398580000683	NAD(P) binding site [chemical binding]; other site
398580000684	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
398580000685	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
398580000686	putative DNA binding site [nucleotide binding]; other site
398580000687	putative Zn2+ binding site [ion binding]; other site
398580000688	AsnC family; Region: AsnC_trans_reg; pfam01037
398580000689	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
398580000690	rpsU-divergently transcribed protein; Region: diverge_rpsU; TIGR02396
398580000691	COQ9; Region: COQ9; pfam08511
398580000692	putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824
398580000693	PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276
398580000694	NAD(P) binding site [chemical binding]; other site
398580000695	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
398580000696	Protein export membrane protein; Region: SecD_SecF; cl14618
398580000697	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
398580000698	HlyD family secretion protein; Region: HlyD_3; pfam13437
398580000699	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
398580000700	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
398580000701	WHG domain; Region: WHG; pfam13305
398580000702	4-coumarate--CoA ligase; Region: PLN02246
398580000703	4-Coumarate-CoA Ligase (4CL); Region: 4CL; cd05904
398580000704	acyl-activating enzyme (AAE) consensus motif; other site
398580000705	active site
398580000706	putative CoA binding site [chemical binding]; other site
398580000707	AMP binding site [chemical binding]; other site
398580000708	Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far.  This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases).  Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062
398580000709	B1 nucleotide binding pocket [chemical binding]; other site
398580000710	B2 nucleotide binding pocket [chemical binding]; other site
398580000711	CAS motifs; other site
398580000712	active site
398580000713	Protein of unknown function (DUF1013); Region: DUF1013; pfam06242
398580000714	Peptidase S8 family domain, uncharacterized subfamily 12; Region: Peptidases_S8_12; cd07480
398580000715	active site
398580000716	catalytic triad [active]
398580000717	SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584
398580000718	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
398580000719	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
398580000720	putative homodimer interface [polypeptide binding]; other site
398580000721	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
398580000722	heterodimer interface [polypeptide binding]; other site
398580000723	homodimer interface [polypeptide binding]; other site
398580000724	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
398580000725	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
398580000726	23S rRNA interface [nucleotide binding]; other site
398580000727	L7/L12 interface [polypeptide binding]; other site
398580000728	putative thiostrepton binding site; other site
398580000729	L25 interface [polypeptide binding]; other site
398580000730	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
398580000731	mRNA/rRNA interface [nucleotide binding]; other site
398580000732	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
398580000733	Hint domain; Region: Hint_2; pfam13403
398580000734	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
398580000735	23S rRNA interface [nucleotide binding]; other site
398580000736	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
398580000737	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
398580000738	core dimer interface [polypeptide binding]; other site
398580000739	peripheral dimer interface [polypeptide binding]; other site
398580000740	L10 interface [polypeptide binding]; other site
398580000741	L11 interface [polypeptide binding]; other site
398580000742	putative EF-Tu interaction site [polypeptide binding]; other site
398580000743	putative EF-G interaction site [polypeptide binding]; other site
398580000744	PPIC-type PPIASE domain; Region: Rotamase_2; cl08278
398580000745	1,4-dihydroxy-2-naphthoate octaprenyltransferase [Coenzyme metabolism]; Region: MenA; cl17224
398580000746	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
398580000747	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
398580000748	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
398580000749	RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562
398580000750	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
398580000751	RPB3 interaction site [polypeptide binding]; other site
398580000752	RPB1 interaction site [polypeptide binding]; other site
398580000753	RPB11 interaction site [polypeptide binding]; other site
398580000754	RPB10 interaction site [polypeptide binding]; other site
398580000755	DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086
398580000756	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
398580000757	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
398580000758	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
398580000759	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
398580000760	RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998
398580000761	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
398580000762	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
398580000763	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
398580000764	Ribosomal L27 protein; Region: Ribosomal_L27; cl00359
398580000765	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
398580000766	DNA binding site [nucleotide binding]
398580000767	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
398580000768	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
398580000769	EamA-like transporter family; Region: EamA; cl17759
398580000770	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
398580000771	S17 interaction site [polypeptide binding]; other site
398580000772	S8 interaction site; other site
398580000773	16S rRNA interaction site [nucleotide binding]; other site
398580000774	streptomycin interaction site [chemical binding]; other site
398580000775	23S rRNA interaction site [nucleotide binding]; other site
398580000776	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
398580000777	30S ribosomal protein S7; Validated; Region: PRK05302
398580000778	elongation factor G; Reviewed; Region: PRK00007
398580000779	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
398580000780	G1 box; other site
398580000781	putative GEF interaction site [polypeptide binding]; other site
398580000782	GTP/Mg2+ binding site [chemical binding]; other site
398580000783	Switch I region; other site
398580000784	G2 box; other site
398580000785	G3 box; other site
398580000786	Switch II region; other site
398580000787	G4 box; other site
398580000788	G5 box; other site
398580000789	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
398580000790	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
398580000791	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
398580000792	elongation factor Tu; Reviewed; Region: PRK00049
398580000793	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
398580000794	G1 box; other site
398580000795	GEF interaction site [polypeptide binding]; other site
398580000796	GTP/Mg2+ binding site [chemical binding]; other site
398580000797	Switch I region; other site
398580000798	G2 box; other site
398580000799	G3 box; other site
398580000800	Switch II region; other site
398580000801	G4 box; other site
398580000802	G5 box; other site
398580000803	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
398580000804	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
398580000805	Antibiotic Binding Site [chemical binding]; other site
398580000806	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
398580000807	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
398580000808	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
398580000809	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
398580000810	Protein of unknown function (DUF433); Region: DUF433; pfam04255
398580000811	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
398580000812	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
398580000813	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
398580000814	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
398580000815	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
398580000816	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
398580000817	putative translocon binding site; other site
398580000818	protein-rRNA interface [nucleotide binding]; other site
398580000819	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
398580000820	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
398580000821	G-X-X-G motif; other site
398580000822	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
398580000823	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
398580000824	23S rRNA interface [nucleotide binding]; other site
398580000825	5S rRNA interface [nucleotide binding]; other site
398580000826	putative antibiotic binding site [chemical binding]; other site
398580000827	L25 interface [polypeptide binding]; other site
398580000828	L27 interface [polypeptide binding]; other site
398580000829	Domain of unknown function (DUF4149); Region: DUF4149; pfam13664
398580000830	Putative 2OG-Fe(II) oxygenase; Region: 2OG-FeII_Oxy_5; cl17879
398580000831	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
398580000832	23S rRNA interface [nucleotide binding]; other site
398580000833	putative translocon interaction site; other site
398580000834	signal recognition particle (SRP54) interaction site; other site
398580000835	L23 interface [polypeptide binding]; other site
398580000836	trigger factor interaction site; other site
398580000837	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
398580000838	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
398580000839	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
398580000840	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
398580000841	RNA binding site [nucleotide binding]; other site
398580000842	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
398580000843	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
398580000844	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
398580000845	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
398580000846	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
398580000847	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
398580000848	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
398580000849	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
398580000850	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
398580000851	5S rRNA interface [nucleotide binding]; other site
398580000852	23S rRNA interface [nucleotide binding]; other site
398580000853	L5 interface [polypeptide binding]; other site
398580000854	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
398580000855	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
398580000856	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
398580000857	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
398580000858	23S rRNA binding site [nucleotide binding]; other site
398580000859	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
398580000860	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
398580000861	SecY translocase; Region: SecY; pfam00344
398580000862	adenylate kinase; Reviewed; Region: adk; PRK00279
398580000863	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
398580000864	AMP-binding site [chemical binding]; other site
398580000865	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
398580000866	Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099
398580000867	30S ribosomal protein S13; Region: bact_S13; TIGR03631
398580000868	30S ribosomal protein S11; Validated; Region: PRK05309
398580000869	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
398580000870	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
398580000871	alphaNTD - beta interaction site [polypeptide binding]; other site
398580000872	alphaNTD homodimer interface [polypeptide binding]; other site
398580000873	alphaNTD - beta' interaction site [polypeptide binding]; other site
398580000874	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
398580000875	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
398580000876	Autoinducer binding domain; Region: Autoind_bind; pfam03472
398580000877	helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421
398580000878	DNA binding residues [nucleotide binding]
398580000879	dimerization interface [polypeptide binding]; other site
398580000880	Autoinducer synthetase; Region: Autoind_synth; cl17404
398580000881	recombination factor protein RarA; Reviewed; Region: PRK13342
398580000882	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
398580000883	Walker A motif; other site
398580000884	ATP binding site [chemical binding]; other site
398580000885	Walker B motif; other site
398580000886	arginine finger; other site
398580000887	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
398580000888	CrcB-like protein; Region: CRCB; cl09114
398580000889	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
398580000890	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
398580000891	RNA binding surface [nucleotide binding]; other site
398580000892	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
398580000893	active site
398580000894	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
398580000895	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
398580000896	motif II; other site
398580000897	ATP12 chaperone protein; Region: ATP12; cl02228
398580000898	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
398580000899	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
398580000900	substrate binding pocket [chemical binding]; other site
398580000901	membrane-bound complex binding site; other site
398580000902	hinge residues; other site
398580000903	ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597
398580000904	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
398580000905	conserved gate region; other site
398580000906	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
398580000907	dimer interface [polypeptide binding]; other site
398580000908	conserved gate region; other site
398580000909	putative PBP binding loops; other site
398580000910	ABC-ATPase subunit interface; other site
398580000911	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
398580000912	dimer interface [polypeptide binding]; other site
398580000913	conserved gate region; other site
398580000914	putative PBP binding loops; other site
398580000915	ABC-ATPase subunit interface; other site
398580000916	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
398580000917	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
398580000918	Walker A/P-loop; other site
398580000919	ATP binding site [chemical binding]; other site
398580000920	Q-loop/lid; other site
398580000921	ABC transporter signature motif; other site
398580000922	Walker B; other site
398580000923	D-loop; other site
398580000924	H-loop/switch region; other site
398580000925	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
398580000926	catalytic core [active]
398580000927	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
398580000928	feedback inhibition sensing region; other site
398580000929	homohexameric interface [polypeptide binding]; other site
398580000930	nucleotide binding site [chemical binding]; other site
398580000931	N-acetyl-L-glutamate binding site [chemical binding]; other site
398580000932	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
398580000933	classical (c) SDRs; Region: SDR_c; cd05233
398580000934	NAD(P) binding site [chemical binding]; other site
398580000935	active site
398580000936	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
398580000937	Elongation factor Tu GTP binding domain; Region: GTP_EFTU; pfam00009
398580000938	G1 box; other site
398580000939	GTP/Mg2+ binding site [chemical binding]; other site
398580000940	Switch I region; other site
398580000941	G2 box; other site
398580000942	G3 box; other site
398580000943	Switch II region; other site
398580000944	G4 box; other site
398580000945	G5 box; other site
398580000946	MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476
398580000947	Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217
398580000948	MOSC domain; Region: MOSC; pfam03473
398580000949	membrane protein insertase; Provisional; Region: PRK01318
398580000950	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
398580000951	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
398580000952	metal binding site [ion binding]; metal-binding site
398580000953	active site
398580000954	I-site; other site
398580000955	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
398580000956	tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696
398580000957	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_II; cd01993
398580000958	Ligand Binding Site [chemical binding]; other site
398580000959	Haemolytic domain; Region: Haemolytic; pfam01809
398580000960	Ribonuclease P; Region: Ribonuclease_P; cl00457
398580000961	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399
398580000962	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
398580000963	His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512
398580000964	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
398580000965	ATP binding site [chemical binding]; other site
398580000966	Mg2+ binding site [ion binding]; other site
398580000967	G-X-G motif; other site
398580000968	mercuric reductase; Validated; Region: PRK06370
398580000969	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
398580000970	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
398580000971	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
398580000972	ATPase MipZ; Region: MipZ; pfam09140
398580000973	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
398580000974	P-loop; other site
398580000975	Magnesium ion binding site [ion binding]; other site
398580000976	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
398580000977	Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853
398580000978	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00528
398580000979	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
398580000980	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
398580000981	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
398580000982	active site
398580000983	substrate binding site [chemical binding]; other site
398580000984	ATP binding site [chemical binding]; other site
398580000985	Phosphotransferase enzyme family; Region: APH; pfam01636
398580000986	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK13828
398580000987	RimM N-terminal domain; Region: RimM; pfam01782
398580000988	PRC-barrel domain; Region: PRC; pfam05239
398580000989	EVE domain; Region: EVE; cl00728
398580000990	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
398580000991	FMN binding site [chemical binding]; other site
398580000992	dimer interface [polypeptide binding]; other site
398580000993	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
398580000994	chorismate mutase; Provisional; Region: PRK09239
398580000995	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
398580000996	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
398580000997	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
398580000998	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
398580000999	signal recognition particle protein; Provisional; Region: PRK10867
398580001000	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
398580001001	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
398580001002	Signal peptide binding domain; Region: SRP_SPB; pfam02978
398580001003	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
398580001004	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
398580001005	Transcriptional regulator [Transcription]; Region: LysR; COG0583
398580001006	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
398580001007	LysR substrate binding domain; Region: LysR_substrate; pfam03466
398580001008	dimerization interface [polypeptide binding]; other site
398580001009	EamA-like transporter family; Region: EamA; pfam00892
398580001010	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
398580001011	dimerization interface [polypeptide binding]; other site
398580001012	putative DNA binding site [nucleotide binding]; other site
398580001013	putative Zn2+ binding site [ion binding]; other site
398580001014	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
398580001015	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
398580001016	purine monophosphate binding site [chemical binding]; other site
398580001017	dimer interface [polypeptide binding]; other site
398580001018	putative catalytic residues [active]
398580001019	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
398580001020	lipoprotein signal peptidase; Provisional; Region: PRK14782
398580001021	lipoprotein signal peptidase; Provisional; Region: PRK14787
398580001022	Protein of unknown function (DUF3035); Region: DUF3035; pfam11233
398580001023	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
398580001024	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
398580001025	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
398580001026	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
398580001027	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
398580001028	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
398580001029	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
398580001030	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
398580001031	ATP binding site [chemical binding]; other site
398580001032	Mg2+ binding site [ion binding]; other site
398580001033	G-X-G motif; other site
398580001034	MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL.  EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family.  This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482
398580001035	ATP binding site [chemical binding]; other site
398580001036	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
398580001037	RmuC family; Region: RmuC; pfam02646
398580001038	anti-sigma factor, putative, ChrR family; Region: anti_sig_ChrR; TIGR02451
398580001039	ChrR Cupin-like domain; Region: Cupin_7; pfam12973
398580001040	RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652
398580001041	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
398580001042	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
398580001043	DNA binding residues [nucleotide binding]
398580001044	Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907
398580001045	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
398580001046	Protein of unknown function (DUF1365); Region: DUF1365; pfam07103
398580001047	MFS/sugar transport protein; Region: MFS_2; pfam13347
398580001048	melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392
398580001049	Protein of unknown function (DUF3833); Region: DUF3833; pfam12915
398580001050	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
398580001051	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
398580001052	NAD(P) binding site [chemical binding]; other site
398580001053	active site
398580001054	Protein of unknown function (DUF3775); Region: DUF3775; pfam12616
398580001055	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
398580001056	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
398580001057	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
398580001058	acyl-activating enzyme (AAE) consensus motif; other site
398580001059	putative AMP binding site [chemical binding]; other site
398580001060	putative active site [active]
398580001061	putative CoA binding site [chemical binding]; other site
398580001062	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
398580001063	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
398580001064	Walker A/P-loop; other site
398580001065	ATP binding site [chemical binding]; other site
398580001066	Q-loop/lid; other site
398580001067	ABC transporter signature motif; other site
398580001068	Walker B; other site
398580001069	D-loop; other site
398580001070	H-loop/switch region; other site
398580001071	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
398580001072	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
398580001073	TM-ABC transporter signature motif; other site
398580001074	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
398580001075	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
398580001076	TM-ABC transporter signature motif; other site
398580001077	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_1; cd06334
398580001078	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
398580001079	putative ligand binding site [chemical binding]; other site
398580001080	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
398580001081	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
398580001082	Walker A/P-loop; other site
398580001083	ATP binding site [chemical binding]; other site
398580001084	Q-loop/lid; other site
398580001085	ABC transporter signature motif; other site
398580001086	Walker B; other site
398580001087	D-loop; other site
398580001088	H-loop/switch region; other site
398580001089	Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541
398580001090	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
398580001091	acyl-activating enzyme (AAE) consensus motif; other site
398580001092	active site
398580001093	AMP binding site [chemical binding]; other site
398580001094	CoA binding site [chemical binding]; other site
398580001095	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
398580001096	nudix motif; other site
398580001097	DNA polymerase IV; Provisional; Region: PRK02794
398580001098	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
398580001099	active site
398580001100	DNA binding site [nucleotide binding]
398580001101	N-formylglutamate amidohydrolase; Region: FGase; pfam05013
398580001102	50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831
398580001103	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
398580001104	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
398580001105	Walker A/P-loop; other site
398580001106	ATP binding site [chemical binding]; other site
398580001107	Q-loop/lid; other site
398580001108	ABC transporter signature motif; other site
398580001109	Walker B; other site
398580001110	D-loop; other site
398580001111	H-loop/switch region; other site
398580001112	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
398580001113	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
398580001114	TM-ABC transporter signature motif; other site
398580001115	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
398580001116	Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
398580001117	ligand binding site [chemical binding]; other site
398580001118	Protein of unknown function (DUF4238); Region: DUF4238; pfam14022
398580001119	SEC-C motif; Region: SEC-C; pfam02810
398580001120	Replication initiation factor; Region: Rep_trans; pfam02486
398580001121	Helix-turn-helix domain; Region: HTH_17; pfam12728
398580001122	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
398580001123	Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974
398580001124	active site
398580001125	Int/Topo IB signature motif; other site
398580001126	DNA binding site [nucleotide binding]
398580001127	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
398580001128	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
398580001129	catalytic residues [active]
398580001130	catalytic nucleophile [active]
398580001131	Recombinase; Region: Recombinase; pfam07508
398580001132	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
398580001133	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
398580001134	active site
398580001135	Int/Topo IB signature motif; other site
398580001136	DNA binding site [nucleotide binding]
398580001137	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
398580001138	DNA binding site [nucleotide binding]
398580001139	active site
398580001140	Int/Topo IB signature motif; other site
398580001141	Helix-turn-helix domain; Region: HTH_17; pfam12728
398580001142	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083
398580001143	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083
398580001144	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656
398580001145	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09638
398580001146	Transposase; Region: HTH_Tnp_1; pfam01527
398580001147	HTH-like domain; Region: HTH_21; pfam13276
398580001148	Integrase core domain; Region: rve; pfam00665
398580001149	Integrase core domain; Region: rve_3; pfam13683
398580001150	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
398580001151	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
398580001152	non-specific DNA binding site [nucleotide binding]; other site
398580001153	salt bridge; other site
398580001154	sequence-specific DNA binding site [nucleotide binding]; other site
398580001155	Domain of unknown function (DUF955); Region: DUF955; pfam06114
398580001156	Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335
398580001157	Fasciclin domain; Region: Fasciclin; pfam02469
398580001158	Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335
398580001159	Fasciclin domain; Region: Fasciclin; pfam02469
398580001160	AAA domain; Region: AAA_14; pfam13173
398580001161	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373
398580001162	nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753
398580001163	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
398580001164	Domain of unknown function (DUF1127); Region: DUF1127; pfam06568
398580001165	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
398580001166	Ligand Binding Site [chemical binding]; other site
398580001167	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
398580001168	Ligand Binding Site [chemical binding]; other site
398580001169	putative MFS family transporter protein; Provisional; Region: PRK03633
398580001170	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
398580001171	putative substrate translocation pore; other site
398580001172	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
398580001173	putative catalytic site [active]
398580001174	putative metal binding site [ion binding]; other site
398580001175	putative phosphate binding site [ion binding]; other site
398580001176	Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111
398580001177	PLD-like domain; Region: PLDc_2; pfam13091
398580001178	putative active site [active]
398580001179	catalytic site [active]
398580001180	Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113
398580001181	PLD-like domain; Region: PLDc_2; pfam13091
398580001182	putative active site [active]
398580001183	catalytic site [active]
398580001184	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
398580001185	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
398580001186	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
398580001187	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
398580001188	active site
398580001189	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
398580001190	Peptidase family M41; Region: Peptidase_M41; pfam01434
398580001191	MerR HTH family regulatory protein; Region: MerR_2; pfam13591
398580001192	Protein of unknown function (DUF2892); Region: DUF2892; pfam11127
398580001193	Poly-beta-hydroxybutyrate polymerase N terminal; Region: PHBC_N; pfam12551
398580001194	poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838
398580001195	Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167
398580001196	B-cell receptor-associated protein 31-like; Region: Bap31; cl02219
398580001197	Predicted membrane protein [Function unknown]; Region: COG1288
398580001198	C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606
398580001199	arginine deiminase; Provisional; Region: PRK01388
398580001200	ornithine carbamoyltransferase; Validated; Region: PRK02102
398580001201	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
398580001202	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
398580001203	carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454
398580001204	AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235
398580001205	putative substrate binding site [chemical binding]; other site
398580001206	homodimer interface [polypeptide binding]; other site
398580001207	nucleotide binding site [chemical binding]; other site
398580001208	nucleotide binding site [chemical binding]; other site
398580001209	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
398580001210	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
398580001211	alpha subunit interaction interface [polypeptide binding]; other site
398580001212	Walker A motif; other site
398580001213	ATP binding site [chemical binding]; other site
398580001214	Walker B motif; other site
398580001215	inhibitor binding site; inhibition site
398580001216	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
398580001217	F0F1 ATP synthase subunit epsilon; Validated; Region: PRK06228
398580001218	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
398580001219	gamma subunit interface [polypeptide binding]; other site
398580001220	epsilon subunit interface [polypeptide binding]; other site
398580001221	LBP interface [polypeptide binding]; other site
398580001222	Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; cl09754
398580001223	ATP synthase A chain; Region: ATP-synt_A; cl00413
398580001224	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
398580001225	F0F1 ATP synthase subunit C; Provisional; Region: PRK13468
398580001226	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
398580001227	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
398580001228	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
398580001229	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
398580001230	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
398580001231	Walker A motif; other site
398580001232	ATP binding site [chemical binding]; other site
398580001233	Walker B motif; other site
398580001234	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
398580001235	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
398580001236	core domain interface [polypeptide binding]; other site
398580001237	delta subunit interface [polypeptide binding]; other site
398580001238	epsilon subunit interface [polypeptide binding]; other site
398580001239	FOG: CBS domain [General function prediction only]; Region: COG0517
398580001240	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622
398580001241	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
398580001242	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
398580001243	ligand binding site [chemical binding]; other site
398580001244	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
398580001245	putative switch regulator; other site
398580001246	non-specific DNA interactions [nucleotide binding]; other site
398580001247	DNA binding site [nucleotide binding]
398580001248	sequence specific DNA binding site [nucleotide binding]; other site
398580001249	putative cAMP binding site [chemical binding]; other site
398580001250	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
398580001251	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
398580001252	dimerization interface [polypeptide binding]; other site
398580001253	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
398580001254	dimer interface [polypeptide binding]; other site
398580001255	phosphorylation site [posttranslational modification]
398580001256	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
398580001257	ATP binding site [chemical binding]; other site
398580001258	Mg2+ binding site [ion binding]; other site
398580001259	G-X-G motif; other site
398580001260	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
398580001261	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
398580001262	active site
398580001263	phosphorylation site [posttranslational modification]
398580001264	intermolecular recognition site; other site
398580001265	dimerization interface [polypeptide binding]; other site
398580001266	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
398580001267	DNA binding site [nucleotide binding]
398580001268	coenzyme PQQ synthesis protein PqqA; Provisional; Region: pqqA; PRK00284
398580001269	pyrroloquinoline quinone biosynthesis protein PqqB; Provisional; Region: PRK05184
398580001270	coenzyme PQQ biosynthesis protein B; Region: PQQ_syn_pqqB; TIGR02108
398580001271	pyrroloquinoline quinone biosynthesis protein PqqC; Provisional; Region: PRK05157
398580001272	Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; pfam05402
398580001273	pyrroloquinoline quinone biosynthesis protein PqqE; Provisional; Region: PRK05301
398580001274	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
398580001275	FeS/SAM binding site; other site
398580001276	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
398580001277	MoxR-like ATPases [General function prediction only]; Region: COG0714
398580001278	ATPase family associated with various cellular activities (AAA); Region: AAA_3; pfam07726
398580001279	Walker A motif; other site
398580001280	ATP binding site [chemical binding]; other site
398580001281	Walker B motif; other site
398580001282	arginine finger; other site
398580001283	Protein of unknown function DUF58; Region: DUF58; pfam01882
398580001284	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
398580001285	metal ion-dependent adhesion site (MIDAS); other site
398580001286	von Willebrand factor type A domain; Region: VWA_2; pfam13519
398580001287	Oxygen tolerance; Region: BatD; pfam13584
398580001288	Transposase; Region: HTH_Tnp_1; pfam01527
398580001289	putative transposase OrfB; Reviewed; Region: PHA02517
398580001290	HTH-like domain; Region: HTH_21; pfam13276
398580001291	Integrase core domain; Region: rve; pfam00665
398580001292	Integrase core domain; Region: rve_3; pfam13683
398580001293	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
398580001294	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
398580001295	active site
398580001296	phosphorylation site [posttranslational modification]
398580001297	intermolecular recognition site; other site
398580001298	dimerization interface [polypeptide binding]; other site
398580001299	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
398580001300	DNA binding residues [nucleotide binding]
398580001301	dimerization interface [polypeptide binding]; other site
398580001302	FIST N domain; Region: FIST; pfam08495
398580001303	Uncharacterized conserved protein [Function unknown]; Region: COG3287
398580001304	FIST C domain; Region: FIST_C; pfam10442
398580001305	PAS fold; Region: PAS_7; pfam12860
398580001306	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
398580001307	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
398580001308	dimer interface [polypeptide binding]; other site
398580001309	phosphorylation site [posttranslational modification]
398580001310	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
398580001311	ATP binding site [chemical binding]; other site
398580001312	Mg2+ binding site [ion binding]; other site
398580001313	G-X-G motif; other site
398580001314	Response regulator receiver domain; Region: Response_reg; pfam00072
398580001315	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
398580001316	active site
398580001317	phosphorylation site [posttranslational modification]
398580001318	intermolecular recognition site; other site
398580001319	dimerization interface [polypeptide binding]; other site
398580001320	Sulfur oxidation protein SoxY; Region: SoxY; pfam13501
398580001321	Sulphur oxidation protein SoxZ; Region: SoxZ; pfam08770
398580001322	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
398580001323	Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062
398580001324	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
398580001325	NAD(P) binding site [chemical binding]; other site
398580001326	S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821
398580001327	S-formylglutathione hydrolase; Region: PLN02442
398580001328	Cytochrome c; Region: Cytochrom_C; cl11414
398580001329	PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075
398580001330	Large subunit of methanol dehydrogenase (moxF); Region: PQQ_MDH; cd10278
398580001331	Trp docking motif [polypeptide binding]; other site
398580001332	dimer interface [polypeptide binding]; other site
398580001333	active site
398580001334	small subunit binding site [polypeptide binding]; other site
398580001335	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
398580001336	c-type cytochrome, methanol metabolism-related; Region: 4cys_cytochr; TIGR03874
398580001337	quinoprotein dehydrogenase-associated probable ABC transporter substrate-binding protein; Region: ABC_peri_MoxJ_2; TIGR03871
398580001338	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
398580001339	substrate binding pocket [chemical binding]; other site
398580001340	membrane-bound complex binding site; other site
398580001341	hinge residues; other site
398580001342	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
398580001343	active site residue [active]
398580001344	Sulfur oxidation protein SoxY; Region: SoxY; pfam13501
398580001345	Sulphur oxidation protein SoxZ; Region: SoxZ; pfam08770
398580001346	Protein of unknown function (DUF2380); Region: DUF3280; pfam11684
398580001347	Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268
398580001348	ligand binding site [chemical binding]; other site
398580001349	PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866
398580001350	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
398580001351	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
398580001352	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
398580001353	Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670
398580001354	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
398580001355	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832
398580001356	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
398580001357	substrate binding pocket [chemical binding]; other site
398580001358	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
398580001359	membrane-bound complex binding site; other site
398580001360	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
398580001361	ABC-type taurine transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG4525
398580001362	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
398580001363	Walker A/P-loop; other site
398580001364	ATP binding site [chemical binding]; other site
398580001365	Q-loop/lid; other site
398580001366	ABC transporter signature motif; other site
398580001367	Walker B; other site
398580001368	D-loop; other site
398580001369	H-loop/switch region; other site
398580001370	NnrS protein; Region: NnrS; pfam05940
398580001371	TonB-dependent Receptor Plug Domain; Region: Plug; cl08461
398580001372	4Fe-4S binding domain; Region: Fer4; pfam00037
398580001373	4Fe-4S dicluster domain; Region: Fer4_10; pfam13237
398580001374	Protein of unknown function (DUF3305); Region: DUF3305; pfam11749
398580001375	Protein of unknown function (DUF3306); Region: DUF3306; pfam11748
398580001376	Nitrate reductase delta subunit; Region: Nitrate_red_del; pfam02613
398580001377	Formylmethanofuran dehydrogenase subunit B [Energy production and conversion]; Region: FwdB; COG1029
398580001378	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752
398580001379	[4Fe-4S] binding site [ion binding]; other site
398580001380	molybdopterin cofactor binding site; other site
398580001381	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
398580001382	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792
398580001383	molybdopterin cofactor binding site; other site
398580001384	DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951
398580001385	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
398580001386	formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583
398580001387	Domain of unknown function DUF59; Region: DUF59; cl00941
398580001388	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
398580001389	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
398580001390	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
398580001391	FOG: WD40 repeat [General function prediction only]; Region: COG2319
398580001392	structural tetrad; other site
398580001393	Cytochrome c; Region: Cytochrom_C; cl11414
398580001394	Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015
398580001395	Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015
398580001396	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
398580001397	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
398580001398	DNA binding residues [nucleotide binding]
398580001399	dimerization interface [polypeptide binding]; other site
398580001400	Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566
398580001401	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
398580001402	dimer interface [polypeptide binding]; other site
398580001403	phosphorylation site [posttranslational modification]
398580001404	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
398580001405	ATP binding site [chemical binding]; other site
398580001406	Mg2+ binding site [ion binding]; other site
398580001407	G-X-G motif; other site
398580001408	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
398580001409	Methylthioribose-binding protein-like of ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_methylthioribose_binding_like; cd06305
398580001410	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
398580001411	putative ligand binding site [chemical binding]; other site
398580001412	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
398580001413	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
398580001414	TM-ABC transporter signature motif; other site
398580001415	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
398580001416	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
398580001417	Walker A/P-loop; other site
398580001418	ATP binding site [chemical binding]; other site
398580001419	Q-loop/lid; other site
398580001420	ABC transporter signature motif; other site
398580001421	Walker B; other site
398580001422	D-loop; other site
398580001423	H-loop/switch region; other site
398580001424	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
398580001425	methylthioribose kinase; Reviewed; Region: mtnK; PRK09550
398580001426	Phosphotransferase enzyme family; Region: APH; pfam01636
398580001427	methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720
398580001428	S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512
398580001429	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
398580001430	MarR family; Region: MarR_2; cl17246
398580001431	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
398580001432	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214
398580001433	intersubunit interface [polypeptide binding]; other site
398580001434	active site
398580001435	Zn2+ binding site [ion binding]; other site
398580001436	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
398580001437	active site
398580001438	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
398580001439	catalytic tetrad [active]
398580001440	Predicted ATPase [General function prediction only]; Region: COG3911
398580001441	AAA domain; Region: AAA_28; pfam13521
398580001442	DAK2 domain; Region: Dak2; pfam02734
398580001443	dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557
398580001444	Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376
398580001445	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
398580001446	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
398580001447	TM-ABC transporter signature motif; other site
398580001448	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
398580001449	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
398580001450	TM-ABC transporter signature motif; other site
398580001451	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
398580001452	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
398580001453	Walker A/P-loop; other site
398580001454	ATP binding site [chemical binding]; other site
398580001455	Q-loop/lid; other site
398580001456	ABC transporter signature motif; other site
398580001457	Walker B; other site
398580001458	D-loop; other site
398580001459	H-loop/switch region; other site
398580001460	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
398580001461	Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302
398580001462	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
398580001463	ligand binding site [chemical binding]; other site
398580001464	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
398580001465	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257
398580001466	DNA binding residues [nucleotide binding]
398580001467	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
398580001468	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
398580001469	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
398580001470	DNA interaction; other site
398580001471	Metal-binding active site; metal-binding site
398580001472	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182
398580001473	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
398580001474	tetramer interface [polypeptide binding]; other site
398580001475	TPP-binding site [chemical binding]; other site
398580001476	heterodimer interface [polypeptide binding]; other site
398580001477	phosphorylation loop region [posttranslational modification]
398580001478	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
398580001479	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
398580001480	alpha subunit interface [polypeptide binding]; other site
398580001481	TPP binding site [chemical binding]; other site
398580001482	heterodimer interface [polypeptide binding]; other site
398580001483	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
398580001484	acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional; Region: PRK14875
398580001485	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
398580001486	E3 interaction surface; other site
398580001487	lipoyl attachment site [posttranslational modification]; other site
398580001488	e3 binding domain; Region: E3_binding; pfam02817
398580001489	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883
398580001490	nucleophilic elbow; other site
398580001491	catalytic triad; other site
398580001492	Ribulose kinase [Energy production and conversion]; Region: AraB; COG1069
398580001493	Carbohydrate kinase and ribulose-phosphate 3-epimerase fusion proteins-like; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CarbK-RPE_like; cd07783
398580001494	N- and C-terminal domain interface [polypeptide binding]; other site
398580001495	active site
398580001496	MgATP binding site [chemical binding]; other site
398580001497	catalytic site [active]
398580001498	metal binding site [ion binding]; metal-binding site
398580001499	putative carbohydrate binding site [chemical binding]; other site
398580001500	putative homodimer interface [polypeptide binding]; other site
398580001501	putative phosphonate metabolism protein; Region: Phn_opern_protn; TIGR03223
398580001502	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
398580001503	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
398580001504	active site
398580001505	catalytic tetrad [active]
398580001506	NnrU protein; Region: NnrU; pfam07298
398580001507	coproporphyrinogen III oxidase; Provisional; Region: PRK09249
398580001508	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
398580001509	FeS/SAM binding site; other site
398580001510	HemN C-terminal domain; Region: HemN_C; pfam06969
398580001511	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
398580001512	Phosphate transporter family; Region: PHO4; pfam01384
398580001513	Na/Pi-cotransporter; Region: NaPi_cotrn_rel; TIGR00704
398580001514	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
398580001515	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
398580001516	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
398580001517	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
398580001518	motif II; other site
398580001519	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
398580001520	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
398580001521	Walker A/P-loop; other site
398580001522	ATP binding site [chemical binding]; other site
398580001523	Q-loop/lid; other site
398580001524	ABC transporter signature motif; other site
398580001525	Walker B; other site
398580001526	D-loop; other site
398580001527	H-loop/switch region; other site
398580001528	TOBE domain; Region: TOBE_2; pfam08402
398580001529	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
398580001530	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
398580001531	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
398580001532	dimer interface [polypeptide binding]; other site
398580001533	conserved gate region; other site
398580001534	putative PBP binding loops; other site
398580001535	ABC-ATPase subunit interface; other site
398580001536	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
398580001537	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
398580001538	dimer interface [polypeptide binding]; other site
398580001539	conserved gate region; other site
398580001540	putative PBP binding loops; other site
398580001541	ABC-ATPase subunit interface; other site
398580001542	Sigma-70, region 4; Region: Sigma70_r4; pfam04545
398580001543	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
398580001544	DNA binding residues [nucleotide binding]
398580001545	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
398580001546	L-idonate 5-dehydrogenase; Region: PLN02702
398580001547	Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285
398580001548	inhibitor binding site; inhibition site
398580001549	catalytic Zn binding site [ion binding]; other site
398580001550	structural Zn binding site [ion binding]; other site
398580001551	NADP binding site [chemical binding]; other site
398580001552	tetramer interface [polypeptide binding]; other site
398580001553	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
398580001554	Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005
398580001555	tetramer interface [polypeptide binding]; other site
398580001556	active site
398580001557	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
398580001558	classical (c) SDRs; Region: SDR_c; cd05233
398580001559	NAD(P) binding site [chemical binding]; other site
398580001560	active site
398580001561	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
398580001562	classical (c) SDRs; Region: SDR_c; cd05233
398580001563	NAD(P) binding site [chemical binding]; other site
398580001564	active site
398580001565	Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_YpCarbK_like; cd07782
398580001566	FGGY-family pentulose kinase; Region: 5C_CHO_kinase; TIGR01315
398580001567	N- and C-terminal domain interface [polypeptide binding]; other site
398580001568	active site
398580001569	MgATP binding site [chemical binding]; other site
398580001570	catalytic site [active]
398580001571	metal binding site [ion binding]; metal-binding site
398580001572	carbohydrate binding site [chemical binding]; other site
398580001573	putative homodimer interface [polypeptide binding]; other site
398580001574	nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753
398580001575	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
398580001576	D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711
398580001577	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
398580001578	Protein of unknown function (DUF1636); Region: DUF1636; pfam07845
398580001579	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
398580001580	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
398580001581	Walker A/P-loop; other site
398580001582	ATP binding site [chemical binding]; other site
398580001583	Q-loop/lid; other site
398580001584	ABC transporter signature motif; other site
398580001585	Walker B; other site
398580001586	D-loop; other site
398580001587	H-loop/switch region; other site
398580001588	proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868
398580001589	Metal binding protein TroA_a.  These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148
398580001590	putative ligand binding residues [chemical binding]; other site
398580001591	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
398580001592	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
398580001593	ABC-ATPase subunit  interface; other site
398580001594	dimer interface [polypeptide binding]; other site
398580001595	putative PBP binding regions; other site
398580001596	Imelysin; Region: Peptidase_M75; cl09159
398580001597	Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488
398580001598	Protein of unknown function (DUF1111); Region: DUF1111; pfam06537
398580001599	Imelysin; Region: Peptidase_M75; pfam09375
398580001600	Protein of unknown function (DUF1513); Region: DUF1513; pfam07433
398580001601	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
398580001602	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
398580001603	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
398580001604	N-terminal plug; other site
398580001605	ligand-binding site [chemical binding]; other site
398580001606	hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548
398580001607	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
398580001608	Walker A/P-loop; other site
398580001609	ATP binding site [chemical binding]; other site
398580001610	Q-loop/lid; other site
398580001611	ABC transporter signature motif; other site
398580001612	Walker B; other site
398580001613	D-loop; other site
398580001614	H-loop/switch region; other site
398580001615	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
398580001616	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
398580001617	ABC-ATPase subunit  interface; other site
398580001618	dimer interface [polypeptide binding]; other site
398580001619	putative PBP binding regions; other site
398580001620	Hemin binding protein HutB.  These proteins have been shown to function as initial receptors in ABC transport of hemin and hemoproteins in many eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a...; Region: HutB; cd01149
398580001621	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
398580001622	putative hemin binding site; other site
398580001623	Putative heme degradation protein [Inorganic ion transport and metabolism]; Region: HemS; COG3720
398580001624	Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171
398580001625	Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171
398580001626	Transcriptional regulator [Transcription]; Region: LysR; COG0583
398580001627	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
398580001628	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
398580001629	dimerization interface [polypeptide binding]; other site
398580001630	Bacillus subtilis NADP+-dependent alpha-ketoglutaric semialdehyde dehydrogenase ycbD-like; Region: ALDH_KGSADH-YcbD; cd07097
398580001631	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
398580001632	NAD(P) binding site [chemical binding]; other site
398580001633	catalytic residues [active]
398580001634	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
398580001635	Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355
398580001636	active site
398580001637	BCCT family transporter; Region: BCCT; pfam02028
398580001638	Protein of unknown function (DUF3726); Region: DUF3726; pfam12525
398580001639	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150
398580001640	homotrimer interaction site [polypeptide binding]; other site
398580001641	putative active site [active]
398580001642	2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198
398580001643	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
398580001644	polysaccharide export inner-membrane protein, BexC/CtrB/KpsE family; Region: BexC_CtrB_KpsE; TIGR01010
398580001645	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
398580001646	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
398580001647	Walker A/P-loop; other site
398580001648	ATP binding site [chemical binding]; other site
398580001649	Q-loop/lid; other site
398580001650	ABC transporter signature motif; other site
398580001651	Walker B; other site
398580001652	D-loop; other site
398580001653	H-loop/switch region; other site
398580001654	Predicted permeases [General function prediction only]; Region: COG0701
398580001655	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
398580001656	putative DNA binding site [nucleotide binding]; other site
398580001657	putative Zn2+ binding site [ion binding]; other site
398580001658	Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033
398580001659	putative uracil binding site [chemical binding]; other site
398580001660	putative active site [active]
398580001661	Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164
398580001662	putative ligand binding site [chemical binding]; other site
398580001663	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
398580001664	NAD binding site [chemical binding]; other site
398580001665	dimerization interface [polypeptide binding]; other site
398580001666	catalytic site [active]
398580001667	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
398580001668	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
398580001669	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
398580001670	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
398580001671	rod shape-determining protein MreC; Provisional; Region: PRK13922
398580001672	rod shape-determining protein MreC; Region: MreC; pfam04085
398580001673	rod shape-determining protein MreB; Provisional; Region: PRK13927
398580001674	MreB and similar proteins; Region: MreB_like; cd10225
398580001675	nucleotide binding site [chemical binding]; other site
398580001676	Mg binding site [ion binding]; other site
398580001677	putative protofilament interaction site [polypeptide binding]; other site
398580001678	RodZ interaction site [polypeptide binding]; other site
398580001679	2-isopropylmalate synthase; Validated; Region: PRK00915
398580001680	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
398580001681	active site
398580001682	catalytic residues [active]
398580001683	metal binding site [ion binding]; metal-binding site
398580001684	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
398580001685	Uncharacterized conserved protein [Function unknown]; Region: COG3391
398580001686	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
398580001687	C factor cell-cell signaling protein; Provisional; Region: PRK09009
398580001688	NAD(P) binding site [chemical binding]; other site
398580001689	active site
398580001690	Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046
398580001691	Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244
398580001692	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642
398580001693	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642
398580001694	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642
398580001695	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642
398580001696	NAD synthetase; Provisional; Region: PRK13981
398580001697	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
398580001698	multimer interface [polypeptide binding]; other site
398580001699	active site
398580001700	catalytic triad [active]
398580001701	protein interface 1 [polypeptide binding]; other site
398580001702	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
398580001703	homodimer interface [polypeptide binding]; other site
398580001704	NAD binding pocket [chemical binding]; other site
398580001705	ATP binding pocket [chemical binding]; other site
398580001706	Mg binding site [ion binding]; other site
398580001707	active-site loop [active]
398580001708	Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952
398580001709	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
398580001710	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
398580001711	2-pyrone-4,6-dicarboxylic acid (PDC) hydrolase hydrolyzes PDC to yield 4-oxalomesaconic acid (OMA) or its tautomer, 4-carboxy-2-hydroxymuconic acid (CHM). This reaction is part of the protocatechuate (PCA) 4,5-cleavage pathway. PCA is one of the most...; Region: PDC_hydrolase; cd01311
398580001712	active site
398580001713	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
398580001714	DctM-like transporters; Region: DctM; pfam06808
398580001715	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290
398580001716	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
398580001717	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
398580001718	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
398580001719	DNA-binding site [nucleotide binding]; DNA binding site
398580001720	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
398580001721	pyridoxal 5'-phosphate binding site [chemical binding]; other site
398580001722	homodimer interface [polypeptide binding]; other site
398580001723	catalytic residue [active]
398580001724	hypothetical protein; Provisional; Region: PRK05463
398580001725	NIPSNAP; Region: NIPSNAP; pfam07978
398580001726	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
398580001727	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
398580001728	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
398580001729	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
398580001730	active site
398580001731	dimer interface [polypeptide binding]; other site
398580001732	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
398580001733	Clp amino terminal domain; Region: Clp_N; pfam02861
398580001734	Clp amino terminal domain; Region: Clp_N; pfam02861
398580001735	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
398580001736	Walker A motif; other site
398580001737	ATP binding site [chemical binding]; other site
398580001738	Walker B motif; other site
398580001739	arginine finger; other site
398580001740	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
398580001741	Walker A motif; other site
398580001742	ATP binding site [chemical binding]; other site
398580001743	Walker B motif; other site
398580001744	arginine finger; other site
398580001745	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
398580001746	Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525
398580001747	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
398580001748	classical (c) SDRs; Region: SDR_c; cd05233
398580001749	NAD(P) binding site [chemical binding]; other site
398580001750	active site
398580001751	Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335
398580001752	Fasciclin domain; Region: Fasciclin; pfam02469
398580001753	Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335
398580001754	Fasciclin domain; Region: Fasciclin; pfam02469
398580001755	TMAO/DMSO reductase; Reviewed; Region: PRK05363
398580001756	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
398580001757	Moco binding site; other site
398580001758	metal coordination site [ion binding]; other site
398580001759	putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419
398580001760	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
398580001761	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
398580001762	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
398580001763	Walker A/P-loop; other site
398580001764	ATP binding site [chemical binding]; other site
398580001765	Q-loop/lid; other site
398580001766	ABC transporter signature motif; other site
398580001767	Walker B; other site
398580001768	D-loop; other site
398580001769	H-loop/switch region; other site
398580001770	PBP superfamily domain; Region: PBP_like_2; pfam12849
398580001771	Helix-turn-helix domain; Region: HTH_17; pfam12728
398580001772	PBP superfamily domain; Region: PBP_like; pfam12727
398580001773	glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266
398580001774	hydroxyglutarate oxidase; Provisional; Region: PRK11728
398580001775	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
398580001776	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
398580001777	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
398580001778	Acetate kinase [Energy production and conversion]; Region: ackA; COG0282
398580001779	propionate/acetate kinase; Provisional; Region: PRK12379
398580001780	bifunctional enoyl-CoA hydratase/phosphate acetyltransferase; Validated; Region: PRK08190
398580001781	(R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449
398580001782	dimer interaction site [polypeptide binding]; other site
398580001783	substrate-binding tunnel; other site
398580001784	active site
398580001785	catalytic site [active]
398580001786	substrate binding site [chemical binding]; other site
398580001787	Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212
398580001788	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
398580001789	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
398580001790	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
398580001791	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
398580001792	ligand binding site [chemical binding]; other site
398580001793	flexible hinge region; other site
398580001794	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
398580001795	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
398580001796	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
398580001797	Zn binding site [ion binding]; other site
398580001798	C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347
398580001799	Zn binding site [ion binding]; other site
398580001800	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
398580001801	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
398580001802	Walker A/P-loop; other site
398580001803	ATP binding site [chemical binding]; other site
398580001804	Q-loop/lid; other site
398580001805	ABC transporter signature motif; other site
398580001806	Walker B; other site
398580001807	D-loop; other site
398580001808	H-loop/switch region; other site
398580001809	ABC-2 type transporter; Region: ABC2_membrane; cl17235
398580001810	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
398580001811	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
398580001812	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
398580001813	tandem repeat interface [polypeptide binding]; other site
398580001814	oligomer interface [polypeptide binding]; other site
398580001815	active site residues [active]
398580001816	Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530
398580001817	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
398580001818	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
398580001819	short chain dehydrogenase; Provisional; Region: PRK09134
398580001820	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
398580001821	NAD(P) binding site [chemical binding]; other site
398580001822	active site
398580001823	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
398580001824	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
398580001825	GIY-YIG motif/motif A; other site
398580001826	active site
398580001827	catalytic site [active]
398580001828	putative DNA binding site [nucleotide binding]; other site
398580001829	metal binding site [ion binding]; metal-binding site
398580001830	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
398580001831	TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358
398580001832	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
398580001833	TRAP transporter, 4TM/12TM fusion protein; Region: TRAP_fused; TIGR02123
398580001834	DctM-like transporters; Region: DctM; pfam06808
398580001835	Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525
398580001836	Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318
398580001837	Family description; Region: VCBS; pfam13517
398580001838	recombination protein RecR; Reviewed; Region: recR; PRK00076
398580001839	RecR protein; Region: RecR; pfam02132
398580001840	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
398580001841	putative active site [active]
398580001842	putative metal-binding site [ion binding]; other site
398580001843	tetramer interface [polypeptide binding]; other site
398580001844	hypothetical protein; Validated; Region: PRK00153
398580001845	DNA polymerase III subunits gamma and tau; Validated; Region: PRK09111
398580001846	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
398580001847	Walker A motif; other site
398580001848	ATP binding site [chemical binding]; other site
398580001849	Walker B motif; other site
398580001850	arginine finger; other site
398580001851	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
398580001852	DNA polymerase III gamma and tau subunits C terminal; Region: DUF3646; pfam12362
398580001853	NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]; Region: NPY1; COG2816
398580001854	NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296
398580001855	NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297
398580001856	NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429
398580001857	putative NADH binding site [chemical binding]; other site
398580001858	putative active site [active]
398580001859	nudix motif; other site
398580001860	putative metal binding site [ion binding]; other site
398580001861	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812
398580001862	hydrophobic ligand binding site; other site
398580001863	prephenate dehydratase; Provisional; Region: PRK11899
398580001864	Prephenate dehydratase; Region: PDT; pfam00800
398580001865	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
398580001866	putative L-Phe binding site [chemical binding]; other site
398580001867	Cytochrome c2 [Energy production and conversion]; Region: COG3474
398580001868	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
398580001869	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497
398580001870	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174
398580001871	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
398580001872	dimer interface [polypeptide binding]; other site
398580001873	conserved gate region; other site
398580001874	putative PBP binding loops; other site
398580001875	ABC-ATPase subunit interface; other site
398580001876	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239
398580001877	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
398580001878	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
398580001879	dimer interface [polypeptide binding]; other site
398580001880	conserved gate region; other site
398580001881	putative PBP binding loops; other site
398580001882	ABC-ATPase subunit interface; other site
398580001883	ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172
398580001884	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
398580001885	Walker A/P-loop; other site
398580001886	ATP binding site [chemical binding]; other site
398580001887	Q-loop/lid; other site
398580001888	ABC transporter signature motif; other site
398580001889	Walker B; other site
398580001890	D-loop; other site
398580001891	H-loop/switch region; other site
398580001892	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
398580001893	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
398580001894	Walker A/P-loop; other site
398580001895	ATP binding site [chemical binding]; other site
398580001896	Q-loop/lid; other site
398580001897	ABC transporter signature motif; other site
398580001898	Walker B; other site
398580001899	D-loop; other site
398580001900	H-loop/switch region; other site
398580001901	coproporphyrinogen III oxidase; Provisional; Region: PRK09249
398580001902	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
398580001903	FeS/SAM binding site; other site
398580001904	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
398580001905	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
398580001906	ligand binding site [chemical binding]; other site
398580001907	flexible hinge region; other site
398580001908	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
398580001909	non-specific DNA interactions [nucleotide binding]; other site
398580001910	DNA binding site [nucleotide binding]
398580001911	sequence specific DNA binding site [nucleotide binding]; other site
398580001912	putative cAMP binding site [chemical binding]; other site
398580001913	Cytochrome cbb3 oxidase subunit I.  Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661
398580001914	Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115
398580001915	Low-spin heme binding site [chemical binding]; other site
398580001916	Putative water exit pathway; other site
398580001917	Binuclear center (active site) [active]
398580001918	Putative proton exit pathway; other site
398580001919	Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993
398580001920	Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; pfam02433
398580001921	Cbb3-type cytochrome oxidase component FixQ; Region: FixQ; pfam05545
398580001922	cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782
398580001923	Cytochrome c; Region: Cytochrom_C; pfam00034
398580001924	Cytochrome c; Region: Cytochrom_C; pfam00034
398580001925	cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745
398580001926	4Fe-4S binding domain; Region: Fer4_5; pfam12801
398580001927	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
398580001928	Ubp3 associated protein Bre5; Region: Bre5; pfam11614
398580001929	Predicted integral membrane protein linked to a cation pump [Inorganic ion transport and metabolism]; Region: COG5456
398580001930	FixH; Region: FixH; pfam05751
398580001931	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
398580001932	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
398580001933	metal-binding site [ion binding]
398580001934	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
398580001935	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
398580001936	motif II; other site
398580001937	cytochrome oxidase maturation protein, cbb3-type; Region: ccoS; TIGR00847
398580001938	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
398580001939	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
398580001940	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
398580001941	16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813
398580001942	Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468
398580001943	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
398580001944	S-adenosylmethionine binding site [chemical binding]; other site
398580001945	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
398580001946	classical (c) SDRs; Region: SDR_c; cd05233
398580001947	NAD(P) binding site [chemical binding]; other site
398580001948	active site
398580001949	coproporphyrinogen III oxidase; Provisional; Region: PRK05330
398580001950	Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218
398580001951	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
398580001952	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
398580001953	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
398580001954	Beta-lactamase; Region: Beta-lactamase; pfam00144
398580001955	Sulfotransferase family; Region: Sulfotransfer_2; pfam03567
398580001956	Core-2/I-Branching enzyme; Region: Branch; pfam02485
398580001957	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
398580001958	nucleotide binding site/active site [active]
398580001959	HIT family signature motif; other site
398580001960	catalytic residue [active]
398580001961	phosphoribosylaminoimidazole carboxylase, PurK protein; Region: purK; TIGR01161
398580001962	ATP-grasp domain; Region: ATP-grasp; pfam02222
398580001963	AIR carboxylase; Region: AIRC; pfam00731
398580001964	Uncharacterized conserved small protein containing a coiled-coil domain [Function unknown]; Region: COG5481
398580001965	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
398580001966	Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins.  IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470
398580001967	putative dimer interface [polypeptide binding]; other site
398580001968	Protein of unknown function (DUF1150); Region: DUF1150; pfam06620
398580001969	ApbE family; Region: ApbE; pfam02424
398580001970	FMN-binding domain; Region: FMN_bind; cl01081
398580001971	Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348
398580001972	4Fe-4S binding domain; Region: Fer4_5; pfam12801
398580001973	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
398580001974	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
398580001975	dimer interface [polypeptide binding]; other site
398580001976	conserved gate region; other site
398580001977	putative PBP binding loops; other site
398580001978	ABC-ATPase subunit interface; other site
398580001979	flavocytochrome c; Region: flavo_cyto_c; TIGR01813
398580001980	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
398580001981	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
398580001982	tetramer interface [polypeptide binding]; other site
398580001983	active site
398580001984	Mg2+/Mn2+ binding site [ion binding]; other site
398580001985	Isochorismatase family; Region: Isochorismatase; pfam00857
398580001986	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
398580001987	catalytic triad [active]
398580001988	conserved cis-peptide bond; other site
398580001989	N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145
398580001990	Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378
398580001991	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968
398580001992	N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146
398580001993	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
398580001994	active site 1 [active]
398580001995	dimer interface [polypeptide binding]; other site
398580001996	hexamer interface [polypeptide binding]; other site
398580001997	active site 2 [active]
398580001998	SnoaL-like domain; Region: SnoaL_2; pfam12680
398580001999	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
398580002000	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
398580002001	DNA-binding site [nucleotide binding]; DNA binding site
398580002002	UTRA domain; Region: UTRA; pfam07702
398580002003	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
398580002004	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
398580002005	substrate binding site [chemical binding]; other site
398580002006	ligand binding site [chemical binding]; other site
398580002007	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
398580002008	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
398580002009	hypothetical protein; Provisional; Region: PRK14812
398580002010	substrate binding site [chemical binding]; other site
398580002011	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
398580002012	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290
398580002013	DctM-like transporters; Region: DctM; pfam06808
398580002014	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
398580002015	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
398580002016	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
398580002017	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
398580002018	acyl-activating enzyme (AAE) consensus motif; other site
398580002019	acyl-activating enzyme (AAE) consensus motif; other site
398580002020	putative AMP binding site [chemical binding]; other site
398580002021	putative active site [active]
398580002022	putative CoA binding site [chemical binding]; other site
398580002023	Methyltransferase domain; Region: Methyltransf_31; pfam13847
398580002024	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
398580002025	S-adenosylmethionine binding site [chemical binding]; other site
398580002026	WbqC-like protein family; Region: WbqC; pfam08889
398580002027	Glycosyl transferase family 2; Region: Glyco_tranf_2_4; pfam13704
398580002028	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
398580002029	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
398580002030	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
398580002031	catalytic residue [active]
398580002032	Protein of unknown function (DUF563); Region: DUF563; pfam04577
398580002033	Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360
398580002034	sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570
398580002035	putative trimer interface [polypeptide binding]; other site
398580002036	putative CoA binding site [chemical binding]; other site
398580002037	Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670
398580002038	Coenzyme A transferase; Region: CoA_trans; smart00882
398580002039	Coenzyme A transferase; Region: CoA_trans; cl17247
398580002040	chromosome replication initiation inhibitor protein; Validated; Region: PRK03635
398580002041	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
398580002042	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
398580002043	dimerization interface [polypeptide binding]; other site
398580002044	Lysine efflux permease [General function prediction only]; Region: COG1279
398580002045	Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509
398580002046	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
398580002047	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
398580002048	EamA-like transporter family; Region: EamA; pfam00892
398580002049	EamA-like transporter family; Region: EamA; pfam00892
398580002050	Protein of unknown function (DUF465); Region: DUF465; cl01070
398580002051	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
398580002052	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
398580002053	non-specific DNA binding site [nucleotide binding]; other site
398580002054	salt bridge; other site
398580002055	sequence-specific DNA binding site [nucleotide binding]; other site
398580002056	Predicted transcriptional regulator [General function prediction only]; Region: COG3800
398580002057	Domain of unknown function (DUF955); Region: DUF955; pfam06114
398580002058	Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856
398580002059	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
398580002060	multidrug resistance protein D; Provisional; Region: emrD; PRK11652
398580002061	putative substrate translocation pore; other site
398580002062	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
398580002063	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
398580002064	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
398580002065	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
398580002066	homotrimer interaction site [polypeptide binding]; other site
398580002067	putative active site [active]
398580002068	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
398580002069	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
398580002070	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
398580002071	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
398580002072	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
398580002073	carboxyltransferase (CT) interaction site; other site
398580002074	biotinylation site [posttranslational modification]; other site
398580002075	Domain of unknown function (DUF4174); Region: DUF4174; pfam13778
398580002076	methylmalonyl-CoA mutase; Reviewed; Region: PRK09426
398580002077	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679
398580002078	active site
398580002079	substrate binding site [chemical binding]; other site
398580002080	coenzyme B12 binding site [chemical binding]; other site
398580002081	methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071
398580002082	B12 binding site [chemical binding]; other site
398580002083	cobalt ligand [ion binding]; other site
398580002084	DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151
398580002085	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
398580002086	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
398580002087	dimerization interface [polypeptide binding]; other site
398580002088	putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12647
398580002089	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
398580002090	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
398580002091	Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111
398580002092	Domain of unknown function (DUF4040); Region: DUF4040; cl00676
398580002093	putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK12658
398580002094	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12663
398580002095	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
398580002096	Na+/H+ ion antiporter subunit; Region: MNHE; pfam01899
398580002097	putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12599
398580002098	putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674
398580002099	Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468
398580002100	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
398580002101	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
398580002102	Coenzyme A binding pocket [chemical binding]; other site
398580002103	N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316
398580002104	DnaJ-domain-containing proteins 1 [Posttranslational modification, protein turnover, chaperones]; Region: DjlA; COG1076
398580002105	putative metal binding site [ion binding]; other site
398580002106	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
398580002107	HSP70 interaction site [polypeptide binding]; other site
398580002108	exopolyphosphatase; Region: exo_poly_only; TIGR03706
398580002109	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
398580002110	nucleotide binding site [chemical binding]; other site
398580002111	polyphosphate kinase; Provisional; Region: PRK05443
398580002112	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
398580002113	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
398580002114	Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165
398580002115	putative domain interface [polypeptide binding]; other site
398580002116	putative active site [active]
398580002117	catalytic site [active]
398580002118	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
398580002119	putative active site [active]
398580002120	catalytic site [active]
398580002121	ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593
398580002122	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
398580002123	Domain of unknown function DUF20; Region: UPF0118; pfam01594
398580002124	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
398580002125	BON domain; Region: BON; pfam04972
398580002126	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
398580002127	Mechanosensitive ion channel; Region: MS_channel; pfam00924
398580002128	prolyl-tRNA synthetase; Provisional; Region: PRK12325
398580002129	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
398580002130	dimer interface [polypeptide binding]; other site
398580002131	motif 1; other site
398580002132	active site
398580002133	motif 2; other site
398580002134	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
398580002135	active site
398580002136	motif 3; other site
398580002137	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
398580002138	anticodon binding site; other site
398580002139	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
398580002140	catalytic triad [active]
398580002141	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
398580002142	amphipathic channel; other site
398580002143	Asn-Pro-Ala signature motifs; other site
398580002144	lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212
398580002145	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
398580002146	FtsX-like permease family; Region: FtsX; pfam02687
398580002147	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
398580002148	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
398580002149	Walker A/P-loop; other site
398580002150	ATP binding site [chemical binding]; other site
398580002151	Q-loop/lid; other site
398580002152	ABC transporter signature motif; other site
398580002153	Walker B; other site
398580002154	D-loop; other site
398580002155	H-loop/switch region; other site
398580002156	DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559
398580002157	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
398580002158	Mg2+ binding site [ion binding]; other site
398580002159	G-X-G motif; other site
398580002160	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
398580002161	anchoring element; other site
398580002162	dimer interface [polypeptide binding]; other site
398580002163	ATP binding site [chemical binding]; other site
398580002164	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
398580002165	active site
398580002166	metal binding site [ion binding]; metal-binding site
398580002167	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
398580002168	polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707
398580002169	Protein of unknown function (DUF1007); Region: DUF1007; pfam06226
398580002170	High-affinity nickel-transport protein; Region: NicO; cl00964
398580002171	High-affinity nickel-transport protein; Region: NicO; cl00964
398580002172	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
398580002173	S-adenosylmethionine binding site [chemical binding]; other site
398580002174	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131
398580002175	putative efflux protein, MATE family; Region: matE; TIGR00797
398580002176	cation binding site [ion binding]; other site
398580002177	56kDa selenium binding protein (SBP56); Region: SBP56; pfam05694
398580002178	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
398580002179	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
398580002180	dimerization interface [polypeptide binding]; other site
398580002181	putative Zn2+ binding site [ion binding]; other site
398580002182	putative DNA binding site [nucleotide binding]; other site
398580002183	NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195
398580002184	aspartate aminotransferase; Provisional; Region: PRK05764
398580002185	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
398580002186	pyridoxal 5'-phosphate binding site [chemical binding]; other site
398580002187	homodimer interface [polypeptide binding]; other site
398580002188	catalytic residue [active]
398580002189	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
398580002190	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
398580002191	non-specific DNA binding site [nucleotide binding]; other site
398580002192	salt bridge; other site
398580002193	sequence-specific DNA binding site [nucleotide binding]; other site
398580002194	Flavinator of succinate dehydrogenase; Region: Sdh5; pfam03937
398580002195	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
398580002196	Protein of unknown function (DUF1194); Region: DUF1194; pfam06707
398580002197	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
398580002198	dimer interface [polypeptide binding]; other site
398580002199	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
398580002200	active site
398580002201	metal binding site [ion binding]; metal-binding site
398580002202	glutathione binding site [chemical binding]; other site
398580002203	FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847
398580002204	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
398580002205	DNA-binding site [nucleotide binding]; DNA binding site
398580002206	RNA-binding motif; other site
398580002207	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
398580002208	ArsC family; Region: ArsC; pfam03960
398580002209	Predicted membrane protein [Function unknown]; Region: COG2259
398580002210	Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; pfam09836
398580002211	hypothetical protein; Provisional; Region: PRK05409
398580002212	Predicted integral membrane protein (DUF2282); Region: DUF2282; pfam10048
398580002213	Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473
398580002214	tartrate dehydrogenase; Region: TTC; TIGR02089
398580002215	B12 binding domain; Region: B12-binding_2; cl03653
398580002216	B12 binding domain; Region: B12-binding; pfam02310
398580002217	B12 binding site [chemical binding]; other site
398580002218	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
398580002219	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
398580002220	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
398580002221	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
398580002222	active site
398580002223	dimer interface [polypeptide binding]; other site
398580002224	motif 1; other site
398580002225	motif 2; other site
398580002226	motif 3; other site
398580002227	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
398580002228	anticodon binding site; other site
398580002229	MarR family; Region: MarR_2; pfam12802
398580002230	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
398580002231	Coenzyme A binding pocket [chemical binding]; other site
398580002232	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
398580002233	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
398580002234	SCP-2 sterol transfer family; Region: SCP2; pfam02036
398580002235	TPR repeat; Region: TPR_11; pfam13414
398580002236	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
398580002237	binding surface
398580002238	TPR motif; other site
398580002239	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
398580002240	ATP binding site [chemical binding]; other site
398580002241	putative Mg++ binding site [ion binding]; other site
398580002242	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
398580002243	nucleotide binding region [chemical binding]; other site
398580002244	ATP-binding site [chemical binding]; other site
398580002245	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940
398580002246	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
398580002247	4Fe-4S binding domain; Region: Fer4; pfam00037
398580002248	Domain of unknown function (DUF3470); Region: DUF3470; pfam11953
398580002249	Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329
398580002250	cobalamin synthase; Reviewed; Region: cobS; PRK00235
398580002251	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
398580002252	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
398580002253	putative dimer interface [polypeptide binding]; other site
398580002254	active site pocket [active]
398580002255	putative cataytic base [active]
398580002256	glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659
398580002257	transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932
398580002258	TrkA-N domain; Region: TrkA_N; pfam02254
398580002259	Protein of unknown function (DUF541); Region: SIMPL; pfam04402
398580002260	Glycine-zipper containing OmpA-like membrane domain; Region: Gly-zipper_OmpA; pfam13436
398580002261	O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873
398580002262	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
398580002263	homodimer interface [polypeptide binding]; other site
398580002264	substrate-cofactor binding pocket; other site
398580002265	pyridoxal 5'-phosphate binding site [chemical binding]; other site
398580002266	catalytic residue [active]
398580002267	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
398580002268	putative active site pocket [active]
398580002269	4-fold oligomerization interface [polypeptide binding]; other site
398580002270	metal binding residues [ion binding]; metal-binding site
398580002271	3-fold/trimer interface [polypeptide binding]; other site
398580002272	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146
398580002273	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
398580002274	putative active site [active]
398580002275	oxyanion strand; other site
398580002276	catalytic triad [active]
398580002277	ornithine carbamoyltransferase; Provisional; Region: PRK00779
398580002278	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
398580002279	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
398580002280	Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523
398580002281	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
398580002282	acetylornithine transaminase protein; Provisional; Region: argD; PRK01278
398580002283	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
398580002284	inhibitor-cofactor binding pocket; inhibition site
398580002285	pyridoxal 5'-phosphate binding site [chemical binding]; other site
398580002286	catalytic residue [active]
398580002287	Protein of unknown function (DUF3140); Region: DUF3140; pfam11338
398580002288	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
398580002289	Transcriptional regulator [Transcription]; Region: IclR; COG1414
398580002290	Bacterial transcriptional regulator; Region: IclR; pfam01614
398580002291	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
398580002292	DctM-like transporters; Region: DctM; pfam06808
398580002293	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
398580002294	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
398580002295	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
398580002296	choline dehydrogenase; Validated; Region: PRK02106
398580002297	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
398580002298	sulfoacetaldehyde acetyltransferase; Validated; Region: PRK07525
398580002299	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
398580002300	PYR/PP interface [polypeptide binding]; other site
398580002301	dimer interface [polypeptide binding]; other site
398580002302	TPP binding site [chemical binding]; other site
398580002303	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
398580002304	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
398580002305	TPP-binding site [chemical binding]; other site
398580002306	Predicted membrane protein [Function unknown]; Region: COG2855
398580002307	Hint domain; Region: Hint_2; pfam13403
398580002308	MltA-interacting protein MipA; Region: MipA; cl01504
398580002309	GTP-binding protein LepA; Provisional; Region: PRK05433
398580002310	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
398580002311	G1 box; other site
398580002312	putative GEF interaction site [polypeptide binding]; other site
398580002313	GTP/Mg2+ binding site [chemical binding]; other site
398580002314	Switch I region; other site
398580002315	G2 box; other site
398580002316	G3 box; other site
398580002317	Switch II region; other site
398580002318	G4 box; other site
398580002319	G5 box; other site
398580002320	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
398580002321	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
398580002322	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
398580002323	Domain of unknown function (DUF4160); Region: DUF4160; pfam13711
398580002324	Protein of unknown function (DUF2442); Region: DUF2442; pfam10387
398580002325	DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734
398580002326	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245
398580002327	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
398580002328	dimer interface [polypeptide binding]; other site
398580002329	putative metal binding site [ion binding]; other site
398580002330	acyl-CoA esterase; Provisional; Region: PRK10673
398580002331	PGAP1-like protein; Region: PGAP1; pfam07819
398580002332	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
398580002333	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
398580002334	dimer interface [polypeptide binding]; other site
398580002335	active site
398580002336	glycine-pyridoxal phosphate binding site [chemical binding]; other site
398580002337	folate binding site [chemical binding]; other site
398580002338	inorganic polyphosphate/ATP-NAD kinase; Reviewed; Region: ppnK; PRK04761
398580002339	ATP-NAD kinase; Region: NAD_kinase; pfam01513
398580002340	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
398580002341	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
398580002342	active site
398580002343	phosphorylation site [posttranslational modification]
398580002344	intermolecular recognition site; other site
398580002345	dimerization interface [polypeptide binding]; other site
398580002346	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
398580002347	Walker A motif; other site
398580002348	ATP binding site [chemical binding]; other site
398580002349	Walker B motif; other site
398580002350	arginine finger; other site
398580002351	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
398580002352	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
398580002353	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
398580002354	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
398580002355	ATP binding site [chemical binding]; other site
398580002356	Mg2+ binding site [ion binding]; other site
398580002357	G-X-G motif; other site
398580002358	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
398580002359	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
398580002360	active site
398580002361	phosphorylation site [posttranslational modification]
398580002362	intermolecular recognition site; other site
398580002363	dimerization interface [polypeptide binding]; other site
398580002364	propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524
398580002365	Propionyl-CoA synthetase (PrpE); Region: PrpE; cd05967
398580002366	acyl-activating enzyme (AAE) consensus motif; other site
398580002367	putative AMP binding site [chemical binding]; other site
398580002368	putative active site [active]
398580002369	putative CoA binding site [chemical binding]; other site
398580002370	malic enzyme; Reviewed; Region: PRK12862
398580002371	Malic enzyme, N-terminal domain; Region: malic; pfam00390
398580002372	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
398580002373	putative NAD(P) binding site [chemical binding]; other site
398580002374	Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280
398580002375	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
398580002376	active site
398580002377	catalytic motif [active]
398580002378	Zn binding site [ion binding]; other site
398580002379	thymidine phosphorylase; Reviewed; Region: deoA; PRK05820
398580002380	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
398580002381	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
398580002382	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941
398580002383	phosphopentomutase; Provisional; Region: PRK05362
398580002384	Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676
398580002385	adenosine deaminase; Provisional; Region: PRK09358
398580002386	active site
398580002387	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
398580002388	active site
398580002389	acyl-CoA synthetase; Validated; Region: PRK08162
398580002390	Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; Region: ttLC_FACS_AEE21_like; cd12118
398580002391	acyl-activating enzyme (AAE) consensus motif; other site
398580002392	putative active site [active]
398580002393	AMP binding site [chemical binding]; other site
398580002394	putative CoA binding site [chemical binding]; other site
398580002395	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154
398580002396	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
398580002397	substrate binding site [chemical binding]; other site
398580002398	oxyanion hole (OAH) forming residues; other site
398580002399	trimer interface [polypeptide binding]; other site
398580002400	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
398580002401	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
398580002402	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
398580002403	acetyl-CoA acetyltransferase; Validated; Region: PRK08242
398580002404	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
398580002405	dimer interface [polypeptide binding]; other site
398580002406	active site
398580002407	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
398580002408	GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056
398580002409	putative C-terminal domain interface [polypeptide binding]; other site
398580002410	putative GSH binding site (G-site) [chemical binding]; other site
398580002411	putative dimer interface [polypeptide binding]; other site
398580002412	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
398580002413	N-terminal domain interface [polypeptide binding]; other site
398580002414	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
398580002415	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
398580002416	active site
398580002417	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
398580002418	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
398580002419	Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153
398580002420	FAD binding site [chemical binding]; other site
398580002421	substrate binding site [chemical binding]; other site
398580002422	catalytic residues [active]
398580002423	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
398580002424	Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776
398580002425	DNA binding residues [nucleotide binding]
398580002426	putative dimer interface [polypeptide binding]; other site
398580002427	GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472
398580002428	Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776
398580002429	DNA binding residues [nucleotide binding]
398580002430	Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047
398580002431	putative dimer interface [polypeptide binding]; other site
398580002432	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
398580002433	CoenzymeA binding site [chemical binding]; other site
398580002434	subunit interaction site [polypeptide binding]; other site
398580002435	PHB binding site; other site
398580002436	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
398580002437	CoenzymeA binding site [chemical binding]; other site
398580002438	subunit interaction site [polypeptide binding]; other site
398580002439	PHB binding site; other site
398580002440	Thioesterase-like superfamily; Region: 4HBT_3; pfam13622
398580002441	DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136
398580002442	DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367
398580002443	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
398580002444	ArsC family; Region: ArsC; pfam03960
398580002445	catalytic residues [active]
398580002446	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
398580002447	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
398580002448	quinone interaction residues [chemical binding]; other site
398580002449	active site
398580002450	catalytic residues [active]
398580002451	FMN binding site [chemical binding]; other site
398580002452	substrate binding site [chemical binding]; other site
398580002453	Protein of unknown function (DUF952); Region: DUF952; cl01393
398580002454	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
398580002455	CD73 ecto-5'-nucleotidase and related proteins, N-terminal metallophosphatase domain; Region: MPP_CD73_N; cd07409
398580002456	active site
398580002457	metal binding site [ion binding]; metal-binding site
398580002458	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
398580002459	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
398580002460	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
398580002461	ATP binding site [chemical binding]; other site
398580002462	putative Mg++ binding site [ion binding]; other site
398580002463	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
398580002464	nucleotide binding region [chemical binding]; other site
398580002465	ATP-binding site [chemical binding]; other site
398580002466	RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252
398580002467	RNA binding site [nucleotide binding]; other site
398580002468	Uncharacterized conserved protein [Function unknown]; Region: COG2135
398580002469	ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204
398580002470	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
398580002471	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
398580002472	Walker A/P-loop; other site
398580002473	ATP binding site [chemical binding]; other site
398580002474	Q-loop/lid; other site
398580002475	ABC transporter signature motif; other site
398580002476	Walker B; other site
398580002477	D-loop; other site
398580002478	H-loop/switch region; other site
398580002479	AMP-binding domain protein; Validated; Region: PRK07529
398580002480	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
398580002481	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_4; cd05944
398580002482	acyl-activating enzyme (AAE) consensus motif; other site
398580002483	putative AMP binding site [chemical binding]; other site
398580002484	putative active site [active]
398580002485	putative CoA binding site [chemical binding]; other site
398580002486	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
398580002487	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
398580002488	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
398580002489	A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448
398580002490	A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168
398580002491	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307
398580002492	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
398580002493	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
398580002494	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
398580002495	Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899
398580002496	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4196
398580002497	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
398580002498	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
398580002499	Walker A/P-loop; other site
398580002500	ATP binding site [chemical binding]; other site
398580002501	Q-loop/lid; other site
398580002502	ABC transporter signature motif; other site
398580002503	Walker B; other site
398580002504	D-loop; other site
398580002505	H-loop/switch region; other site
398580002506	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
398580002507	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
398580002508	Walker A/P-loop; other site
398580002509	ATP binding site [chemical binding]; other site
398580002510	Q-loop/lid; other site
398580002511	ABC transporter signature motif; other site
398580002512	Walker B; other site
398580002513	D-loop; other site
398580002514	H-loop/switch region; other site
398580002515	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
398580002516	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
398580002517	TM-ABC transporter signature motif; other site
398580002518	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
398580002519	TM-ABC transporter signature motif; other site
398580002520	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
398580002521	Type I periplasmic binding component of active transport systems that are predicted to be involved in 2-nitrobenzoic acid degradation pathway; Region: PBP1_Nba_like; cd06359
398580002522	putative ligand binding site [chemical binding]; other site
398580002523	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
398580002524	AsnC family; Region: AsnC_trans_reg; pfam01037
398580002525	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
398580002526	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
398580002527	catalytic loop [active]
398580002528	iron binding site [ion binding]; other site
398580002529	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
398580002530	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
398580002531	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
398580002532	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
398580002533	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
398580002534	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
398580002535	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
398580002536	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
398580002537	active site
398580002538	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
398580002539	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
398580002540	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
398580002541	active site
398580002542	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
398580002543	Tetratricopeptide repeat; Region: TPR_16; pfam13432
398580002544	TPR motif; other site
398580002545	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
398580002546	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498
398580002547	VPLPA-CTERM protein sorting domain; Region: VPLPA-CTERM; TIGR03370
398580002548	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
398580002549	Transposase; Region: HTH_Tnp_1; pfam01527
398580002550	putative transposase OrfB; Reviewed; Region: PHA02517
398580002551	HTH-like domain; Region: HTH_21; pfam13276
398580002552	Integrase core domain; Region: rve; pfam00665
398580002553	Integrase core domain; Region: rve_3; pfam13683
398580002554	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498
398580002555	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
398580002556	Predicted membrane protein [Function unknown]; Region: COG3671
398580002557	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
398580002558	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
398580002559	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
398580002560	dimer interface [polypeptide binding]; other site
398580002561	conserved gate region; other site
398580002562	putative PBP binding loops; other site
398580002563	ABC-ATPase subunit interface; other site
398580002564	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
398580002565	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
398580002566	dimer interface [polypeptide binding]; other site
398580002567	conserved gate region; other site
398580002568	ABC-ATPase subunit interface; other site
398580002569	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
398580002570	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
398580002571	Walker A/P-loop; other site
398580002572	ATP binding site [chemical binding]; other site
398580002573	Q-loop/lid; other site
398580002574	ABC transporter signature motif; other site
398580002575	Walker B; other site
398580002576	D-loop; other site
398580002577	H-loop/switch region; other site
398580002578	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
398580002579	dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308
398580002580	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
398580002581	Walker A/P-loop; other site
398580002582	ATP binding site [chemical binding]; other site
398580002583	Q-loop/lid; other site
398580002584	ABC transporter signature motif; other site
398580002585	Walker B; other site
398580002586	D-loop; other site
398580002587	H-loop/switch region; other site
398580002588	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
398580002589	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
398580002590	Transcriptional regulator [Transcription]; Region: IclR; COG1414
398580002591	Bacterial transcriptional regulator; Region: IclR; pfam01614
398580002592	Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451
398580002593	homodimer interface [polypeptide binding]; other site
398580002594	pyridoxal 5'-phosphate binding site [chemical binding]; other site
398580002595	catalytic residue [active]
398580002596	serine racemase; Region: PLN02970
398580002597	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
398580002598	tetramer interface [polypeptide binding]; other site
398580002599	pyridoxal 5'-phosphate binding site [chemical binding]; other site
398580002600	catalytic residue [active]
398580002601	Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616
398580002602	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Low Specificity D-Threonine Aldolase; Region: PLPDE_III_LS_D-TA; cd06819
398580002603	dimer interface [polypeptide binding]; other site
398580002604	active site
398580002605	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
398580002606	substrate binding site [chemical binding]; other site
398580002607	catalytic residue [active]
398580002608	Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423
398580002609	ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400
398580002610	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
398580002611	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
398580002612	dimer interface [polypeptide binding]; other site
398580002613	pyridoxal 5'-phosphate binding site [chemical binding]; other site
398580002614	catalytic residue [active]
398580002615	Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737
398580002616	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
398580002617	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
398580002618	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
398580002619	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
398580002620	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
398580002621	Virulence factor SrfB; Region: SrfB; pfam07520
398580002622	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
398580002623	Putative bacterial virulence factor; Region: Virul_Fac; pfam10139
398580002624	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
398580002625	metal ion-dependent adhesion site (MIDAS); other site
398580002626	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
398580002627	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
398580002628	Q-loop/lid; other site
398580002629	ABC transporter signature motif; other site
398580002630	Walker B; other site
398580002631	D-loop; other site
398580002632	H-loop/switch region; other site
398580002633	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
398580002634	Predicted membrane protein [Function unknown]; Region: COG2860
398580002635	UPF0126 domain; Region: UPF0126; pfam03458
398580002636	UPF0126 domain; Region: UPF0126; pfam03458
398580002637	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
398580002638	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
398580002639	dimer interface [polypeptide binding]; other site
398580002640	conserved gate region; other site
398580002641	putative PBP binding loops; other site
398580002642	ABC-ATPase subunit interface; other site
398580002643	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
398580002644	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
398580002645	Walker A/P-loop; other site
398580002646	ATP binding site [chemical binding]; other site
398580002647	Q-loop/lid; other site
398580002648	ABC transporter signature motif; other site
398580002649	Walker B; other site
398580002650	D-loop; other site
398580002651	H-loop/switch region; other site
398580002652	Putative transcription activator [Transcription]; Region: TenA; COG0819
398580002653	NMT1/THI5 like; Region: NMT1; pfam09084
398580002654	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
398580002655	membrane-bound complex binding site; other site
398580002656	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
398580002657	thiazole biosynthesis adenylyltransferase ThiF, E. coli subfamily; Region: adenyl_thiF; TIGR02356
398580002658	ATP binding site [chemical binding]; other site
398580002659	substrate interface [chemical binding]; other site
398580002660	MoeZ/MoeB domain; Region: MoeZ_MoeB; pfam05237
398580002661	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
398580002662	thiamine phosphate binding site [chemical binding]; other site
398580002663	active site
398580002664	pyrophosphate binding site [ion binding]; other site
398580002665	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
398580002666	ThiS interaction site; other site
398580002667	putative active site [active]
398580002668	tetramer interface [polypeptide binding]; other site
398580002669	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
398580002670	thiS-thiF/thiG interaction site; other site
398580002671	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
398580002672	glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352
398580002673	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
398580002674	dimer interface [polypeptide binding]; other site
398580002675	substrate binding site [chemical binding]; other site
398580002676	ATP binding site [chemical binding]; other site
398580002677	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
398580002678	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
398580002679	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
398580002680	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
398580002681	Protein export membrane protein; Region: SecD_SecF; cl14618
398580002682	Predicted permeases [General function prediction only]; Region: COG0679
398580002683	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
398580002684	putative hydrolase; Provisional; Region: PRK02113
398580002685	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
398580002686	active site
398580002687	DNA polymerase III subunit delta'; Validated; Region: PRK07471
398580002688	DNA polymerase III subunit delta'; Validated; Region: PRK08485
398580002689	Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125
398580002690	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
398580002691	TMP-binding site; other site
398580002692	ATP-binding site [chemical binding]; other site
398580002693	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
398580002694	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
398580002695	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936
398580002696	Sporulation related domain; Region: SPOR; pfam05036
398580002697	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
398580002698	Catalytic site [active]
398580002699	HTH-like domain; Region: HTH_21; pfam13276
398580002700	Integrase core domain; Region: rve; pfam00665
398580002701	Integrase core domain; Region: rve_3; pfam13683
398580002702	Transposase; Region: HTH_Tnp_1; cl17663
398580002703	copper/silver efflux system membrane fusion protein CusB; Provisional; Region: PRK09783
398580002704	HlyD family secretion protein; Region: HlyD_3; pfam13437
398580002705	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
398580002706	Ligand Binding Site [chemical binding]; other site
398580002707	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
398580002708	Ligand Binding Site [chemical binding]; other site
398580002709	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
398580002710	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
398580002711	TrkA-N domain; Region: TrkA_N; pfam02254
398580002712	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
398580002713	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297
398580002714	NAD binding site [chemical binding]; other site
398580002715	substrate binding site [chemical binding]; other site
398580002716	catalytic Zn binding site [ion binding]; other site
398580002717	tetramer interface [polypeptide binding]; other site
398580002718	structural Zn binding site [ion binding]; other site
398580002719	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
398580002720	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
398580002721	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
398580002722	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
398580002723	Soluble P-type ATPase [General function prediction only]; Region: COG4087
398580002724	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
398580002725	Helix-turn-helix domain; Region: HTH_17; pfam12728
398580002726	Transposase; Region: HTH_Tnp_1; pfam01527
398580002727	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4782
398580002728	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
398580002729	Sulfatase; Region: Sulfatase; cl17466
398580002730	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
398580002731	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
398580002732	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
398580002733	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; cl17722
398580002734	Peptidase family M23; Region: Peptidase_M23; pfam01551
398580002735	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
398580002736	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539
398580002737	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
398580002738	Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; pfam09996
398580002739	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
398580002740	putative active site [active]
398580002741	catalytic residue [active]
398580002742	L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197
398580002743	Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809
398580002744	active site
398580002745	substrate binding site [chemical binding]; other site
398580002746	FMN binding site [chemical binding]; other site
398580002747	putative catalytic residues [active]
398580002748	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
398580002749	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
398580002750	5S rRNA interface [nucleotide binding]; other site
398580002751	CTC domain interface [polypeptide binding]; other site
398580002752	L16 interface [polypeptide binding]; other site
398580002753	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
398580002754	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
398580002755	substrate binding site [chemical binding]; other site
398580002756	active site
398580002757	catalytic residues [active]
398580002758	heterodimer interface [polypeptide binding]; other site
398580002759	multidrug efflux protein; Reviewed; Region: PRK01766
398580002760	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131
398580002761	cation binding site [ion binding]; other site
398580002762	GTP-binding protein YchF; Reviewed; Region: PRK09601
398580002763	YchF GTPase; Region: YchF; cd01900
398580002764	G1 box; other site
398580002765	GTP/Mg2+ binding site [chemical binding]; other site
398580002766	Switch I region; other site
398580002767	G2 box; other site
398580002768	Switch II region; other site
398580002769	G3 box; other site
398580002770	G4 box; other site
398580002771	G5 box; other site
398580002772	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
398580002773	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
398580002774	DctM-like transporters; Region: DctM; pfam06808
398580002775	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
398580002776	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
398580002777	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
398580002778	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
398580002779	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
398580002780	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
398580002781	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
398580002782	putative active site [active]
398580002783	Transcriptional regulators [Transcription]; Region: FadR; COG2186
398580002784	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
398580002785	DNA-binding site [nucleotide binding]; DNA binding site
398580002786	FCD domain; Region: FCD; pfam07729
398580002787	Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208
398580002788	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290
398580002789	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
398580002790	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
398580002791	YCII-related domain; Region: YCII; cl00999
398580002792	Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246
398580002793	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
398580002794	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
398580002795	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
398580002796	active site
398580002797	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
398580002798	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
398580002799	Walker A/P-loop; other site
398580002800	ATP binding site [chemical binding]; other site
398580002801	Q-loop/lid; other site
398580002802	ABC transporter signature motif; other site
398580002803	Walker B; other site
398580002804	D-loop; other site
398580002805	H-loop/switch region; other site
398580002806	TOBE domain; Region: TOBE_2; pfam08402
398580002807	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
398580002808	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
398580002809	dimer interface [polypeptide binding]; other site
398580002810	conserved gate region; other site
398580002811	ABC-ATPase subunit interface; other site
398580002812	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
398580002813	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
398580002814	dimer interface [polypeptide binding]; other site
398580002815	conserved gate region; other site
398580002816	putative PBP binding loops; other site
398580002817	ABC-ATPase subunit interface; other site
398580002818	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
398580002819	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
398580002820	Transcriptional regulators [Transcription]; Region: PurR; COG1609
398580002821	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
398580002822	DNA binding site [nucleotide binding]
398580002823	domain linker motif; other site
398580002824	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
398580002825	dimerization interface [polypeptide binding]; other site
398580002826	ligand binding site [chemical binding]; other site
398580002827	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
398580002828	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
398580002829	hinge; other site
398580002830	active site
398580002831	Protein of unknown function (DUF2948); Region: DUF2948; pfam11164
398580002832	Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141
398580002833	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
398580002834	NAD binding site [chemical binding]; other site
398580002835	dimerization interface [polypeptide binding]; other site
398580002836	product binding site; other site
398580002837	substrate binding site [chemical binding]; other site
398580002838	zinc binding site [ion binding]; other site
398580002839	catalytic residues [active]
398580002840	hypothetical protein; Provisional; Region: PRK02853
398580002841	Low molecular weight phosphatase family; Region: LMWPc; cl00105
398580002842	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
398580002843	active site
398580002844	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
398580002845	rRNA binding site [nucleotide binding]; other site
398580002846	predicted 30S ribosome binding site; other site
398580002847	Maf-like protein; Region: Maf; pfam02545
398580002848	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
398580002849	active site
398580002850	dimer interface [polypeptide binding]; other site
398580002851	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
398580002852	RNA binding site [nucleotide binding]; other site
398580002853	Ribonuclease E/G family; Region: RNase_E_G; pfam10150
398580002854	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
398580002855	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
398580002856	non-specific DNA binding site [nucleotide binding]; other site
398580002857	salt bridge; other site
398580002858	sequence-specific DNA binding site [nucleotide binding]; other site
398580002859	Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470
398580002860	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
398580002861	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
398580002862	active site
398580002863	catalytic residues [active]
398580002864	DNA binding site [nucleotide binding]
398580002865	Int/Topo IB signature motif; other site
398580002866	Helix-turn-helix domain; Region: HTH_17; pfam12728
398580002867	Protein of unknown function (DUF4011); Region: DUF4011; pfam13195
398580002868	Part of AAA domain; Region: AAA_19; pfam13245
398580002869	Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112
398580002870	AAA domain; Region: AAA_12; pfam13087
398580002871	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
398580002872	putative active site [active]
398580002873	Protein of unknown function (DUF3320); Region: DUF3320; pfam11784
398580002874	Catalytic domain of type II restriction endonucleases BfiI and NgoFVII, and uncharacterized proteins with a DEAD domain; Region: PLDc_Bfil_DEXD_like; cd09117
398580002875	PLD-like domain; Region: PLDc_2; pfam13091
398580002876	homodimer interface [polypeptide binding]; other site
398580002877	putative active site [active]
398580002878	catalytic site [active]
398580002879	N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b3; cd09205
398580002880	PLD-like domain; Region: PLDc_2; pfam13091
398580002881	putative homodimer interface [polypeptide binding]; other site
398580002882	putative active site [active]
398580002883	catalytic site [active]
398580002884	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
398580002885	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
398580002886	ATP binding site [chemical binding]; other site
398580002887	putative Mg++ binding site [ion binding]; other site
398580002888	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
398580002889	nucleotide binding region [chemical binding]; other site
398580002890	ATP-binding site [chemical binding]; other site
398580002891	Domain of unknown function (DUF3427); Region: DUF3427; pfam11907
398580002892	TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358
398580002893	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
398580002894	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274
398580002895	DctM-like transporters; Region: DctM; pfam06808
398580002896	Transcriptional regulator [Transcription]; Region: LysR; COG0583
398580002897	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
398580002898	LysR substrate binding domain; Region: LysR_substrate; pfam03466
398580002899	dimerization interface [polypeptide binding]; other site
398580002900	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
398580002901	Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070
398580002902	Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001
398580002903	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
398580002904	Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295
398580002905	active site
398580002906	Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382
398580002907	bile acid transporter; Region: bass; TIGR00841
398580002908	Sodium Bile acid symporter family; Region: SBF; pfam01758
398580002909	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974
398580002910	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
398580002911	acyl-activating enzyme (AAE) consensus motif; other site
398580002912	putative AMP binding site [chemical binding]; other site
398580002913	putative active site [active]
398580002914	putative CoA binding site [chemical binding]; other site
398580002915	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
398580002916	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
398580002917	ligand binding site [chemical binding]; other site
398580002918	NAD binding site [chemical binding]; other site
398580002919	dimerization interface [polypeptide binding]; other site
398580002920	catalytic site [active]
398580002921	Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626
398580002922	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
398580002923	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
398580002924	catalytic residue [active]
398580002925	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
398580002926	putative active site [active]
398580002927	putative substrate binding site [chemical binding]; other site
398580002928	ATP binding site [chemical binding]; other site
398580002929	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
398580002930	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
398580002931	active site
398580002932	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
398580002933	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
398580002934	Major Facilitator Superfamily; Region: MFS_1; pfam07690
398580002935	putative substrate translocation pore; other site
398580002936	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
398580002937	Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623
398580002938	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
398580002939	NAD binding site [chemical binding]; other site
398580002940	homotetramer interface [polypeptide binding]; other site
398580002941	homodimer interface [polypeptide binding]; other site
398580002942	substrate binding site [chemical binding]; other site
398580002943	active site
398580002944	3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967
398580002945	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
398580002946	dimer interface [polypeptide binding]; other site
398580002947	active site
398580002948	FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287
398580002949	active site 1 [active]
398580002950	dimer interface [polypeptide binding]; other site
398580002951	active site 2 [active]
398580002952	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
398580002953	metal binding site 2 [ion binding]; metal-binding site
398580002954	putative DNA binding helix; other site
398580002955	metal binding site 1 [ion binding]; metal-binding site
398580002956	dimer interface [polypeptide binding]; other site
398580002957	structural Zn2+ binding site [ion binding]; other site
398580002958	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
398580002959	S-adenosylmethionine synthetase; Validated; Region: PRK05250
398580002960	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
398580002961	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
398580002962	apolipoprotein N-acyltransferase; Region: lnt; TIGR00546
398580002963	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
398580002964	putative active site [active]
398580002965	catalytic triad [active]
398580002966	putative dimer interface [polypeptide binding]; other site
398580002967	FOG: CBS domain [General function prediction only]; Region: COG0517
398580002968	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
398580002969	Transporter associated domain; Region: CorC_HlyC; smart01091
398580002970	Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130
398580002971	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
398580002972	PhoH-like protein; Region: PhoH; pfam02562
398580002973	TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785
398580002974	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
398580002975	N-terminal plug; other site
398580002976	ligand-binding site [chemical binding]; other site
398580002977	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325
398580002978	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
398580002979	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
398580002980	FeS/SAM binding site; other site
398580002981	TRAM domain; Region: TRAM; cl01282
398580002982	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
398580002983	tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121
398580002984	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
398580002985	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
398580002986	hinge; other site
398580002987	active site
398580002988	cytidylate kinase; Provisional; Region: cmk; PRK00023
398580002989	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
398580002990	CMP-binding site; other site
398580002991	The sites determining sugar specificity; other site
398580002992	H-NS histone family; Region: Histone_HNS; pfam00816
398580002993	Domain in histone-like proteins of HNS family; Region: HNS; smart00528
398580002994	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299
398580002995	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
398580002996	RNA binding site [nucleotide binding]; other site
398580002997	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
398580002998	RNA binding site [nucleotide binding]; other site
398580002999	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
398580003000	RNA binding site [nucleotide binding]; other site
398580003001	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
398580003002	RNA binding site [nucleotide binding]; other site
398580003003	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
398580003004	RNA binding site [nucleotide binding]; other site
398580003005	S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691
398580003006	RNA binding site [nucleotide binding]; other site
398580003007	Intracellular septation protein A; Region: IspA; cl01098
398580003008	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
398580003009	IHF dimer interface [polypeptide binding]; other site
398580003010	IHF - DNA interface [nucleotide binding]; other site
398580003011	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
398580003012	active site
398580003013	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
398580003014	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
398580003015	pyridoxal 5'-phosphate binding site [chemical binding]; other site
398580003016	catalytic residue [active]
398580003017	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
398580003018	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
398580003019	DNA binding residues [nucleotide binding]
398580003020	dimerization interface [polypeptide binding]; other site
398580003021	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
398580003022	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290
398580003023	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274
398580003024	DctM-like transporters; Region: DctM; pfam06808
398580003025	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
398580003026	FAD binding domain; Region: FAD_binding_3; pfam01494
398580003027	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
398580003028	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
398580003029	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
398580003030	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
398580003031	DctM-like transporters; Region: DctM; pfam06808
398580003032	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
398580003033	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290
398580003034	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
398580003035	Transcriptional regulators [Transcription]; Region: GntR; COG1802
398580003036	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
398580003037	DNA-binding site [nucleotide binding]; DNA binding site
398580003038	FCD domain; Region: FCD; pfam07729
398580003039	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
398580003040	Amidase; Region: Amidase; cl11426
398580003041	Amidase; Region: Amidase; cl11426
398580003042	Uncharacterized conserved protein [Function unknown]; Region: COG3777
398580003043	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
398580003044	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
398580003045	active site 2 [active]
398580003046	active site 1 [active]
398580003047	enoyl-CoA hydratase; Provisional; Region: PRK06127
398580003048	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
398580003049	substrate binding site [chemical binding]; other site
398580003050	oxyanion hole (OAH) forming residues; other site
398580003051	trimer interface [polypeptide binding]; other site
398580003052	short chain dehydrogenase; Provisional; Region: PRK06125
398580003053	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
398580003054	NAD(P) binding site [chemical binding]; other site
398580003055	active site
398580003056	ChrR Cupin-like domain; Region: Cupin_7; pfam12973
398580003057	MmgE/PrpD family; Region: MmgE_PrpD; cl00912
398580003058	MmgE/PrpD family; Region: MmgE_PrpD; cl00912
398580003059	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
398580003060	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
398580003061	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
398580003062	dimer interface [polypeptide binding]; other site
398580003063	conserved gate region; other site
398580003064	putative PBP binding loops; other site
398580003065	ABC-ATPase subunit interface; other site
398580003066	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
398580003067	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
398580003068	dimer interface [polypeptide binding]; other site
398580003069	conserved gate region; other site
398580003070	putative PBP binding loops; other site
398580003071	ABC-ATPase subunit interface; other site
398580003072	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
398580003073	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
398580003074	Walker A/P-loop; other site
398580003075	ATP binding site [chemical binding]; other site
398580003076	Q-loop/lid; other site
398580003077	ABC transporter signature motif; other site
398580003078	Walker B; other site
398580003079	D-loop; other site
398580003080	H-loop/switch region; other site
398580003081	TOBE domain; Region: TOBE_2; pfam08402
398580003082	Putative catalytic domain of uncharacterized prokaryotic polysaccharide deacetylases similar to bacterial PuuE allantoinases; Region: CE4_PuuE_like; cd10979
398580003083	putative active site [active]
398580003084	putative catalytic site [active]
398580003085	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
398580003086	CoA-transferase family III; Region: CoA_transf_3; pfam02515
398580003087	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
398580003088	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
398580003089	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
398580003090	active site
398580003091	Protein of unknown function (DUF560); Region: DUF560; pfam04575
398580003092	Transferrin binding protein-like solute binding protein; Region: Lipoprotein_5; pfam01298
398580003093	Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488
398580003094	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
398580003095	Protein of unknown function (DUF1289); Region: DUF1289; pfam06945
398580003096	Holliday junction resolvase-like protein; Reviewed; Region: PRK00109
398580003097	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
398580003098	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
398580003099	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
398580003100	Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166
398580003101	Protein of unknown function (DUF1638); Region: DUF1638; pfam07796
398580003102	Putative heavy-metal-binding; Region: YbjQ_1; cl00426
398580003103	Predicted cobalamin binding protein [General function prediction only]; Region: COG5012
398580003104	B12 binding domain of corrinoid proteins. A family of small methanogenic corrinoid proteins that bind methyl-Co(III) 5-hydroxybenzimidazolylcobamide as a cofactor. They play a role on the methanogenesis from trimethylamine, dimethylamine or...; Region: corrinoid_protein_B12-BD; cd02070
398580003105	B12 binding site [chemical binding]; other site
398580003106	cobalt ligand [ion binding]; other site
398580003107	methionine synthase I; Validated; Region: PRK07534
398580003108	Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574
398580003109	Domain of unknown function (DUF1476); Region: DUF1476; pfam07345
398580003110	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
398580003111	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
398580003112	ATP binding site [chemical binding]; other site
398580003113	active site
398580003114	substrate binding site [chemical binding]; other site
398580003115	Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700
398580003116	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH6; cd08260
398580003117	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
398580003118	putative NAD(P) binding site [chemical binding]; other site
398580003119	catalytic Zn binding site [ion binding]; other site
398580003120	structural Zn binding site [ion binding]; other site
398580003121	phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619
398580003122	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
398580003123	putative active site [active]
398580003124	catalytic triad [active]
398580003125	Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191
398580003126	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
398580003127	dimer interface [polypeptide binding]; other site
398580003128	phosphorylation site [posttranslational modification]
398580003129	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
398580003130	ATP binding site [chemical binding]; other site
398580003131	Mg2+ binding site [ion binding]; other site
398580003132	G-X-G motif; other site
398580003133	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
398580003134	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
398580003135	active site
398580003136	phosphorylation site [posttranslational modification]
398580003137	intermolecular recognition site; other site
398580003138	dimerization interface [polypeptide binding]; other site
398580003139	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
398580003140	Walker A motif; other site
398580003141	ATP binding site [chemical binding]; other site
398580003142	Walker B motif; other site
398580003143	arginine finger; other site
398580003144	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
398580003145	arginyl-tRNA-protein transferase; Provisional; Region: PRK01305
398580003146	Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376
398580003147	Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377
398580003148	RDD family; Region: RDD; pfam06271
398580003149	Protein of unknown function (DUF2852); Region: DUF2852; pfam11014
398580003150	This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens  ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333
398580003151	putative deacylase active site [active]
398580003152	TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358
398580003153	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
398580003154	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274
398580003155	DctM-like transporters; Region: DctM; pfam06808
398580003156	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
398580003157	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
398580003158	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290
398580003159	DctM-like transporters; Region: DctM; pfam06808
398580003160	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
398580003161	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
398580003162	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
398580003163	tetramer interface [polypeptide binding]; other site
398580003164	active site
398580003165	Mg2+/Mn2+ binding site [ion binding]; other site
398580003166	Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284
398580003167	GAF domain; Region: GAF; pfam01590
398580003168	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
398580003169	DNA-binding interface [nucleotide binding]; DNA binding site
398580003170	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
398580003171	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
398580003172	NAD(P) binding site [chemical binding]; other site
398580003173	catalytic residues [active]
398580003174	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
398580003175	active site
398580003176	catalytic triad [active]
398580003177	oxyanion hole [active]
398580003178	methionine sulfoxide reductase A; Provisional; Region: PRK00058
398580003179	Methyltransferase domain; Region: Methyltransf_31; pfam13847
398580003180	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
398580003181	S-adenosylmethionine binding site [chemical binding]; other site
398580003182	Uncharacterized conserved small protein [Function unknown]; Region: COG5457
398580003183	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
398580003184	active site
398580003185	putative DNA-binding cleft [nucleotide binding]; other site
398580003186	dimer interface [polypeptide binding]; other site
398580003187	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
398580003188	RuvA N terminal domain; Region: RuvA_N; pfam01330
398580003189	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
398580003190	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
398580003191	Walker A motif; other site
398580003192	ATP binding site [chemical binding]; other site
398580003193	Walker B motif; other site
398580003194	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
398580003195	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
398580003196	active site
398580003197	TolQ protein; Region: tolQ; TIGR02796
398580003198	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
398580003199	TolR protein; Region: tolR; TIGR02801
398580003200	translocation protein TolB; Provisional; Region: tolB; PRK05137
398580003201	TolB amino-terminal domain; Region: TolB_N; pfam04052
398580003202	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
398580003203	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
398580003204	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
398580003205	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
398580003206	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
398580003207	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
398580003208	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
398580003209	ligand binding site [chemical binding]; other site
398580003210	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
398580003211	Tetratricopeptide repeat; Region: TPR_16; pfam13432
398580003212	binding surface
398580003213	TPR motif; other site
398580003214	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
398580003215	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
398580003216	Ligand Binding Site [chemical binding]; other site
398580003217	FtsH Extracellular; Region: FtsH_ext; pfam06480
398580003218	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
398580003219	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
398580003220	Walker A motif; other site
398580003221	ATP binding site [chemical binding]; other site
398580003222	Walker B motif; other site
398580003223	arginine finger; other site
398580003224	Peptidase family M41; Region: Peptidase_M41; pfam01434
398580003225	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
398580003226	CoenzymeA binding site [chemical binding]; other site
398580003227	subunit interaction site [polypeptide binding]; other site
398580003228	PHB binding site; other site
398580003229	metallophosphoesterase, DNA ligase-associated; Region: P_estr_lig_assc; TIGR04123
398580003230	active site
398580003231	metal binding site [ion binding]; metal-binding site
398580003232	DEXH box helicase, DNA ligase-associated; Region: DEXH_lig_assoc; TIGR04121
398580003233	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
398580003234	ATP binding site [chemical binding]; other site
398580003235	putative Mg++ binding site [ion binding]; other site
398580003236	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
398580003237	nucleotide binding region [chemical binding]; other site
398580003238	ATP-binding site [chemical binding]; other site
398580003239	DEAD/H associated; Region: DEAD_assoc; pfam08494
398580003240	RNA helicase; Region: RNA_helicase; pfam00910
398580003241	Flp pilus assembly protein, protease CpaA [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: CpaA; COG4960
398580003242	type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521
398580003243	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
398580003244	TPR motif; other site
398580003245	binding surface
398580003246	Tetratricopeptide repeat; Region: TPR_12; pfam13424
398580003247	Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064
398580003248	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
398580003249	Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965
398580003250	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
398580003251	Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962
398580003252	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
398580003253	ATP binding site [chemical binding]; other site
398580003254	Walker A motif; other site
398580003255	hexamer interface [polypeptide binding]; other site
398580003256	Walker B motif; other site
398580003257	Flp pilus assembly protein, ATPase CpaE [Intracellular trafficking and secretion]; Region: CpaE; COG4963
398580003258	This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111
398580003259	This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111
398580003260	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
398580003261	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
398580003262	ligand binding site [chemical binding]; other site
398580003263	Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964
398580003264	Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629
398580003265	BON domain; Region: BON; pfam04972
398580003266	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
398580003267	Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745
398580003268	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
398580003269	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
398580003270	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
398580003271	N-acetyl-D-glucosamine binding site [chemical binding]; other site
398580003272	catalytic residue [active]
398580003273	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
398580003274	PAS domain; Region: PAS_9; pfam13426
398580003275	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
398580003276	putative active site [active]
398580003277	heme pocket [chemical binding]; other site
398580003278	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
398580003279	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
398580003280	ATP binding site [chemical binding]; other site
398580003281	Mg2+ binding site [ion binding]; other site
398580003282	G-X-G motif; other site
398580003283	Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788
398580003284	DNA topoisomerase I subunit omega; Validated; Region: PRK07561
398580003285	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
398580003286	active site
398580003287	interdomain interaction site; other site
398580003288	putative metal-binding site [ion binding]; other site
398580003289	nucleotide binding site [chemical binding]; other site
398580003290	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
398580003291	domain I; other site
398580003292	DNA binding groove [nucleotide binding]
398580003293	phosphate binding site [ion binding]; other site
398580003294	domain II; other site
398580003295	domain III; other site
398580003296	nucleotide binding site [chemical binding]; other site
398580003297	catalytic site [active]
398580003298	domain IV; other site
398580003299	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
398580003300	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
398580003301	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
398580003302	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
398580003303	Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758
398580003304	DNA protecting protein DprA; Region: dprA; TIGR00732
398580003305	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
398580003306	cytochrome c oxidase subunit II; Provisional; Region: COX2; MTH00140
398580003307	Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790
398580003308	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
398580003309	protoheme IX farnesyltransferase; Provisional; Region: PRK04375
398580003310	UbiA prenyltransferase family; Region: UbiA; pfam01040
398580003311	cytochrome C oxidase assembly protein; Provisional; Region: PRK05089
398580003312	Cytochrome c oxidase subunit III.  Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665
398580003313	Subunit III/VIIa interface [polypeptide binding]; other site
398580003314	Phospholipid binding site [chemical binding]; other site
398580003315	Subunit I/III interface [polypeptide binding]; other site
398580003316	Subunit III/VIb interface [polypeptide binding]; other site
398580003317	Subunit III/VIa interface; other site
398580003318	Subunit III/Vb interface [polypeptide binding]; other site
398580003319	SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662
398580003320	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
398580003321	Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560
398580003322	pyridoxal 5'-phosphate binding site [chemical binding]; other site
398580003323	catalytic residue [active]
398580003324	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
398580003325	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
398580003326	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
398580003327	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
398580003328	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
398580003329	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
398580003330	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
398580003331	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
398580003332	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
398580003333	Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195
398580003334	FAD binding pocket [chemical binding]; other site
398580003335	FAD binding motif [chemical binding]; other site
398580003336	phosphate binding motif [ion binding]; other site
398580003337	beta-alpha-beta structure motif; other site
398580003338	NAD binding pocket [chemical binding]; other site
398580003339	Bacterial protein of unknown function (DUF934); Region: DUF934; cl01526
398580003340	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
398580003341	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
398580003342	Active Sites [active]
398580003343	Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155
398580003344	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
398580003345	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
398580003346	Protein of unknown function (DUF2849); Region: DUF2849; pfam11011
398580003347	siroheme synthase; Provisional; Region: cysG; PRK10637
398580003348	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
398580003349	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
398580003350	active site
398580003351	SAM binding site [chemical binding]; other site
398580003352	homodimer interface [polypeptide binding]; other site
398580003353	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
398580003354	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
398580003355	putative DNA binding site [nucleotide binding]; other site
398580003356	putative Zn2+ binding site [ion binding]; other site
398580003357	AsnC family; Region: AsnC_trans_reg; pfam01037
398580003358	hypothetical protein; Validated; Region: PRK00029
398580003359	Uncharacterized conserved protein [Function unknown]; Region: COG0397
398580003360	nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651
398580003361	active site
398580003362	tetramer interface [polypeptide binding]; other site
398580003363	Hint domain; Region: Hint_2; pfam13403
398580003364	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562
398580003365	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
398580003366	homodimer interface [polypeptide binding]; other site
398580003367	metal binding site [ion binding]; metal-binding site
398580003368	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
398580003369	homodimer interface [polypeptide binding]; other site
398580003370	active site
398580003371	putative chemical substrate binding site [chemical binding]; other site
398580003372	metal binding site [ion binding]; metal-binding site
398580003373	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
398580003374	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666
398580003375	metal binding site [ion binding]; metal-binding site
398580003376	putative dimer interface [polypeptide binding]; other site
398580003377	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
398580003378	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
398580003379	HlyD family secretion protein; Region: HlyD_3; pfam13437
398580003380	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4649
398580003381	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
398580003382	Trp docking motif [polypeptide binding]; other site
398580003383	active site
398580003384	PQQ-like domain; Region: PQQ_2; pfam13360
398580003385	PQQ-like domain; Region: PQQ_2; pfam13360
398580003386	GTP-binding protein Der; Reviewed; Region: PRK00093
398580003387	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
398580003388	G1 box; other site
398580003389	GTP/Mg2+ binding site [chemical binding]; other site
398580003390	Switch I region; other site
398580003391	G2 box; other site
398580003392	Switch II region; other site
398580003393	G3 box; other site
398580003394	G4 box; other site
398580003395	G5 box; other site
398580003396	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
398580003397	G1 box; other site
398580003398	GTP/Mg2+ binding site [chemical binding]; other site
398580003399	Switch I region; other site
398580003400	G2 box; other site
398580003401	G3 box; other site
398580003402	Switch II region; other site
398580003403	G4 box; other site
398580003404	G5 box; other site
398580003405	Peptidase family M48; Region: Peptidase_M48; cl12018
398580003406	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
398580003407	TPR motif; other site
398580003408	binding surface
398580003409	hypothetical protein; Provisional; Region: PRK08960
398580003410	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
398580003411	pyridoxal 5'-phosphate binding site [chemical binding]; other site
398580003412	homodimer interface [polypeptide binding]; other site
398580003413	catalytic residue [active]
398580003414	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
398580003415	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
398580003416	active site
398580003417	metal binding site [ion binding]; metal-binding site
398580003418	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
398580003419	Methyltransferase domain; Region: Methyltransf_23; pfam13489
398580003420	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
398580003421	S-adenosylmethionine binding site [chemical binding]; other site
398580003422	Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009
398580003423	Transglycosylase; Region: Transgly; pfam00912
398580003424	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
398580003425	peptide chain release factor 2; Validated; Region: prfB; PRK00578
398580003426	This domain is found in peptide chain release factors; Region: PCRF; smart00937
398580003427	RF-1 domain; Region: RF-1; pfam00472
398580003428	NMT1/THI5 like; Region: NMT1; pfam09084
398580003429	Predicted integral membrane protein (DUF2189); Region: DUF2189; cl02291
398580003430	Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519
398580003431	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
398580003432	Peptidase family M23; Region: Peptidase_M23; pfam01551
398580003433	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
398580003434	dinuclear metal binding motif [ion binding]; other site
398580003435	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
398580003436	catalytic triad [active]
398580003437	Protein of unknown function; Region: DUF3971; pfam13116
398580003438	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
398580003439	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
398580003440	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
398580003441	hypothetical protein; Validated; Region: PRK09104
398580003442	Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680
398580003443	metal binding site [ion binding]; metal-binding site
398580003444	putative dimer interface [polypeptide binding]; other site
398580003445	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
398580003446	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
398580003447	substrate-cofactor binding pocket; other site
398580003448	pyridoxal 5'-phosphate binding site [chemical binding]; other site
398580003449	catalytic residue [active]
398580003450	Helix-turn-helix domain; Region: HTH_25; pfam13413
398580003451	Domain of unknown function (DUF4115); Region: DUF4115; pfam13464
398580003452	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
398580003453	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
398580003454	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
398580003455	Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030
398580003456	4-hydroxythreonine-4-phosphate dehydrogenase; Provisional; Region: pdxA; PRK05312
398580003457	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
398580003458	SurA N-terminal domain; Region: SurA_N; pfam09312
398580003459	PPIC-type PPIASE domain; Region: Rotamase_2; cl08278
398580003460	Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452
398580003461	Organic solvent tolerance protein; Region: OstA_C; pfam04453
398580003462	Predicted permeases [General function prediction only]; Region: COG0795
398580003463	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
398580003464	Predicted permeases [General function prediction only]; Region: COG0795
398580003465	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
398580003466	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
398580003467	multifunctional aminopeptidase A; Provisional; Region: PRK00913
398580003468	interface (dimer of trimers) [polypeptide binding]; other site
398580003469	Substrate-binding/catalytic site; other site
398580003470	Zn-binding sites [ion binding]; other site
398580003471	DNA polymerase III subunit chi; Validated; Region: PRK05728
398580003472	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
398580003473	Cytochrome P450; Region: p450; cl12078
398580003474	TRAP transporter, 4TM/12TM fusion protein; Region: TRAP_fused; TIGR02123
398580003475	DctM-like transporters; Region: DctM; pfam06808
398580003476	TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358
398580003477	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
398580003478	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
398580003479	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
398580003480	active site
398580003481	phosphorylation site [posttranslational modification]
398580003482	intermolecular recognition site; other site
398580003483	dimerization interface [polypeptide binding]; other site
398580003484	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
398580003485	Walker A motif; other site
398580003486	ATP binding site [chemical binding]; other site
398580003487	Walker B motif; other site
398580003488	arginine finger; other site
398580003489	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
398580003490	Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191
398580003491	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
398580003492	dimer interface [polypeptide binding]; other site
398580003493	phosphorylation site [posttranslational modification]
398580003494	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
398580003495	ATP binding site [chemical binding]; other site
398580003496	Mg2+ binding site [ion binding]; other site
398580003497	G-X-G motif; other site
398580003498	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
398580003499	Beta-lactamase; Region: Beta-lactamase; pfam00144
398580003500	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
398580003501	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
398580003502	active site
398580003503	dimerization interface [polypeptide binding]; other site
398580003504	Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
398580003505	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
398580003506	binding surface
398580003507	TPR motif; other site
398580003508	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
398580003509	HSP70 interaction site [polypeptide binding]; other site
398580003510	Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271
398580003511	Domain of unknown function (DUF4177); Region: DUF4177; pfam13783
398580003512	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
398580003513	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
398580003514	GatB domain; Region: GatB_Yqey; smart00845
398580003515	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
398580003516	N-acetyl-D-glucosamine binding site [chemical binding]; other site
398580003517	catalytic residue [active]
398580003518	MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300
398580003519	Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707
398580003520	Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707
398580003521	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
398580003522	LytTr DNA-binding domain; Region: LytTR; smart00850
398580003523	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
398580003524	FAD binding domain; Region: FAD_binding_4; pfam01565
398580003525	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450
398580003526	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
398580003527	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159
398580003528	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
398580003529	carbon-monoxide dehydrogenase, large subunit; Region: CO_dehy_Mo_lg; TIGR02416
398580003530	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; pfam01315
398580003531	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
398580003532	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
398580003533	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
398580003534	Walker A motif; other site
398580003535	ATP binding site [chemical binding]; other site
398580003536	Walker B motif; other site
398580003537	arginine finger; other site
398580003538	Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552
398580003539	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
398580003540	metal ion-dependent adhesion site (MIDAS); other site
398580003541	Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975
398580003542	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
398580003543	XdhC Rossmann domain; Region: XdhC_C; pfam13478
398580003544	2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522
398580003545	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
398580003546	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
398580003547	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
398580003548	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
398580003549	Subfamily of fatty acid CoA ligase (FACL) similar to Fum10p of Gibberella moniliformis; Region: FACL_fum10p_like; cd05926
398580003550	acyl-activating enzyme (AAE) consensus motif; other site
398580003551	acyl-activating enzyme (AAE) consensus motif; other site
398580003552	putative AMP binding site [chemical binding]; other site
398580003553	putative active site [active]
398580003554	putative CoA binding site [chemical binding]; other site
398580003555	Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772
398580003556	Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331
398580003557	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
398580003558	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
398580003559	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
398580003560	non-specific DNA binding site [nucleotide binding]; other site
398580003561	salt bridge; other site
398580003562	sequence-specific DNA binding site [nucleotide binding]; other site
398580003563	Predicted transcriptional regulator [General function prediction only]; Region: COG3800
398580003564	Domain of unknown function (DUF955); Region: DUF955; pfam06114
398580003565	Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856
398580003566	classical (c) SDRs; Region: SDR_c; cd05233
398580003567	NAD(P) binding site [chemical binding]; other site
398580003568	active site
398580003569	aminopeptidase N; Provisional; Region: pepN; PRK14015
398580003570	Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600
398580003571	active site
398580003572	Zn binding site [ion binding]; other site
398580003573	DNA photolyase; Region: DNA_photolyase; pfam00875
398580003574	FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441
398580003575	Uncharacterized protein conserved in bacteria (DUF2256); Region: DUF2256; pfam10013
398580003576	malate synthase G; Provisional; Region: PRK02999
398580003577	active site
398580003578	Domain of unknown function (DUF336); Region: DUF336; cl01249
398580003579	Peptidase C26; Region: Peptidase_C26; pfam07722
398580003580	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
398580003581	catalytic triad [active]
398580003582	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
398580003583	kynureninase; Region: kynureninase; TIGR01814
398580003584	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
398580003585	catalytic residue [active]
398580003586	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
398580003587	Phospholipid methyltransferase; Region: PEMT; cl17370
398580003588	Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304
398580003589	NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424
398580003590	ligand binding site [chemical binding]; other site
398580003591	homodimer interface [polypeptide binding]; other site
398580003592	NAD(P) binding site [chemical binding]; other site
398580003593	trimer interface B [polypeptide binding]; other site
398580003594	trimer interface A [polypeptide binding]; other site
398580003595	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
398580003596	NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; cl00566
398580003597	NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233
398580003598	Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808
398580003599	N- and C-terminal domain interface [polypeptide binding]; other site
398580003600	D-xylulose kinase; Region: XylB; TIGR01312
398580003601	active site
398580003602	MgATP binding site [chemical binding]; other site
398580003603	catalytic site [active]
398580003604	metal binding site [ion binding]; metal-binding site
398580003605	xylulose binding site [chemical binding]; other site
398580003606	homodimer interface [polypeptide binding]; other site
398580003607	DMSO reductase anchor subunit (DmsC); Region: DmsC; cl17519
398580003608	Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437
398580003609	4Fe-4S binding domain; Region: Fer4; pfam00037
398580003610	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
398580003611	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
398580003612	molybdopterin cofactor binding site; other site
398580003613	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
398580003614	The MopB_CT_2 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is...; Region: MopB_CT_2; cd02783
398580003615	putative molybdopterin cofactor binding site; other site
398580003616	Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874
398580003617	Beta-galactosidase; Region: Glyco_hydro_42; pfam02449
398580003618	A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143
398580003619	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
398580003620	2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140
398580003621	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
398580003622	active site
398580003623	intersubunit interface [polypeptide binding]; other site
398580003624	catalytic residue [active]
398580003625	2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734
398580003626	2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035
398580003627	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825
398580003628	classical (c) SDRs; Region: SDR_c; cd05233
398580003629	NAD(P) binding site [chemical binding]; other site
398580003630	active site
398580003631	dihydroxy-acid dehydratase; Validated; Region: PRK06131
398580003632	alpha-galactosidase; Provisional; Region: PRK15076
398580003633	Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297
398580003634	NAD binding site [chemical binding]; other site
398580003635	sugar binding site [chemical binding]; other site
398580003636	divalent metal binding site [ion binding]; other site
398580003637	putative tetramer (dimer of dimers) interface [polypeptide binding]; other site
398580003638	dimer interface [polypeptide binding]; other site
398580003639	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
398580003640	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
398580003641	dimer interface [polypeptide binding]; other site
398580003642	conserved gate region; other site
398580003643	putative PBP binding loops; other site
398580003644	ABC-ATPase subunit interface; other site
398580003645	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
398580003646	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
398580003647	dimer interface [polypeptide binding]; other site
398580003648	conserved gate region; other site
398580003649	putative PBP binding loops; other site
398580003650	ABC-ATPase subunit interface; other site
398580003651	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
398580003652	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
398580003653	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
398580003654	Transcriptional regulator [Transcription]; Region: IclR; COG1414
398580003655	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
398580003656	Bacterial transcriptional regulator; Region: IclR; pfam01614
398580003657	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
398580003658	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
398580003659	Walker A/P-loop; other site
398580003660	ATP binding site [chemical binding]; other site
398580003661	Q-loop/lid; other site
398580003662	ABC transporter signature motif; other site
398580003663	Walker B; other site
398580003664	D-loop; other site
398580003665	H-loop/switch region; other site
398580003666	TOBE domain; Region: TOBE_2; pfam08402
398580003667	Protein of unknown function (DUF1045); Region: DUF1045; cl15435
398580003668	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
398580003669	dimerization interface [polypeptide binding]; other site
398580003670	putative DNA binding site [nucleotide binding]; other site
398580003671	putative Zn2+ binding site [ion binding]; other site
398580003672	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
398580003673	Low molecular weight phosphatase family; Region: LMWPc; cd00115
398580003674	active site
398580003675	glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK08955
398580003676	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
398580003677	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
398580003678	Exopolysaccharide synthesis, ExoD; Region: ExoD; pfam06055
398580003679	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
398580003680	active site residue [active]
398580003681	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
398580003682	classical (c) SDRs; Region: SDR_c; cd05233
398580003683	NAD(P) binding site [chemical binding]; other site
398580003684	active site
398580003685	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
398580003686	metal-binding site [ion binding]
398580003687	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
398580003688	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
398580003689	metal-binding site [ion binding]
398580003690	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
398580003691	Soluble P-type ATPase [General function prediction only]; Region: COG4087
398580003692	Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044
398580003693	Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108
398580003694	DNA binding residues [nucleotide binding]
398580003695	dimer interface [polypeptide binding]; other site
398580003696	copper binding site [ion binding]; other site
398580003697	sodium--glutamate symport carrier (gltS); Region: gltS; TIGR00210
398580003698	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
398580003699	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
398580003700	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
398580003701	HlyD family secretion protein; Region: HlyD_3; pfam13437
398580003702	Ion channel; Region: Ion_trans_2; pfam07885
398580003703	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
398580003704	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
398580003705	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
398580003706	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
398580003707	intersubunit interface [polypeptide binding]; other site
398580003708	active site
398580003709	zinc binding site [ion binding]; other site
398580003710	Na+ binding site [ion binding]; other site
398580003711	KduI/IolB family; Region: KduI; pfam04962
398580003712	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
398580003713	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
398580003714	substrate binding site [chemical binding]; other site
398580003715	ATP binding site [chemical binding]; other site
398580003716	Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962
398580003717	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
398580003718	PYR/PP interface [polypeptide binding]; other site
398580003719	dimer interface [polypeptide binding]; other site
398580003720	TPP binding site [chemical binding]; other site
398580003721	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
398580003722	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
398580003723	TPP-binding site [chemical binding]; other site
398580003724	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
398580003725	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
398580003726	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
398580003727	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
398580003728	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
398580003729	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
398580003730	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
398580003731	Transcriptional regulators [Transcription]; Region: PurR; COG1609
398580003732	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
398580003733	DNA binding site [nucleotide binding]
398580003734	domain linker motif; other site
398580003735	Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_2; cd06278
398580003736	putative dimerization interface [polypeptide binding]; other site
398580003737	putative ligand binding site [chemical binding]; other site
398580003738	Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312
398580003739	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
398580003740	putative ligand binding site [chemical binding]; other site
398580003741	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
398580003742	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
398580003743	TM-ABC transporter signature motif; other site
398580003744	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
398580003745	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
398580003746	Walker A/P-loop; other site
398580003747	ATP binding site [chemical binding]; other site
398580003748	Q-loop/lid; other site
398580003749	ABC transporter signature motif; other site
398580003750	Walker B; other site
398580003751	D-loop; other site
398580003752	H-loop/switch region; other site
398580003753	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312
398580003754	Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718
398580003755	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
398580003756	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
398580003757	Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257
398580003758	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E family, Tungsten-containing formate dehydrogenase (W-FDH) beta subunit; composed of proteins similar to the W-FDH beta subunit of Methylobacterium extorquens. W-FDH...; Region: TRX_Fd_NuoE_W_FDH_beta; cd03082
398580003759	putative dimer interface [polypeptide binding]; other site
398580003760	[2Fe-2S] cluster binding site [ion binding]; other site
398580003761	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
398580003762	SLBB domain; Region: SLBB; pfam10531
398580003763	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928
398580003764	Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383
398580003765	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
398580003766	catalytic loop [active]
398580003767	iron binding site [ion binding]; other site
398580003768	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
398580003769	Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753
398580003770	[4Fe-4S] binding site [ion binding]; other site
398580003771	molybdopterin cofactor binding site; other site
398580003772	Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790
398580003773	molybdopterin cofactor binding site; other site
398580003774	formate--tetrahydrofolate ligase; Provisional; Region: PRK13505
398580003775	Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477
398580003776	Potassium binding sites [ion binding]; other site
398580003777	Cesium cation binding sites [ion binding]; other site
398580003778	Chorismate mutase type II; Region: CM_2; smart00830
398580003779	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14188
398580003780	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
398580003781	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
398580003782	homodimer interface [polypeptide binding]; other site
398580003783	NADP binding site [chemical binding]; other site
398580003784	substrate binding site [chemical binding]; other site
398580003785	Protein of unknown function (DUF3422); Region: DUF3422; pfam11902
398580003786	Predicted transporter component [General function prediction only]; Region: COG2391
398580003787	Sulphur transport; Region: Sulf_transp; pfam04143
398580003788	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
398580003789	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666
398580003790	metal binding site [ion binding]; metal-binding site
398580003791	putative dimer interface [polypeptide binding]; other site
398580003792	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
398580003793	catalytic triad [active]
398580003794	molybdenum cofactor biosynthesis protein A; Provisional; Region: PRK13361
398580003795	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
398580003796	FeS/SAM binding site; other site
398580003797	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
398580003798	DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713
398580003799	A new structural DNA glycosylase; Region: AlkD_like; cd06561
398580003800	active site
398580003801	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
398580003802	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
398580003803	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
398580003804	glutaminase active site [active]
398580003805	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
398580003806	dimer interface [polypeptide binding]; other site
398580003807	active site
398580003808	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
398580003809	dimer interface [polypeptide binding]; other site
398580003810	active site
398580003811	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14353
398580003812	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
398580003813	active site
398580003814	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
398580003815	active site
398580003816	substrate binding site [chemical binding]; other site
398580003817	CoA binding site [chemical binding]; other site
398580003818	phosphoglycolate phosphatase; Provisional; Region: PRK13222
398580003819	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
398580003820	active site
398580003821	motif I; other site
398580003822	motif II; other site
398580003823	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
398580003824	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
398580003825	catalytic residue [active]
398580003826	isovaleryl-CoA dehydrogenase; Region: PLN02519
398580003827	Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156
398580003828	substrate binding site [chemical binding]; other site
398580003829	FAD binding site [chemical binding]; other site
398580003830	catalytic base [active]
398580003831	Outer membrane protein W [Cell envelope biogenesis, outer membrane]; Region: OmpW; COG3047
398580003832	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
398580003833	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
398580003834	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
398580003835	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
398580003836	ATP-grasp domain; Region: ATP-grasp_4; cl17255
398580003837	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
398580003838	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
398580003839	carboxyltransferase (CT) interaction site; other site
398580003840	biotinylation site [posttranslational modification]; other site
398580003841	GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046
398580003842	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
398580003843	putative C-terminal domain interface [polypeptide binding]; other site
398580003844	putative GSH binding site (G-site) [chemical binding]; other site
398580003845	putative dimer interface [polypeptide binding]; other site
398580003846	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
398580003847	N-terminal domain interface [polypeptide binding]; other site
398580003848	3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938
398580003849	active site
398580003850	catalytic residues [active]
398580003851	metal binding site [ion binding]; metal-binding site
398580003852	enoyl-CoA hydratase; Provisional; Region: PRK07468
398580003853	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
398580003854	substrate binding site [chemical binding]; other site
398580003855	oxyanion hole (OAH) forming residues; other site
398580003856	trimer interface [polypeptide binding]; other site
398580003857	NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602
398580003858	NADH dehydrogenase subunit B; Validated; Region: PRK06411
398580003859	NADH dehydrogenase subunit C; Provisional; Region: PRK06074
398580003860	NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961
398580003861	NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649
398580003862	NADH dehydrogenase subunit D; Validated; Region: PRK06075
398580003863	NADH dehydrogenase subunit E; Provisional; Region: PRK12373
398580003864	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
398580003865	putative dimer interface [polypeptide binding]; other site
398580003866	[2Fe-2S] cluster binding site [ion binding]; other site
398580003867	Uncharacterized conserved protein [Function unknown]; Region: COG3743
398580003868	Uncharacterized conserved protein [Function unknown]; Region: COG3743
398580003869	NADH dehydrogenase I subunit F; Provisional; Region: PRK13596
398580003870	SLBB domain; Region: SLBB; pfam10531
398580003871	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928
398580003872	Domain of unknown function (DUF3291); Region: DUF3291; pfam11695
398580003873	NADH dehydrogenase subunit G; Validated; Region: PRK09130
398580003874	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
398580003875	catalytic loop [active]
398580003876	iron binding site [ion binding]; other site
398580003877	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
398580003878	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
398580003879	molybdopterin cofactor binding site; other site
398580003880	Domain of unknown function (DUF1982); Region: DUF1982; pfam09326
398580003881	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
398580003882	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
398580003883	NADH dehydrogenase subunit I; Provisional; Region: PRK05888
398580003884	4Fe-4S binding domain; Region: Fer4; pfam00037
398580003885	4Fe-4S binding domain; Region: Fer4; pfam00037
398580003886	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
398580003887	NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638
398580003888	NADH dehydrogenase subunit J; Provisional; Region: PRK06433
398580003889	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
398580003890	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
398580003891	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
398580003892	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
398580003893	NADH dehydrogenase subunit 5 C-terminus; Region: NADH5_C; pfam06455
398580003894	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
398580003895	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
398580003896	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
398580003897	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
398580003898	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
398580003899	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
398580003900	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
398580003901	pantothenate kinase; Reviewed; Region: PRK13318
398580003902	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
398580003903	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
398580003904	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
398580003905	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
398580003906	DEAD-like helicases superfamily; Region: DEXDc; smart00487
398580003907	ATP binding site [chemical binding]; other site
398580003908	Mg++ binding site [ion binding]; other site
398580003909	motif III; other site
398580003910	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
398580003911	nucleotide binding region [chemical binding]; other site
398580003912	ATP-binding site [chemical binding]; other site
398580003913	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
398580003914	binding surface
398580003915	TPR motif; other site
398580003916	TPR repeat; Region: TPR_11; pfam13414
398580003917	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
398580003918	binding surface
398580003919	TPR motif; other site
398580003920	TPR repeat; Region: TPR_11; pfam13414
398580003921	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
398580003922	binding surface
398580003923	TPR motif; other site
398580003924	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
398580003925	binding surface
398580003926	TPR motif; other site
398580003927	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
398580003928	TPR motif; other site
398580003929	binding surface
398580003930	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
398580003931	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
398580003932	G1 box; other site
398580003933	putative GEF interaction site [polypeptide binding]; other site
398580003934	GTP/Mg2+ binding site [chemical binding]; other site
398580003935	Switch I region; other site
398580003936	G2 box; other site
398580003937	G3 box; other site
398580003938	Switch II region; other site
398580003939	G4 box; other site
398580003940	G5 box; other site
398580003941	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
398580003942	SnoaL-like domain; Region: SnoaL_2; pfam12680
398580003943	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
398580003944	Ligand Binding Site [chemical binding]; other site
398580003945	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
398580003946	Ligand Binding Site [chemical binding]; other site
398580003947	short chain dehydrogenase; Provisional; Region: PRK08339
398580003948	putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344
398580003949	putative NAD(P) binding site [chemical binding]; other site
398580003950	putative active site [active]
398580003951	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
398580003952	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
398580003953	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
398580003954	Walker A/P-loop; other site
398580003955	ATP binding site [chemical binding]; other site
398580003956	Q-loop/lid; other site
398580003957	ABC transporter signature motif; other site
398580003958	Walker B; other site
398580003959	D-loop; other site
398580003960	H-loop/switch region; other site
398580003961	TOBE domain; Region: TOBE_2; pfam08402
398580003962	HTH domain; Region: HTH_11; pfam08279
398580003963	WYL domain; Region: WYL; pfam13280
398580003964	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
398580003965	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
398580003966	Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805
398580003967	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607
398580003968	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
398580003969	Walker A motif; other site
398580003970	ATP binding site [chemical binding]; other site
398580003971	Walker B motif; other site
398580003972	Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483
398580003973	catalytic motif [active]
398580003974	Catalytic residue [active]
398580003975	Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095
398580003976	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
398580003977	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
398580003978	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
398580003979	ABC transporter; Region: ABC_tran_2; pfam12848
398580003980	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
398580003981	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
398580003982	active site
398580003983	multimer interface [polypeptide binding]; other site
398580003984	TfoX C-terminal domain; Region: TfoX_C; pfam04994
398580003985	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
398580003986	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
398580003987	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
398580003988	dimer interface [polypeptide binding]; other site
398580003989	conserved gate region; other site
398580003990	putative PBP binding loops; other site
398580003991	ABC-ATPase subunit interface; other site
398580003992	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
398580003993	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
398580003994	dimer interface [polypeptide binding]; other site
398580003995	conserved gate region; other site
398580003996	putative PBP binding loops; other site
398580003997	ABC-ATPase subunit interface; other site
398580003998	Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408
398580003999	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
398580004000	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
398580004001	Walker A/P-loop; other site
398580004002	ATP binding site [chemical binding]; other site
398580004003	Q-loop/lid; other site
398580004004	ABC transporter signature motif; other site
398580004005	Walker B; other site
398580004006	D-loop; other site
398580004007	H-loop/switch region; other site
398580004008	TOBE domain; Region: TOBE_2; pfam08402
398580004009	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
398580004010	classical (c) SDRs; Region: SDR_c; cd05233
398580004011	NAD(P) binding site [chemical binding]; other site
398580004012	active site
398580004013	Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172
398580004014	DUF35 OB-fold domain; Region: DUF35; pfam01796
398580004015	SnoaL-like domain; Region: SnoaL_2; pfam12680
398580004016	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
398580004017	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
398580004018	FAD binding domain; Region: FAD_binding_4; pfam01565
398580004019	dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749
398580004020	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
398580004021	dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318
398580004022	Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain.  DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940
398580004023	homodimer interface [polypeptide binding]; other site
398580004024	active site
398580004025	FMN binding site [chemical binding]; other site
398580004026	substrate binding site [chemical binding]; other site
398580004027	4Fe-4S binding domain; Region: Fer4_6; pfam12837
398580004028	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
398580004029	YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362
398580004030	beta alanine--pyruvate transaminase; Provisional; Region: PRK09221
398580004031	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
398580004032	inhibitor-cofactor binding pocket; inhibition site
398580004033	pyridoxal 5'-phosphate binding site [chemical binding]; other site
398580004034	catalytic residue [active]
398580004035	allantoate amidohydrolase; Reviewed; Region: PRK12893
398580004036	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
398580004037	active site
398580004038	metal binding site [ion binding]; metal-binding site
398580004039	dimer interface [polypeptide binding]; other site
398580004040	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214
398580004041	intersubunit interface [polypeptide binding]; other site
398580004042	active site
398580004043	Zn2+ binding site [ion binding]; other site
398580004044	phenylhydantoinase; Validated; Region: PRK08323
398580004045	D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314
398580004046	tetramer interface [polypeptide binding]; other site
398580004047	active site
398580004048	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
398580004049	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
398580004050	Walker A/P-loop; other site
398580004051	ATP binding site [chemical binding]; other site
398580004052	Q-loop/lid; other site
398580004053	ABC transporter signature motif; other site
398580004054	Walker B; other site
398580004055	D-loop; other site
398580004056	H-loop/switch region; other site
398580004057	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
398580004058	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
398580004059	dimer interface [polypeptide binding]; other site
398580004060	conserved gate region; other site
398580004061	putative PBP binding loops; other site
398580004062	ABC-ATPase subunit interface; other site
398580004063	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
398580004064	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
398580004065	dimer interface [polypeptide binding]; other site
398580004066	conserved gate region; other site
398580004067	putative PBP binding loops; other site
398580004068	ABC-ATPase subunit interface; other site
398580004069	NMT1/THI5 like; Region: NMT1; pfam09084
398580004070	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
398580004071	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; Region: PLPDE_III_ODC; cd00622
398580004072	dimer interface [polypeptide binding]; other site
398580004073	active site
398580004074	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
398580004075	catalytic residues [active]
398580004076	substrate binding site [chemical binding]; other site
398580004077	Creatinine amidohydrolase; Region: Creatininase; pfam02633
398580004078	oxidase reductase; Provisional; Region: PTZ00273
398580004079	non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226
398580004080	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171
398580004081	Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249
398580004082	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
398580004083	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
398580004084	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
398580004085	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
398580004086	FAD binding domain; Region: FAD_binding_4; pfam01565
398580004087	cytosine deaminase-like protein; Validated; Region: PRK07583
398580004088	Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293
398580004089	active site
398580004090	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
398580004091	Binding-protein-dependent transport system inner membrane component; Region: BPD_transp_1; pfam00528
398580004092	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
398580004093	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
398580004094	Walker A/P-loop; other site
398580004095	ATP binding site [chemical binding]; other site
398580004096	Q-loop/lid; other site
398580004097	ABC transporter signature motif; other site
398580004098	Walker B; other site
398580004099	D-loop; other site
398580004100	H-loop/switch region; other site
398580004101	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
398580004102	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
398580004103	homotrimer interaction site [polypeptide binding]; other site
398580004104	putative active site [active]
398580004105	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
398580004106	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
398580004107	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
398580004108	Walker A motif; other site
398580004109	ATP binding site [chemical binding]; other site
398580004110	Walker B motif; other site
398580004111	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
398580004112	Clp protease; Region: CLP_protease; pfam00574
398580004113	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
398580004114	oligomer interface [polypeptide binding]; other site
398580004115	active site residues [active]
398580004116	Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415
398580004117	NADH dehydrogenase; Validated; Region: PRK08183
398580004118	mce related protein; Region: MCE; pfam02470
398580004119	Uncharacterized protein conserved in bacteria (DUF2155); Region: DUF2155; pfam09923
398580004120	leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301
398580004121	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
398580004122	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
398580004123	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
398580004124	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
398580004125	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
398580004126	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
398580004127	carboxyltransferase (CT) interaction site; other site
398580004128	biotinylation site [posttranslational modification]; other site
398580004129	Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: fatty_acyltransferase_like; cd01846
398580004130	active site
398580004131	catalytic triad [active]
398580004132	oxyanion hole [active]
398580004133	DsrE/DsrF-like family; Region: DrsE; pfam02635
398580004134	acetyl-CoA synthetase; Provisional; Region: PRK00174
398580004135	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
398580004136	active site
398580004137	CoA binding site [chemical binding]; other site
398580004138	acyl-activating enzyme (AAE) consensus motif; other site
398580004139	AMP binding site [chemical binding]; other site
398580004140	acetate binding site [chemical binding]; other site
398580004141	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
398580004142	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
398580004143	Walker A/P-loop; other site
398580004144	ATP binding site [chemical binding]; other site
398580004145	Q-loop/lid; other site
398580004146	ABC transporter signature motif; other site
398580004147	Walker B; other site
398580004148	D-loop; other site
398580004149	H-loop/switch region; other site
398580004150	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
398580004151	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
398580004152	Walker A/P-loop; other site
398580004153	ATP binding site [chemical binding]; other site
398580004154	Q-loop/lid; other site
398580004155	ABC transporter signature motif; other site
398580004156	Walker B; other site
398580004157	D-loop; other site
398580004158	H-loop/switch region; other site
398580004159	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
398580004160	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
398580004161	TM-ABC transporter signature motif; other site
398580004162	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
398580004163	TM-ABC transporter signature motif; other site
398580004164	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
398580004165	Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327
398580004166	putative ligand binding site [chemical binding]; other site
398580004167	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
398580004168	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
398580004169	non-specific DNA binding site [nucleotide binding]; other site
398580004170	salt bridge; other site
398580004171	sequence-specific DNA binding site [nucleotide binding]; other site
398580004172	Predicted transcriptional regulator [General function prediction only]; Region: COG3800
398580004173	Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856
398580004174	Response regulator receiver domain; Region: Response_reg; pfam00072
398580004175	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
398580004176	active site
398580004177	phosphorylation site [posttranslational modification]
398580004178	intermolecular recognition site; other site
398580004179	dimerization interface [polypeptide binding]; other site
398580004180	Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591
398580004181	Na binding site [ion binding]; other site
398580004182	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
398580004183	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
398580004184	dimer interface [polypeptide binding]; other site
398580004185	phosphorylation site [posttranslational modification]
398580004186	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
398580004187	ATP binding site [chemical binding]; other site
398580004188	Mg2+ binding site [ion binding]; other site
398580004189	G-X-G motif; other site
398580004190	Flagellar motor switch protein [Cell motility and secretion]; Region: FliM; COG1868
398580004191	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
398580004192	Putative phosphatase (DUF442); Region: DUF442; cl17385
398580004193	Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755
398580004194	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
398580004195	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
398580004196	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
398580004197	dimer interface [polypeptide binding]; other site
398580004198	conserved gate region; other site
398580004199	putative PBP binding loops; other site
398580004200	ABC-ATPase subunit interface; other site
398580004201	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
398580004202	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
398580004203	dimer interface [polypeptide binding]; other site
398580004204	conserved gate region; other site
398580004205	putative PBP binding loops; other site
398580004206	ABC-ATPase subunit interface; other site
398580004207	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
398580004208	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
398580004209	Walker A/P-loop; other site
398580004210	ATP binding site [chemical binding]; other site
398580004211	Q-loop/lid; other site
398580004212	ABC transporter signature motif; other site
398580004213	Walker B; other site
398580004214	D-loop; other site
398580004215	H-loop/switch region; other site
398580004216	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
398580004217	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
398580004218	Uncharacterized protein conserved in bacteria (DUF2312); Region: DUF2312; pfam10073
398580004219	Periplasmic sugar-binding component of uncharacterized ABC-type transport systems that are members of the pentose/hexose sugar-binding protein family of the type I periplasmic binding protein superfamily; Region: PBP1_ABC_sugar_binding_like_1; cd06300
398580004220	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
398580004221	putative ligand binding site [chemical binding]; other site
398580004222	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
398580004223	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
398580004224	Walker A/P-loop; other site
398580004225	ATP binding site [chemical binding]; other site
398580004226	Q-loop/lid; other site
398580004227	ABC transporter signature motif; other site
398580004228	Walker B; other site
398580004229	D-loop; other site
398580004230	H-loop/switch region; other site
398580004231	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
398580004232	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
398580004233	TM-ABC transporter signature motif; other site
398580004234	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
398580004235	TM-ABC transporter signature motif; other site
398580004236	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
398580004237	Streptomyces aureofaciens putative aldehyde dehydrogenase AldA (AAD23400)-like; Region: ALDH_AldA-AAD23400; cd07106
398580004238	NAD(P) binding site [chemical binding]; other site
398580004239	catalytic residues [active]
398580004240	fumarate hydratase; Provisional; Region: PRK15389
398580004241	Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681
398580004242	Fumarase C-terminus; Region: Fumerase_C; pfam05683
398580004243	Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051
398580004244	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
398580004245	choline dehydrogenase; Validated; Region: PRK02106
398580004246	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
398580004247	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
398580004248	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
398580004249	putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR), subgroup 3, classical (c) SDR; Region: BKR_3_SDR_c; cd05345
398580004250	putative NAD(P) binding site [chemical binding]; other site
398580004251	active site
398580004252	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
398580004253	Uncharacterized Saccharopolyspora spinosa aldehyde dehydrogenase (AAS00426)-like; Region: ALDH_AAS00426; cd07109
398580004254	NAD(P) binding site [chemical binding]; other site
398580004255	catalytic residues [active]
398580004256	catalytic residues [active]
398580004257	Transcriptional regulator [Transcription]; Region: LysR; COG0583
398580004258	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
398580004259	The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433
398580004260	putative dimerization interface [polypeptide binding]; other site
398580004261	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
398580004262	CoA-transferase family III; Region: CoA_transf_3; pfam02515
398580004263	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
398580004264	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
398580004265	Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842
398580004266	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
398580004267	dimer interface [polypeptide binding]; other site
398580004268	conserved gate region; other site
398580004269	putative PBP binding loops; other site
398580004270	ABC-ATPase subunit interface; other site
398580004271	choline ABC transporter, ATP-binding protein; Region: ABC_choXWV_ATP; TIGR03415
398580004272	ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294
398580004273	Walker A/P-loop; other site
398580004274	ATP binding site [chemical binding]; other site
398580004275	Q-loop/lid; other site
398580004276	ABC transporter signature motif; other site
398580004277	Walker B; other site
398580004278	D-loop; other site
398580004279	H-loop/switch region; other site
398580004280	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
398580004281	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891
398580004282	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
398580004283	D-cysteine desulfhydrase; Validated; Region: PRK03910
398580004284	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
398580004285	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
398580004286	catalytic residue [active]
398580004287	Transcriptional regulator [Transcription]; Region: LysR; COG0583
398580004288	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
398580004289	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
398580004290	dimerization interface [polypeptide binding]; other site
398580004291	Dyp-type peroxidase family; Region: Dyp_perox; cl01067
398580004292	TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358
398580004293	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
398580004294	TRAP-type uncharacterized transport system, fused permease components [General function prediction only]; Region: COG4666
398580004295	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274
398580004296	Domain of unknown function (DUF3394); Region: DUF3394; pfam11874
398580004297	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
398580004298	Ligand Binding Site [chemical binding]; other site
398580004299	hypothetical protein; Provisional; Region: PRK07483
398580004300	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
398580004301	inhibitor-cofactor binding pocket; inhibition site
398580004302	pyridoxal 5'-phosphate binding site [chemical binding]; other site
398580004303	catalytic residue [active]
398580004304	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
398580004305	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
398580004306	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
398580004307	N-terminal plug; other site
398580004308	ligand-binding site [chemical binding]; other site
398580004309	NnrS protein; Region: NnrS; pfam05940
398580004310	NnrS protein; Region: NnrS; pfam05940
398580004311	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
398580004312	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
398580004313	Walker A/P-loop; other site
398580004314	ATP binding site [chemical binding]; other site
398580004315	Q-loop/lid; other site
398580004316	ABC transporter signature motif; other site
398580004317	Walker B; other site
398580004318	D-loop; other site
398580004319	H-loop/switch region; other site
398580004320	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
398580004321	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
398580004322	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
398580004323	substrate binding pocket [chemical binding]; other site
398580004324	membrane-bound complex binding site; other site
398580004325	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832
398580004326	HTH-like domain; Region: HTH_21; pfam13276
398580004327	Integrase core domain; Region: rve; pfam00665
398580004328	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
398580004329	ATP binding site [chemical binding]; other site
398580004330	putative Mg++ binding site [ion binding]; other site
398580004331	Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; pfam09832
398580004332	50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278
398580004333	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
398580004334	Uncharacterized conserved protein [Function unknown]; Region: COG3743
398580004335	50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278
398580004336	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
398580004337	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
398580004338	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
398580004339	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
398580004340	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
398580004341	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
398580004342	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
398580004343	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
398580004344	GTPase CgtA; Reviewed; Region: obgE; PRK12299
398580004345	GTP1/OBG; Region: GTP1_OBG; pfam01018
398580004346	Obg GTPase; Region: Obg; cd01898
398580004347	G1 box; other site
398580004348	GTP/Mg2+ binding site [chemical binding]; other site
398580004349	Switch I region; other site
398580004350	G2 box; other site
398580004351	G3 box; other site
398580004352	Switch II region; other site
398580004353	G4 box; other site
398580004354	G5 box; other site
398580004355	gamma-glutamyl kinase; Provisional; Region: PRK05429
398580004356	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
398580004357	nucleotide binding site [chemical binding]; other site
398580004358	homotetrameric interface [polypeptide binding]; other site
398580004359	putative phosphate binding site [ion binding]; other site
398580004360	putative allosteric binding site; other site
398580004361	PUA domain; Region: PUA; pfam01472
398580004362	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
398580004363	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
398580004364	putative catalytic cysteine [active]
398580004365	Uncharacterized protein conserved in bacteria (DUF2328); Region: DUF2328; pfam10090
398580004366	Protein of unknown function (DUF3553); Region: DUF3553; pfam12073
398580004367	Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496
398580004368	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
398580004369	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
398580004370	putative acyl-acceptor binding pocket; other site
398580004371	glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710
398580004372	active site
398580004373	HIGH motif; other site
398580004374	nucleotide binding site [chemical binding]; other site
398580004375	active site
398580004376	KMSKS motif; other site
398580004377	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
398580004378	Glucose inhibited division protein A; Region: GIDA; pfam01134
398580004379	DNA gyrase subunit A; Validated; Region: PRK05560
398580004380	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
398580004381	CAP-like domain; other site
398580004382	active site
398580004383	primary dimer interface [polypeptide binding]; other site
398580004384	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
398580004385	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
398580004386	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
398580004387	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
398580004388	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
398580004389	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
398580004390	Usg-like family; Region: Usg; pfam06233
398580004391	Disulfide bond formation protein DsbB; Region: DsbB; pfam02600
398580004392	Exopolysaccharide synthesis, ExoD; Region: ExoD; pfam06055
398580004393	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
398580004394	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290
398580004395	DctM-like transporters; Region: DctM; pfam06808
398580004396	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
398580004397	GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182
398580004398	Ligand binding site; other site
398580004399	metal-binding site
398580004400	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
398580004401	hydroxyglutarate oxidase; Provisional; Region: PRK11728
398580004402	Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404
398580004403	Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893
398580004404	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
398580004405	BCCT family transporter; Region: BCCT; pfam02028
398580004406	BCCT family transporter; Region: BCCT; pfam02028
398580004407	glutathione transporter ATP-binding protein; Provisional; Region: PRK10261
398580004408	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
398580004409	Walker A/P-loop; other site
398580004410	ATP binding site [chemical binding]; other site
398580004411	Q-loop/lid; other site
398580004412	ABC transporter signature motif; other site
398580004413	Walker B; other site
398580004414	D-loop; other site
398580004415	H-loop/switch region; other site
398580004416	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
398580004417	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
398580004418	Walker A/P-loop; other site
398580004419	ATP binding site [chemical binding]; other site
398580004420	Q-loop/lid; other site
398580004421	ABC transporter signature motif; other site
398580004422	Walker B; other site
398580004423	D-loop; other site
398580004424	H-loop/switch region; other site
398580004425	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
398580004426	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
398580004427	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
398580004428	conserved gate region; other site
398580004429	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
398580004430	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
398580004431	dimer interface [polypeptide binding]; other site
398580004432	conserved gate region; other site
398580004433	putative PBP binding loops; other site
398580004434	ABC-ATPase subunit interface; other site
398580004435	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
398580004436	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503
398580004437	Helix-turn-helix domain; Region: HTH_18; pfam12833
398580004438	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
398580004439	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
398580004440	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
398580004441	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
398580004442	putative nucleotide binding site [chemical binding]; other site
398580004443	uridine monophosphate binding site [chemical binding]; other site
398580004444	homohexameric interface [polypeptide binding]; other site
398580004445	ribosome recycling factor; Reviewed; Region: frr; PRK00083
398580004446	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
398580004447	hinge region; other site
398580004448	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
398580004449	Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255
398580004450	catalytic residue [active]
398580004451	putative FPP diphosphate  binding site; other site
398580004452	putative FPP binding hydrophobic cleft; other site
398580004453	dimer interface [polypeptide binding]; other site
398580004454	putative IPP diphosphate binding site; other site
398580004455	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
398580004456	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
398580004457	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
398580004458	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
398580004459	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
398580004460	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
398580004461	RIP metalloprotease RseP; Region: TIGR00054
398580004462	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
398580004463	active site
398580004464	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117
398580004465	protein binding site [polypeptide binding]; other site
398580004466	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
398580004467	protein binding site [polypeptide binding]; other site
398580004468	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
398580004469	putative substrate binding region [chemical binding]; other site
398580004470	outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303
398580004471	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
398580004472	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
398580004473	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
398580004474	Surface antigen; Region: Bac_surface_Ag; pfam01103
398580004475	Outer membrane protein (OmpH-like); Region: OmpH; pfam03938
398580004476	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
398580004477	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
398580004478	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
398580004479	active site
398580004480	Protein of unknown function (DUF1009); Region: DUF1009; pfam06230
398580004481	lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025
398580004482	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
398580004483	Lamin Tail Domain; Region: LTD; pfam00932
398580004484	Hint domain; Region: Hint_2; pfam13403
398580004485	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
398580004486	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
398580004487	Ligand Binding Site [chemical binding]; other site
398580004488	Protein of unknown function (DUF1153); Region: DUF1153; pfam06627
398580004489	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
398580004490	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
398580004491	active site
398580004492	phosphorylation site [posttranslational modification]
398580004493	intermolecular recognition site; other site
398580004494	dimerization interface [polypeptide binding]; other site
398580004495	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
398580004496	DNA binding site [nucleotide binding]
398580004497	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
398580004498	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
398580004499	nucleotide binding pocket [chemical binding]; other site
398580004500	K-X-D-G motif; other site
398580004501	catalytic site [active]
398580004502	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
398580004503	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
398580004504	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
398580004505	Dimer interface [polypeptide binding]; other site
398580004506	BRCT sequence motif; other site
398580004507	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
398580004508	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
398580004509	generic binding surface II; other site
398580004510	ssDNA binding site; other site
398580004511	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
398580004512	ATP binding site [chemical binding]; other site
398580004513	putative Mg++ binding site [ion binding]; other site
398580004514	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
398580004515	nucleotide binding region [chemical binding]; other site
398580004516	ATP-binding site [chemical binding]; other site
398580004517	Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317
398580004518	Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460
398580004519	active site
398580004520	Zn binding site [ion binding]; other site
398580004521	Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612
398580004522	Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852
398580004523	rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565
398580004524	SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307
398580004525	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
398580004526	thiamine phosphate binding site [chemical binding]; other site
398580004527	active site
398580004528	pyrophosphate binding site [ion binding]; other site
398580004529	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
398580004530	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
398580004531	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
398580004532	trimerization site [polypeptide binding]; other site
398580004533	active site
398580004534	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454
398580004535	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
398580004536	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
398580004537	TM-ABC transporter signature motif; other site
398580004538	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
398580004539	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
398580004540	TM-ABC transporter signature motif; other site
398580004541	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
398580004542	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
398580004543	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
398580004544	Walker A/P-loop; other site
398580004545	ATP binding site [chemical binding]; other site
398580004546	Q-loop/lid; other site
398580004547	ABC transporter signature motif; other site
398580004548	Walker B; other site
398580004549	D-loop; other site
398580004550	H-loop/switch region; other site
398580004551	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
398580004552	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
398580004553	Walker A/P-loop; other site
398580004554	ATP binding site [chemical binding]; other site
398580004555	Q-loop/lid; other site
398580004556	ABC transporter signature motif; other site
398580004557	Walker B; other site
398580004558	D-loop; other site
398580004559	H-loop/switch region; other site
398580004560	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
398580004561	Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_11; cd06346
398580004562	putative ligand binding site [chemical binding]; other site
398580004563	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
398580004564	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
398580004565	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
398580004566	AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136
398580004567	conserved cys residue [active]
398580004568	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
398580004569	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
398580004570	Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474
398580004571	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5388
398580004572	PAS domain; Region: PAS_5; pfam07310
398580004573	hypothetical protein; Provisional; Region: PRK11820
398580004574	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
398580004575	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
398580004576	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
398580004577	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
398580004578	catalytic site [active]
398580004579	G-X2-G-X-G-K; other site
398580004580	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
398580004581	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
398580004582	trimer interface [polypeptide binding]; other site
398580004583	putative metal binding site [ion binding]; other site
398580004584	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
398580004585	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
398580004586	dimer interface [polypeptide binding]; other site
398580004587	phosphorylation site [posttranslational modification]
398580004588	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
398580004589	ATP binding site [chemical binding]; other site
398580004590	Mg2+ binding site [ion binding]; other site
398580004591	G-X-G motif; other site
398580004592	PBP superfamily domain; Region: PBP_like_2; pfam12849
398580004593	Phosphate ATP-binding cassette transporter; Region: DUF3708; pfam12501
398580004594	phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138
398580004595	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
398580004596	dimer interface [polypeptide binding]; other site
398580004597	conserved gate region; other site
398580004598	putative PBP binding loops; other site
398580004599	ABC-ATPase subunit interface; other site
398580004600	Domain of unknown function (DUF3333); Region: DUF3333; pfam11812
398580004601	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
398580004602	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
398580004603	dimer interface [polypeptide binding]; other site
398580004604	conserved gate region; other site
398580004605	putative PBP binding loops; other site
398580004606	ABC-ATPase subunit interface; other site
398580004607	phosphate transporter ATP-binding protein; Provisional; Region: PRK14235
398580004608	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
398580004609	Walker A/P-loop; other site
398580004610	ATP binding site [chemical binding]; other site
398580004611	Q-loop/lid; other site
398580004612	ABC transporter signature motif; other site
398580004613	Walker B; other site
398580004614	D-loop; other site
398580004615	H-loop/switch region; other site
398580004616	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
398580004617	PhoU domain; Region: PhoU; pfam01895
398580004618	PhoU domain; Region: PhoU; pfam01895
398580004619	phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154
398580004620	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
398580004621	active site
398580004622	phosphorylation site [posttranslational modification]
398580004623	intermolecular recognition site; other site
398580004624	dimerization interface [polypeptide binding]; other site
398580004625	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
398580004626	DNA binding site [nucleotide binding]
398580004627	K+-dependent Na+/Ca+ exchanger related-protein; Region: TIGR00367
398580004628	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
398580004629	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
398580004630	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
398580004631	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
398580004632	protein binding site [polypeptide binding]; other site
398580004633	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
398580004634	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
398580004635	active site
398580004636	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
398580004637	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
398580004638	Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209
398580004639	active site
398580004640	nucleophile elbow; other site
398580004641	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
398580004642	3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963
398580004643	NAD(P) binding site [chemical binding]; other site
398580004644	active site
398580004645	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
398580004646	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497
398580004647	Uncharacterized conserved protein [Function unknown]; Region: COG2928
398580004648	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
398580004649	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
398580004650	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
398580004651	rRNA interaction site [nucleotide binding]; other site
398580004652	S8 interaction site; other site
398580004653	putative laminin-1 binding site; other site
398580004654	elongation factor Ts; Provisional; Region: tsf; PRK09377
398580004655	UBA/TS-N domain; Region: UBA; pfam00627
398580004656	Elongation factor TS; Region: EF_TS; pfam00889
398580004657	Elongation factor TS; Region: EF_TS; pfam00889
398580004658	Autoinducer binding domain; Region: Autoind_bind; pfam03472
398580004659	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
398580004660	DNA binding residues [nucleotide binding]
398580004661	dimerization interface [polypeptide binding]; other site
398580004662	Dehydroquinase class II; Region: DHquinase_II; pfam01220
398580004663	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
398580004664	trimer interface [polypeptide binding]; other site
398580004665	active site
398580004666	dimer interface [polypeptide binding]; other site
398580004667	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395
398580004668	putative aldolase; Validated; Region: PRK08130
398580004669	intersubunit interface [polypeptide binding]; other site
398580004670	active site
398580004671	Zn2+ binding site [ion binding]; other site
398580004672	Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622
398580004673	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
398580004674	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
398580004675	non-specific DNA binding site [nucleotide binding]; other site
398580004676	salt bridge; other site
398580004677	sequence-specific DNA binding site [nucleotide binding]; other site
398580004678	Cupin domain; Region: Cupin_2; pfam07883
398580004679	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
398580004680	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
398580004681	acyl-activating enzyme (AAE) consensus motif; other site
398580004682	AMP binding site [chemical binding]; other site
398580004683	active site
398580004684	CoA binding site [chemical binding]; other site
398580004685	Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761
398580004686	DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024
398580004687	catalytic residues [active]
398580004688	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
398580004689	bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102
398580004690	putative substrate translocation pore; other site
398580004691	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
398580004692	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
398580004693	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
398580004694	ATP binding site [chemical binding]; other site
398580004695	putative Mg++ binding site [ion binding]; other site
398580004696	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
398580004697	nucleotide binding region [chemical binding]; other site
398580004698	ATP-binding site [chemical binding]; other site
398580004699	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
398580004700	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823
398580004701	dimer interface [polypeptide binding]; other site
398580004702	active site
398580004703	aspartate-rich active site metal binding site; other site
398580004704	allosteric magnesium binding site [ion binding]; other site
398580004705	Schiff base residues; other site
398580004706	The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cd11524
398580004707	putative amphipathic alpha helix; other site
398580004708	Protein related to penicillin acylase [General function prediction only]; Region: COG2366
398580004709	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
398580004710	Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747
398580004711	active site
398580004712	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
398580004713	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
398580004714	HflX GTPase family; Region: HflX; cd01878
398580004715	G1 box; other site
398580004716	GTP/Mg2+ binding site [chemical binding]; other site
398580004717	Switch I region; other site
398580004718	G2 box; other site
398580004719	G3 box; other site
398580004720	Switch II region; other site
398580004721	G4 box; other site
398580004722	G5 box; other site
398580004723	bacterial Hfq-like; Region: Hfq; cd01716
398580004724	hexamer interface [polypeptide binding]; other site
398580004725	Sm1 motif; other site
398580004726	RNA binding site [nucleotide binding]; other site
398580004727	Sm2 motif; other site
398580004728	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
398580004729	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
398580004730	potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496
398580004731	TrkA-N domain; Region: TrkA_N; pfam02254
398580004732	TrkA-C domain; Region: TrkA_C; pfam02080
398580004733	TrkA-N domain; Region: TrkA_N; pfam02254
398580004734	TrkA-C domain; Region: TrkA_C; pfam02080
398580004735	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399
398580004736	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
398580004737	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
398580004738	active site
398580004739	phosphorylation site [posttranslational modification]
398580004740	intermolecular recognition site; other site
398580004741	dimerization interface [polypeptide binding]; other site
398580004742	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
398580004743	Walker A motif; other site
398580004744	ATP binding site [chemical binding]; other site
398580004745	Walker B motif; other site
398580004746	arginine finger; other site
398580004747	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
398580004748	Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000
398580004749	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
398580004750	dimerization interface [polypeptide binding]; other site
398580004751	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
398580004752	putative active site [active]
398580004753	heme pocket [chemical binding]; other site
398580004754	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
398580004755	dimer interface [polypeptide binding]; other site
398580004756	phosphorylation site [posttranslational modification]
398580004757	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
398580004758	ATP binding site [chemical binding]; other site
398580004759	Mg2+ binding site [ion binding]; other site
398580004760	G-X-G motif; other site
398580004761	nitrogen regulation protein NR(I); Region: ntrC; TIGR01818
398580004762	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
398580004763	active site
398580004764	phosphorylation site [posttranslational modification]
398580004765	intermolecular recognition site; other site
398580004766	dimerization interface [polypeptide binding]; other site
398580004767	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
398580004768	Walker A motif; other site
398580004769	ATP binding site [chemical binding]; other site
398580004770	Walker B motif; other site
398580004771	arginine finger; other site
398580004772	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
398580004773	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
398580004774	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
398580004775	dimer interface [polypeptide binding]; other site
398580004776	phosphorylation site [posttranslational modification]
398580004777	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
398580004778	ATP binding site [chemical binding]; other site
398580004779	Mg2+ binding site [ion binding]; other site
398580004780	G-X-G motif; other site
398580004781	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
398580004782	Dihydrouridine synthase (Dus); Region: Dus; pfam01207
398580004783	FMN binding site [chemical binding]; other site
398580004784	active site
398580004785	catalytic residues [active]
398580004786	substrate binding site [chemical binding]; other site
398580004787	bifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase protein; Provisional; Region: ispDF; PRK09382
398580004788	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
398580004789	substrate binding site; other site
398580004790	dimer interface; other site
398580004791	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
398580004792	homotrimer interaction site [polypeptide binding]; other site
398580004793	zinc binding site [ion binding]; other site
398580004794	CDP-binding sites; other site
398580004795	Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971
398580004796	tetramer interfaces [polypeptide binding]; other site
398580004797	binuclear metal-binding site [ion binding]; other site
398580004798	Competence-damaged protein; Region: CinA; pfam02464
398580004799	Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813
398580004800	putative coenzyme Q binding site [chemical binding]; other site
398580004801	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
398580004802	active site
398580004803	lipoyl synthase; Provisional; Region: PRK05481
398580004804	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
398580004805	FeS/SAM binding site; other site
398580004806	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cl07055
398580004807	DnaA box-binding interface [nucleotide binding]; other site
398580004808	Trimethylamine methyltransferase (MTTB); Region: MTTB; pfam06253
398580004809	GMP synthase; Reviewed; Region: guaA; PRK00074
398580004810	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
398580004811	AMP/PPi binding site [chemical binding]; other site
398580004812	candidate oxyanion hole; other site
398580004813	catalytic triad [active]
398580004814	potential glutamine specificity residues [chemical binding]; other site
398580004815	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
398580004816	ATP Binding subdomain [chemical binding]; other site
398580004817	Ligand Binding sites [chemical binding]; other site
398580004818	Dimerization subdomain; other site
398580004819	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
398580004820	putative active site [active]
398580004821	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
398580004822	EamA-like transporter family; Region: EamA; pfam00892
398580004823	Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479
398580004824	Homoserine O-succinyltransferase; Region: HTS; pfam04204
398580004825	Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131
398580004826	proposed active site lysine [active]
398580004827	conserved cys residue [active]
398580004828	Alpha/beta hydrolase of unknown function (DUF1057); Region: DUF1057; pfam06342
398580004829	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
398580004830	polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707
398580004831	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
398580004832	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
398580004833	WHG domain; Region: WHG; pfam13305
398580004834	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
398580004835	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
398580004836	Walker A/P-loop; other site
398580004837	ATP binding site [chemical binding]; other site
398580004838	Q-loop/lid; other site
398580004839	ABC transporter signature motif; other site
398580004840	Walker B; other site
398580004841	D-loop; other site
398580004842	H-loop/switch region; other site
398580004843	TOBE domain; Region: TOBE_2; pfam08402
398580004844	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
398580004845	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
398580004846	dimer interface [polypeptide binding]; other site
398580004847	conserved gate region; other site
398580004848	putative PBP binding loops; other site
398580004849	ABC-ATPase subunit interface; other site
398580004850	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
398580004851	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
398580004852	dimer interface [polypeptide binding]; other site
398580004853	conserved gate region; other site
398580004854	putative PBP binding loops; other site
398580004855	ABC-ATPase subunit interface; other site
398580004856	Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
398580004857	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
398580004858	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
398580004859	23S rRNA interface [nucleotide binding]; other site
398580004860	L3 interface [polypeptide binding]; other site
398580004861	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
398580004862	CoenzymeA binding site [chemical binding]; other site
398580004863	subunit interaction site [polypeptide binding]; other site
398580004864	PHB binding site; other site
398580004865	enoyl-CoA hydratase; Validated; Region: PRK08139
398580004866	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
398580004867	substrate binding site [chemical binding]; other site
398580004868	oxyanion hole (OAH) forming residues; other site
398580004869	trimer interface [polypeptide binding]; other site
398580004870	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
398580004871	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
398580004872	N-acetyl-D-glucosamine binding site [chemical binding]; other site
398580004873	catalytic residue [active]
398580004874	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
398580004875	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
398580004876	dimer interface [polypeptide binding]; other site
398580004877	ssDNA binding site [nucleotide binding]; other site
398580004878	tetramer (dimer of dimers) interface [polypeptide binding]; other site
398580004879	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
398580004880	Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465
398580004881	active site
398580004882	dimer interface [polypeptide binding]; other site
398580004883	metal binding site [ion binding]; metal-binding site
398580004884	shikimate kinase; Provisional; Region: PRK13946
398580004885	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
398580004886	magnesium binding site [ion binding]; other site
398580004887	putative shikimate binding site; other site
398580004888	site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283
398580004889	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
398580004890	active site
398580004891	DNA binding site [nucleotide binding]
398580004892	Int/Topo IB signature motif; other site
398580004893	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
398580004894	Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536
398580004895	Domain of unknown function DUF21; Region: DUF21; pfam01595
398580004896	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
398580004897	Transporter associated domain; Region: CorC_HlyC; smart01091
398580004898	Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872
398580004899	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
398580004900	Walker A motif; other site
398580004901	ATP binding site [chemical binding]; other site
398580004902	Invasion associated locus B (IalB) protein; Region: IalB; pfam06776
398580004903	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
398580004904	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
398580004905	dimer interface [polypeptide binding]; other site
398580004906	active site
398580004907	acyl carrier protein; Provisional; Region: acpP; PRK00982
398580004908	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
398580004909	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
398580004910	trimer interface [polypeptide binding]; other site
398580004911	active site
398580004912	UDP-GlcNAc binding site [chemical binding]; other site
398580004913	lipid binding site [chemical binding]; lipid-binding site
398580004914	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989
398580004915	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
398580004916	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
398580004917	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
398580004918	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108
398580004919	Peptidase M15; Region: Peptidase_M15_3; cl01194
398580004920	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
398580004921	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
398580004922	putative substrate binding site [chemical binding]; other site
398580004923	putative ATP binding site [chemical binding]; other site
398580004924	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
398580004925	active site
398580004926	catalytic triad [active]
398580004927	oxyanion hole [active]
398580004928	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
398580004929	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
398580004930	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
398580004931	catalytic residue [active]
398580004932	Yip1 domain; Region: Yip1; cl17815
398580004933	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
398580004934	Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458
398580004935	Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396
398580004936	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
398580004937	Walker A/P-loop; other site
398580004938	ATP binding site [chemical binding]; other site
398580004939	Q-loop/lid; other site
398580004940	ABC transporter signature motif; other site
398580004941	Walker B; other site
398580004942	D-loop; other site
398580004943	H-loop/switch region; other site
398580004944	Putative heavy-metal-binding; Region: YbjQ_1; cl00426
398580004945	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814
398580004946	putative ABC transporter; Region: ycf24; CHL00085
398580004947	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
398580004948	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
398580004949	Transcriptional regulator; Region: Rrf2; cl17282
398580004950	Rrf2 family protein; Region: rrf2_super; TIGR00738
398580004951	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945
398580004952	VIT family; Region: VIT1; pfam01988
398580004953	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
398580004954	Uncharacterized conserved protein [Function unknown]; Region: COG1284
398580004955	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
398580004956	Protein of unknown function (DUF1330); Region: DUF1330; cl02288
398580004957	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
398580004958	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
398580004959	motif 1; other site
398580004960	active site
398580004961	motif 2; other site
398580004962	motif 3; other site
398580004963	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
398580004964	recombinase A; Provisional; Region: recA; PRK09354
398580004965	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
398580004966	hexamer interface [polypeptide binding]; other site
398580004967	Walker A motif; other site
398580004968	ATP binding site [chemical binding]; other site
398580004969	Walker B motif; other site
398580004970	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
398580004971	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
398580004972	dimer interface [polypeptide binding]; other site
398580004973	phosphorylation site [posttranslational modification]
398580004974	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
398580004975	ATP binding site [chemical binding]; other site
398580004976	Mg2+ binding site [ion binding]; other site
398580004977	G-X-G motif; other site
398580004978	Response regulator receiver domain; Region: Response_reg; pfam00072
398580004979	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
398580004980	active site
398580004981	phosphorylation site [posttranslational modification]
398580004982	intermolecular recognition site; other site
398580004983	dimerization interface [polypeptide binding]; other site
398580004984	16S rRNA methyltransferase B; Provisional; Region: PRK10901
398580004985	NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446
398580004986	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
398580004987	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
398580004988	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
398580004989	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
398580004990	active site
398580004991	2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836
398580004992	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
398580004993	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
398580004994	Walker A/P-loop; other site
398580004995	ATP binding site [chemical binding]; other site
398580004996	Q-loop/lid; other site
398580004997	ABC transporter signature motif; other site
398580004998	Walker B; other site
398580004999	D-loop; other site
398580005000	H-loop/switch region; other site
398580005001	TOBE domain; Region: TOBE_2; pfam08402
398580005002	Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase) and related proteins; Region: AmyAc_OligoGlu; cd11330
398580005003	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
398580005004	active site
398580005005	catalytic site [active]
398580005006	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
398580005007	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
398580005008	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
398580005009	dimer interface [polypeptide binding]; other site
398580005010	conserved gate region; other site
398580005011	putative PBP binding loops; other site
398580005012	ABC-ATPase subunit interface; other site
398580005013	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
398580005014	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
398580005015	dimer interface [polypeptide binding]; other site
398580005016	putative PBP binding loops; other site
398580005017	ABC-ATPase subunit interface; other site
398580005018	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
398580005019	Transcriptional regulators [Transcription]; Region: PurR; COG1609
398580005020	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
398580005021	DNA binding site [nucleotide binding]
398580005022	domain linker motif; other site
398580005023	Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271
398580005024	ligand binding site [chemical binding]; other site
398580005025	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046
398580005026	beta-galactosidase; Region: BGL; TIGR03356
398580005027	glucokinase, proteobacterial type; Region: glk; TIGR00749
398580005028	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
398580005029	nucleotide binding site [chemical binding]; other site
398580005030	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
398580005031	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
398580005032	ABC-ATPase subunit  interface; other site
398580005033	dimer interface [polypeptide binding]; other site
398580005034	putative PBP binding regions; other site
398580005035	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
398580005036	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
398580005037	ABC-ATPase subunit  interface; other site
398580005038	dimer interface [polypeptide binding]; other site
398580005039	putative PBP binding regions; other site
398580005040	manganese/iron transporter ATP-binding protein; Provisional; Region: PRK15056
398580005041	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
398580005042	Metal binding protein PsaA.  These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137
398580005043	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
398580005044	metal binding site [ion binding]; metal-binding site
398580005045	Transcriptional regulator; Region: Rrf2; cl17282
398580005046	Rrf2 family protein; Region: rrf2_super; TIGR00738
398580005047	Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707
398580005048	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
398580005049	active site
398580005050	phosphorylation site [posttranslational modification]
398580005051	intermolecular recognition site; other site
398580005052	dimerization interface [polypeptide binding]; other site
398580005053	ANTAR domain; Region: ANTAR; pfam03861
398580005054	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
398580005055	NMT1-like family; Region: NMT1_2; pfam13379
398580005056	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
398580005057	NMT1-like family; Region: NMT1_2; pfam13379
398580005058	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
398580005059	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
398580005060	dimer interface [polypeptide binding]; other site
398580005061	conserved gate region; other site
398580005062	putative PBP binding loops; other site
398580005063	ABC-ATPase subunit interface; other site
398580005064	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
398580005065	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
398580005066	Walker A/P-loop; other site
398580005067	ATP binding site [chemical binding]; other site
398580005068	Q-loop/lid; other site
398580005069	ABC transporter signature motif; other site
398580005070	Walker B; other site
398580005071	D-loop; other site
398580005072	H-loop/switch region; other site
398580005073	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
398580005074	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
398580005075	Walker A/P-loop; other site
398580005076	ATP binding site [chemical binding]; other site
398580005077	Q-loop/lid; other site
398580005078	ABC transporter signature motif; other site
398580005079	Walker B; other site
398580005080	D-loop; other site
398580005081	H-loop/switch region; other site
398580005082	Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
398580005083	heme-binding site [chemical binding]; other site
398580005084	NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251
398580005085	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
398580005086	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
398580005087	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
398580005088	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
398580005089	Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530
398580005090	[2Fe-2S] cluster binding site [ion binding]; other site
398580005091	formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591
398580005092	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
398580005093	[4Fe-4S] binding site [ion binding]; other site
398580005094	molybdopterin cofactor binding site; other site
398580005095	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791
398580005096	molybdopterin cofactor binding site; other site
398580005097	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
398580005098	hypothetical protein; Validated; Region: PRK09071
398580005099	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
398580005100	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
398580005101	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
398580005102	active site
398580005103	SAM binding site [chemical binding]; other site
398580005104	homodimer interface [polypeptide binding]; other site
398580005105	23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293
398580005106	FtsJ-like methyltransferase; Region: FtsJ; pfam01728
398580005107	exopolyphosphatase; Region: exo_poly_only; TIGR03706
398580005108	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
398580005109	Virulence factor; Region: Virulence_fact; pfam13769
398580005110	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cl00246
398580005111	FAD binding site [chemical binding]; other site
398580005112	haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509
398580005113	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
398580005114	motif II; other site
398580005115	Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410
398580005116	methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase; Validated; Region: PRK07535
398580005117	substrate binding pocket [chemical binding]; other site
398580005118	dimer interface [polypeptide binding]; other site
398580005119	inhibitor binding site; inhibition site
398580005120	Uncharacterized metal-binding protein [General function prediction only]; Region: COG3894
398580005121	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
398580005122	active site
398580005123	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
398580005124	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
398580005125	active site
398580005126	dimer interface [polypeptide binding]; other site
398580005127	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
398580005128	dimer interface [polypeptide binding]; other site
398580005129	active site
398580005130	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
398580005131	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
398580005132	putative active site [active]
398580005133	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
398580005134	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
398580005135	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
398580005136	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
398580005137	Radical SAM superfamily; Region: Radical_SAM; pfam04055
398580005138	FeS/SAM binding site; other site
398580005139	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
398580005140	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
398580005141	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
398580005142	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
398580005143	active site
398580005144	Predicted esterase [General function prediction only]; Region: COG0400
398580005145	putative hydrolase; Provisional; Region: PRK11460
398580005146	3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122
398580005147	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
398580005148	minor groove reading motif; other site
398580005149	helix-hairpin-helix signature motif; other site
398580005150	active site
398580005151	Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099
398580005152	Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571
398580005153	cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075
398580005154	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
398580005155	active site
398580005156	SAM binding site [chemical binding]; other site
398580005157	homodimer interface [polypeptide binding]; other site
398580005158	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
398580005159	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
398580005160	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
398580005161	conserved cys residue [active]
398580005162	Major Facilitator Superfamily; Region: MFS_1; pfam07690
398580005163	Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210
398580005164	putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344
398580005165	Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941
398580005166	active site
398580005167	catalytic residues [active]
398580005168	metal binding site [ion binding]; metal-binding site
398580005169	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
398580005170	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
398580005171	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
398580005172	active site
398580005173	HIGH motif; other site
398580005174	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
398580005175	KMSKS motif; other site
398580005176	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
398580005177	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254
398580005178	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217
398580005179	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
398580005180	NAD(P) binding site [chemical binding]; other site
398580005181	active site
398580005182	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
398580005183	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
398580005184	dimer interface [polypeptide binding]; other site
398580005185	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
398580005186	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
398580005187	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cl17326
398580005188	putative DNA binding helix; other site
398580005189	metal binding site 2 [ion binding]; metal-binding site
398580005190	metal binding site 1 [ion binding]; metal-binding site
398580005191	dimer interface [polypeptide binding]; other site
398580005192	structural Zn2+ binding site [ion binding]; other site
398580005193	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
398580005194	intersubunit interface [polypeptide binding]; other site
398580005195	Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019
398580005196	metal binding site [ion binding]; metal-binding site
398580005197	methionine sulfoxide reductase B; Provisional; Region: PRK00222
398580005198	SelR domain; Region: SelR; pfam01641
398580005199	Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496
398580005200	Nuclease-related domain; Region: NERD; pfam08378
398580005201	Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551
398580005202	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
398580005203	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
398580005204	Mechanosensitive ion channel; Region: MS_channel; pfam00924
398580005205	Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028
398580005206	putative GSH binding site [chemical binding]; other site
398580005207	catalytic residues [active]
398580005208	BolA-like protein; Region: BolA; pfam01722
398580005209	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
398580005210	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
398580005211	dimerization interface [polypeptide binding]; other site
398580005212	ATP binding site [chemical binding]; other site
398580005213	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
398580005214	dimerization interface [polypeptide binding]; other site
398580005215	ATP binding site [chemical binding]; other site
398580005216	ABC transporter ATPase component; Reviewed; Region: PRK11147
398580005217	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
398580005218	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
398580005219	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
398580005220	SmpA / OmlA family; Region: SmpA_OmlA; pfam04355
398580005221	Uncharacterized ACR, COG1399; Region: DUF177; pfam02620
398580005222	50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286
398580005223	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
398580005224	putative phosphate acyltransferase; Provisional; Region: PRK05331
398580005225	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
398580005226	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
398580005227	dimer interface [polypeptide binding]; other site
398580005228	active site
398580005229	CoA binding pocket [chemical binding]; other site
398580005230	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
398580005231	IHF dimer interface [polypeptide binding]; other site
398580005232	IHF - DNA interface [nucleotide binding]; other site
398580005233	Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765
398580005234	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
398580005235	DNA binding residues [nucleotide binding]
398580005236	2'-deoxycytidine 5'-triphosphate deaminase; Provisional; Region: PRK07559
398580005237	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cl00493
398580005238	trimer interface [polypeptide binding]; other site
398580005239	active site
398580005240	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
398580005241	trimer interface [polypeptide binding]; other site
398580005242	active site
398580005243	Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079
398580005244	Rec8/ScpA/Scc1-like protein (kleisin family) [Replication,    recombination, and repair]; Region: scpA; COG1354
398580005245	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
398580005246	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
398580005247	Sporulation related domain; Region: SPOR; pfam05036
398580005248	arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611
398580005249	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
398580005250	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
398580005251	active site
398580005252	HIGH motif; other site
398580005253	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
398580005254	KMSK motif region; other site
398580005255	tRNA binding surface [nucleotide binding]; other site
398580005256	DALR anticodon binding domain; Region: DALR_1; smart00836
398580005257	anticodon binding site; other site
398580005258	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286
398580005259	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
398580005260	Zn2+ binding site [ion binding]; other site
398580005261	Mg2+ binding site [ion binding]; other site
398580005262	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
398580005263	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
398580005264	Domain of unknown function (DUF4167); Region: DUF4167; pfam13763
398580005265	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
398580005266	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
398580005267	peptide chain release factor 1; Validated; Region: prfA; PRK00591
398580005268	This domain is found in peptide chain release factors; Region: PCRF; smart00937
398580005269	RF-1 domain; Region: RF-1; pfam00472
398580005270	Protein of unknown function (DUF1499); Region: DUF1499; pfam07386
398580005271	Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592
398580005272	agmatinase; Region: agmatinase; TIGR01230
398580005273	oligomer interface [polypeptide binding]; other site
398580005274	putative active site [active]
398580005275	Mn binding site [ion binding]; other site
398580005276	Cell division protein ZapA; Region: ZapA; pfam05164
398580005277	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
398580005278	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
398580005279	TPP-binding site [chemical binding]; other site
398580005280	dimer interface [polypeptide binding]; other site
398580005281	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
398580005282	PYR/PP interface [polypeptide binding]; other site
398580005283	dimer interface [polypeptide binding]; other site
398580005284	TPP binding site [chemical binding]; other site
398580005285	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
398580005286	Protein of unknown function (DUF808); Region: DUF808; cl01002
398580005287	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
398580005288	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
398580005289	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
398580005290	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
398580005291	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
398580005292	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
398580005293	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
398580005294	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
398580005295	Coenzyme A binding pocket [chemical binding]; other site
398580005296	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
398580005297	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
398580005298	active site
398580005299	(T/H)XGH motif; other site
398580005300	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623
398580005301	FOG: CBS domain [General function prediction only]; Region: COG0517
398580005302	Transcriptional regulator [Transcription]; Region: LysR; COG0583
398580005303	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
398580005304	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
398580005305	dimerization interface [polypeptide binding]; other site
398580005306	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
398580005307	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
398580005308	tetrameric interface [polypeptide binding]; other site
398580005309	NAD binding site [chemical binding]; other site
398580005310	catalytic residues [active]
398580005311	carboxylate-amine ligase; Provisional; Region: PRK13515
398580005312	carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050
398580005313	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
398580005314	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
398580005315	active site
398580005316	3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617
398580005317	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
398580005318	substrate binding site [chemical binding]; other site
398580005319	oxyanion hole (OAH) forming residues; other site
398580005320	trimer interface [polypeptide binding]; other site
398580005321	2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766
398580005322	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
398580005323	3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692
398580005324	enoyl-CoA hydratase; Provisional; Region: PRK08140
398580005325	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
398580005326	substrate binding site [chemical binding]; other site
398580005327	oxyanion hole (OAH) forming residues; other site
398580005328	trimer interface [polypeptide binding]; other site
398580005329	Haemolysin XhlA; Region: XhlA; pfam10779
398580005330	Protein of unknown function (DUF3154); Region: DUF3154; pfam11351
398580005331	Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838
398580005332	Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374
398580005333	cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13254
398580005334	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
398580005335	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
398580005336	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
398580005337	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ACT14924; Region: LPLAT_ACT14924-like; cd07986
398580005338	putative acyl-acceptor binding pocket; other site
398580005339	indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193
398580005340	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
398580005341	dimer interface [polypeptide binding]; other site
398580005342	PYR/PP interface [polypeptide binding]; other site
398580005343	TPP binding site [chemical binding]; other site
398580005344	substrate binding site [chemical binding]; other site
398580005345	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
398580005346	TPP-binding site [chemical binding]; other site
398580005347	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
398580005348	Transcriptional regulator [Transcription]; Region: LysR; COG0583
398580005349	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
398580005350	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
398580005351	putative effector binding pocket; other site
398580005352	dimerization interface [polypeptide binding]; other site
398580005353	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
398580005354	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
398580005355	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
398580005356	ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265
398580005357	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
398580005358	Walker A/P-loop; other site
398580005359	ATP binding site [chemical binding]; other site
398580005360	Q-loop/lid; other site
398580005361	ABC transporter signature motif; other site
398580005362	Walker B; other site
398580005363	D-loop; other site
398580005364	H-loop/switch region; other site
398580005365	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
398580005366	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
398580005367	keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718
398580005368	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
398580005369	active site
398580005370	intersubunit interface [polypeptide binding]; other site
398580005371	catalytic residue [active]
398580005372	phosphogluconate dehydratase; Validated; Region: PRK09054
398580005373	6-phosphogluconate dehydratase; Region: edd; TIGR01196
398580005374	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
398580005375	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
398580005376	putative RNA binding site [nucleotide binding]; other site
398580005377	PIN domain; Region: PIN_3; pfam13470
398580005378	Peptidase family M48; Region: Peptidase_M48; cl12018
398580005379	bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14108
398580005380	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
398580005381	metal binding triad; other site
398580005382	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
398580005383	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
398580005384	metal binding triad; other site
398580005385	Bacterial OB fold (BOF) protein; Region: BOF; cl01196
398580005386	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
398580005387	Found in ATP-dependent protease La (LON); Region: LON; smart00464
398580005388	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
398580005389	Walker A motif; other site
398580005390	ATP binding site [chemical binding]; other site
398580005391	Walker B motif; other site
398580005392	arginine finger; other site
398580005393	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083
398580005394	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
398580005395	acetolactate synthase 3 catalytic subunit; Validated; Region: PRK09107
398580005396	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
398580005397	PYR/PP interface [polypeptide binding]; other site
398580005398	dimer interface [polypeptide binding]; other site
398580005399	TPP binding site [chemical binding]; other site
398580005400	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
398580005401	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
398580005402	TPP-binding site [chemical binding]; other site
398580005403	dimer interface [polypeptide binding]; other site
398580005404	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
398580005405	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
398580005406	putative valine binding site [chemical binding]; other site
398580005407	dimer interface [polypeptide binding]; other site
398580005408	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
398580005409	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
398580005410	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
398580005411	[2Fe-2S] cluster binding site [ion binding]; other site
398580005412	C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680
398580005413	alpha subunit interface [polypeptide binding]; other site
398580005414	active site
398580005415	substrate binding site [chemical binding]; other site
398580005416	Fe binding site [ion binding]; other site
398580005417	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
398580005418	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
398580005419	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
398580005420	DNA binding residues [nucleotide binding]
398580005421	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07562
398580005422	Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471
398580005423	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
398580005424	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
398580005425	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
398580005426	TSCPD domain; Region: TSCPD; pfam12637
398580005427	Uncharacterized ACR, COG1430; Region: DUF192; pfam02643
398580005428	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
398580005429	DNA-binding site [nucleotide binding]; DNA binding site
398580005430	RNA-binding motif; other site
398580005431	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
398580005432	DNA-binding site [nucleotide binding]; DNA binding site
398580005433	RNA-binding motif; other site
398580005434	pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558
398580005435	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
398580005436	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
398580005437	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08159
398580005438	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
398580005439	NAD binding site [chemical binding]; other site
398580005440	homotetramer interface [polypeptide binding]; other site
398580005441	homodimer interface [polypeptide binding]; other site
398580005442	substrate binding site [chemical binding]; other site
398580005443	active site
398580005444	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
398580005445	LysE type translocator; Region: LysE; cl00565
398580005446	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
398580005447	active site
398580005448	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
398580005449	Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155
398580005450	pyridoxal 5'-phosphate binding site [chemical binding]; other site
398580005451	homodimer interface [polypeptide binding]; other site
398580005452	catalytic residue [active]
398580005453	SurA N-terminal domain; Region: SurA_N_3; cl07813
398580005454	PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145
398580005455	anthranilate synthase component I; Provisional; Region: PRK13573
398580005456	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
398580005457	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
398580005458	Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936
398580005459	NodB motif; other site
398580005460	putative active site [active]
398580005461	putative catalytic site [active]
398580005462	Zn binding site [ion binding]; other site
398580005463	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
398580005464	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
398580005465	glutamine binding [chemical binding]; other site
398580005466	catalytic triad [active]
398580005467	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
398580005468	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
398580005469	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
398580005470	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
398580005471	active site
398580005472	ribulose/triose binding site [chemical binding]; other site
398580005473	phosphate binding site [ion binding]; other site
398580005474	substrate (anthranilate) binding pocket [chemical binding]; other site
398580005475	product (indole) binding pocket [chemical binding]; other site
398580005476	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
398580005477	trimer interface [polypeptide binding]; other site
398580005478	dimer interface [polypeptide binding]; other site
398580005479	putative active site [active]
398580005480	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
398580005481	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
398580005482	dimer interface [polypeptide binding]; other site
398580005483	putative functional site; other site
398580005484	putative MPT binding site; other site
398580005485	LexA repressor; Validated; Region: PRK00215
398580005486	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
398580005487	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
398580005488	Catalytic site [active]
398580005489	Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658
398580005490	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
398580005491	Competence protein; Region: Competence; pfam03772
398580005492	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
398580005493	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
398580005494	active site
398580005495	HIGH motif; other site
398580005496	nucleotide binding site [chemical binding]; other site
398580005497	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
398580005498	active site
398580005499	KMSKS motif; other site
398580005500	Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114
398580005501	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
398580005502	dimer interface [polypeptide binding]; other site
398580005503	active site
398580005504	citrylCoA binding site [chemical binding]; other site
398580005505	NADH binding [chemical binding]; other site
398580005506	cationic pore residues; other site
398580005507	oxalacetate/citrate binding site [chemical binding]; other site
398580005508	coenzyme A binding site [chemical binding]; other site
398580005509	catalytic triad [active]
398580005510	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
398580005511	Ligand Binding Site [chemical binding]; other site
398580005512	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
398580005513	Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548
398580005514	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
398580005515	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
398580005516	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
398580005517	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
398580005518	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
398580005519	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416
398580005520	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
398580005521	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
398580005522	Bacterial protein of unknown function (DUF924); Region: DUF924; pfam06041
398580005523	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
398580005524	putative substrate translocation pore; other site
398580005525	Major Facilitator Superfamily; Region: MFS_1; pfam07690
398580005526	Autoinducer binding domain; Region: Autoind_bind; pfam03472
398580005527	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
398580005528	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
398580005529	DNA binding residues [nucleotide binding]
398580005530	dimerization interface [polypeptide binding]; other site
398580005531	Mechanosensitive ion channel; Region: MS_channel; pfam00924
398580005532	Pirin-related protein [General function prediction only]; Region: COG1741
398580005533	Pirin; Region: Pirin; pfam02678
398580005534	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
398580005535	LuxR family transcriptional regulatory, chaperone HchA-associated; Region: reg_near_HchA; TIGR03541
398580005536	Autoinducer binding domain; Region: Autoind_bind; pfam03472
398580005537	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
398580005538	DNA binding residues [nucleotide binding]
398580005539	dimerization interface [polypeptide binding]; other site
398580005540	mannosyl-3-phosphoglycerate phosphatase; Reviewed; Region: PRK00192
398580005541	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
398580005542	active site
398580005543	motif I; other site
398580005544	motif II; other site
398580005545	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
398580005546	putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915
398580005547	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
398580005548	Sodium Bile acid symporter family; Region: SBF; cl17470
398580005549	Alpha amylase catalytic domain found in sucrose phosphorylase-like proteins (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase-like_1; cd11356
398580005550	sucrose phosphorylase; Region: sucrose_gtfA; TIGR03852
398580005551	active site
398580005552	homodimer interface [polypeptide binding]; other site
398580005553	catalytic site [active]
398580005554	Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212
398580005555	Protein of unknown function (DUF861); Region: Cupin_3; cl17594
398580005556	Predicted membrane protein [Function unknown]; Region: COG2855
398580005557	sulfoacetaldehyde acetyltransferase; Validated; Region: PRK07525
398580005558	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
398580005559	PYR/PP interface [polypeptide binding]; other site
398580005560	dimer interface [polypeptide binding]; other site
398580005561	TPP binding site [chemical binding]; other site
398580005562	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
398580005563	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
398580005564	TPP-binding site [chemical binding]; other site
398580005565	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
398580005566	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
398580005567	SnoaL-like domain; Region: SnoaL_2; pfam12680
398580005568	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
398580005569	Ligand Binding Site [chemical binding]; other site
398580005570	DctM-like transporters; Region: DctM; pfam06808
398580005571	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
398580005572	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
398580005573	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
398580005574	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
398580005575	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
398580005576	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
398580005577	DNA-binding site [nucleotide binding]; DNA binding site
398580005578	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
398580005579	pyridoxal 5'-phosphate binding site [chemical binding]; other site
398580005580	homodimer interface [polypeptide binding]; other site
398580005581	catalytic residue [active]
398580005582	Hint domain; Region: Hint_2; pfam13403
398580005583	Uncharacterized conserved protein [Function unknown]; Region: COG0062
398580005584	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
398580005585	putative substrate binding site [chemical binding]; other site
398580005586	putative ATP binding site [chemical binding]; other site
398580005587	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
398580005588	Nitrogen regulatory protein P-II; Region: P-II; smart00938
398580005589	glutamine synthetase; Provisional; Region: glnA; PRK09469
398580005590	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
398580005591	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
398580005592	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
398580005593	OsmC-like protein; Region: OsmC; pfam02566
398580005594	adenylosuccinate lyase; Provisional; Region: PRK07492
398580005595	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
398580005596	tetramer interface [polypeptide binding]; other site
398580005597	active site
398580005598	flagellar motor switch protein G; Validated; Region: fliG; PRK05686
398580005599	FliG C-terminal domain; Region: FliG_C; pfam01706
398580005600	nitrile hydratase, beta subunit; Region: nitrile_beta; TIGR03888
398580005601	nitrile hydratase, beta subunit; Region: nitrile_beta; TIGR03888
398580005602	Nitrile hydratase, alpha chain; Region: NHase_alpha; pfam02979
398580005603	Ribosomally synthesized peptide prototyped by Frankia Franean1_4349; Region: Frankia_peptide; pfam14407
398580005604	NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793
398580005605	Protein of unknown function (DUF1223); Region: DUF1223; pfam06764
398580005606	aconitate hydratase; Validated; Region: PRK09277
398580005607	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
398580005608	substrate binding site [chemical binding]; other site
398580005609	Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285
398580005610	ligand binding site [chemical binding]; other site
398580005611	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
398580005612	substrate binding site [chemical binding]; other site
398580005613	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
398580005614	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
398580005615	heme exporter protein CcmC; Region: ccmC; TIGR01191
398580005616	heme exporter protein CcmB; Region: ccmB; TIGR01190
398580005617	cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13539
398580005618	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
398580005619	Walker A/P-loop; other site
398580005620	ATP binding site [chemical binding]; other site
398580005621	Q-loop/lid; other site
398580005622	ABC transporter signature motif; other site
398580005623	Walker B; other site
398580005624	D-loop; other site
398580005625	H-loop/switch region; other site
398580005626	Mth938-like domain. The members of this family include: Mth938, 2P1, Xcr35, Rpa2829, and several uncharacterized sequences. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a...; Region: Mth938-like; cd00248
398580005627	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
398580005628	Protein export membrane protein; Region: SecD_SecF; pfam02355
398580005629	SecD export protein N-terminal TM region; Region: SecD-TM1; cl08136
398580005630	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
398580005631	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
398580005632	Preprotein translocase subunit; Region: YajC; pfam02699
398580005633	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
398580005634	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
398580005635	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
398580005636	seryl-tRNA synthetase; Provisional; Region: PRK05431
398580005637	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
398580005638	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
398580005639	dimer interface [polypeptide binding]; other site
398580005640	active site
398580005641	motif 1; other site
398580005642	motif 2; other site
398580005643	motif 3; other site
398580005644	Transglycosylase SLT domain; Region: SLT_2; pfam13406
398580005645	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
398580005646	N-acetyl-D-glucosamine binding site [chemical binding]; other site
398580005647	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
398580005648	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
398580005649	Predicted integral membrane protein (DUF2189); Region: DUF2189; cl02291
398580005650	glutamine synthetase, type III; Region: gln_synth_III; TIGR03105
398580005651	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
398580005652	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
398580005653	Conserved region in glutamate synthase; Region: Glu_synthase; pfam01645
398580005654	active site
398580005655	FMN binding site [chemical binding]; other site
398580005656	substrate binding site [chemical binding]; other site
398580005657	3Fe-4S cluster binding site [ion binding]; other site
398580005658	GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS),  in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cd00504
398580005659	domain_subunit interface; other site
398580005660	Glutamate synthase domain 1 [Amino acid transport and metabolism]; Region: GltB; COG0067
398580005661	Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319
398580005662	Glutamine amidotransferases class-II (Gn-AT)_GlxB-type.  GlxB is a glutamine amidotransferase-like protein of unknown function found in bacteria and archaea. GlxB has a structural fold similar to that of other class II glutamine amidotransferases...; Region: GlxB; cd01907
398580005663	putative active site [active]
398580005664	DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943
398580005665	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
398580005666	non-specific DNA binding site [nucleotide binding]; other site
398580005667	salt bridge; other site
398580005668	sequence-specific DNA binding site [nucleotide binding]; other site
398580005669	Cupin domain; Region: Cupin_2; pfam07883
398580005670	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
398580005671	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
398580005672	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
398580005673	Cytochrome c; Region: Cytochrom_C; cl11414
398580005674	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
398580005675	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
398580005676	Protein of unknown function, DUF417; Region: DUF417; cl01162
398580005677	Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418
398580005678	GSH binding site [chemical binding]; other site
398580005679	catalytic residues [active]
398580005680	Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011
398580005681	Predicted membrane protein [Function unknown]; Region: COG4325
398580005682	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3825
398580005683	Protein of unknown function (DUF2927); Region: DUF2927; pfam11150
398580005684	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
398580005685	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
398580005686	Coenzyme A binding pocket [chemical binding]; other site
398580005687	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
398580005688	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
398580005689	Walker A motif; other site
398580005690	ATP binding site [chemical binding]; other site
398580005691	Walker B motif; other site
398580005692	arginine finger; other site
398580005693	RNA polymerase-binding protein DksA; Region: dksA; TIGR02420
398580005694	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
398580005695	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654
398580005696	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
398580005697	putative catalytic site [active]
398580005698	putative phosphate binding site [ion binding]; other site
398580005699	active site
398580005700	metal binding site A [ion binding]; metal-binding site
398580005701	DNA binding site [nucleotide binding]
398580005702	putative AP binding site [nucleotide binding]; other site
398580005703	putative metal binding site B [ion binding]; other site
398580005704	Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349
398580005705	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
398580005706	catalytic site [active]
398580005707	putative active site [active]
398580005708	putative substrate binding site [chemical binding]; other site
398580005709	HRDC domain; Region: HRDC; pfam00570
398580005710	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
398580005711	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
398580005712	active site
398580005713	substrate binding site [chemical binding]; other site
398580005714	cosubstrate binding site; other site
398580005715	catalytic site [active]
398580005716	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
398580005717	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
398580005718	dimerization interface [polypeptide binding]; other site
398580005719	putative ATP binding site [chemical binding]; other site
398580005720	Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
398580005721	heme-binding site [chemical binding]; other site
398580005722	Uncharacterized conserved protein [Function unknown]; Region: COG3287
398580005723	FIST N domain; Region: FIST; pfam08495
398580005724	FIST C domain; Region: FIST_C; pfam10442
398580005725	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
398580005726	PAS domain; Region: PAS_9; pfam13426
398580005727	putative active site [active]
398580005728	heme pocket [chemical binding]; other site
398580005729	PAS fold; Region: PAS_7; pfam12860
398580005730	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
398580005731	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
398580005732	putative active site [active]
398580005733	heme pocket [chemical binding]; other site
398580005734	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
398580005735	dimer interface [polypeptide binding]; other site
398580005736	phosphorylation site [posttranslational modification]
398580005737	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
398580005738	ATP binding site [chemical binding]; other site
398580005739	Mg2+ binding site [ion binding]; other site
398580005740	G-X-G motif; other site
398580005741	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
398580005742	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
398580005743	active site
398580005744	phosphorylation site [posttranslational modification]
398580005745	intermolecular recognition site; other site
398580005746	dimerization interface [polypeptide binding]; other site
398580005747	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
398580005748	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
398580005749	active site
398580005750	phosphorylation site [posttranslational modification]
398580005751	intermolecular recognition site; other site
398580005752	dimerization interface [polypeptide binding]; other site
398580005753	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
398580005754	DNA binding residues [nucleotide binding]
398580005755	dimerization interface [polypeptide binding]; other site
398580005756	choice-of-anchor C domain; Region: choice_anch_C; TIGR04362
398580005757	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
398580005758	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
398580005759	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
398580005760	mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479
398580005761	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
398580005762	Substrate binding site; other site
398580005763	Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050
398580005764	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
398580005765	active site
398580005766	Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632
398580005767	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
398580005768	HlyD family secretion protein; Region: HlyD_3; pfam13437
398580005769	phosphomannomutase CpsG; Provisional; Region: PRK15414
398580005770	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
398580005771	active site
398580005772	substrate binding site [chemical binding]; other site
398580005773	metal binding site [ion binding]; metal-binding site
398580005774	Alginate O-acetyl transferase AlgF; Region: AlgF; pfam11182
398580005775	Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696
398580005776	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
398580005777	active site
398580005778	Int/Topo IB signature motif; other site
398580005779	DNA binding site [nucleotide binding]
398580005780	Helix-turn-helix domain; Region: HTH_17; pfam12728
398580005781	AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287
398580005782	Primase C terminal 1 (PriCT-1); Region: PriCT_1; cl07362
398580005783	Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1),  6-pyrovoyl...; Region: TFold; cl00263
398580005784	putative transposase OrfB; Reviewed; Region: PHA02517
398580005785	HTH-like domain; Region: HTH_21; pfam13276
398580005786	Integrase core domain; Region: rve; pfam00665
398580005787	Integrase core domain; Region: rve_3; pfam13683
398580005788	Transposase; Region: HTH_Tnp_1; pfam01527
398580005789	large terminase protein; Provisional; Region: 17; PHA02533
398580005790	DNA methylase; Region: N6_N4_Mtase; cl17433
398580005791	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
398580005792	Domain of unknown function (DUF3883); Region: DUF3883; pfam13020
398580005793	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
398580005794	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304
398580005795	dimerization interface [polypeptide binding]; other site
398580005796	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
398580005797	dimer interface [polypeptide binding]; other site
398580005798	phosphorylation site [posttranslational modification]
398580005799	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
398580005800	ATP binding site [chemical binding]; other site
398580005801	Mg2+ binding site [ion binding]; other site
398580005802	G-X-G motif; other site
398580005803	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
398580005804	putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015
398580005805	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
398580005806	Walker A motif; other site
398580005807	ATP binding site [chemical binding]; other site
398580005808	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
398580005809	primosome assembly protein PriA; Validated; Region: PRK05580
398580005810	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
398580005811	ATP binding site [chemical binding]; other site
398580005812	putative Mg++ binding site [ion binding]; other site
398580005813	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
398580005814	active site
398580005815	intersubunit interactions; other site
398580005816	catalytic residue [active]
398580005817	Protein of unknown function, DUF484; Region: DUF484; cl17449
398580005818	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
398580005819	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
398580005820	active site
398580005821	DNA binding site [nucleotide binding]
398580005822	Int/Topo IB signature motif; other site
398580005823	phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340
398580005824	EamA-like transporter family; Region: EamA; cl17759
398580005825	Protein of unknown function (DUF3253); Region: DUF3253; pfam11625
398580005826	putative S-transferase; Provisional; Region: PRK11752
398580005827	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
398580005828	C-terminal domain interface [polypeptide binding]; other site
398580005829	GSH binding site (G-site) [chemical binding]; other site
398580005830	dimer interface [polypeptide binding]; other site
398580005831	C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292
398580005832	dimer interface [polypeptide binding]; other site
398580005833	N-terminal domain interface [polypeptide binding]; other site
398580005834	active site
398580005835	isoleucyl-tRNA synthetase; Provisional; Region: ileS; PRK13804
398580005836	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
398580005837	active site
398580005838	HIGH motif; other site
398580005839	nucleotide binding site [chemical binding]; other site
398580005840	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
398580005841	active site
398580005842	KMSKS motif; other site
398580005843	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
398580005844	tRNA binding surface [nucleotide binding]; other site
398580005845	anticodon binding site; other site
398580005846	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
398580005847	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
398580005848	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
398580005849	ligand binding site [chemical binding]; other site
398580005850	flexible hinge region; other site
398580005851	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
398580005852	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
398580005853	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
398580005854	hypothetical protein; Provisional; Region: PRK05415
398580005855	Domain of unknown function (DUF697); Region: DUF697; pfam05128
398580005856	YcjX-like family, DUF463; Region: DUF463; pfam04317
398580005857	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
398580005858	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
398580005859	dimerization interface 3.5A [polypeptide binding]; other site
398580005860	active site
398580005861	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
398580005862	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
398580005863	dimer interface [polypeptide binding]; other site
398580005864	conserved gate region; other site
398580005865	putative PBP binding loops; other site
398580005866	ABC-ATPase subunit interface; other site
398580005867	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
398580005868	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
398580005869	Walker A/P-loop; other site
398580005870	ATP binding site [chemical binding]; other site
398580005871	Q-loop/lid; other site
398580005872	ABC transporter signature motif; other site
398580005873	Walker B; other site
398580005874	D-loop; other site
398580005875	H-loop/switch region; other site
398580005876	NMT1/THI5 like; Region: NMT1; pfam09084
398580005877	GSCFA family; Region: GSCFA; pfam08885
398580005878	cytosine deaminase; Validated; Region: PRK07572
398580005879	Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293
398580005880	active site
398580005881	Methyltransferase domain; Region: Methyltransf_24; pfam13578
398580005882	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
398580005883	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
398580005884	TM-ABC transporter signature motif; other site
398580005885	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
398580005886	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
398580005887	TM-ABC transporter signature motif; other site
398580005888	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
398580005889	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
398580005890	Walker A/P-loop; other site
398580005891	ATP binding site [chemical binding]; other site
398580005892	Q-loop/lid; other site
398580005893	ABC transporter signature motif; other site
398580005894	Walker B; other site
398580005895	D-loop; other site
398580005896	H-loop/switch region; other site
398580005897	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
398580005898	Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353
398580005899	putative ligand binding site [chemical binding]; other site
398580005900	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
398580005901	Sulfotransferase family; Region: Sulfotransfer_3; pfam13469
398580005902	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
398580005903	HlyD family secretion protein; Region: HlyD_3; pfam13437
398580005904	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
398580005905	Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509
398580005906	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825
398580005907	classical (c) SDRs; Region: SDR_c; cd05233
398580005908	NAD(P) binding site [chemical binding]; other site
398580005909	active site
398580005910	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
398580005911	NADH(P)-binding; Region: NAD_binding_10; pfam13460
398580005912	NAD(P) binding site [chemical binding]; other site
398580005913	active site
398580005914	short chain dehydrogenase; Provisional; Region: PRK06197
398580005915	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
398580005916	NAD(P) binding site [chemical binding]; other site
398580005917	active site
398580005918	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
398580005919	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
398580005920	NAD(P) binding site [chemical binding]; other site
398580005921	active site
398580005922	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
398580005923	TPR motif; other site
398580005924	binding surface
398580005925	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
398580005926	TPR motif; other site
398580005927	TPR repeat; Region: TPR_11; pfam13414
398580005928	binding surface
398580005929	TPR repeat; Region: TPR_11; pfam13414
398580005930	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
398580005931	binding surface
398580005932	TPR motif; other site
398580005933	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
398580005934	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
398580005935	NAD(P) binding site [chemical binding]; other site
398580005936	active site
398580005937	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
398580005938	Uncharacterized conserved protein [Function unknown]; Region: COG3379
398580005939	Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663
398580005940	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
398580005941	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
398580005942	active site
398580005943	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
398580005944	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
398580005945	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
398580005946	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
398580005947	phosphate binding site [ion binding]; other site
398580005948	2-Nitropropane dioxygenase (NPD)-like domain, associated with polyketide synthases (PKS). NPD is part of the nitroalkaneoxidizing enzyme family, that catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and...; Region: NPD_PKS; cd04743
398580005949	FMN binding site [chemical binding]; other site
398580005950	substrate binding site [chemical binding]; other site
398580005951	putative catalytic residue [active]
398580005952	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
398580005953	3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304
398580005954	active site
398580005955	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
398580005956	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
398580005957	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
398580005958	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
398580005959	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
398580005960	ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953
398580005961	putative NADP binding site [chemical binding]; other site
398580005962	active site
398580005963	FkbH-like domain; Region: FkbH; TIGR01686
398580005964	Acid Phosphatase; Region: Acid_PPase; cl17256
398580005965	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
398580005966	E3 interaction surface; other site
398580005967	lipoyl attachment site [posttranslational modification]; other site
398580005968	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467
398580005969	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
398580005970	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
398580005971	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
398580005972	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
398580005973	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
398580005974	E3 interaction surface; other site
398580005975	lipoyl attachment site [posttranslational modification]; other site
398580005976	e3 binding domain; Region: E3_binding; pfam02817
398580005977	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
398580005978	pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405
398580005979	Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017
398580005980	dimer interface [polypeptide binding]; other site
398580005981	TPP-binding site [chemical binding]; other site
398580005982	Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410
398580005983	D-lactate dehydrogenase; Provisional; Region: PRK11183
398580005984	FAD binding domain; Region: FAD_binding_4; pfam01565
398580005985	D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330
398580005986	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181
398580005987	TRAP-type mannitol/chloroaromatic compound transport system, large permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT3; COG4664
398580005988	DctM-like transporters; Region: DctM; pfam06808
398580005989	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
398580005990	Transcriptional regulators [Transcription]; Region: FadR; COG2186
398580005991	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
398580005992	DNA-binding site [nucleotide binding]; DNA binding site
398580005993	FCD domain; Region: FCD; pfam07729
398580005994	MoxR-like ATPases [General function prediction only]; Region: COG0714
398580005995	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
398580005996	Walker A motif; other site
398580005997	ATP binding site [chemical binding]; other site
398580005998	Walker B motif; other site
398580005999	arginine finger; other site
398580006000	Putative metallopeptidase domain; Region: DUF2201_N; pfam13203
398580006001	VWA-like domain (DUF2201); Region: DUF2201; pfam09967
398580006002	metal ion-dependent adhesion site (MIDAS); other site
398580006003	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
398580006004	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
398580006005	substrate binding site [chemical binding]; other site
398580006006	dimer interface [polypeptide binding]; other site
398580006007	ATP binding site [chemical binding]; other site
398580006008	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
398580006009	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
398580006010	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
398580006011	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
398580006012	TM-ABC transporter signature motif; other site
398580006013	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
398580006014	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
398580006015	TM-ABC transporter signature motif; other site
398580006016	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
398580006017	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
398580006018	Walker A/P-loop; other site
398580006019	ATP binding site [chemical binding]; other site
398580006020	Q-loop/lid; other site
398580006021	ABC transporter signature motif; other site
398580006022	Walker B; other site
398580006023	D-loop; other site
398580006024	H-loop/switch region; other site
398580006025	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
398580006026	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
398580006027	Walker A/P-loop; other site
398580006028	ATP binding site [chemical binding]; other site
398580006029	Q-loop/lid; other site
398580006030	ABC transporter signature motif; other site
398580006031	Walker B; other site
398580006032	D-loop; other site
398580006033	H-loop/switch region; other site
398580006034	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
398580006035	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
398580006036	active site
398580006037	catalytic tetrad [active]
398580006038	TIGR04076 family protein; Region: TIGR04076
398580006039	Transcriptional regulators [Transcription]; Region: GntR; COG1802
398580006040	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
398580006041	DNA-binding site [nucleotide binding]; DNA binding site
398580006042	FCD domain; Region: FCD; pfam07729
398580006043	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
398580006044	active site
398580006045	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
398580006046	catalytic tetrad [active]
398580006047	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154
398580006048	homotrimer interaction site [polypeptide binding]; other site
398580006049	putative active site [active]
398580006050	Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838
398580006051	Monomeric isocitrate dehydrogenase; Region: IDH; cl15383
398580006052	Protein of unknown function (DUF2478); Region: DUF2478; pfam10649
398580006053	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
398580006054	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
398580006055	Phosphotransferase enzyme family; Region: APH; pfam01636
398580006056	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
398580006057	substrate binding site [chemical binding]; other site
398580006058	Phosphotransferase enzyme family; Region: APH; pfam01636
398580006059	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
398580006060	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
398580006061	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
398580006062	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
398580006063	Walker A/P-loop; other site
398580006064	ATP binding site [chemical binding]; other site
398580006065	Q-loop/lid; other site
398580006066	ABC transporter signature motif; other site
398580006067	Walker B; other site
398580006068	D-loop; other site
398580006069	H-loop/switch region; other site
398580006070	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
398580006071	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
398580006072	This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799
398580006073	colanic acid biosynthesis glycosyltransferase WcaL; Region: wcaL; TIGR04005
398580006074	putative ADP-binding pocket [chemical binding]; other site
398580006075	Predicted glycosyl transferase [General function prediction only]; Region: COG4671
398580006076	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
398580006077	xylose isomerase; Provisional; Region: PRK05474
398580006078	xylose isomerase; Region: xylose_isom_A; TIGR02630
398580006079	Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808
398580006080	N- and C-terminal domain interface [polypeptide binding]; other site
398580006081	D-xylulose kinase; Region: XylB; TIGR01312
398580006082	active site
398580006083	MgATP binding site [chemical binding]; other site
398580006084	catalytic site [active]
398580006085	metal binding site [ion binding]; metal-binding site
398580006086	xylulose binding site [chemical binding]; other site
398580006087	homodimer interface [polypeptide binding]; other site
398580006088	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
398580006089	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
398580006090	Walker A/P-loop; other site
398580006091	ATP binding site [chemical binding]; other site
398580006092	Q-loop/lid; other site
398580006093	ABC transporter signature motif; other site
398580006094	Walker B; other site
398580006095	D-loop; other site
398580006096	H-loop/switch region; other site
398580006097	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
398580006098	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
398580006099	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
398580006100	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
398580006101	TM-ABC transporter signature motif; other site
398580006102	Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538
398580006103	D-xylose ABC transporter, substrate-binding protein; Region: xylF; TIGR02634
398580006104	putative ligand binding site [chemical binding]; other site
398580006105	MarR family; Region: MarR_2; pfam12802
398580006106	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
398580006107	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
398580006108	Family description; Region: VCBS; pfam13517
398580006109	Family description; Region: VCBS; pfam13517
398580006110	Family description; Region: VCBS; pfam13517
398580006111	ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593
398580006112	Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208
398580006113	Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150
398580006114	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
398580006115	PAS fold; Region: PAS_3; pfam08447
398580006116	putative active site [active]
398580006117	heme pocket [chemical binding]; other site
398580006118	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_9; cd04666
398580006119	nudix motif; other site
398580006120	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
398580006121	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
398580006122	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
398580006123	ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221
398580006124	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
398580006125	phosphonate ABC transporter, ATP-binding protein; Region: ABC_phnC; TIGR02315
398580006126	ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256
398580006127	Walker A/P-loop; other site
398580006128	ATP binding site [chemical binding]; other site
398580006129	Q-loop/lid; other site
398580006130	ABC transporter signature motif; other site
398580006131	Walker B; other site
398580006132	D-loop; other site
398580006133	H-loop/switch region; other site
398580006134	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
398580006135	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
398580006136	dimer interface [polypeptide binding]; other site
398580006137	conserved gate region; other site
398580006138	ABC-ATPase subunit interface; other site
398580006139	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
398580006140	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
398580006141	ABC-ATPase subunit interface; other site
398580006142	Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647
398580006143	Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344
398580006144	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
398580006145	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
398580006146	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
398580006147	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
398580006148	dimer interface [polypeptide binding]; other site
398580006149	conserved gate region; other site
398580006150	putative PBP binding loops; other site
398580006151	ABC-ATPase subunit interface; other site
398580006152	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
398580006153	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
398580006154	dimer interface [polypeptide binding]; other site
398580006155	conserved gate region; other site
398580006156	putative PBP binding loops; other site
398580006157	ABC-ATPase subunit interface; other site
398580006158	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
398580006159	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
398580006160	Walker A/P-loop; other site
398580006161	ATP binding site [chemical binding]; other site
398580006162	Q-loop/lid; other site
398580006163	ABC transporter signature motif; other site
398580006164	Walker B; other site
398580006165	D-loop; other site
398580006166	H-loop/switch region; other site
398580006167	TOBE domain; Region: TOBE_2; pfam08402
398580006168	Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069
398580006169	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
398580006170	active site
398580006171	FMN binding site [chemical binding]; other site
398580006172	substrate binding site [chemical binding]; other site
398580006173	3Fe-4S cluster binding site [ion binding]; other site
398580006174	The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757
398580006175	phosphoglucomutase; Region: PLN02307
398580006176	active site
398580006177	substrate binding site [chemical binding]; other site
398580006178	metal binding site [ion binding]; metal-binding site
398580006179	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
398580006180	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
398580006181	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
398580006182	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
398580006183	dimer interface [polypeptide binding]; other site
398580006184	conserved gate region; other site
398580006185	putative PBP binding loops; other site
398580006186	ABC-ATPase subunit interface; other site
398580006187	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
398580006188	dimer interface [polypeptide binding]; other site
398580006189	conserved gate region; other site
398580006190	putative PBP binding loops; other site
398580006191	ABC-ATPase subunit interface; other site
398580006192	Protein of unknown function (DUF1498); Region: DUF1498; cl17840
398580006193	LamB/YcsF family of  lactam utilization protein; Region: LamB_YcsF_like; cd10787
398580006194	putative active site [active]
398580006195	Allophanate hydrolase subunit 2; Region: AHS2; pfam02626
398580006196	Allophanate hydrolase subunit 1; Region: AHS1; pfam02682
398580006197	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896
398580006198	Transcriptional regulators [Transcription]; Region: PurR; COG1609
398580006199	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
398580006200	DNA binding site [nucleotide binding]
398580006201	domain linker motif; other site
398580006202	This group includes the ligand-binding domain of putative DNA transcription repressors which are highly similar to that of the repressor specific for gluconate (GntR), a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR_like_1; cd06273
398580006203	putative dimerization interface [polypeptide binding]; other site
398580006204	putative ligand binding site [chemical binding]; other site
398580006205	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
398580006206	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
398580006207	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290
398580006208	DctM-like transporters; Region: DctM; pfam06808
398580006209	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
398580006210	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
398580006211	histidinol dehydrogenase; Region: hisD; TIGR00069
398580006212	NAD binding site [chemical binding]; other site
398580006213	dimerization interface [polypeptide binding]; other site
398580006214	product binding site; other site
398580006215	substrate binding site [chemical binding]; other site
398580006216	zinc binding site [ion binding]; other site
398580006217	catalytic residues [active]
398580006218	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825
398580006219	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
398580006220	NAD(P) binding site [chemical binding]; other site
398580006221	active site
398580006222	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
398580006223	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
398580006224	NAD(P) binding site [chemical binding]; other site
398580006225	Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613
398580006226	D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295
398580006227	Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055
398580006228	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
398580006229	Ligand Binding Site [chemical binding]; other site
398580006230	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
398580006231	aminotransferase; Validated; Region: PRK07678
398580006232	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
398580006233	inhibitor-cofactor binding pocket; inhibition site
398580006234	pyridoxal 5'-phosphate binding site [chemical binding]; other site
398580006235	catalytic residue [active]
398580006236	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
398580006237	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
398580006238	DNA-binding site [nucleotide binding]; DNA binding site
398580006239	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
398580006240	pyridoxal 5'-phosphate binding site [chemical binding]; other site
398580006241	homodimer interface [polypeptide binding]; other site
398580006242	catalytic residue [active]
398580006243	sulfoacetaldehyde acetyltransferase; Validated; Region: PRK07525
398580006244	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
398580006245	PYR/PP interface [polypeptide binding]; other site
398580006246	dimer interface [polypeptide binding]; other site
398580006247	TPP binding site [chemical binding]; other site
398580006248	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
398580006249	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
398580006250	TPP-binding site [chemical binding]; other site
398580006251	Acetate kinase [Energy production and conversion]; Region: ackA; COG0282
398580006252	propionate/acetate kinase; Provisional; Region: PRK12379
398580006253	Protein of unknown function (DUF330); Region: DUF330; cl01135
398580006254	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
398580006255	mce related protein; Region: MCE; pfam02470
398580006256	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
398580006257	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
398580006258	Walker A/P-loop; other site
398580006259	ATP binding site [chemical binding]; other site
398580006260	Q-loop/lid; other site
398580006261	ABC transporter signature motif; other site
398580006262	Walker B; other site
398580006263	D-loop; other site
398580006264	H-loop/switch region; other site
398580006265	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
398580006266	anti sigma factor interaction site; other site
398580006267	regulatory phosphorylation site [posttranslational modification]; other site
398580006268	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
398580006269	Permease; Region: Permease; pfam02405
398580006270	Hemin uptake protein hemP; Region: hemP; pfam10636
398580006271	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
398580006272	Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994
398580006273	active site
398580006274	Zn binding site [ion binding]; other site
398580006275	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
398580006276	catalytic residues [active]
398580006277	dimer interface [polypeptide binding]; other site
398580006278	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_9; cd04666
398580006279	nudix motif; other site
398580006280	Protein of unknown function (DUF1178); Region: DUF1178; pfam06676
398580006281	C factor cell-cell signaling protein; Provisional; Region: PRK09009
398580006282	carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325
398580006283	NADP binding site [chemical binding]; other site
398580006284	homodimer interface [polypeptide binding]; other site
398580006285	active site
398580006286	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
398580006287	Predicted kinase [General function prediction only]; Region: COG0645
398580006288	bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238
398580006289	Aconitate hydratase 2 N-terminus; Region: Aconitase_2_N; pfam06434
398580006290	substrate binding site [chemical binding]; other site
398580006291	Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285
398580006292	substrate binding site [chemical binding]; other site
398580006293	ligand binding site [chemical binding]; other site
398580006294	aspartate kinase; Reviewed; Region: PRK06635
398580006295	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
398580006296	putative nucleotide binding site [chemical binding]; other site
398580006297	putative catalytic residues [active]
398580006298	putative Mg ion binding site [ion binding]; other site
398580006299	putative aspartate binding site [chemical binding]; other site
398580006300	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
398580006301	putative allosteric regulatory site; other site
398580006302	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
398580006303	putative allosteric regulatory residue; other site
398580006304	Signal transduction protein containing GAF and PtsI domains [Signal transduction mechanisms]; Region: PtsP; COG3605
398580006305	GAF domain; Region: GAF; pfam01590
398580006306	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
398580006307	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
398580006308	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
398580006309	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
398580006310	metal ion-dependent adhesion site (MIDAS); other site
398580006311	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
398580006312	Coenzyme A binding pocket [chemical binding]; other site
398580006313	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
398580006314	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
398580006315	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
398580006316	Sulfate transporter family; Region: Sulfate_transp; pfam00916
398580006317	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
398580006318	5'-methylthioadenosine phosphorylase; Provisional; Region: PRK08931
398580006319	Ribbon-helix-helix domain; Region: RHH_4; pfam13467
398580006320	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
398580006321	dimer interface [polypeptide binding]; other site
398580006322	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
398580006323	active site
398580006324	metal binding site [ion binding]; metal-binding site
398580006325	glutathione binding site [chemical binding]; other site
398580006326	Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618
398580006327	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
398580006328	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
398580006329	Jacalin-like lectin domain of griffithsin and related proteins; Region: griffithsin_like; cd09614
398580006330	sugar binding site [chemical binding]; other site
398580006331	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
398580006332	active site
398580006333	Domain of unknown function DUF302; Region: DUF302; pfam03625
398580006334	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
398580006335	FAD binding domain; Region: FAD_binding_4; pfam01565
398580006336	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
398580006337	Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483
398580006338	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
398580006339	triosephosphate isomerase; Provisional; Region: PRK14565
398580006340	substrate binding site [chemical binding]; other site
398580006341	dimer interface [polypeptide binding]; other site
398580006342	catalytic triad [active]
398580006343	Transcriptional regulator [Transcription]; Region: LysR; COG0583
398580006344	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
398580006345	The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441
398580006346	putative dimerization interface [polypeptide binding]; other site
398580006347	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
398580006348	FAD binding site [chemical binding]; other site
398580006349	Cytochrome c; Region: Cytochrom_C; cl11414
398580006350	Cytochrome c; Region: Cytochrom_C; cl11414
398580006351	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
398580006352	putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604
398580006353	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
398580006354	CoenzymeA binding site [chemical binding]; other site
398580006355	subunit interaction site [polypeptide binding]; other site
398580006356	PHB binding site; other site
398580006357	Uncharacterized conserved protein (DUF2235); Region: DUF2235; pfam09994
398580006358	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
398580006359	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
398580006360	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
398580006361	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
398580006362	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
398580006363	active site
398580006364	HIGH motif; other site
398580006365	nucleotide binding site [chemical binding]; other site
398580006366	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
398580006367	active site
398580006368	KMSKS motif; other site
398580006369	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
398580006370	tRNA binding surface [nucleotide binding]; other site
398580006371	anticodon binding site; other site
398580006372	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
398580006373	histidinol-phosphate aminotransferase; Provisional; Region: PRK08153
398580006374	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
398580006375	pyridoxal 5'-phosphate binding site [chemical binding]; other site
398580006376	homodimer interface [polypeptide binding]; other site
398580006377	catalytic residue [active]
398580006378	Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075
398580006379	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
398580006380	catalytic residue [active]
398580006381	GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Region: GT_2_like_a; cd02522
398580006382	transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283
398580006383	Probable Catalytic site; other site
398580006384	Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354
398580006385	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
398580006386	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
398580006387	Domain of unknown function (DUF4399); Region: DUF4399; pfam14347
398580006388	elongation factor P; Validated; Region: PRK00529
398580006389	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
398580006390	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
398580006391	RNA binding site [nucleotide binding]; other site
398580006392	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
398580006393	RNA binding site [nucleotide binding]; other site
398580006394	cobyric acid synthase; Provisional; Region: PRK00784
398580006395	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
398580006396	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
398580006397	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
398580006398	catalytic triad [active]
398580006399	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
398580006400	Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518
398580006401	Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868
398580006402	FAD binding pocket [chemical binding]; other site
398580006403	conserved FAD binding motif [chemical binding]; other site
398580006404	phosphate binding motif [ion binding]; other site
398580006405	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
398580006406	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
398580006407	active site
398580006408	DNA binding site [nucleotide binding]
398580006409	Int/Topo IB signature motif; other site
398580006410	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
398580006411	DNA methylase; Region: N6_N4_Mtase; cl17433
398580006412	Transposase; Region: HTH_Tnp_1; pfam01527
398580006413	putative transposase OrfB; Reviewed; Region: PHA02517
398580006414	HTH-like domain; Region: HTH_21; pfam13276
398580006415	Integrase core domain; Region: rve; pfam00665
398580006416	Integrase core domain; Region: rve_3; pfam13683
398580006417	DNA methylase; Region: N6_N4_Mtase; cl17433
398580006418	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
398580006419	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
398580006420	non-specific DNA binding site [nucleotide binding]; other site
398580006421	salt bridge; other site
398580006422	sequence-specific DNA binding site [nucleotide binding]; other site
398580006423	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
398580006424	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
398580006425	ligand binding site [chemical binding]; other site
398580006426	flexible hinge region; other site
398580006427	Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616
398580006428	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 1; Region: PLPDE_III_DSD_D-TA_like_1; cd06812
398580006429	dimer interface [polypeptide binding]; other site
398580006430	active site
398580006431	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
398580006432	substrate binding site [chemical binding]; other site
398580006433	catalytic residue [active]
398580006434	Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227
398580006435	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
398580006436	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
398580006437	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
398580006438	putative active site [active]
398580006439	putative substrate binding site [chemical binding]; other site
398580006440	putative cosubstrate binding site; other site
398580006441	catalytic site [active]
398580006442	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
398580006443	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
398580006444	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
398580006445	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
398580006446	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
398580006447	dimer interface [polypeptide binding]; other site
398580006448	active site
398580006449	glycine-pyridoxal phosphate binding site [chemical binding]; other site
398580006450	folate binding site [chemical binding]; other site
398580006451	Sarcosine oxidase gamma subunit [Amino acid transport and metabolism]; Region: COG4583
398580006452	sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372
398580006453	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510
398580006454	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
398580006455	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
398580006456	Sarcosine oxidase delta subunit [Amino acid transport and metabolism]; Region: SoxD; COG4311
398580006457	sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373
398580006458	hydroxyglutarate oxidase; Provisional; Region: PRK11728
398580006459	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
398580006460	AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136
398580006461	conserved cys residue [active]
398580006462	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
398580006463	BCCT family transporter; Region: BCCT; pfam02028
398580006464	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
398580006465	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
398580006466	Walker A/P-loop; other site
398580006467	ATP binding site [chemical binding]; other site
398580006468	Q-loop/lid; other site
398580006469	ABC transporter signature motif; other site
398580006470	Walker B; other site
398580006471	D-loop; other site
398580006472	H-loop/switch region; other site
398580006473	TOBE domain; Region: TOBE_2; pfam08402
398580006474	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
398580006475	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
398580006476	dimer interface [polypeptide binding]; other site
398580006477	conserved gate region; other site
398580006478	putative PBP binding loops; other site
398580006479	ABC-ATPase subunit interface; other site
398580006480	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
398580006481	dimer interface [polypeptide binding]; other site
398580006482	conserved gate region; other site
398580006483	putative PBP binding loops; other site
398580006484	ABC-ATPase subunit interface; other site
398580006485	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
398580006486	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
398580006487	Creatinine amidohydrolase; Region: Creatininase; pfam02633
398580006488	Transcriptional regulator [Transcription]; Region: LysR; COG0583
398580006489	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
398580006490	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
398580006491	dimerization interface [polypeptide binding]; other site
398580006492	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
398580006493	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
398580006494	Creatine amidinohydrolase. E.C.3.5.3.3. Hydrolyzes creatine to sarcosine and urea; Region: Creatinase; cd01090
398580006495	active site
398580006496	Cupin domain; Region: Cupin_2; cl17218
398580006497	Paraquat-inducible protein A; Region: PqiA; pfam04403
398580006498	DNA repair protein RadA; Provisional; Region: PRK11823
398580006499	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
398580006500	Walker A motif/ATP binding site; other site
398580006501	ATP binding site [chemical binding]; other site
398580006502	Walker B motif; other site
398580006503	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
398580006504	Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286
398580006505	Colicin V production protein; Region: Colicin_V; pfam02674
398580006506	amidophosphoribosyltransferase; Provisional; Region: PRK09123
398580006507	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
398580006508	active site
398580006509	tetramer interface [polypeptide binding]; other site
398580006510	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
398580006511	active site
398580006512	Protein of unknown function (DUF1284); Region: DUF1284; pfam06935
398580006513	BioY family; Region: BioY; pfam02632
398580006514	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
398580006515	NAD(P) binding site [chemical binding]; other site
398580006516	stationary phase survival protein SurE; Provisional; Region: PRK13931
398580006517	protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312
398580006518	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
398580006519	S-adenosylmethionine binding site [chemical binding]; other site
398580006520	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
398580006521	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
398580006522	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
398580006523	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
398580006524	Peptidase family M23; Region: Peptidase_M23; pfam01551
398580006525	EamA-like transporter family; Region: EamA; pfam00892
398580006526	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
398580006527	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
398580006528	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
398580006529	Protein of unknown function (DUF533); Region: DUF533; pfam04391
398580006530	tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178
398580006531	putative metal binding site [ion binding]; other site
398580006532	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
398580006533	metal binding site 2 [ion binding]; metal-binding site
398580006534	putative DNA binding helix; other site
398580006535	metal binding site 1 [ion binding]; metal-binding site
398580006536	dimer interface [polypeptide binding]; other site
398580006537	structural Zn2+ binding site [ion binding]; other site
398580006538	Pirin-related protein [General function prediction only]; Region: COG1741
398580006539	Pirin; Region: Pirin; pfam02678
398580006540	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
398580006541	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
398580006542	Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008
398580006543	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
398580006544	catalytic residue [active]
398580006545	enolase; Provisional; Region: eno; PRK00077
398580006546	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
398580006547	dimer interface [polypeptide binding]; other site
398580006548	metal binding site [ion binding]; metal-binding site
398580006549	substrate binding pocket [chemical binding]; other site
398580006550	EamA-like transporter family; Region: EamA; pfam00892
398580006551	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
398580006552	Cupin superfamily (DUF985); Region: Cupin_5; pfam06172
398580006553	anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585
398580006554	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
398580006555	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
398580006556	active site
398580006557	HIGH motif; other site
398580006558	dimer interface [polypeptide binding]; other site
398580006559	KMSKS motif; other site
398580006560	Protein of unknown function (DUF3179); Region: DUF3179; pfam11376
398580006561	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
398580006562	active site
398580006563	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
398580006564	active site
398580006565	Phosphoglycerate kinase; Region: PGK; pfam00162
398580006566	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
398580006567	substrate binding site [chemical binding]; other site
398580006568	hinge regions; other site
398580006569	ADP binding site [chemical binding]; other site
398580006570	catalytic site [active]
398580006571	fructose-1,6-bisphosphate aldolase; Reviewed; Region: PRK05377
398580006572	catalytic residue [active]
398580006573	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182
398580006574	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
398580006575	tetramer interface [polypeptide binding]; other site
398580006576	TPP-binding site [chemical binding]; other site
398580006577	heterodimer interface [polypeptide binding]; other site
398580006578	phosphorylation loop region [posttranslational modification]
398580006579	pyruvate dehydrogenase subunit beta; Provisional; Region: PRK11892
398580006580	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
398580006581	E3 interaction surface; other site
398580006582	lipoyl attachment site [posttranslational modification]; other site
398580006583	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
398580006584	alpha subunit interface [polypeptide binding]; other site
398580006585	TPP binding site [chemical binding]; other site
398580006586	heterodimer interface [polypeptide binding]; other site
398580006587	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
398580006588	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
398580006589	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
398580006590	E3 interaction surface; other site
398580006591	lipoyl attachment site [posttranslational modification]; other site
398580006592	e3 binding domain; Region: E3_binding; pfam02817
398580006593	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
398580006594	serine acetyltransferase; Provisional; Region: cysE; PRK11132
398580006595	Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426
398580006596	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
398580006597	trimer interface [polypeptide binding]; other site
398580006598	active site
398580006599	substrate binding site [chemical binding]; other site
398580006600	CoA binding site [chemical binding]; other site
398580006601	Protein of unknown function (DUF2793); Region: DUF2793; pfam10983
398580006602	GTA TIM-barrel-like domain; Region: GTA_TIM; pfam13547
398580006603	Putative phage tail protein; Region: Phage-tail_3; pfam13550
398580006604	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
398580006605	NlpC/P60 family; Region: NLPC_P60; cl17555
398580006606	Uncharacterized conserved protein (DUF2163); Region: DUF2163; pfam09931
398580006607	phage conserved hypothetical protein BR0599; Region: phg_TIGR02218
398580006608	Phage conserved hypothetical protein BR0599; Region: Phage_BR0599; pfam09356
398580006609	Conserved hypothetical protein 2217 (DUF2460); Region: DUF2460; pfam09343
398580006610	Phage-related minor tail protein [Function unknown]; Region: COG5281
398580006611	Protein of unknown function (DUF3356); Region: DUF3356; pfam11836
398580006612	Phage major tail protein 2; Region: Phage_tail_2; cl11463
398580006613	Protein of unknown function (DUF3168); Region: DUF3168; pfam11367
398580006614	Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521
398580006615	phage conserved hypothetical protein, phiE125 gp8 family; Region: phage_chp_gp8; TIGR02215
398580006616	Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054
398580006617	Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054
398580006618	oligomerization interface [polypeptide binding]; other site
398580006619	phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554
398580006620	Phage capsid family; Region: Phage_capsid; pfam05065
398580006621	Caudovirus prohead protease; Region: Peptidase_U35; pfam04586
398580006622	Phage-related protein [Function unknown]; Region: COG4695
398580006623	Phage portal protein; Region: Phage_portal; pfam04860
398580006624	Uncharacterized conserved protein [Function unknown]; Region: COG5323
398580006625	Terminase-like family; Region: Terminase_6; pfam03237
398580006626	YceG-like family; Region: YceG; pfam02618
398580006627	proteins similar to Escherichia coli yceG; Region: yceG_like; cl17666
398580006628	dimerization interface [polypeptide binding]; other site
398580006629	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314
398580006630	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
398580006631	dimer interface [polypeptide binding]; other site
398580006632	active site
398580006633	acyl carrier protein; Provisional; Region: acpP; PRK00982
398580006634	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
398580006635	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
398580006636	NAD(P) binding site [chemical binding]; other site
398580006637	active site
398580006638	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
398580006639	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
398580006640	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
398580006641	YceI-like domain; Region: YceI; pfam04264
398580006642	Uncharacterized conserved protein [Function unknown]; Region: COG2353
398580006643	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
398580006644	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
398580006645	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
398580006646	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
398580006647	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
398580006648	bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420
398580006649	Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410
398580006650	active site
398580006651	metal binding site [ion binding]; metal-binding site
398580006652	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
398580006653	trigger factor; Provisional; Region: tig; PRK01490
398580006654	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
398580006655	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
398580006656	ETC complex I subunit conserved region; Region: ETC_C1_NDUFA4; pfam04800
398580006657	excinuclease ABC subunit B; Provisional; Region: PRK05298
398580006658	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
398580006659	ATP binding site [chemical binding]; other site
398580006660	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
398580006661	nucleotide binding region [chemical binding]; other site
398580006662	ATP-binding site [chemical binding]; other site
398580006663	Ultra-violet resistance protein B; Region: UvrB; pfam12344
398580006664	UvrB/uvrC motif; Region: UVR; pfam02151
398580006665	Domain of unknown function (DUF4415); Region: DUF4415; pfam14384
398580006666	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
398580006667	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
398580006668	Walker A/P-loop; other site
398580006669	ATP binding site [chemical binding]; other site
398580006670	Q-loop/lid; other site
398580006671	ABC transporter signature motif; other site
398580006672	Walker B; other site
398580006673	D-loop; other site
398580006674	H-loop/switch region; other site
398580006675	ABC transporter; Region: ABC_tran_2; pfam12848
398580006676	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
398580006677	MOSC domain; Region: MOSC; pfam03473
398580006678	Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794
398580006679	aspartate racemase; Region: asp_race; TIGR00035
398580006680	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
398580006681	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
398580006682	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
398580006683	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
398580006684	Cytidylyltransferase; Region: CTP_transf_2; pfam01467
398580006685	active site
398580006686	(T/H)XGH motif; other site
398580006687	tellurite resistance protein terB; Region: terB; cd07176
398580006688	putative metal binding site [ion binding]; other site
398580006689	lysyl-tRNA synthetase; Reviewed; Region: lysK; PRK00750
398580006690	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
398580006691	active site
398580006692	nucleotide binding site [chemical binding]; other site
398580006693	HIGH motif; other site
398580006694	KMSKS motif; other site
398580006695	D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429
398580006696	Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006
398580006697	Domain of unknown function (DUF427); Region: DUF427; pfam04248
398580006698	Pyridoxamine 5'-phosphate oxidase; Region: Pyrid_oxidase_2; pfam13883
398580006699	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
398580006700	Ligand Binding Site [chemical binding]; other site
398580006701	Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992
398580006702	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
398580006703	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
398580006704	P-loop; other site
398580006705	Magnesium ion binding site [ion binding]; other site
398580006706	Transcription factor zinc-finger; Region: zf-TFIIB; cl01565
398580006707	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
398580006708	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
398580006709	DNA-binding site [nucleotide binding]; DNA binding site
398580006710	RNA-binding motif; other site
398580006711	tellurium resistance terB-like protein, subgroup 2; Region: terB_like_2; cd07313
398580006712	putative metal binding site [ion binding]; other site
398580006713	ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598
398580006714	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
398580006715	Walker A/P-loop; other site
398580006716	ATP binding site [chemical binding]; other site
398580006717	Q-loop/lid; other site
398580006718	ABC transporter signature motif; other site
398580006719	Walker B; other site
398580006720	D-loop; other site
398580006721	H-loop/switch region; other site
398580006722	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
398580006723	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
398580006724	substrate binding pocket [chemical binding]; other site
398580006725	membrane-bound complex binding site; other site
398580006726	hinge residues; other site
398580006727	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
398580006728	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
398580006729	ABC-ATPase subunit interface; other site
398580006730	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
398580006731	dimer interface [polypeptide binding]; other site
398580006732	conserved gate region; other site
398580006733	putative PBP binding loops; other site
398580006734	ABC-ATPase subunit interface; other site
398580006735	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
398580006736	catalytic triad [active]
398580006737	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
398580006738	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
398580006739	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
398580006740	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
398580006741	DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041
398580006742	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
398580006743	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
398580006744	catalytic residue [active]
398580006745	Transcriptional regulator [Transcription]; Region: LysR; COG0583
398580006746	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
398580006747	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
398580006748	dimerization interface [polypeptide binding]; other site
398580006749	polyhydroxyalkanoate synthesis repressor PhaR; Region: PHA_reg_PhaR; TIGR01848
398580006750	PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879
398580006751	PHB accumulation regulatory domain; Region: PHB_acc; pfam05233
398580006752	poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838
398580006753	Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167
398580006754	polyhydroxyalkanoate depolymerase, intracellular; Region: PHB_depoly_PhaZ; TIGR01849
398580006755	PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850
398580006756	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
398580006757	substrate binding site [chemical binding]; other site
398580006758	THF binding site; other site
398580006759	zinc-binding site [ion binding]; other site
398580006760	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
398580006761	SnoaL-like domain; Region: SnoaL_2; pfam12680
398580006762	Transcriptional regulators [Transcription]; Region: PurR; COG1609
398580006763	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
398580006764	DNA binding site [nucleotide binding]
398580006765	domain linker motif; other site
398580006766	Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_2; cd06278
398580006767	putative dimerization interface [polypeptide binding]; other site
398580006768	putative ligand binding site [chemical binding]; other site
398580006769	short chain dehydrogenase; Provisional; Region: PRK07060
398580006770	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
398580006771	NAD(P) binding site [chemical binding]; other site
398580006772	active site
398580006773	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
398580006774	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
398580006775	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
398580006776	histidinol dehydrogenase; Region: hisD; TIGR00069
398580006777	NAD binding site [chemical binding]; other site
398580006778	dimerization interface [polypeptide binding]; other site
398580006779	product binding site; other site
398580006780	substrate binding site [chemical binding]; other site
398580006781	zinc binding site [ion binding]; other site
398580006782	catalytic residues [active]
398580006783	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
398580006784	Protein of unknown function (DUF1052); Region: DUF1052; cl02197
398580006785	DDE superfamily endonuclease; Region: DDE_3; pfam13358
398580006786	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
398580006787	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
398580006788	Homeodomain-like domain; Region: HTH_23; cl17451
398580006789	transcription antitermination factor NusB; Region: nusB; TIGR01951
398580006790	putative RNA binding site [nucleotide binding]; other site
398580006791	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
398580006792	homopentamer interface [polypeptide binding]; other site
398580006793	active site
398580006794	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019
398580006795	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
398580006796	GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925
398580006797	dimerization interface [polypeptide binding]; other site
398580006798	active site
398580006799	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
398580006800	Lumazine binding domain; Region: Lum_binding; pfam00677
398580006801	Lumazine binding domain; Region: Lum_binding; pfam00677
398580006802	Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsS; COG3562
398580006803	Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159
398580006804	Vi polysaccharide export protein VexA; Provisional; Region: PRK15175
398580006805	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
398580006806	Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159
398580006807	Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159
398580006808	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
398580006809	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
398580006810	catalytic motif [active]
398580006811	Zn binding site [ion binding]; other site
398580006812	RibD C-terminal domain; Region: RibD_C; cl17279
398580006813	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
398580006814	ATP cone domain; Region: ATP-cone; pfam03477
398580006815	Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894
398580006816	RNA polymerase sigma factor RpoD; Validated; Region: PRK05658
398580006817	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
398580006818	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
398580006819	Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546
398580006820	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
398580006821	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
398580006822	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
398580006823	DNA binding residues [nucleotide binding]
398580006824	DNA primase, catalytic core; Region: dnaG; TIGR01391
398580006825	CHC2 zinc finger; Region: zf-CHC2; cl17510
398580006826	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
398580006827	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
398580006828	active site
398580006829	metal binding site [ion binding]; metal-binding site
398580006830	interdomain interaction site; other site
398580006831	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
398580006832	Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893
398580006833	sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372
398580006834	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510
398580006835	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
398580006836	Sarcosine oxidase, delta subunit family; Region: SoxD; pfam04267
398580006837	sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373
398580006838	Putative Flp pilus-assembly TadE/G-like; Region: Tad; pfam13400
398580006839	TadE-like protein; Region: TadE; pfam07811
398580006840	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
398580006841	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
398580006842	homoserine dehydrogenase; Provisional; Region: PRK06349
398580006843	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
398580006844	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
398580006845	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
398580006846	Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516
398580006847	Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320
398580006848	putative active site [active]
398580006849	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
398580006850	DHH family; Region: DHH; pfam01368
398580006851	Protein of unknown function (DUF2478); Region: DUF2478; pfam10649
398580006852	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
398580006853	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
398580006854	dimer interface [polypeptide binding]; other site
398580006855	putative functional site; other site
398580006856	putative MPT binding site; other site
398580006857	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
398580006858	molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509
398580006859	molybdopterin cofactor binding site; other site
398580006860	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929
398580006861	molybdopterin cofactor binding site; other site
398580006862	DNA-binding transcriptional regulator TorR; Provisional; Region: PRK10766
398580006863	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
398580006864	active site
398580006865	phosphorylation site [posttranslational modification]
398580006866	intermolecular recognition site; other site
398580006867	dimerization interface [polypeptide binding]; other site
398580006868	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
398580006869	DNA binding site [nucleotide binding]
398580006870	TMAO reductase sytem sensor TorS; Region: TMAO_torS; TIGR02956
398580006871	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
398580006872	dimerization interface [polypeptide binding]; other site
398580006873	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
398580006874	dimer interface [polypeptide binding]; other site
398580006875	phosphorylation site [posttranslational modification]
398580006876	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
398580006877	ATP binding site [chemical binding]; other site
398580006878	Mg2+ binding site [ion binding]; other site
398580006879	G-X-G motif; other site
398580006880	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
398580006881	active site
398580006882	phosphorylation site [posttranslational modification]
398580006883	intermolecular recognition site; other site
398580006884	dimerization interface [polypeptide binding]; other site
398580006885	TMAO reductase system periplasmic protein TorT; Region: TMAO_TorT; TIGR02955
398580006886	TorT-like proteins, a periplasmic binding protein family that activates induction of the Tor respiratory system upon trimethylamine N-oxide (TMAO) electron-acceptor binding in bacteria; Region: PBP1_TorT-like; cd06306
398580006887	putative ligand binding site [chemical binding]; other site
398580006888	Helix-turn-helix domain; Region: HTH_18; pfam12833
398580006889	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
398580006890	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
398580006891	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
398580006892	Beta-lactamase; Region: Beta-lactamase; pfam00144
398580006893	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
398580006894	Protein of unknown function (DUF3299); Region: DUF3299; pfam11736
398580006895	Transcriptional regulators [Transcription]; Region: MarR; COG1846
398580006896	MarR family; Region: MarR_2; pfam12802
398580006897	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274
398580006898	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
398580006899	TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358
398580006900	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
398580006901	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
398580006902	Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299
398580006903	active site
398580006904	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
398580006905	Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; cl01604
398580006906	META domain; Region: META; pfam03724
398580006907	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
398580006908	HlyD family secretion protein; Region: HlyD; pfam00529
398580006909	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
398580006910	HlyD family secretion protein; Region: HlyD_3; pfam13437
398580006911	membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074
398580006912	Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280
398580006913	Trp docking motif [polypeptide binding]; other site
398580006914	putative active site [active]
398580006915	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
398580006916	Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299
398580006917	active site
398580006918	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
398580006919	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
398580006920	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
398580006921	Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457
398580006922	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase-like 1; Region: PLPDE_III_AR_like_1; cd06815
398580006923	dimer interface [polypeptide binding]; other site
398580006924	active site
398580006925	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
398580006926	substrate binding site [chemical binding]; other site
398580006927	catalytic residue [active]
398580006928	Protein of unknown function (DUF1611); Region: DUF1611; pfam07755
398580006929	NnrS protein; Region: NnrS; pfam05940
398580006930	Hemerythrin-like domain; Region: Hr-like; cd12108
398580006931	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
398580006932	apolar tunnel; other site
398580006933	heme binding site [chemical binding]; other site
398580006934	dimerization interface [polypeptide binding]; other site
398580006935	Rrf2 family protein; Region: rrf2_super; TIGR00738
398580006936	Transcriptional regulator; Region: Rrf2; cl17282
398580006937	Hexameric tyrosine-coordinated heme protein (HTHP); Region: HTHP; pfam11534
398580006938	Arginase family; Region: Arginase; cd09989
398580006939	active site
398580006940	Mn binding site [ion binding]; other site
398580006941	oligomer interface [polypeptide binding]; other site
398580006942	ornithine cyclodeaminase; Validated; Region: PRK07589
398580006943	ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400
398580006944	bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11905
398580006945	Proline dehydrogenase; Region: Pro_dh; pfam01619
398580006946	Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125
398580006947	Glutamate binding site [chemical binding]; other site
398580006948	NAD binding site [chemical binding]; other site
398580006949	catalytic residues [active]
398580006950	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
398580006951	NAD(P) binding site [chemical binding]; other site
398580006952	Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872
398580006953	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
398580006954	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
398580006955	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
398580006956	dimer interface [polypeptide binding]; other site
398580006957	pyridoxal 5'-phosphate binding site [chemical binding]; other site
398580006958	catalytic residue [active]
398580006959	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
398580006960	putative active site pocket [active]
398580006961	dimerization interface [polypeptide binding]; other site
398580006962	putative catalytic residue [active]
398580006963	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
398580006964	dimer interface [polypeptide binding]; other site
398580006965	ADP-ribose binding site [chemical binding]; other site
398580006966	active site
398580006967	nudix motif; other site
398580006968	metal binding site [ion binding]; metal-binding site
398580006969	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
398580006970	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
398580006971	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
398580006972	S-adenosylmethionine binding site [chemical binding]; other site
398580006973	Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415
398580006974	DNA photolyase; Region: DNA_photolyase; pfam00875
398580006975	Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288
398580006976	putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823
398580006977	NADP binding site [chemical binding]; other site
398580006978	dimer interface [polypeptide binding]; other site
398580006979	putative dimethyl sulfoniopropionate demethylase; Reviewed; Region: dmdA; PRK12486
398580006980	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
398580006981	DinB family; Region: DinB; cl17821
398580006982	DinB superfamily; Region: DinB_2; pfam12867
398580006983	Protein of unknown function (DUF1326); Region: DUF1326; pfam07040
398580006984	Predicted metal-binding integral membrane protein (DUF2182); Region: DUF2182; pfam09948
398580006985	Transcriptional regulators [Transcription]; Region: FadR; COG2186
398580006986	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
398580006987	DNA-binding site [nucleotide binding]; DNA binding site
398580006988	FCD domain; Region: FCD; pfam07729
398580006989	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
398580006990	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
398580006991	Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675
398580006992	Phage Tail Collar Domain; Region: Collar; pfam07484
398580006993	Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675
398580006994	Phage Tail Collar Domain; Region: Collar; pfam07484
398580006995	Protein of unknown function (DUF1194); Region: DUF1194; pfam06707
398580006996	Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
398580006997	Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059
398580006998	chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937
398580006999	Chromate transporter; Region: Chromate_transp; pfam02417
398580007000	Stringent starvation protein B; Region: SspB; pfam04386
398580007001	fumarate hydratase; Reviewed; Region: fumC; PRK00485
398580007002	Class II fumarases; Region: Fumarase_classII; cd01362
398580007003	active site
398580007004	tetramer interface [polypeptide binding]; other site
398580007005	Ribbon-helix-helix domain; Region: RHH_4; pfam13467
398580007006	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
398580007007	Cytochrome P450; Region: p450; cl12078
398580007008	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
398580007009	CPxP  motif; other site
398580007010	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
398580007011	Ribonuclease E/G family; Region: RNase_E_G; pfam10150
398580007012	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274
398580007013	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274
398580007014	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181
398580007015	TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663
398580007016	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
398580007017	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4564
398580007018	Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049
398580007019	Histidine kinase; Region: HisKA_3; pfam07730
398580007020	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
398580007021	ATP binding site [chemical binding]; other site
398580007022	Mg2+ binding site [ion binding]; other site
398580007023	G-X-G motif; other site
398580007024	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
398580007025	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
398580007026	active site
398580007027	phosphorylation site [posttranslational modification]
398580007028	intermolecular recognition site; other site
398580007029	dimerization interface [polypeptide binding]; other site
398580007030	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
398580007031	DNA binding residues [nucleotide binding]
398580007032	dimerization interface [polypeptide binding]; other site
398580007033	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
398580007034	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
398580007035	Transcriptional regulator [Transcription]; Region: LysR; COG0583
398580007036	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
398580007037	The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417
398580007038	substrate binding pocket [chemical binding]; other site
398580007039	dimerization interface [polypeptide binding]; other site
398580007040	FeS assembly SUF system protein; Region: SUF_assoc; TIGR02945
398580007041	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
398580007042	MoeA_like. This domain is similar to a domain found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. There this domain is presumed to bind molybdopterin. The exact function of this subgroup is...; Region: MoeA_like; cd03522
398580007043	putative MPT binding site; other site
398580007044	Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975
398580007045	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
398580007046	XdhC Rossmann domain; Region: XdhC_C; pfam13478
398580007047	Protein of unknown function (DUF1800); Region: DUF1800; pfam08811
398580007048	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4102
398580007049	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
398580007050	Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552
398580007051	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
398580007052	metal ion-dependent adhesion site (MIDAS); other site
398580007053	MoxR-like ATPases [General function prediction only]; Region: COG0714
398580007054	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
398580007055	Walker A motif; other site
398580007056	ATP binding site [chemical binding]; other site
398580007057	Walker B motif; other site
398580007058	arginine finger; other site
398580007059	Glutaryl-CoA dehydrogenase; Region: GCD; cd01151
398580007060	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
398580007061	FAD binding site [chemical binding]; other site
398580007062	substrate binding pocket [chemical binding]; other site
398580007063	catalytic base [active]
398580007064	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
398580007065	bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase precursor protein; Reviewed; Region: PRK11907
398580007066	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
398580007067	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
398580007068	Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830
398580007069	UreF; Region: UreF; pfam01730
398580007070	urease accessory protein UreE; Provisional; Region: ureE; PRK13261
398580007071	UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571
398580007072	dimer interface [polypeptide binding]; other site
398580007073	catalytic residues [active]
398580007074	urease subunit alpha; Reviewed; Region: ureC; PRK13207
398580007075	Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375
398580007076	subunit interactions [polypeptide binding]; other site
398580007077	active site
398580007078	flap region; other site
398580007079	Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407
398580007080	gamma-beta subunit interface [polypeptide binding]; other site
398580007081	alpha-beta subunit interface [polypeptide binding]; other site
398580007082	Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390
398580007083	alpha-gamma subunit interface [polypeptide binding]; other site
398580007084	beta-gamma subunit interface [polypeptide binding]; other site
398580007085	UreD urease accessory protein; Region: UreD; pfam01774
398580007086	Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294
398580007087	active site
398580007088	substrate binding pocket [chemical binding]; other site
398580007089	dimer interface [polypeptide binding]; other site
398580007090	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
398580007091	active site
398580007092	replicative DNA helicase; Provisional; Region: PRK09165
398580007093	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
398580007094	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
398580007095	Walker A motif; other site
398580007096	ATP binding site [chemical binding]; other site
398580007097	Walker B motif; other site
398580007098	DNA binding loops [nucleotide binding]
398580007099	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304
398580007100	dimerization interface [polypeptide binding]; other site
398580007101	Protein of unknown function (DUF1194); Region: DUF1194; pfam06707
398580007102	Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211
398580007103	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
398580007104	Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787
398580007105	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
398580007106	active site
398580007107	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
398580007108	dimer interface [polypeptide binding]; other site
398580007109	substrate binding site [chemical binding]; other site
398580007110	catalytic residues [active]
398580007111	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
398580007112	Permease; Region: Permease; pfam02405
398580007113	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
398580007114	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
398580007115	Walker A/P-loop; other site
398580007116	ATP binding site [chemical binding]; other site
398580007117	Q-loop/lid; other site
398580007118	ABC transporter signature motif; other site
398580007119	Walker B; other site
398580007120	D-loop; other site
398580007121	H-loop/switch region; other site
398580007122	lipoate-protein ligase B; Provisional; Region: PRK14341
398580007123	Methyltransferase domain; Region: Methyltransf_23; pfam13489
398580007124	Methyltransferase domain; Region: Methyltransf_11; pfam08241
398580007125	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
398580007126	Cytochrome C oxidase subunit I.  Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663
398580007127	Subunit I/III interface [polypeptide binding]; other site
398580007128	D-pathway; other site
398580007129	Subunit I/VIIc interface [polypeptide binding]; other site
398580007130	Subunit I/IV interface [polypeptide binding]; other site
398580007131	Subunit I/II interface [polypeptide binding]; other site
398580007132	Low-spin heme (heme a) binding site [chemical binding]; other site
398580007133	Subunit I/VIIa interface [polypeptide binding]; other site
398580007134	Subunit I/VIa interface [polypeptide binding]; other site
398580007135	Dimer interface; other site
398580007136	Putative water exit pathway; other site
398580007137	Binuclear center (heme a3/CuB) [ion binding]; other site
398580007138	K-pathway; other site
398580007139	Subunit I/Vb interface [polypeptide binding]; other site
398580007140	Putative proton exit pathway; other site
398580007141	Subunit I/VIb interface; other site
398580007142	Subunit I/VIc interface [polypeptide binding]; other site
398580007143	Electron transfer pathway; other site
398580007144	Subunit I/VIIIb interface [polypeptide binding]; other site
398580007145	Subunit I/VIIb interface [polypeptide binding]; other site
398580007146	Integral membrane protein (DUF2244); Region: DUF2244; pfam10003
398580007147	Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755
398580007148	Yqey-like protein; Region: YqeY; cl17540
398580007149	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
398580007150	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988
398580007151	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
398580007152	catalytic site [active]
398580007153	subunit interface [polypeptide binding]; other site
398580007154	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
398580007155	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
398580007156	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
398580007157	active site
398580007158	Transcriptional regulators [Transcription]; Region: GntR; COG1802
398580007159	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
398580007160	DNA-binding site [nucleotide binding]; DNA binding site
398580007161	FCD domain; Region: FCD; pfam07729
398580007162	pyrimidine 5'-nucleotidase; Region: Pyr-5-nucltdase; TIGR01993
398580007163	?-D-glucose-1-phosphatase; Provisional; Region: PRK09456
398580007164	2-octaprenyl-6-methoxyphenyl hydroxylase; Provisional; Region: PRK07494
398580007165	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
398580007166	Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075
398580007167	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
398580007168	catalytic residue [active]
398580007169	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
398580007170	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
398580007171	putative DNA binding site [nucleotide binding]; other site
398580007172	putative Zn2+ binding site [ion binding]; other site
398580007173	AsnC family; Region: AsnC_trans_reg; pfam01037
398580007174	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
398580007175	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
398580007176	AsnC family; Region: AsnC_trans_reg; pfam01037
398580007177	ketol-acid reductoisomerase; Provisional; Region: PRK05479
398580007178	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
398580007179	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
398580007180	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14315
398580007181	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
398580007182	active site
398580007183	substrate binding site [chemical binding]; other site
398580007184	metal binding site [ion binding]; metal-binding site
398580007185	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
398580007186	dihydropteroate synthase; Region: DHPS; TIGR01496
398580007187	substrate binding pocket [chemical binding]; other site
398580007188	dimer interface [polypeptide binding]; other site
398580007189	inhibitor binding site; inhibition site
398580007190	Dihydroneopterin aldolase; Region: FolB; smart00905
398580007191	active site
398580007192	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
398580007193	Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486
398580007194	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
398580007195	pyruvate phosphate dikinase; Provisional; Region: PRK09279
398580007196	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
398580007197	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
398580007198	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
398580007199	glycyl-tRNA synthetase subunit alpha; Validated; Region: glyQ; PRK09348
398580007200	motif 1; other site
398580007201	dimer interface [polypeptide binding]; other site
398580007202	active site
398580007203	motif 2; other site
398580007204	motif 3; other site
398580007205	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
398580007206	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
398580007207	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
398580007208	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
398580007209	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
398580007210	GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972
398580007211	C-terminal domain interface [polypeptide binding]; other site
398580007212	GSH binding site (G-site) [chemical binding]; other site
398580007213	dimer interface [polypeptide binding]; other site
398580007214	C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291
398580007215	N-terminal domain interface [polypeptide binding]; other site
398580007216	putative dimer interface [polypeptide binding]; other site
398580007217	active site
398580007218	O-succinylhomoserine sulfhydrylase; Reviewed; Region: PRK07504
398580007219	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
398580007220	homodimer interface [polypeptide binding]; other site
398580007221	substrate-cofactor binding pocket; other site
398580007222	pyridoxal 5'-phosphate binding site [chemical binding]; other site
398580007223	catalytic residue [active]
398580007224	putative GTP cyclohydrolase; Provisional; Region: PRK13674
398580007225	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
398580007226	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
398580007227	Cl- selectivity filter; other site
398580007228	Cl- binding residues [ion binding]; other site
398580007229	pore gating glutamate residue; other site
398580007230	dimer interface [polypeptide binding]; other site
398580007231	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
398580007232	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
398580007233	Walker A/P-loop; other site
398580007234	ATP binding site [chemical binding]; other site
398580007235	Q-loop/lid; other site
398580007236	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
398580007237	ABC transporter signature motif; other site
398580007238	Walker B; other site
398580007239	D-loop; other site
398580007240	H-loop/switch region; other site
398580007241	outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302
398580007242	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186
398580007243	UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331
398580007244	cell division protein FtsZ; Validated; Region: PRK09330
398580007245	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
398580007246	nucleotide binding site [chemical binding]; other site
398580007247	SulA interaction site; other site
398580007248	cell division protein FtsA; Region: ftsA; TIGR01174
398580007249	Cell division protein FtsA; Region: FtsA; smart00842
398580007250	Cell division protein FtsA; Region: FtsA; pfam14450
398580007251	Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589
398580007252	Cell division protein FtsQ; Region: FtsQ; pfam03799
398580007253	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
398580007254	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
398580007255	ATP-grasp domain; Region: ATP-grasp_4; cl17255
398580007256	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
398580007257	FAD binding domain; Region: FAD_binding_4; pfam01565
398580007258	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
398580007259	Protein of unknown function (DUF2484); Region: DUF2484; pfam10658
398580007260	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
398580007261	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
398580007262	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
398580007263	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
398580007264	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
398580007265	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
398580007266	active site
398580007267	homodimer interface [polypeptide binding]; other site
398580007268	cell division protein FtsW; Region: ftsW; TIGR02614
398580007269	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
398580007270	Peptidase S8 family domain, uncharacterized subfamily 4; Region: Peptidases_S8_4; cd05561
398580007271	active site
398580007272	catalytic triad [active]
398580007273	RNA polymerase sigma factor; Provisional; Region: PRK12515
398580007274	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
398580007275	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
398580007276	DNA binding residues [nucleotide binding]
398580007277	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
398580007278	Novosphingobium aromaticivorans carbohydrate kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_NaCK_like; cd07772
398580007279	N- and C-terminal domain interface [polypeptide binding]; other site
398580007280	putative active site [active]
398580007281	putative MgATP binding site [chemical binding]; other site
398580007282	putative catalytic site [active]
398580007283	metal binding site [ion binding]; metal-binding site
398580007284	putative carbohydrate binding site [chemical binding]; other site
398580007285	Domain of unknown function (DUF718); Region: DUF718; pfam05336
398580007286	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
398580007287	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
398580007288	TM-ABC transporter signature motif; other site
398580007289	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
398580007290	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
398580007291	TM-ABC transporter signature motif; other site
398580007292	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
398580007293	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
398580007294	Walker A/P-loop; other site
398580007295	ATP binding site [chemical binding]; other site
398580007296	Q-loop/lid; other site
398580007297	ABC transporter signature motif; other site
398580007298	Walker B; other site
398580007299	D-loop; other site
398580007300	H-loop/switch region; other site
398580007301	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
398580007302	rhamnose ABC transporter, rhamnose-binding protein; Region: RhaS; TIGR02637
398580007303	Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302
398580007304	ligand binding site [chemical binding]; other site
398580007305	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
398580007306	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
398580007307	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
398580007308	short chain dehydrogenase; Validated; Region: PRK08324
398580007309	Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007
398580007310	rhamnulose-1-phosphate aldolase/alcohol dehydrogenase, classical (c) SDRs; Region: R1PA_ADH_SDR_c; cd08943
398580007311	putative NAD(P) binding site [chemical binding]; other site
398580007312	active site
398580007313	L-rhamnose isomerase; Provisional; Region: PRK01076
398580007314	Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900
398580007315	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
398580007316	Amidohydrolase; Region: Amidohydro_2; pfam04909
398580007317	Tripartite tricarboxylate transporter TctA family; Region: TctA; pfam01970
398580007318	Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331
398580007319	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
398580007320	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
398580007321	Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129
398580007322	dimer interface [polypeptide binding]; other site
398580007323	NADP binding site [chemical binding]; other site
398580007324	catalytic residues [active]
398580007325	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
398580007326	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
398580007327	4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232
398580007328	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
398580007329	Transcriptional regulators [Transcription]; Region: GntR; COG1802
398580007330	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
398580007331	DNA-binding site [nucleotide binding]; DNA binding site
398580007332	FCD domain; Region: FCD; pfam07729
398580007333	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
398580007334	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
398580007335	inhibitor site; inhibition site
398580007336	active site
398580007337	dimer interface [polypeptide binding]; other site
398580007338	catalytic residue [active]
398580007339	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
398580007340	Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 2. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_2; cd03327
398580007341	putative active site pocket [active]
398580007342	putative metal binding site [ion binding]; other site
398580007343	Tripartite tricarboxylate transporter TctA family; Region: TctA; pfam01970
398580007344	Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331
398580007345	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
398580007346	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01390
398580007347	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
398580007348	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
398580007349	YegX is an uncharacterized bacterial protein with a glycosyl hydrolase family 25 (GH25) catalytic domain that is similar in sequence to the CH-type (Chalaropsis-type) lysozymes of the GH25 family of endolysins; Region: GH25_YegX-like; cd06524
398580007350	Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183
398580007351	active site
398580007352	Protein of unknown function (DUF4255); Region: DUF4255; pfam14065
398580007353	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
398580007354	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
398580007355	Walker A motif; other site
398580007356	ATP binding site [chemical binding]; other site
398580007357	Walker B motif; other site
398580007358	arginine finger; other site
398580007359	Gene 25-like lysozyme; Region: GPW_gp25; pfam04965
398580007360	PAAR motif; Region: PAAR_motif; pfam05488
398580007361	Phage protein D [General function prediction only]; Region: COG3500
398580007362	Rhs element Vgr protein; Region: vgr_GE; TIGR01646
398580007363	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
398580007364	Protein of unknown function (DUF2807); Region: DUF2807; pfam10988
398580007365	T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841
398580007366	T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841
398580007367	Phage tail sheath protein; Region: Phage_sheath_1; cl01389
398580007368	Phage tail sheath protein FI [General function prediction only]; Region: COG3497
398580007369	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
398580007370	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
398580007371	Mg++ binding site [ion binding]; other site
398580007372	putative catalytic motif [active]
398580007373	putative substrate binding site [chemical binding]; other site
398580007374	UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate--D-alanyl-D-alanine ligase; Provisional; Region: PRK14093
398580007375	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
398580007376	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
398580007377	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
398580007378	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
398580007379	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
398580007380	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
398580007381	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
398580007382	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
398580007383	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
398580007384	Predicted secreted (periplasmic) protein [Function unknown]; Region: COG5462
398580007385	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
398580007386	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
398580007387	S-adenosylmethionine binding site [chemical binding]; other site
398580007388	cell division protein MraZ; Reviewed; Region: PRK00326
398580007389	MraZ protein; Region: MraZ; pfam02381
398580007390	MraZ protein; Region: MraZ; pfam02381
398580007391	Domain of unknown function DUF59; Region: DUF59; pfam01883
398580007392	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
398580007393	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
398580007394	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
398580007395	putative DNA binding site [nucleotide binding]; other site
398580007396	putative Zn2+ binding site [ion binding]; other site
398580007397	AsnC family; Region: AsnC_trans_reg; pfam01037
398580007398	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
398580007399	Transcriptional regulator [Transcription]; Region: LysR; COG0583
398580007400	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
398580007401	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
398580007402	putative effector binding pocket; other site
398580007403	dimerization interface [polypeptide binding]; other site
398580007404	short chain dehydrogenase; Provisional; Region: PRK12744
398580007405	tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362
398580007406	NADP binding site [chemical binding]; other site
398580007407	homodimer interface [polypeptide binding]; other site
398580007408	active site
398580007409	substrate binding site [chemical binding]; other site
398580007410	EthD domain; Region: EthD; cl17553
398580007411	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
398580007412	Part of AAA domain; Region: AAA_19; pfam13245
398580007413	Family description; Region: UvrD_C_2; pfam13538
398580007414	L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197
398580007415	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
398580007416	phosphate binding site [ion binding]; other site
398580007417	pyruvate carboxylase; Reviewed; Region: PRK12999
398580007418	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
398580007419	ATP-grasp domain; Region: ATP-grasp_4; cl17255
398580007420	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
398580007421	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
398580007422	active site
398580007423	catalytic residues [active]
398580007424	metal binding site [ion binding]; metal-binding site
398580007425	homodimer binding site [polypeptide binding]; other site
398580007426	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
398580007427	carboxyltransferase (CT) interaction site; other site
398580007428	biotinylation site [posttranslational modification]; other site
398580007429	Protein of unknown function (DUF1826); Region: DUF1826; pfam08856
398580007430	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
398580007431	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
398580007432	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
398580007433	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
398580007434	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
398580007435	non-specific DNA binding site [nucleotide binding]; other site
398580007436	salt bridge; other site
398580007437	sequence-specific DNA binding site [nucleotide binding]; other site
398580007438	Predicted transcriptional regulator [General function prediction only]; Region: COG3800
398580007439	Domain of unknown function (DUF955); Region: DUF955; pfam06114
398580007440	Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856
398580007441	Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451
398580007442	homodimer interface [polypeptide binding]; other site
398580007443	pyridoxal 5'-phosphate binding site [chemical binding]; other site
398580007444	catalytic residue [active]
398580007445	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
398580007446	malate--CoA ligase subunit beta; Provisional; Region: PRK14046
398580007447	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
398580007448	CoA-ligase; Region: Ligase_CoA; pfam00549
398580007449	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
398580007450	CoA binding domain; Region: CoA_binding; smart00881
398580007451	CoA-ligase; Region: Ligase_CoA; pfam00549
398580007452	Uncharacterized conserved protein [Function unknown]; Region: COG3777
398580007453	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
398580007454	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
398580007455	active site 2 [active]
398580007456	active site 1 [active]
398580007457	mesaconyl-CoA isomerase; Region: mesacon_CoA_iso; TIGR04253
398580007458	CoA-transferase family III; Region: CoA_transf_3; pfam02515
398580007459	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
398580007460	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302
398580007461	Ca2+ binding site [ion binding]; other site
398580007462	osmolarity response regulator; Provisional; Region: ompR; PRK09468
398580007463	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
398580007464	active site
398580007465	phosphorylation site [posttranslational modification]
398580007466	intermolecular recognition site; other site
398580007467	dimerization interface [polypeptide binding]; other site
398580007468	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
398580007469	DNA binding site [nucleotide binding]
398580007470	HAMP domain; Region: HAMP; pfam00672
398580007471	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
398580007472	dimer interface [polypeptide binding]; other site
398580007473	phosphorylation site [posttranslational modification]
398580007474	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
398580007475	ATP binding site [chemical binding]; other site
398580007476	Mg2+ binding site [ion binding]; other site
398580007477	G-X-G motif; other site
398580007478	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
398580007479	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
398580007480	ligand binding site [chemical binding]; other site
398580007481	type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375
398580007482	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296
398580007483	putative active site [active]
398580007484	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
398580007485	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
398580007486	Walker A/P-loop; other site
398580007487	ATP binding site [chemical binding]; other site
398580007488	Q-loop/lid; other site
398580007489	ABC transporter signature motif; other site
398580007490	Walker B; other site
398580007491	D-loop; other site
398580007492	H-loop/switch region; other site
398580007493	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
398580007494	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
398580007495	HlyD family secretion protein; Region: HlyD_3; pfam13437
398580007496	Protein of unknown function (DUF3987); Region: DUF3987; pfam13148
398580007497	Transposase; Region: HTH_Tnp_1; pfam01527
398580007498	putative transposase OrfB; Reviewed; Region: PHA02517
398580007499	HTH-like domain; Region: HTH_21; pfam13276
398580007500	Integrase core domain; Region: rve; pfam00665
398580007501	Integrase core domain; Region: rve_3; pfam13683
398580007502	HTH-like domain; Region: HTH_21; pfam13276
398580007503	Integrase core domain; Region: rve; pfam00665
398580007504	Transposase; Region: HTH_Tnp_1; pfam01527
398580007505	tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815
398580007506	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
398580007507	FMN binding site [chemical binding]; other site
398580007508	active site
398580007509	catalytic residues [active]
398580007510	substrate binding site [chemical binding]; other site
398580007511	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
398580007512	high affinity sulphate transporter 1; Region: sulP; TIGR00815
398580007513	Sulfate transporter family; Region: Sulfate_transp; pfam00916
398580007514	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
398580007515	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
398580007516	Predicted transporter component [General function prediction only]; Region: COG2391
398580007517	Sulphur transport; Region: Sulf_transp; pfam04143
398580007518	Domain of unknown function (DUF4341); Region: DUF4341; pfam14241
398580007519	Protein of unknown function (DUF2892); Region: DUF2892; pfam11127
398580007520	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
398580007521	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
398580007522	ligand binding site [chemical binding]; other site
398580007523	flexible hinge region; other site
398580007524	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
398580007525	putative switch regulator; other site
398580007526	non-specific DNA interactions [nucleotide binding]; other site
398580007527	DNA binding site [nucleotide binding]
398580007528	sequence specific DNA binding site [nucleotide binding]; other site
398580007529	putative cAMP binding site [chemical binding]; other site
398580007530	peroxiredoxin; Provisional; Region: PRK13189
398580007531	Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016
398580007532	dimer interface [polypeptide binding]; other site
398580007533	decamer (pentamer of dimers) interface [polypeptide binding]; other site
398580007534	catalytic triad [active]
398580007535	Transcriptional regulator [Transcription]; Region: LysR; COG0583
398580007536	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
398580007537	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
398580007538	dimerization interface [polypeptide binding]; other site
398580007539	Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes SLAC1 (Slow Anion Channel-Associated 1); Region: TDT_SLAC1_like; cd09323
398580007540	gating phenylalanine in ion channel; other site
398580007541	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
398580007542	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
398580007543	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
398580007544	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
398580007545	Tripartite tricarboxylate transporter TctA family; Region: TctA; pfam01970
398580007546	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
398580007547	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
398580007548	Transcriptional regulators [Transcription]; Region: FadR; COG2186
398580007549	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
398580007550	DNA-binding site [nucleotide binding]; DNA binding site
398580007551	FCD domain; Region: FCD; pfam07729
398580007552	Transcriptional regulators [Transcription]; Region: FadR; COG2186
398580007553	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
398580007554	DNA-binding site [nucleotide binding]; DNA binding site
398580007555	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
398580007556	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
398580007557	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
398580007558	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
398580007559	NMT1/THI5 like; Region: NMT1; pfam09084
398580007560	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
398580007561	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
398580007562	Walker A/P-loop; other site
398580007563	ATP binding site [chemical binding]; other site
398580007564	Q-loop/lid; other site
398580007565	ABC transporter signature motif; other site
398580007566	Walker B; other site
398580007567	D-loop; other site
398580007568	H-loop/switch region; other site
398580007569	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
398580007570	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
398580007571	dimer interface [polypeptide binding]; other site
398580007572	conserved gate region; other site
398580007573	ABC-ATPase subunit interface; other site
398580007574	Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055
398580007575	Domain of unknown function (DUF4157); Region: DUF4157; pfam13699
398580007576	Phage-related protein [Function unknown]; Region: COG5412
398580007577	Domain of unknown function (DUF4157); Region: DUF4157; pfam13699
398580007578	Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cd00102
398580007579	Y-family of DNA polymerases; Region: PolY; cl12025
398580007580	conserved hypothetical protein, phage tail-like region; Region: TIGR02243
398580007581	conserved hypothetical protein, phage tail-like region; Region: TIGR02243
398580007582	Gene 25-like lysozyme; Region: GPW_gp25; pfam04965
398580007583	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
398580007584	chaperonin_like superfamily. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. There are 2 main chaperonin groups. The symmetry of type I...; Region: chaperonin_like; cl02777
398580007585	Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796
398580007586	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
398580007587	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
398580007588	Walker A motif; other site
398580007589	ATP binding site [chemical binding]; other site
398580007590	Walker B motif; other site
398580007591	arginine finger; other site
398580007592	Protein of unknown function (DUF4255); Region: DUF4255; pfam14065
398580007593	T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841
398580007594	Phage tail sheath protein; Region: Phage_sheath_1; cl01389
398580007595	Phage tail sheath protein FI [General function prediction only]; Region: COG3497
398580007596	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
398580007597	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
398580007598	active site
398580007599	phosphorylation site [posttranslational modification]
398580007600	intermolecular recognition site; other site
398580007601	dimerization interface [polypeptide binding]; other site
398580007602	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
398580007603	dimerization interface [polypeptide binding]; other site
398580007604	DNA binding residues [nucleotide binding]
398580007605	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182
398580007606	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
398580007607	tetramer interface [polypeptide binding]; other site
398580007608	TPP-binding site [chemical binding]; other site
398580007609	heterodimer interface [polypeptide binding]; other site
398580007610	phosphorylation loop region [posttranslational modification]
398580007611	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
398580007612	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
398580007613	alpha subunit interface [polypeptide binding]; other site
398580007614	TPP binding site [chemical binding]; other site
398580007615	heterodimer interface [polypeptide binding]; other site
398580007616	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
398580007617	Cache domain; Region: Cache_1; pfam02743
398580007618	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
398580007619	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
398580007620	putative active site [active]
398580007621	heme pocket [chemical binding]; other site
398580007622	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
398580007623	dimer interface [polypeptide binding]; other site
398580007624	phosphorylation site [posttranslational modification]
398580007625	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
398580007626	ATP binding site [chemical binding]; other site
398580007627	G-X-G motif; other site
398580007628	Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566
398580007629	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
398580007630	active site
398580007631	phosphorylation site [posttranslational modification]
398580007632	intermolecular recognition site; other site
398580007633	dimerization interface [polypeptide binding]; other site
398580007634	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
398580007635	DNA binding residues [nucleotide binding]
398580007636	dimerization interface [polypeptide binding]; other site
398580007637	Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180
398580007638	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
398580007639	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
398580007640	Transcriptional regulators [Transcription]; Region: GntR; COG1802
398580007641	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
398580007642	DNA-binding site [nucleotide binding]; DNA binding site
398580007643	FCD domain; Region: FCD; pfam07729
398580007644	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
398580007645	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
398580007646	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
398580007647	Predicted CoA-binding protein [General function prediction only]; Region: COG1832
398580007648	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
398580007649	metal binding site [ion binding]; metal-binding site
398580007650	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
398580007651	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
398580007652	substrate binding site [chemical binding]; other site
398580007653	glutamase interaction surface [polypeptide binding]; other site
398580007654	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
398580007655	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
398580007656	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
398580007657	phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007
398580007658	catalytic residues [active]
398580007659	Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917
398580007660	ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970
398580007661	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
398580007662	ATP binding site [chemical binding]; other site
398580007663	putative Mg++ binding site [ion binding]; other site
398580007664	helicase superfamily c-terminal domain; Region: HELICc; smart00490
398580007665	Helicase associated domain (HA2) Add an annotation; Region: HA2; smart00847
398580007666	ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482
398580007667	Protein of unknown function (DUF3108); Region: DUF3108; pfam11306
398580007668	membrane ATPase/protein kinase; Provisional; Region: PRK09435
398580007669	Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249
398580007670	GTP/Mg2+ binding site [chemical binding]; other site
398580007671	G4 box; other site
398580007672	G5 box; other site
398580007673	The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114
398580007674	Walker A; other site
398580007675	G1 box; other site
398580007676	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
398580007677	Protein of unknown function (DUF461); Region: DUF461; pfam04314
398580007678	HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231
398580007679	putative exonuclease, DNA ligase-associated; Region: Xnuc_lig_assoc; TIGR04122
398580007680	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
398580007681	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
398580007682	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
398580007683	ATP-dependent DNA ligase; Validated; Region: PRK09247
398580007684	Adenylation domain of putative bacterial ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_Bac1; cd07897
398580007685	active site
398580007686	DNA binding site [nucleotide binding]
398580007687	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972
398580007688	DNA binding site [nucleotide binding]
398580007689	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
398580007690	active site
398580007691	DNA binding site [nucleotide binding]
398580007692	Int/Topo IB signature motif; other site
398580007693	Predicted transcriptional regulator [Transcription]; Region: COG1959
398580007694	Transcriptional regulator; Region: Rrf2; pfam02082
398580007695	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
398580007696	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
398580007697	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
398580007698	Protein of unknown function (DUF1826); Region: DUF1826; pfam08856
398580007699	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
398580007700	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_3; cd08490
398580007701	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
398580007702	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
398580007703	Q-loop/lid; other site
398580007704	ABC transporter signature motif; other site
398580007705	Walker B; other site
398580007706	D-loop; other site
398580007707	H-loop/switch region; other site
398580007708	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
398580007709	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
398580007710	Walker A/P-loop; other site
398580007711	ATP binding site [chemical binding]; other site
398580007712	Q-loop/lid; other site
398580007713	ABC transporter signature motif; other site
398580007714	Walker B; other site
398580007715	D-loop; other site
398580007716	H-loop/switch region; other site
398580007717	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
398580007718	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
398580007719	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
398580007720	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
398580007721	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
398580007722	putative PBP binding loops; other site
398580007723	ABC-ATPase subunit interface; other site
398580007724	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
398580007725	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
398580007726	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
398580007727	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
398580007728	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
398580007729	active site
398580007730	oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290
398580007731	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_5; cd09610
398580007732	active site
398580007733	Zn binding site [ion binding]; other site
398580007734	Protein of unknown function (DUF805); Region: DUF805; pfam05656
398580007735	Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360
398580007736	Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360
398580007737	Domain of unknown function (DUF4389); Region: DUF4389; pfam14333
398580007738	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
398580007739	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
398580007740	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
398580007741	RNA polymerase factor sigma-32; Reviewed; Region: PRK06596
398580007742	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
398580007743	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
398580007744	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
398580007745	DNA binding residues [nucleotide binding]
398580007746	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
398580007747	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
398580007748	RNA binding surface [nucleotide binding]; other site
398580007749	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
398580007750	active site
398580007751	NAD-dependent deacetylase; Provisional; Region: PRK00481
398580007752	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
398580007753	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
398580007754	Low molecular weight phosphatase family; Region: LMWPc; cd00115
398580007755	active site
398580007756	ABC-2 type transporter; Region: ABC2_membrane; cl17235
398580007757	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
398580007758	GcrA cell cycle regulator; Region: GcrA; cl11564
398580007759	GcrA cell cycle regulator; Region: GcrA; cl11564
398580007760	ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862
398580007761	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
398580007762	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
398580007763	FeS/SAM binding site; other site
398580007764	Uncharacterized protein involved in tolerance to divalent cations [Inorganic ion transport and metabolism]; Region: CutA; COG1324
398580007765	Peptidase family M48; Region: Peptidase_M48; cl12018
398580007766	Protein of unknown function, DUF393; Region: DUF393; pfam04134
398580007767	Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135
398580007768	putative FMN binding site [chemical binding]; other site
398580007769	Etoposide-induced protein 2.4 (EI24); Region: EI24; pfam07264
398580007770	Protein of unknown function (DUF1467); Region: DUF1467; pfam07330
398580007771	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
398580007772	Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249
398580007773	dimer interface [polypeptide binding]; other site
398580007774	substrate binding site [chemical binding]; other site
398580007775	metal binding site [ion binding]; metal-binding site
398580007776	Response regulator receiver domain; Region: Response_reg; pfam00072
398580007777	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
398580007778	active site
398580007779	phosphorylation site [posttranslational modification]
398580007780	intermolecular recognition site; other site
398580007781	dimerization interface [polypeptide binding]; other site
398580007782	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
398580007783	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
398580007784	dimer interface [polypeptide binding]; other site
398580007785	anticodon binding site; other site
398580007786	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
398580007787	motif 1; other site
398580007788	dimer interface [polypeptide binding]; other site
398580007789	active site
398580007790	motif 2; other site
398580007791	GAD domain; Region: GAD; pfam02938
398580007792	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
398580007793	active site
398580007794	motif 3; other site
398580007795	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
398580007796	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
398580007797	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
398580007798	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
398580007799	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
398580007800	V4R domain; Region: V4R; cl15268
398580007801	magnesium-protoporphyrin IX monomethyl ester anaerobic oxidative cyclase; Region: BchE; TIGR02026
398580007802	B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068
398580007803	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
398580007804	FeS/SAM binding site; other site
398580007805	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
398580007806	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
398580007807	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
398580007808	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
398580007809	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
398580007810	ATP-grasp domain; Region: ATP-grasp_4; cl17255
398580007811	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
398580007812	IMP binding site; other site
398580007813	dimer interface [polypeptide binding]; other site
398580007814	partial ornithine binding site; other site
398580007815	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
398580007816	thymidine kinase; Provisional; Region: PRK04296
398580007817	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
398580007818	D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301
398580007819	dimerization interface [polypeptide binding]; other site
398580007820	ligand binding site [chemical binding]; other site
398580007821	NADP binding site [chemical binding]; other site
398580007822	catalytic site [active]
398580007823	tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798
398580007824	dimer interface [polypeptide binding]; other site
398580007825	putative tRNA-binding site [nucleotide binding]; other site
398580007826	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
398580007827	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
398580007828	Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722
398580007829	Membrane fusogenic activity; Region: BMFP; pfam04380
398580007830	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
398580007831	Uncharacterized conserved protein [Function unknown]; Region: COG1565
398580007832	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
398580007833	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578
398580007834	Hint domain; Region: Hint_2; pfam13403
398580007835	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
398580007836	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
398580007837	putative DNA binding site [nucleotide binding]; other site
398580007838	putative Zn2+ binding site [ion binding]; other site
398580007839	AsnC family; Region: AsnC_trans_reg; pfam01037
398580007840	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
398580007841	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
398580007842	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
398580007843	Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150
398580007844	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
398580007845	Transcriptional regulators [Transcription]; Region: MarR; COG1846
398580007846	bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Validated; Region: PRK05537
398580007847	ATP-sulfurylase; Region: ATPS; cd00517
398580007848	active site
398580007849	HXXH motif; other site
398580007850	flexible loop; other site
398580007851	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
398580007852	ligand-binding site [chemical binding]; other site
398580007853	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
398580007854	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092
398580007855	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
398580007856	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
398580007857	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
398580007858	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
398580007859	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
398580007860	catalytic loop [active]
398580007861	iron binding site [ion binding]; other site
398580007862	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
398580007863	Carbon monoxide dehydrogenase subunit G (CoxG); Region: CoxG; cd05018
398580007864	putative hydrophobic ligand binding site [chemical binding]; other site
398580007865	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
398580007866	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
398580007867	substrate binding pocket [chemical binding]; other site
398580007868	membrane-bound complex binding site; other site
398580007869	hinge residues; other site
398580007870	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
398580007871	Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268
398580007872	ligand binding site [chemical binding]; other site
398580007873	PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866
398580007874	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
398580007875	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
398580007876	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
398580007877	ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864
398580007878	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
398580007879	Walker A/P-loop; other site
398580007880	ATP binding site [chemical binding]; other site
398580007881	Q-loop/lid; other site
398580007882	ABC transporter signature motif; other site
398580007883	Walker B; other site
398580007884	D-loop; other site
398580007885	H-loop/switch region; other site
398580007886	ABC-2 type transporter; Region: ABC2_membrane; cl17235
398580007887	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
398580007888	cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673
398580007889	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
398580007890	Walker A/P-loop; other site
398580007891	ATP binding site [chemical binding]; other site
398580007892	Q-loop/lid; other site
398580007893	ABC transporter signature motif; other site
398580007894	Walker B; other site
398580007895	D-loop; other site
398580007896	H-loop/switch region; other site
398580007897	NMT1/THI5 like; Region: NMT1; pfam09084
398580007898	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
398580007899	substrate binding pocket [chemical binding]; other site
398580007900	membrane-bound complex binding site; other site
398580007901	Cytochrome c; Region: Cytochrom_C; cl11414
398580007902	PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075
398580007903	Ethanol dehydrogenase, a bacterial quinoprotein (PQQ-dependent type I alcohol dehydrogenase); Region: PQQ_ADH_I; cd10277
398580007904	dimer interface [polypeptide binding]; other site
398580007905	Trp docking motif [polypeptide binding]; other site
398580007906	active site
398580007907	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
398580007908	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
398580007909	active site
398580007910	phosphorylation site [posttranslational modification]
398580007911	intermolecular recognition site; other site
398580007912	dimerization interface [polypeptide binding]; other site
398580007913	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
398580007914	DNA binding residues [nucleotide binding]
398580007915	dimerization interface [polypeptide binding]; other site
398580007916	Uncharacterized conserved protein [Function unknown]; Region: COG3287
398580007917	FIST N domain; Region: FIST; pfam08495
398580007918	FIST C domain; Region: FIST_C; pfam10442
398580007919	PAS fold; Region: PAS_7; pfam12860
398580007920	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
398580007921	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
398580007922	dimer interface [polypeptide binding]; other site
398580007923	phosphorylation site [posttranslational modification]
398580007924	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
398580007925	ATP binding site [chemical binding]; other site
398580007926	Mg2+ binding site [ion binding]; other site
398580007927	G-X-G motif; other site
398580007928	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
398580007929	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
398580007930	active site
398580007931	phosphorylation site [posttranslational modification]
398580007932	intermolecular recognition site; other site
398580007933	dimerization interface [polypeptide binding]; other site
398580007934	Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822
398580007935	active site
398580007936	catalytic triad [active]
398580007937	oxyanion hole [active]
398580007938	switch loop; other site
398580007939	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181
398580007940	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
398580007941	Walker A/P-loop; other site
398580007942	ATP binding site [chemical binding]; other site
398580007943	Q-loop/lid; other site
398580007944	ABC transporter signature motif; other site
398580007945	Walker B; other site
398580007946	D-loop; other site
398580007947	H-loop/switch region; other site
398580007948	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127
398580007949	FtsX-like permease family; Region: FtsX; pfam02687
398580007950	glycine dehydrogenase; Provisional; Region: PRK05367
398580007951	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
398580007952	tetramer interface [polypeptide binding]; other site
398580007953	pyridoxal 5'-phosphate binding site [chemical binding]; other site
398580007954	catalytic residue [active]
398580007955	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
398580007956	tetramer interface [polypeptide binding]; other site
398580007957	pyridoxal 5'-phosphate binding site [chemical binding]; other site
398580007958	catalytic residue [active]
398580007959	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
398580007960	lipoyl attachment site [posttranslational modification]; other site
398580007961	glycine cleavage system aminomethyltransferase T; Provisional; Region: gcvT; PRK13579
398580007962	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
398580007963	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
398580007964	active site
398580007965	catalytic residues [active]
398580007966	HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822
398580007967	active site
398580007968	homotetramer interface [polypeptide binding]; other site
398580007969	glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534
398580007970	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
398580007971	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
398580007972	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
398580007973	Ligand Binding Site [chemical binding]; other site
398580007974	Plastocyanin [Energy production and conversion]; Region: PetE; COG3794
398580007975	Cupredoxin-like domain; Region: Cupredoxin_1; cl17234
398580007976	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
398580007977	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
398580007978	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
398580007979	hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413
398580007980	Protein of unknown function (DUF1194); Region: DUF1194; pfam06707
398580007981	Protein of unknown function, DUF606; Region: DUF606; pfam04657
398580007982	Cytochrome c; Region: Cytochrom_C; cl11414
398580007983	Cytochrome c; Region: Cytochrom_C; pfam00034
398580007984	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
398580007985	Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355
398580007986	putative ligand binding site [chemical binding]; other site
398580007987	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
398580007988	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
398580007989	TM-ABC transporter signature motif; other site
398580007990	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
398580007991	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
398580007992	TM-ABC transporter signature motif; other site
398580007993	urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411
398580007994	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
398580007995	Walker A/P-loop; other site
398580007996	ATP binding site [chemical binding]; other site
398580007997	Q-loop/lid; other site
398580007998	ABC transporter signature motif; other site
398580007999	Walker B; other site
398580008000	D-loop; other site
398580008001	H-loop/switch region; other site
398580008002	urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410
398580008003	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
398580008004	Walker A/P-loop; other site
398580008005	ATP binding site [chemical binding]; other site
398580008006	Q-loop/lid; other site
398580008007	ABC transporter signature motif; other site
398580008008	Walker B; other site
398580008009	D-loop; other site
398580008010	H-loop/switch region; other site
398580008011	2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428
398580008012	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
398580008013	motif II; other site
398580008014	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
398580008015	Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171
398580008016	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
398580008017	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
398580008018	catalytic residue [active]
398580008019	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
398580008020	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494
398580008021	domain interfaces; other site
398580008022	active site
398580008023	methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252
398580008024	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
398580008025	substrate binding site [chemical binding]; other site
398580008026	active site
398580008027	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
398580008028	putative substrate translocation pore; other site
398580008029	methionyl-tRNA synthetase; Reviewed; Region: PRK12268
398580008030	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
398580008031	active site
398580008032	HIGH motif; other site
398580008033	KMSKS motif; other site
398580008034	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
398580008035	tRNA binding surface [nucleotide binding]; other site
398580008036	anticodon binding site; other site
398580008037	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
398580008038	PAS domain; Region: PAS_9; pfam13426
398580008039	putative active site [active]
398580008040	heme pocket [chemical binding]; other site
398580008041	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
398580008042	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
398580008043	dimer interface [polypeptide binding]; other site
398580008044	phosphorylation site [posttranslational modification]
398580008045	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
398580008046	ATP binding site [chemical binding]; other site
398580008047	Mg2+ binding site [ion binding]; other site
398580008048	G-X-G motif; other site
398580008049	Response regulator receiver domain; Region: Response_reg; pfam00072
398580008050	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
398580008051	active site
398580008052	phosphorylation site [posttranslational modification]
398580008053	intermolecular recognition site; other site
398580008054	dimerization interface [polypeptide binding]; other site
398580008055	methionine sulfoxide reductase B; Provisional; Region: PRK00222
398580008056	SelR domain; Region: SelR; pfam01641
398580008057	Predicted flavoproteins [General function prediction only]; Region: COG2081
398580008058	Cobaltochelatase CobS subunit N terminal; Region: CobS_N; pfam12556
398580008059	cobaltochelatase, CobS subunit; Region: PD_CobS; TIGR01650
398580008060	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
398580008061	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
398580008062	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
398580008063	S-adenosylmethionine binding site [chemical binding]; other site
398580008064	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
398580008065	CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473
398580008066	phosphatidylserine decarboxylase; Provisional; Region: PRK05305
398580008067	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
398580008068	DEAD-like helicases superfamily; Region: DEXDc; smart00487
398580008069	ATP binding site [chemical binding]; other site
398580008070	Mg++ binding site [ion binding]; other site
398580008071	motif III; other site
398580008072	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
398580008073	nucleotide binding region [chemical binding]; other site
398580008074	ATP-binding site [chemical binding]; other site
398580008075	Protein of unknown function (DUF2975); Region: DUF2975; pfam11188
398580008076	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
398580008077	non-specific DNA binding site [nucleotide binding]; other site
398580008078	salt bridge; other site
398580008079	sequence-specific DNA binding site [nucleotide binding]; other site
398580008080	Cobalamin biosynthesis protein CobT; Region: CobT; pfam06213
398580008081	norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role  in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454
398580008082	metal ion-dependent adhesion site (MIDAS); other site
398580008083	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
398580008084	putative catalytic site [active]
398580008085	putative metal binding site [ion binding]; other site
398580008086	putative phosphate binding site [ion binding]; other site
398580008087	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
398580008088	putative metal binding site [ion binding]; other site
398580008089	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
398580008090	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
398580008091	X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085
398580008092	active site
398580008093	Domain of unknown function (DUF427); Region: DUF427; pfam04248
398580008094	Intracellular septation protein A; Region: IspA; pfam04279
398580008095	phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340
398580008096	Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910
398580008097	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
398580008098	signal recognition particle-docking protein FtsY; Region: ftsY; TIGR00064
398580008099	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
398580008100	P loop; other site
398580008101	GTP binding site [chemical binding]; other site
398580008102	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
398580008103	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
398580008104	generic binding surface I; other site
398580008105	generic binding surface II; other site
398580008106	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
398580008107	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
398580008108	ATP-grasp domain; Region: ATP-grasp_4; cl17255
398580008109	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
398580008110	Family description; Region: VCBS; pfam13517
398580008111	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
398580008112	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
398580008113	catalytic loop [active]
398580008114	iron binding site [ion binding]; other site
398580008115	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
398580008116	generic binding surface II; other site
398580008117	generic binding surface I; other site
398580008118	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
398580008119	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
398580008120	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
398580008121	protein binding site [polypeptide binding]; other site
398580008122	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
398580008123	protein binding site [polypeptide binding]; other site
398580008124	Uncharacterized protein conserved in bacteria (DUF2065); Region: DUF2065; pfam09838
398580008125	HflC protein; Region: hflC; TIGR01932
398580008126	Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405
398580008127	Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404
398580008128	HflK protein; Region: hflK; TIGR01933
398580008129	glutathione reductase; Validated; Region: PRK06116
398580008130	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
398580008131	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
398580008132	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
398580008133	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
398580008134	tetramer (dimer of dimers) interface [polypeptide binding]; other site
398580008135	active site
398580008136	dimer interface [polypeptide binding]; other site
398580008137	Thiamine pyrophosphokinase; Region: TPK; cd07995
398580008138	active site
398580008139	thiamine binding site [chemical binding]; other site
398580008140	dimerization interface [polypeptide binding]; other site
398580008141	Protein of unknown function (DUF2842); Region: DUF2842; pfam11003
398580008142	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
398580008143	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
398580008144	GDP-binding site [chemical binding]; other site
398580008145	ACT binding site; other site
398580008146	IMP binding site; other site
398580008147	Preprotein translocase SecG subunit; Region: SecG; pfam03840
398580008148	CTP synthetase; Validated; Region: pyrG; PRK05380
398580008149	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
398580008150	Catalytic site [active]
398580008151	active site
398580008152	UTP binding site [chemical binding]; other site
398580008153	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
398580008154	active site
398580008155	putative oxyanion hole; other site
398580008156	catalytic triad [active]
398580008157	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
398580008158	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
398580008159	putative active site pocket [active]
398580008160	dimerization interface [polypeptide binding]; other site
398580008161	putative catalytic residue [active]
398580008162	glutamyl-tRNA synthetase; Provisional; Region: PRK12558
398580008163	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
398580008164	active site
398580008165	HIGH motif; other site
398580008166	nucleotide binding site [chemical binding]; other site
398580008167	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
398580008168	active site
398580008169	KMSKS motif; other site
398580008170	Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150
398580008171	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
398580008172	DctM-like transporters; Region: DctM; pfam06808
398580008173	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
398580008174	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181
398580008175	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
398580008176	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
398580008177	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
398580008178	active site
398580008179	catalytic tetrad [active]
398580008180	alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565
398580008181	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
398580008182	active site
398580008183	dimer interface [polypeptide binding]; other site
398580008184	non-prolyl cis peptide bond; other site
398580008185	insertion regions; other site
398580008186	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
398580008187	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
398580008188	DNA-binding site [nucleotide binding]; DNA binding site
398580008189	UTRA domain; Region: UTRA; pfam07702
398580008190	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
398580008191	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
398580008192	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
398580008193	phosphoglycolate phosphatase; Provisional; Region: PRK13222
398580008194	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
398580008195	motif II; other site
398580008196	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
398580008197	transmembrane helices; other site
398580008198	TrkA-C domain; Region: TrkA_C; pfam02080
398580008199	TrkA-C domain; Region: TrkA_C; pfam02080
398580008200	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
398580008201	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
398580008202	hypothetical protein; Validated; Region: PRK00110
398580008203	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
398580008204	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
398580008205	transmembrane helices; other site
398580008206	TrkA-C domain; Region: TrkA_C; pfam02080
398580008207	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
398580008208	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
398580008209	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
398580008210	EamA-like transporter family; Region: EamA; cl17759
398580008211	Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382
398580008212	Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854
398580008213	putative active site [active]
398580008214	metal binding site [ion binding]; metal-binding site
398580008215	homodimer binding site [polypeptide binding]; other site
398580008216	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
398580008217	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
398580008218	MgtE intracellular N domain; Region: MgtE_N; smart00924
398580008219	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
398580008220	Divalent cation transporter; Region: MgtE; pfam01769
398580008221	guanine deaminase; Provisional; Region: PRK09228
398580008222	Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303
398580008223	active site
398580008224	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
398580008225	hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203
398580008226	TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298
398580008227	active site
398580008228	putative substrate binding pocket [chemical binding]; other site
398580008229	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
398580008230	Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate,  or similar substrates; Region: Bacterial_IMPase_like_1; cd01641
398580008231	active site
398580008232	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
398580008233	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
398580008234	non-specific DNA binding site [nucleotide binding]; other site
398580008235	salt bridge; other site
398580008236	sequence-specific DNA binding site [nucleotide binding]; other site
398580008237	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
398580008238	Quinone oxidoreductase (QOR); Region: QOR1; cd08241
398580008239	NAD(P) binding site [chemical binding]; other site
398580008240	Transcriptional regulator [Transcription]; Region: LysR; COG0583
398580008241	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
398580008242	LysR substrate binding domain; Region: LysR_substrate; pfam03466
398580008243	dimerization interface [polypeptide binding]; other site
398580008244	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
398580008245	Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432
398580008246	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
398580008247	PAS fold; Region: PAS_4; pfam08448
398580008248	N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023
398580008249	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
398580008250	amidase catalytic site [active]
398580008251	Zn binding residues [ion binding]; other site
398580008252	substrate binding site [chemical binding]; other site
398580008253	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
398580008254	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
398580008255	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
398580008256	Poxvirus P21 membrane protein; Region: Pox_P21; pfam05313
398580008257	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
398580008258	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
398580008259	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
398580008260	nucleoside/Zn binding site; other site
398580008261	dimer interface [polypeptide binding]; other site
398580008262	catalytic motif [active]
398580008263	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
398580008264	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
398580008265	RNA binding surface [nucleotide binding]; other site
398580008266	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
398580008267	active site
398580008268	Toxic anion resistance protein (TelA); Region: TelA; pfam05816
398580008269	Protein of unknown function (DUF2927); Region: DUF2927; pfam11150
398580008270	A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual...; Region: Band_7_5; cd03408
398580008271	Domain of unknown function (DUF4339); Region: DUF4339; pfam14237
398580008272	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
398580008273	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
398580008274	putative dimer interface [polypeptide binding]; other site
398580008275	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
398580008276	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
398580008277	putative substrate binding site [chemical binding]; other site
398580008278	putative ATP binding site [chemical binding]; other site
398580008279	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
398580008280	putative active site [active]
398580008281	dimerization interface [polypeptide binding]; other site
398580008282	putative tRNAtyr binding site [nucleotide binding]; other site
398580008283	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
398580008284	Flavocytochrome c sulphide dehydrogenase, flavin-binding; Region: FCSD-flav_bind; pfam09242
398580008285	Cytochrome c2 [Energy production and conversion]; Region: COG3474
398580008286	putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603
398580008287	Cytochrome c; Region: Cytochrom_C; cl11414
398580008288	Cytochrome c; Region: Cytochrom_C; pfam00034
398580008289	Cytochrome c2 [Energy production and conversion]; Region: COG3474
398580008290	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
398580008291	Moco binding site; other site
398580008292	metal coordination site [ion binding]; other site
398580008293	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
398580008294	Thermus thermophilus SoxB and related proteins, N-terminal metallophosphatase domain; Region: MPP_SoxB_N; cd07411
398580008295	active site
398580008296	metal binding site [ion binding]; metal-binding site
398580008297	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
398580008298	Cytochrome c [Energy production and conversion]; Region: COG3258
398580008299	Sulphur oxidation protein SoxZ; Region: SoxZ; pfam08770
398580008300	sulfur oxidation protein SoxY; Provisional; Region: PRK07474
398580008301	Sulfur oxidation protein SoxY; Region: SoxY; pfam13501
398580008302	Cytochrome c; Region: Cytochrom_C; pfam00034
398580008303	SoxW family; SoxW is a bacterial periplasmic TRX, containing a redox active CXXC motif, encoded by a genetic locus (sox operon) involved in thiosulfate oxidation. Sulfur bacteria oxidize sulfur compounds to provide reducing equivalents for carbon dioxide...; Region: SoxW; cd02951
398580008304	catalytic residues [active]
398580008305	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
398580008306	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683
398580008307	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
398580008308	Domain of unknown function (DUF336); Region: DUF336; cl01249
398580008309	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
398580008310	dimerization interface [polypeptide binding]; other site
398580008311	putative DNA binding site [nucleotide binding]; other site
398580008312	putative Zn2+ binding site [ion binding]; other site
398580008313	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
398580008314	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
398580008315	metal binding site [ion binding]; metal-binding site
398580008316	active site
398580008317	I-site; other site
398580008318	Heme NO binding; Region: HNOB; pfam07700
398580008319	Domain of unknown function (DUF4153); Region: DUF4153; pfam13687
398580008320	Trimethylamine methyltransferase (MTTB); Region: MTTB; cl15385
398580008321	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
398580008322	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
398580008323	motif II; other site
398580008324	Protein of unknown function (DUF3572); Region: DUF3572; pfam12096
398580008325	response regulator PleD; Reviewed; Region: pleD; PRK09581
398580008326	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
398580008327	active site
398580008328	phosphorylation site [posttranslational modification]
398580008329	intermolecular recognition site; other site
398580008330	dimerization interface [polypeptide binding]; other site
398580008331	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
398580008332	metal binding site [ion binding]; metal-binding site
398580008333	active site
398580008334	I-site; other site
398580008335	Protein of unknown function (DUF983); Region: DUF983; pfam06170
398580008336	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
398580008337	nudix motif; other site
398580008338	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
398580008339	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
398580008340	active site
398580008341	catalytic tetrad [active]
398580008342	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
398580008343	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
398580008344	active site
398580008345	Uncharacterized conserved protein [Function unknown]; Region: COG4544
398580008346	YceI-like domain; Region: YceI; pfam04264
398580008347	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
398580008348	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
398580008349	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
398580008350	Walker A motif; other site
398580008351	ATP binding site [chemical binding]; other site
398580008352	Walker B motif; other site
398580008353	arginine finger; other site
398580008354	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
398580008355	glutathione synthetase; Provisional; Region: PRK05246
398580008356	Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951
398580008357	Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955
398580008358	Uncharacterized protein family UPF0102; Region: UPF0102; cl00516
398580008359	Predicted methyltransferases [General function prediction only]; Region: COG0313
398580008360	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
398580008361	putative SAM binding site [chemical binding]; other site
398580008362	putative homodimer interface [polypeptide binding]; other site
398580008363	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
398580008364	Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339
398580008365	putative ligand binding site [chemical binding]; other site
398580008366	PII uridylyl-transferase; Provisional; Region: PRK05092
398580008367	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
398580008368	metal binding triad; other site
398580008369	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
398580008370	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
398580008371	Zn2+ binding site [ion binding]; other site
398580008372	Mg2+ binding site [ion binding]; other site
398580008373	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
398580008374	C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899
398580008375	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
398580008376	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
398580008377	Rhomboid family; Region: Rhomboid; pfam01694
398580008378	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
398580008379	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
398580008380	active site
398580008381	HIGH motif; other site
398580008382	dimer interface [polypeptide binding]; other site
398580008383	KMSKS motif; other site
398580008384	aminotransferase; Provisional; Region: PRK13356
398580008385	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
398580008386	homodimer interface [polypeptide binding]; other site
398580008387	substrate-cofactor binding pocket; other site
398580008388	pyridoxal 5'-phosphate binding site [chemical binding]; other site
398580008389	catalytic residue [active]
398580008390	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
398580008391	Ligand Binding Site [chemical binding]; other site
398580008392	Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; pfam08712
398580008393	Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694
398580008394	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
398580008395	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
398580008396	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
398580008397	Coenzyme A binding pocket [chemical binding]; other site
398580008398	Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354
398580008399	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
398580008400	ligand binding site [chemical binding]; other site
398580008401	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
398580008402	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
398580008403	Walker A/P-loop; other site
398580008404	ATP binding site [chemical binding]; other site
398580008405	Q-loop/lid; other site
398580008406	ABC transporter signature motif; other site
398580008407	Walker B; other site
398580008408	D-loop; other site
398580008409	H-loop/switch region; other site
398580008410	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
398580008411	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
398580008412	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
398580008413	TM-ABC transporter signature motif; other site
398580008414	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
398580008415	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
398580008416	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
398580008417	TM-ABC transporter signature motif; other site
398580008418	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
398580008419	hypothetical protein; Provisional; Region: PRK10621
398580008420	Putative transmembrane protein (Alph_Pro_TM); Region: Alph_Pro_TM; pfam09608
398580008421	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
398580008422	classical (c) SDRs; Region: SDR_c; cd05233
398580008423	NAD(P) binding site [chemical binding]; other site
398580008424	active site
398580008425	AAA domain; Region: AAA_30; pfam13604
398580008426	Family description; Region: UvrD_C_2; pfam13538
398580008427	Autoinducer synthetase; Region: Autoind_synth; cl17404
398580008428	Autoinducer binding domain; Region: Autoind_bind; pfam03472
398580008429	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
398580008430	DNA binding residues [nucleotide binding]
398580008431	dimerization interface [polypeptide binding]; other site
398580008432	crotonyl-CoA reductase; Region: crotonyl_coA_red; cd08246
398580008433	crotonyl-CoA reductase; Region: crot-CoA-red; TIGR01751
398580008434	putative NAD(P) binding site [chemical binding]; other site
398580008435	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185
398580008436	putative acyl-acceptor binding pocket; other site
398580008437	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817
398580008438	methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071
398580008439	B12 binding site [chemical binding]; other site
398580008440	cobalt ligand [ion binding]; other site
398580008441	Domain of unknown function (DUF4329); Region: DUF4329; pfam14220
398580008442	purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819
398580008443	Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820
398580008444	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950
398580008445	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
398580008446	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230
398580008447	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK09078
398580008448	L-aspartate oxidase; Provisional; Region: PRK06175
398580008449	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
398580008450	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit-like; composed of predominantly uncharacterized bacterial proteins with similarity to the E. coli SdhD subunit. One characterized protein is the respiratory...; Region: SQR_TypeC_SdhD_like; cd03495
398580008451	putative SdhC subunit interface [polypeptide binding]; other site
398580008452	putative proximal heme binding site [chemical binding]; other site
398580008453	putative Iron-sulfur protein interface [polypeptide binding]; other site
398580008454	putative proximal quinone binding site; other site
398580008455	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499
398580008456	Iron-sulfur protein interface; other site
398580008457	proximal quinone binding site [chemical binding]; other site
398580008458	SdhD (CybS) interface [polypeptide binding]; other site
398580008459	proximal heme binding site [chemical binding]; other site
398580008460	Cytochrome C' Region: Cytochrom_C_2; pfam01322
398580008461	Cytochrome c; Region: Cytochrom_C; pfam00034
398580008462	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
398580008463	CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cl11964
398580008464	Cytochrome c; Region: Cytochrom_C; pfam00034
398580008465	FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2  has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451
398580008466	putative active site [active]
398580008467	putative catalytic site [active]
398580008468	FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2  has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451
398580008469	putative active site [active]
398580008470	putative catalytic site [active]
398580008471	Uncharacterized conserved small protein [Function unknown]; Region: COG5515
398580008472	NnrU protein; Region: NnrU; pfam07298
398580008473	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
398580008474	malate dehydrogenase; Reviewed; Region: PRK06223
398580008475	L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339
398580008476	NAD(P) binding site [chemical binding]; other site
398580008477	dimer interface [polypeptide binding]; other site
398580008478	tetramer (dimer of dimers) interface [polypeptide binding]; other site
398580008479	substrate binding site [chemical binding]; other site
398580008480	Glycosyl transferase family 2; Region: Glyco_tranf_2_4; pfam13704
398580008481	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
398580008482	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
398580008483	CoA-ligase; Region: Ligase_CoA; pfam00549
398580008484	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
398580008485	CoA binding domain; Region: CoA_binding; pfam02629
398580008486	CoA-ligase; Region: Ligase_CoA; pfam00549
398580008487	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
398580008488	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
398580008489	TPP-binding site [chemical binding]; other site
398580008490	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
398580008491	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
398580008492	E3 interaction surface; other site
398580008493	lipoyl attachment site [posttranslational modification]; other site
398580008494	dihydrolipoamide succinyltransferase; Validated; Region: PRK05704
398580008495	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
398580008496	E3 interaction surface; other site
398580008497	lipoyl attachment site [posttranslational modification]; other site
398580008498	e3 binding domain; Region: E3_binding; pfam02817
398580008499	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
398580008500	MAPEG family; Region: MAPEG; pfam01124
398580008501	dihydrolipoamide dehydrogenase; Validated; Region: PRK06327
398580008502	Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730
398580008503	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
398580008504	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
398580008505	succinic semialdehyde dehydrogenase; Region: PLN02278
398580008506	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
398580008507	tetramerization interface [polypeptide binding]; other site
398580008508	NAD(P) binding site [chemical binding]; other site
398580008509	catalytic residues [active]
398580008510	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
398580008511	Protein of unknown function (DUF2974); Region: DUF2974; pfam11187
398580008512	nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252
398580008513	putative active site pocket [active]
398580008514	cleavage site
398580008515	putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR), subgroup 3, classical (c) SDR; Region: BKR_3_SDR_c; cd05345
398580008516	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
398580008517	putative NAD(P) binding site [chemical binding]; other site
398580008518	active site
398580008519	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
398580008520	Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins.  IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470
398580008521	putative dimer interface [polypeptide binding]; other site
398580008522	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
398580008523	active site
398580008524	glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274
398580008525	Cysteine-rich domain; Region: CCG; pfam02754
398580008526	Cysteine-rich domain; Region: CCG; pfam02754
398580008527	FAD binding domain; Region: FAD_binding_4; pfam01565
398580008528	glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282
398580008529	glycolate oxidase subunit GlcD; Provisional; Region: PRK11230
398580008530	FAD binding domain; Region: FAD_binding_4; pfam01565
398580008531	PUCC protein; Region: PUCC; pfam03209
398580008532	Antenna complex alpha/beta subunit; Region: LHC; pfam00556
398580008533	Antenna complex alpha/beta subunit; Region: LHC; pfam00556
398580008534	Esterase-like activity of phytase; Region: Phytase-like; pfam13449
398580008535	Protein of unknown function (DUF1355); Region: DUF1355; cl17712
398580008536	Protein of unknown function (DUF1355); Region: DUF1355; cl17712
398580008537	Filamin-type immunoglobulin domains; Region: IG_FLMN; smart00557
398580008538	A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143
398580008539	Domain of unknown function (DUF4159); Region: DUF4159; pfam13709
398580008540	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
398580008541	Protein of unknown function DUF58; Region: DUF58; pfam01882
398580008542	MoxR-like ATPases [General function prediction only]; Region: COG0714
398580008543	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
398580008544	Walker A motif; other site
398580008545	ATP binding site [chemical binding]; other site
398580008546	Walker B motif; other site
398580008547	arginine finger; other site
398580008548	Protein of unknown function (DUF1285); Region: DUF1285; pfam06938
398580008549	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
398580008550	pseudouridine synthase; Region: TIGR00093
398580008551	active site
398580008552	DNA polymerase I; Provisional; Region: PRK05755
398580008553	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
398580008554	active site
398580008555	metal binding site 1 [ion binding]; metal-binding site
398580008556	putative 5' ssDNA interaction site; other site
398580008557	metal binding site 3; metal-binding site
398580008558	metal binding site 2 [ion binding]; metal-binding site
398580008559	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
398580008560	putative DNA binding site [nucleotide binding]; other site
398580008561	putative metal binding site [ion binding]; other site
398580008562	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
398580008563	active site
398580008564	catalytic site [active]
398580008565	substrate binding site [chemical binding]; other site
398580008566	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
398580008567	active site
398580008568	DNA binding site [nucleotide binding]
398580008569	catalytic site [active]
398580008570	Haemolysin-III related; Region: HlyIII; cl03831
398580008571	Protein of unknown function (DUF2459); Region: DUF2459; pfam09601
398580008572	Zinc-finger domain; Region: zf-CHCC; pfam10276
398580008573	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
398580008574	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
398580008575	Walker A/P-loop; other site
398580008576	ATP binding site [chemical binding]; other site
398580008577	Q-loop/lid; other site
398580008578	ABC transporter signature motif; other site
398580008579	Walker B; other site
398580008580	D-loop; other site
398580008581	H-loop/switch region; other site
398580008582	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
398580008583	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
398580008584	nudix motif; other site
398580008585	phosphonate metabolism protein PhnM; Provisional; Region: PRK15446
398580008586	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
398580008587	active site
398580008588	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
398580008589	Coenzyme A binding pocket [chemical binding]; other site
398580008590	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
398580008591	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
398580008592	ring oligomerisation interface [polypeptide binding]; other site
398580008593	ATP/Mg binding site [chemical binding]; other site
398580008594	stacking interactions; other site
398580008595	hinge regions; other site
398580008596	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
398580008597	oligomerisation interface [polypeptide binding]; other site
398580008598	mobile loop; other site
398580008599	roof hairpin; other site
398580008600	Uncharacterized conserved protein (DUF2161); Region: DUF2161; cl02298
398580008601	5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694
398580008602	putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427
398580008603	DHH family; Region: DHH; pfam01368
398580008604	DHHA2 domain; Region: DHHA2; pfam02833
398580008605	HAD-superfamily class IIA hydrolase, TIGR01459; Region: HAD-SF-IIA-hyp4
398580008606	Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344
398580008607	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
398580008608	(R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449
398580008609	dimer interaction site [polypeptide binding]; other site
398580008610	substrate-binding tunnel; other site
398580008611	active site
398580008612	catalytic site [active]
398580008613	substrate binding site [chemical binding]; other site
398580008614	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
398580008615	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
398580008616	active site
398580008617	Riboflavin kinase; Region: Flavokinase; pfam01687
398580008618	hypothetical protein; Provisional; Region: PRK05170
398580008619	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
398580008620	2-hydroxychromene-2-carboxylate isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NahD; COG3917
398580008621	DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022
398580008622	putative catalytic residue [active]
398580008623	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
398580008624	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
398580008625	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
398580008626	active site
398580008627	H-type lectin domain; Region: H_lectin; pfam09458
398580008628	F0F1 ATP synthase subunit epsilon; Provisional; Region: atpC; PRK13443
398580008629	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
398580008630	gamma subunit interface [polypeptide binding]; other site
398580008631	LBP interface [polypeptide binding]; other site
398580008632	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
398580008633	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
398580008634	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
398580008635	alpha subunit interaction interface [polypeptide binding]; other site
398580008636	Walker A motif; other site
398580008637	ATP binding site [chemical binding]; other site
398580008638	Walker B motif; other site
398580008639	inhibitor binding site; inhibition site
398580008640	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
398580008641	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
398580008642	core domain interface [polypeptide binding]; other site
398580008643	delta subunit interface [polypeptide binding]; other site
398580008644	epsilon subunit interface [polypeptide binding]; other site
398580008645	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
398580008646	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
398580008647	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
398580008648	beta subunit interaction interface [polypeptide binding]; other site
398580008649	Walker A motif; other site
398580008650	ATP binding site [chemical binding]; other site
398580008651	Walker B motif; other site
398580008652	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
398580008653	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
398580008654	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
398580008655	Methyltransferase domain; Region: Methyltransf_23; pfam13489
398580008656	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
398580008657	ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639
398580008658	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
398580008659	Walker A motif; other site
398580008660	ATP binding site [chemical binding]; other site
398580008661	Walker B motif; other site
398580008662	arginine finger; other site
398580008663	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
398580008664	Walker A motif; other site
398580008665	ATP binding site [chemical binding]; other site
398580008666	Walker B motif; other site
398580008667	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
398580008668	hypothetical protein; Validated; Region: PRK09039
398580008669	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
398580008670	ligand binding site [chemical binding]; other site
398580008671	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
398580008672	putative active site pocket [active]
398580008673	dimerization interface [polypeptide binding]; other site
398580008674	putative catalytic residue [active]
398580008675	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4093
398580008676	Uncharacterized protein conserved in bacteria (DUF2125); Region: DUF2125; pfam09898
398580008677	Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904
398580008678	cyclohexadienyl dehydrogenase; Validated; Region: PRK07502
398580008679	prephenate dehydrogenase; Validated; Region: PRK08507
398580008680	histidinol-phosphate aminotransferase; Validated; Region: PRK02731
398580008681	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
398580008682	pyridoxal 5'-phosphate binding site [chemical binding]; other site
398580008683	homodimer interface [polypeptide binding]; other site
398580008684	catalytic residue [active]
398580008685	Homospermidine synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG5310
398580008686	Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435
398580008687	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
398580008688	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
398580008689	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
398580008690	RNA binding surface [nucleotide binding]; other site
398580008691	Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317
398580008692	ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Region: NrdJ_Z; TIGR02504
398580008693	Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888
398580008694	active site
398580008695	dimer interface [polypeptide binding]; other site
398580008696	effector binding site; other site
398580008697	TSCPD domain; Region: TSCPD; pfam12637
398580008698	Protein of unknown function (DUF1489); Region: DUF1489; pfam07370
398580008699	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
398580008700	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
398580008701	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
398580008702	catalytic residue [active]
398580008703	pantoate--beta-alanine ligase; Region: panC; TIGR00018
398580008704	Pantoate-beta-alanine ligase; Region: PanC; cd00560
398580008705	active site
398580008706	ATP-binding site [chemical binding]; other site
398580008707	pantoate-binding site; other site
398580008708	HXXH motif; other site
398580008709	ATP phosphoribosyltransferase catalytic subunit; Provisional; Region: hisG; PRK13583
398580008710	ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489
398580008711	ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12295
398580008712	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
398580008713	dimer interface [polypeptide binding]; other site
398580008714	motif 1; other site
398580008715	active site
398580008716	motif 2; other site
398580008717	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
398580008718	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
398580008719	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
398580008720	dimer interface [polypeptide binding]; other site
398580008721	motif 1; other site
398580008722	motif 2; other site
398580008723	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
398580008724	active site
398580008725	motif 3; other site
398580008726	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
398580008727	anticodon binding site; other site
398580008728	SlyX; Region: SlyX; pfam04102
398580008729	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
398580008730	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433
398580008731	putative active site [active]
398580008732	putative PHP Thumb interface [polypeptide binding]; other site
398580008733	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
398580008734	generic binding surface II; other site
398580008735	generic binding surface I; other site
398580008736	xanthine dehydrogenase, small subunit; Region: xanthine_xdhA; TIGR02963
398580008737	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
398580008738	catalytic loop [active]
398580008739	iron binding site [ion binding]; other site
398580008740	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
398580008741	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450
398580008742	xanthine dehydrogenase, molybdopterin binding subunit; Region: xanthine_xdhB; TIGR02965
398580008743	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
398580008744	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
398580008745	xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964
398580008746	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
398580008747	XdhC Rossmann domain; Region: XdhC_C; pfam13478
398580008748	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
398580008749	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
398580008750	Walker A/P-loop; other site
398580008751	ATP binding site [chemical binding]; other site
398580008752	Q-loop/lid; other site
398580008753	ABC transporter signature motif; other site
398580008754	Walker B; other site
398580008755	D-loop; other site
398580008756	H-loop/switch region; other site
398580008757	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
398580008758	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
398580008759	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
398580008760	TM-ABC transporter signature motif; other site
398580008761	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
398580008762	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
398580008763	TM-ABC transporter signature motif; other site
398580008764	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
398580008765	Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353
398580008766	putative ligand binding site [chemical binding]; other site
398580008767	Protein of unknown function (DUF2892); Region: DUF2892; pfam11127
398580008768	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
398580008769	oligomerization interface [polypeptide binding]; other site
398580008770	active site
398580008771	metal binding site [ion binding]; metal-binding site
398580008772	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
398580008773	hydroxyglutarate oxidase; Provisional; Region: PRK11728
398580008774	Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404
398580008775	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
398580008776	Hint domain; Region: Hint_2; pfam13403
398580008777	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
398580008778	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
398580008779	D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301
398580008780	dimerization interface [polypeptide binding]; other site
398580008781	ligand binding site [chemical binding]; other site
398580008782	NADP binding site [chemical binding]; other site
398580008783	catalytic site [active]
398580008784	Bacterial SH3 domain; Region: SH3_4; pfam06347
398580008785	Bacterial SH3 domain; Region: SH3_4; pfam06347
398580008786	PAS fold; Region: PAS; pfam00989
398580008787	PAS domain; Region: PAS; smart00091
398580008788	putative active site [active]
398580008789	heme pocket [chemical binding]; other site
398580008790	Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339
398580008791	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
398580008792	active site
398580008793	Zn binding site [ion binding]; other site
398580008794	molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690
398580008795	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
398580008796	ATP binding site [chemical binding]; other site
398580008797	substrate interface [chemical binding]; other site
398580008798	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
398580008799	trimer interface [polypeptide binding]; other site
398580008800	active site
398580008801	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
398580008802	Flavoprotein; Region: Flavoprotein; pfam02441
398580008803	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
398580008804	Protein of unknown function, DUF399; Region: DUF399; pfam04187
398580008805	RNA polymerase factor sigma-32; Reviewed; Region: rpoH2; PRK07500
398580008806	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
398580008807	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
398580008808	DNA binding residues [nucleotide binding]
398580008809	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
398580008810	homotrimer interface [polypeptide binding]; other site
398580008811	Walker A motif; other site
398580008812	GTP binding site [chemical binding]; other site
398580008813	Walker B motif; other site
398580008814	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399
398580008815	sulfite oxidase; Provisional; Region: PLN00177
398580008816	Subgroup of sulfite oxidase (SO) family molybdopterin binding domains that contains conserved dimerization domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate...; Region: SO_family_Moco_dimer; cd02110
398580008817	Moco binding site; other site
398580008818	metal coordination site [ion binding]; other site
398580008819	dimerization interface [polypeptide binding]; other site
398580008820	quinohemoprotein amine dehydrogenase, alpha subunit; Region: QH_alpha; TIGR03908
398580008821	Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130
398580008822	Prostaglandin dehydrogenases; Region: PGDH; cd05288
398580008823	NAD(P) binding site [chemical binding]; other site
398580008824	substrate binding site [chemical binding]; other site
398580008825	dimer interface [polypeptide binding]; other site
398580008826	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
398580008827	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
398580008828	C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194
398580008829	putative N-terminal domain interface [polypeptide binding]; other site
398580008830	putative dimer interface [polypeptide binding]; other site
398580008831	putative substrate binding pocket (H-site) [chemical binding]; other site
398580008832	Transcriptional regulators [Transcription]; Region: FadR; COG2186
398580008833	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
398580008834	DNA-binding site [nucleotide binding]; DNA binding site
398580008835	FCD domain; Region: FCD; pfam07729
398580008836	Protein of unknown function DUF45; Region: DUF45; pfam01863
398580008837	Protein of unknown function (FYDLN_acid); Region: FYDLN_acid; pfam09538
398580008838	TIGR02300 family protein; Region: FYDLN_acid
398580008839	Putative heavy-metal-binding; Region: YbjQ_1; cl00426
398580008840	Transcriptional regulator [Transcription]; Region: LysR; COG0583
398580008841	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
398580008842	LysR substrate binding domain; Region: LysR_substrate; pfam03466
398580008843	dimerization interface [polypeptide binding]; other site
398580008844	Protein of unknown function (DUF1643); Region: DUF1643; pfam07799
398580008845	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
398580008846	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
398580008847	16S/18S rRNA binding site [nucleotide binding]; other site
398580008848	S13e-L30e interaction site [polypeptide binding]; other site
398580008849	25S rRNA binding site [nucleotide binding]; other site
398580008850	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
398580008851	putative catalytic site [active]
398580008852	putative metal binding site [ion binding]; other site
398580008853	putative phosphate binding site [ion binding]; other site
398580008854	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
398580008855	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
398580008856	RNase E interface [polypeptide binding]; other site
398580008857	trimer interface [polypeptide binding]; other site
398580008858	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
398580008859	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
398580008860	RNase E interface [polypeptide binding]; other site
398580008861	trimer interface [polypeptide binding]; other site
398580008862	active site
398580008863	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
398580008864	putative nucleic acid binding region [nucleotide binding]; other site
398580008865	G-X-X-G motif; other site
398580008866	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
398580008867	RNA binding site [nucleotide binding]; other site
398580008868	domain interface; other site
398580008869	putative mechanosensitive channel protein; Provisional; Region: PRK11465
398580008870	Mechanosensitive ion channel; Region: MS_channel; pfam00924
398580008871	malonyl-CoA synthase; Validated; Region: PRK07514
398580008872	Malonyl-CoA synthetase (MCS); Region: MCS; cd05941
398580008873	acyl-activating enzyme (AAE) consensus motif; other site
398580008874	active site
398580008875	AMP binding site [chemical binding]; other site
398580008876	CoA binding site [chemical binding]; other site
398580008877	Malonyl-CoA decarboxylase (MCD); Region: MCD; pfam05292
398580008878	DctM-like transporters; Region: DctM; pfam06808
398580008879	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
398580008880	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
398580008881	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
398580008882	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
398580008883	Transcriptional regulators [Transcription]; Region: GntR; COG1802
398580008884	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
398580008885	DNA-binding site [nucleotide binding]; DNA binding site
398580008886	FCD domain; Region: FCD; pfam07729
398580008887	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
398580008888	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
398580008889	substrate binding site [chemical binding]; other site
398580008890	hexamer interface [polypeptide binding]; other site
398580008891	metal binding site [ion binding]; metal-binding site
398580008892	Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383
398580008893	N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789
398580008894	active site
398580008895	catalytic site [active]
398580008896	Alpha mannosidase, middle domain; Region: Alpha-mann_mid; pfam09261
398580008897	Glycosyl hydrolases family 38 C-terminal domain; Region: Glyco_hydro_38C; pfam07748
398580008898	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
398580008899	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
398580008900	Walker A/P-loop; other site
398580008901	ATP binding site [chemical binding]; other site
398580008902	Q-loop/lid; other site
398580008903	ABC transporter signature motif; other site
398580008904	Walker B; other site
398580008905	D-loop; other site
398580008906	H-loop/switch region; other site
398580008907	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
398580008908	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
398580008909	Walker A/P-loop; other site
398580008910	ATP binding site [chemical binding]; other site
398580008911	Q-loop/lid; other site
398580008912	ABC transporter signature motif; other site
398580008913	Walker B; other site
398580008914	D-loop; other site
398580008915	H-loop/switch region; other site
398580008916	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
398580008917	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
398580008918	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
398580008919	dimer interface [polypeptide binding]; other site
398580008920	conserved gate region; other site
398580008921	putative PBP binding loops; other site
398580008922	ABC-ATPase subunit interface; other site
398580008923	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
398580008924	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
398580008925	dimer interface [polypeptide binding]; other site
398580008926	conserved gate region; other site
398580008927	putative PBP binding loops; other site
398580008928	ABC-ATPase subunit interface; other site
398580008929	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
398580008930	The substrate binding domain of a cellulose-binding protein from Thermotoga maritima contains the type 2 periplasmic binding fold; Region: PBP2_TmCBP_oligosaccharides_like; cd08509
398580008931	substrate binding site [chemical binding]; other site
398580008932	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
398580008933	Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483
398580008934	Protein of unknown function, DUF606; Region: DUF606; pfam04657
398580008935	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721
398580008936	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
398580008937	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
398580008938	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
398580008939	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
398580008940	intersubunit interface [polypeptide binding]; other site
398580008941	active site
398580008942	catalytic residue [active]
398580008943	Aldehyde dehydrogenase family 16A1-like; Region: ALDH_F16; cd07111
398580008944	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
398580008945	NAD(P) binding site [chemical binding]; other site
398580008946	catalytic residues [active]
398580008947	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
398580008948	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
398580008949	NAD(P) binding site [chemical binding]; other site
398580008950	Protein of unknown function (DUF1523); Region: DUF1523; pfam07509
398580008951	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13013
398580008952	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
398580008953	metal binding site [ion binding]; metal-binding site
398580008954	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
398580008955	Uncharacterized Saccharopolyspora spinosa aldehyde dehydrogenase (AAS00426)-like; Region: ALDH_AAS00426; cd07109
398580008956	NAD(P) binding site [chemical binding]; other site
398580008957	catalytic residues [active]
398580008958	catalytic residues [active]
398580008959	Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168
398580008960	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
398580008961	substrate binding site [chemical binding]; other site
398580008962	ATP binding site [chemical binding]; other site
398580008963	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
398580008964	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
398580008965	minor groove reading motif; other site
398580008966	helix-hairpin-helix signature motif; other site
398580008967	substrate binding pocket [chemical binding]; other site
398580008968	active site
398580008969	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
398580008970	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
398580008971	Helix-turn-helix domain; Region: HTH_18; pfam12833
398580008972	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
398580008973	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
398580008974	DNA binding site [nucleotide binding]
398580008975	active site
398580008976	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
398580008977	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
398580008978	ligand binding site [chemical binding]; other site
398580008979	transcriptional regulator PdhR; Reviewed; Region: pdhR; PRK09464
398580008980	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
398580008981	DNA-binding site [nucleotide binding]; DNA binding site
398580008982	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
398580008983	F0F1 ATP synthase subunit B; Provisional; Region: PRK13455
398580008984	F0F1 ATP synthase subunit B'; Provisional; Region: PRK13454
398580008985	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
398580008986	F0F1 ATP synthase subunit C; Validated; Region: PRK07558
398580008987	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
398580008988	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
398580008989	Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; cl09754
398580008990	Heparinase II/III-like protein; Region: Hepar_II_III; cl15421
398580008991	NusB family; Region: NusB; pfam01029
398580008992	tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144
398580008993	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
398580008994	S-adenosylmethionine binding site [chemical binding]; other site
398580008995	Uncharacterized conserved small protein [Function unknown]; Region: COG5508
398580008996	Protein of unknown function (DUF1674); Region: DUF1674; pfam07896
398580008997	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
398580008998	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
398580008999	Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845
398580009000	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
398580009001	E3 interaction surface; other site
398580009002	lipoyl attachment site [posttranslational modification]; other site
398580009003	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
398580009004	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
398580009005	Sensors of blue-light using FAD; Region: BLUF; pfam04940
398580009006	dihydrodipicolinate reductase; Provisional; Region: PRK00048
398580009007	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
398580009008	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
398580009009	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
398580009010	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05389
398580009011	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
398580009012	RNA binding site [nucleotide binding]; other site
398580009013	active site
398580009014	Protein of unknown function (DUF1294); Region: DUF1294; pfam06961
398580009015	Tannase and feruloyl esterase; Region: Tannase; pfam07519
398580009016	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
398580009017	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
398580009018	active site
398580009019	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
398580009020	Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379
398580009021	Domain of unknown function (DUF4147); Region: DUF4147; pfam13660
398580009022	MOFRL family; Region: MOFRL; pfam05161
398580009023	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
398580009024	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
398580009025	Transcriptional regulators [Transcription]; Region: FadR; COG2186
398580009026	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
398580009027	DNA-binding site [nucleotide binding]; DNA binding site
398580009028	FCD domain; Region: FCD; pfam07729
398580009029	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
398580009030	NAD(P) binding site [chemical binding]; other site
398580009031	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
398580009032	active site
398580009033	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
398580009034	Mu-like prophage I protein; Region: Mu-like_Pro; pfam10123
398580009035	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
398580009036	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
398580009037	putative acyl-acceptor binding pocket; other site
398580009038	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
398580009039	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
398580009040	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
398580009041	Walker A/P-loop; other site
398580009042	ATP binding site [chemical binding]; other site
398580009043	Q-loop/lid; other site
398580009044	ABC transporter signature motif; other site
398580009045	Walker B; other site
398580009046	D-loop; other site
398580009047	H-loop/switch region; other site
398580009048	zinc-ribbon domain; Region: zinc_ribbon_5; pfam13719
398580009049	Domain of unknown function (DUF4175); Region: DUF4175; pfam13779
398580009050	diaminopimelate decarboxylase; Region: lysA; TIGR01048
398580009051	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
398580009052	active site
398580009053	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
398580009054	substrate binding site [chemical binding]; other site
398580009055	catalytic residues [active]
398580009056	dimer interface [polypeptide binding]; other site
398580009057	Protein of unknown function (DUF2834); Region: DUF2834; pfam11196
398580009058	argininosuccinate lyase; Provisional; Region: PRK00855
398580009059	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
398580009060	active sites [active]
398580009061	tetramer interface [polypeptide binding]; other site
398580009062	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
398580009063	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
398580009064	catalytic residues [active]
398580009065	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
398580009066	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
398580009067	putative acyltransferase; Provisional; Region: PRK05790
398580009068	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
398580009069	dimer interface [polypeptide binding]; other site
398580009070	active site
398580009071	acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829
398580009072	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
398580009073	NAD(P) binding site [chemical binding]; other site
398580009074	homotetramer interface [polypeptide binding]; other site
398580009075	homodimer interface [polypeptide binding]; other site
398580009076	active site
398580009077	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
398580009078	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
398580009079	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
398580009080	dimerization interface [polypeptide binding]; other site
398580009081	substrate binding pocket [chemical binding]; other site
398580009082	Protein of unknown function (DUF465); Region: DUF465; cl01070
398580009083	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
398580009084	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
398580009085	S-adenosylmethionine binding site [chemical binding]; other site
398580009086	Domain of unknown function (DUF2007); Region: DUF2007; pfam09413
398580009087	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
398580009088	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
398580009089	substrate binding pocket [chemical binding]; other site
398580009090	chain length determination region; other site
398580009091	substrate-Mg2+ binding site; other site
398580009092	catalytic residues [active]
398580009093	aspartate-rich region 1; other site
398580009094	active site lid residues [active]
398580009095	aspartate-rich region 2; other site
398580009096	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14608
398580009097	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
398580009098	binding surface
398580009099	TPR motif; other site
398580009100	TPR repeat; Region: TPR_11; pfam13414
398580009101	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
398580009102	binding surface
398580009103	TPR motif; other site
398580009104	type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552
398580009105	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
398580009106	TPR motif; other site
398580009107	binding surface
398580009108	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
398580009109	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
398580009110	Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187
398580009111	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
398580009112	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
398580009113	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
398580009114	AzlC protein; Region: AzlC; pfam03591
398580009115	Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437
398580009116	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
398580009117	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
398580009118	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
398580009119	Disulphide bond corrector protein DsbC; Region: DsbC; cl15830
398580009120	hypothetical protein; Validated; Region: PRK00228
398580009121	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
398580009122	Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481
398580009123	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
398580009124	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
398580009125	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
398580009126	active site
398580009127	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
398580009128	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
398580009129	Bacterial aa3 type cytochrome c oxidase subunit IV; Region: COX4_pro_2; pfam07835
398580009130	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
398580009131	MPT binding site; other site
398580009132	trimer interface [polypeptide binding]; other site
398580009133	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
398580009134	Fe-S cluster binding site [ion binding]; other site
398580009135	active site
398580009136	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
398580009137	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
398580009138	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
398580009139	dihydroorotase; Validated; Region: PRK09059
398580009140	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
398580009141	active site
398580009142	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
398580009143	Protein of unknown function (DUF805); Region: DUF805; pfam05656
398580009144	glutamate--cysteine ligase; Region: PLN02611
398580009145	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
398580009146	RNA methyltransferase, RsmE family; Region: TIGR00046
398580009147	4-hydroxybenzoate polyprenyltransferase; Reviewed; Region: ubiA; PRK12878
398580009148	UbiA prenyltransferase family; Region: UbiA; pfam01040
398580009149	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
398580009150	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
398580009151	ligand binding site [chemical binding]; other site
398580009152	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
398580009153	MoaE homodimer interface [polypeptide binding]; other site
398580009154	MoaD interaction [polypeptide binding]; other site
398580009155	active site residues [active]
398580009156	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
398580009157	MoaE interaction surface [polypeptide binding]; other site
398580009158	MoeB interaction surface [polypeptide binding]; other site
398580009159	thiocarboxylated glycine; other site
398580009160	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
398580009161	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
398580009162	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
398580009163	active site
398580009164	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
398580009165	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
398580009166	Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435
398580009167	decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508
398580009168	Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168
398580009169	heme-binding residues [chemical binding]; other site
398580009170	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
398580009171	TPR motif; other site
398580009172	binding surface
398580009173	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
398580009174	global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697
398580009175	ligand binding site [chemical binding]; other site
398580009176	flexible hinge region; other site
398580009177	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
398580009178	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
398580009179	Sulfatase; Region: Sulfatase; pfam00884
398580009180	haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710
398580009181	MoxR-like ATPases [General function prediction only]; Region: COG0714
398580009182	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
398580009183	Walker A motif; other site
398580009184	ATP binding site [chemical binding]; other site
398580009185	Walker B motif; other site
398580009186	arginine finger; other site
398580009187	Protein of unknown function DUF58; Region: DUF58; pfam01882
398580009188	Domain of unknown function (DUF4381); Region: DUF4381; pfam14316
398580009189	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
398580009190	metal ion-dependent adhesion site (MIDAS); other site
398580009191	von Willebrand factor type A domain; Region: VWA_2; pfam13519
398580009192	metal ion-dependent adhesion site (MIDAS); other site
398580009193	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
398580009194	binding surface
398580009195	TPR motif; other site
398580009196	TPR repeat; Region: TPR_11; pfam13414
398580009197	Oxygen tolerance; Region: BatD; pfam13584
398580009198	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
398580009199	Citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CCL cleaves citryl-CoA (CiCoA) to acetyl-CoA (AcCoA) and oxaloacetate (OAA); Region: CCL_ACL-C; cd06100
398580009200	active site
398580009201	citrylCoA binding site [chemical binding]; other site
398580009202	oxalacetate binding site [chemical binding]; other site
398580009203	coenzyme A binding site [chemical binding]; other site
398580009204	catalytic triad [active]
398580009205	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
398580009206	CoA-transferase family III; Region: CoA_transf_3; pfam02515
398580009207	Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772
398580009208	Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331
398580009209	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
398580009210	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
398580009211	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
398580009212	active site
398580009213	phosphorylation site [posttranslational modification]
398580009214	intermolecular recognition site; other site
398580009215	dimerization interface [polypeptide binding]; other site
398580009216	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
398580009217	DNA binding site [nucleotide binding]
398580009218	Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521
398580009219	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
398580009220	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
398580009221	dimer interface [polypeptide binding]; other site
398580009222	phosphorylation site [posttranslational modification]
398580009223	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
398580009224	ATP binding site [chemical binding]; other site
398580009225	G-X-G motif; other site
398580009226	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
398580009227	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
398580009228	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
398580009229	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
398580009230	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
398580009231	Walker A/P-loop; other site
398580009232	ATP binding site [chemical binding]; other site
398580009233	Q-loop/lid; other site
398580009234	ABC transporter signature motif; other site
398580009235	Walker B; other site
398580009236	D-loop; other site
398580009237	H-loop/switch region; other site
398580009238	TOBE domain; Region: TOBE_2; pfam08402
398580009239	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
398580009240	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
398580009241	Walker A/P-loop; other site
398580009242	ATP binding site [chemical binding]; other site
398580009243	Q-loop/lid; other site
398580009244	ABC transporter signature motif; other site
398580009245	Walker B; other site
398580009246	D-loop; other site
398580009247	H-loop/switch region; other site
398580009248	TOBE domain; Region: TOBE_2; pfam08402
398580009249	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
398580009250	putative PBP binding loops; other site
398580009251	dimer interface [polypeptide binding]; other site
398580009252	ABC-ATPase subunit interface; other site
398580009253	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
398580009254	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
398580009255	dimer interface [polypeptide binding]; other site
398580009256	conserved gate region; other site
398580009257	putative PBP binding loops; other site
398580009258	ABC-ATPase subunit interface; other site
398580009259	Predicted small integral membrane protein (DUF2160); Region: DUF2160; pfam09928
398580009260	Penicillinase repressor; Region: Pencillinase_R; pfam03965
398580009261	Antirepressor regulating drug resistance, predicted signal transduction N-terminal membrane component [Transcription / Signal transduction mechanisms]; Region: MecR1; COG4219
398580009262	Protein of unknown function (DUF2927); Region: DUF2927; pfam11150
398580009263	Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480
398580009264	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
398580009265	Cupin domain; Region: Cupin_2; cl17218
398580009266	Transcriptional regulators [Transcription]; Region: PurR; COG1609
398580009267	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
398580009268	DNA binding site [nucleotide binding]
398580009269	domain linker motif; other site
398580009270	Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_2; cd06278
398580009271	putative ligand binding site [chemical binding]; other site
398580009272	putative dimerization interface [polypeptide binding]; other site
398580009273	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
398580009274	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
398580009275	Walker A/P-loop; other site
398580009276	ATP binding site [chemical binding]; other site
398580009277	Q-loop/lid; other site
398580009278	ABC transporter signature motif; other site
398580009279	Walker B; other site
398580009280	D-loop; other site
398580009281	H-loop/switch region; other site
398580009282	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
398580009283	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
398580009284	dimer interface [polypeptide binding]; other site
398580009285	conserved gate region; other site
398580009286	putative PBP binding loops; other site
398580009287	ABC-ATPase subunit interface; other site
398580009288	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
398580009289	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
398580009290	putative PBP binding loops; other site
398580009291	dimer interface [polypeptide binding]; other site
398580009292	ABC-ATPase subunit interface; other site
398580009293	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
398580009294	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
398580009295	HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231
398580009296	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
398580009297	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
398580009298	Type III secretion system lipoprotein chaperone (YscW); Region: YscW; cl15825
398580009299	META domain; Region: META; pfam03724
398580009300	D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813
398580009301	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
398580009302	D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558
398580009303	homodimer interface [polypeptide binding]; other site
398580009304	substrate-cofactor binding pocket; other site
398580009305	pyridoxal 5'-phosphate binding site [chemical binding]; other site
398580009306	catalytic residue [active]
398580009307	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
398580009308	transcriptional regulator, ArgP family; Region: argP; TIGR03298
398580009309	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
398580009310	dimerization interface [polypeptide binding]; other site
398580009311	hypothetical protein; Provisional; Region: PRK05463
398580009312	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
398580009313	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290
398580009314	DctM-like transporters; Region: DctM; pfam06808
398580009315	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
398580009316	Protein of unknown function (DUF2848); Region: DUF2848; pfam11010
398580009317	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
398580009318	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
398580009319	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290
398580009320	DctM-like transporters; Region: DctM; pfam06808
398580009321	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
398580009322	cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554
398580009323	NapC/NirT cytochrome c family, N-terminal region; Region: Cytochrom_NNT; pfam03264
398580009324	Nitrate reductase cytochrome c-type subunit (NapB); Region: NapB; pfam03892
398580009325	quinol dehydrogenase membrane component; Provisional; Region: napH; PRK09477
398580009326	4Fe-4S binding domain; Region: Fer4_5; pfam12801
398580009327	4Fe-4S binding domain; Region: Fer4_5; pfam12801
398580009328	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
398580009329	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
398580009330	2-oxoglutarate-acceptor oxidoreductase subunit OorD; Reviewed; Region: oorD; PRK09626
398580009331	nitrate reductase catalytic subunit; Provisional; Region: PRK13532
398580009332	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
398580009333	[4Fe-4S] binding site [ion binding]; other site
398580009334	molybdopterin cofactor binding site; other site
398580009335	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791
398580009336	molybdopterin cofactor binding site; other site
398580009337	NapD protein; Region: NapD; pfam03927
398580009338	ferredoxin-type protein; Provisional; Region: PRK10194
398580009339	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
398580009340	4Fe-4S binding domain; Region: Fer4; pfam00037
398580009341	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
398580009342	ApbE family; Region: ApbE; pfam02424
398580009343	Cytochrome c2 [Energy production and conversion]; Region: COG3474
398580009344	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
398580009345	putative active site [active]
398580009346	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
398580009347	putative active site [active]
398580009348	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
398580009349	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
398580009350	Cytochrome D1 heme domain; Region: Cytochrom_D1; pfam02239
398580009351	heme d1 biosynthesis radical SAM protein NirJ; Region: rSAM_NirJ; TIGR04051
398580009352	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
398580009353	FeS/SAM binding site; other site
398580009354	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
398580009355	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
398580009356	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
398580009357	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
398580009358	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
398580009359	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
398580009360	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
398580009361	Cytochrome D1 heme domain; Region: Cytochrom_D1; pfam02239
398580009362	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
398580009363	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
398580009364	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
398580009365	active site
398580009366	SAM binding site [chemical binding]; other site
398580009367	homodimer interface [polypeptide binding]; other site
398580009368	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
398580009369	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
398580009370	Cytochrome D1 heme domain; Region: Cytochrom_D1; pfam02239
398580009371	FMN-binding domain; Region: FMN_bind; cl01081
398580009372	Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348
398580009373	4Fe-4S binding domain; Region: Fer4_5; pfam12801
398580009374	4Fe-4S binding domain; Region: Fer4_5; pfam12801
398580009375	NnrS protein; Region: NnrS; pfam05940
398580009376	Cytochrome c; Region: Cytochrom_C; pfam00034
398580009377	Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115
398580009378	Heme-copper oxidase subunit I.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane.  The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275
398580009379	Binuclear center (active site) [active]
398580009380	K-pathway; other site
398580009381	Putative proton exit pathway; other site
398580009382	MoxR-like ATPases [General function prediction only]; Region: COG0714
398580009383	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
398580009384	Walker A motif; other site
398580009385	ATP binding site [chemical binding]; other site
398580009386	Walker B motif; other site
398580009387	CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406
398580009388	Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548
398580009389	norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role  in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454
398580009390	metal ion-dependent adhesion site (MIDAS); other site
398580009391	Heme-copper oxidase subunit III.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211
398580009392	Subunit I/III interface [polypeptide binding]; other site
398580009393	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
398580009394	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
398580009395	ligand binding site [chemical binding]; other site
398580009396	flexible hinge region; other site
398580009397	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320
398580009398	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
398580009399	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
398580009400	substrate-cofactor binding pocket; other site
398580009401	pyridoxal 5'-phosphate binding site [chemical binding]; other site
398580009402	catalytic residue [active]
398580009403	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
398580009404	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
398580009405	ligand binding site [chemical binding]; other site
398580009406	flexible hinge region; other site
398580009407	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
398580009408	Regulator of nitric oxide reductase transcription [Transcription]; Region: NosR; COG3901
398580009409	ferredoxin-type protein, NapH/MauN family; Region: napH_; TIGR02163
398580009410	4Fe-4S binding domain; Region: Fer4_5; pfam12801
398580009411	nitrous-oxide reductase, TAT-dependent; Region: nitrous_NosZ_RR; TIGR04244
398580009412	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
398580009413	nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247
398580009414	parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804
398580009415	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
398580009416	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
398580009417	Walker A/P-loop; other site
398580009418	ATP binding site [chemical binding]; other site
398580009419	Q-loop/lid; other site
398580009420	ABC transporter signature motif; other site
398580009421	Walker B; other site
398580009422	D-loop; other site
398580009423	H-loop/switch region; other site
398580009424	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
398580009425	NosL; Region: NosL; pfam05573
398580009426	ApbE family; Region: ApbE; pfam02424
398580009427	hypothetical protein; Provisional; Region: PRK11171
398580009428	Cupin domain; Region: Cupin_2; pfam07883
398580009429	Cupin domain; Region: Cupin_2; pfam07883
398580009430	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150
398580009431	homotrimer interaction site [polypeptide binding]; other site
398580009432	putative active site [active]
398580009433	xanthine permease; Region: pbuX; TIGR03173
398580009434	Ureidoglycolate hydrolase; Region: Ureidogly_hydro; pfam04115
398580009435	Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194
398580009436	putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212
398580009437	Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977
398580009438	active site
398580009439	catalytic site [active]
398580009440	tetramer interface [polypeptide binding]; other site
398580009441	OHCU decarboxylase; Region: OHCU_decarbox; cl01251
398580009442	HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822
398580009443	active site
398580009444	homotetramer interface [polypeptide binding]; other site
398580009445	Transcriptional regulator [Transcription]; Region: LysR; COG0583
398580009446	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
398580009447	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
398580009448	putative effector binding pocket; other site
398580009449	dimerization interface [polypeptide binding]; other site
398580009450	Predicted membrane protein [Function unknown]; Region: COG3748
398580009451	Protein of unknown function (DUF989); Region: DUF989; pfam06181
398580009452	Cytochrome c; Region: Cytochrom_C; pfam00034
398580009453	Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111
398580009454	PLD-like domain; Region: PLDc_2; pfam13091
398580009455	putative active site [active]
398580009456	catalytic site [active]
398580009457	Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113
398580009458	PLD-like domain; Region: PLDc_2; pfam13091
398580009459	putative active site [active]
398580009460	catalytic site [active]
398580009461	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
398580009462	Cytochrome c; Region: Cytochrom_C; pfam00034
398580009463	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
398580009464	Moco binding site; other site
398580009465	metal coordination site [ion binding]; other site
398580009466	integrase; Provisional; Region: PRK09692
398580009467	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
398580009468	active site
398580009469	Int/Topo IB signature motif; other site
398580009470	DNA binding site [nucleotide binding]
398580009471	CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641
398580009472	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
398580009473	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
398580009474	CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cl08044
398580009475	CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-E; cl09608
398580009476	CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704
398580009477	CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cd09756
398580009478	CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cl08497
398580009479	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656
398580009480	CRISPR-associated protein (Cas_Cas2CT1978); Region: Cas_Cas2CT1978; pfam09707
398580009481	Helix-turn-helix domain; Region: HTH_17; pfam12728
398580009482	Helix-turn-helix domain; Region: HTH_17; pfam12728
398580009483	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495
398580009484	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
398580009485	active site
398580009486	Int/Topo IB signature motif; other site
398580009487	catalytic residues [active]
398580009488	DNA binding site [nucleotide binding]
398580009489	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
398580009490	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
398580009491	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
398580009492	2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621
398580009493	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
398580009494	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
398580009495	FeS/SAM binding site; other site
398580009496	beta-amylase; Region: PLN02905
398580009497	DNA Polymerase Y-family; Region: PolY_like; cd03468
398580009498	active site
398580009499	DNA binding site [nucleotide binding]
398580009500	Protein of unknown function (DUF2794); Region: DUF2794; pfam10984
398580009501	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
398580009502	NlpC/P60 family; Region: NLPC_P60; pfam00877
398580009503	Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260
398580009504	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
398580009505	interface (dimer of trimers) [polypeptide binding]; other site
398580009506	Substrate-binding/catalytic site; other site
398580009507	Zn-binding sites [ion binding]; other site
398580009508	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884
398580009509	active site clefts [active]
398580009510	zinc binding site [ion binding]; other site
398580009511	dimer interface [polypeptide binding]; other site
398580009512	Domain of unknown function (DUF897); Region: DUF897; cl01312
398580009513	Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432
398580009514	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
398580009515	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
398580009516	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
398580009517	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
398580009518	Uncharacterized conserved protein [Function unknown]; Region: COG2308
398580009519	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307
398580009520	A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168
398580009521	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
398580009522	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
398580009523	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
398580009524	Predicted proteasome-type protease [Posttranslational modification, protein turnover, chaperones]; Region: COG3484
398580009525	Bacterial proteasome, beta subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that...; Region: proteasome_beta_bacterial; cd03765
398580009526	flagellum-specific ATP synthase; Validated; Region: fliI; PRK08927
398580009527	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
398580009528	Walker A motif; other site
398580009529	ATP binding site [chemical binding]; other site
398580009530	Walker B motif; other site
398580009531	flagellar basal body rod protein FlgB; Provisional; Region: flgB; PRK12627
398580009532	flagellar basal body rod protein FlgC; Provisional; Region: flgC; PRK12632
398580009533	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
398580009534	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
398580009535	flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00790
398580009536	Bacterial export proteins, family 3; Region: Bac_export_3; pfam01313
398580009537	flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12690
398580009538	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
398580009539	flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490
398580009540	flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12691
398580009541	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
398580009542	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
398580009543	SAF-like; Region: SAF_2; pfam13144
398580009544	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
398580009545	flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249
398580009546	Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063
398580009547	Flagellar basal body-associated protein FliL; Region: FliL; pfam03748
398580009548	flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702
398580009549	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822
398580009550	Bacterial export proteins, family 1; Region: Bac_export_1; cl00734
398580009551	flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012
398580009552	FHIPEP family; Region: FHIPEP; pfam00771
398580009553	Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291
398580009554	flagellar motor protein MotA; Validated; Region: PRK09110
398580009555	Uncharacterized conserved protein [Function unknown]; Region: COG3334
398580009556	Flagellar basal body-associated protein FliL; Region: FliL; pfam03748
398580009557	flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007
398580009558	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907
398580009559	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
398580009560	Flagellar biosynthesis/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliH; COG1317
398580009561	Surface presentation of antigens (SPOA); Region: SpoA; cl00819
398580009562	flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699
398580009563	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term; Region: FrhB_FdhB_N; pfam04422
398580009564	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432
398580009565	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
398580009566	CoA-transferase family III; Region: CoA_transf_3; pfam02515
398580009567	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
398580009568	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
398580009569	ligand binding site [chemical binding]; other site
398580009570	flexible hinge region; other site
398580009571	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
398580009572	putative switch regulator; other site
398580009573	non-specific DNA interactions [nucleotide binding]; other site
398580009574	DNA binding site [nucleotide binding]
398580009575	sequence specific DNA binding site [nucleotide binding]; other site
398580009576	putative cAMP binding site [chemical binding]; other site
398580009577	Domain of unknown function DUF59; Region: DUF59; pfam01883
398580009578	cell division ATPase MinD, archaeal; Region: minD_arch; TIGR01969
398580009579	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
398580009580	Walker A motif; other site
398580009581	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185
398580009582	putative acyl-acceptor binding pocket; other site
398580009583	Tetratricopeptide repeat; Region: TPR_12; pfam13424
398580009584	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
398580009585	TPR motif; other site
398580009586	binding surface
398580009587	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
398580009588	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
398580009589	Tetramer interface [polypeptide binding]; other site
398580009590	active site
398580009591	FMN-binding site [chemical binding]; other site
398580009592	Cytochrome C1 family; Region: Cytochrom_C1; pfam02167
398580009593	cytochrome b; Provisional; Region: CYTB; MTH00191
398580009594	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284
398580009595	intrachain domain interface; other site
398580009596	interchain domain interface [polypeptide binding]; other site
398580009597	heme bH binding site [chemical binding]; other site
398580009598	Qi binding site; other site
398580009599	heme bL binding site [chemical binding]; other site
398580009600	Qo binding site; other site
398580009601	Cytochrome b(C-terminus)/b6/petD:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290
398580009602	interchain domain interface [polypeptide binding]; other site
398580009603	intrachain domain interface; other site
398580009604	Qi binding site; other site
398580009605	Qo binding site; other site
398580009606	Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal; Region: UCR_Fe-S_N; pfam10399
398580009607	ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416
398580009608	Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470
398580009609	[2Fe-2S] cluster binding site [ion binding]; other site
398580009610	putative glutathione S-transferase; Provisional; Region: PRK10357
398580009611	GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049
398580009612	putative C-terminal domain interface [polypeptide binding]; other site
398580009613	putative GSH binding site (G-site) [chemical binding]; other site
398580009614	putative dimer interface [polypeptide binding]; other site
398580009615	C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205
398580009616	dimer interface [polypeptide binding]; other site
398580009617	N-terminal domain interface [polypeptide binding]; other site
398580009618	putative substrate binding pocket (H-site) [chemical binding]; other site
398580009619	YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486
398580009620	generic binding surface I; other site
398580009621	generic binding surface II; other site
398580009622	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
398580009623	putative catalytic site [active]
398580009624	putative metal binding site [ion binding]; other site
398580009625	putative phosphate binding site [ion binding]; other site
398580009626	FdhD/NarQ family; Region: FdhD-NarQ; pfam02634
398580009627	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
398580009628	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
398580009629	GTP binding site; other site
398580009630	putative bifunctional molybdopterin-guanine dinucleotide biosynthesis protein MobB/MoeA; Provisional; Region: PRK14491
398580009631	Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116
398580009632	Walker A motif; other site
398580009633	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
398580009634	dimer interface [polypeptide binding]; other site
398580009635	putative functional site; other site
398580009636	putative MPT binding site; other site
398580009637	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
398580009638	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
398580009639	catalytic residues [active]
398580009640	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
398580009641	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
398580009642	EamA-like transporter family; Region: EamA; pfam00892
398580009643	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
398580009644	IHF dimer interface [polypeptide binding]; other site
398580009645	IHF - DNA interface [nucleotide binding]; other site
398580009646	AMP nucleosidase; Provisional; Region: PRK08292
398580009647	Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423
398580009648	Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775
398580009649	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
398580009650	Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681
398580009651	active site
398580009652	atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266
398580009653	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
398580009654	putative NAD(P) binding site [chemical binding]; other site
398580009655	Glycosyl transferase family 2; Region: Glyco_tranf_2_4; pfam13704
398580009656	Methyltransferase FkbM domain; Region: Methyltransf_21; cl17387
398580009657	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
398580009658	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
398580009659	TPP-binding site; other site
398580009660	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
398580009661	PYR/PP interface [polypeptide binding]; other site
398580009662	dimer interface [polypeptide binding]; other site
398580009663	TPP binding site [chemical binding]; other site
398580009664	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
398580009665	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
398580009666	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
398580009667	substrate binding pocket [chemical binding]; other site
398580009668	chain length determination region; other site
398580009669	substrate-Mg2+ binding site; other site
398580009670	catalytic residues [active]
398580009671	aspartate-rich region 1; other site
398580009672	active site lid residues [active]
398580009673	aspartate-rich region 2; other site
398580009674	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
398580009675	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
398580009676	Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_2; cd11599
398580009677	putative active site [active]
398580009678	Zn binding site [ion binding]; other site
398580009679	osmolarity response regulator; Provisional; Region: ompR; PRK09468
398580009680	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
398580009681	active site
398580009682	phosphorylation site [posttranslational modification]
398580009683	intermolecular recognition site; other site
398580009684	dimerization interface [polypeptide binding]; other site
398580009685	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
398580009686	DNA binding site [nucleotide binding]
398580009687	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
398580009688	MarR family; Region: MarR_2; pfam12802
398580009689	branched-chain amino acid aminotransferase; Validated; Region: PRK07544
398580009690	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
398580009691	homodimer interface [polypeptide binding]; other site
398580009692	substrate-cofactor binding pocket; other site
398580009693	pyridoxal 5'-phosphate binding site [chemical binding]; other site
398580009694	catalytic residue [active]
398580009695	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
398580009696	HupE / UreJ protein; Region: HupE_UreJ_2; pfam13795
398580009697	Domain of unknown function (DUF4198); Region: DUF4198; pfam10670
398580009698	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
398580009699	EamA-like transporter family; Region: EamA; pfam00892
398580009700	epoxyqueuosine reductase; Region: TIGR00276
398580009701	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
398580009702	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
398580009703	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
398580009704	C-terminal domain interface [polypeptide binding]; other site
398580009705	GSH binding site (G-site) [chemical binding]; other site
398580009706	dimer interface [polypeptide binding]; other site
398580009707	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299
398580009708	N-terminal domain interface [polypeptide binding]; other site
398580009709	dimer interface [polypeptide binding]; other site
398580009710	substrate binding pocket (H-site) [chemical binding]; other site
398580009711	Transglycosylase; Region: Transgly; cl17702
398580009712	hypothetical protein; Provisional; Region: PRK10279
398580009713	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
398580009714	nucleophile elbow; other site
398580009715	Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820
398580009716	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377
398580009717	FeS/SAM binding site; other site
398580009718	ChrR Cupin-like domain; Region: Cupin_7; pfam12973
398580009719	Invasion associated locus B (IalB) protein; Region: IalB; cl02207
398580009720	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
398580009721	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
398580009722	motif II; other site
398580009723	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cd01494
398580009724	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
398580009725	catalytic residue [active]
398580009726	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581
398580009727	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
398580009728	ligand binding site [chemical binding]; other site
398580009729	NAD binding site [chemical binding]; other site
398580009730	dimerization interface [polypeptide binding]; other site
398580009731	catalytic site [active]
398580009732	C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902
398580009733	putative L-serine binding site [chemical binding]; other site
398580009734	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
398580009735	phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144
398580009736	active site
398580009737	metal binding site [ion binding]; metal-binding site
398580009738	Uncharacterized protein conserved in bacteria [Function unknown]; Region: CreA; COG3045
398580009739	CreA protein; Region: CreA; pfam05981
398580009740	Transcriptional regulators [Transcription]; Region: PurR; COG1609
398580009741	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
398580009742	DNA binding site [nucleotide binding]
398580009743	domain linker motif; other site
398580009744	Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575
398580009745	putative dimerization interface [polypeptide binding]; other site
398580009746	putative ligand binding site [chemical binding]; other site
398580009747	Transcriptional regulators [Transcription]; Region: GntR; COG1802
398580009748	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
398580009749	DNA-binding site [nucleotide binding]; DNA binding site
398580009750	FCD domain; Region: FCD; pfam07729
398580009751	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
398580009752	FAD binding domain; Region: FAD_binding_4; pfam01565
398580009753	4Fe-4S dicluster domain; Region: Fer4_8; pfam13183
398580009754	sn-glycerol-3-phosphate dehydrogenase subunit C; Provisional; Region: glpC; PRK11168
398580009755	Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451
398580009756	homodimer interface [polypeptide binding]; other site
398580009757	pyridoxal 5'-phosphate binding site [chemical binding]; other site
398580009758	catalytic residue [active]
398580009759	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
398580009760	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
398580009761	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181
398580009762	DctM-like transporters; Region: DctM; pfam06808
398580009763	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
398580009764	enoyl-CoA hydratase; Provisional; Region: PRK06144
398580009765	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
398580009766	substrate binding site [chemical binding]; other site
398580009767	oxyanion hole (OAH) forming residues; other site
398580009768	trimer interface [polypeptide binding]; other site
398580009769	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
398580009770	CoA-transferase family III; Region: CoA_transf_3; pfam02515
398580009771	beta-ketothiolase; Provisional; Region: PRK09051
398580009772	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
398580009773	dimer interface [polypeptide binding]; other site
398580009774	active site
398580009775	PAS fold; Region: PAS_7; pfam12860
398580009776	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
398580009777	dimer interface [polypeptide binding]; other site
398580009778	phosphorylation site [posttranslational modification]
398580009779	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
398580009780	ATP binding site [chemical binding]; other site
398580009781	Mg2+ binding site [ion binding]; other site
398580009782	G-X-G motif; other site
398580009783	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
398580009784	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
398580009785	active site
398580009786	phosphorylation site [posttranslational modification]
398580009787	intermolecular recognition site; other site
398580009788	dimerization interface [polypeptide binding]; other site
398580009789	Response regulator receiver domain; Region: Response_reg; pfam00072
398580009790	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
398580009791	active site
398580009792	phosphorylation site [posttranslational modification]
398580009793	intermolecular recognition site; other site
398580009794	dimerization interface [polypeptide binding]; other site
398580009795	Protein of unknown function (DUF328); Region: DUF328; pfam03883
398580009796	Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514
398580009797	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
398580009798	ATP binding site [chemical binding]; other site
398580009799	putative Mg++ binding site [ion binding]; other site
398580009800	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
398580009801	nucleotide binding region [chemical binding]; other site
398580009802	ATP-binding site [chemical binding]; other site
398580009803	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
398580009804	HRDC domain; Region: HRDC; pfam00570
398580009805	HRDC domain; Region: HRDC; cl02578
398580009806	YGGT family; Region: YGGT; pfam02325
398580009807	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
398580009808	active site
398580009809	Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270
398580009810	penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429
398580009811	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4246
398580009812	Esterase-like activity of phytase; Region: Phytase-like; pfam13449
398580009813	Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; cl00756
398580009814	Uncharacterized protein conserved in archaea [Posttranslational modification, protein turnover, chaperones]; Region: COG4067
398580009815	ribosomal protein S6 modification protein; Provisional; Region: PRK10446
398580009816	ATP-grasp domain; Region: ATP-grasp_4; cl17255
398580009817	hypothetical protein; Provisional; Region: PRK09256
398580009818	Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186
398580009819	4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160
398580009820	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
398580009821	inhibitor-cofactor binding pocket; inhibition site
398580009822	pyridoxal 5'-phosphate binding site [chemical binding]; other site
398580009823	catalytic residue [active]
398580009824	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
398580009825	Phosphotransferase enzyme family; Region: APH; pfam01636
398580009826	active site
398580009827	ATP binding site [chemical binding]; other site
398580009828	Nicotinic acid phosphoribosyltransferase [Coenzyme metabolism]; Region: PncB; COG1488
398580009829	nicotinate phosphoribosyltransferase; Provisional; Region: PRK05321
398580009830	active site
398580009831	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
398580009832	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
398580009833	putative active site [active]
398580009834	heme pocket [chemical binding]; other site
398580009835	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
398580009836	dimer interface [polypeptide binding]; other site
398580009837	phosphorylation site [posttranslational modification]
398580009838	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
398580009839	ATP binding site [chemical binding]; other site
398580009840	Mg2+ binding site [ion binding]; other site
398580009841	G-X-G motif; other site
398580009842	Response regulator receiver domain; Region: Response_reg; pfam00072
398580009843	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
398580009844	active site
398580009845	phosphorylation site [posttranslational modification]
398580009846	intermolecular recognition site; other site
398580009847	dimerization interface [polypeptide binding]; other site
398580009848	Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011
398580009849	Isochorismatase family; Region: Isochorismatase; pfam00857
398580009850	catalytic triad [active]
398580009851	metal binding site [ion binding]; metal-binding site
398580009852	conserved cis-peptide bond; other site
398580009853	Predicted sulfurtransferase [General function prediction only]; Region: COG1054
398580009854	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
398580009855	active site residue [active]
398580009856	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
398580009857	tRNA 2-selenouridine synthase; Region: tRNA_sel_U_synt; TIGR03167
398580009858	active site residue [active]
398580009859	pyridine nucleotide-disulfide oxidoreductase family protein; Region: Nterm_to_SelD; TIGR03169
398580009860	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
398580009861	Selenophosphate synthetase  (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195
398580009862	Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypE; COG0309
398580009863	dimerization interface [polypeptide binding]; other site
398580009864	putative ATP binding site [chemical binding]; other site
398580009865	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
398580009866	Hydroxyneurosporene synthase (CrtC); Region: CrtC; cl12101
398580009867	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
398580009868	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
398580009869	Walker A/P-loop; other site
398580009870	ATP binding site [chemical binding]; other site
398580009871	Q-loop/lid; other site
398580009872	ABC transporter signature motif; other site
398580009873	Walker B; other site
398580009874	D-loop; other site
398580009875	H-loop/switch region; other site
398580009876	DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939
398580009877	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
398580009878	Mg2+ binding site [ion binding]; other site
398580009879	G-X-G motif; other site
398580009880	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
398580009881	anchoring element; other site
398580009882	dimer interface [polypeptide binding]; other site
398580009883	ATP binding site [chemical binding]; other site
398580009884	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
398580009885	active site
398580009886	putative metal-binding site [ion binding]; other site
398580009887	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
398580009888	Transposase; Region: HTH_Tnp_1; pfam01527
398580009889	HTH-like domain; Region: HTH_21; pfam13276
398580009890	Integrase core domain; Region: rve; pfam00665
398580009891	Integrase core domain; Region: rve_3; pfam13683
398580009892	Protein of unknown function (DUF1217); Region: DUF1217; pfam06748
398580009893	Protein of unknown function (DUF1217); Region: DUF1217; pfam06748
398580009894	Flagellar protein FlbT; Region: FlbT; pfam07378
398580009895	flagellar biosynthesis regulatory protein FlaF; Reviewed; Region: flaF; PRK12794
398580009896	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
398580009897	flagellin; Provisional; Region: PRK12806
398580009898	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
398580009899	Rod binding protein; Region: Rod-binding; pfam10135
398580009900	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
398580009901	flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK12813
398580009902	Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963
398580009903	FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861
398580009904	Phosphotransferase enzyme family; Region: APH; pfam01636
398580009905	Protein of unknown function (DUF1679); Region: DUF1679; pfam07914
398580009906	ABC1 family; Region: ABC1; cl17513
398580009907	2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982
398580009908	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
398580009909	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
398580009910	S-adenosylmethionine binding site [chemical binding]; other site
398580009911	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
398580009912	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
398580009913	DNA binding site [nucleotide binding]
398580009914	catalytic residue [active]
398580009915	H2TH interface [polypeptide binding]; other site
398580009916	putative catalytic residues [active]
398580009917	turnover-facilitating residue; other site
398580009918	intercalation triad [nucleotide binding]; other site
398580009919	8OG recognition residue [nucleotide binding]; other site
398580009920	putative reading head residues; other site
398580009921	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
398580009922	enoyl-CoA hydratase; Provisional; Region: PRK05862
398580009923	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
398580009924	substrate binding site [chemical binding]; other site
398580009925	oxyanion hole (OAH) forming residues; other site
398580009926	trimer interface [polypeptide binding]; other site
398580009927	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
398580009928	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
398580009929	active site residue [active]
398580009930	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
398580009931	DnaA N-terminal domain; Region: DnaA_N; pfam11638
398580009932	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
398580009933	Walker A motif; other site
398580009934	ATP binding site [chemical binding]; other site
398580009935	Walker B motif; other site
398580009936	arginine finger; other site
398580009937	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
398580009938	DnaA box-binding interface [nucleotide binding]; other site
398580009939	DNA polymerase III subunit beta; Validated; Region: PRK05643
398580009940	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
398580009941	putative DNA binding surface [nucleotide binding]; other site
398580009942	dimer interface [polypeptide binding]; other site
398580009943	beta-clamp/clamp loader binding surface; other site
398580009944	beta-clamp/translesion DNA polymerase binding surface; other site
398580009945	recombination protein F; Reviewed; Region: recF; PRK00064
398580009946	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
398580009947	Walker A/P-loop; other site
398580009948	ATP binding site [chemical binding]; other site
398580009949	Q-loop/lid; other site
398580009950	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
398580009951	ABC transporter signature motif; other site
398580009952	Walker B; other site
398580009953	D-loop; other site
398580009954	H-loop/switch region; other site
398580009955	flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622
398580009956	Flagellar P-ring protein; Region: FlgI; pfam02119
398580009957	flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK06008
398580009958	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
398580009959	flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07521
398580009960	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
398580009961	flagellar hook protein FlgE; Validated; Region: flgE; PRK05682
398580009962	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
398580009963	Flagellar basal body protein FlaE; Region: FlaE; pfam07559
398580009964	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
398580009965	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
398580009966	Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360
398580009967	OmpA family; Region: OmpA; pfam00691
398580009968	ligand binding site [chemical binding]; other site
398580009969	Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729
398580009970	Surface antigen; Region: Bac_surface_Ag; pfam01103
398580009971	Family of unknown function (DUF490); Region: DUF490; pfam04357
398580009972	Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
398580009973	Predicted membrane protein [Function unknown]; Region: COG4083; cl15694
398580009974	exosortase D, VPLPA-CTERM-specific; Region: exosort_VPLPA; TIGR04152
398580009975	Protein of unknown function (DUF3485); Region: DUF3485; pfam11984
398580009976	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
398580009977	binding surface
398580009978	TPR motif; other site
398580009979	TPR repeat; Region: TPR_11; pfam13414
398580009980	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
398580009981	TPR motif; other site
398580009982	binding surface
398580009983	TPR repeat; Region: TPR_11; pfam13414
398580009984	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
398580009985	TPR motif; other site
398580009986	Bacterial sugar transferase; Region: Bac_transf; pfam02397
398580009987	putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015
398580009988	AAA ATPase domain; Region: AAA_16; pfam13191
398580009989	polysaccharide chain length determinant protein, PEP-CTERM locus subfamily; Region: pepcterm_ChnLen; TIGR03007
398580009990	AAA domain; Region: AAA_31; pfam13614
398580009991	phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144
398580009992	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
398580009993	active site
398580009994	metal binding site [ion binding]; metal-binding site
398580009995	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
398580009996	Uncharacterized conserved protein [Function unknown]; Region: COG1359
398580009997	Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473
398580009998	tartrate dehydrogenase; Region: TTC; TIGR02089
398580009999	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
398580010000	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
398580010001	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
398580010002	TRAP-type mannitol/chloroaromatic compound transport system, large permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT3; COG4664
398580010003	DctM-like transporters; Region: DctM; pfam06808
398580010004	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181
398580010005	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
398580010006	DDE superfamily endonuclease; Region: DDE_3; pfam13358
398580010007	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
398580010008	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
398580010009	Homeodomain-like domain; Region: HTH_23; cl17451
398580010010	Methyltransferase domain; Region: Methyltransf_23; pfam13489
398580010011	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
398580010012	S-adenosylmethionine binding site [chemical binding]; other site
398580010013	Phospholipid methyltransferase; Region: PEMT; cl17370
398580010014	Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases are important virulence factors in pathogenic bacteria. They may be secreted into the medium via a mechanism found in gram-negative bacteria, that does not...; Region: ZnMc_serralysin_like; cd04277
398580010015	active site
398580010016	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
398580010017	AMP-binding domain protein; Validated; Region: PRK08315
398580010018	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
398580010019	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917
398580010020	acyl-activating enzyme (AAE) consensus motif; other site
398580010021	putative AMP binding site [chemical binding]; other site
398580010022	putative active site [active]
398580010023	putative CoA binding site [chemical binding]; other site
398580010024	Copper chaperone [Inorganic ion transport and metabolism]; Region: CopZ; COG2608
398580010025	metal-binding site [ion binding]
398580010026	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
398580010027	DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023
398580010028	catalytic residues [active]
398580010029	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
398580010030	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
398580010031	Disulphide bond corrector protein DsbC; Region: DsbC; cl15830
398580010032	Thiol:disulfide interchange protein [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4232
398580010033	DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953
398580010034	DsbD alpha interface [polypeptide binding]; other site
398580010035	catalytic residues [active]
398580010036	cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142
398580010037	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
398580010038	binding surface
398580010039	TPR motif; other site
398580010040	Cytochrome C biogenesis protein; Region: CcmH; pfam03918
398580010041	TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010
398580010042	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
398580010043	catalytic residues [active]
398580010044	central insert; other site
398580010045	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138
398580010046	EVE domain; Region: EVE; cl00728
398580010047	YciI-like protein; Reviewed; Region: PRK12863
398580010048	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
398580010049	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
398580010050	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
398580010051	UGMP family protein; Validated; Region: PRK09604
398580010052	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884
398580010053	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
398580010054	active site
398580010055	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4223
398580010056	HemY protein N-terminus; Region: HemY_N; pfam07219
398580010057	Uncharacterized membrane-bound protein [Function unknown]; Region: COG3898
398580010058	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
398580010059	Amidase; Region: Amidase; pfam01425
398580010060	Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554
398580010061	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
398580010062	N- and C-terminal domain interface [polypeptide binding]; other site
398580010063	active site
398580010064	MgATP binding site [chemical binding]; other site
398580010065	catalytic site [active]
398580010066	metal binding site [ion binding]; metal-binding site
398580010067	glycerol binding site [chemical binding]; other site
398580010068	homotetramer interface [polypeptide binding]; other site
398580010069	homodimer interface [polypeptide binding]; other site
398580010070	FBP binding site [chemical binding]; other site
398580010071	protein IIAGlc interface [polypeptide binding]; other site
398580010072	Peptidase S8 family domain, uncharacterized subfamily 4; Region: Peptidases_S8_4; cd05561
398580010073	active site
398580010074	catalytic triad [active]
398580010075	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
398580010076	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
398580010077	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
398580010078	DNA binding residues [nucleotide binding]
398580010079	Protein of unknown function (DUF2853); Region: DUF2853; pfam11015
398580010080	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
398580010081	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
398580010082	homotetramer interface [polypeptide binding]; other site
398580010083	ligand binding site [chemical binding]; other site
398580010084	catalytic site [active]
398580010085	NAD binding site [chemical binding]; other site
398580010086	A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194
398580010087	Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501
398580010088	Ligand binding site; other site
398580010089	metal-binding site
398580010090	Predicted hydrolases of HD superfamily [General function prediction only]; Region: COG1896
398580010091	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567
398580010092	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
398580010093	active site
398580010094	phosphorylation site [posttranslational modification]
398580010095	intermolecular recognition site; other site
398580010096	dimerization interface [polypeptide binding]; other site
398580010097	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
398580010098	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
398580010099	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
398580010100	Cu(I) binding site [ion binding]; other site
398580010101	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
398580010102	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
398580010103	dimer interface [polypeptide binding]; other site
398580010104	phosphorylation site [posttranslational modification]
398580010105	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
398580010106	ATP binding site [chemical binding]; other site
398580010107	Mg2+ binding site [ion binding]; other site
398580010108	G-X-G motif; other site
398580010109	PAS fold; Region: PAS_7; pfam12860
398580010110	PAS fold; Region: PAS_7; pfam12860
398580010111	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
398580010112	Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178
398580010113	Phosphotransferase enzyme family; Region: APH; pfam01636
398580010114	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
398580010115	NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422
398580010116	Substrate binding site; other site
398580010117	metal-binding site
398580010118	double-strand break repair protein AddB, alphaproteobacterial type; Region: addB_alphas; TIGR02786
398580010119	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
398580010120	Part of AAA domain; Region: AAA_19; pfam13245
398580010121	double-strand break repair helicase AddA, alphaproteobacterial type; Region: addA_alphas; TIGR02784
398580010122	Family description; Region: UvrD_C_2; pfam13538
398580010123	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
398580010124	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
398580010125	catalytic residues [active]
398580010126	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
398580010127	active site
398580010128	HslU subunit interaction site [polypeptide binding]; other site
398580010129	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
398580010130	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
398580010131	Walker A motif; other site
398580010132	ATP binding site [chemical binding]; other site
398580010133	AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724
398580010134	Walker B motif; other site
398580010135	arginine finger; other site
398580010136	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
398580010137	Major Facilitator Superfamily; Region: MFS_1; pfam07690
398580010138	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
398580010139	putative substrate translocation pore; other site
398580010140	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840
398580010141	Smr domain; Region: Smr; pfam01713
398580010142	Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821
398580010143	MltA specific insert domain; Region: MltA; smart00925
398580010144	3D domain; Region: 3D; pfam06725
398580010145	Tim44-like domain; Region: Tim44; pfam04280
398580010146	FxsA cytoplasmic membrane protein; Region: FxsA; pfam04186
398580010147	Preprotein translocase subunit SecB; Region: SecB; pfam02556
398580010148	SecA binding site; other site
398580010149	Preprotein binding site; other site
398580010150	DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406
398580010151	DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131
398580010152	active site
398580010153	catalytic site [active]
398580010154	substrate binding site [chemical binding]; other site
398580010155	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
398580010156	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
398580010157	CoA-binding site [chemical binding]; other site
398580010158	ATP-binding [chemical binding]; other site
398580010159	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
398580010160	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
398580010161	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
398580010162	shikimate binding site; other site
398580010163	NAD(P) binding site [chemical binding]; other site
398580010164	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
398580010165	active site
398580010166	dimer interface [polypeptide binding]; other site
398580010167	Uncharacterized protein family (UPF0093); Region: UPF0093; pfam03653
398580010168	transcription termination factor Rho; Provisional; Region: rho; PRK09376
398580010169	Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498
398580010170	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
398580010171	RNA binding site [nucleotide binding]; other site
398580010172	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
398580010173	multimer interface [polypeptide binding]; other site
398580010174	Walker A motif; other site
398580010175	ATP binding site [chemical binding]; other site
398580010176	Walker B motif; other site
398580010177	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
398580010178	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
398580010179	trmE is a tRNA modification GTPase; Region: trmE; cd04164
398580010180	G1 box; other site
398580010181	GTP/Mg2+ binding site [chemical binding]; other site
398580010182	Switch I region; other site
398580010183	G2 box; other site
398580010184	Switch II region; other site
398580010185	G3 box; other site
398580010186	G4 box; other site
398580010187	G5 box; other site
398580010188	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
398580010189	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
398580010190	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
398580010191	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
398580010192	rRNA small subunit methyltransferase G; Region: GidB; pfam02527
398580010193	16S rRNA methyltransferase GidB; Reviewed; Region: gidB; cl17726
398580010194	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
398580010195	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
398580010196	P-loop; other site
398580010197	Magnesium ion binding site [ion binding]; other site
398580010198	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
398580010199	Magnesium ion binding site [ion binding]; other site
398580010200	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
398580010201	ParB-like nuclease domain; Region: ParB; smart00470
398580010202	Protein of unknown function (DUF454); Region: DUF454; cl01063
398580010203	coproporphyrinogen III oxidase; Provisional; Region: PRK09057
398580010204	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
398580010205	FeS/SAM binding site; other site
398580010206	HemN C-terminal domain; Region: HemN_C; pfam06969
398580010207	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154
398580010208	homotrimer interaction site [polypeptide binding]; other site
398580010209	putative active site [active]
398580010210	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
398580010211	active site
398580010212	dimerization interface [polypeptide binding]; other site
398580010213	ribonuclease PH; Reviewed; Region: rph; PRK00173
398580010214	Ribonuclease PH; Region: RNase_PH_bact; cd11362
398580010215	hexamer interface [polypeptide binding]; other site
398580010216	active site
398580010217	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
398580010218	Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444
398580010219	GrpE; Region: GrpE; pfam01025
398580010220	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
398580010221	dimer interface [polypeptide binding]; other site
398580010222	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
398580010223	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
398580010224	MutS domain I; Region: MutS_I; pfam01624
398580010225	MutS domain II; Region: MutS_II; pfam05188
398580010226	MutS domain III; Region: MutS_III; pfam05192
398580010227	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
398580010228	Walker A/P-loop; other site
398580010229	ATP binding site [chemical binding]; other site
398580010230	Q-loop/lid; other site
398580010231	ABC transporter signature motif; other site
398580010232	Walker B; other site
398580010233	D-loop; other site
398580010234	H-loop/switch region; other site
398580010235	bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232
398580010236	Malic enzyme, N-terminal domain; Region: malic; pfam00390
398580010237	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
398580010238	putative NAD(P) binding site [chemical binding]; other site
398580010239	Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280
398580010240	Peptide methionine sulfoxide reductase; Region: PMSR; cl00366
398580010241	Peptidase family M48; Region: Peptidase_M48; cl12018
398580010242	Bacterial protein of unknown function (DUF898); Region: DUF898; pfam05987
398580010243	argininosuccinate synthase; Provisional; Region: PRK13820
398580010244	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
398580010245	ANP binding site [chemical binding]; other site
398580010246	Substrate Binding Site II [chemical binding]; other site
398580010247	Substrate Binding Site I [chemical binding]; other site
398580010248	threonine dehydratase; Validated; Region: PRK08639
398580010249	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
398580010250	tetramer interface [polypeptide binding]; other site
398580010251	pyridoxal 5'-phosphate binding site [chemical binding]; other site
398580010252	catalytic residue [active]
398580010253	Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907
398580010254	putative Ile/Val binding site [chemical binding]; other site
398580010255	3-carboxy-cis,cis-muconate cycloisomerase; Provisional; Region: PRK05975
398580010256	tetramer interface [polypeptide binding]; other site
398580010257	Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853
398580010258	Protocatechuate 3,4-dioxygenase beta subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PcaH; COG3485
398580010259	Protocatechuate 3,4-dioxygenase (3,4-PCD) , alpha subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_alpha; cd03463
398580010260	heterodimer interface [polypeptide binding]; other site
398580010261	active site
398580010262	Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208
398580010263	protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422
398580010264	active site
398580010265	4-carboxymuconolactone decarboxylase; Region: decarb_PcaC; TIGR02425
398580010266	4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243
398580010267	PAAR motif; Region: PAAR_motif; cl15808
398580010268	N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; cl17549
398580010269	molybdate transporter periplasmic protein; Provisional; Region: modA; PRK10677
398580010270	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
398580010271	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
398580010272	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
398580010273	dimer interface [polypeptide binding]; other site
398580010274	conserved gate region; other site
398580010275	putative PBP binding loops; other site
398580010276	ABC-ATPase subunit interface; other site
398580010277	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
398580010278	ABC-type molybdate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: ModC; COG4148
398580010279	Walker A/P-loop; other site
398580010280	ATP binding site [chemical binding]; other site
398580010281	Q-loop/lid; other site
398580010282	ABC transporter signature motif; other site
398580010283	Walker B; other site
398580010284	D-loop; other site
398580010285	H-loop/switch region; other site
398580010286	TOBE domain; Region: TOBE; cl01440
398580010287	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086
398580010288	putative binding surface; other site
398580010289	active site
398580010290	Response regulator receiver domain; Region: Response_reg; pfam00072
398580010291	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
398580010292	active site
398580010293	phosphorylation site [posttranslational modification]
398580010294	intermolecular recognition site; other site
398580010295	dimerization interface [polypeptide binding]; other site
398580010296	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
398580010297	Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684
398580010298	nudix motif; other site
398580010299	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
398580010300	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
398580010301	dimerization interface [polypeptide binding]; other site
398580010302	domain crossover interface; other site
398580010303	redox-dependent activation switch; other site
398580010304	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
398580010305	putative active site [active]
398580010306	putative CoA binding site [chemical binding]; other site
398580010307	nudix motif; other site
398580010308	metal binding site [ion binding]; metal-binding site
398580010309	tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617
398580010310	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
398580010311	active site
398580010312	NTP binding site [chemical binding]; other site
398580010313	metal binding triad [ion binding]; metal-binding site
398580010314	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
398580010315	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
398580010316	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
398580010317	Walker A/P-loop; other site
398580010318	ATP binding site [chemical binding]; other site
398580010319	Q-loop/lid; other site
398580010320	ABC transporter signature motif; other site
398580010321	Walker B; other site
398580010322	D-loop; other site
398580010323	H-loop/switch region; other site
398580010324	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
398580010325	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
398580010326	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
398580010327	Walker A/P-loop; other site
398580010328	ATP binding site [chemical binding]; other site
398580010329	Q-loop/lid; other site
398580010330	ABC transporter signature motif; other site
398580010331	Walker B; other site
398580010332	D-loop; other site
398580010333	H-loop/switch region; other site
398580010334	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
398580010335	Ion transport protein; Region: Ion_trans; pfam00520
398580010336	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
398580010337	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
398580010338	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
398580010339	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
398580010340	ferrochelatase; Reviewed; Region: hemH; PRK00035
398580010341	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
398580010342	C-terminal domain interface [polypeptide binding]; other site
398580010343	active site
398580010344	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
398580010345	active site
398580010346	N-terminal domain interface [polypeptide binding]; other site
398580010347	biotin biosynthesis protein BioC; Region: BioC; TIGR02072
398580010348	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
398580010349	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
398580010350	magnesium chelatase subunit I; Provisional; Region: bchI; PRK13407
398580010351	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
398580010352	Walker A motif; other site
398580010353	ATP binding site [chemical binding]; other site
398580010354	Walker B motif; other site
398580010355	arginine finger; other site
398580010356	magnesium chelatase subunit D; Provisional; Region: bchD; PRK13406
398580010357	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
398580010358	metal ion-dependent adhesion site (MIDAS); other site
398580010359	putative magnesium chelatase accessory protein; Region: bchO_mg_che_rel; TIGR03056
398580010360	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
398580010361	MarR family; Region: MarR_2; pfam12802
398580010362	nitrilase; Region: PLN02798
398580010363	Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572
398580010364	putative active site [active]
398580010365	catalytic triad [active]
398580010366	dimer interface [polypeptide binding]; other site
398580010367	Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418
398580010368	GSH binding site [chemical binding]; other site
398580010369	catalytic residues [active]
398580010370	phytoene desaturase; Region: crtI_fam; TIGR02734
398580010371	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
398580010372	hydroxyglutarate oxidase; Provisional; Region: PRK11728
398580010373	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
398580010374	active site lid residues [active]
398580010375	substrate binding pocket [chemical binding]; other site
398580010376	catalytic residues [active]
398580010377	substrate-Mg2+ binding site; other site
398580010378	aspartate-rich region 1; other site
398580010379	aspartate-rich region 2; other site
398580010380	TspO/MBR family; Region: TspO_MBR; pfam03073
398580010381	Hydroxyneurosporene synthase (CrtC); Region: CrtC; pfam07143
398580010382	phytoene desaturase; Region: crtI_fam; TIGR02734
398580010383	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
398580010384	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
398580010385	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
398580010386	substrate binding pocket [chemical binding]; other site
398580010387	chain length determination region; other site
398580010388	substrate-Mg2+ binding site; other site
398580010389	catalytic residues [active]
398580010390	aspartate-rich region 1; other site
398580010391	active site lid residues [active]
398580010392	aspartate-rich region 2; other site
398580010393	C-20 methyltransferase BchU; Region: C20_methyl_CrtF; TIGR02716
398580010394	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
398580010395	S-adenosylmethionine binding site [chemical binding]; other site
398580010396	2-desacetyl-2-hydroxyethyl bacteriochlorophyllide A dehydrogenase; Region: bchC; TIGR01202
398580010397	2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255
398580010398	putative NAD(P) binding site [chemical binding]; other site
398580010399	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
398580010400	chlorophyllide reductase iron protein subunit X; Region: BchX; TIGR02016
398580010401	Chlide_reductase_Y : Y subunit of chlorophyllide (chlide) reductase (BchY).  Chlide reductase participates in photosynthetic pigment synthesis playing a role in the conversion of chlorophylls(Chl) into bacteriochlorophylls (BChl). Chlide reductase...; Region: Chlide_reductase_Y; cd01980
398580010402	chlorophyllide reductase subunit Y; Region: BchY; TIGR02015
398580010403	The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia.  This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775
398580010404	chlorophyllide reductase subunit Z; Region: BchZ; TIGR02014
398580010405	Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369
398580010406	PufQ cytochrome subunit; Region: PufQ; pfam05398
398580010407	Antenna complex alpha/beta subunit; Region: LHC; pfam00556
398580010408	Antenna complex alpha/beta subunit; Region: LHC; pfam00556
398580010409	Subunit L of bacterial photosynthetic reaction center; Region: Photo-RC_L; cd09290
398580010410	subunit M interface; other site
398580010411	subunit H interface; other site
398580010412	quinone binding site; other site
398580010413	bacteriopheophytin binding site; other site
398580010414	bacteriochlorophyll binding site; other site
398580010415	cytochrome C subunit interface; other site
398580010416	Fe binding site [ion binding]; other site
398580010417	photosynthetic reaction center subunit M; Provisional; Region: PRK14504
398580010418	pheophytin binding site; other site
398580010419	chlorophyll binding site; other site
398580010420	quinone binding site; other site
398580010421	Fe binding site [ion binding]; other site
398580010422	Cytochrome C subunit of the bacterial photosynthetic reaction center; Region: CytoC_RC; cd09224
398580010423	subunit interface [polypeptide binding]; other site
398580010424	Heme binding sites [chemical binding]; other site
398580010425	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK12571
398580010426	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
398580010427	TPP-binding site; other site
398580010428	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
398580010429	PYR/PP interface [polypeptide binding]; other site
398580010430	dimer interface [polypeptide binding]; other site
398580010431	TPP binding site [chemical binding]; other site
398580010432	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
398580010433	Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885
398580010434	isopentenyl-diphosphate delta-isomerase, type 1; Region: IPP_isom_1; TIGR02150
398580010435	active site
398580010436	metal binding site [ion binding]; metal-binding site
398580010437	nudix motif; other site
398580010438	geranylgeranyl reductase; Region: BchP-ChlP; TIGR02023
398580010439	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
398580010440	PUCC protein; Region: PUCC; pfam03209
398580010441	bacteriochlorophyll/chlorophyll a synthase; Reviewed; Region: PRK07566
398580010442	UbiA prenyltransferase family; Region: UbiA; pfam01040
398580010443	transcriptional regulator PpsR; Region: PpsR-CrtJ; TIGR02040
398580010444	PAS domain; Region: PAS; smart00091
398580010445	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
398580010446	putative active site [active]
398580010447	heme pocket [chemical binding]; other site
398580010448	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
398580010449	B12 binding domain; Region: B12-binding_2; pfam02607
398580010450	B12 binding domain; Region: B12-binding; pfam02310
398580010451	B12 binding site [chemical binding]; other site
398580010452	2-vinyl bacteriochlorophyllide hydratase (BCHF); Region: BCHF; pfam07284
398580010453	light-independent protochlorophyllide reductase subunit N; Provisional; Region: PRK02842
398580010454	light-independent protochlorophyllide reductase, N subunit; Region: DPOR_bchN; TIGR01279
398580010455	light-independent protochlorophyllide reductase subunit B; Provisional; Region: PRK02910
398580010456	Pchlide_reductase_B: B protein of the NB protein complex of Protochlorophyllide (Pchlide)_reductase. Pchlide reductase catalyzes the reductive formation of chlorophyllide (chlide) from protochlorophyllide (pchlide) during biosynthesis of chlorophylls and...; Region: Pchlide_reductase_B; cd01981
398580010457	Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369
398580010458	magnesium chelatase subunit H; Provisional; Region: bchH; PRK13405
398580010459	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
398580010460	protochlorophyllide reductase iron-sulfur ATP-binding protein; Provisional; Region: chlL; PRK13185
398580010461	This family of proteins contains bchL and chlL. Protochlorophyllide reductase catalyzes the reductive formation of chlorophyllide from protochlorophyllide during biosynthesis of chlorophylls and bacteriochlorophylls. Three genes, bchL, bchN and bchB, are...; Region: Bchl_like; cd02032
398580010462	P-loop; other site
398580010463	Mg-protoporphyrin IX methyl transferase; Validated; Region: PRK07580
398580010464	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
398580010465	S-adenosylmethionine binding site [chemical binding]; other site
398580010466	Magnesium-protoporphyrin IX methyltransferase C-terminus; Region: Mg-por_mtran_C; pfam07109
398580010467	PUCC protein; Region: PUCC; pfam03209
398580010468	photosynthetic reaction center, subunit H, bacterial; Region: puhA; TIGR01150
398580010469	Photosynthetic reaction center (RC) complex, subunit H;  RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl17581
398580010470	subunit M interaction residues [polypeptide binding]; other site
398580010471	subunit L interaction residues [polypeptide binding]; other site
398580010472	putative proton transfer pathway, P1; other site
398580010473	putative proton transfer pathway, P2; other site
398580010474	Bacterial PH domain; Region: DUF304; pfam03703
398580010475	putative photosynthetic complex assembly protein; Region: photo_alph_chp1; TIGR03054
398580010476	Aerobic Cyclase System Fe-containing subunit (ACSF), ferritin-like diiron-binding domain; Region: ACSF; cd01047
398580010477	diiron binding motif [ion binding]; other site
398580010478	Protein of unknown function (DUF3623); Region: DUF3623; pfam12291
398580010479	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
398580010480	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
398580010481	substrate-cofactor binding pocket; other site
398580010482	pyridoxal 5'-phosphate binding site [chemical binding]; other site
398580010483	catalytic residue [active]
398580010484	Cytochrome c; Region: Cytochrom_C; cl11414
398580010485	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
398580010486	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
398580010487	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
398580010488	Walker A/P-loop; other site
398580010489	ATP binding site [chemical binding]; other site
398580010490	Q-loop/lid; other site
398580010491	ABC transporter signature motif; other site
398580010492	Walker B; other site
398580010493	D-loop; other site
398580010494	H-loop/switch region; other site
398580010495	Glycerophosphodiester phosphodiesterase domain similar to Escherichia coli periplasmic phosphodiesterase (GlpQ) include uncharacterized proteins; Region: GDPD_EcGlpQ_like_1; cd08560
398580010496	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
398580010497	putative active site [active]
398580010498	catalytic site [active]
398580010499	putative metal binding site [ion binding]; other site
398580010500	bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134
398580010501	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
398580010502	S-adenosylmethionine binding site [chemical binding]; other site
398580010503	proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249
398580010504	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
398580010505	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
398580010506	acetyl-CoA synthetase; Provisional; Region: PRK00174
398580010507	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
398580010508	active site
398580010509	CoA binding site [chemical binding]; other site
398580010510	acyl-activating enzyme (AAE) consensus motif; other site
398580010511	AMP binding site [chemical binding]; other site
398580010512	acetate binding site [chemical binding]; other site
398580010513	adenylate kinase; Reviewed; Region: adk; PRK00279
398580010514	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
398580010515	AMP-binding site [chemical binding]; other site
398580010516	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
398580010517	Domain of unknown function (DUF4212); Region: DUF4212; pfam13937
398580010518	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
398580010519	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480
398580010520	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
398580010521	Na binding site [ion binding]; other site
398580010522	Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905
398580010523	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
398580010524	ligand binding site [chemical binding]; other site
398580010525	flexible hinge region; other site
398580010526	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800
398580010527	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
398580010528	metal binding triad; other site
398580010529	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
398580010530	active site
398580010531	catalytic site [active]
398580010532	substrate binding site [chemical binding]; other site
398580010533	ribosome maturation protein RimP; Reviewed; Region: PRK00092
398580010534	Sm and related proteins; Region: Sm_like; cl00259
398580010535	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
398580010536	putative oligomer interface [polypeptide binding]; other site
398580010537	putative RNA binding site [nucleotide binding]; other site
398580010538	transcription elongation factor NusA; Validated; Region: nusA; PRK09202
398580010539	NusA N-terminal domain; Region: NusA_N; pfam08529
398580010540	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
398580010541	RNA binding site [nucleotide binding]; other site
398580010542	homodimer interface [polypeptide binding]; other site
398580010543	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
398580010544	G-X-X-G motif; other site
398580010545	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
398580010546	G-X-X-G motif; other site
398580010547	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
398580010548	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
398580010549	hypothetical protein; Provisional; Region: PRK09190
398580010550	Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279
398580010551	putative RNA binding cleft [nucleotide binding]; other site
398580010552	Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364
398580010553	translation initiation factor IF-2; Region: IF-2; TIGR00487
398580010554	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
398580010555	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
398580010556	G1 box; other site
398580010557	putative GEF interaction site [polypeptide binding]; other site
398580010558	GTP/Mg2+ binding site [chemical binding]; other site
398580010559	Switch I region; other site
398580010560	G2 box; other site
398580010561	G3 box; other site
398580010562	Switch II region; other site
398580010563	G4 box; other site
398580010564	G5 box; other site
398580010565	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
398580010566	Translation-initiation factor 2; Region: IF-2; pfam11987
398580010567	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
398580010568	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
398580010569	active site
398580010570	8-oxo-dGMP binding site [chemical binding]; other site
398580010571	nudix motif; other site
398580010572	metal binding site [ion binding]; metal-binding site
398580010573	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
398580010574	heterotetramer interface [polypeptide binding]; other site
398580010575	active site pocket [active]
398580010576	cleavage site
398580010577	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
398580010578	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
398580010579	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
398580010580	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
398580010581	nucleotide binding region [chemical binding]; other site
398580010582	ATP-binding site [chemical binding]; other site
398580010583	SEC-C motif; Region: SEC-C; pfam02810
398580010584	PBP superfamily domain; Region: PBP_like_2; cl17296
398580010585	hypothetical protein; Reviewed; Region: PRK00024
398580010586	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
398580010587	MPN+ (JAMM) motif; other site
398580010588	Zinc-binding site [ion binding]; other site
398580010589	chaperone protein DnaJ; Provisional; Region: PRK10767
398580010590	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
398580010591	HSP70 interaction site [polypeptide binding]; other site
398580010592	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
398580010593	substrate binding site [polypeptide binding]; other site
398580010594	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
398580010595	Zn binding sites [ion binding]; other site
398580010596	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
398580010597	dimer interface [polypeptide binding]; other site
398580010598	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
398580010599	Nucleotide-binding domain of human HSPA9, Escherichia coli DnaK, and similar proteins; Region: HSPA9-like_NBD; cd11733
398580010600	nucleotide binding site [chemical binding]; other site
398580010601	NEF interaction site [polypeptide binding]; other site
398580010602	SBD interface [polypeptide binding]; other site
398580010603	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532
398580010604	ABC-2 type transporter; Region: ABC2_membrane; cl17235
398580010605	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
398580010606	active site
398580010607	3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450
398580010608	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
398580010609	Ligand binding site; other site
398580010610	oligomer interface; other site
398580010611	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
398580010612	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
398580010613	active site
398580010614	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
398580010615	active site
398580010616	tetramer interface; other site
398580010617	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
398580010618	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
398580010619	Glycosyl transferase family 2; Region: Glyco_tranf_2_4; pfam13704
398580010620	Core-2/I-Branching enzyme; Region: Branch; pfam02485
398580010621	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
398580010622	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
398580010623	active site
398580010624	phosphorylation site [posttranslational modification]
398580010625	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
398580010626	30S subunit binding site; other site
398580010627	RNA polymerase sigma-54 factor; Region: rpoN_sigma; TIGR02395
398580010628	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
398580010629	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
398580010630	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
398580010631	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
398580010632	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
398580010633	Walker A/P-loop; other site
398580010634	ATP binding site [chemical binding]; other site
398580010635	Q-loop/lid; other site
398580010636	ABC transporter signature motif; other site
398580010637	Walker B; other site
398580010638	D-loop; other site
398580010639	H-loop/switch region; other site
398580010640	lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002
398580010641	OstA-like protein; Region: OstA; pfam03968
398580010642	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5375
398580010643	D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892
398580010644	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
398580010645	putative active site [active]
398580010646	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
398580010647	Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349
398580010648	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
398580010649	catalytic site [active]
398580010650	putative active site [active]
398580010651	putative substrate binding site [chemical binding]; other site
398580010652	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
398580010653	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271
398580010654	putative NAD(P) binding site [chemical binding]; other site
398580010655	active site
398580010656	exosortase/archaeosortase family protein; Region: exo_archaeo; TIGR04178
398580010657	CAAX protease self-immunity; Region: Abi; cl00558
398580010658	Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086
398580010659	putative metal binding site [ion binding]; other site
398580010660	Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304
398580010661	Ca2+ binding site [ion binding]; other site
398580010662	Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086
398580010663	putative metal binding site [ion binding]; other site
398580010664	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
398580010665	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
398580010666	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
398580010667	Cna protein B-type domain; Region: Cna_B; pfam05738
398580010668	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
398580010669	Domain of unknown function (DUF305); Region: DUF305; cl17794
398580010670	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
398580010671	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
398580010672	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
398580010673	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
398580010674	Multicopper oxidase; Region: Cu-oxidase; pfam00394
398580010675	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
398580010676	Disulfide bond formation protein DsbB; Region: DsbB; pfam02600
398580010677	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
398580010678	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
398580010679	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302
398580010680	EF-hand domain pair; Region: EF_hand_5; pfam13499
398580010681	Ca2+ binding site [ion binding]; other site
398580010682	Domain of unknown function DUF302; Region: DUF302; pfam03625
398580010683	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
398580010684	copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511
398580010685	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
398580010686	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
398580010687	motif II; other site
398580010688	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
398580010689	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683
398580010690	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
398580010691	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
398580010692	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
398580010693	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
398580010694	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
398580010695	haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710
398580010696	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
398580010697	dimerization interface [polypeptide binding]; other site
398580010698	putative Zn2+ binding site [ion binding]; other site
398580010699	putative DNA binding site [nucleotide binding]; other site
398580010700	Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529
398580010701	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
398580010702	apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302
398580010703	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
398580010704	putative active site [active]
398580010705	catalytic triad [active]
398580010706	putative dimer interface [polypeptide binding]; other site
398580010707	Signal peptidase (SPase) II; Region: Peptidase_A8; pfam01252
398580010708	lipoprotein signal peptidase; Provisional; Region: PRK14787
398580010709	ZIP Zinc transporter; Region: Zip; pfam02535
398580010710	Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428
398580010711	Protein of unknown function, DUF; Region: DUF411; cl01142
398580010712	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
398580010713	Peptidase family M23; Region: Peptidase_M23; pfam01551
398580010714	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
398580010715	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
398580010716	Cu(I) binding site [ion binding]; other site
398580010717	Protein of unknown function (DUF461); Region: DUF461; pfam04314
398580010718	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
398580010719	Thioredoxin; Region: Thioredoxin_4; pfam13462
398580010720	Disulfide bond formation protein DsbB; Region: DsbB; cl00649
398580010721	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
398580010722	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
398580010723	Cu(I) binding site [ion binding]; other site
398580010724	zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514
398580010725	Helix-Turn-Helix DNA binding domain of the CadR- and PbrR-like transcription regulators; Region: HTH_CadR-PbrR-like; cd04785
398580010726	DNA binding residues [nucleotide binding]
398580010727	dimer interface [polypeptide binding]; other site
398580010728	putative metal binding site [ion binding]; other site
398580010729	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
398580010730	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
398580010731	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
398580010732	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
398580010733	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
398580010734	Protein of unknown function (DUF3478); Region: DUF3478; pfam11964
398580010735	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
398580010736	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
398580010737	active site
398580010738	DNA binding site [nucleotide binding]
398580010739	Int/Topo IB signature motif; other site
398580010740	Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319
398580010741	Putative transposase; Region: Y2_Tnp; pfam04986
398580010742	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
398580010743	AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136
398580010744	conserved cys residue [active]
398580010745	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
398580010746	CoA-transferase family III; Region: CoA_transf_3; pfam02515
398580010747	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
398580010748	CoA-transferase family III; Region: CoA_transf_3; pfam02515
398580010749	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
398580010750	non-specific DNA binding site [nucleotide binding]; other site
398580010751	salt bridge; other site
398580010752	sequence-specific DNA binding site [nucleotide binding]; other site
398580010753	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
398580010754	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
398580010755	N-acetyl-D-glucosamine binding site [chemical binding]; other site
398580010756	catalytic residue [active]
398580010757	TrbC/VIRB2 family; Region: TrbC; pfam04956
398580010758	Type IV secretory pathway, VirB3-like protein; Region: VirB3; cl01501
398580010759	type IV secretion/conjugal transfer ATPase, VirB4 family; Region: VirB4_CagE; TIGR00929
398580010760	CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135
398580010761	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
398580010762	Walker A motif; other site
398580010763	ATP binding site [chemical binding]; other site
398580010764	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
398580010765	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
398580010766	N-acetyl-D-glucosamine binding site [chemical binding]; other site
398580010767	catalytic residue [active]
398580010768	P-type DNA transfer protein VirB5; Region: VirB5; TIGR02791
398580010769	Type IV secretion system proteins; Region: T4SS; pfam07996
398580010770	VirB8 protein; Region: VirB8; pfam04335
398580010771	VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cl11423
398580010772	VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911
398580010773	VirB7 interaction site; other site
398580010774	Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743
398580010775	P-type DNA transfer ATPase VirB11; Region: VirB11; TIGR02788
398580010776	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
398580010777	Walker A motif; other site
398580010778	hexamer interface [polypeptide binding]; other site
398580010779	ATP binding site [chemical binding]; other site
398580010780	Walker B motif; other site
398580010781	Domain of unknown function (DUF4177); Region: DUF4177; pfam13783
398580010782	TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; pfam04610
398580010783	Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cl02626
398580010784	active site
398580010785	DNA binding site [nucleotide binding]
398580010786	catalytic site [active]
398580010787	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
398580010788	RT_Bac_retron_I: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_I; cd01646
398580010789	putative active site [active]
398580010790	putative NTP binding site [chemical binding]; other site
398580010791	putative nucleic acid binding site [nucleotide binding]; other site
398580010792	Type IV secretory system Conjugative DNA transfer; Region: T4SS-DNA_transf; pfam02534
398580010793	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
398580010794	Walker A motif; other site
398580010795	ATP binding site [chemical binding]; other site
398580010796	Walker B motif; other site
398580010797	type IV secretion system T-DNA border endonuclease VirD2; Provisional; Region: PRK13863
398580010798	Helix-turn-helix domain; Region: HTH_38; pfam13936
398580010799	Protein of unknown function (DUF2493); Region: DUF2493; pfam10686
398580010800	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
398580010801	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
398580010802	active site
398580010803	DNA binding site [nucleotide binding]
398580010804	Int/Topo IB signature motif; other site
398580010805	Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319
398580010806	Putative transposase; Region: Y2_Tnp; pfam04986
398580010807	Predicted membrane protein [Function unknown]; Region: COG3174
398580010808	Domain of unknown function (DUF4010); Region: DUF4010; pfam13194
398580010809	Protein of unknown function (DUF3018); Region: DUF3018; pfam11455
398580010810	PemK-like protein; Region: PemK; pfam02452
398580010811	Transcription factor zinc-finger; Region: zf-TFIIB; cl01565
398580010812	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
398580010813	Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432
398580010814	Exopolysaccharide synthesis, ExoD; Region: ExoD; pfam06055
398580010815	K+-dependent Na+/Ca+ exchanger related-protein; Region: TIGR00367
398580010816	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
398580010817	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
398580010818	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
398580010819	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
398580010820	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
398580010821	Domain of unknown function DUF21; Region: DUF21; pfam01595
398580010822	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
398580010823	Transporter associated domain; Region: CorC_HlyC; smart01091
398580010824	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
398580010825	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
398580010826	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
398580010827	ligand binding site [chemical binding]; other site
398580010828	flexible hinge region; other site
398580010829	Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526
398580010830	Domain of unknown function (DUF4158); Region: DUF4158; pfam13700
398580010831	AAA domain; Region: AAA_22; pfam13401
398580010832	Winged helix-turn helix; Region: HTH_29; pfam13551
398580010833	Helix-turn-helix domain; Region: HTH_28; pfam13518
398580010834	Homeodomain-like domain; Region: HTH_32; pfam13565
398580010835	Integrase core domain; Region: rve; pfam00665
398580010836	Integrase core domain; Region: rve_3; cl15866
398580010837	Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299
398580010838	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
398580010839	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
398580010840	catalytic residues [active]
398580010841	catalytic nucleophile [active]
398580010842	Presynaptic Site I dimer interface [polypeptide binding]; other site
398580010843	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
398580010844	Synaptic Flat tetramer interface [polypeptide binding]; other site
398580010845	Synaptic Site I dimer interface [polypeptide binding]; other site
398580010846	DNA binding site [nucleotide binding]
398580010847	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
398580010848	DNA-binding interface [nucleotide binding]; DNA binding site
398580010849	thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284
398580010850	ThiC-associated domain; Region: ThiC-associated; pfam13667
398580010851	Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422
398580010852	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
398580010853	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
398580010854	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
398580010855	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
398580010856	catalytic residues [active]
398580010857	catalytic nucleophile [active]
398580010858	Presynaptic Site I dimer interface [polypeptide binding]; other site
398580010859	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
398580010860	Synaptic Flat tetramer interface [polypeptide binding]; other site
398580010861	Synaptic Site I dimer interface [polypeptide binding]; other site
398580010862	DNA binding site [nucleotide binding]
398580010863	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
398580010864	DNA-binding interface [nucleotide binding]; DNA binding site
398580010865	BioY family; Region: BioY; pfam02632
398580010866	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
398580010867	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
398580010868	Walker A/P-loop; other site
398580010869	ATP binding site [chemical binding]; other site
398580010870	Q-loop/lid; other site
398580010871	ABC transporter signature motif; other site
398580010872	Walker B; other site
398580010873	D-loop; other site
398580010874	H-loop/switch region; other site
398580010875	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
398580010876	BioY family; Region: BioY; pfam02632
398580010877	Protein of unknown function (DUF736); Region: DUF736; pfam05284
398580010878	Protein of unknown function (DUF736); Region: DUF736; pfam05284
398580010879	Helicase_C-like; Region: Helicase_C_4; pfam13871
398580010880	AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287
398580010881	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
398580010882	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
398580010883	ATP binding site [chemical binding]; other site
398580010884	putative Mg++ binding site [ion binding]; other site
398580010885	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
398580010886	nucleotide binding region [chemical binding]; other site
398580010887	ATP-binding site [chemical binding]; other site
398580010888	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
398580010889	INT_SG5, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 5, N- and C-terminal domains. The CD contains mainly predicted bacterial integrase/recombinases; Region: INT_SG5; cd01190
398580010890	Int/Topo IB signature motif; other site
398580010891	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
398580010892	active site
398580010893	DNA binding site [nucleotide binding]
398580010894	Int/Topo IB signature motif; other site
398580010895	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
398580010896	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235
398580010897	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
398580010898	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
398580010899	active site
398580010900	DNA binding site [nucleotide binding]
398580010901	Int/Topo IB signature motif; other site
398580010902	Methyltransferase domain; Region: Methyltransf_26; pfam13659
398580010903	P-loop containing NTP hydrolase pore-1; Region: AAA_34; pfam13872
398580010904	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
398580010905	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
398580010906	active site
398580010907	DNA binding site [nucleotide binding]
398580010908	Int/Topo IB signature motif; other site
398580010909	Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319
398580010910	Putative transposase; Region: Y2_Tnp; pfam04986
398580010911	putative transposase OrfB; Reviewed; Region: PHA02517
398580010912	HTH-like domain; Region: HTH_21; pfam13276
398580010913	Integrase core domain; Region: rve; pfam00665
398580010914	Integrase core domain; Region: rve_3; cl15866
398580010915	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
398580010916	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
398580010917	Helix-turn-helix domain; Region: HTH_18; pfam12833
398580010918	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
398580010919	DctM-like transporters; Region: DctM; pfam06808
398580010920	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
398580010921	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
398580010922	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
398580010923	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
398580010924	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
398580010925	classical (c) SDRs; Region: SDR_c; cd05233
398580010926	NAD(P) binding site [chemical binding]; other site
398580010927	active site
398580010928	Protein of unknown function (DUF2390); Region: DUF2390; pfam09523
398580010929	3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163
398580010930	Flavoprotein; Region: Flavoprotein; pfam02441
398580010931	Transcriptional regulator [Transcription]; Region: LysR; COG0583
398580010932	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
398580010933	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
398580010934	dimerization interface [polypeptide binding]; other site
398580010935	3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; pfam01977
398580010936	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
398580010937	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
398580010938	NAD(P) binding site [chemical binding]; other site
398580010939	catalytic residues [active]
398580010940	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
398580010941	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
398580010942	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
398580010943	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
398580010944	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
398580010945	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
398580010946	Carbon monoxide dehydrogenase subunit G (CoxG); Region: CoxG; cd05018
398580010947	putative hydrophobic ligand binding site [chemical binding]; other site
398580010948	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
398580010949	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092
398580010950	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
398580010951	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
398580010952	catalytic loop [active]
398580010953	iron binding site [ion binding]; other site
398580010954	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
398580010955	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
398580010956	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
398580010957	Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929
398580010958	acyl-activating enzyme (AAE) consensus motif; other site
398580010959	acyl-activating enzyme (AAE) consensus motif; other site
398580010960	putative AMP binding site [chemical binding]; other site
398580010961	putative active site [active]
398580010962	putative CoA binding site [chemical binding]; other site
398580010963	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
398580010964	enoyl-CoA hydratase; Provisional; Region: PRK06688
398580010965	substrate binding site [chemical binding]; other site
398580010966	oxyanion hole (OAH) forming residues; other site
398580010967	trimer interface [polypeptide binding]; other site
398580010968	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
398580010969	Periplasmic solute-binding domain of active transport proteins; Region: PBP1_SBP_like_3; cd06329
398580010970	putative ligand binding site [chemical binding]; other site
398580010971	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
398580010972	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
398580010973	TM-ABC transporter signature motif; other site
398580010974	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
398580010975	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
398580010976	TM-ABC transporter signature motif; other site
398580010977	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
398580010978	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
398580010979	Walker A/P-loop; other site
398580010980	ATP binding site [chemical binding]; other site
398580010981	Q-loop/lid; other site
398580010982	ABC transporter signature motif; other site
398580010983	Walker B; other site
398580010984	D-loop; other site
398580010985	H-loop/switch region; other site
398580010986	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
398580010987	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
398580010988	Walker A/P-loop; other site
398580010989	ATP binding site [chemical binding]; other site
398580010990	Q-loop/lid; other site
398580010991	ABC transporter signature motif; other site
398580010992	Walker B; other site
398580010993	D-loop; other site
398580010994	H-loop/switch region; other site
398580010995	Toxin with endonuclease activity YhaV; Region: Toxin_YhaV; pfam11663
398580010996	putative regulator PrlF; Provisional; Region: PRK09974
398580010997	Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002
398580010998	ParB-like nuclease domain; Region: ParB; smart00470
398580010999	Transposase; Region: DEDD_Tnp_IS110; pfam01548
398580011000	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
398580011001	putative transposase OrfB; Reviewed; Region: PHA02517
398580011002	HTH-like domain; Region: HTH_21; pfam13276
398580011003	Integrase core domain; Region: rve; pfam00665
398580011004	Integrase core domain; Region: rve_3; cl15866
398580011005	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116
398580011006	Transposase; Region: DEDD_Tnp_IS110; pfam01548
398580011007	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
398580011008	putative transposase OrfB; Reviewed; Region: PHA02517
398580011009	Integrase core domain; Region: rve; pfam00665
398580011010	Integrase core domain; Region: rve_3; pfam13683
398580011011	Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227
398580011012	Domain of unknown function (DUF1738); Region: DUF1738; pfam08401
398580011013	Replication protein C N-terminal domain; Region: RP-C; pfam03428
398580011014	Replication protein C C-terminal region; Region: RP-C_C; pfam11800
398580011015	ParB-like nuclease domain; Region: ParBc; cl02129
398580011016	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
398580011017	plasmid partitioning protein RepA; Region: partition_RepA; TIGR03453
398580011018	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
398580011019	P-loop; other site
398580011020	Magnesium ion binding site [ion binding]; other site
398580011021	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
398580011022	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
398580011023	Walker A motif; other site
398580011024	ATP binding site [chemical binding]; other site
398580011025	Walker B motif; other site
398580011026	arginine finger; other site
398580011027	Domain of unknown function (DUF4143); Region: DUF4143; pfam13635
398580011028	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
398580011029	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
398580011030	catalytic residues [active]
398580011031	catalytic nucleophile [active]
398580011032	Presynaptic Site I dimer interface [polypeptide binding]; other site
398580011033	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
398580011034	Synaptic Flat tetramer interface [polypeptide binding]; other site
398580011035	Synaptic Site I dimer interface [polypeptide binding]; other site
398580011036	DNA binding site [nucleotide binding]
398580011037	putative addiction module antidote protein, CC2985 family; Region: antidote_CC2985; TIGR02606
398580011038	Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668
398580011039	Cre recombinase, C-terminal catalytic domain. Cre-like recombinases belong to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The bacteriophage P1 Cre...; Region: INT_Cre; cd00799
398580011040	DNA binding site [nucleotide binding]
398580011041	dimer interface [polypeptide binding]; other site
398580011042	Int/Topo IB signature motif; other site
398580011043	active site
398580011044	Protein of unknown function (DUF1403); Region: DUF1403; pfam07183
398580011045	Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079
398580011046	WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996
398580011047	Fic family protein [Function unknown]; Region: COG3177
398580011048	Domain of unknown function (DUF4172); Region: DUF4172; pfam13776
398580011049	Fic/DOC family; Region: Fic; pfam02661
398580011050	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
398580011051	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
398580011052	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
398580011053	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
398580011054	Transposase; Region: DEDD_Tnp_IS110; pfam01548
398580011055	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
398580011056	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
398580011057	Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal; Region: UCR_Fe-S_N; pfam10399
398580011058	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
398580011059	Homeodomain-like domain; Region: HTH_23; cl17451
398580011060	DDE superfamily endonuclease; Region: DDE_3; pfam13358
398580011061	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
398580011062	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
398580011063	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
398580011064	ligand binding site [chemical binding]; other site
398580011065	Protein of unknown function, DUF; Region: DUF411; cl01142
398580011066	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
398580011067	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
398580011068	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
398580011069	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
398580011070	Uncharacterized conserved protein [Function unknown]; Region: COG0398
398580011071	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
398580011072	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: PspE; COG0607
398580011073	active site residue [active]
398580011074	osmolarity response regulator; Provisional; Region: ompR; PRK09468
398580011075	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
398580011076	active site
398580011077	phosphorylation site [posttranslational modification]
398580011078	intermolecular recognition site; other site
398580011079	dimerization interface [polypeptide binding]; other site
398580011080	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
398580011081	DNA binding site [nucleotide binding]
398580011082	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
398580011083	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
398580011084	dimerization interface [polypeptide binding]; other site
398580011085	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
398580011086	dimer interface [polypeptide binding]; other site
398580011087	phosphorylation site [posttranslational modification]
398580011088	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
398580011089	ATP binding site [chemical binding]; other site
398580011090	Mg2+ binding site [ion binding]; other site
398580011091	G-X-G motif; other site
398580011092	Predicted membrane protein [Function unknown]; Region: COG3462
398580011093	Short C-terminal domain; Region: SHOCT; pfam09851
398580011094	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138
398580011095	periplasmic protein thiol:disulfide oxidoreductases, DsbE subfamily; Region: dsbE; TIGR00385
398580011096	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
398580011097	Cytochrome C biogenesis protein; Region: CcmH; pfam03918
398580011098	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235
398580011099	cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142
398580011100	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
398580011101	Disulphide bond corrector protein DsbC; Region: DsbC; cl15830
398580011102	Thiol:disulfide interchange protein [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4232
398580011103	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
398580011104	DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953
398580011105	DsbD alpha interface [polypeptide binding]; other site
398580011106	catalytic residues [active]
398580011107	Predicted membrane protein [Function unknown]; Region: COG1288; cl17886
398580011108	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
398580011109	Cytochrome c; Region: Cytochrom_C; pfam00034
398580011110	Cytochrome C' Region: Cytochrom_C_2; pfam01322
398580011111	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
398580011112	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
398580011113	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
398580011114	Multicopper oxidase; Region: Cu-oxidase; pfam00394
398580011115	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
398580011116	Cytochrome c; Region: Cytochrom_C; pfam00034
398580011117	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
398580011118	DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023
398580011119	catalytic residues [active]
398580011120	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
398580011121	metal-binding site [ion binding]
398580011122	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
398580011123	metal-binding site [ion binding]
398580011124	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
398580011125	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
398580011126	metal-binding site [ion binding]
398580011127	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
398580011128	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
398580011129	motif II; other site
398580011130	Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044
398580011131	Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108
398580011132	DNA binding residues [nucleotide binding]
398580011133	dimer interface [polypeptide binding]; other site
398580011134	copper binding site [ion binding]; other site
398580011135	Glutaredoxin and related proteins [Posttranslational modification, protein turnover, chaperones]; Region: GrxC; COG0695
398580011136	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
398580011137	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_8; cd08495
398580011138	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
398580011139	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
398580011140	dimer interface [polypeptide binding]; other site
398580011141	conserved gate region; other site
398580011142	putative PBP binding loops; other site
398580011143	ABC-ATPase subunit interface; other site
398580011144	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
398580011145	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
398580011146	dimer interface [polypeptide binding]; other site
398580011147	ABC-ATPase subunit interface; other site
398580011148	putative PBP binding loops; other site
398580011149	ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608
398580011150	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
398580011151	Walker A/P-loop; other site
398580011152	ATP binding site [chemical binding]; other site
398580011153	Q-loop/lid; other site
398580011154	ABC transporter signature motif; other site
398580011155	Walker B; other site
398580011156	D-loop; other site
398580011157	H-loop/switch region; other site
398580011158	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
398580011159	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
398580011160	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
398580011161	Walker A/P-loop; other site
398580011162	ATP binding site [chemical binding]; other site
398580011163	Q-loop/lid; other site
398580011164	ABC transporter signature motif; other site
398580011165	Walker B; other site
398580011166	D-loop; other site
398580011167	H-loop/switch region; other site
398580011168	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
398580011169	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
398580011170	Complex I intermediate-associated protein 30 (CIA30); Region: CIA30; pfam08547
398580011171	HupE / UreJ protein; Region: HupE_UreJ; pfam04955
398580011172	catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061
398580011173	Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196
398580011174	heme binding site [chemical binding]; other site
398580011175	C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200
398580011176	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
398580011177	DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151
398580011178	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
398580011179	dimerization interface [polypeptide binding]; other site
398580011180	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
398580011181	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
398580011182	DNA binding residues [nucleotide binding]
398580011183	dimerization interface [polypeptide binding]; other site
398580011184	putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12648
398580011185	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
398580011186	Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111
398580011187	Domain of unknown function (DUF4040); Region: DUF4040; cl00676
398580011188	Domain of unknown function (DUF4040); Region: DUF4040; cl00676
398580011189	putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK09094
398580011190	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12666
398580011191	putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965
398580011192	putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK06161
398580011193	putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674
398580011194	fumarylacetoacetase; Region: PLN02856
398580011195	Domain of unknown function (DUF1969); Region: DUF1969; pfam09298
398580011196	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
398580011197	homogentisate 1,2-dioxygenase; Provisional; Region: PRK05341
398580011198	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
398580011199	MarR family; Region: MarR_2; pfam12802
398580011200	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
398580011201	FAD-dependent oxidoreductase; Provisional; Region: PRK08132
398580011202	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
398580011203	Protein of unknown function (DUF2783); Region: DUF2783; pfam10932
398580011204	beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050
398580011205	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
398580011206	dimer interface [polypeptide binding]; other site
398580011207	active site
398580011208	phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778
398580011209	phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156
398580011210	phenylacetate-CoA oxygenase subunit PaaB; Provisional; Region: paaB; PRK13781
398580011211	Phenylacetic acid catabolic protein; Region: PaaA_PaaC; pfam05138
398580011212	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
398580011213	phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159
398580011214	phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160
398580011215	NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214
398580011216	FAD binding pocket [chemical binding]; other site
398580011217	FAD binding motif [chemical binding]; other site
398580011218	phosphate binding motif [ion binding]; other site
398580011219	beta-alpha-beta structure motif; other site
398580011220	NAD(p) ribose binding residues [chemical binding]; other site
398580011221	NAD binding pocket [chemical binding]; other site
398580011222	NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site
398580011223	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
398580011224	catalytic loop [active]
398580011225	iron binding site [ion binding]; other site
398580011226	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
398580011227	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
398580011228	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
398580011229	phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155
398580011230	acyl-activating enzyme (AAE) consensus motif; other site
398580011231	AMP binding site [chemical binding]; other site
398580011232	active site
398580011233	CoA binding site [chemical binding]; other site
398580011234	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
398580011235	CoenzymeA binding site [chemical binding]; other site
398580011236	subunit interaction site [polypeptide binding]; other site
398580011237	PHB binding site; other site
398580011238	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
398580011239	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
398580011240	substrate binding site [chemical binding]; other site
398580011241	oxyanion hole (OAH) forming residues; other site
398580011242	trimer interface [polypeptide binding]; other site
398580011243	3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250
398580011244	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
398580011245	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
398580011246	bifunctional aldehyde dehydrogenase/enoyl-CoA hydratase; Provisional; Region: PRK11563
398580011247	N-terminal domain of the monoamine oxidase C dehydratase; Region: ALDH_MaoC-N; cd07128
398580011248	substrate binding site [chemical binding]; other site
398580011249	dimer interface [polypeptide binding]; other site
398580011250	NADP binding site [chemical binding]; other site
398580011251	catalytic residues [active]
398580011252	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
398580011253	active site 2 [active]
398580011254	active site 1 [active]
398580011255	PaaX-like protein; Region: PaaX; pfam07848
398580011256	PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223
398580011257	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
398580011258	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
398580011259	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
398580011260	Sucrose-6F-phosphate phosphohydrolase; Region: S6PP; pfam05116
398580011261	Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788
398580011262	glucosylglycerol-phosphate synthase; Region: gluc_glyc_Psyn; TIGR02398
398580011263	active site
398580011264	homotetramer interface [polypeptide binding]; other site
398580011265	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
398580011266	putative active site [active]
398580011267	catalytic site [active]
398580011268	Catalytic domain, repeat 2, of vertebrate phospholipases, PLD1 and PLD2, and similar proteins; Region: PLDc_vPLD1_2_like_2; cd09105
398580011269	PLD-like domain; Region: PLDc_2; pfam13091
398580011270	putative active site [active]
398580011271	catalytic site [active]
398580011272	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
398580011273	Histidine kinase; Region: HisKA_2; pfam07568
398580011274	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
398580011275	ATP binding site [chemical binding]; other site
398580011276	Mg2+ binding site [ion binding]; other site
398580011277	G-X-G motif; other site
398580011278	RNA polymerase sigma factor; Provisional; Region: PRK12546
398580011279	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
398580011280	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
398580011281	DNA binding residues [nucleotide binding]
398580011282	two-component response regulator; Provisional; Region: PRK09191
398580011283	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
398580011284	active site
398580011285	phosphorylation site [posttranslational modification]
398580011286	intermolecular recognition site; other site
398580011287	dimerization interface [polypeptide binding]; other site
398580011288	Domain of unknown function (DUF4157); Region: DUF4157; pfam13699
398580011289	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
398580011290	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
398580011291	dimerization interface [polypeptide binding]; other site
398580011292	DPS ferroxidase diiron center [ion binding]; other site
398580011293	ion pore; other site
398580011294	acetolactate synthase; Reviewed; Region: PRK08322
398580011295	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
398580011296	PYR/PP interface [polypeptide binding]; other site
398580011297	dimer interface [polypeptide binding]; other site
398580011298	TPP binding site [chemical binding]; other site
398580011299	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
398580011300	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
398580011301	TPP-binding site [chemical binding]; other site
398580011302	glutamate dehydrogenase; Provisional; Region: PRK09414
398580011303	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
398580011304	NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226
398580011305	NAD(P) binding pocket [chemical binding]; other site
398580011306	Small integral membrane protein [Function unknown]; Region: COG5487; cl17674
398580011307	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
398580011308	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
398580011309	ligand binding site [chemical binding]; other site
398580011310	flexible hinge region; other site
398580011311	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
398580011312	non-specific DNA interactions [nucleotide binding]; other site
398580011313	DNA binding site [nucleotide binding]
398580011314	sequence specific DNA binding site [nucleotide binding]; other site
398580011315	putative cAMP binding site [chemical binding]; other site
398580011316	plasmid partitioning protein RepB; Region: partition_RepB; TIGR03454
398580011317	ParB-like nuclease domain; Region: ParBc; pfam02195
398580011318	Rho termination factor, N-terminal domain; Region: Rho_N; cl06505
398580011319	TrkA-C domain; Region: TrkA_C; pfam02080
398580011320	HTH DNA binding domain; Region: HTH_13; pfam11972
398580011321	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
398580011322	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
398580011323	catalytic residues [active]
398580011324	catalytic nucleophile [active]
398580011325	Presynaptic Site I dimer interface [polypeptide binding]; other site
398580011326	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
398580011327	Synaptic Flat tetramer interface [polypeptide binding]; other site
398580011328	Synaptic Site I dimer interface [polypeptide binding]; other site
398580011329	DNA binding site [nucleotide binding]
398580011330	Replication initiator protein A; Region: RPA; pfam10134
398580011331	plasmid partitioning protein RepA; Region: partition_RepA; TIGR03453
398580011332	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
398580011333	P-loop; other site
398580011334	Magnesium ion binding site [ion binding]; other site
398580011335	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
398580011336	Magnesium ion binding site [ion binding]; other site
398580011337	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
398580011338	ParB-like nuclease domain; Region: ParBc; cl02129
398580011339	Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086
398580011340	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
398580011341	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
398580011342	NAD(P) binding site [chemical binding]; other site
398580011343	homodimer interface [polypeptide binding]; other site
398580011344	substrate binding site [chemical binding]; other site
398580011345	active site
398580011346	Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082
398580011347	Protein of unknown function (DUF2886); Region: DUF2886; pfam11102
398580011348	UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057
398580011349	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
398580011350	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
398580011351	Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940
398580011352	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230
398580011353	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230
398580011354	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
398580011355	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
398580011356	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
398580011357	This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799
398580011358	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
398580011359	putative ADP-binding pocket [chemical binding]; other site
398580011360	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
398580011361	active site
398580011362	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
398580011363	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
398580011364	NAD binding site [chemical binding]; other site
398580011365	homodimer interface [polypeptide binding]; other site
398580011366	active site
398580011367	substrate binding site [chemical binding]; other site
398580011368	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230
398580011369	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
398580011370	active site
398580011371	substrate binding sites [chemical binding]; other site
398580011372	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
398580011373	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
398580011374	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
398580011375	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
398580011376	AAA domain; Region: AAA_22; pfam13401
398580011377	Winged helix-turn helix; Region: HTH_29; pfam13551
398580011378	Helix-turn-helix domain; Region: HTH_28; pfam13518
398580011379	Homeodomain-like domain; Region: HTH_32; pfam13565
398580011380	Integrase core domain; Region: rve; pfam00665
398580011381	Integrase core domain; Region: rve_3; cl15866
398580011382	Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299
398580011383	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
398580011384	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
398580011385	catalytic residues [active]
398580011386	catalytic nucleophile [active]
398580011387	Presynaptic Site I dimer interface [polypeptide binding]; other site
398580011388	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
398580011389	Synaptic Flat tetramer interface [polypeptide binding]; other site
398580011390	Synaptic Site I dimer interface [polypeptide binding]; other site
398580011391	DNA binding site [nucleotide binding]
398580011392	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
398580011393	DNA-binding interface [nucleotide binding]; DNA binding site
398580011394	thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284
398580011395	ThiC-associated domain; Region: ThiC-associated; pfam13667
398580011396	Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422
398580011397	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
398580011398	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
398580011399	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
398580011400	DDE domain; Region: DDE_Tnp_IS240; pfam13610
398580011401	Integrase core domain; Region: rve; pfam00665
398580011402	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
398580011403	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
398580011404	putative efflux protein, MATE family; Region: matE; TIGR00797
398580011405	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
398580011406	putative active site [active]
398580011407	catalytic site [active]
398580011408	Catalytic domain, repeat 2, of vertebrate phospholipases, PLD1 and PLD2, and similar proteins; Region: PLDc_vPLD1_2_like_2; cd09105
398580011409	PLD-like domain; Region: PLDc_2; pfam13091
398580011410	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
398580011411	putative active site [active]
398580011412	putative active site [active]
398580011413	catalytic site [active]
398580011414	catalytic site [active]
398580011415	Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247
398580011416	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
398580011417	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
398580011418	Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231
398580011419	Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678
398580011420	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
398580011421	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
398580011422	D-pathway; other site
398580011423	Putative ubiquinol binding site [chemical binding]; other site
398580011424	Low-spin heme (heme b) binding site [chemical binding]; other site
398580011425	Putative water exit pathway; other site
398580011426	Binuclear center (heme o3/CuB) [ion binding]; other site
398580011427	K-pathway; other site
398580011428	Putative proton exit pathway; other site
398580011429	Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622
398580011430	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
398580011431	Cytochrome c; Region: Cytochrom_C; pfam00034
398580011432	Cytochrome c; Region: Cytochrom_C; cl11414
398580011433	Cytochrome c553 [Energy production and conversion]; Region: COG2863
398580011434	Cytochrome c; Region: Cytochrom_C; cl11414
398580011435	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
398580011436	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
398580011437	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
398580011438	Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618
398580011439	MgtC family; Region: MgtC; pfam02308
398580011440	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
398580011441	Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase) and related proteins; Region: AmyAc_OligoGlu; cd11330
398580011442	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
398580011443	active site
398580011444	catalytic site [active]
398580011445	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
398580011446	short chain dehydrogenase; Provisional; Region: PRK06701
398580011447	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
398580011448	NAD(P) binding site [chemical binding]; other site
398580011449	active site
398580011450	short chain dehydrogenase; Provisional; Region: PRK07109
398580011451	classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360
398580011452	putative NAD(P) binding site [chemical binding]; other site
398580011453	active site
398580011454	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
398580011455	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
398580011456	HlyD family secretion protein; Region: HlyD_3; pfam13437
398580011457	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
398580011458	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
398580011459	NAD(P) binding site [chemical binding]; other site
398580011460	active site
398580011461	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
398580011462	Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322
398580011463	Na binding site [ion binding]; other site
398580011464	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
398580011465	Mechanosensitive ion channel; Region: MS_channel; pfam00924
398580011466	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
398580011467	Na binding site [ion binding]; other site
398580011468	Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530
398580011469	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
398580011470	Domain of unknown function DUF20; Region: UPF0118; pfam01594
398580011471	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
398580011472	YrhK-like protein; Region: YrhK; pfam14145
398580011473	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
398580011474	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
398580011475	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
398580011476	protein binding site [polypeptide binding]; other site
398580011477	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
398580011478	protein binding site [polypeptide binding]; other site
398580011479	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
398580011480	dimerization interface [polypeptide binding]; other site
398580011481	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
398580011482	DPS ferroxidase diiron center [ion binding]; other site
398580011483	ion pore; other site
398580011484	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
398580011485	TrkA-N domain; Region: TrkA_N; pfam02254
398580011486	TrkA-C domain; Region: TrkA_C; pfam02080
398580011487	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
398580011488	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
398580011489	Proteolipid membrane potential modulator; Region: Pmp3; pfam01679
398580011490	Domain of unknown function (DUF4112); Region: DUF4112; pfam13430
398580011491	Protein required for attachment to host cells; Region: Host_attach; pfam10116
398580011492	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
398580011493	Transposase; Region: HTH_Tnp_1; pfam01527
398580011494	putative transposase OrfB; Reviewed; Region: PHA02517
398580011495	Integrase core domain; Region: rve; pfam00665
398580011496	Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226
398580011497	Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071
398580011498	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
398580011499	catalytic triad [active]
398580011500	Putative amidoligase enzyme; Region: Amidoligase_2; pfam12224
398580011501	Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1),  6-pyrovoyl...; Region: TFold; cl00263
398580011502	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105
398580011503	Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574
398580011504	Transcriptional regulators [Transcription]; Region: GntR; COG1802
398580011505	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
398580011506	DNA-binding site [nucleotide binding]; DNA binding site
398580011507	FCD domain; Region: FCD; pfam07729
398580011508	Glutaredoxin and related proteins [Posttranslational modification, protein turnover, chaperones]; Region: GrxC; COG0695
398580011509	Domain of unknown function (DUF305); Region: DUF305; cl17794
398580011510	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
398580011511	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
398580011512	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
398580011513	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
398580011514	Multicopper oxidase; Region: Cu-oxidase; pfam00394
398580011515	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
398580011516	Disulfide bond formation protein DsbB; Region: DsbB; pfam02600
398580011517	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
398580011518	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
398580011519	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302
398580011520	EF-hand domain pair; Region: EF_hand_5; pfam13499
398580011521	Ca2+ binding site [ion binding]; other site
398580011522	Domain of unknown function DUF302; Region: DUF302; pfam03625
398580011523	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
398580011524	copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511
398580011525	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
398580011526	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
398580011527	motif II; other site
398580011528	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
398580011529	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683
398580011530	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
398580011531	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
398580011532	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
398580011533	Protein of unknown function (DUF1672); Region: DUF1672; pfam07901
398580011534	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
398580011535	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
398580011536	haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710
398580011537	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
398580011538	dimerization interface [polypeptide binding]; other site
398580011539	putative Zn2+ binding site [ion binding]; other site
398580011540	putative DNA binding site [nucleotide binding]; other site
398580011541	Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529
398580011542	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
398580011543	apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302
398580011544	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
398580011545	putative active site [active]
398580011546	catalytic triad [active]
398580011547	putative dimer interface [polypeptide binding]; other site
398580011548	Signal peptidase (SPase) II; Region: Peptidase_A8; pfam01252
398580011549	lipoprotein signal peptidase; Provisional; Region: PRK14787
398580011550	ZIP Zinc transporter; Region: Zip; pfam02535
398580011551	Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428
398580011552	Protein of unknown function, DUF; Region: DUF411; cl01142
398580011553	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
398580011554	Peptidase family M23; Region: Peptidase_M23; pfam01551
398580011555	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
398580011556	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
398580011557	Cu(I) binding site [ion binding]; other site
398580011558	Protein of unknown function (DUF461); Region: DUF461; pfam04314
398580011559	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
398580011560	Thioredoxin; Region: Thioredoxin_4; pfam13462
398580011561	Disulfide bond formation protein DsbB; Region: DsbB; cl00649
398580011562	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
398580011563	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
398580011564	Cu(I) binding site [ion binding]; other site
398580011565	zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514
398580011566	Helix-Turn-Helix DNA binding domain of the CadR- and PbrR-like transcription regulators; Region: HTH_CadR-PbrR-like; cd04785
398580011567	DNA binding residues [nucleotide binding]
398580011568	dimer interface [polypeptide binding]; other site
398580011569	putative metal binding site [ion binding]; other site
398580011570	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
398580011571	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
398580011572	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
398580011573	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
398580011574	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
398580011575	Protein of unknown function (DUF3478); Region: DUF3478; pfam11964
398580011576	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
398580011577	dimerization interface [polypeptide binding]; other site
398580011578	putative DNA binding site [nucleotide binding]; other site
398580011579	putative Zn2+ binding site [ion binding]; other site
398580011580	Heavy-metal-associated domain; Region: HMA; pfam00403
398580011581	metal-binding site [ion binding]
398580011582	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
398580011583	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
398580011584	non-specific DNA binding site [nucleotide binding]; other site
398580011585	salt bridge; other site
398580011586	sequence-specific DNA binding site [nucleotide binding]; other site
398580011587	Cep120 protein; Region: DUF3668; pfam12416
398580011588	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
398580011589	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
398580011590	N-acetyl-D-glucosamine binding site [chemical binding]; other site
398580011591	catalytic residue [active]
398580011592	TrbC/VIRB2 family; Region: TrbC; pfam04956
398580011593	Type IV secretory pathway, VirB3-like protein; Region: VirB3; cl01501
398580011594	type IV secretion/conjugal transfer ATPase, VirB4 family; Region: VirB4_CagE; TIGR00929
398580011595	CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135
398580011596	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
398580011597	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
398580011598	N-acetyl-D-glucosamine binding site [chemical binding]; other site
398580011599	catalytic residue [active]
398580011600	P-type DNA transfer protein VirB5; Region: VirB5; TIGR02791
398580011601	Type IV secretion system proteins; Region: T4SS; pfam07996
398580011602	VirB8 protein; Region: VirB8; pfam04335
398580011603	VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cl11423
398580011604	VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911
398580011605	VirB7 interaction site; other site
398580011606	Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743
398580011607	P-type DNA transfer ATPase VirB11; Region: VirB11; TIGR02788
398580011608	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
398580011609	Walker A motif; other site
398580011610	hexamer interface [polypeptide binding]; other site
398580011611	ATP binding site [chemical binding]; other site
398580011612	Walker B motif; other site
398580011613	TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; pfam04610
398580011614	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
398580011615	AAA domain; Region: AAA_23; pfam13476
398580011616	Walker A/P-loop; other site
398580011617	ATP binding site [chemical binding]; other site
398580011618	Type IV secretory system Conjugative DNA transfer; Region: T4SS-DNA_transf; pfam02534
398580011619	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
398580011620	Walker A motif; other site
398580011621	ATP binding site [chemical binding]; other site
398580011622	Walker B motif; other site
398580011623	type IV secretion system T-DNA border endonuclease VirD2; Provisional; Region: PRK13863
398580011624	Homeodomain-like domain; Region: HTH_23; cl17451
398580011625	Protein of unknown function (DUF3620); Region: DUF3620; cl02233
398580011626	Protein of unknown function (DUF2493); Region: DUF2493; pfam10686
398580011627	Uncharacterized ACR, COG2135; Region: DUF159; cl03646
398580011628	Uncharacterized conserved protein [Function unknown]; Region: COG4544
398580011629	DNA Polymerase Y-family; Region: PolY_like; cd03468
398580011630	active site
398580011631	Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389
398580011632	DNA binding site [nucleotide binding]
398580011633	error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672
398580011634	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434
398580011635	putative active site [active]
398580011636	putative PHP Thumb interface [polypeptide binding]; other site
398580011637	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
398580011638	generic binding surface II; other site
398580011639	generic binding surface I; other site
398580011640	Protein of unknown function (DUF736); Region: DUF736; pfam05284
398580011641	Protein of unknown function (DUF736); Region: DUF736; pfam05284
398580011642	Helicase_C-like; Region: Helicase_C_4; pfam13871
398580011643	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
398580011644	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235
398580011645	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
398580011646	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
398580011647	active site
398580011648	DNA binding site [nucleotide binding]
398580011649	Int/Topo IB signature motif; other site
398580011650	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
398580011651	active site
398580011652	DNA binding site [nucleotide binding]
398580011653	Int/Topo IB signature motif; other site
398580011654	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
398580011655	INT_SG5, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 5, N- and C-terminal domains. The CD contains mainly predicted bacterial integrase/recombinases; Region: INT_SG5; cd01190
398580011656	Int/Topo IB signature motif; other site
398580011657	AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287
398580011658	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
398580011659	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
398580011660	ATP binding site [chemical binding]; other site
398580011661	putative Mg++ binding site [ion binding]; other site
398580011662	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
398580011663	nucleotide binding region [chemical binding]; other site
398580011664	ATP-binding site [chemical binding]; other site
398580011665	Methyltransferase domain; Region: Methyltransf_26; pfam13659
398580011666	P-loop containing NTP hydrolase pore-1; Region: AAA_34; pfam13872
398580011667	Transcriptional regulator [Transcription]; Region: LysR; COG0583
398580011668	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
398580011669	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
398580011670	dimerization interface [polypeptide binding]; other site
398580011671	Toxin with endonuclease activity YhaV; Region: Toxin_YhaV; pfam11663
398580011672	putative regulator PrlF; Provisional; Region: PRK09974
398580011673	Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002
398580011674	ParB-like nuclease domain; Region: ParB; smart00470
398580011675	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
398580011676	Protein of unknown function (DUF3768); Region: DUF3768; pfam12599
398580011677	Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227
398580011678	Domain of unknown function (DUF1738); Region: DUF1738; pfam08401
398580011679	Fic family protein [Function unknown]; Region: COG3177
398580011680	Fic/DOC family; Region: Fic; pfam02661
398580011681	replication initiation protein RepC; Provisional; Region: PRK13824
398580011682	Replication protein C N-terminal domain; Region: RP-C; pfam03428
398580011683	Replication protein C C-terminal region; Region: RP-C_C; pfam11800
398580011684	plasmid partitioning protein RepB; Region: partition_RepB; TIGR03454
398580011685	ParB-like nuclease domain; Region: ParB; smart00470
398580011686	plasmid partitioning protein RepA; Region: partition_RepA; TIGR03453
398580011687	MerR family regulatory protein; Region: MerR; pfam00376
398580011688	DNA binding residues [nucleotide binding]
398580011689	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
398580011690	P-loop; other site
398580011691	Magnesium ion binding site [ion binding]; other site
398580011692	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
398580011693	Magnesium ion binding site [ion binding]; other site
398580011694	Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877
398580011695	PIN domains of VapC and Smg6 ribonucleases, ribosome assembly factor NOB1, Archaeoglobus fulgidus AF0591 protein and homologs; Region: PIN_VapC-Smg6-like; cd09855
398580011696	putative active site [active]
398580011697	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
398580011698	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
398580011699	catalytic residues [active]
398580011700	catalytic nucleophile [active]
398580011701	Presynaptic Site I dimer interface [polypeptide binding]; other site
398580011702	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
398580011703	Synaptic Flat tetramer interface [polypeptide binding]; other site
398580011704	Synaptic Site I dimer interface [polypeptide binding]; other site
398580011705	DNA binding site [nucleotide binding]
398580011706	Cre recombinase, C-terminal catalytic domain. Cre-like recombinases belong to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The bacteriophage P1 Cre...; Region: INT_Cre; cd00799
398580011707	DNA binding site [nucleotide binding]
398580011708	dimer interface [polypeptide binding]; other site
398580011709	Int/Topo IB signature motif; other site
398580011710	active site
398580011711	Protein of unknown function (DUF1403); Region: DUF1403; pfam07183
398580011712	Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079
398580011713	WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996
398580011714	Fic family protein [Function unknown]; Region: COG3177
398580011715	Domain of unknown function (DUF4172); Region: DUF4172; pfam13776
398580011716	Fic/DOC family; Region: Fic; pfam02661
398580011717	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
398580011718	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
398580011719	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
398580011720	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
398580011721	Transposase; Region: DEDD_Tnp_IS110; pfam01548
398580011722	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
398580011723	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
398580011724	Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal; Region: UCR_Fe-S_N; pfam10399
398580011725	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
398580011726	Homeodomain-like domain; Region: HTH_23; cl17451
398580011727	DDE superfamily endonuclease; Region: DDE_3; pfam13358
398580011728	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
398580011729	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
398580011730	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
398580011731	ligand binding site [chemical binding]; other site
398580011732	Protein of unknown function, DUF; Region: DUF411; cl01142
398580011733	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
398580011734	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
398580011735	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
398580011736	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
398580011737	Uncharacterized conserved protein [Function unknown]; Region: COG0398
398580011738	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
398580011739	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: PspE; COG0607
398580011740	active site residue [active]
398580011741	osmolarity response regulator; Provisional; Region: ompR; PRK09468
398580011742	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
398580011743	active site
398580011744	phosphorylation site [posttranslational modification]
398580011745	intermolecular recognition site; other site
398580011746	dimerization interface [polypeptide binding]; other site
398580011747	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
398580011748	DNA binding site [nucleotide binding]
398580011749	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
398580011750	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
398580011751	dimerization interface [polypeptide binding]; other site
398580011752	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
398580011753	dimer interface [polypeptide binding]; other site
398580011754	phosphorylation site [posttranslational modification]
398580011755	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
398580011756	ATP binding site [chemical binding]; other site
398580011757	Mg2+ binding site [ion binding]; other site
398580011758	G-X-G motif; other site
398580011759	Predicted membrane protein [Function unknown]; Region: COG3462
398580011760	Short C-terminal domain; Region: SHOCT; pfam09851
398580011761	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138
398580011762	periplasmic protein thiol:disulfide oxidoreductases, DsbE subfamily; Region: dsbE; TIGR00385
398580011763	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
398580011764	Cytochrome C biogenesis protein; Region: CcmH; pfam03918
398580011765	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235
398580011766	cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142
398580011767	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
398580011768	Disulphide bond corrector protein DsbC; Region: DsbC; cl15830
398580011769	Thiol:disulfide interchange protein [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4232
398580011770	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
398580011771	DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953
398580011772	DsbD alpha interface [polypeptide binding]; other site
398580011773	catalytic residues [active]
398580011774	Predicted membrane protein [Function unknown]; Region: COG1288; cl17886
398580011775	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
398580011776	Cytochrome c; Region: Cytochrom_C; pfam00034
398580011777	Cytochrome C' Region: Cytochrom_C_2; pfam01322
398580011778	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
398580011779	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
398580011780	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
398580011781	Multicopper oxidase; Region: Cu-oxidase; pfam00394
398580011782	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
398580011783	Cytochrome c; Region: Cytochrom_C; pfam00034
398580011784	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
398580011785	DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023
398580011786	catalytic residues [active]
398580011787	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
398580011788	metal-binding site [ion binding]
398580011789	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
398580011790	metal-binding site [ion binding]
398580011791	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
398580011792	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
398580011793	metal-binding site [ion binding]
398580011794	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
398580011795	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
398580011796	motif II; other site
398580011797	Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044
398580011798	Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108
398580011799	DNA binding residues [nucleotide binding]
398580011800	dimer interface [polypeptide binding]; other site
398580011801	copper binding site [ion binding]; other site
398580011802	Autoinducer binding domain; Region: Autoind_bind; pfam03472
398580011803	Right handed beta helix region; Region: Beta_helix; pfam13229
398580011804	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cl17457
398580011805	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
398580011806	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
398580011807	Transposase; Region: HTH_Tnp_1; pfam01527
398580011808	Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsE; COG3524
398580011809	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
398580011810	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
398580011811	Walker A/P-loop; other site
398580011812	ATP binding site [chemical binding]; other site
398580011813	Q-loop/lid; other site
398580011814	ABC transporter signature motif; other site
398580011815	Walker B; other site
398580011816	D-loop; other site
398580011817	H-loop/switch region; other site
398580011818	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
398580011819	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
398580011820	thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284
398580011821	ThiC-associated domain; Region: ThiC-associated; pfam13667
398580011822	Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422
398580011823	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
398580011824	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
398580011825	catalytic residues [active]
398580011826	catalytic nucleophile [active]
398580011827	Presynaptic Site I dimer interface [polypeptide binding]; other site
398580011828	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
398580011829	Synaptic Flat tetramer interface [polypeptide binding]; other site
398580011830	Synaptic Site I dimer interface [polypeptide binding]; other site
398580011831	DNA binding site [nucleotide binding]
398580011832	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
398580011833	DNA-binding interface [nucleotide binding]; DNA binding site
398580011834	Winged helix-turn helix; Region: HTH_29; pfam13551
398580011835	Helix-turn-helix domain; Region: HTH_28; pfam13518
398580011836	Homeodomain-like domain; Region: HTH_32; pfam13565
398580011837	Integrase core domain; Region: rve; pfam00665
398580011838	Integrase core domain; Region: rve_3; cl15866
398580011839	Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299
398580011840	AAA domain; Region: AAA_22; pfam13401
398580011841	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
398580011842	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
398580011843	catalytic residues [active]
398580011844	catalytic nucleophile [active]
398580011845	Presynaptic Site I dimer interface [polypeptide binding]; other site
398580011846	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
398580011847	Synaptic Flat tetramer interface [polypeptide binding]; other site
398580011848	Synaptic Site I dimer interface [polypeptide binding]; other site
398580011849	DNA binding site [nucleotide binding]
398580011850	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
398580011851	DNA-binding interface [nucleotide binding]; DNA binding site
398580011852	WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996
398580011853	Uncharacterized protein family (UPF0156); Region: RHH_2; cl17383
398580011854	Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668
398580011855	HTH-like domain; Region: HTH_21; pfam13276
398580011856	Integrase core domain; Region: rve; pfam00665
398580011857	Integrase core domain; Region: rve_3; pfam13683
398580011858	Transposase; Region: HTH_Tnp_1; pfam01527
398580011859	Transposase; Region: DEDD_Tnp_IS110; pfam01548
398580011860	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
398580011861	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
398580011862	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
398580011863	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
398580011864	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
398580011865	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
398580011866	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
398580011867	replication initiation protein RepC; Provisional; Region: PRK13824
398580011868	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
398580011869	putative DNA binding site [nucleotide binding]; other site
398580011870	putative Zn2+ binding site [ion binding]; other site
398580011871	Replication protein C C-terminal region; Region: RP-C_C; pfam11800
398580011872	ParB-like nuclease domain; Region: ParBc; pfam02195
398580011873	RepB plasmid partitioning protein; Region: RepB; pfam07506
398580011874	plasmid partitioning protein RepA; Region: partition_RepA; TIGR03453
398580011875	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
398580011876	DNA binding residues [nucleotide binding]
398580011877	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
398580011878	P-loop; other site
398580011879	Magnesium ion binding site [ion binding]; other site
398580011880	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
398580011881	Magnesium ion binding site [ion binding]; other site
398580011882	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
398580011883	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
398580011884	catalytic residues [active]
398580011885	catalytic nucleophile [active]
398580011886	Presynaptic Site I dimer interface [polypeptide binding]; other site
398580011887	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
398580011888	Synaptic Flat tetramer interface [polypeptide binding]; other site
398580011889	Synaptic Site I dimer interface [polypeptide binding]; other site
398580011890	DNA binding site [nucleotide binding]
398580011891	HTH DNA binding domain; Region: HTH_13; pfam11972
398580011892	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
398580011893	active site
398580011894	Int/Topo IB signature motif; other site
398580011895	DNA binding site [nucleotide binding]
398580011896	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
398580011897	Fic/DOC family; Region: Fic; cl00960
398580011898	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908
398580011899	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
398580011900	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
398580011901	NAD binding site [chemical binding]; other site
398580011902	substrate binding site [chemical binding]; other site
398580011903	homodimer interface [polypeptide binding]; other site
398580011904	active site
398580011905	Sulfotransferase family; Region: Sulfotransfer_2; pfam03567
398580011906	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
398580011907	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
398580011908	NADP binding site [chemical binding]; other site
398580011909	active site
398580011910	putative substrate binding site [chemical binding]; other site
398580011911	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
398580011912	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
398580011913	substrate binding site; other site
398580011914	tetramer interface; other site
398580011915	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
398580011916	NAD(P) binding site [chemical binding]; other site
398580011917	active site
398580011918	Bacterial sugar transferase; Region: Bac_transf; pfam02397
398580011919	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
398580011920	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
398580011921	active site
398580011922	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
398580011923	Sulfotransferase family; Region: Sulfotransfer_2; pfam03567
398580011924	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
398580011925	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
398580011926	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
398580011927	Right handed beta helix region; Region: Beta_helix; pfam13229
398580011928	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cl17457
398580011929	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
398580011930	Oligosaccharide biosynthesis protein Alg14 like; Region: Alg14; pfam08660
398580011931	Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl17369
398580011932	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term; Region: FrhB_FdhB_N; pfam04422
398580011933	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432
398580011934	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230
398580011935	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230
398580011936	O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425
398580011937	Alpha 1,6-fucosyltransferase similar to Bradyrhizobium NodZ; Region: NodZ_like; cd11548
398580011938	GDP-Fucose binding site [chemical binding]; other site
398580011939	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
398580011940	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
398580011941	NADP-binding site; other site
398580011942	homotetramer interface [polypeptide binding]; other site
398580011943	substrate binding site [chemical binding]; other site
398580011944	homodimer interface [polypeptide binding]; other site
398580011945	active site
398580011946	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
398580011947	Methyltransferase domain; Region: Methyltransf_22; pfam13383
398580011948	GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239
398580011949	GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725
398580011950	NADP binding site [chemical binding]; other site
398580011951	active site
398580011952	putative substrate binding site [chemical binding]; other site
398580011953	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
398580011954	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
398580011955	active site
398580011956	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
398580011957	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
398580011958	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
398580011959	trimer interface [polypeptide binding]; other site
398580011960	active site
398580011961	substrate binding site [chemical binding]; other site
398580011962	CoA binding site [chemical binding]; other site
398580011963	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
398580011964	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
398580011965	Probable Catalytic site; other site
398580011966	metal-binding site
398580011967	mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479
398580011968	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
398580011969	Substrate binding site; other site
398580011970	Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050
398580011971	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
398580011972	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
398580011973	active site
398580011974	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
398580011975	ABC-2 type transporter; Region: ABC2_membrane; cl17235
398580011976	Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349
398580011977	trimer interface [polypeptide binding]; other site
398580011978	active site
398580011979	substrate binding site [chemical binding]; other site
398580011980	CoA binding site [chemical binding]; other site
398580011981	Sulfotransferase family; Region: Sulfotransfer_2; pfam03567
398580011982	Autoinducer synthetase; Region: Autoind_synth; cl17404
398580011983	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
398580011984	Sulfur oxidation protein SoxY; Region: SoxY; pfam13501
398580011985	Sulphur oxidation protein SoxZ; Region: SoxZ; pfam08770
398580011986	Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284
398580011987	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
398580011988	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
398580011989	SnoaL-like domain; Region: SnoaL_2; pfam12680
398580011990	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
398580011991	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
398580011992	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
398580011993	acetoin reductases; Region: 23BDH; TIGR02415
398580011994	NAD(P) binding site [chemical binding]; other site
398580011995	active site
398580011996	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
398580011997	(2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233
398580011998	putative NAD(P) binding site [chemical binding]; other site
398580011999	catalytic Zn binding site [ion binding]; other site
398580012000	protochlorophyllide oxidoreductase; Validated; Region: PRK07453
398580012001	light-dependent protochlorophyllide reductase; Region: LPOR; TIGR01289
398580012002	NAD(P) binding site [chemical binding]; other site
398580012003	active site
398580012004	MltA-interacting protein MipA; Region: MipA; cl01504
398580012005	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
398580012006	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
398580012007	Binding-protein-dependent transport system inner membrane component; Region: BPD_transp_1; pfam00528
398580012008	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
398580012009	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
398580012010	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
398580012011	Walker A/P-loop; other site
398580012012	ATP binding site [chemical binding]; other site
398580012013	Q-loop/lid; other site
398580012014	ABC transporter signature motif; other site
398580012015	Walker B; other site
398580012016	D-loop; other site
398580012017	H-loop/switch region; other site
398580012018	NMT1/THI5 like; Region: NMT1; pfam09084
398580012019	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
398580012020	glucosyltransferase MdoH; Provisional; Region: PRK05454
398580012021	active site
398580012022	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
398580012023	glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274
398580012024	glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273
398580012025	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
398580012026	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
398580012027	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
398580012028	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
398580012029	SnoaL-like domain; Region: SnoaL_4; pfam13577
398580012030	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
398580012031	Ferredoxin reductase-like proteins catalyze electron transfer between an NAD(P)-binding domain of the alpha/beta class and a discrete (usually N-terminal) domain which varies in orientation with respect to the NAD(P) binding domain. The N-terminal region...; Region: FNR_like_1; cd06196
398580012032	FAD binding pocket [chemical binding]; other site
398580012033	FAD binding motif [chemical binding]; other site
398580012034	phosphate binding motif [ion binding]; other site
398580012035	beta-alpha-beta structure motif; other site
398580012036	NAD binding pocket [chemical binding]; other site
398580012037	Acetamidase/Formamidase family; Region: FmdA_AmdA; pfam03069
398580012038	Dodecin; Region: Dodecin; cl01328
398580012039	Protein of unknown function (DUF3618); Region: DUF3618; pfam12277
398580012040	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
398580012041	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
398580012042	Mechanosensitive ion channel; Region: MS_channel; pfam00924
398580012043	CsbD-like; Region: CsbD; pfam05532
398580012044	Transcriptional regulators [Transcription]; Region: FadR; COG2186
398580012045	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
398580012046	DNA-binding site [nucleotide binding]; DNA binding site
398580012047	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
398580012048	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
398580012049	Walker A/P-loop; other site
398580012050	ATP binding site [chemical binding]; other site
398580012051	Q-loop/lid; other site
398580012052	ABC transporter signature motif; other site
398580012053	Walker B; other site
398580012054	D-loop; other site
398580012055	H-loop/switch region; other site
398580012056	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
398580012057	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
398580012058	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
398580012059	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
398580012060	dimer interface [polypeptide binding]; other site
398580012061	conserved gate region; other site
398580012062	putative PBP binding loops; other site
398580012063	ABC-ATPase subunit interface; other site
398580012064	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
398580012065	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
398580012066	Uncharacterized conserved protein [Function unknown]; Region: COG3391
398580012067	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
398580012068	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
398580012069	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290
398580012070	DctM-like transporters; Region: DctM; pfam06808
398580012071	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
398580012072	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
398580012073	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
398580012074	Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772
398580012075	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
398580012076	Transcriptional regulator [Transcription]; Region: LysR; COG0583
398580012077	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
398580012078	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_2; cd08427
398580012079	putative dimerization interface [polypeptide binding]; other site
398580012080	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
398580012081	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
398580012082	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
398580012083	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450
398580012084	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
398580012085	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
398580012086	catalytic loop [active]
398580012087	iron binding site [ion binding]; other site
398580012088	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
398580012089	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
398580012090	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
398580012091	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
398580012092	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
398580012093	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
398580012094	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290
398580012095	DctM-like transporters; Region: DctM; pfam06808
398580012096	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
398580012097	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
398580012098	D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558
398580012099	homodimer interface [polypeptide binding]; other site
398580012100	substrate-cofactor binding pocket; other site
398580012101	pyridoxal 5'-phosphate binding site [chemical binding]; other site
398580012102	catalytic residue [active]
398580012103	Alpha/beta hydrolase of unknown function (DUF900); Region: DUF900; pfam05990
398580012104	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
398580012105	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
398580012106	active site
398580012107	catalytic site [active]
398580012108	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
398580012109	oligomeric interface; other site
398580012110	putative active site [active]
398580012111	homodimer interface [polypeptide binding]; other site
398580012112	Plasmid stability protein [General function prediction only]; Region: StbC; COG4691
398580012113	ParB-like nuclease domain; Region: ParBc; pfam02195
398580012114	plasmid partitioning protein RepA; Region: partition_RepA; TIGR03453
398580012115	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
398580012116	P-loop; other site
398580012117	Magnesium ion binding site [ion binding]; other site
398580012118	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
398580012119	Magnesium ion binding site [ion binding]; other site
398580012120	Initiator Replication protein; Region: Rep_3; pfam01051
398580012121	Protein of unknown function (DUF3047); Region: DUF3047; pfam11249
398580012122	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
398580012123	ABC1 family; Region: ABC1; pfam03109
398580012124	Transcriptional regulators [Transcription]; Region: PurR; COG1609
398580012125	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
398580012126	DNA binding site [nucleotide binding]
398580012127	domain linker motif; other site
398580012128	Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575
398580012129	putative dimerization interface [polypeptide binding]; other site
398580012130	putative ligand binding site [chemical binding]; other site
398580012131	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
398580012132	Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331
398580012133	Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772
398580012134	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
398580012135	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
398580012136	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
398580012137	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
398580012138	dimerization interface [polypeptide binding]; other site
398580012139	DPS ferroxidase diiron center [ion binding]; other site
398580012140	ion pore; other site
398580012141	Protein of unknown function (DUF1289); Region: DUF1289; cl01304
398580012142	Hemin uptake protein hemP; Region: hemP; pfam10636
398580012143	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
398580012144	active site residue [active]